ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore organization (GO:0006999)	3.56877931
2	nuclear pore complex assembly (GO:0051292)	3.55701628
3	chromatin remodeling at centromere (GO:0031055)	3.52770604
4	paraxial mesoderm development (GO:0048339)	3.51300760
5	CENP-A containing nucleosome assembly (GO:0034080)	3.38986550
6	single strand break repair (GO:0000012)	3.17635583
7	establishment of integrated proviral latency (GO:0075713)	3.15756220
8	protein localization to kinetochore (GO:0034501)	3.09004109
9	DNA ligation (GO:0006266)	3.07522153
10	histone exchange (GO:0043486)	3.06498843
11	DNA replication checkpoint (GO:0000076)	3.01111161
12	microtubule depolymerization (GO:0007019)	2.99487096
13	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.96596568
14	DNA replication-independent nucleosome assembly (GO:0006336)	2.95124695
15	DNA replication-independent nucleosome organization (GO:0034724)	2.95124695
16	mitotic metaphase plate congression (GO:0007080)	2.91914368
17	regulation of cilium movement (GO:0003352)	2.88876970
18	DNA strand elongation involved in DNA replication (GO:0006271)	2.88218162
19	intraciliary transport (GO:0042073)	2.87413115
20	DNA replication-dependent nucleosome organization (GO:0034723)	2.83331510
21	DNA replication-dependent nucleosome assembly (GO:0006335)	2.83331510
22	DNA strand elongation (GO:0022616)	2.81208413
23	pre-miRNA processing (GO:0031054)	2.79880598
24	pyrimidine nucleobase catabolic process (GO:0006208)	2.79488211
25	protein localization to chromosome, centromeric region (GO:0071459)	2.77216980
26	double-strand break repair via nonhomologous end joining (GO:0006303)	2.76786615
27	non-recombinational repair (GO:0000726)	2.76786615
28	mitotic sister chromatid cohesion (GO:0007064)	2.72252734
29	regulation of gene silencing by RNA (GO:0060966)	2.71163690
30	regulation of posttranscriptional gene silencing (GO:0060147)	2.71163690
31	regulation of gene silencing by miRNA (GO:0060964)	2.71163690
32	microtubule anchoring (GO:0034453)	2.70853750
33	sister chromatid segregation (GO:0000819)	2.70712730
34	telomere maintenance via semi-conservative replication (GO:0032201)	2.67483601
35	mitotic sister chromatid segregation (GO:0000070)	2.66300805
36	regulation of centrosome cycle (GO:0046605)	2.65371771
37	negative regulation of chromosome segregation (GO:0051985)	2.62866790
38	resolution of meiotic recombination intermediates (GO:0000712)	2.62211849
39	histone-serine phosphorylation (GO:0035404)	2.59592546
40	spindle checkpoint (GO:0031577)	2.58694388
41	centriole replication (GO:0007099)	2.58124246
42	mitotic spindle checkpoint (GO:0071174)	2.57183888
43	mitochondrial RNA metabolic process (GO:0000959)	2.55713052
44	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.55443987
45	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.55443987
46	negative regulation of sister chromatid segregation (GO:0033046)	2.55443987
47	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.55443987
48	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.55443987
49	pore complex assembly (GO:0046931)	2.52796948
50	regulation of centrosome duplication (GO:0010824)	2.52566214
51	metaphase plate congression (GO:0051310)	2.52536019
52	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52254973
53	rRNA modification (GO:0000154)	2.52210808
54	DNA integration (GO:0015074)	2.51599826
55	mitotic chromosome condensation (GO:0007076)	2.51069722
56	microtubule polymerization or depolymerization (GO:0031109)	2.50834302
57	regulation of centriole replication (GO:0046599)	2.49123600
58	ATP-dependent chromatin remodeling (GO:0043044)	2.47641046
59	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.47126493
60	organ growth (GO:0035265)	2.45556574
61	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.45042147
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.45042147
63	regulation of mitotic spindle checkpoint (GO:1903504)	2.42845055
64	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.42845055
65	regulation of chromosome segregation (GO:0051983)	2.42211529
66	rRNA methylation (GO:0031167)	2.41110747
67	DNA replication initiation (GO:0006270)	2.40565343
68	establishment of mitochondrion localization (GO:0051654)	2.39236469
69	mitotic spindle assembly checkpoint (GO:0007094)	2.39060466
70	DNA unwinding involved in DNA replication (GO:0006268)	2.37959588
71	regulation of sister chromatid segregation (GO:0033045)	2.34553825
72	regulation of mitotic sister chromatid separation (GO:0010965)	2.34553825
73	regulation of mitotic sister chromatid segregation (GO:0033047)	2.34553825
74	histone arginine methylation (GO:0034969)	2.34059504
75	regulation of helicase activity (GO:0051095)	2.33972499
76	spindle assembly checkpoint (GO:0071173)	2.33387298
77	7-methylguanosine mRNA capping (GO:0006370)	2.33215912
78	cholesterol biosynthetic process (GO:0006695)	2.32682103
79	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.31485959
80	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.31485959
81	spliceosomal snRNP assembly (GO:0000387)	2.31452141
82	regulation of DNA methylation (GO:0044030)	2.31402150
83	heterochromatin organization (GO:0070828)	2.30860872
84	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.30627673
85	regulation of DNA endoreduplication (GO:0032875)	2.30279509
86	protein polyglutamylation (GO:0018095)	2.30155546
87	histone mRNA metabolic process (GO:0008334)	2.30024977
88	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.29802157
89	binding of sperm to zona pellucida (GO:0007339)	2.28670494
90	mitotic recombination (GO:0006312)	2.28352688
91	mitotic nuclear envelope disassembly (GO:0007077)	2.28021034
92	transcription-coupled nucleotide-excision repair (GO:0006283)	2.26505104
93	telomere maintenance via recombination (GO:0000722)	2.26145504
94	amino acid activation (GO:0043038)	2.25920698
95	tRNA aminoacylation (GO:0043039)	2.25920698
96	7-methylguanosine RNA capping (GO:0009452)	2.25874045
97	RNA capping (GO:0036260)	2.25874045
98	protein localization to chromosome (GO:0034502)	2.25701172
99	histone H2A acetylation (GO:0043968)	2.25379407
100	base-excision repair (GO:0006284)	2.25284542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.53893882
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04290289
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.94432444
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.92657460
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.86829665
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.84389958
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.63427806
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.61569481
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.60900257
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53693698
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.45863774
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.42788363
13	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.34898646
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34607138
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26769507
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.23156142
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22426005
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14573381
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13968143
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.09322248
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.08539528
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.00313858
23	FUS_26573619_Chip-Seq_HEK293_Human	1.96528118
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.96112680
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89427251
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.89268904
27	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.84956739
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.84047845
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.81792487
30	EWS_26573619_Chip-Seq_HEK293_Human	1.80857473
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.79576322
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.76972927
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.72690651
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.69768079
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69409745
36	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.67451036
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.67053090
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.64093945
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.60206781
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.59953845
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59751606
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56763894
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.54342252
44	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.53858443
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.51909906
46	AR_21909140_ChIP-Seq_LNCAP_Human	1.51857681
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.50887201
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49979652
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.49875272
50	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.47979109
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.46588466
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.43098406
53	GBX2_23144817_ChIP-Seq_PC3_Human	1.42698617
54	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.42427849
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39410844
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.37703504
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.36528550
58	* NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34554462
59	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.34202952
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33914288
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.33448706
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32764480
63	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.31260562
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.31159941
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23726940
66	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.23583517
67	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.23457432
68	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22310252
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.22106648
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.18106798
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16618871
72	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12524533
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12503142
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12216935
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10542539
76	VDR_22108803_ChIP-Seq_LS180_Human	1.07489756
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.06929195
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06370863
79	* P300_19829295_ChIP-Seq_ESCs_Human	1.05358191
80	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03706493
81	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.02602655
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02437018
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97998317
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97755728
85	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97321572
86	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.96335006
87	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.92621310
88	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.91598681
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91558675
90	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.89958130
91	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.88833564
92	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.88004893
93	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.87214410
94	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.85680780
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85007430
96	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.84944643
97	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.84012947
98	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.83277464
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.82587487
100	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.80340018

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	2.92531347
2	MP0010094_abnormal_chromosome_stability	2.54901810
3	MP0006292_abnormal_olfactory_placode	2.47098570
4	MP0003890_abnormal_embryonic-extraembry	2.43145809
5	MP0008058_abnormal_DNA_repair	2.40286755
6	MP0003111_abnormal_nucleus_morphology	2.30252252
7	MP0004957_abnormal_blastocyst_morpholog	2.28563944
8	MP0001529_abnormal_vocalization	2.23253257
9	MP0008877_abnormal_DNA_methylation	2.19887832
10	MP0003718_maternal_effect	2.14680337
11	MP0001984_abnormal_olfaction	2.12159362
12	MP0008932_abnormal_embryonic_tissue	2.10323240
13	MP0003937_abnormal_limbs/digits/tail_de	2.07554683
14	MP0001293_anophthalmia	2.02483610
15	MP0003077_abnormal_cell_cycle	1.99649101
16	MP0000579_abnormal_nail_morphology	1.94163760
17	MP0003315_abnormal_perineum_morphology	1.93665341
18	MP0008057_abnormal_DNA_replication	1.92417716
19	MP0008789_abnormal_olfactory_epithelium	1.90417196
20	MP0001188_hyperpigmentation	1.79565113
21	MP0005394_taste/olfaction_phenotype	1.76558742
22	MP0005499_abnormal_olfactory_system	1.76558742
23	MP0005187_abnormal_penis_morphology	1.75099939
24	MP0002249_abnormal_larynx_morphology	1.69406661
25	MP0003122_maternal_imprinting	1.67015472
26	MP0003136_yellow_coat_color	1.58890698
27	MP0003942_abnormal_urinary_system	1.58183864
28	MP0006276_abnormal_autonomic_nervous	1.55958614
29	MP0000778_abnormal_nervous_system	1.51130189
30	MP0004133_heterotaxia	1.47766068
31	MP0003646_muscle_fatigue	1.43115890
32	MP0003121_genomic_imprinting	1.42530627
33	MP0002234_abnormal_pharynx_morphology	1.41077024
34	MP0010030_abnormal_orbit_morphology	1.39774223
35	MP0002697_abnormal_eye_size	1.39066004
36	MP0002084_abnormal_developmental_patter	1.38184313
37	MP0002233_abnormal_nose_morphology	1.34472831
38	MP0002085_abnormal_embryonic_tissue	1.34415436
39	MP0003861_abnormal_nervous_system	1.34138501
40	MP0001730_embryonic_growth_arrest	1.33503550
41	MP0001286_abnormal_eye_development	1.31633410
42	MP0003787_abnormal_imprinting	1.31602928
43	MP0003941_abnormal_skin_development	1.31081148
44	MP0000537_abnormal_urethra_morphology	1.30283371
45	MP0001929_abnormal_gametogenesis	1.28366406
46	MP0008007_abnormal_cellular_replicative	1.28230392
47	MP0002282_abnormal_trachea_morphology	1.28017329
48	MP0002822_catalepsy	1.27371419
49	MP0000049_abnormal_middle_ear	1.26133809
50	MP0002102_abnormal_ear_morphology	1.25303267
51	MP0003123_paternal_imprinting	1.20950716
52	MP0004270_analgesia	1.17804685
53	MP0003119_abnormal_digestive_system	1.16839592
54	MP0005380_embryogenesis_phenotype	1.12447846
55	MP0001672_abnormal_embryogenesis/_devel	1.12447846
56	MP0005410_abnormal_fertilization	1.11811862
57	MP0002638_abnormal_pupillary_reflex	1.11376375
58	MP0002210_abnormal_sex_determination	1.11238881
59	MP0002160_abnormal_reproductive_system	1.10582444
60	MP0003755_abnormal_palate_morphology	1.10374224
61	MP0000631_abnormal_neuroendocrine_gland	1.09490079
62	MP0001697_abnormal_embryo_size	1.09184768
63	MP0003698_abnormal_male_reproductive	1.09157242
64	MP0002938_white_spotting	1.04143639
65	MP0000955_abnormal_spinal_cord	1.03693289
66	MP0002736_abnormal_nociception_after	1.02572619
67	MP0002751_abnormal_autonomic_nervous	1.02471853
68	MP0002184_abnormal_innervation	1.01676233
69	MP0000653_abnormal_sex_gland	0.97009593
70	MP0002092_abnormal_eye_morphology	0.95610803
71	MP0001145_abnormal_male_reproductive	0.94839556
72	MP0002734_abnormal_mechanical_nocicepti	0.94292113
73	MP0003880_abnormal_central_pattern	0.92891961
74	MP0009672_abnormal_birth_weight	0.92698012
75	MP0004197_abnormal_fetal_growth/weight/	0.92387427
76	MP0003935_abnormal_craniofacial_develop	0.90844290
77	MP0003984_embryonic_growth_retardation	0.90567471
78	MP0001968_abnormal_touch/_nociception	0.89766500
79	MP0000350_abnormal_cell_proliferation	0.89654558
80	MP0009703_decreased_birth_body	0.89568064
81	MP0002152_abnormal_brain_morphology	0.89014191
82	MP0004859_abnormal_synaptic_plasticity	0.88998314
83	MP0001299_abnormal_eye_distance/	0.88810959
84	MP0004145_abnormal_muscle_electrophysio	0.88409376
85	MP0002088_abnormal_embryonic_growth/wei	0.88066609
86	MP0002161_abnormal_fertility/fecundity	0.87320390
87	MP0000566_synostosis	0.82965912
88	MP0004811_abnormal_neuron_physiology	0.82660320
89	MP0002080_prenatal_lethality	0.82502511
90	MP0003567_abnormal_fetal_cardiomyocyte	0.79325546
91	MP0003385_abnormal_body_wall	0.78715523
92	MP0005391_vision/eye_phenotype	0.78623516
93	MP0002116_abnormal_craniofacial_bone	0.78149626
94	MP0002752_abnormal_somatic_nervous	0.76108603
95	MP0002111_abnormal_tail_morphology	0.75484311
96	MP0002081_perinatal_lethality	0.74299717
97	MP0004142_abnormal_muscle_tone	0.73788301
98	MP0002557_abnormal_social/conspecific_i	0.73221281
99	MP0002653_abnormal_ependyma_morphology	0.72816552
100	MP0001661_extended_life_span	0.72353607

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	2.99127834
2	Colon cancer (HP:0003003)	2.89383401
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.78084828
4	Cortical dysplasia (HP:0002539)	2.62928538
5	Abnormal lung lobation (HP:0002101)	2.58739050
6	Hepatoblastoma (HP:0002884)	2.55084761
7	Chromsome breakage (HP:0040012)	2.45369179
8	Type II lissencephaly (HP:0007260)	2.40837962
9	Facial cleft (HP:0002006)	2.40803443
10	Meckel diverticulum (HP:0002245)	2.33968018
11	Pancreatic fibrosis (HP:0100732)	2.27522247
12	Nephroblastoma (Wilms tumor) (HP:0002667)	2.26642680
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.26117539
14	Abnormality of the ileum (HP:0001549)	2.25327800
15	Bicornuate uterus (HP:0000813)	2.24346874
16	Cerebellar dysplasia (HP:0007033)	2.23866831
17	Medial flaring of the eyebrow (HP:0010747)	2.23708774
18	Abnormality of chromosome stability (HP:0003220)	2.23123748
19	Lipid accumulation in hepatocytes (HP:0006561)	2.23118229
20	Increased hepatocellular lipid droplets (HP:0006565)	2.22806814
21	Genital tract atresia (HP:0001827)	2.18558418
22	Vaginal atresia (HP:0000148)	2.16341779
23	Bifid tongue (HP:0010297)	2.15691578
24	Septo-optic dysplasia (HP:0100842)	2.13123313
25	Retinal dysplasia (HP:0007973)	2.12807018
26	Embryonal renal neoplasm (HP:0011794)	2.10891375
27	Gait imbalance (HP:0002141)	2.09347276
28	Increased nuchal translucency (HP:0010880)	2.07160930
29	Supernumerary spleens (HP:0009799)	2.06164678
30	Abnormality of cochlea (HP:0000375)	2.04210136
31	Congenital primary aphakia (HP:0007707)	2.02118385
32	Impulsivity (HP:0100710)	2.00660642
33	Poor coordination (HP:0002370)	2.00610611
34	Chronic hepatic failure (HP:0100626)	2.00447157
35	Volvulus (HP:0002580)	1.99590447
36	Septate vagina (HP:0001153)	1.98817469
37	Sloping forehead (HP:0000340)	1.97816113
38	Hyperglycinuria (HP:0003108)	1.96246990
39	Nephrogenic diabetes insipidus (HP:0009806)	1.94875413
40	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.94807944
41	Pancreatic cysts (HP:0001737)	1.94386349
42	Partial agenesis of the corpus callosum (HP:0001338)	1.93807595
43	True hermaphroditism (HP:0010459)	1.90375305
44	Hyperglycinemia (HP:0002154)	1.89880902
45	Tubulointerstitial nephritis (HP:0001970)	1.89297515
46	Lissencephaly (HP:0001339)	1.85656431
47	Medulloblastoma (HP:0002885)	1.84343858
48	High anterior hairline (HP:0009890)	1.84080045
49	Triphalangeal thumb (HP:0001199)	1.83369289
50	Oligodactyly (hands) (HP:0001180)	1.81572586
51	Abnormality of the preputium (HP:0100587)	1.81082439
52	Small intestinal stenosis (HP:0012848)	1.80649086
53	Duodenal stenosis (HP:0100867)	1.80649086
54	Intestinal atresia (HP:0011100)	1.79587060
55	Reticulocytopenia (HP:0001896)	1.79398324
56	Hepatocellular necrosis (HP:0001404)	1.77867686
57	Preaxial hand polydactyly (HP:0001177)	1.77692932
58	Chronic bronchitis (HP:0004469)	1.77108154
59	Morphological abnormality of the inner ear (HP:0011390)	1.75537224
60	Postaxial foot polydactyly (HP:0001830)	1.73799868
61	Occipital encephalocele (HP:0002085)	1.73750107
62	Drooling (HP:0002307)	1.73451680
63	Nephronophthisis (HP:0000090)	1.73074006
64	Embryonal neoplasm (HP:0002898)	1.72808963
65	Abnormality of glycine metabolism (HP:0010895)	1.72673104
66	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72673104
67	Median cleft lip (HP:0000161)	1.69837106
68	Postaxial hand polydactyly (HP:0001162)	1.68681204
69	Abnormality of the duodenum (HP:0002246)	1.68094069
70	Anophthalmia (HP:0000528)	1.66139374
71	Microvesicular hepatic steatosis (HP:0001414)	1.65858421
72	Dandy-Walker malformation (HP:0001305)	1.65652285
73	Absent eyebrow (HP:0002223)	1.65594291
74	Facial hemangioma (HP:0000329)	1.64468988
75	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.63800455
76	Multicystic kidney dysplasia (HP:0000003)	1.63627074
77	Midline defect of the nose (HP:0004122)	1.63315311
78	Horseshoe kidney (HP:0000085)	1.62966084
79	Abdominal situs inversus (HP:0003363)	1.62533858
80	Abnormality of abdominal situs (HP:0011620)	1.62533858
81	Abnormality of the carotid arteries (HP:0005344)	1.60743369
82	Oligodactyly (HP:0012165)	1.58934379
83	Short tibia (HP:0005736)	1.57868494
84	Micropenis (HP:0000054)	1.56726204
85	Ectopic kidney (HP:0000086)	1.56211131
86	Bilateral microphthalmos (HP:0007633)	1.55058034
87	Broad foot (HP:0001769)	1.54707556
88	Scrotal hypoplasia (HP:0000046)	1.54322559
89	Rhinitis (HP:0012384)	1.54108114
90	Absent radius (HP:0003974)	1.53002696
91	Optic nerve coloboma (HP:0000588)	1.52737180
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.52428565
93	Abnormality of the metopic suture (HP:0005556)	1.51464319
94	Degeneration of anterior horn cells (HP:0002398)	1.51106607
95	Abnormality of the anterior horn cell (HP:0006802)	1.51106607
96	Duplication of thumb phalanx (HP:0009942)	1.49500412
97	Renal dysplasia (HP:0000110)	1.49408518
98	Sclerocornea (HP:0000647)	1.49077283
99	Abnormality of the renal medulla (HP:0100957)	1.49001913
100	Aplasia involving forearm bones (HP:0009822)	1.48955440

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SRPK1	3.18064076
2	TRIM28	2.72932495
3	MAP3K4	2.68316925
4	TSSK6	2.62422026
5	CASK	2.62066703
6	TTK	2.47413178
7	MAP2K7	2.45358179
8	NEK1	2.44705531
9	CDC7	2.38653168
10	ZAK	2.21953387
11	STK38L	2.21852148
12	BUB1	2.10652175
13	PBK	2.08080919
14	BCR	1.98142672
15	TNIK	1.93346735
16	PLK4	1.82625714
17	PLK1	1.67738034
18	WNK3	1.64977693
19	BRD4	1.64569742
20	BRSK2	1.63238876
21	PNCK	1.62160717
22	PLK3	1.55921657
23	CSNK1G1	1.55636077
24	DYRK2	1.52574629
25	PASK	1.44998537
26	CSNK1G2	1.44735850
27	CSNK1A1L	1.44325470
28	WEE1	1.37209760
29	CSNK1G3	1.36810508
30	CDK19	1.33205718
31	MAP3K9	1.25751027
32	PRKD3	1.21826119
33	NEK2	1.19203874
34	BMPR1B	1.17752383
35	ATR	1.15645687
36	WNK4	1.08685275
37	LATS1	1.05983855
38	VRK1	1.04931877
39	BRSK1	1.04076555
40	BRAF	1.03368468
41	MKNK1	1.01993780
42	CHEK2	1.00949165
43	STK39	1.00021827
44	EIF2AK3	0.99338277
45	AURKA	0.98892686
46	DYRK3	0.98319458
47	MAP4K2	0.97635551
48	CHEK1	0.95785637
49	STK3	0.92474199
50	ATM	0.91564867
51	NTRK2	0.89904279
52	CDK7	0.86380481
53	MKNK2	0.86338520
54	CAMK1G	0.86278110
55	MAP2K4	0.83310130
56	AURKB	0.81845534
57	VRK2	0.81627897
58	AKT3	0.80862514
59	TAF1	0.80607133
60	MARK1	0.79562715
61	STK16	0.75601539
62	CDK3	0.74742615
63	PLK2	0.71062196
64	NME1	0.70285026
65	CDK1	0.67692491
66	CAMK1D	0.66856746
67	CDK2	0.66117584
68	PRKCG	0.65064942
69	CSNK1E	0.65060780
70	EPHA4	0.64881789
71	FGFR1	0.64539868
72	MAPK13	0.63804739
73	CDK12	0.62565041
74	RPS6KA4	0.62080243
75	UHMK1	0.60495197
76	MAP3K10	0.60046431
77	PRKAA1	0.59370363
78	STK24	0.57730979
79	DYRK1B	0.57684783
80	PRKCI	0.55854238
81	MAP3K7	0.55658542
82	PRKDC	0.55432205
83	STK4	0.54807239
84	IRAK1	0.51110433
85	IRAK2	0.49931306
86	ICK	0.49895191
87	BCKDK	0.48848462
88	STK11	0.48347174
89	CSNK1D	0.42810251
90	ACVR1B	0.42717701
91	CSNK2A2	0.42471342
92	OXSR1	0.42417133
93	FGFR2	0.41497005
94	NTRK1	0.40780823
95	CSNK1A1	0.40650044
96	MST4	0.40586029
97	EIF2AK2	0.40334914
98	ERBB3	0.39732601
99	TYRO3	0.39601933
100	GSK3B	0.38516084

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.01569976
2	Mismatch repair_Homo sapiens_hsa03430	2.91021080
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.71163317
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.62042544
5	Base excision repair_Homo sapiens_hsa03410	2.61724857
6	RNA transport_Homo sapiens_hsa03013	2.51436142
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.50788054
8	Basal transcription factors_Homo sapiens_hsa03022	2.50315181
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.49656353
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.41260448
11	RNA polymerase_Homo sapiens_hsa03020	2.33916441
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.24755593
13	Spliceosome_Homo sapiens_hsa03040	2.23944949
14	Cell cycle_Homo sapiens_hsa04110	2.23213447
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99451812
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.95391308
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.89127462
18	Homologous recombination_Homo sapiens_hsa03440	1.84981283
19	Protein export_Homo sapiens_hsa03060	1.71888522
20	RNA degradation_Homo sapiens_hsa03018	1.64370403
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.56887891
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.56376131
23	Basal cell carcinoma_Homo sapiens_hsa05217	1.50928773
24	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.48261864
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41945975
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41346668
27	Ribosome_Homo sapiens_hsa03010	1.38158821
28	Circadian rhythm_Homo sapiens_hsa04710	1.35513687
29	Huntingtons disease_Homo sapiens_hsa05016	1.33938261
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.31950609
31	Oocyte meiosis_Homo sapiens_hsa04114	1.29319451
32	Propanoate metabolism_Homo sapiens_hsa00640	1.22014509
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20130000
34	Hippo signaling pathway_Homo sapiens_hsa04390	1.18576099
35	Purine metabolism_Homo sapiens_hsa00230	1.15397730
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.13707803
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.10117903
38	Parkinsons disease_Homo sapiens_hsa05012	1.06101385
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.06043905
40	Wnt signaling pathway_Homo sapiens_hsa04310	1.05008208
41	Nicotine addiction_Homo sapiens_hsa05033	1.03840880
42	Regulation of autophagy_Homo sapiens_hsa04140	1.03611552
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01685152
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97334987
45	Proteasome_Homo sapiens_hsa03050	0.95582696
46	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.94408301
47	Alcoholism_Homo sapiens_hsa05034	0.90782590
48	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87542596
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86175556
50	Fatty acid elongation_Homo sapiens_hsa00062	0.74317982
51	One carbon pool by folate_Homo sapiens_hsa00670	0.73275654
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73004643
53	Olfactory transduction_Homo sapiens_hsa04740	0.72028008
54	Butanoate metabolism_Homo sapiens_hsa00650	0.70468279
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70099031
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69749540
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69087939
58	Phototransduction_Homo sapiens_hsa04744	0.68620184
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68326113
60	Taste transduction_Homo sapiens_hsa04742	0.67273860
61	p53 signaling pathway_Homo sapiens_hsa04115	0.66988706
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.66482072
63	Peroxisome_Homo sapiens_hsa04146	0.65508794
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65301387
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64641122
66	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.62361156
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58954789
68	Thyroid cancer_Homo sapiens_hsa05216	0.56272792
69	Lysine degradation_Homo sapiens_hsa00310	0.55188372
70	Axon guidance_Homo sapiens_hsa04360	0.54990695
71	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53785875
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53000442
73	Tight junction_Homo sapiens_hsa04530	0.52253084
74	Adherens junction_Homo sapiens_hsa04520	0.51691005
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50179541
76	Melanogenesis_Homo sapiens_hsa04916	0.49258508
77	Metabolic pathways_Homo sapiens_hsa01100	0.49118889
78	Alzheimers disease_Homo sapiens_hsa05010	0.46385338
79	Folate biosynthesis_Homo sapiens_hsa00790	0.45530092
80	Colorectal cancer_Homo sapiens_hsa05210	0.45398154
81	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45081786
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.37616360
83	Melanoma_Homo sapiens_hsa05218	0.36936313
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.35854000
85	AMPK signaling pathway_Homo sapiens_hsa04152	0.35744811
86	Carbon metabolism_Homo sapiens_hsa01200	0.35419044
87	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.34465804
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33854665
89	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33163216
90	GABAergic synapse_Homo sapiens_hsa04727	0.30819542
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.29352846
92	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.29185292
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.26288893
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25863036
95	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.24198126
96	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.23911913
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23323627
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.21064186
99	Insulin secretion_Homo sapiens_hsa04911	0.19834647
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.19413667

ZNF607

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »