ZNF609

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.59757133
2regulation of RNA export from nucleus (GO:0046831)4.52103326
3regulation of histone H3-K27 methylation (GO:0061085)4.39388964
4negative regulation of histone methylation (GO:0031061)4.17191425
5histone H3-K36 demethylation (GO:0070544)4.14688645
6pre-miRNA processing (GO:0031054)4.03413473
7histone H3-K4 trimethylation (GO:0080182)4.00079430
8regulation of nucleobase-containing compound transport (GO:0032239)3.80344265
9regulation of NFAT protein import into nucleus (GO:0051532)3.79171446
10cytoplasmic mRNA processing body assembly (GO:0033962)3.75535919
11glucocorticoid receptor signaling pathway (GO:0042921)3.57705277
12negative regulation of DNA repair (GO:0045738)3.55743833
13nuclear pore organization (GO:0006999)3.52850996
14histone H3-K9 demethylation (GO:0033169)3.52716962
15histone lysine demethylation (GO:0070076)3.49877852
16positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.45682653
17insulin-like growth factor receptor signaling pathway (GO:0048009)3.40068143
18negative regulation of erythrocyte differentiation (GO:0045647)3.35505034
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.31364603
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.28842561
21regulation of translation, ncRNA-mediated (GO:0045974)3.28842561
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28842561
23histone demethylation (GO:0016577)3.28638614
24histone H3-K4 methylation (GO:0051568)3.24202317
25nucleosome disassembly (GO:0006337)3.21313581
26protein-DNA complex disassembly (GO:0032986)3.21313581
27pore complex assembly (GO:0046931)3.16080150
28positive regulation of gene expression, epigenetic (GO:0045815)3.15267573
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14988635
30corticosteroid receptor signaling pathway (GO:0031958)3.14472136
31embryonic camera-type eye morphogenesis (GO:0048596)3.14051193
32regulation of histone H3-K4 methylation (GO:0051569)3.14032069
33regulation of histone methylation (GO:0031060)3.07668736
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04557805
35histone lysine methylation (GO:0034968)3.02027231
36positive regulation by host of viral transcription (GO:0043923)3.01312758
37heterochromatin organization (GO:0070828)2.96453315
38peptidyl-lysine trimethylation (GO:0018023)2.93920293
39peptidyl-threonine phosphorylation (GO:0018107)2.93849700
40histone H3-K9 methylation (GO:0051567)2.92945774
41embryonic retina morphogenesis in camera-type eye (GO:0060059)2.92351001
42neural tube development (GO:0021915)2.85309505
43protein dealkylation (GO:0008214)2.83023103
44protein demethylation (GO:0006482)2.83023103
45definitive hemopoiesis (GO:0060216)2.81730472
46focal adhesion assembly (GO:0048041)2.81660671
47cell-substrate adherens junction assembly (GO:0007045)2.81660671
48histone H3-K9 modification (GO:0061647)2.81059358
49embryonic eye morphogenesis (GO:0048048)2.80516583
50peptidyl-threonine modification (GO:0018210)2.77939087
51response to epidermal growth factor (GO:0070849)2.76314401
52mitotic sister chromatid cohesion (GO:0007064)2.71462776
53face development (GO:0060324)2.71177282
54peptidyl-lysine methylation (GO:0018022)2.70822369
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.70006305
56adherens junction assembly (GO:0034333)2.68908218
57stress granule assembly (GO:0034063)2.66815523
58interkinetic nuclear migration (GO:0022027)2.66765885
59regulation of histone H3-K9 methylation (GO:0051570)2.66132153
60histone H4-K16 acetylation (GO:0043984)2.66017731
61negative regulation of histone modification (GO:0031057)2.65417461
62histone methylation (GO:0016571)2.63321291
63NLS-bearing protein import into nucleus (GO:0006607)2.62985242
64mannose metabolic process (GO:0006013)2.62007560
65positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59260085
66positive regulation of protein import into nucleus, translocation (GO:0033160)2.58987451
67peptidyl-lysine dimethylation (GO:0018027)2.58882290
68semaphorin-plexin signaling pathway (GO:0071526)2.56086628
69protein localization to microtubule (GO:0035372)2.55313527
70establishment of nucleus localization (GO:0040023)2.52862005
71DNA topological change (GO:0006265)2.50482210
72cell-substrate junction assembly (GO:0007044)2.49611723
73camera-type eye morphogenesis (GO:0048593)2.47835463
74cellular response to epidermal growth factor stimulus (GO:0071364)2.47793271
75eye morphogenesis (GO:0048592)2.46662282
76chromatin silencing (GO:0006342)2.44313735
77RNA stabilization (GO:0043489)2.43361240
78mRNA stabilization (GO:0048255)2.43361240
79positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.42664307
80intracellular estrogen receptor signaling pathway (GO:0030520)2.41612151
81histone deubiquitination (GO:0016578)2.41432985
82heart morphogenesis (GO:0003007)2.40957363
83regulation of protein polyubiquitination (GO:1902914)2.40530182
84negative regulation of chromatin modification (GO:1903309)2.40050984
85embryonic process involved in female pregnancy (GO:0060136)2.39304199
86positive regulation of histone deacetylation (GO:0031065)2.39062545
87DNA unwinding involved in DNA replication (GO:0006268)2.38972403
88establishment of spindle orientation (GO:0051294)2.36629577
89nucleus localization (GO:0051647)2.32368861
90cell-cell junction maintenance (GO:0045217)2.28376404
91dosage compensation (GO:0007549)2.28281368
92regulation of stem cell maintenance (GO:2000036)2.27486751
93morphogenesis of an epithelial sheet (GO:0002011)2.25824214
94monoubiquitinated protein deubiquitination (GO:0035520)2.25780088
95regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.25196826
96Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.24501274
97negative regulation of gene expression, epigenetic (GO:0045814)2.23633258
98ear development (GO:0043583)2.22174377
99regulation of establishment of planar polarity (GO:0090175)2.22086306
100establishment of spindle localization (GO:0051293)2.21921787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.55602331
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.53859364
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27069045
4E2F7_22180533_ChIP-Seq_HELA_Human2.91716661
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.87454809
6TCF7_22412390_ChIP-Seq_EML_Mouse2.69960023
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.47892958
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46300447
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39128862
10DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.32070750
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30909838
12* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30014060
13KDM2B_26808549_Chip-Seq_K562_Human2.22519805
14ZFP281_27345836_Chip-Seq_ESCs_Mouse2.21475625
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.21142015
16* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20895690
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20845788
18KDM2B_26808549_Chip-Seq_DND41_Human2.19373074
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17514722
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.13445499
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.09033938
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05094693
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.04782133
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01772030
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00407368
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96532232
27VDR_21846776_ChIP-Seq_THP-1_Human1.93668831
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85056765
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.80389641
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77434313
31SCL_19346495_ChIP-Seq_HPC-7_Human1.76685558
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.72183654
33DROSHA_22980978_ChIP-Seq_HELA_Human1.68001279
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64637676
35* RUNX1_27514584_Chip-Seq_MCF-7_Human1.63718878
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63013961
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62677037
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58607389
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53457255
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50723923
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.49654396
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48846801
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48077083
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48077083
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48077083
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43486888
47GATA1_19941826_ChIP-Seq_K562_Human1.42604689
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39604254
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.39180453
50AHR_22903824_ChIP-Seq_MCF-7_Human1.38882686
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35939701
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33650558
53NCOR1_26117541_ChIP-Seq_K562_Human1.33542703
54* AR_21572438_ChIP-Seq_LNCaP_Human1.30168424
55CREB1_26743006_Chip-Seq_LNCaP_Human1.28035071
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27944679
57RACK7_27058665_Chip-Seq_MCF-7_Human1.27092485
58* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25917764
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.25309443
60VDR_24763502_ChIP-Seq_THP-1_Human1.21749280
61* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21346906
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20399088
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19741646
64* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16391667
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.16158860
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.15041632
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.14817381
68MAF_26560356_Chip-Seq_TH1_Human1.13969251
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13235699
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13062453
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.12828346
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12118224
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.11645725
74* GATA2_19941826_ChIP-Seq_K562_Human1.10902978
75* CHD1_26751641_Chip-Seq_LNCaP_Human1.10401066
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09863758
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09074732
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08008869
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06824494
80* SPI1_23127762_ChIP-Seq_K562_Human1.06586040
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02106581
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01917574
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01572541
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01371302
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00827065
86GATA1_22025678_ChIP-Seq_K562_Human1.00424431
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.99334378
88LXR_22292898_ChIP-Seq_THP-1_Human0.99101483
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96944612
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95369522
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94809766
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94347173
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.93829112
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.93645740
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92463233
96TP53_23651856_ChIP-Seq_MEFs_Mouse0.91885604
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90845070
98CLOCK_20551151_ChIP-Seq_293T_Human0.89978591
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89528606
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.89443784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.77378124
2MP0003705_abnormal_hypodermis_morpholog3.75542528
3MP0005409_darkened_coat_color3.41426330
4MP0002009_preneoplasia3.27543242
5MP0008057_abnormal_DNA_replication3.21156879
6MP0000566_synostosis2.59947855
7MP0002396_abnormal_hematopoietic_system2.59392218
8MP0004808_abnormal_hematopoietic_stem2.22920150
9MP0009278_abnormal_bone_marrow2.21647441
10MP0000569_abnormal_digit_pigmentation2.06651102
11MP0003890_abnormal_embryonic-extraembry1.96678880
12MP0000537_abnormal_urethra_morphology1.95010831
13MP0004264_abnormal_extraembryonic_tissu1.88592593
14MP0003091_abnormal_cell_migration1.88488314
15MP0002249_abnormal_larynx_morphology1.82055866
16MP0004185_abnormal_adipocyte_glucose1.79897695
17MP0000428_abnormal_craniofacial_morphol1.73219745
18MP0003566_abnormal_cell_adhesion1.63492826
19MP0009672_abnormal_birth_weight1.63362911
20MP0003984_embryonic_growth_retardation1.60986008
21MP0002088_abnormal_embryonic_growth/wei1.56783300
22MP0001849_ear_inflammation1.54098203
23MP0002166_altered_tumor_susceptibility1.51687105
24MP0003115_abnormal_respiratory_system1.50258604
25MP0009703_decreased_birth_body1.47608494
26MP0010352_gastrointestinal_tract_polyps1.46334456
27MP0003300_gastrointestinal_ulcer1.44503761
28MP0001672_abnormal_embryogenesis/_devel1.42304498
29MP0005380_embryogenesis_phenotype1.42304498
30MP0002084_abnormal_developmental_patter1.38275082
31MP0008961_abnormal_basal_metabolism1.38138920
32MP0002086_abnormal_extraembryonic_tissu1.36530875
33MP0003935_abnormal_craniofacial_develop1.33951491
34MP0002925_abnormal_cardiovascular_devel1.33931275
35MP0003943_abnormal_hepatobiliary_system1.32615729
36MP0004197_abnormal_fetal_growth/weight/1.31967861
37MP0000432_abnormal_head_morphology1.31526488
38MP0000383_abnormal_hair_follicle1.31412804
39MP0003861_abnormal_nervous_system1.30863984
40MP0002085_abnormal_embryonic_tissue1.30288851
41MP0002089_abnormal_postnatal_growth/wei1.28766006
42MP0003942_abnormal_urinary_system1.27785244
43MP0005451_abnormal_body_composition1.23334772
44MP0000350_abnormal_cell_proliferation1.23026039
45MP0003385_abnormal_body_wall1.21523605
46MP0001348_abnormal_lacrimal_gland1.20674425
47MP0002697_abnormal_eye_size1.18101025
48MP0004858_abnormal_nervous_system1.15350186
49MP0000733_abnormal_muscle_development1.15227814
50MP0000579_abnormal_nail_morphology1.14590508
51MP0010630_abnormal_cardiac_muscle1.14219601
52MP0001730_embryonic_growth_arrest1.13476077
53MP0000778_abnormal_nervous_system1.10637684
54MP0001915_intracranial_hemorrhage1.08573614
55MP0002092_abnormal_eye_morphology1.07999183
56MP0005666_abnormal_adipose_tissue1.06297993
57MP0001286_abnormal_eye_development1.05734245
58MP0003763_abnormal_thymus_physiology1.05534920
59MP0003045_fibrosis1.05457588
60MP0010678_abnormal_skin_adnexa1.03304852
61MP0005621_abnormal_cell_physiology1.03002558
62MP0002116_abnormal_craniofacial_bone1.02836110
63MP0003937_abnormal_limbs/digits/tail_de1.02675662
64MP0001697_abnormal_embryo_size1.02593121
65MP0002080_prenatal_lethality0.99248750
66MP0001299_abnormal_eye_distance/0.99089880
67MP0000703_abnormal_thymus_morphology0.97541202
68MP0000534_abnormal_ureter_morphology0.97091262
69MP0010030_abnormal_orbit_morphology0.96335486
70MP0002081_perinatal_lethality0.94580202
71MP0001545_abnormal_hematopoietic_system0.94332248
72MP0005397_hematopoietic_system_phenotyp0.94332248
73MP0000377_abnormal_hair_follicle0.93546349
74MP0004381_abnormal_hair_follicle0.92671936
75MP0003453_abnormal_keratinocyte_physiol0.92235508
76MP0003938_abnormal_ear_development0.91953561
77MP0004134_abnormal_chest_morphology0.87957683
78MP0004233_abnormal_muscle_weight0.85974633
79MP0004947_skin_inflammation0.85142094
80MP0000266_abnormal_heart_morphology0.83911419
81MP0009053_abnormal_anal_canal0.83396958
82MP0002114_abnormal_axial_skeleton0.83140206
83MP0002075_abnormal_coat/hair_pigmentati0.82406039
84MP0002006_tumorigenesis0.82269738
85MP0000462_abnormal_digestive_system0.81200702
86MP0002108_abnormal_muscle_morphology0.81018887
87MP0001784_abnormal_fluid_regulation0.80284627
88MP0003755_abnormal_palate_morphology0.80178352
89MP0005375_adipose_tissue_phenotype0.79353812
90MP0003077_abnormal_cell_cycle0.79248659
91MP0003172_abnormal_lysosome_physiology0.79213641
92MP0003828_pulmonary_edema0.79122446
93MP0010307_abnormal_tumor_latency0.78963397
94MP0002152_abnormal_brain_morphology0.75341449
95MP0002111_abnormal_tail_morphology0.74908833
96MP0003123_paternal_imprinting0.74452725
97MP0003948_abnormal_gas_homeostasis0.74441480
98MP0009115_abnormal_fat_cell0.73604881
99MP0002796_impaired_skin_barrier0.73186199
100MP0006138_congestive_heart_failure0.73022439

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.72447100
2Hyperacusis (HP:0010780)3.15500050
3Broad face (HP:0000283)3.03558890
4Long eyelashes (HP:0000527)3.02420452
5Obstructive sleep apnea (HP:0002870)2.98767303
6Heterotopia (HP:0002282)2.68205503
7Vertebral arch anomaly (HP:0008438)2.58991099
8Abnormality of the distal phalanx of the thumb (HP:0009617)2.53381709
9Dysmetric saccades (HP:0000641)2.52104894
10Macroorchidism (HP:0000053)2.51476380
11Narrow palate (HP:0000189)2.50519795
12Bronchomalacia (HP:0002780)2.48326286
13Ankyloglossia (HP:0010296)2.42764685
14Acute lymphatic leukemia (HP:0006721)2.38355041
15Urethral obstruction (HP:0000796)2.35823120
16Obsessive-compulsive behavior (HP:0000722)2.33438802
17Disproportionate tall stature (HP:0001519)2.25540034
18Shallow orbits (HP:0000586)2.22513185
19Neonatal hypoglycemia (HP:0001998)2.21861590
20Acute myeloid leukemia (HP:0004808)2.17914522
21Sandal gap (HP:0001852)2.14568294
22Renovascular hypertension (HP:0100817)2.14471572
23Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.13073483
24Flat acetabular roof (HP:0003180)2.11801275
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10516104
26Germ cell neoplasia (HP:0100728)2.09131329
27Genetic anticipation (HP:0003743)2.04876218
28Overgrowth (HP:0001548)2.04694305
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01439389
30Short 4th metacarpal (HP:0010044)2.01439389
31Broad thumb (HP:0011304)2.00510442
32Truncal obesity (HP:0001956)2.00161875
33Dislocated radial head (HP:0003083)1.97567626
34Tracheomalacia (HP:0002779)1.97185749
35Mitral valve prolapse (HP:0001634)1.96913669
36Persistence of primary teeth (HP:0006335)1.96489631
37Abnormality of the nasal septum (HP:0000419)1.95618170
38Abnormality of the radial head (HP:0003995)1.95416632
39Abnormality of oral frenula (HP:0000190)1.95141494
40Abnormality of the parietal bone (HP:0002696)1.94739105
41Patellar dislocation (HP:0002999)1.93740725
42Ulnar bowing (HP:0003031)1.92276124
43Deep palmar crease (HP:0006191)1.88721059
44Abnormality of the aortic arch (HP:0012303)1.88613731
45Trigonocephaly (HP:0000243)1.87846627
46Abnormality of incisor morphology (HP:0011063)1.87635954
47High anterior hairline (HP:0009890)1.85913548
48Arnold-Chiari malformation (HP:0002308)1.83937770
49Pointed chin (HP:0000307)1.83599045
50Anal stenosis (HP:0002025)1.82916328
51Broad palm (HP:0001169)1.82667220
52Spina bifida occulta (HP:0003298)1.82166138
53Laryngomalacia (HP:0001601)1.81054801
54Supernumerary ribs (HP:0005815)1.80339207
55Skull defect (HP:0001362)1.78292922
56Increased nuchal translucency (HP:0010880)1.77323991
57Hypoplasia of the maxilla (HP:0000327)1.76957057
58Thick eyebrow (HP:0000574)1.75957565
59Tapered finger (HP:0001182)1.72035196
60Broad phalanges of the hand (HP:0009768)1.71651056
61Bowel incontinence (HP:0002607)1.71626745
62Precocious puberty (HP:0000826)1.71144070
63Deep philtrum (HP:0002002)1.69745817
64Elfin facies (HP:0004428)1.69568884
65Cubitus valgus (HP:0002967)1.69388053
66Flat cornea (HP:0007720)1.69382760
67Low anterior hairline (HP:0000294)1.68633784
68Broad finger (HP:0001500)1.67734932
6911 pairs of ribs (HP:0000878)1.67700944
70Missing ribs (HP:0000921)1.67373530
71Abnormality of the ischium (HP:0003174)1.66997320
72Asymmetry of the thorax (HP:0001555)1.66303802
73Cerebral aneurysm (HP:0004944)1.66160895
74Prominent nose (HP:0000448)1.65310156
75Arterial tortuosity (HP:0005116)1.64858392
76Neoplasm of the heart (HP:0100544)1.63853957
77Insomnia (HP:0100785)1.63632125
78Overriding aorta (HP:0002623)1.63092430
79Smooth philtrum (HP:0000319)1.60305710
80Abnormality of the columella (HP:0009929)1.59211283
81Hypoplastic ischia (HP:0003175)1.59050741
82Abnormal hair whorl (HP:0010721)1.58770771
83Limited elbow extension (HP:0001377)1.58745124
84Sparse lateral eyebrow (HP:0005338)1.57712185
85Protruding tongue (HP:0010808)1.57420407
86Papillary thyroid carcinoma (HP:0002895)1.57242662
87Hypopigmentation of the fundus (HP:0007894)1.57211469
88Broad metatarsal (HP:0001783)1.55963876
89Long palpebral fissure (HP:0000637)1.55256873
90Sparse scalp hair (HP:0002209)1.54778708
91Hepatoblastoma (HP:0002884)1.54718223
92Dental malocclusion (HP:0000689)1.54520586
93Premature skin wrinkling (HP:0100678)1.54448257
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.53357914
95Advanced eruption of teeth (HP:0006288)1.52789813
96Supernumerary bones of the axial skeleton (HP:0009144)1.52551316
97Relative macrocephaly (HP:0004482)1.52188639
98Cutis marmorata (HP:0000965)1.50361641
99Subacute progressive viral hepatitis (HP:0006572)1.49141645
100Abnormality of the incisor (HP:0000676)1.46822011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.06578310
2EEF2K3.79922847
3TRIB33.73186134
4MAP3K103.10273833
5ICK3.04735750
6CAMK1G2.98368517
7CAMK1D2.96691095
8BRD42.16925292
9SMG12.13038987
10PRPF4B2.10094049
11SIK11.89988391
12FGFR41.79555511
13MTOR1.76820685
14MARK21.74357755
15AKT31.68440185
16LATS11.62892441
17WNK11.52503039
18PKN21.52191693
19TYRO31.43327356
20FGFR31.41853616
21SGK21.41529537
22PDGFRA1.37706052
23SIK21.37040337
24SGK31.36826558
25PNCK1.34195779
26MAP3K71.31036317
27FGFR21.21739596
28KSR21.10769854
29SGK2231.03871709
30SGK4941.03871709
31MAP3K131.02831191
32TTN1.00041445
33PDGFRB0.99078777
34RET0.97423659
35LATS20.96016296
36HIPK20.95012649
37RPS6KA20.92640431
38RPS6KB20.89549986
39MAPK150.89040065
40CDK40.87133459
41TRPM70.86850945
42PTK60.85946204
43MAP2K20.84908317
44MAP3K20.84838235
45NTRK30.84738341
46RIPK40.83304385
47CDC42BPA0.80910265
48NLK0.79243635
49KSR10.76888770
50NTRK10.74736129
51MELK0.73538117
52RIPK10.71802705
53RPS6KC10.71638106
54RPS6KL10.71638106
55CDK60.68882555
56PASK0.65889444
57TNIK0.63580594
58MAP3K90.63284872
59ERBB20.60369571
60PAK20.60203261
61CHUK0.59596516
62MAPK100.59492517
63RPS6KA60.58064199
64SGK10.56585477
65STK110.54165711
66NEK20.53819323
67CHEK10.52876473
68MAPK80.52516331
69BTK0.52325519
70CAMK40.52096887
71GSK3B0.51859699
72PRKCH0.49827788
73CDC70.49128481
74* CDK20.48650902
75MAP3K60.48248934
76STK380.48204745
77TAF10.48180776
78CDK70.48048117
79YES10.47645207
80PRKD30.46682188
81AKT10.46671040
82PRKD20.46242924
83CDK10.45513673
84MAPK10.44988233
85RPS6KA10.42063132
86FGFR10.41813409
87CAMKK10.40823359
88CDK90.40326797
89DMPK0.40093040
90MAPK140.39433410
91RAF10.38929829
92RPS6KB10.38920837
93ITK0.38414512
94CASK0.38153062
95PRKAA10.37826284
96MAPK70.37395199
97STK30.37343727
98CLK10.34634627
99PRKAA20.34361992
100TAOK10.33797777

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.36634053
2Notch signaling pathway_Homo sapiens_hsa043302.06050351
3Endometrial cancer_Homo sapiens_hsa052132.03067418
4Non-small cell lung cancer_Homo sapiens_hsa052232.02862460
5Acute myeloid leukemia_Homo sapiens_hsa052212.00131820
6Lysine degradation_Homo sapiens_hsa003101.85490180
7ErbB signaling pathway_Homo sapiens_hsa040121.84480091
8Renal cell carcinoma_Homo sapiens_hsa052111.76087700
9Prostate cancer_Homo sapiens_hsa052151.75764557
10MicroRNAs in cancer_Homo sapiens_hsa052061.74671972
11Thyroid hormone signaling pathway_Homo sapiens_hsa049191.72063604
12Colorectal cancer_Homo sapiens_hsa052101.69932389
13Adherens junction_Homo sapiens_hsa045201.68667996
14Thyroid cancer_Homo sapiens_hsa052161.68318996
15Pancreatic cancer_Homo sapiens_hsa052121.60988405
16B cell receptor signaling pathway_Homo sapiens_hsa046621.54453096
17mTOR signaling pathway_Homo sapiens_hsa041501.54335220
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47953818
19VEGF signaling pathway_Homo sapiens_hsa043701.46991608
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46262622
21Glioma_Homo sapiens_hsa052141.45340295
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44133984
23Estrogen signaling pathway_Homo sapiens_hsa049151.38985669
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38719426
25Prolactin signaling pathway_Homo sapiens_hsa049171.38497952
26Dorso-ventral axis formation_Homo sapiens_hsa043201.37310995
27Choline metabolism in cancer_Homo sapiens_hsa052311.36742083
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.35414049
29Inositol phosphate metabolism_Homo sapiens_hsa005621.30793478
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23081581
31Small cell lung cancer_Homo sapiens_hsa052221.20243370
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.18990490
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.17976660
34Basal cell carcinoma_Homo sapiens_hsa052171.17905185
35GnRH signaling pathway_Homo sapiens_hsa049121.17879236
36Focal adhesion_Homo sapiens_hsa045101.16235934
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16052126
38FoxO signaling pathway_Homo sapiens_hsa040681.12084187
39Type II diabetes mellitus_Homo sapiens_hsa049301.11698816
40Long-term potentiation_Homo sapiens_hsa047201.10322798
41T cell receptor signaling pathway_Homo sapiens_hsa046601.07815886
42mRNA surveillance pathway_Homo sapiens_hsa030151.06462631
43Proteoglycans in cancer_Homo sapiens_hsa052051.05172732
44Insulin signaling pathway_Homo sapiens_hsa049101.03252023
45Hepatitis B_Homo sapiens_hsa051611.02454402
46Melanogenesis_Homo sapiens_hsa049161.00485106
47Pathways in cancer_Homo sapiens_hsa052000.98582284
48Wnt signaling pathway_Homo sapiens_hsa043100.98003492
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93747972
50Axon guidance_Homo sapiens_hsa043600.93501745
51Bladder cancer_Homo sapiens_hsa052190.93120400
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92784038
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89925872
54Platelet activation_Homo sapiens_hsa046110.89334004
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89153236
56MAPK signaling pathway_Homo sapiens_hsa040100.88531368
57Insulin resistance_Homo sapiens_hsa049310.87587823
58Hippo signaling pathway_Homo sapiens_hsa043900.86891040
59ECM-receptor interaction_Homo sapiens_hsa045120.84885563
60Hedgehog signaling pathway_Homo sapiens_hsa043400.84512933
61AMPK signaling pathway_Homo sapiens_hsa041520.81061958
62Long-term depression_Homo sapiens_hsa047300.80879792
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80803314
64Cholinergic synapse_Homo sapiens_hsa047250.79453363
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79197400
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78638429
67Viral carcinogenesis_Homo sapiens_hsa052030.78360750
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78313549
69Gap junction_Homo sapiens_hsa045400.76302059
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75114710
71Rap1 signaling pathway_Homo sapiens_hsa040150.74674506
72Melanoma_Homo sapiens_hsa052180.74244245
73HTLV-I infection_Homo sapiens_hsa051660.73692338
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.73191092
75Amoebiasis_Homo sapiens_hsa051460.71744029
76HIF-1 signaling pathway_Homo sapiens_hsa040660.70643361
77Hepatitis C_Homo sapiens_hsa051600.69306925
78Tight junction_Homo sapiens_hsa045300.69297004
79Thyroid hormone synthesis_Homo sapiens_hsa049180.69258134
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68041199
81Cell cycle_Homo sapiens_hsa041100.67831414
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.64353304
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.63791758
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63600884
85Ras signaling pathway_Homo sapiens_hsa040140.62628610
86Oxytocin signaling pathway_Homo sapiens_hsa049210.61844786
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61782607
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59614747
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.58868681
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58442052
91Influenza A_Homo sapiens_hsa051640.58402839
92Measles_Homo sapiens_hsa051620.56833564
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56650864
94TGF-beta signaling pathway_Homo sapiens_hsa043500.56002021
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55564016
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54467878
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54122574
98Toxoplasmosis_Homo sapiens_hsa051450.53131986
99cAMP signaling pathway_Homo sapiens_hsa040240.53108621
100Fatty acid biosynthesis_Homo sapiens_hsa000610.52542600

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