ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.99650439
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.91420352
3	positive regulation of mitochondrial fission (GO:0090141)	4.08679904
4	nucleobase catabolic process (GO:0046113)	3.92538593
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.88155475
6	epithelial cilium movement (GO:0003351)	3.68894354
7	response to pheromone (GO:0019236)	3.63429538
8	neuronal action potential propagation (GO:0019227)	3.60454218
9	retinal cone cell development (GO:0046549)	3.60156453
10	presynaptic membrane assembly (GO:0097105)	3.49593779
11	protein polyglutamylation (GO:0018095)	3.41216483
12	intraciliary transport (GO:0042073)	3.40528108
13	postsynaptic membrane organization (GO:0001941)	3.40196928
14	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.30837300
15	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.30837300
16	nonmotile primary cilium assembly (GO:0035058)	3.30383225
17	piRNA metabolic process (GO:0034587)	3.27898888
18	protein localization to cilium (GO:0061512)	3.26181167
19	platelet dense granule organization (GO:0060155)	3.25463925
20	protein localization to synapse (GO:0035418)	3.25035702
21	cilium morphogenesis (GO:0060271)	3.23065355
22	regulation of cilium movement (GO:0003352)	3.20439779
23	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.16348201
24	gamma-aminobutyric acid transport (GO:0015812)	3.15359218
25	presynaptic membrane organization (GO:0097090)	3.14264907
26	regulation of timing of cell differentiation (GO:0048505)	3.13040810
27	axoneme assembly (GO:0035082)	3.09629980
28	regulation of meiosis I (GO:0060631)	3.06678068
29	regulation of development, heterochronic (GO:0040034)	3.05082268
30	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.03831479
31	somite development (GO:0061053)	3.01984929
32	cilium organization (GO:0044782)	3.01287738
33	neural tube formation (GO:0001841)	2.99473821
34	L-fucose catabolic process (GO:0042355)	2.97688946
35	fucose catabolic process (GO:0019317)	2.97688946
36	L-fucose metabolic process (GO:0042354)	2.97688946
37	protein-cofactor linkage (GO:0018065)	2.95153908
38	cilium assembly (GO:0042384)	2.94540346
39	detection of light stimulus involved in visual perception (GO:0050908)	2.93555988
40	detection of light stimulus involved in sensory perception (GO:0050962)	2.93555988
41	limb bud formation (GO:0060174)	2.92215273
42	DNA deamination (GO:0045006)	2.92125591
43	cilium movement (GO:0003341)	2.91066030
44	photoreceptor cell maintenance (GO:0045494)	2.90591690
45	cornea development in camera-type eye (GO:0061303)	2.90408900
46	neuronal action potential (GO:0019228)	2.89607959
47	C4-dicarboxylate transport (GO:0015740)	2.87724654
48	spinal cord motor neuron differentiation (GO:0021522)	2.84275038
49	photoreceptor cell development (GO:0042461)	2.81731703
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81633371
51	short-term memory (GO:0007614)	2.80944470
52	ubiquinone metabolic process (GO:0006743)	2.80307600
53	regulation of mitochondrial fission (GO:0090140)	2.77551985
54	DNA integration (GO:0015074)	2.77212843
55	cullin deneddylation (GO:0010388)	2.75985417
56	sympathetic nervous system development (GO:0048485)	2.75969979
57	auditory behavior (GO:0031223)	2.73161039
58	multicellular organism reproduction (GO:0032504)	2.71112811
59	adaptation of signaling pathway (GO:0023058)	2.70521978
60	ubiquinone biosynthetic process (GO:0006744)	2.69893670
61	olfactory bulb development (GO:0021772)	2.69139389
62	reciprocal meiotic recombination (GO:0007131)	2.68742902
63	reciprocal DNA recombination (GO:0035825)	2.68742902
64	mechanosensory behavior (GO:0007638)	2.68553902
65	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.67482145
66	centriole replication (GO:0007099)	2.66941849
67	neuromuscular synaptic transmission (GO:0007274)	2.66933051
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66343160
69	neuron cell-cell adhesion (GO:0007158)	2.66269154
70	DNA double-strand break processing (GO:0000729)	2.63221927
71	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.61244992
72	transmission of nerve impulse (GO:0019226)	2.59753632
73	head development (GO:0060322)	2.59556079
74	protein complex biogenesis (GO:0070271)	2.58878346
75	reflex (GO:0060004)	2.57433582
76	synaptic transmission, cholinergic (GO:0007271)	2.56992946
77	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.55101136
78	eye photoreceptor cell development (GO:0042462)	2.54595321
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.54117948
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.54117948
81	NADH dehydrogenase complex assembly (GO:0010257)	2.54117948
82	spermatid development (GO:0007286)	2.53502405
83	cell differentiation in spinal cord (GO:0021515)	2.52738621
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50807295
85	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50635335
86	behavioral response to ethanol (GO:0048149)	2.49972902
87	regulation of action potential (GO:0098900)	2.49789477
88	GPI anchor metabolic process (GO:0006505)	2.49763028
89	mannosylation (GO:0097502)	2.49581257
90	retinal ganglion cell axon guidance (GO:0031290)	2.49005318
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.48658999
92	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.47312445
93	DNA methylation involved in gamete generation (GO:0043046)	2.46434626
94	sulfation (GO:0051923)	2.45871905
95	negative regulation of astrocyte differentiation (GO:0048712)	2.45626011
96	peristalsis (GO:0030432)	2.45363682
97	kidney morphogenesis (GO:0060993)	2.45269171
98	protein deneddylation (GO:0000338)	2.44546602
99	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.44433267
100	male meiosis I (GO:0007141)	2.43393938

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62150359
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.11056114
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.98866447
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.92165866
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88876547
6	VDR_22108803_ChIP-Seq_LS180_Human	2.72414034
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69878003
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49996491
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.37158239
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35782896
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33735085
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.30089212
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17183759
14	EWS_26573619_Chip-Seq_HEK293_Human	2.17156728
15	FUS_26573619_Chip-Seq_HEK293_Human	2.16818817
16	P300_19829295_ChIP-Seq_ESCs_Human	2.15416554
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12199278
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.12130994
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10805658
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07648156
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03421222
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90004447
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89811296
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.85531230
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82927369
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73531925
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67928166
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.65239754
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.65167621
30	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60403703
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59421482
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56894563
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55102694
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55060721
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54576957
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54576957
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.52160458
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52160458
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51706918
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50825939
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50792880
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50630253
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49200796
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48473597
45	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47890955
46	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45825584
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45320049
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44484387
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.43363344
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43232632
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42856005
52	STAT3_23295773_ChIP-Seq_U87_Human	1.41583275
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.41009389
54	AR_25329375_ChIP-Seq_VCAP_Human	1.38827076
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38798517
56	TCF4_23295773_ChIP-Seq_U87_Human	1.36505714
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34294377
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.32636315
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30346569
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29829356
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29384278
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27959733
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24798877
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24429742
65	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.24052282
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.20708581
67	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19607825
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18927456
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.18516231
70	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.18390580
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15481440
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.15355191
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14019401
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11959506
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11959506
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11818786
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11634986
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11485632
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11000545
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10741905
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09317467
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08717655
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06789656
84	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06779541
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06371524
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.05826528
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05079225
88	JUN_21703547_ChIP-Seq_K562_Human	1.04134119
89	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03264317
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03138196
91	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02200230
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00705820
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99460108
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98737559
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98444542
96	NCOR_22424771_ChIP-Seq_293T_Human	0.97027757
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96721556
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95603594
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95310432
100	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94179457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.29371918
2	MP0003880_abnormal_central_pattern	3.14874841
3	MP0002102_abnormal_ear_morphology	3.08086719
4	MP0002653_abnormal_ependyma_morphology	2.65064614
5	MP0000566_synostosis	2.40467918
6	MP0003787_abnormal_imprinting	2.39665813
7	MP0002638_abnormal_pupillary_reflex	2.37305278
8	MP0006292_abnormal_olfactory_placode	2.27669239
9	MP0005551_abnormal_eye_electrophysiolog	2.22070437
10	MP0001984_abnormal_olfaction	2.18017481
11	MP0008789_abnormal_olfactory_epithelium	2.17092361
12	MP0001968_abnormal_touch/_nociception	2.14265246
13	MP0005499_abnormal_olfactory_system	2.03848499
14	MP0005394_taste/olfaction_phenotype	2.03848499
15	MP0003122_maternal_imprinting	1.90147799
16	MP0001529_abnormal_vocalization	1.84892339
17	MP0002751_abnormal_autonomic_nervous	1.84619420
18	MP0006276_abnormal_autonomic_nervous	1.81639207
19	MP0005253_abnormal_eye_physiology	1.80895797
20	MP0002272_abnormal_nervous_system	1.80212965
21	MP0002234_abnormal_pharynx_morphology	1.76588212
22	MP0006072_abnormal_retinal_apoptosis	1.76249493
23	MP0004147_increased_porphyrin_level	1.74943462
24	MP0002736_abnormal_nociception_after	1.73918504
25	MP0009046_muscle_twitch	1.72743202
26	MP0000778_abnormal_nervous_system	1.72588087
27	MP0003121_genomic_imprinting	1.71183717
28	MP0005646_abnormal_pituitary_gland	1.71055977
29	MP0004885_abnormal_endolymph	1.70213791
30	MP0009745_abnormal_behavioral_response	1.70007627
31	MP0000631_abnormal_neuroendocrine_gland	1.62395356
32	MP0002735_abnormal_chemical_nociception	1.59246435
33	MP0002938_white_spotting	1.58866488
34	MP0002837_dystrophic_cardiac_calcinosis	1.58383365
35	MP0004133_heterotaxia	1.53198932
36	MP0005645_abnormal_hypothalamus_physiol	1.52859885
37	MP0003136_yellow_coat_color	1.49514509
38	MP0002572_abnormal_emotion/affect_behav	1.46861246
39	MP0003011_delayed_dark_adaptation	1.42703969
40	MP0002822_catalepsy	1.41984568
41	MP0000049_abnormal_middle_ear	1.41952770
42	MP0000569_abnormal_digit_pigmentation	1.41292423
43	MP0001486_abnormal_startle_reflex	1.40022244
44	MP0001485_abnormal_pinna_reflex	1.37321975
45	MP0002557_abnormal_social/conspecific_i	1.36069502
46	MP0003635_abnormal_synaptic_transmissio	1.36031861
47	MP0001293_anophthalmia	1.34931626
48	MP0002064_seizures	1.31189550
49	MP0003567_abnormal_fetal_cardiomyocyte	1.29303353
50	MP0000372_irregular_coat_pigmentation	1.28133090
51	MP0002063_abnormal_learning/memory/cond	1.24687333
52	MP0000427_abnormal_hair_cycle	1.24258222
53	MP0004142_abnormal_muscle_tone	1.22406432
54	MP0005386_behavior/neurological_phenoty	1.21812468
55	MP0004924_abnormal_behavior	1.21812468
56	MP0002067_abnormal_sensory_capabilities	1.21299114
57	MP0005171_absent_coat_pigmentation	1.20745572
58	MP0004742_abnormal_vestibular_system	1.16891635
59	MP0003195_calcinosis	1.14791880
60	MP0008872_abnormal_physiological_respon	1.14576592
61	MP0002876_abnormal_thyroid_physiology	1.13272188
62	MP0002752_abnormal_somatic_nervous	1.11146819
63	MP0002734_abnormal_mechanical_nocicepti	1.09810795
64	MP0005423_abnormal_somatic_nervous	1.09431047
65	MP0001986_abnormal_taste_sensitivity	1.08977918
66	MP0003718_maternal_effect	1.08458165
67	MP0001970_abnormal_pain_threshold	1.08430185
68	MP0010386_abnormal_urinary_bladder	1.08145837
69	MP0001501_abnormal_sleep_pattern	1.07253839
70	MP0008875_abnormal_xenobiotic_pharmacok	1.05683705
71	MP0003698_abnormal_male_reproductive	1.04869923
72	MP0000026_abnormal_inner_ear	1.04402708
73	MP0002233_abnormal_nose_morphology	1.04380587
74	MP0003937_abnormal_limbs/digits/tail_de	1.01860174
75	MP0005410_abnormal_fertilization	1.01072331
76	MP0002733_abnormal_thermal_nociception	1.00477396
77	MP0000955_abnormal_spinal_cord	1.00057314
78	MP0005195_abnormal_posterior_eye	0.99910349
79	MP0001963_abnormal_hearing_physiology	0.99614600
80	MP0001929_abnormal_gametogenesis	0.99453956
81	MP0002882_abnormal_neuron_morphology	0.98660993
82	MP0004859_abnormal_synaptic_plasticity	0.98142955
83	MP0002210_abnormal_sex_determination	0.96788121
84	MP0002184_abnormal_innervation	0.95738974
85	MP0009697_abnormal_copulation	0.94896121
86	MP0003119_abnormal_digestive_system	0.93964664
87	MP0005391_vision/eye_phenotype	0.93125624
88	MP0000647_abnormal_sebaceous_gland	0.89935131
89	MP0008058_abnormal_DNA_repair	0.88172960
90	MP0003890_abnormal_embryonic-extraembry	0.86872259
91	MP0004145_abnormal_muscle_electrophysio	0.86150015
92	MP0000653_abnormal_sex_gland	0.85388464
93	MP0005085_abnormal_gallbladder_physiolo	0.83093256
94	MP0002928_abnormal_bile_duct	0.80967102
95	MP0001324_abnormal_eye_pigmentation	0.80913267
96	MP0001502_abnormal_circadian_rhythm	0.80291179
97	MP0003646_muscle_fatigue	0.80015700
98	MP0000383_abnormal_hair_follicle	0.78814550
99	MP0000538_abnormal_urinary_bladder	0.78093852
100	MP0001145_abnormal_male_reproductive	0.78059478

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.71794840
2	Pancreatic cysts (HP:0001737)	4.55553704
3	True hermaphroditism (HP:0010459)	4.33855856
4	Pancreatic fibrosis (HP:0100732)	4.31015349
5	Nephronophthisis (HP:0000090)	3.77854746
6	Abnormality of midbrain morphology (HP:0002418)	3.52963257
7	Molar tooth sign on MRI (HP:0002419)	3.52963257
8	Medial flaring of the eyebrow (HP:0010747)	3.43649159
9	Congenital stationary night blindness (HP:0007642)	3.34957611
10	Abnormality of the renal medulla (HP:0100957)	3.17888412
11	Gait imbalance (HP:0002141)	3.10588271
12	Cystic liver disease (HP:0006706)	3.03057418
13	Congenital primary aphakia (HP:0007707)	3.01139178
14	Type II lissencephaly (HP:0007260)	2.92759779
15	Focal motor seizures (HP:0011153)	2.92732329
16	Abnormality of the labia minora (HP:0012880)	2.86847012
17	Abnormality of the renal cortex (HP:0011035)	2.80410686
18	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.79065036
19	Methylmalonic aciduria (HP:0012120)	2.78646709
20	Nephrogenic diabetes insipidus (HP:0009806)	2.74295002
21	Chronic hepatic failure (HP:0100626)	2.67280180
22	Sclerocornea (HP:0000647)	2.66198518
23	Optic nerve hypoplasia (HP:0000609)	2.64137542
24	Genital tract atresia (HP:0001827)	2.63699697
25	Anencephaly (HP:0002323)	2.61356384
26	Vaginal atresia (HP:0000148)	2.57551849
27	Attenuation of retinal blood vessels (HP:0007843)	2.48345155
28	Febrile seizures (HP:0002373)	2.47407215
29	Colon cancer (HP:0003003)	2.45729144
30	Intestinal atresia (HP:0011100)	2.42858854
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42442342
32	Abnormal biliary tract physiology (HP:0012439)	2.41483127
33	Bile duct proliferation (HP:0001408)	2.41483127
34	Postaxial foot polydactyly (HP:0001830)	2.41466165
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.35722293
36	Broad-based gait (HP:0002136)	2.34893754
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.34197363
38	Abolished electroretinogram (ERG) (HP:0000550)	2.30892349
39	Renal cortical cysts (HP:0000803)	2.29019796
40	Pendular nystagmus (HP:0012043)	2.27849937
41	Lissencephaly (HP:0001339)	2.25862454
42	Inability to walk (HP:0002540)	2.25104589
43	Progressive inability to walk (HP:0002505)	2.24990740
44	Postaxial hand polydactyly (HP:0001162)	2.24854436
45	Occipital encephalocele (HP:0002085)	2.20924126
46	Cerebellar dysplasia (HP:0007033)	2.18724338
47	Focal seizures (HP:0007359)	2.17971095
48	Congenital hepatic fibrosis (HP:0002612)	2.15472568
49	Supernumerary spleens (HP:0009799)	2.14094057
50	Tubular atrophy (HP:0000092)	2.11675223
51	Humeroradial synostosis (HP:0003041)	2.10941588
52	Synostosis involving the elbow (HP:0003938)	2.10941588
53	Absent speech (HP:0001344)	2.10299383
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08167280
55	Polyphagia (HP:0002591)	2.08157973
56	Male pseudohermaphroditism (HP:0000037)	2.07940551
57	Tubulointerstitial nephritis (HP:0001970)	2.06609117
58	Keratoconus (HP:0000563)	2.03196088
59	Increased corneal curvature (HP:0100692)	2.03196088
60	Hyperglycinemia (HP:0002154)	2.02035850
61	Hemiparesis (HP:0001269)	2.01559798
62	Pachygyria (HP:0001302)	1.99720255
63	Furrowed tongue (HP:0000221)	1.99353468
64	Decreased central vision (HP:0007663)	1.98504530
65	Polydipsia (HP:0001959)	1.95482366
66	Abnormal drinking behavior (HP:0030082)	1.95482366
67	Limb dystonia (HP:0002451)	1.93790286
68	Preaxial hand polydactyly (HP:0001177)	1.93385374
69	3-Methylglutaconic aciduria (HP:0003535)	1.93037492
70	Short tibia (HP:0005736)	1.92806858
71	Poor coordination (HP:0002370)	1.92094063
72	Retinal dysplasia (HP:0007973)	1.90287019
73	Acute necrotizing encephalopathy (HP:0006965)	1.87598441
74	Hyperglycinuria (HP:0003108)	1.86194200
75	Atonic seizures (HP:0010819)	1.85968129
76	Narrow forehead (HP:0000341)	1.84778649
77	Volvulus (HP:0002580)	1.84563893
78	Gaze-evoked nystagmus (HP:0000640)	1.84029655
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.83693643
80	Drooling (HP:0002307)	1.83692350
81	Septo-optic dysplasia (HP:0100842)	1.83339513
82	Broad foot (HP:0001769)	1.81312177
83	Specific learning disability (HP:0001328)	1.81284752
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79839742
85	Abnormal respiratory epithelium morphology (HP:0012253)	1.79839742
86	Absent/shortened dynein arms (HP:0200106)	1.77433873
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.77433873
88	Progressive cerebellar ataxia (HP:0002073)	1.75845853
89	Acute encephalopathy (HP:0006846)	1.75642966
90	Dandy-Walker malformation (HP:0001305)	1.75281533
91	Bifid tongue (HP:0010297)	1.73858259
92	Tubulointerstitial abnormality (HP:0001969)	1.72362264
93	Astigmatism (HP:0000483)	1.71098090
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.70877891
95	Rib fusion (HP:0000902)	1.70800504
96	Retinitis pigmentosa (HP:0000510)	1.69217173
97	Patellar aplasia (HP:0006443)	1.69047068
98	Small hand (HP:0200055)	1.68902158
99	Mitochondrial inheritance (HP:0001427)	1.68625695
100	Short foot (HP:0001773)	1.67221734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.25093309
2	CASK	3.54873089
3	WNK3	3.19845229
4	FRK	3.11924076
5	MAP3K4	2.95593367
6	MARK1	2.49921631
7	BMPR1B	2.28947467
8	ADRBK2	2.22247094
9	MAPK13	2.13359367
10	BCR	2.05600871
11	GRK1	2.05395408
12	TRIM28	1.99147063
13	ZAK	1.95532393
14	NUAK1	1.94285157
15	CSNK1G3	1.84481614
16	DYRK2	1.83857448
17	CSNK1G2	1.81950880
18	WNK4	1.69493161
19	TNIK	1.69450630
20	CSNK1G1	1.67274085
21	CSNK1A1L	1.64703207
22	DYRK3	1.61446623
23	INSRR	1.58144121
24	EPHA4	1.57482630
25	PINK1	1.55125295
26	MAP2K7	1.45680719
27	ACVR1B	1.38768742
28	PNCK	1.25468946
29	STK39	1.21909039
30	PLK2	1.21699883
31	PAK3	1.20480832
32	SRPK1	1.18503902
33	STK38L	1.13154019
34	TLK1	1.06602833
35	TIE1	1.03238834
36	NTRK3	1.02197161
37	BCKDK	1.01022932
38	CDK19	0.99020899
39	MKNK2	0.98594626
40	PRKCG	0.95485739
41	CDK8	0.95242708
42	ERBB3	0.94992743
43	MKNK1	0.94861453
44	PRKCE	0.93972588
45	DAPK2	0.89125065
46	CAMKK2	0.88737120
47	NTRK2	0.88234271
48	VRK1	0.87996391
49	TXK	0.87329363
50	FLT3	0.86522096
51	RPS6KA4	0.85156778
52	TGFBR1	0.81668260
53	TAOK3	0.73119291
54	ADRBK1	0.72698942
55	WEE1	0.72561080
56	OXSR1	0.71804647
57	GRK7	0.70677193
58	BRSK2	0.65551482
59	PKN1	0.64263895
60	GRK5	0.62593012
61	PLK3	0.61958553
62	MUSK	0.61627476
63	MINK1	0.61060495
64	DYRK1A	0.59713581
65	DYRK1B	0.55224560
66	CAMK2A	0.54689678
67	PLK4	0.53065326
68	CSNK1A1	0.52672190
69	KSR1	0.51508266
70	VRK2	0.51225847
71	EIF2AK3	0.50535037
72	MAPK15	0.49777431
73	CAMK1	0.47811598
74	PHKG1	0.47642006
75	PHKG2	0.47642006
76	CSNK1D	0.46638926
77	RPS6KA5	0.46137984
78	EPHA3	0.45178800
79	PRKCI	0.44557055
80	PRKACA	0.43985651
81	OBSCN	0.43582784
82	PLK1	0.43122665
83	CDK5	0.42690291
84	PAK6	0.41349685
85	PRKCZ	0.39777152
86	ATR	0.38957305
87	CAMK4	0.38636484
88	PRKG1	0.36423088
89	FER	0.36111000
90	PTK2B	0.34757599
91	CCNB1	0.34393490
92	CDK3	0.33883099
93	ATM	0.33469230
94	PRKD3	0.32772846
95	STK11	0.29817886
96	BRD4	0.28353920
97	TAF1	0.28311522
98	SGK494	0.27590715
99	SGK223	0.27590715
100	MAP2K4	0.27131749

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15010794
2	Phototransduction_Homo sapiens_hsa04744	2.86278249
3	Propanoate metabolism_Homo sapiens_hsa00640	2.85993713
4	Nicotine addiction_Homo sapiens_hsa05033	2.70742355
5	Protein export_Homo sapiens_hsa03060	2.62719598
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38991974
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.37954581
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37601140
9	Butanoate metabolism_Homo sapiens_hsa00650	2.14160018
10	Basal transcription factors_Homo sapiens_hsa03022	2.12506750
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.11303001
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.93356939
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90720564
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.88845060
15	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.84276328
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81278749
17	Parkinsons disease_Homo sapiens_hsa05012	1.81088825
18	RNA polymerase_Homo sapiens_hsa03020	1.79110374
19	Regulation of autophagy_Homo sapiens_hsa04140	1.76461739
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75186314
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73318987
22	Caffeine metabolism_Homo sapiens_hsa00232	1.65276644
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65173320
24	RNA degradation_Homo sapiens_hsa03018	1.62920260
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59593316
26	Taste transduction_Homo sapiens_hsa04742	1.48665000
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48321229
28	GABAergic synapse_Homo sapiens_hsa04727	1.47357769
29	Morphine addiction_Homo sapiens_hsa05032	1.43957155
30	Huntingtons disease_Homo sapiens_hsa05016	1.39162974
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35320870
32	Olfactory transduction_Homo sapiens_hsa04740	1.35236765
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30397449
34	Homologous recombination_Homo sapiens_hsa03440	1.30329524
35	Peroxisome_Homo sapiens_hsa04146	1.28854266
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25821456
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.23250073
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.15001675
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07058804
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.03196779
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.01175895
42	Circadian entrainment_Homo sapiens_hsa04713	0.99953688
43	Alzheimers disease_Homo sapiens_hsa05010	0.99629519
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99117969
45	Dopaminergic synapse_Homo sapiens_hsa04728	0.97647434
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97589894
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.92714821
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92689059
49	ABC transporters_Homo sapiens_hsa02010	0.91040869
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90360910
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88617244
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.88255017
53	Retinol metabolism_Homo sapiens_hsa00830	0.88235631
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87660072
55	Base excision repair_Homo sapiens_hsa03410	0.85077910
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83601317
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83392242
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77878147
59	Serotonergic synapse_Homo sapiens_hsa04726	0.75966866
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73024449
61	Insulin secretion_Homo sapiens_hsa04911	0.71697297
62	Purine metabolism_Homo sapiens_hsa00230	0.70097716
63	Metabolic pathways_Homo sapiens_hsa01100	0.67570458
64	Proteasome_Homo sapiens_hsa03050	0.67004778
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.64583415
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64143306
67	Mismatch repair_Homo sapiens_hsa03430	0.64113347
68	Fatty acid elongation_Homo sapiens_hsa00062	0.62827407
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.60748703
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59761195
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59378122
72	Cocaine addiction_Homo sapiens_hsa05030	0.58198321
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57436885
74	Salivary secretion_Homo sapiens_hsa04970	0.57268924
75	Axon guidance_Homo sapiens_hsa04360	0.56761317
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55332434
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55136825
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.54271138
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.53924767
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51921836
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51891518
82	RNA transport_Homo sapiens_hsa03013	0.51720232
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50564191
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47956677
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.47890054
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47029819
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45493509
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43567845
89	Amphetamine addiction_Homo sapiens_hsa05031	0.42442293
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42337666
91	Oocyte meiosis_Homo sapiens_hsa04114	0.41430087
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39297144
93	Circadian rhythm_Homo sapiens_hsa04710	0.38251000
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37697945
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35995875
96	Fatty acid degradation_Homo sapiens_hsa00071	0.35090324
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.33320493
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.31817602
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.30585279
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30552379

ZNF610

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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