ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.39088456
2	DNA double-strand break processing (GO:0000729)	4.37499562
3	regulation of mitotic spindle checkpoint (GO:1903504)	3.97162388
4	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.97162388
5	protein-cofactor linkage (GO:0018065)	3.96360618
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94896069
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94896069
8	NADH dehydrogenase complex assembly (GO:0010257)	3.94896069
9	protein complex biogenesis (GO:0070271)	3.91709282
10	respiratory chain complex IV assembly (GO:0008535)	3.90590600
11	chaperone-mediated protein transport (GO:0072321)	3.74542097
12	regulation of centriole replication (GO:0046599)	3.63967874
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.62270249
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.62270249
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.59490340
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.57922514
17	platelet dense granule organization (GO:0060155)	3.56440480
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.47772537
19	maturation of 5.8S rRNA (GO:0000460)	3.39151368
20	ubiquinone biosynthetic process (GO:0006744)	3.35621636
21	cytochrome complex assembly (GO:0017004)	3.34493033
22	pseudouridine synthesis (GO:0001522)	3.30095196
23	termination of RNA polymerase III transcription (GO:0006386)	3.25933574
24	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.25933574
25	proteasome assembly (GO:0043248)	3.22838960
26	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.22219502
27	isotype switching (GO:0045190)	3.22219502
28	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.22219502
29	nonmotile primary cilium assembly (GO:0035058)	3.21876747
30	ncRNA catabolic process (GO:0034661)	3.19966786
31	ubiquinone metabolic process (GO:0006743)	3.17158034
32	intraciliary transport (GO:0042073)	3.15093056
33	tryptophan metabolic process (GO:0006568)	3.12848083
34	rRNA catabolic process (GO:0016075)	3.10767008
35	tRNA processing (GO:0008033)	3.10648077
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.06521148
37	replication fork processing (GO:0031297)	3.04993263
38	histone mRNA metabolic process (GO:0008334)	3.00825147
39	negative regulation of DNA recombination (GO:0045910)	3.00046851
40	regulation of helicase activity (GO:0051095)	2.98423991
41	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.96176583
42	positive regulation of mitochondrial fission (GO:0090141)	2.94733810
43	indolalkylamine metabolic process (GO:0006586)	2.92647820
44	mannosylation (GO:0097502)	2.92410634
45	lysine metabolic process (GO:0006553)	2.90145156
46	lysine catabolic process (GO:0006554)	2.90145156
47	piRNA metabolic process (GO:0034587)	2.88134823
48	tryptophan catabolic process (GO:0006569)	2.87435901
49	indole-containing compound catabolic process (GO:0042436)	2.87435901
50	indolalkylamine catabolic process (GO:0046218)	2.87435901
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.86429997
52	protein deneddylation (GO:0000338)	2.84242673
53	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83171709
54	DNA catabolic process, exonucleolytic (GO:0000738)	2.82646551
55	somite rostral/caudal axis specification (GO:0032525)	2.81065556
56	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.80098813
57	branched-chain amino acid catabolic process (GO:0009083)	2.78726225
58	regulation of cilium movement (GO:0003352)	2.77549377
59	reciprocal meiotic recombination (GO:0007131)	2.77363525
60	reciprocal DNA recombination (GO:0035825)	2.77363525
61	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.74785109
62	ATP synthesis coupled proton transport (GO:0015986)	2.74275459
63	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74275459
64	tRNA metabolic process (GO:0006399)	2.72410630
65	neural tube formation (GO:0001841)	2.72409904
66	negative regulation of telomere maintenance (GO:0032205)	2.71131204
67	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.71040463
68	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.70994493
69	inositol phosphate dephosphorylation (GO:0046855)	2.70994493
70	double-strand break repair via nonhomologous end joining (GO:0006303)	2.70963065
71	non-recombinational repair (GO:0000726)	2.70963065
72	response to pheromone (GO:0019236)	2.69985624
73	single strand break repair (GO:0000012)	2.67848257
74	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65760039
75	polyol catabolic process (GO:0046174)	2.64789868
76	aldehyde catabolic process (GO:0046185)	2.64554927
77	protein K6-linked ubiquitination (GO:0085020)	2.63107531
78	kynurenine metabolic process (GO:0070189)	2.60960758
79	chromatin remodeling at centromere (GO:0031055)	2.59159973
80	L-fucose catabolic process (GO:0042355)	2.58953422
81	fucose catabolic process (GO:0019317)	2.58953422
82	L-fucose metabolic process (GO:0042354)	2.58953422
83	S-adenosylmethionine metabolic process (GO:0046500)	2.58368720
84	behavioral response to nicotine (GO:0035095)	2.56817409
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.56632001
86	DNA deamination (GO:0045006)	2.56420616
87	termination of RNA polymerase I transcription (GO:0006363)	2.55956960
88	resolution of meiotic recombination intermediates (GO:0000712)	2.55468503
89	photoreceptor cell maintenance (GO:0045494)	2.55247893
90	signal peptide processing (GO:0006465)	2.54825494
91	cellular ketone body metabolic process (GO:0046950)	2.54651144
92	inositol phosphate catabolic process (GO:0071545)	2.54493966
93	transcription from RNA polymerase III promoter (GO:0006383)	2.53844043
94	rRNA modification (GO:0000154)	2.53157314
95	histone mRNA catabolic process (GO:0071044)	2.52985629
96	synapsis (GO:0007129)	2.52663733
97	anterograde synaptic vesicle transport (GO:0048490)	2.52362311
98	GPI anchor metabolic process (GO:0006505)	2.51708742
99	gamma-aminobutyric acid transport (GO:0015812)	2.51622288
100	recombinational repair (GO:0000725)	2.51217761

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.54338361
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.46700091
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.38649052
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96833346
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91238294
6	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89836208
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.83784658
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78908387
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.69736030
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61831089
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.60544663
12	FUS_26573619_Chip-Seq_HEK293_Human	2.51594318
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40844314
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.40198051
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35873661
16	EWS_26573619_Chip-Seq_HEK293_Human	2.12682371
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06641075
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.06376449
19	P300_19829295_ChIP-Seq_ESCs_Human	2.04663224
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04645113
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.98509543
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.96109963
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92496723
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89702399
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83936725
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82254946
27	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81110613
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.78319904
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.70841551
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.70029749
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69998274
32	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.69733483
33	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.68479131
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.68430970
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60319715
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57648393
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56866756
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53869175
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52864915
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51546506
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50873224
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49254913
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45245004
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.45245004
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38675255
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37651250
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36736045
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35502220
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34342994
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.33918327
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30668377
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30668377
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.26054276
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24743385
55	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24600820
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22900007
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18582472
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18222629
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15869099
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15728637
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14773738
62	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.14693470
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13538208
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13538208
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11892366
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10460226
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09819689
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09783996
69	AR_25329375_ChIP-Seq_VCAP_Human	1.09710249
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09678458
71	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09431080
72	* SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09283661
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.09266045
74	AR_20517297_ChIP-Seq_VCAP_Human	1.06957831
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06631022
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.06237676
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05381666
78	STAT3_23295773_ChIP-Seq_U87_Human	1.05150496
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04368787
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.03044564
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02031185
82	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01411549
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01190656
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.00866690
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.00411567
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00383924
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00046324
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99925179
89	TCF4_23295773_ChIP-Seq_U87_Human	0.99454970
90	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.98542588
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98482565
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97875602
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97664547
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97450859
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96876663
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96548981
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.94886529
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94619780
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94619780
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93741053

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.11694083
2	MP0003787_abnormal_imprinting	2.94753942
3	MP0008058_abnormal_DNA_repair	2.81365908
4	MP0002102_abnormal_ear_morphology	2.57384878
5	MP0005084_abnormal_gallbladder_morpholo	2.48965920
6	MP0008789_abnormal_olfactory_epithelium	2.40405408
7	MP0005645_abnormal_hypothalamus_physiol	2.33170466
8	MP0002822_catalepsy	2.29777796
9	MP0002837_dystrophic_cardiac_calcinosis	2.17908543
10	MP0000569_abnormal_digit_pigmentation	2.16479129
11	MP0003880_abnormal_central_pattern	2.12396988
12	MP0001529_abnormal_vocalization	2.06174953
13	MP0003195_calcinosis	2.01788430
14	MP0006292_abnormal_olfactory_placode	2.00410739
15	MP0005499_abnormal_olfactory_system	1.85607061
16	MP0005394_taste/olfaction_phenotype	1.85607061
17	MP0006072_abnormal_retinal_apoptosis	1.75992494
18	MP0003567_abnormal_fetal_cardiomyocyte	1.71608731
19	MP0005367_renal/urinary_system_phenotyp	1.69015947
20	MP0000516_abnormal_urinary_system	1.69015947
21	MP0001764_abnormal_homeostasis	1.68469477
22	MP0000372_irregular_coat_pigmentation	1.68419961
23	MP0005646_abnormal_pituitary_gland	1.64504259
24	MP0002938_white_spotting	1.63084664
25	MP0002163_abnormal_gland_morphology	1.60719920
26	MP0002638_abnormal_pupillary_reflex	1.57551460
27	MP0005551_abnormal_eye_electrophysiolog	1.57152005
28	MP0003121_genomic_imprinting	1.57125806
29	MP0010094_abnormal_chromosome_stability	1.55105860
30	MP0003693_abnormal_embryo_hatching	1.53354826
31	MP0002277_abnormal_respiratory_mucosa	1.53023986
32	MP0005174_abnormal_tail_pigmentation	1.53004672
33	MP0003718_maternal_effect	1.49483450
34	MP0004142_abnormal_muscle_tone	1.45427416
35	MP0003186_abnormal_redox_activity	1.43145240
36	MP0002751_abnormal_autonomic_nervous	1.42542670
37	MP0005253_abnormal_eye_physiology	1.39929900
38	MP0001984_abnormal_olfaction	1.36637696
39	MP0003890_abnormal_embryonic-extraembry	1.35396626
40	MP0004215_abnormal_myocardial_fiber	1.34937600
41	MP0003011_delayed_dark_adaptation	1.33882630
42	MP0000631_abnormal_neuroendocrine_gland	1.32505819
43	MP0000427_abnormal_hair_cycle	1.31544820
44	MP0005075_abnormal_melanosome_morpholog	1.31063661
45	MP0002736_abnormal_nociception_after	1.31043820
46	MP0001929_abnormal_gametogenesis	1.30460296
47	MP0001188_hyperpigmentation	1.29598864
48	MP0006276_abnormal_autonomic_nervous	1.29085858
49	MP0001293_anophthalmia	1.28085604
50	MP0005410_abnormal_fertilization	1.26374695
51	MP0009046_muscle_twitch	1.25697124
52	MP0004147_increased_porphyrin_level	1.24765367
53	MP0002138_abnormal_hepatobiliary_system	1.23965212
54	MP0003646_muscle_fatigue	1.23290671
55	MP0005379_endocrine/exocrine_gland_phen	1.23103987
56	MP0009697_abnormal_copulation	1.22731426
57	MP0004957_abnormal_blastocyst_morpholog	1.21625582
58	MP0002653_abnormal_ependyma_morphology	1.20795056
59	MP0008007_abnormal_cellular_replicative	1.19794189
60	MP0005220_abnormal_exocrine_pancreas	1.18280418
61	MP0004133_heterotaxia	1.17724159
62	MP0003122_maternal_imprinting	1.15898843
63	MP0001324_abnormal_eye_pigmentation	1.15113998
64	MP0006036_abnormal_mitochondrial_physio	1.14201995
65	MP0003786_premature_aging	1.13626663
66	MP0006054_spinal_hemorrhage	1.10820341
67	MP0002095_abnormal_skin_pigmentation	1.08051132
68	MP0003698_abnormal_male_reproductive	1.07493264
69	MP0002233_abnormal_nose_morphology	1.07452346
70	MP0001485_abnormal_pinna_reflex	1.06987910
71	MP0003315_abnormal_perineum_morphology	1.06634804
72	MP0003111_abnormal_nucleus_morphology	1.02430955
73	MP0003077_abnormal_cell_cycle	1.00824529
74	MP0002234_abnormal_pharynx_morphology	1.00823773
75	MP0008995_early_reproductive_senescence	0.97521861
76	MP0001968_abnormal_touch/_nociception	0.96580971
77	MP0008932_abnormal_embryonic_tissue	0.95548659
78	MP0002735_abnormal_chemical_nociception	0.95418688
79	MP0004043_abnormal_pH_regulation	0.94015455
80	MP0002210_abnormal_sex_determination	0.93941589
81	MP0006035_abnormal_mitochondrial_morpho	0.92327288
82	MP0000613_abnormal_salivary_gland	0.90401710
83	MP0003937_abnormal_limbs/digits/tail_de	0.90015714
84	MP0001145_abnormal_male_reproductive	0.88569819
85	MP0003136_yellow_coat_color	0.87656008
86	MP0008872_abnormal_physiological_respon	0.87142863
87	MP0000653_abnormal_sex_gland	0.87023962
88	MP0009745_abnormal_behavioral_response	0.86719780
89	MP0001119_abnormal_female_reproductive	0.86551791
90	MP0002160_abnormal_reproductive_system	0.81490080
91	MP0003806_abnormal_nucleotide_metabolis	0.79951953
92	MP0001486_abnormal_startle_reflex	0.79770372
93	MP0002557_abnormal_social/conspecific_i	0.79511129
94	MP0005389_reproductive_system_phenotype	0.77681569
95	MP0001919_abnormal_reproductive_system	0.77393178
96	MP0001286_abnormal_eye_development	0.77337161
97	MP0002928_abnormal_bile_duct	0.76805946
98	MP0002272_abnormal_nervous_system	0.75998620
99	MP0000778_abnormal_nervous_system	0.75546893
100	MP0000371_diluted_coat_color	0.75270015

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.19575378
2	Abnormality of midbrain morphology (HP:0002418)	3.13824642
3	Molar tooth sign on MRI (HP:0002419)	3.13824642
4	Pancreatic cysts (HP:0001737)	3.09014497
5	Medial flaring of the eyebrow (HP:0010747)	3.06304177
6	Acute necrotizing encephalopathy (HP:0006965)	3.03354607
7	Methylmalonic acidemia (HP:0002912)	2.95765122
8	Mitochondrial inheritance (HP:0001427)	2.85964793
9	Congenital primary aphakia (HP:0007707)	2.80900370
10	Renal cortical cysts (HP:0000803)	2.76702711
11	Gait imbalance (HP:0002141)	2.75453879
12	Increased CSF lactate (HP:0002490)	2.72671842
13	Acute encephalopathy (HP:0006846)	2.71305944
14	Intestinal atresia (HP:0011100)	2.69710555
15	Colon cancer (HP:0003003)	2.66929936
16	Pendular nystagmus (HP:0012043)	2.66834739
17	Congenital stationary night blindness (HP:0007642)	2.65980661
18	Nephrogenic diabetes insipidus (HP:0009806)	2.63499587
19	Abolished electroretinogram (ERG) (HP:0000550)	2.63166233
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.62772964
21	Nephronophthisis (HP:0000090)	2.62377289
22	True hermaphroditism (HP:0010459)	2.62224805
23	Type I transferrin isoform profile (HP:0003642)	2.61313242
24	Hepatocellular necrosis (HP:0001404)	2.56764571
25	Abnormality of the labia minora (HP:0012880)	2.55844739
26	Progressive macrocephaly (HP:0004481)	2.54091779
27	Chronic hepatic failure (HP:0100626)	2.50695125
28	Genital tract atresia (HP:0001827)	2.48721898
29	Abnormality of the renal cortex (HP:0011035)	2.43697969
30	Vaginal atresia (HP:0000148)	2.43184177
31	Increased hepatocellular lipid droplets (HP:0006565)	2.40620285
32	Lipid accumulation in hepatocytes (HP:0006561)	2.39186855
33	Volvulus (HP:0002580)	2.36641258
34	Hepatic necrosis (HP:0002605)	2.35190016
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.34357141
36	Hyperglycinemia (HP:0002154)	2.29492777
37	Abnormality of the renal medulla (HP:0100957)	2.28740926
38	Inability to walk (HP:0002540)	2.26323369
39	Stomatitis (HP:0010280)	2.24130676
40	Hyperventilation (HP:0002883)	2.23468150
41	Attenuation of retinal blood vessels (HP:0007843)	2.23347703
42	Optic nerve hypoplasia (HP:0000609)	2.19681264
43	Abnormality of macular pigmentation (HP:0008002)	2.18441115
44	3-Methylglutaconic aciduria (HP:0003535)	2.17209626
45	Increased serum lactate (HP:0002151)	2.16963037
46	Bifid tongue (HP:0010297)	2.16544702
47	Progressive inability to walk (HP:0002505)	2.16483880
48	Methylmalonic aciduria (HP:0012120)	2.15746794
49	Abnormal protein glycosylation (HP:0012346)	2.14738279
50	Abnormal glycosylation (HP:0012345)	2.14738279
51	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.14738279
52	Abnormal protein N-linked glycosylation (HP:0012347)	2.14738279
53	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13487939
54	Renal Fanconi syndrome (HP:0001994)	2.13388318
55	Pancreatic islet-cell hyperplasia (HP:0004510)	2.10510197
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.09283199
57	Postaxial hand polydactyly (HP:0001162)	2.08077809
58	Tubulointerstitial nephritis (HP:0001970)	2.07336396
59	Abnormality of methionine metabolism (HP:0010901)	2.06065075
60	Severe visual impairment (HP:0001141)	2.06011883
61	Hyperglycinuria (HP:0003108)	2.04959464
62	Septo-optic dysplasia (HP:0100842)	2.03812269
63	Stenosis of the external auditory canal (HP:0000402)	2.02909058
64	Cerebral edema (HP:0002181)	2.00327854
65	Large for gestational age (HP:0001520)	1.99314975
66	Postaxial foot polydactyly (HP:0001830)	1.97581480
67	Anencephaly (HP:0002323)	1.94380042
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92583385
69	Rhabdomyosarcoma (HP:0002859)	1.91877891
70	Gonadotropin excess (HP:0000837)	1.88407478
71	Lactic acidosis (HP:0003128)	1.86542918
72	Hypoplastic pelvis (HP:0008839)	1.86204941
73	Neoplasm of the adrenal cortex (HP:0100641)	1.86078556
74	Poor coordination (HP:0002370)	1.84940457
75	Optic disc pallor (HP:0000543)	1.84737968
76	Congenital hepatic fibrosis (HP:0002612)	1.84604591
77	Abnormality of glycine metabolism (HP:0010895)	1.81013587
78	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81013587
79	Median cleft lip (HP:0000161)	1.79284049
80	Oligodactyly (hands) (HP:0001180)	1.77695477
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75315577
82	Gaze-evoked nystagmus (HP:0000640)	1.75314836
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.74641474
84	Sclerocornea (HP:0000647)	1.73862751
85	Abnormality of vitamin B metabolism (HP:0004340)	1.73635966
86	Type II lissencephaly (HP:0007260)	1.73059313
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72603081
88	Thyroid-stimulating hormone excess (HP:0002925)	1.70825919
89	Curly hair (HP:0002212)	1.68497276
90	Lethargy (HP:0001254)	1.67868788
91	Cutaneous melanoma (HP:0012056)	1.67825425
92	Lissencephaly (HP:0001339)	1.67791952
93	Decreased testicular size (HP:0008734)	1.67369263
94	Albinism (HP:0001022)	1.67351845
95	Abnormality of chromosome stability (HP:0003220)	1.64317644
96	Respiratory failure (HP:0002878)	1.64191007
97	Hepatoblastoma (HP:0002884)	1.63971689
98	Hypothermia (HP:0002045)	1.63455081
99	Cellular immunodeficiency (HP:0005374)	1.61664243
100	Ketoacidosis (HP:0001993)	1.59847182

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.46094701
2	WNK3	3.25350265
3	CDK19	2.91003464
4	MAP4K2	2.74688172
5	TNIK	2.71475759
6	NUAK1	2.63636552
7	BCR	2.37677767
8	MAP3K4	2.10175751
9	TRIM28	2.08878177
10	ACVR1B	2.06418259
11	EIF2AK3	2.00486273
12	BMPR1B	1.93920712
13	GRK1	1.90043353
14	MKNK2	1.89644654
15	STK38L	1.87777933
16	OXSR1	1.79200933
17	ZAK	1.76579996
18	ADRBK2	1.75762463
19	CASK	1.69028548
20	STK16	1.58626306
21	PINK1	1.43845461
22	PLK3	1.40708823
23	ERBB3	1.36288849
24	MAPK13	1.35638031
25	BCKDK	1.34264906
26	MST4	1.32955588
27	MKNK1	1.32106304
28	BRSK2	1.29047590
29	STK39	1.27574523
30	TAOK3	1.25672993
31	MAP2K7	1.25342023
32	WNK4	1.23674526
33	INSRR	1.23219996
34	TAF1	1.22923048
35	NLK	1.20843302
36	CSNK1G1	1.18811759
37	NEK1	1.18148977
38	TSSK6	1.17426599
39	PLK4	1.15016849
40	PLK2	1.11993211
41	VRK1	1.10673803
42	SRPK1	1.09608859
43	DYRK2	1.08209192
44	CAMK1D	1.07819211
45	DYRK3	1.07533515
46	TXK	1.04897638
47	AKT3	1.01678514
48	CSNK1G3	0.93246692
49	BUB1	0.89477494
50	CSNK1G2	0.84604828
51	CAMK1G	0.83395726
52	PRKCG	0.83328428
53	PRKCE	0.81980631
54	CSNK1A1L	0.81465735
55	PLK1	0.76936271
56	FLT3	0.76321554
57	PAK3	0.76100305
58	TTK	0.73745527
59	ATR	0.72126199
60	TLK1	0.69638830
61	ATM	0.66763491
62	STK3	0.65643297
63	MAP2K6	0.64840098
64	CDC7	0.61747970
65	TEC	0.60273831
66	CHEK2	0.54659561
67	PRKD3	0.52445303
68	CAMKK2	0.50423328
69	KIT	0.45063003
70	PASK	0.45036084
71	DYRK1A	0.43597537
72	PBK	0.43462175
73	CSNK2A2	0.43321910
74	VRK2	0.43201702
75	PRKCI	0.43021280
76	AURKB	0.41529909
77	SGK2	0.41338618
78	PRKCZ	0.40284650
79	FER	0.39370344
80	OBSCN	0.39228127
81	GRK7	0.37929261
82	TGFBR1	0.36657934
83	PRKCQ	0.36239483
84	RPS6KA5	0.36024290
85	PRKDC	0.35952071
86	CSNK1A1	0.35869237
87	CSNK2A1	0.35358457
88	CHEK1	0.35198419
89	PRKACA	0.34212090
90	EPHA3	0.33137257
91	TNK2	0.32447710
92	EGFR	0.32432076
93	DAPK1	0.32012806
94	ADRBK1	0.31825837
95	STK11	0.31386912
96	FGFR2	0.30411136
97	MAP2K4	0.29652344
98	ERBB4	0.29055613
99	PNCK	0.28996370
100	LIMK1	0.28975616

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.49286236
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.99675961
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.78674947
4	RNA polymerase_Homo sapiens_hsa03020	2.77364335
5	Proteasome_Homo sapiens_hsa03050	2.72789539
6	Propanoate metabolism_Homo sapiens_hsa00640	2.58292355
7	Basal transcription factors_Homo sapiens_hsa03022	2.58061093
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.53982000
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42380976
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36927934
11	Butanoate metabolism_Homo sapiens_hsa00650	2.35317525
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.31694442
13	Parkinsons disease_Homo sapiens_hsa05012	2.07367246
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.02426154
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00132577
16	Homologous recombination_Homo sapiens_hsa03440	1.96336464
17	RNA degradation_Homo sapiens_hsa03018	1.86061115
18	Fatty acid elongation_Homo sapiens_hsa00062	1.84960169
19	Peroxisome_Homo sapiens_hsa04146	1.83961530
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.78054771
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.75595785
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.71586937
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69063969
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59651435
25	Phototransduction_Homo sapiens_hsa04744	1.58631434
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.54174913
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.45728662
28	Huntingtons disease_Homo sapiens_hsa05016	1.42299353
29	RNA transport_Homo sapiens_hsa03013	1.40339593
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39679871
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.38186199
32	Fatty acid degradation_Homo sapiens_hsa00071	1.29161027
33	Mismatch repair_Homo sapiens_hsa03430	1.25328712
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.24708059
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.20382243
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.17424891
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16724136
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.16359441
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13422882
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11178779
41	Ribosome_Homo sapiens_hsa03010	1.07107904
42	Alzheimers disease_Homo sapiens_hsa05010	1.06563945
43	Purine metabolism_Homo sapiens_hsa00230	1.04285348
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97988897
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96537895
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96430976
47	Spliceosome_Homo sapiens_hsa03040	0.96315131
48	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.95155466
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93814857
50	Taste transduction_Homo sapiens_hsa04742	0.93086172
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92333150
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91625659
53	One carbon pool by folate_Homo sapiens_hsa00670	0.88437992
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85796098
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84810159
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84482604
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82654700
58	Base excision repair_Homo sapiens_hsa03410	0.80888791
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78812416
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78704709
61	Olfactory transduction_Homo sapiens_hsa04740	0.77997866
62	Regulation of autophagy_Homo sapiens_hsa04140	0.77457912
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75075145
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74815696
65	Metabolic pathways_Homo sapiens_hsa01100	0.72658853
66	Sulfur relay system_Homo sapiens_hsa04122	0.71116997
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.70700148
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.70162310
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70036008
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.69130753
71	DNA replication_Homo sapiens_hsa03030	0.68865135
72	Nicotine addiction_Homo sapiens_hsa05033	0.68860678
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68399775
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66364555
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65279915
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64709954
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57239442
78	Retinol metabolism_Homo sapiens_hsa00830	0.57166694
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55607935
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52503875
81	Glutathione metabolism_Homo sapiens_hsa00480	0.50809403
82	Caffeine metabolism_Homo sapiens_hsa00232	0.45690594
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43307377
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.41312322
85	Asthma_Homo sapiens_hsa05310	0.40126921
86	Cell cycle_Homo sapiens_hsa04110	0.35250255
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.32997323
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31809862
89	Carbon metabolism_Homo sapiens_hsa01200	0.30353186
90	p53 signaling pathway_Homo sapiens_hsa04115	0.28558958
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28401719
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27439904
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.27416697
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.22366688
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.21483897
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20759286
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.17619820
98	Sulfur metabolism_Homo sapiens_hsa00920	0.17410804
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16014570
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.15754954

ZNF613

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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