ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	8.99411179
2	nucleobase catabolic process (GO:0046113)	7.27482027
3	epithelial cilium movement (GO:0003351)	4.99335605
4	cilium movement (GO:0003341)	4.94265050
5	presynaptic membrane assembly (GO:0097105)	4.92107155
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.90371049
7	cilium or flagellum-dependent cell motility (GO:0001539)	4.61485749
8	presynaptic membrane organization (GO:0097090)	4.25059310
9	regulation of cilium movement (GO:0003352)	4.06806898
10	axoneme assembly (GO:0035082)	4.06575372
11	axonemal dynein complex assembly (GO:0070286)	4.00422636
12	intraciliary transport (GO:0042073)	3.85195772
13	postsynaptic membrane organization (GO:0001941)	3.80800765
14	behavioral response to nicotine (GO:0035095)	3.80721847
15	positive regulation of mitochondrial fission (GO:0090141)	3.76105846
16	regulation of feeding behavior (GO:0060259)	3.67312917
17	neuron cell-cell adhesion (GO:0007158)	3.65720861
18	neural tube formation (GO:0001841)	3.55360966
19	protein polyglutamylation (GO:0018095)	3.53137857
20	dendritic spine morphogenesis (GO:0060997)	3.51045992
21	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.46153861
22	vocalization behavior (GO:0071625)	3.44721202
23	nonmotile primary cilium assembly (GO:0035058)	3.43425991
24	cilium organization (GO:0044782)	3.42541052
25	olfactory bulb development (GO:0021772)	3.40107701
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.39596450
27	cilium assembly (GO:0042384)	3.35924858
28	cilium morphogenesis (GO:0060271)	3.28702408
29	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.21248430
30	retinal ganglion cell axon guidance (GO:0031290)	3.21033961
31	seminiferous tubule development (GO:0072520)	3.19955909
32	response to pheromone (GO:0019236)	3.12251199
33	synapse assembly (GO:0007416)	3.08830893
34	central nervous system projection neuron axonogenesis (GO:0021952)	3.02006661
35	transmission of nerve impulse (GO:0019226)	3.01288428
36	glycosphingolipid biosynthetic process (GO:0006688)	2.97314532
37	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.96669243
38	brain morphogenesis (GO:0048854)	2.96215887
39	regulation of action potential (GO:0098900)	2.92392523
40	protein localization to synapse (GO:0035418)	2.92285735
41	piRNA metabolic process (GO:0034587)	2.89963658
42	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.89669462
43	protein K11-linked deubiquitination (GO:0035871)	2.89116035
44	left/right axis specification (GO:0070986)	2.86556131
45	protein localization to cilium (GO:0061512)	2.85342839
46	central nervous system neuron axonogenesis (GO:0021955)	2.83899766
47	photoreceptor cell maintenance (GO:0045494)	2.82612441
48	regulation of microtubule-based movement (GO:0060632)	2.82193275
49	cellular component assembly involved in morphogenesis (GO:0010927)	2.81899925
50	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.80872848
51	neuron recognition (GO:0008038)	2.76835093
52	axonal fasciculation (GO:0007413)	2.75495544
53	limb development (GO:0060173)	2.73700553
54	appendage development (GO:0048736)	2.73700553
55	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.71354430
56	regulation of glucokinase activity (GO:0033131)	2.68481553
57	regulation of hexokinase activity (GO:1903299)	2.68481553
58	positive regulation of amino acid transport (GO:0051957)	2.66679128
59	regulation of synapse structural plasticity (GO:0051823)	2.56517899
60	microtubule bundle formation (GO:0001578)	2.48601699
61	establishment of nucleus localization (GO:0040023)	2.48016892
62	behavioral response to ethanol (GO:0048149)	2.47046346
63	somite rostral/caudal axis specification (GO:0032525)	2.47022597
64	spinal cord development (GO:0021510)	2.45719655
65	establishment of protein localization to Golgi (GO:0072600)	2.45685476
66	motile cilium assembly (GO:0044458)	2.45590235
67	regulation of mitochondrial fission (GO:0090140)	2.44778586
68	sympathetic nervous system development (GO:0048485)	2.44344427
69	acrosome assembly (GO:0001675)	2.43744189
70	ganglion development (GO:0061548)	2.43740462
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.43582748
72	cerebral cortex radially oriented cell migration (GO:0021799)	2.41919243
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.41663403
74	negative regulation of mast cell activation (GO:0033004)	2.40558120
75	positive regulation of meiosis (GO:0045836)	2.40138107
76	DNA methylation involved in gamete generation (GO:0043046)	2.40043594
77	establishment of mitochondrion localization (GO:0051654)	2.39912191
78	DNA integration (GO:0015074)	2.39067306
79	retinal cone cell development (GO:0046549)	2.38751323
80	positive regulation of gastrulation (GO:2000543)	2.36420741
81	limb bud formation (GO:0060174)	2.35992609
82	regulation of respiratory system process (GO:0044065)	2.35716617
83	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.35688202
84	regulation of telomere maintenance (GO:0032204)	2.34686158
85	reflex (GO:0060004)	2.33885507
86	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.33475305
87	gamma-aminobutyric acid transport (GO:0015812)	2.32881929
88	regulation of neurotransmitter uptake (GO:0051580)	2.32574040
89	rRNA catabolic process (GO:0016075)	2.32011980
90	sialylation (GO:0097503)	2.31410611
91	regulation of dendritic spine morphogenesis (GO:0061001)	2.31190932
92	positive regulation of action potential (GO:0045760)	2.30708450
93	determination of left/right symmetry (GO:0007368)	2.29687429
94	regulation of development, heterochronic (GO:0040034)	2.29331710
95	smoothened signaling pathway (GO:0007224)	2.29110708
96	neuron fate determination (GO:0048664)	2.27792547
97	regulation of male gonad development (GO:2000018)	2.27580770
98	atrial cardiac muscle cell action potential (GO:0086014)	2.27401871
99	protein targeting to Golgi (GO:0000042)	2.26554090
100	kidney morphogenesis (GO:0060993)	2.26466219

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95044294
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.73339444
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.37552049
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.35244055
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.33642150
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.07490790
7	VDR_22108803_ChIP-Seq_LS180_Human	2.78462249
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69585343
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.59858197
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.49623824
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.38275251
12	FUS_26573619_Chip-Seq_HEK293_Human	2.36717257
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21512795
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21328435
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20420047
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.13102210
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.10205855
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09858624
19	P300_19829295_ChIP-Seq_ESCs_Human	2.06630183
20	EWS_26573619_Chip-Seq_HEK293_Human	2.05844223
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95520642
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.91910683
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.88442749
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.85502434
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82168588
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81714759
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80271004
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78793329
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.76152955
30	STAT3_23295773_ChIP-Seq_U87_Human	1.65130114
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.65089022
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64397197
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.63461263
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62582140
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62582140
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59377134
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58876751
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58782759
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50125506
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49758913
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.47396651
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.45158573
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44917057
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.44917057
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.44563738
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43688766
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43421240
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.42220251
49	AR_25329375_ChIP-Seq_VCAP_Human	1.41601637
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41372039
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40629786
52	TCF4_23295773_ChIP-Seq_U87_Human	1.39325223
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33154719
54	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29368479
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28710785
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28706547
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.27814883
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27398457
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.26142489
60	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.23389639
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22956342
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22548431
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22165456
64	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21893151
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.21158102
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17904191
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17475746
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16167380
69	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14885620
70	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13707770
71	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12373379
72	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12175531
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11047883
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09979805
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09622801
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09259063
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07873678
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07100007
79	TP53_16413492_ChIP-PET_HCT116_Human	1.05422049
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.04356979
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04076787
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03547045
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03467868
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02087107
85	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00079962
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00079962
87	KDM2B_26808549_Chip-Seq_REH_Human	0.97808109
88	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96442482
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96391328
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.95788226
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95256726
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94852501
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94424349
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94322802
95	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.93782325
96	DROSHA_22980978_ChIP-Seq_HELA_Human	0.93268994
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91674286
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.91529654
99	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.91455501
100	JUN_21703547_ChIP-Seq_K562_Human	0.91367089

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.23177863
2	MP0003787_abnormal_imprinting	2.87469234
3	MP0001984_abnormal_olfaction	2.71463332
4	MP0001529_abnormal_vocalization	2.63342979
5	MP0006276_abnormal_autonomic_nervous	2.51722531
6	MP0008877_abnormal_DNA_methylation	2.44565140
7	MP0000778_abnormal_nervous_system	2.42483815
8	MP0002653_abnormal_ependyma_morphology	2.39118065
9	MP0006072_abnormal_retinal_apoptosis	2.38618902
10	MP0003122_maternal_imprinting	2.31582113
11	MP0004133_heterotaxia	2.28850280
12	MP0002638_abnormal_pupillary_reflex	2.25787246
13	MP0003121_genomic_imprinting	2.15401043
14	MP0006292_abnormal_olfactory_placode	2.15342809
15	MP0008789_abnormal_olfactory_epithelium	2.13073248
16	MP0005084_abnormal_gallbladder_morpholo	2.02669063
17	MP0000516_abnormal_urinary_system	2.02543350
18	MP0005367_renal/urinary_system_phenotyp	2.02543350
19	MP0005394_taste/olfaction_phenotype	1.99066339
20	MP0005499_abnormal_olfactory_system	1.99066339
21	MP0004270_analgesia	1.91909054
22	MP0001486_abnormal_startle_reflex	1.87966650
23	MP0004859_abnormal_synaptic_plasticity	1.87413181
24	MP0002102_abnormal_ear_morphology	1.83437217
25	MP0002751_abnormal_autonomic_nervous	1.81211691
26	MP0002735_abnormal_chemical_nociception	1.81143113
27	MP0005551_abnormal_eye_electrophysiolog	1.75478261
28	MP0005253_abnormal_eye_physiology	1.68034963
29	MP0002837_dystrophic_cardiac_calcinosis	1.66354648
30	MP0001968_abnormal_touch/_nociception	1.63645737
31	MP0003890_abnormal_embryonic-extraembry	1.60656693
32	MP0009780_abnormal_chondrocyte_physiolo	1.58967805
33	MP0008961_abnormal_basal_metabolism	1.58366306
34	MP0002572_abnormal_emotion/affect_behav	1.55886503
35	MP0009745_abnormal_behavioral_response	1.55127303
36	MP0003635_abnormal_synaptic_transmissio	1.54393620
37	MP0005645_abnormal_hypothalamus_physiol	1.50001382
38	MP0004043_abnormal_pH_regulation	1.49538621
39	MP0004142_abnormal_muscle_tone	1.47220746
40	MP0002736_abnormal_nociception_after	1.45738814
41	MP0002063_abnormal_learning/memory/cond	1.44322540
42	MP0009046_muscle_twitch	1.41664165
43	MP0000631_abnormal_neuroendocrine_gland	1.41488132
44	MP0002557_abnormal_social/conspecific_i	1.40910674
45	MP0002272_abnormal_nervous_system	1.38034191
46	MP0005646_abnormal_pituitary_gland	1.35796979
47	MP0002163_abnormal_gland_morphology	1.34119807
48	MP0002734_abnormal_mechanical_nocicepti	1.32457732
49	MP0000955_abnormal_spinal_cord	1.32241780
50	MP0000427_abnormal_hair_cycle	1.30709471
51	MP0008995_early_reproductive_senescence	1.30675473
52	MP0001485_abnormal_pinna_reflex	1.30318102
53	MP0003011_delayed_dark_adaptation	1.26200771
54	MP0002234_abnormal_pharynx_morphology	1.25928694
55	MP0004885_abnormal_endolymph	1.24159401
56	MP0002822_catalepsy	1.22423440
57	MP0005386_behavior/neurological_phenoty	1.21985789
58	MP0004924_abnormal_behavior	1.21985789
59	MP0005379_endocrine/exocrine_gland_phen	1.20925987
60	MP0002928_abnormal_bile_duct	1.20754417
61	MP0002184_abnormal_innervation	1.18764624
62	MP0002067_abnormal_sensory_capabilities	1.18310685
63	MP0005423_abnormal_somatic_nervous	1.15929158
64	MP0002064_seizures	1.15792097
65	MP0002752_abnormal_somatic_nervous	1.12890348
66	MP0002882_abnormal_neuron_morphology	1.11368049
67	MP0001970_abnormal_pain_threshold	1.08799771
68	MP0000049_abnormal_middle_ear	1.08655665
69	MP0003195_calcinosis	1.06818289
70	MP0002152_abnormal_brain_morphology	1.03728927
71	MP0001293_anophthalmia	1.03425930
72	MP0002876_abnormal_thyroid_physiology	1.02666691
73	MP0005195_abnormal_posterior_eye	0.99893563
74	MP0008872_abnormal_physiological_respon	0.99203799
75	MP0002909_abnormal_adrenal_gland	0.98311494
76	MP0003718_maternal_effect	0.98044313
77	MP0001502_abnormal_circadian_rhythm	0.97436389
78	MP0000026_abnormal_inner_ear	0.96130299
79	MP0001177_atelectasis	0.94347717
80	MP0002233_abnormal_nose_morphology	0.94341285
81	MP0004811_abnormal_neuron_physiology	0.94101214
82	MP0003136_yellow_coat_color	0.91863481
83	MP0000647_abnormal_sebaceous_gland	0.91813380
84	MP0003698_abnormal_male_reproductive	0.90957897
85	MP0001986_abnormal_taste_sensitivity	0.90766819
86	MP0005187_abnormal_penis_morphology	0.90239568
87	MP0002938_white_spotting	0.90082877
88	MP0003861_abnormal_nervous_system	0.88311241
89	MP0001963_abnormal_hearing_physiology	0.87360759
90	MP0002733_abnormal_thermal_nociception	0.87035934
91	MP0005248_abnormal_Harderian_gland	0.86933736
92	MP0002229_neurodegeneration	0.86639578
93	MP0008058_abnormal_DNA_repair	0.86378577
94	MP0005391_vision/eye_phenotype	0.82798697
95	MP0003119_abnormal_digestive_system	0.78576211
96	MP0002069_abnormal_eating/drinking_beha	0.78107243
97	MP0002066_abnormal_motor_capabilities/c	0.75032785
98	MP0003938_abnormal_ear_development	0.74752572
99	MP0003755_abnormal_palate_morphology	0.74304776
100	MP0001929_abnormal_gametogenesis	0.73970158

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	4.05811805
2	Pancreatic fibrosis (HP:0100732)	3.98754945
3	Abnormality of midbrain morphology (HP:0002418)	3.88821050
4	Molar tooth sign on MRI (HP:0002419)	3.88821050
5	True hermaphroditism (HP:0010459)	3.80254036
6	Abnormal respiratory motile cilium morphology (HP:0005938)	3.70209567
7	Abnormal respiratory epithelium morphology (HP:0012253)	3.70209567
8	Medial flaring of the eyebrow (HP:0010747)	3.67127139
9	Pancreatic cysts (HP:0001737)	3.62440609
10	Abnormal ciliary motility (HP:0012262)	3.55042914
11	Gait imbalance (HP:0002141)	3.38331324
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.36583815
13	Abnormality of the renal medulla (HP:0100957)	3.35288409
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.34880375
15	Focal motor seizures (HP:0011153)	3.26842708
16	Congenital primary aphakia (HP:0007707)	3.21218667
17	Absent/shortened dynein arms (HP:0200106)	3.20603900
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.20603900
19	Chronic hepatic failure (HP:0100626)	3.15743593
20	Rhinitis (HP:0012384)	3.08643294
21	Nephrogenic diabetes insipidus (HP:0009806)	2.98232229
22	Focal seizures (HP:0007359)	2.94936515
23	Hyperglycinemia (HP:0002154)	2.86542676
24	Gaze-evoked nystagmus (HP:0000640)	2.77101932
25	Genital tract atresia (HP:0001827)	2.76908061
26	Polyphagia (HP:0002591)	2.72117038
27	Abnormality of the labia minora (HP:0012880)	2.70232686
28	Tubulointerstitial nephritis (HP:0001970)	2.67010023
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57644264
30	Postaxial foot polydactyly (HP:0001830)	2.55273876
31	Occipital encephalocele (HP:0002085)	2.52879755
32	Vaginal atresia (HP:0000148)	2.52366221
33	Colon cancer (HP:0003003)	2.52312274
34	Drooling (HP:0002307)	2.51965214
35	Postaxial hand polydactyly (HP:0001162)	2.49957543
36	Genetic anticipation (HP:0003743)	2.47229341
37	Pachygyria (HP:0001302)	2.43484462
38	Methylmalonic acidemia (HP:0002912)	2.41273600
39	Broad-based gait (HP:0002136)	2.40732148
40	Amyotrophic lateral sclerosis (HP:0007354)	2.36666190
41	Progressive cerebellar ataxia (HP:0002073)	2.36461768
42	Lissencephaly (HP:0001339)	2.36020027
43	Hyperventilation (HP:0002883)	2.35971868
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.34486634
45	Cystic liver disease (HP:0006706)	2.34234088
46	Poor coordination (HP:0002370)	2.31203079
47	Excessive salivation (HP:0003781)	2.28378012
48	Abnormality of the renal cortex (HP:0011035)	2.26800042
49	Congenital hepatic fibrosis (HP:0002612)	2.21520706
50	Failure to thrive in infancy (HP:0001531)	2.18452308
51	Short tibia (HP:0005736)	2.17545725
52	Febrile seizures (HP:0002373)	2.16524867
53	Intestinal atresia (HP:0011100)	2.13536505
54	Specific learning disability (HP:0001328)	2.10517131
55	Anencephaly (HP:0002323)	2.08560595
56	Sclerocornea (HP:0000647)	2.05588269
57	Tubular atrophy (HP:0000092)	2.05586028
58	Dyskinesia (HP:0100660)	2.05282850
59	Progressive inability to walk (HP:0002505)	2.04262706
60	Hepatoblastoma (HP:0002884)	2.01794504
61	Narrow forehead (HP:0000341)	2.00945744
62	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00140714
63	Abnormality of glycine metabolism (HP:0010895)	2.00140714
64	Polyuria (HP:0000103)	1.98539308
65	Abnormal drinking behavior (HP:0030082)	1.98057632
66	Polydipsia (HP:0001959)	1.98057632
67	Hemiparesis (HP:0001269)	1.96803238
68	Inability to walk (HP:0002540)	1.96061175
69	Dysdiadochokinesis (HP:0002075)	1.94867191
70	Volvulus (HP:0002580)	1.93023525
71	Broad foot (HP:0001769)	1.90531185
72	Preaxial hand polydactyly (HP:0001177)	1.90071460
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89369847
74	Hyperglycinuria (HP:0003108)	1.88473078
75	Renal hypoplasia (HP:0000089)	1.87596729
76	Thyroid-stimulating hormone excess (HP:0002925)	1.86816575
77	Prominent nasal bridge (HP:0000426)	1.85954028
78	Methylmalonic aciduria (HP:0012120)	1.85497952
79	Chronic bronchitis (HP:0004469)	1.85306022
80	Oligodactyly (hands) (HP:0001180)	1.85037855
81	Abolished electroretinogram (ERG) (HP:0000550)	1.84928666
82	Absent speech (HP:0001344)	1.84587344
83	Labial hypoplasia (HP:0000066)	1.82941203
84	Hypsarrhythmia (HP:0002521)	1.81521765
85	Bronchiectasis (HP:0002110)	1.81395464
86	Asplenia (HP:0001746)	1.78825282
87	Tubulointerstitial abnormality (HP:0001969)	1.78525296
88	Abnormal biliary tract physiology (HP:0012439)	1.78333679
89	Bile duct proliferation (HP:0001408)	1.78333679
90	Short foot (HP:0001773)	1.76222592
91	Supernumerary spleens (HP:0009799)	1.75941278
92	Agitation (HP:0000713)	1.75833100
93	Congenital stationary night blindness (HP:0007642)	1.74616982
94	Attenuation of retinal blood vessels (HP:0007843)	1.74497506
95	Oculomotor apraxia (HP:0000657)	1.73994245
96	EEG with generalized epileptiform discharges (HP:0011198)	1.72793448
97	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70594827
98	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70594827
99	Micropenis (HP:0000054)	1.70172291
100	Thyroiditis (HP:0100646)	1.69587810

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.46541677
2	MAP4K2	3.62593132
3	MARK1	3.25044486
4	WNK3	3.11715867
5	CASK	2.79019793
6	MAP3K4	2.71065634
7	NTRK2	2.39807673
8	TRIM28	2.25557307
9	BCR	2.24732870
10	BMPR1B	2.14768854
11	MAP2K7	2.05962192
12	EPHA4	1.89204043
13	DYRK2	1.81197762
14	ADRBK2	1.80461608
15	MAPK13	1.73776909
16	CSNK1G2	1.73047692
17	PINK1	1.70063293
18	ERBB3	1.61519954
19	CSNK1G3	1.59379773
20	PAK3	1.56256346
21	CSNK1A1L	1.49890336
22	CSNK1G1	1.45299585
23	EPHA3	1.36802161
24	DYRK3	1.35398912
25	CDK19	1.31416446
26	CAMKK2	1.30911655
27	GRK1	1.29902408
28	ACVR1B	1.29674044
29	NUAK1	1.20299644
30	TNIK	1.18663431
31	FGFR2	1.17647873
32	ZAK	1.14241818
33	PHKG1	1.09091874
34	PHKG2	1.09091874
35	BCKDK	1.06778678
36	DAPK2	1.03495285
37	NTRK3	1.03475567
38	MAPK15	1.02525453
39	PRKCE	1.00272167
40	STK16	0.98124738
41	MAP2K4	0.95772617
42	INSRR	0.93819177
43	PRKCG	0.93511976
44	STK3	0.93128391
45	WNK4	0.91460924
46	DYRK1A	0.91066368
47	TYRO3	0.90829185
48	STK38L	0.89914239
49	MKNK2	0.86295928
50	PRKCZ	0.78175318
51	MINK1	0.75270503
52	RPS6KA4	0.74603632
53	OBSCN	0.71352171
54	FER	0.69939679
55	YES1	0.68664767
56	PLK2	0.67732660
57	UHMK1	0.66792313
58	SGK2	0.66691876
59	MKNK1	0.66581055
60	PKN1	0.66233134
61	DYRK1B	0.66032049
62	STK11	0.65300755
63	CAMK2A	0.65070138
64	AKT3	0.64228359
65	SGK494	0.63822009
66	SGK223	0.63822009
67	OXSR1	0.63563639
68	CDK5	0.62868886
69	CSNK1D	0.62105989
70	SIK2	0.62041132
71	CAMK4	0.60957626
72	PTK2B	0.59078533
73	TAOK3	0.57342613
74	PLK4	0.55601527
75	PAK6	0.55195524
76	PRKACA	0.54254854
77	ADRBK1	0.53969347
78	NLK	0.53363073
79	STK39	0.48906391
80	PRKAA1	0.46863576
81	EPHB2	0.45300343
82	BRD4	0.43255901
83	ERBB2	0.41603890
84	MUSK	0.39738827
85	CAMK1	0.39267666
86	SRPK1	0.39134147
87	CSNK1A1	0.38844436
88	BRSK2	0.38343139
89	TNK2	0.37361360
90	FES	0.36517948
91	TGFBR1	0.36461708
92	PRKG1	0.35953138
93	ATM	0.35585575
94	MAP3K7	0.33167366
95	CDK3	0.33044901
96	PRKACG	0.32783405
97	TIE1	0.32466301
98	PRKD3	0.30575009
99	EGFR	0.30490952
100	PRKACB	0.30295662

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.61912303
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60451793
3	Nicotine addiction_Homo sapiens_hsa05033	2.58768129
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.52744524
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42341603
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26368419
7	beta-Alanine metabolism_Homo sapiens_hsa00410	2.06391677
8	Butanoate metabolism_Homo sapiens_hsa00650	2.02729112
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97988613
10	Phototransduction_Homo sapiens_hsa04744	1.95566075
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95426138
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.79740586
13	Olfactory transduction_Homo sapiens_hsa04740	1.75861774
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74837290
15	GABAergic synapse_Homo sapiens_hsa04727	1.71892794
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.71634096
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70995646
18	Propanoate metabolism_Homo sapiens_hsa00640	1.66382626
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.66150915
20	Basal transcription factors_Homo sapiens_hsa03022	1.63188685
21	Regulation of autophagy_Homo sapiens_hsa04140	1.61029597
22	Peroxisome_Homo sapiens_hsa04146	1.59652333
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.59593803
24	Circadian entrainment_Homo sapiens_hsa04713	1.58063673
25	Taste transduction_Homo sapiens_hsa04742	1.56635672
26	Circadian rhythm_Homo sapiens_hsa04710	1.54662503
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.50728589
28	Insulin secretion_Homo sapiens_hsa04911	1.47211135
29	Morphine addiction_Homo sapiens_hsa05032	1.44976246
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.41626805
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39789943
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.35532874
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32750305
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.29721435
35	Axon guidance_Homo sapiens_hsa04360	1.27330421
36	Cocaine addiction_Homo sapiens_hsa05030	1.26944561
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.26120682
38	Dopaminergic synapse_Homo sapiens_hsa04728	1.25325742
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24613596
40	Protein export_Homo sapiens_hsa03060	1.18088301
41	Serotonergic synapse_Homo sapiens_hsa04726	1.17517646
42	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.14185719
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13820287
44	RNA degradation_Homo sapiens_hsa03018	1.13339063
45	Salivary secretion_Homo sapiens_hsa04970	1.08935142
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06508909
47	Caffeine metabolism_Homo sapiens_hsa00232	1.03686211
48	Non-homologous end-joining_Homo sapiens_hsa03450	1.01867773
49	Retinol metabolism_Homo sapiens_hsa00830	0.99403719
50	Cholinergic synapse_Homo sapiens_hsa04725	0.98486995
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96268719
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.95676821
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.95120873
54	Amphetamine addiction_Homo sapiens_hsa05031	0.94108811
55	Fatty acid elongation_Homo sapiens_hsa00062	0.91185686
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.90441022
57	RNA polymerase_Homo sapiens_hsa03020	0.89703355
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.89438246
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89340831
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88928076
61	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84327318
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84114857
63	Huntingtons disease_Homo sapiens_hsa05016	0.83400816
64	Histidine metabolism_Homo sapiens_hsa00340	0.82496422
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80428341
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78947331
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78291102
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75579364
69	ABC transporters_Homo sapiens_hsa02010	0.75485297
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.71175523
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.71137863
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68015984
73	Long-term depression_Homo sapiens_hsa04730	0.66689443
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.65712092
75	Parkinsons disease_Homo sapiens_hsa05012	0.63653102
76	Renin secretion_Homo sapiens_hsa04924	0.62033730
77	Fatty acid degradation_Homo sapiens_hsa00071	0.61449363
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58463788
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.58022535
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56985988
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56885079
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55676231
83	Sulfur metabolism_Homo sapiens_hsa00920	0.55077143
84	Oocyte meiosis_Homo sapiens_hsa04114	0.54061876
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53934663
86	Alcoholism_Homo sapiens_hsa05034	0.52891509
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.52619686
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.52242559
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52187394
90	Gastric acid secretion_Homo sapiens_hsa04971	0.51695908
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51510841
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.48819094
93	Metabolic pathways_Homo sapiens_hsa01100	0.48546686
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47734483
95	Gap junction_Homo sapiens_hsa04540	0.43384079
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.43102092
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42942839
98	Purine metabolism_Homo sapiens_hsa00230	0.42055075
99	Homologous recombination_Homo sapiens_hsa03440	0.38572784
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37519399

ZNF606

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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