ZNF613

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.39088456
2DNA double-strand break processing (GO:0000729)4.37499562
3regulation of mitotic spindle checkpoint (GO:1903504)3.97162388
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.97162388
5protein-cofactor linkage (GO:0018065)3.96360618
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.94896069
7NADH dehydrogenase complex assembly (GO:0010257)3.94896069
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94896069
9protein complex biogenesis (GO:0070271)3.91709282
10respiratory chain complex IV assembly (GO:0008535)3.90590600
11chaperone-mediated protein transport (GO:0072321)3.74542097
12regulation of centriole replication (GO:0046599)3.63967874
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62270249
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62270249
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59490340
16mitochondrial respiratory chain complex assembly (GO:0033108)3.57922514
17platelet dense granule organization (GO:0060155)3.56440480
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47772537
19maturation of 5.8S rRNA (GO:0000460)3.39151368
20ubiquinone biosynthetic process (GO:0006744)3.35621636
21cytochrome complex assembly (GO:0017004)3.34493033
22pseudouridine synthesis (GO:0001522)3.30095196
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.25933574
24termination of RNA polymerase III transcription (GO:0006386)3.25933574
25proteasome assembly (GO:0043248)3.22838960
26somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.22219502
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.22219502
28isotype switching (GO:0045190)3.22219502
29nonmotile primary cilium assembly (GO:0035058)3.21876747
30ncRNA catabolic process (GO:0034661)3.19966786
31ubiquinone metabolic process (GO:0006743)3.17158034
32intraciliary transport (GO:0042073)3.15093056
33tryptophan metabolic process (GO:0006568)3.12848083
34rRNA catabolic process (GO:0016075)3.10767008
35tRNA processing (GO:0008033)3.10648077
36RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06521148
37replication fork processing (GO:0031297)3.04993263
38histone mRNA metabolic process (GO:0008334)3.00825147
39negative regulation of DNA recombination (GO:0045910)3.00046851
40regulation of helicase activity (GO:0051095)2.98423991
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96176583
42positive regulation of mitochondrial fission (GO:0090141)2.94733810
43indolalkylamine metabolic process (GO:0006586)2.92647820
44mannosylation (GO:0097502)2.92410634
45lysine catabolic process (GO:0006554)2.90145156
46lysine metabolic process (GO:0006553)2.90145156
47piRNA metabolic process (GO:0034587)2.88134823
48indole-containing compound catabolic process (GO:0042436)2.87435901
49indolalkylamine catabolic process (GO:0046218)2.87435901
50tryptophan catabolic process (GO:0006569)2.87435901
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.86429997
52protein deneddylation (GO:0000338)2.84242673
53regulation of nuclear cell cycle DNA replication (GO:0033262)2.83171709
54DNA catabolic process, exonucleolytic (GO:0000738)2.82646551
55somite rostral/caudal axis specification (GO:0032525)2.81065556
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.80098813
57branched-chain amino acid catabolic process (GO:0009083)2.78726225
58regulation of cilium movement (GO:0003352)2.77549377
59reciprocal DNA recombination (GO:0035825)2.77363525
60reciprocal meiotic recombination (GO:0007131)2.77363525
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.74785109
62energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74275459
63ATP synthesis coupled proton transport (GO:0015986)2.74275459
64tRNA metabolic process (GO:0006399)2.72410630
65neural tube formation (GO:0001841)2.72409904
66negative regulation of telomere maintenance (GO:0032205)2.71131204
67transcription elongation from RNA polymerase I promoter (GO:0006362)2.71040463
68phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70994493
69inositol phosphate dephosphorylation (GO:0046855)2.70994493
70non-recombinational repair (GO:0000726)2.70963065
71double-strand break repair via nonhomologous end joining (GO:0006303)2.70963065
72response to pheromone (GO:0019236)2.69985624
73single strand break repair (GO:0000012)2.67848257
74preassembly of GPI anchor in ER membrane (GO:0016254)2.65760039
75polyol catabolic process (GO:0046174)2.64789868
76aldehyde catabolic process (GO:0046185)2.64554927
77protein K6-linked ubiquitination (GO:0085020)2.63107531
78kynurenine metabolic process (GO:0070189)2.60960758
79chromatin remodeling at centromere (GO:0031055)2.59159973
80fucose catabolic process (GO:0019317)2.58953422
81L-fucose metabolic process (GO:0042354)2.58953422
82L-fucose catabolic process (GO:0042355)2.58953422
83S-adenosylmethionine metabolic process (GO:0046500)2.58368720
84behavioral response to nicotine (GO:0035095)2.56817409
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56632001
86DNA deamination (GO:0045006)2.56420616
87termination of RNA polymerase I transcription (GO:0006363)2.55956960
88resolution of meiotic recombination intermediates (GO:0000712)2.55468503
89photoreceptor cell maintenance (GO:0045494)2.55247893
90signal peptide processing (GO:0006465)2.54825494
91cellular ketone body metabolic process (GO:0046950)2.54651144
92inositol phosphate catabolic process (GO:0071545)2.54493966
93transcription from RNA polymerase III promoter (GO:0006383)2.53844043
94rRNA modification (GO:0000154)2.53157314
95histone mRNA catabolic process (GO:0071044)2.52985629
96synapsis (GO:0007129)2.52663733
97anterograde synaptic vesicle transport (GO:0048490)2.52362311
98GPI anchor metabolic process (GO:0006505)2.51708742
99gamma-aminobutyric acid transport (GO:0015812)2.51622288
100recombinational repair (GO:0000725)2.51217761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54338361
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.46700091
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38649052
4VDR_22108803_ChIP-Seq_LS180_Human2.96833346
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91238294
6* EST1_17652178_ChIP-ChIP_JURKAT_Human2.89836208
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.83784658
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78908387
9ELK1_19687146_ChIP-ChIP_HELA_Human2.69736030
10IGF1R_20145208_ChIP-Seq_DFB_Human2.61831089
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.60544663
12FUS_26573619_Chip-Seq_HEK293_Human2.51594318
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40844314
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40198051
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35873661
16EWS_26573619_Chip-Seq_HEK293_Human2.12682371
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06641075
18GBX2_23144817_ChIP-Seq_PC3_Human2.06376449
19P300_19829295_ChIP-Seq_ESCs_Human2.04663224
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04645113
21VDR_23849224_ChIP-Seq_CD4+_Human1.98509543
22TAF15_26573619_Chip-Seq_HEK293_Human1.96109963
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.92496723
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89702399
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83936725
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82254946
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.81110613
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78319904
29MYC_18940864_ChIP-ChIP_HL60_Human1.70841551
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70029749
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69998274
32* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69733483
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.68479131
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68430970
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60319715
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57648393
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56866756
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53869175
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.52864915
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51546506
41IRF1_19129219_ChIP-ChIP_H3396_Human1.50873224
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49254913
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45245004
44CBP_20019798_ChIP-Seq_JUKART_Human1.45245004
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38675255
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37651250
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.36736045
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35502220
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34342994
50ER_23166858_ChIP-Seq_MCF-7_Human1.33918327
51NANOG_19829295_ChIP-Seq_ESCs_Human1.30668377
52SOX2_19829295_ChIP-Seq_ESCs_Human1.30668377
53TP53_22573176_ChIP-Seq_HFKS_Human1.26054276
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24743385
55* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24600820
56SMAD4_21799915_ChIP-Seq_A2780_Human1.22900007
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18582472
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.18222629
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.15869099
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15728637
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14773738
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14693470
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13538208
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.13538208
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11892366
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.10460226
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09819689
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.09783996
69AR_25329375_ChIP-Seq_VCAP_Human1.09710249
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09678458
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09431080
72* SOX2_16153702_ChIP-ChIP_HESCs_Human1.09283661
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09266045
74AR_20517297_ChIP-Seq_VCAP_Human1.06957831
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06631022
76GABP_19822575_ChIP-Seq_HepG2_Human1.06237676
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05381666
78STAT3_23295773_ChIP-Seq_U87_Human1.05150496
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04368787
80CDX2_22108803_ChIP-Seq_LS180_Human1.03044564
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02031185
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.01411549
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01190656
84P300_18555785_Chip-Seq_ESCs_Mouse1.00866690
85TCF4_22108803_ChIP-Seq_LS180_Human1.00411567
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.00383924
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00046324
88RUNX2_22187159_ChIP-Seq_PCA_Human0.99925179
89TCF4_23295773_ChIP-Seq_U87_Human0.99454970
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98542588
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.98482565
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97875602
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97664547
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97450859
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96876663
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96548981
97BCAT_22108803_ChIP-Seq_LS180_Human0.94886529
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94619780
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94619780
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.93741053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.11694083
2MP0003787_abnormal_imprinting2.94753942
3MP0008058_abnormal_DNA_repair2.81365908
4MP0002102_abnormal_ear_morphology2.57384878
5MP0005084_abnormal_gallbladder_morpholo2.48965920
6MP0008789_abnormal_olfactory_epithelium2.40405408
7MP0005645_abnormal_hypothalamus_physiol2.33170466
8MP0002822_catalepsy2.29777796
9MP0002837_dystrophic_cardiac_calcinosis2.17908543
10MP0000569_abnormal_digit_pigmentation2.16479129
11MP0003880_abnormal_central_pattern2.12396988
12MP0001529_abnormal_vocalization2.06174953
13MP0003195_calcinosis2.01788430
14MP0006292_abnormal_olfactory_placode2.00410739
15MP0005499_abnormal_olfactory_system1.85607061
16MP0005394_taste/olfaction_phenotype1.85607061
17MP0006072_abnormal_retinal_apoptosis1.75992494
18MP0003567_abnormal_fetal_cardiomyocyte1.71608731
19MP0000516_abnormal_urinary_system1.69015947
20MP0005367_renal/urinary_system_phenotyp1.69015947
21MP0001764_abnormal_homeostasis1.68469477
22MP0000372_irregular_coat_pigmentation1.68419961
23MP0005646_abnormal_pituitary_gland1.64504259
24MP0002938_white_spotting1.63084664
25MP0002163_abnormal_gland_morphology1.60719920
26MP0002638_abnormal_pupillary_reflex1.57551460
27MP0005551_abnormal_eye_electrophysiolog1.57152005
28MP0003121_genomic_imprinting1.57125806
29MP0010094_abnormal_chromosome_stability1.55105860
30MP0003693_abnormal_embryo_hatching1.53354826
31MP0002277_abnormal_respiratory_mucosa1.53023986
32MP0005174_abnormal_tail_pigmentation1.53004672
33MP0003718_maternal_effect1.49483450
34MP0004142_abnormal_muscle_tone1.45427416
35MP0003186_abnormal_redox_activity1.43145240
36MP0002751_abnormal_autonomic_nervous1.42542670
37MP0005253_abnormal_eye_physiology1.39929900
38MP0001984_abnormal_olfaction1.36637696
39MP0003890_abnormal_embryonic-extraembry1.35396626
40MP0004215_abnormal_myocardial_fiber1.34937600
41MP0003011_delayed_dark_adaptation1.33882630
42MP0000631_abnormal_neuroendocrine_gland1.32505819
43MP0000427_abnormal_hair_cycle1.31544820
44MP0005075_abnormal_melanosome_morpholog1.31063661
45MP0002736_abnormal_nociception_after1.31043820
46MP0001929_abnormal_gametogenesis1.30460296
47MP0001188_hyperpigmentation1.29598864
48MP0006276_abnormal_autonomic_nervous1.29085858
49MP0001293_anophthalmia1.28085604
50MP0005410_abnormal_fertilization1.26374695
51MP0009046_muscle_twitch1.25697124
52MP0004147_increased_porphyrin_level1.24765367
53MP0002138_abnormal_hepatobiliary_system1.23965212
54MP0003646_muscle_fatigue1.23290671
55MP0005379_endocrine/exocrine_gland_phen1.23103987
56MP0009697_abnormal_copulation1.22731426
57MP0004957_abnormal_blastocyst_morpholog1.21625582
58MP0002653_abnormal_ependyma_morphology1.20795056
59MP0008007_abnormal_cellular_replicative1.19794189
60MP0005220_abnormal_exocrine_pancreas1.18280418
61MP0004133_heterotaxia1.17724159
62MP0003122_maternal_imprinting1.15898843
63MP0001324_abnormal_eye_pigmentation1.15113998
64MP0006036_abnormal_mitochondrial_physio1.14201995
65MP0003786_premature_aging1.13626663
66MP0006054_spinal_hemorrhage1.10820341
67MP0002095_abnormal_skin_pigmentation1.08051132
68MP0003698_abnormal_male_reproductive1.07493264
69MP0002233_abnormal_nose_morphology1.07452346
70MP0001485_abnormal_pinna_reflex1.06987910
71MP0003315_abnormal_perineum_morphology1.06634804
72MP0003111_abnormal_nucleus_morphology1.02430955
73MP0003077_abnormal_cell_cycle1.00824529
74MP0002234_abnormal_pharynx_morphology1.00823773
75MP0008995_early_reproductive_senescence0.97521861
76MP0001968_abnormal_touch/_nociception0.96580971
77MP0008932_abnormal_embryonic_tissue0.95548659
78MP0002735_abnormal_chemical_nociception0.95418688
79MP0004043_abnormal_pH_regulation0.94015455
80MP0002210_abnormal_sex_determination0.93941589
81MP0006035_abnormal_mitochondrial_morpho0.92327288
82MP0000613_abnormal_salivary_gland0.90401710
83MP0003937_abnormal_limbs/digits/tail_de0.90015714
84MP0001145_abnormal_male_reproductive0.88569819
85MP0003136_yellow_coat_color0.87656008
86MP0008872_abnormal_physiological_respon0.87142863
87MP0000653_abnormal_sex_gland0.87023962
88MP0009745_abnormal_behavioral_response0.86719780
89MP0001119_abnormal_female_reproductive0.86551791
90MP0002160_abnormal_reproductive_system0.81490080
91MP0003806_abnormal_nucleotide_metabolis0.79951953
92MP0001486_abnormal_startle_reflex0.79770372
93MP0002557_abnormal_social/conspecific_i0.79511129
94MP0005389_reproductive_system_phenotype0.77681569
95MP0001919_abnormal_reproductive_system0.77393178
96MP0001286_abnormal_eye_development0.77337161
97MP0002928_abnormal_bile_duct0.76805946
98MP0002272_abnormal_nervous_system0.75998620
99MP0000778_abnormal_nervous_system0.75546893
100MP0000371_diluted_coat_color0.75270015

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.19575378
2Abnormality of midbrain morphology (HP:0002418)3.13824642
3Molar tooth sign on MRI (HP:0002419)3.13824642
4Pancreatic cysts (HP:0001737)3.09014497
5Medial flaring of the eyebrow (HP:0010747)3.06304177
6Acute necrotizing encephalopathy (HP:0006965)3.03354607
7Methylmalonic acidemia (HP:0002912)2.95765122
8Mitochondrial inheritance (HP:0001427)2.85964793
9Congenital primary aphakia (HP:0007707)2.80900370
10Renal cortical cysts (HP:0000803)2.76702711
11Gait imbalance (HP:0002141)2.75453879
12Increased CSF lactate (HP:0002490)2.72671842
13Acute encephalopathy (HP:0006846)2.71305944
14Intestinal atresia (HP:0011100)2.69710555
15Colon cancer (HP:0003003)2.66929936
16Pendular nystagmus (HP:0012043)2.66834739
17Congenital stationary night blindness (HP:0007642)2.65980661
18Nephrogenic diabetes insipidus (HP:0009806)2.63499587
19Abolished electroretinogram (ERG) (HP:0000550)2.63166233
20Abnormal mitochondria in muscle tissue (HP:0008316)2.62772964
21Nephronophthisis (HP:0000090)2.62377289
22True hermaphroditism (HP:0010459)2.62224805
23Type I transferrin isoform profile (HP:0003642)2.61313242
24Hepatocellular necrosis (HP:0001404)2.56764571
25Abnormality of the labia minora (HP:0012880)2.55844739
26Progressive macrocephaly (HP:0004481)2.54091779
27Chronic hepatic failure (HP:0100626)2.50695125
28Genital tract atresia (HP:0001827)2.48721898
29Abnormality of the renal cortex (HP:0011035)2.43697969
30Vaginal atresia (HP:0000148)2.43184177
31Increased hepatocellular lipid droplets (HP:0006565)2.40620285
32Lipid accumulation in hepatocytes (HP:0006561)2.39186855
33Volvulus (HP:0002580)2.36641258
34Hepatic necrosis (HP:0002605)2.35190016
35Abnormal rod and cone electroretinograms (HP:0008323)2.34357141
36Hyperglycinemia (HP:0002154)2.29492777
37Abnormality of the renal medulla (HP:0100957)2.28740926
38Inability to walk (HP:0002540)2.26323369
39Stomatitis (HP:0010280)2.24130676
40Hyperventilation (HP:0002883)2.23468150
41Attenuation of retinal blood vessels (HP:0007843)2.23347703
42Optic nerve hypoplasia (HP:0000609)2.19681264
43Abnormality of macular pigmentation (HP:0008002)2.18441115
443-Methylglutaconic aciduria (HP:0003535)2.17209626
45Increased serum lactate (HP:0002151)2.16963037
46Bifid tongue (HP:0010297)2.16544702
47Progressive inability to walk (HP:0002505)2.16483880
48Methylmalonic aciduria (HP:0012120)2.15746794
49Abnormal protein N-linked glycosylation (HP:0012347)2.14738279
50Abnormal protein glycosylation (HP:0012346)2.14738279
51Abnormal glycosylation (HP:0012345)2.14738279
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14738279
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13487939
54Renal Fanconi syndrome (HP:0001994)2.13388318
55Pancreatic islet-cell hyperplasia (HP:0004510)2.10510197
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09283199
57Postaxial hand polydactyly (HP:0001162)2.08077809
58Tubulointerstitial nephritis (HP:0001970)2.07336396
59Abnormality of methionine metabolism (HP:0010901)2.06065075
60Severe visual impairment (HP:0001141)2.06011883
61Hyperglycinuria (HP:0003108)2.04959464
62Septo-optic dysplasia (HP:0100842)2.03812269
63Stenosis of the external auditory canal (HP:0000402)2.02909058
64Cerebral edema (HP:0002181)2.00327854
65Large for gestational age (HP:0001520)1.99314975
66Postaxial foot polydactyly (HP:0001830)1.97581480
67Anencephaly (HP:0002323)1.94380042
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92583385
69Rhabdomyosarcoma (HP:0002859)1.91877891
70Gonadotropin excess (HP:0000837)1.88407478
71Lactic acidosis (HP:0003128)1.86542918
72Hypoplastic pelvis (HP:0008839)1.86204941
73Neoplasm of the adrenal cortex (HP:0100641)1.86078556
74Poor coordination (HP:0002370)1.84940457
75Optic disc pallor (HP:0000543)1.84737968
76Congenital hepatic fibrosis (HP:0002612)1.84604591
77Abnormality of serine family amino acid metabolism (HP:0010894)1.81013587
78Abnormality of glycine metabolism (HP:0010895)1.81013587
79Median cleft lip (HP:0000161)1.79284049
80Oligodactyly (hands) (HP:0001180)1.77695477
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.75315577
82Gaze-evoked nystagmus (HP:0000640)1.75314836
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.74641474
84Sclerocornea (HP:0000647)1.73862751
85Abnormality of vitamin B metabolism (HP:0004340)1.73635966
86Type II lissencephaly (HP:0007260)1.73059313
87Aplasia/hypoplasia of the uterus (HP:0008684)1.72603081
88Thyroid-stimulating hormone excess (HP:0002925)1.70825919
89Curly hair (HP:0002212)1.68497276
90Lethargy (HP:0001254)1.67868788
91Cutaneous melanoma (HP:0012056)1.67825425
92Lissencephaly (HP:0001339)1.67791952
93Decreased testicular size (HP:0008734)1.67369263
94Albinism (HP:0001022)1.67351845
95Abnormality of chromosome stability (HP:0003220)1.64317644
96Respiratory failure (HP:0002878)1.64191007
97Hepatoblastoma (HP:0002884)1.63971689
98Hypothermia (HP:0002045)1.63455081
99Cellular immunodeficiency (HP:0005374)1.61664243
100Ketoacidosis (HP:0001993)1.59847182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.46094701
2WNK33.25350265
3CDK192.91003464
4MAP4K22.74688172
5TNIK2.71475759
6NUAK12.63636552
7BCR2.37677767
8MAP3K42.10175751
9TRIM282.08878177
10ACVR1B2.06418259
11EIF2AK32.00486273
12BMPR1B1.93920712
13GRK11.90043353
14MKNK21.89644654
15STK38L1.87777933
16OXSR11.79200933
17ZAK1.76579996
18ADRBK21.75762463
19CASK1.69028548
20STK161.58626306
21PINK11.43845461
22PLK31.40708823
23ERBB31.36288849
24MAPK131.35638031
25BCKDK1.34264906
26MST41.32955588
27MKNK11.32106304
28BRSK21.29047590
29STK391.27574523
30TAOK31.25672993
31MAP2K71.25342023
32WNK41.23674526
33INSRR1.23219996
34TAF11.22923048
35NLK1.20843302
36CSNK1G11.18811759
37NEK11.18148977
38TSSK61.17426599
39PLK41.15016849
40PLK21.11993211
41VRK11.10673803
42SRPK11.09608859
43DYRK21.08209192
44CAMK1D1.07819211
45DYRK31.07533515
46TXK1.04897638
47AKT31.01678514
48CSNK1G30.93246692
49BUB10.89477494
50CSNK1G20.84604828
51CAMK1G0.83395726
52PRKCG0.83328428
53PRKCE0.81980631
54CSNK1A1L0.81465735
55PLK10.76936271
56FLT30.76321554
57PAK30.76100305
58TTK0.73745527
59ATR0.72126199
60TLK10.69638830
61ATM0.66763491
62STK30.65643297
63MAP2K60.64840098
64CDC70.61747970
65TEC0.60273831
66CHEK20.54659561
67PRKD30.52445303
68CAMKK20.50423328
69KIT0.45063003
70PASK0.45036084
71DYRK1A0.43597537
72PBK0.43462175
73CSNK2A20.43321910
74VRK20.43201702
75PRKCI0.43021280
76AURKB0.41529909
77SGK20.41338618
78PRKCZ0.40284650
79FER0.39370344
80OBSCN0.39228127
81GRK70.37929261
82TGFBR10.36657934
83PRKCQ0.36239483
84RPS6KA50.36024290
85PRKDC0.35952071
86CSNK1A10.35869237
87CSNK2A10.35358457
88CHEK10.35198419
89PRKACA0.34212090
90EPHA30.33137257
91TNK20.32447710
92EGFR0.32432076
93DAPK10.32012806
94ADRBK10.31825837
95STK110.31386912
96FGFR20.30411136
97MAP2K40.29652344
98ERBB40.29055613
99PNCK0.28996370
100LIMK10.28975616

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.49286236
2Non-homologous end-joining_Homo sapiens_hsa034502.99675961
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78674947
4RNA polymerase_Homo sapiens_hsa030202.77364335
5Proteasome_Homo sapiens_hsa030502.72789539
6Propanoate metabolism_Homo sapiens_hsa006402.58292355
7Basal transcription factors_Homo sapiens_hsa030222.58061093
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53982000
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42380976
10Oxidative phosphorylation_Homo sapiens_hsa001902.36927934
11Butanoate metabolism_Homo sapiens_hsa006502.35317525
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31694442
13Parkinsons disease_Homo sapiens_hsa050122.07367246
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02426154
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00132577
16Homologous recombination_Homo sapiens_hsa034401.96336464
17RNA degradation_Homo sapiens_hsa030181.86061115
18Fatty acid elongation_Homo sapiens_hsa000621.84960169
19Peroxisome_Homo sapiens_hsa041461.83961530
20Steroid biosynthesis_Homo sapiens_hsa001001.78054771
21Selenocompound metabolism_Homo sapiens_hsa004501.75595785
22Tryptophan metabolism_Homo sapiens_hsa003801.71586937
23Fanconi anemia pathway_Homo sapiens_hsa034601.69063969
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59651435
25Phototransduction_Homo sapiens_hsa047441.58631434
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54174913
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.45728662
28Huntingtons disease_Homo sapiens_hsa050161.42299353
29RNA transport_Homo sapiens_hsa030131.40339593
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39679871
31Fatty acid metabolism_Homo sapiens_hsa012121.38186199
32Fatty acid degradation_Homo sapiens_hsa000711.29161027
33Mismatch repair_Homo sapiens_hsa034301.25328712
34Nucleotide excision repair_Homo sapiens_hsa034201.24708059
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20382243
36Nitrogen metabolism_Homo sapiens_hsa009101.17424891
37beta-Alanine metabolism_Homo sapiens_hsa004101.16724136
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16359441
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13422882
40Pyrimidine metabolism_Homo sapiens_hsa002401.11178779
41Ribosome_Homo sapiens_hsa030101.07107904
42Alzheimers disease_Homo sapiens_hsa050101.06563945
43Purine metabolism_Homo sapiens_hsa002301.04285348
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97988897
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96537895
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.96430976
47Spliceosome_Homo sapiens_hsa030400.96315131
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95155466
49Linoleic acid metabolism_Homo sapiens_hsa005910.93814857
50Taste transduction_Homo sapiens_hsa047420.93086172
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92333150
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91625659
53One carbon pool by folate_Homo sapiens_hsa006700.88437992
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.85796098
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84810159
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84482604
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82654700
58Base excision repair_Homo sapiens_hsa034100.80888791
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78812416
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78704709
61Olfactory transduction_Homo sapiens_hsa047400.77997866
62Regulation of autophagy_Homo sapiens_hsa041400.77457912
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75075145
64Chemical carcinogenesis_Homo sapiens_hsa052040.74815696
65Metabolic pathways_Homo sapiens_hsa011000.72658853
66Sulfur relay system_Homo sapiens_hsa041220.71116997
67Pyruvate metabolism_Homo sapiens_hsa006200.70700148
68Vitamin B6 metabolism_Homo sapiens_hsa007500.70162310
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70036008
70Ether lipid metabolism_Homo sapiens_hsa005650.69130753
71DNA replication_Homo sapiens_hsa030300.68865135
72Nicotine addiction_Homo sapiens_hsa050330.68860678
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68399775
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66364555
75Collecting duct acid secretion_Homo sapiens_hsa049660.65279915
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64709954
77Cardiac muscle contraction_Homo sapiens_hsa042600.57239442
78Retinol metabolism_Homo sapiens_hsa008300.57166694
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.55607935
80Fatty acid biosynthesis_Homo sapiens_hsa000610.52503875
81Glutathione metabolism_Homo sapiens_hsa004800.50809403
82Caffeine metabolism_Homo sapiens_hsa002320.45690594
83Vitamin digestion and absorption_Homo sapiens_hsa049770.43307377
84Primary immunodeficiency_Homo sapiens_hsa053400.41312322
85Asthma_Homo sapiens_hsa053100.40126921
86Cell cycle_Homo sapiens_hsa041100.35250255
87Type I diabetes mellitus_Homo sapiens_hsa049400.32997323
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31809862
89Carbon metabolism_Homo sapiens_hsa012000.30353186
90p53 signaling pathway_Homo sapiens_hsa041150.28558958
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28401719
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27439904
93Fat digestion and absorption_Homo sapiens_hsa049750.27416697
94Renin-angiotensin system_Homo sapiens_hsa046140.22366688
95Arachidonic acid metabolism_Homo sapiens_hsa005900.21483897
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20759286
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17619820
98Sulfur metabolism_Homo sapiens_hsa009200.17410804
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16014570
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.15754954

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