ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.98544056
2	neural tube formation (GO:0001841)	4.59340979
3	DNA deamination (GO:0045006)	4.27464874
4	negative regulation of mast cell activation (GO:0033004)	3.84051221
5	detection of light stimulus involved in visual perception (GO:0050908)	3.79352066
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.79352066
7	indolalkylamine metabolic process (GO:0006586)	3.75701347
8	fucose catabolic process (GO:0019317)	3.75094667
9	L-fucose metabolic process (GO:0042354)	3.75094667
10	L-fucose catabolic process (GO:0042355)	3.75094667
11	limb bud formation (GO:0060174)	3.69394245
12	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.58687828
13	gamma-aminobutyric acid transport (GO:0015812)	3.54444491
14	indole-containing compound catabolic process (GO:0042436)	3.53699021
15	indolalkylamine catabolic process (GO:0046218)	3.53699021
16	tryptophan catabolic process (GO:0006569)	3.53699021
17	preassembly of GPI anchor in ER membrane (GO:0016254)	3.53182962
18	adaptation of signaling pathway (GO:0023058)	3.40558628
19	kynurenine metabolic process (GO:0070189)	3.38445800
20	mannosylation (GO:0097502)	3.37945377
21	tryptophan metabolic process (GO:0006568)	3.33656553
22	platelet dense granule organization (GO:0060155)	3.32061117
23	protein K11-linked deubiquitination (GO:0035871)	3.29461053
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.18141407
25	centriole replication (GO:0007099)	3.14704627
26	response to pheromone (GO:0019236)	3.05577048
27	regulation of hippo signaling (GO:0035330)	3.02839833
28	sulfation (GO:0051923)	3.01955519
29	photoreceptor cell maintenance (GO:0045494)	3.00773774
30	pyrimidine nucleobase catabolic process (GO:0006208)	2.98219159
31	epithelial cilium movement (GO:0003351)	2.97540646
32	nonmotile primary cilium assembly (GO:0035058)	2.97473016
33	somite development (GO:0061053)	2.95244083
34	cornea development in camera-type eye (GO:0061303)	2.94967322
35	behavioral response to ethanol (GO:0048149)	2.92005129
36	piRNA metabolic process (GO:0034587)	2.87262042
37	indole-containing compound metabolic process (GO:0042430)	2.85757604
38	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.85728680
39	GPI anchor metabolic process (GO:0006505)	2.85267078
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83803659
41	reciprocal meiotic recombination (GO:0007131)	2.82524283
42	reciprocal DNA recombination (GO:0035825)	2.82524283
43	axoneme assembly (GO:0035082)	2.81957605
44	replication fork processing (GO:0031297)	2.81601804
45	regulation of action potential (GO:0098900)	2.80945771
46	negative regulation of telomere maintenance (GO:0032205)	2.80940485
47	S-adenosylmethionine metabolic process (GO:0046500)	2.80283305
48	establishment of protein localization to Golgi (GO:0072600)	2.78598913
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.78062319
50	pyrimidine dimer repair (GO:0006290)	2.75227603
51	regulation of mitotic spindle checkpoint (GO:1903504)	2.74804595
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.74804595
53	multicellular organism reproduction (GO:0032504)	2.74639697
54	respiratory chain complex IV assembly (GO:0008535)	2.73438484
55	retinal cone cell development (GO:0046549)	2.69722925
56	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.66906520
57	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.66906520
58	regulation of translation, ncRNA-mediated (GO:0045974)	2.66906520
59	embryonic epithelial tube formation (GO:0001838)	2.63627725
60	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63315853
61	negative regulation of systemic arterial blood pressure (GO:0003085)	2.62651076
62	cellular ketone body metabolic process (GO:0046950)	2.61721482
63	primary amino compound metabolic process (GO:1901160)	2.60555705
64	protein-cofactor linkage (GO:0018065)	2.57875799
65	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.57731125
66	regulation of telomere maintenance (GO:0032204)	2.57518120
67	DNA methylation involved in gamete generation (GO:0043046)	2.57220058
68	reflex (GO:0060004)	2.55224964
69	DNA demethylation (GO:0080111)	2.53087175
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.52463605
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.52463605
72	DNA double-strand break processing (GO:0000729)	2.52202842
73	DNA integration (GO:0015074)	2.51755727
74	protein polyglutamylation (GO:0018095)	2.51548399
75	nucleobase catabolic process (GO:0046113)	2.49758181
76	amine catabolic process (GO:0009310)	2.48485109
77	cellular biogenic amine catabolic process (GO:0042402)	2.48485109
78	cilium morphogenesis (GO:0060271)	2.48314206
79	cilium movement (GO:0003341)	2.47341947
80	photoreceptor cell development (GO:0042461)	2.45805483
81	ubiquinone biosynthetic process (GO:0006744)	2.44724705
82	cytidine metabolic process (GO:0046087)	2.44313103
83	cytidine catabolic process (GO:0006216)	2.44313103
84	cytidine deamination (GO:0009972)	2.44313103
85	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43837596
86	NADH dehydrogenase complex assembly (GO:0010257)	2.43837596
87	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43837596
88	epithelial tube formation (GO:0072175)	2.42694624
89	spinal cord motor neuron differentiation (GO:0021522)	2.42267669
90	endoderm formation (GO:0001706)	2.41572435
91	cilium organization (GO:0044782)	2.41557439
92	serotonin metabolic process (GO:0042428)	2.41099645
93	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.39199320
94	cAMP catabolic process (GO:0006198)	2.39157781
95	protein localization to cilium (GO:0061512)	2.38363095
96	neuronal action potential (GO:0019228)	2.38113900
97	ketone body metabolic process (GO:1902224)	2.38030649
98	kidney morphogenesis (GO:0060993)	2.37425682
99	ubiquinone metabolic process (GO:0006743)	2.34981258
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.33822509

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.63104984
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.25486607
3	VDR_22108803_ChIP-Seq_LS180_Human	3.22229520
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.18778967
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78900523
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60166989
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.54034570
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52240154
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35274753
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22800314
11	FUS_26573619_Chip-Seq_HEK293_Human	2.13170313
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12594126
13	P300_19829295_ChIP-Seq_ESCs_Human	2.10233866
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10047864
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.06404155
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.06389971
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06030953
18	EWS_26573619_Chip-Seq_HEK293_Human	2.03394938
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91480758
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.86101233
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81232174
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79069954
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70772502
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70770733
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70485351
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68396472
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.67128717
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67128717
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64379884
30	STAT3_23295773_ChIP-Seq_U87_Human	1.63627960
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62973897
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62905621
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61843279
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58910723
35	TCF4_23295773_ChIP-Seq_U87_Human	1.55746687
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55001491
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55001491
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.54811069
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51839717
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.49782460
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48736161
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46851897
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46254367
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45906009
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45692315
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.44089617
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.43430009
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41302000
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40451910
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39576928
51	* AR_25329375_ChIP-Seq_VCAP_Human	1.39321601
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38717340
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35723279
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35531571
55	* TCF4_22108803_ChIP-Seq_LS180_Human	1.28512148
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27722404
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26976761
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26620833
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26620833
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25052994
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22948940
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21793154
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21739764
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21480523
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20441380
66	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20322476
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19370004
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19370004
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18797397
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17807801
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16906696
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16760465
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16101979
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15812110
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15696100
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12676125
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12184338
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12047792
79	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12016023
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11080522
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08984776
82	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07346198
83	NCOR_22424771_ChIP-Seq_293T_Human	1.06764140
84	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04411514
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03988297
86	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03965241
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.03914274
88	TP53_16413492_ChIP-PET_HCT116_Human	1.02981832
89	AR_20517297_ChIP-Seq_VCAP_Human	1.02111684
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00844898
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00466262
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00261816
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99468221
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98636869
95	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98042400
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97335434
97	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.96855191
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96453620
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95977931
100	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95097403

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.32303061
2	MP0008877_abnormal_DNA_methylation	3.32298610
3	MP0002102_abnormal_ear_morphology	3.26154030
4	MP0003880_abnormal_central_pattern	2.79871464
5	MP0001968_abnormal_touch/_nociception	2.64757000
6	MP0002736_abnormal_nociception_after	2.49957203
7	MP0003195_calcinosis	2.47692605
8	MP0005551_abnormal_eye_electrophysiolog	2.29072983
9	MP0003787_abnormal_imprinting	2.20748583
10	MP0004885_abnormal_endolymph	2.18333403
11	MP0002837_dystrophic_cardiac_calcinosis	2.13427763
12	MP0005646_abnormal_pituitary_gland	2.06659492
13	MP0006072_abnormal_retinal_apoptosis	2.04146882
14	MP0008872_abnormal_physiological_respon	1.99079867
15	MP0000372_irregular_coat_pigmentation	1.97914149
16	MP0004147_increased_porphyrin_level	1.94257493
17	MP0003646_muscle_fatigue	1.89099214
18	MP0006292_abnormal_olfactory_placode	1.86499508
19	MP0006276_abnormal_autonomic_nervous	1.83981690
20	MP0004142_abnormal_muscle_tone	1.83846868
21	MP0005253_abnormal_eye_physiology	1.73856760
22	MP0009046_muscle_twitch	1.67509429
23	MP0004043_abnormal_pH_regulation	1.63119514
24	MP0001486_abnormal_startle_reflex	1.61600299
25	MP0009745_abnormal_behavioral_response	1.60796555
26	MP0005075_abnormal_melanosome_morpholog	1.60505801
27	MP0005645_abnormal_hypothalamus_physiol	1.59211104
28	MP0000427_abnormal_hair_cycle	1.56266033
29	MP0002638_abnormal_pupillary_reflex	1.51920333
30	MP0002876_abnormal_thyroid_physiology	1.49255791
31	MP0001986_abnormal_taste_sensitivity	1.49126077
32	MP0002653_abnormal_ependyma_morphology	1.45629145
33	MP0000631_abnormal_neuroendocrine_gland	1.43643297
34	MP0001984_abnormal_olfaction	1.43626772
35	MP0005174_abnormal_tail_pigmentation	1.43577661
36	MP0002272_abnormal_nervous_system	1.43453187
37	MP0003011_delayed_dark_adaptation	1.42619491
38	MP0002735_abnormal_chemical_nociception	1.40063078
39	MP0002138_abnormal_hepatobiliary_system	1.29504982
40	MP0003136_yellow_coat_color	1.28950068
41	MP0004145_abnormal_muscle_electrophysio	1.28641111
42	MP0010386_abnormal_urinary_bladder	1.26232912
43	MP0008995_early_reproductive_senescence	1.23430440
44	MP0004133_heterotaxia	1.22491453
45	MP0000015_abnormal_ear_pigmentation	1.21723368
46	MP0002928_abnormal_bile_duct	1.19576178
47	MP0002572_abnormal_emotion/affect_behav	1.18263186
48	MP0001485_abnormal_pinna_reflex	1.17420948
49	MP0005389_reproductive_system_phenotype	1.15932160
50	MP0005670_abnormal_white_adipose	1.14381871
51	MP0002095_abnormal_skin_pigmentation	1.14345352
52	MP0000383_abnormal_hair_follicle	1.10748156
53	MP0005386_behavior/neurological_phenoty	1.10261669
54	MP0004924_abnormal_behavior	1.10261669
55	MP0005367_renal/urinary_system_phenotyp	1.08242586
56	MP0000516_abnormal_urinary_system	1.08242586
57	MP0005671_abnormal_response_to	1.07106418
58	MP0003890_abnormal_embryonic-extraembry	1.06984972
59	MP0008875_abnormal_xenobiotic_pharmacok	1.06776880
60	MP0002160_abnormal_reproductive_system	1.05186606
61	MP0001501_abnormal_sleep_pattern	1.04681241
62	MP0001919_abnormal_reproductive_system	1.04020578
63	MP0004742_abnormal_vestibular_system	1.02412716
64	MP0002234_abnormal_pharynx_morphology	1.02186580
65	MP0002557_abnormal_social/conspecific_i	1.01601176
66	MP0002822_catalepsy	0.99926976
67	MP0002067_abnormal_sensory_capabilities	0.99078807
68	MP0002938_white_spotting	0.97527444
69	MP0005377_hearing/vestibular/ear_phenot	0.96277196
70	MP0003878_abnormal_ear_physiology	0.96277196
71	MP0002751_abnormal_autonomic_nervous	0.93887781
72	MP0001970_abnormal_pain_threshold	0.93545016
73	MP0003635_abnormal_synaptic_transmissio	0.92865052
74	MP0002733_abnormal_thermal_nociception	0.91701798
75	MP0000647_abnormal_sebaceous_gland	0.90604315
76	MP0001529_abnormal_vocalization	0.89704230
77	MP0002063_abnormal_learning/memory/cond	0.89131930
78	MP0003698_abnormal_male_reproductive	0.88908305
79	MP0001905_abnormal_dopamine_level	0.88419488
80	MP0000778_abnormal_nervous_system	0.86598326
81	MP0008057_abnormal_DNA_replication	0.86541923
82	MP0002184_abnormal_innervation	0.86100692
83	MP0003718_maternal_effect	0.85348069
84	MP0001764_abnormal_homeostasis	0.84538744
85	MP0002064_seizures	0.84344634
86	MP0005423_abnormal_somatic_nervous	0.83572679
87	MP0009697_abnormal_copulation	0.83416053
88	MP0008058_abnormal_DNA_repair	0.82366201
89	MP0005195_abnormal_posterior_eye	0.82292026
90	MP0002163_abnormal_gland_morphology	0.80916987
91	MP0008789_abnormal_olfactory_epithelium	0.80610979
92	MP0004130_abnormal_muscle_cell	0.79801571
93	MP0005410_abnormal_fertilization	0.79277450
94	MP0002752_abnormal_somatic_nervous	0.78155868
95	MP0008775_abnormal_heart_ventricle	0.78018658
96	MP0001188_hyperpigmentation	0.77584945
97	MP0001929_abnormal_gametogenesis	0.75446082
98	MP0001661_extended_life_span	0.73774340
99	MP0003252_abnormal_bile_duct	0.72200591
100	MP0003567_abnormal_fetal_cardiomyocyte	0.71485868

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.17495897
2	Pancreatic fibrosis (HP:0100732)	3.43322665
3	True hermaphroditism (HP:0010459)	3.39265147
4	Abnormality of midbrain morphology (HP:0002418)	3.24120318
5	Molar tooth sign on MRI (HP:0002419)	3.24120318
6	Hyperventilation (HP:0002883)	3.23110263
7	Type II lissencephaly (HP:0007260)	3.19936083
8	Abnormality of the renal cortex (HP:0011035)	3.07475581
9	Chronic hepatic failure (HP:0100626)	3.07063330
10	Nephronophthisis (HP:0000090)	3.04392070
11	Congenital stationary night blindness (HP:0007642)	3.04152446
12	Medial flaring of the eyebrow (HP:0010747)	3.02646293
13	Inability to walk (HP:0002540)	2.98506772
14	Attenuation of retinal blood vessels (HP:0007843)	2.87552707
15	Abnormality of the renal medulla (HP:0100957)	2.82671070
16	Abolished electroretinogram (ERG) (HP:0000550)	2.78187956
17	Progressive inability to walk (HP:0002505)	2.64613889
18	Protruding tongue (HP:0010808)	2.61630213
19	Abnormality of the labia minora (HP:0012880)	2.61394152
20	Gaze-evoked nystagmus (HP:0000640)	2.60381456
21	Lissencephaly (HP:0001339)	2.58600058
22	Progressive cerebellar ataxia (HP:0002073)	2.56177625
23	Renal cortical cysts (HP:0000803)	2.54890102
24	Cerebellar dysplasia (HP:0007033)	2.53944095
25	Absent speech (HP:0001344)	2.50390427
26	Decreased central vision (HP:0007663)	2.48639594
27	Gait imbalance (HP:0002141)	2.45505648
28	Retinal dysplasia (HP:0007973)	2.44926364
29	Congenital primary aphakia (HP:0007707)	2.43230865
30	Nephrogenic diabetes insipidus (HP:0009806)	2.37243868
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.31940725
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.31154438
33	Abnormality of alanine metabolism (HP:0010916)	2.31154438
34	Hyperalaninemia (HP:0003348)	2.31154438
35	Cystic liver disease (HP:0006706)	2.30009706
36	Methylmalonic acidemia (HP:0002912)	2.29229831
37	Genetic anticipation (HP:0003743)	2.28502382
38	Pendular nystagmus (HP:0012043)	2.25418852
39	Pachygyria (HP:0001302)	2.21200714
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.20968113
41	Thyroiditis (HP:0100646)	2.20740439
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16942902
43	Febrile seizures (HP:0002373)	2.14548960
44	Abnormality of macular pigmentation (HP:0008002)	2.11908922
45	Sclerocornea (HP:0000647)	2.09840348
46	Genital tract atresia (HP:0001827)	2.08840919
47	Anencephaly (HP:0002323)	2.07265123
48	Thyroid-stimulating hormone excess (HP:0002925)	2.06718711
49	Hypoplastic iliac wings (HP:0002866)	2.05917775
50	Broad-based gait (HP:0002136)	2.04459998
51	Vaginal atresia (HP:0000148)	2.03553088
52	Bony spicule pigmentary retinopathy (HP:0007737)	1.99219753
53	Congenital hepatic fibrosis (HP:0002612)	1.99048496
54	Stomatitis (HP:0010280)	1.97370965
55	Tubular atrophy (HP:0000092)	1.95663795
56	Polydipsia (HP:0001959)	1.94329692
57	Abnormal drinking behavior (HP:0030082)	1.94329692
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93579802
59	Intestinal atresia (HP:0011100)	1.92301329
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91453493
61	Fair hair (HP:0002286)	1.90581547
62	Keratoconus (HP:0000563)	1.89269516
63	Increased corneal curvature (HP:0100692)	1.89269516
64	Methylmalonic aciduria (HP:0012120)	1.87273297
65	Postaxial foot polydactyly (HP:0001830)	1.85482342
66	Poor coordination (HP:0002370)	1.85463891
67	Constricted visual fields (HP:0001133)	1.83928774
68	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.83608337
69	Postaxial hand polydactyly (HP:0001162)	1.83453716
70	Clumsiness (HP:0002312)	1.80985442
71	Decreased circulating renin level (HP:0003351)	1.79348406
72	Hypothermia (HP:0002045)	1.76757384
73	IgG deficiency (HP:0004315)	1.75823555
74	Tubulointerstitial nephritis (HP:0001970)	1.74913116
75	Stomach cancer (HP:0012126)	1.74405995
76	Occipital encephalocele (HP:0002085)	1.74344369
77	Concave nail (HP:0001598)	1.72662202
78	Abnormality of the pons (HP:0007361)	1.72062613
79	Patellar aplasia (HP:0006443)	1.71341228
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71163826
81	Absent/shortened dynein arms (HP:0200106)	1.71163826
82	Small hand (HP:0200055)	1.71149132
83	Abnormality of DNA repair (HP:0003254)	1.70557360
84	Chronic sinusitis (HP:0011109)	1.69103720
85	Hypoplasia of the pons (HP:0012110)	1.67693789
86	Male pseudohermaphroditism (HP:0000037)	1.66414680
87	Polyuria (HP:0000103)	1.65926252
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.65386185
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.65386185
90	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.64762084
91	Macroglossia (HP:0000158)	1.64669739
92	Retinitis pigmentosa (HP:0000510)	1.63619791
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.62792330
94	Abnormality of the renal collecting system (HP:0004742)	1.62737765
95	Narrow forehead (HP:0000341)	1.62625285
96	Dandy-Walker malformation (HP:0001305)	1.62165980
97	Abnormality of the metopic suture (HP:0005556)	1.62068128
98	Astigmatism (HP:0000483)	1.61995612
99	Abnormality of eosinophils (HP:0001879)	1.61370092
100	Short foot (HP:0001773)	1.60690295

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.97119838
2	MAP4K2	3.80095431
3	PINK1	3.05308363
4	ADRBK2	2.63809430
5	NUAK1	2.55789300
6	WNK3	2.52206156
7	BMPR1B	2.38377034
8	TRIM28	2.31516572
9	AKT3	2.20855330
10	MAP3K4	2.19395573
11	TXK	2.16305810
12	MAPK13	2.14297507
13	TAOK3	2.10829231
14	GRK1	2.03241970
15	ZAK	1.77291707
16	ACVR1B	1.73544402
17	MARK1	1.66429031
18	CASK	1.66006941
19	MAP2K7	1.48899418
20	PLK4	1.45025449
21	TLK1	1.42970354
22	INSRR	1.41467939
23	TNIK	1.34784587
24	OXSR1	1.25871943
25	PDK2	1.20534549
26	PLK2	1.16538464
27	WNK4	1.15917063
28	BCR	1.10605013
29	MKNK2	1.03602553
30	ADRBK1	1.03037082
31	PAK3	0.99220909
32	MARK3	0.99156833
33	PRKCE	0.91961110
34	DYRK2	0.90700134
35	SGK2	0.88093191
36	SIK2	0.85717665
37	TEC	0.85522834
38	PRKCG	0.81098407
39	STK39	0.80248205
40	STK38L	0.79892439
41	DAPK2	0.78641779
42	NLK	0.78162379
43	OBSCN	0.77766029
44	PIK3CA	0.75296818
45	CAMKK2	0.75048054
46	TNK2	0.73931134
47	CDK8	0.72774204
48	CAMK1D	0.71793570
49	TIE1	0.69435708
50	CCNB1	0.69421774
51	BRSK2	0.68948370
52	NTRK2	0.68892362
53	FGFR2	0.67562423
54	GRK7	0.67206405
55	ERBB3	0.65232791
56	CSNK1G1	0.63746958
57	SGK494	0.63714369
58	SGK223	0.63714369
59	NTRK3	0.63405063
60	BCKDK	0.59834455
61	VRK1	0.57612052
62	PRKCI	0.56036788
63	CSNK1A1L	0.56031625
64	CSNK1G2	0.55995758
65	PRKCQ	0.55839956
66	IRAK1	0.55466543
67	CSNK1G3	0.55003374
68	MAP4K1	0.51976271
69	STK11	0.51616620
70	KIT	0.50598989
71	CHUK	0.49722054
72	FER	0.48014840
73	ITK	0.47796536
74	RPS6KA5	0.47741979
75	MST4	0.47349146
76	CAMK1G	0.47322175
77	SYK	0.45843353
78	EPHA3	0.45371977
79	PNCK	0.45129081
80	CAMK1	0.44628973
81	PTK2B	0.43377743
82	PIM1	0.42779294
83	PRKACA	0.41371530
84	PRKAA2	0.41370522
85	IKBKB	0.40762346
86	CSNK1A1	0.40644349
87	PIK3CG	0.40152354
88	PRKCZ	0.39169608
89	TGFBR1	0.38713171
90	DYRK1A	0.38443413
91	CSNK1D	0.38066401
92	PKN1	0.37446297
93	MAPKAPK5	0.36929996
94	WEE1	0.36033860
95	CAMK2A	0.35569860
96	DYRK3	0.35389597
97	EIF2AK3	0.34854962
98	LCK	0.34443625
99	BTK	0.31886120
100	MKNK1	0.31815032

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.22056081
2	Phototransduction_Homo sapiens_hsa04744	2.79927221
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.77385628
4	Nicotine addiction_Homo sapiens_hsa05033	2.44168599
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43548241
6	Butanoate metabolism_Homo sapiens_hsa00650	2.37694307
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.35649937
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24636433
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.22197574
10	Basal transcription factors_Homo sapiens_hsa03022	2.10385128
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08108356
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.07550345
13	Taste transduction_Homo sapiens_hsa04742	1.89222561
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88604757
15	Caffeine metabolism_Homo sapiens_hsa00232	1.86893065
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85719813
17	Olfactory transduction_Homo sapiens_hsa04740	1.76940280
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72887950
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.69896419
20	Homologous recombination_Homo sapiens_hsa03440	1.69161803
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62271292
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.58761845
23	Protein export_Homo sapiens_hsa03060	1.57036439
24	Morphine addiction_Homo sapiens_hsa05032	1.54666062
25	ABC transporters_Homo sapiens_hsa02010	1.52655379
26	Propanoate metabolism_Homo sapiens_hsa00640	1.50913406
27	Regulation of autophagy_Homo sapiens_hsa04140	1.46405581
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.43070506
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.41044005
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.37611136
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35343762
32	RNA polymerase_Homo sapiens_hsa03020	1.33879495
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28738794
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23255066
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18560443
36	GABAergic synapse_Homo sapiens_hsa04727	1.17947552
37	Serotonergic synapse_Homo sapiens_hsa04726	1.15882852
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12799454
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11948426
40	RNA degradation_Homo sapiens_hsa03018	1.10368697
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.00792562
42	Retinol metabolism_Homo sapiens_hsa00830	1.00635427
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00446932
44	Circadian entrainment_Homo sapiens_hsa04713	1.00366303
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.97090390
46	Insulin secretion_Homo sapiens_hsa04911	0.96275497
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94400505
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.93276082
49	Peroxisome_Homo sapiens_hsa04146	0.92597757
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83836418
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.81830508
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76927823
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76582783
54	Salivary secretion_Homo sapiens_hsa04970	0.76516720
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75803897
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73371344
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73101728
58	Asthma_Homo sapiens_hsa05310	0.72308300
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71685128
60	Parkinsons disease_Homo sapiens_hsa05012	0.71252098
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70562307
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69779852
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.69605675
64	Allograft rejection_Homo sapiens_hsa05330	0.69311308
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68937418
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68227173
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.66507572
68	Sulfur metabolism_Homo sapiens_hsa00920	0.66500020
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65202929
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64936410
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.57637124
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56981826
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55939626
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55011474
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54772225
76	One carbon pool by folate_Homo sapiens_hsa00670	0.53134811
77	Purine metabolism_Homo sapiens_hsa00230	0.50573840
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50474618
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49144377
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.48766020
81	Cholinergic synapse_Homo sapiens_hsa04725	0.48698899
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48372635
83	Huntingtons disease_Homo sapiens_hsa05016	0.46801060
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46584894
85	Circadian rhythm_Homo sapiens_hsa04710	0.45368577
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44466502
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42935618
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41839927
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39476552
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36416409
91	Metabolic pathways_Homo sapiens_hsa01100	0.36090330
92	Renin secretion_Homo sapiens_hsa04924	0.35567828
93	Long-term depression_Homo sapiens_hsa04730	0.35370432
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.33628563
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32685345
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32594603
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31603891
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30977209
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30507533
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30281743

ZNF611

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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