ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.35418516
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.87264972
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.87264972
4	regulation of translation, ncRNA-mediated (GO:0045974)	3.87264972
5	neural tube formation (GO:0001841)	3.69730745
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.68129745
7	DNA double-strand break processing (GO:0000729)	3.63357889
8	behavioral response to nicotine (GO:0035095)	3.61156203
9	kidney morphogenesis (GO:0060993)	3.57833738
10	regulation of mitotic spindle checkpoint (GO:1903504)	3.56628065
11	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.56628065
12	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.55060526
13	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.55060526
14	regulation of posttranscriptional gene silencing (GO:0060147)	3.51053973
15	regulation of gene silencing by miRNA (GO:0060964)	3.51053973
16	regulation of gene silencing by RNA (GO:0060966)	3.51053973
17	photoreceptor cell maintenance (GO:0045494)	3.34835022
18	maturation of 5.8S rRNA (GO:0000460)	3.30126662
19	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.29705226
20	rRNA catabolic process (GO:0016075)	3.18098296
21	synapsis (GO:0007129)	3.04999849
22	replication fork processing (GO:0031297)	3.02261761
23	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01361827
24	resolution of meiotic recombination intermediates (GO:0000712)	2.98180601
25	epithelial cilium movement (GO:0003351)	2.97910904
26	regulation of hippo signaling (GO:0035330)	2.96913903
27	DNA replication-dependent nucleosome organization (GO:0034723)	2.95617220
28	DNA replication-dependent nucleosome assembly (GO:0006335)	2.95617220
29	histone mRNA metabolic process (GO:0008334)	2.95564119
30	kynurenine metabolic process (GO:0070189)	2.94144939
31	nonmotile primary cilium assembly (GO:0035058)	2.93575851
32	reciprocal meiotic recombination (GO:0007131)	2.91971309
33	reciprocal DNA recombination (GO:0035825)	2.91971309
34	water-soluble vitamin biosynthetic process (GO:0042364)	2.89832277
35	chromatin remodeling at centromere (GO:0031055)	2.89524450
36	ncRNA catabolic process (GO:0034661)	2.89067812
37	indolalkylamine metabolic process (GO:0006586)	2.87610445
38	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.85792776
39	respiratory chain complex IV assembly (GO:0008535)	2.84474265
40	intra-S DNA damage checkpoint (GO:0031573)	2.83803903
41	mitochondrial DNA replication (GO:0006264)	2.83049729
42	pseudouridine synthesis (GO:0001522)	2.82626752
43	regulation of hexokinase activity (GO:1903299)	2.82279283
44	regulation of glucokinase activity (GO:0033131)	2.82279283
45	L-fucose catabolic process (GO:0042355)	2.81240678
46	fucose catabolic process (GO:0019317)	2.81240678
47	L-fucose metabolic process (GO:0042354)	2.81240678
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79582771
49	termination of RNA polymerase III transcription (GO:0006386)	2.79582771
50	response to X-ray (GO:0010165)	2.79089409
51	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.78748449
52	DNA integration (GO:0015074)	2.77745118
53	somite development (GO:0061053)	2.76322242
54	prenylation (GO:0097354)	2.75658618
55	protein prenylation (GO:0018342)	2.75658618
56	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.72512782
57	protein-cofactor linkage (GO:0018065)	2.72201700
58	indole-containing compound catabolic process (GO:0042436)	2.71069924
59	indolalkylamine catabolic process (GO:0046218)	2.71069924
60	tryptophan catabolic process (GO:0006569)	2.71069924
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.69557601
62	pyrimidine nucleobase catabolic process (GO:0006208)	2.69203730
63	lysine metabolic process (GO:0006553)	2.68408773
64	lysine catabolic process (GO:0006554)	2.68408773
65	recombinational repair (GO:0000725)	2.67564113
66	meiotic chromosome segregation (GO:0045132)	2.67050656
67	regulation of DNA endoreduplication (GO:0032875)	2.66746370
68	double-strand break repair via nonhomologous end joining (GO:0006303)	2.66288427
69	non-recombinational repair (GO:0000726)	2.66288427
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65084972
71	double-strand break repair via homologous recombination (GO:0000724)	2.64415403
72	protein neddylation (GO:0045116)	2.64182848
73	cilium morphogenesis (GO:0060271)	2.64031093
74	regulation of centriole replication (GO:0046599)	2.63729087
75	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62690974
76	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.62182093
77	peptidyl-histidine modification (GO:0018202)	2.60775489
78	cytochrome complex assembly (GO:0017004)	2.58972295
79	CENP-A containing nucleosome assembly (GO:0034080)	2.58782797
80	regulation of helicase activity (GO:0051095)	2.58694539
81	aspartate family amino acid catabolic process (GO:0009068)	2.57003973
82	negative regulation of DNA recombination (GO:0045910)	2.55068099
83	tryptophan metabolic process (GO:0006568)	2.48908092
84	tRNA processing (GO:0008033)	2.47212887
85	positive regulation of mRNA processing (GO:0050685)	2.46649670
86	protein K6-linked ubiquitination (GO:0085020)	2.46053038
87	histone mRNA catabolic process (GO:0071044)	2.45661563
88	piRNA metabolic process (GO:0034587)	2.43964688
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.43964117
90	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.43964117
91	isotype switching (GO:0045190)	2.43964117
92	cornea development in camera-type eye (GO:0061303)	2.43861979
93	DNA deamination (GO:0045006)	2.43846551
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.43794432
95	histone exchange (GO:0043486)	2.43764134
96	DNA replication checkpoint (GO:0000076)	2.43554792
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.42211074
98	protein complex biogenesis (GO:0070271)	2.41269874
99	DNA methylation involved in gamete generation (GO:0043046)	2.39646665
100	positive regulation of mRNA 3-end processing (GO:0031442)	2.39263226

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.98715040
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.13378026
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.90751493
4	VDR_22108803_ChIP-Seq_LS180_Human	2.73889341
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.69292340
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.62097309
7	EWS_26573619_Chip-Seq_HEK293_Human	2.59788236
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.54142870
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46575088
10	FUS_26573619_Chip-Seq_HEK293_Human	2.45309813
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.41312408
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40237204
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.37958780
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36927780
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36769580
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34822646
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32064592
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23654672
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.20048513
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.16215841
21	P300_19829295_ChIP-Seq_ESCs_Human	2.11805075
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.00492985
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86240583
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83773615
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81518823
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79120628
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77924953
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64228850
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60925901
30	E2F7_22180533_ChIP-Seq_HELA_Human	1.60224151
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.58165708
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57193719
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55997562
34	* MYC_18940864_ChIP-ChIP_HL60_Human	1.53937571
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52299611
36	* VDR_23849224_ChIP-Seq_CD4+_Human	1.51569614
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50415031
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49053243
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47307905
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45888929
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44513930
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43302314
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42558233
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41702506
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39380828
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.38275026
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37345979
48	STAT3_23295773_ChIP-Seq_U87_Human	1.37156613
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.36531182
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.34761191
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34761191
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34184129
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.33848440
54	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31966169
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30464711
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28938533
57	TCF4_23295773_ChIP-Seq_U87_Human	1.27333721
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25957859
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23098271
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.23001617
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.21655974
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20956349
63	AR_25329375_ChIP-Seq_VCAP_Human	1.20809438
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20535520
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20047698
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19959534
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18163765
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18008776
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18008776
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17422202
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16384218
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16192465
73	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15643132
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.14457475
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14386469
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14072294
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13585966
78	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13585966
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13381442
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12083084
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09181289
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08742993
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07193298
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07193298
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07102465
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06141308
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04229195
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03134863
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01553310
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98126674
91	JUN_21703547_ChIP-Seq_K562_Human	0.97480522
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.97474854
93	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96185321
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94042451
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.93675729
96	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.93472259
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93336494
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.92427161
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92253095
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92215858

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.84935523
2	MP0006292_abnormal_olfactory_placode	2.75256503
3	MP0008058_abnormal_DNA_repair	2.59410872
4	MP0003718_maternal_effect	2.51037474
5	MP0003136_yellow_coat_color	2.47212969
6	MP0003195_calcinosis	2.45749225
7	MP0003787_abnormal_imprinting	2.43411118
8	MP0006072_abnormal_retinal_apoptosis	2.17338200
9	MP0002102_abnormal_ear_morphology	2.12188813
10	MP0001984_abnormal_olfaction	2.05629865
11	MP0003890_abnormal_embryonic-extraembry	1.97712800
12	MP0002736_abnormal_nociception_after	1.97606823
13	MP0005253_abnormal_eye_physiology	1.96569532
14	MP0003121_genomic_imprinting	1.96058193
15	MP0003693_abnormal_embryo_hatching	1.89490746
16	MP0009697_abnormal_copulation	1.88948101
17	MP0004147_increased_porphyrin_level	1.87917322
18	MP0005551_abnormal_eye_electrophysiolog	1.86189020
19	MP0001293_anophthalmia	1.84678265
20	MP0010094_abnormal_chromosome_stability	1.84591808
21	MP0001529_abnormal_vocalization	1.83701608
22	MP0003011_delayed_dark_adaptation	1.80115352
23	MP0004133_heterotaxia	1.77125180
24	MP0002837_dystrophic_cardiac_calcinosis	1.75932198
25	MP0002938_white_spotting	1.68117392
26	MP0008057_abnormal_DNA_replication	1.67508779
27	MP0003119_abnormal_digestive_system	1.67268712
28	MP0001968_abnormal_touch/_nociception	1.61816837
29	MP0003252_abnormal_bile_duct	1.57276484
30	MP0000647_abnormal_sebaceous_gland	1.57155217
31	MP0000383_abnormal_hair_follicle	1.56586150
32	MP0003567_abnormal_fetal_cardiomyocyte	1.55943338
33	MP0008789_abnormal_olfactory_epithelium	1.54095656
34	MP0003937_abnormal_limbs/digits/tail_de	1.51104941
35	MP0001986_abnormal_taste_sensitivity	1.50429469
36	MP0003941_abnormal_skin_development	1.49038390
37	MP0000427_abnormal_hair_cycle	1.46383745
38	MP0002638_abnormal_pupillary_reflex	1.41678747
39	MP0006276_abnormal_autonomic_nervous	1.41365591
40	MP0000631_abnormal_neuroendocrine_gland	1.39002906
41	MP0000569_abnormal_digit_pigmentation	1.33050158
42	MP0005646_abnormal_pituitary_gland	1.31495431
43	MP0002751_abnormal_autonomic_nervous	1.30111800
44	MP0002234_abnormal_pharynx_morphology	1.26781920
45	MP0002653_abnormal_ependyma_morphology	1.26390328
46	MP0009046_muscle_twitch	1.22614282
47	MP0003122_maternal_imprinting	1.21879885
48	MP0005084_abnormal_gallbladder_morpholo	1.21796530
49	MP0002928_abnormal_bile_duct	1.21113441
50	MP0006035_abnormal_mitochondrial_morpho	1.20941741
51	MP0001486_abnormal_startle_reflex	1.16931105
52	MP0005391_vision/eye_phenotype	1.14743347
53	MP0005499_abnormal_olfactory_system	1.14500783
54	MP0005394_taste/olfaction_phenotype	1.14500783
55	MP0002160_abnormal_reproductive_system	1.12576426
56	MP0008872_abnormal_physiological_respon	1.12041371
57	MP0001485_abnormal_pinna_reflex	1.10966817
58	MP0005085_abnormal_gallbladder_physiolo	1.10587448
59	MP0005187_abnormal_penis_morphology	1.09729072
60	MP0002233_abnormal_nose_morphology	1.09438493
61	MP0001286_abnormal_eye_development	1.07242306
62	MP0008875_abnormal_xenobiotic_pharmacok	1.07196701
63	MP0009745_abnormal_behavioral_response	1.06436661
64	MP0003646_muscle_fatigue	1.06067380
65	MP0003880_abnormal_central_pattern	1.05710539
66	MP0003111_abnormal_nucleus_morphology	1.04419217
67	MP0004145_abnormal_muscle_electrophysio	1.04117179
68	MP0004957_abnormal_blastocyst_morpholog	1.00519473
69	MP0001929_abnormal_gametogenesis	0.99719202
70	MP0003786_premature_aging	0.99700298
71	MP0000372_irregular_coat_pigmentation	0.98318798
72	MP0002210_abnormal_sex_determination	0.95821308
73	MP0003698_abnormal_male_reproductive	0.95710890
74	MP0008932_abnormal_embryonic_tissue	0.94907235
75	MP0005645_abnormal_hypothalamus_physiol	0.94798817
76	MP0001501_abnormal_sleep_pattern	0.93815141
77	MP0005195_abnormal_posterior_eye	0.93053925
78	MP0002752_abnormal_somatic_nervous	0.92272809
79	MP0005389_reproductive_system_phenotype	0.92070667
80	MP0010678_abnormal_skin_adnexa	0.91743347
81	MP0005171_absent_coat_pigmentation	0.91687739
82	MP0005410_abnormal_fertilization	0.90134633
83	MP0001188_hyperpigmentation	0.89686816
84	MP0000653_abnormal_sex_gland	0.88922751
85	MP0000778_abnormal_nervous_system	0.88579568
86	MP0008995_early_reproductive_senescence	0.88567973
87	MP0004043_abnormal_pH_regulation	0.88503786
88	MP0002557_abnormal_social/conspecific_i	0.87892811
89	MP0001145_abnormal_male_reproductive	0.86362678
90	MP0003283_abnormal_digestive_organ	0.85639666
91	MP0000049_abnormal_middle_ear	0.85163729
92	MP0001764_abnormal_homeostasis	0.85069454
93	MP0003077_abnormal_cell_cycle	0.84219730
94	MP0005367_renal/urinary_system_phenotyp	0.83487368
95	MP0000516_abnormal_urinary_system	0.83487368
96	MP0002272_abnormal_nervous_system	0.82455104
97	MP0008775_abnormal_heart_ventricle	0.81542302
98	MP0002572_abnormal_emotion/affect_behav	0.79142526
99	MP0004142_abnormal_muscle_tone	0.78599794
100	MP0002184_abnormal_innervation	0.78171625

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.92453608
2	Pancreatic fibrosis (HP:0100732)	3.86967255
3	Nephronophthisis (HP:0000090)	3.48938624
4	Colon cancer (HP:0003003)	3.41599839
5	Abnormal biliary tract physiology (HP:0012439)	3.41535174
6	Bile duct proliferation (HP:0001408)	3.41535174
7	Abnormality of the renal medulla (HP:0100957)	3.38746032
8	Abnormality of the renal cortex (HP:0011035)	3.19366836
9	Abnormality of midbrain morphology (HP:0002418)	3.07662823
10	Molar tooth sign on MRI (HP:0002419)	3.07662823
11	True hermaphroditism (HP:0010459)	3.05947628
12	Type II lissencephaly (HP:0007260)	3.00590999
13	Hyperglycinemia (HP:0002154)	2.94132041
14	Medial flaring of the eyebrow (HP:0010747)	2.85590787
15	Abolished electroretinogram (ERG) (HP:0000550)	2.69780798
16	Abnormality of the labia minora (HP:0012880)	2.56461320
17	Intestinal atresia (HP:0011100)	2.54134225
18	Renal cortical cysts (HP:0000803)	2.53511996
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.52069477
20	Hypoplastic pelvis (HP:0008839)	2.51743777
21	Meckel diverticulum (HP:0002245)	2.45405834
22	Genital tract atresia (HP:0001827)	2.45026803
23	Lissencephaly (HP:0001339)	2.44815589
24	Cystic liver disease (HP:0006706)	2.43426325
25	Tubular atrophy (HP:0000092)	2.43046914
26	Congenital stationary night blindness (HP:0007642)	2.41215292
27	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.40119238
28	Abnormality of the ileum (HP:0001549)	2.38328473
29	Vaginal atresia (HP:0000148)	2.37667809
30	Congenital primary aphakia (HP:0007707)	2.37457938
31	Retinal dysplasia (HP:0007973)	2.37147537
32	Bilateral microphthalmos (HP:0007633)	2.35964909
33	Progressive inability to walk (HP:0002505)	2.34818133
34	Gait imbalance (HP:0002141)	2.34172540
35	Nephrogenic diabetes insipidus (HP:0009806)	2.33302758
36	Methylmalonic acidemia (HP:0002912)	2.31330276
37	Chronic hepatic failure (HP:0100626)	2.30843626
38	Pendular nystagmus (HP:0012043)	2.29803146
39	Ependymoma (HP:0002888)	2.27778908
40	Protruding tongue (HP:0010808)	2.25414682
41	Inability to walk (HP:0002540)	2.22354457
42	Short tibia (HP:0005736)	2.18229185
43	Hyperglycinuria (HP:0003108)	2.13725960
44	Abnormality of serine family amino acid metabolism (HP:0010894)	2.07733843
45	Abnormality of glycine metabolism (HP:0010895)	2.07733843
46	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.07488950
47	Chromsome breakage (HP:0040012)	2.07122120
48	Supernumerary spleens (HP:0009799)	2.06840588
49	Chorioretinal atrophy (HP:0000533)	2.05504294
50	Abnormality of chromosome stability (HP:0003220)	2.01995673
51	Enlarged kidneys (HP:0000105)	2.01259096
52	Congenital hepatic fibrosis (HP:0002612)	1.99390044
53	Gastrointestinal atresia (HP:0002589)	1.98693930
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97420663
55	Gaze-evoked nystagmus (HP:0000640)	1.97198768
56	Optic nerve hypoplasia (HP:0000609)	1.96643978
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95028973
58	Abnormality of alanine metabolism (HP:0010916)	1.95028973
59	Hyperalaninemia (HP:0003348)	1.95028973
60	Sclerocornea (HP:0000647)	1.95013277
61	Oligodactyly (hands) (HP:0001180)	1.93466269
62	Dandy-Walker malformation (HP:0001305)	1.93085131
63	Glioma (HP:0009733)	1.92322799
64	Increased corneal curvature (HP:0100692)	1.91290549
65	Keratoconus (HP:0000563)	1.91290549
66	Abnormal biliary tract morphology (HP:0012440)	1.91142785
67	Congenital, generalized hypertrichosis (HP:0004540)	1.90544308
68	Attenuation of retinal blood vessels (HP:0007843)	1.89682078
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88628403
70	Small hand (HP:0200055)	1.88159726
71	Abnormality of serum amino acid levels (HP:0003112)	1.87521033
72	Sloping forehead (HP:0000340)	1.81882648
73	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.80211954
74	Anencephaly (HP:0002323)	1.79919660
75	Birth length less than 3rd percentile (HP:0003561)	1.79445517
76	Cupped ear (HP:0000378)	1.79254043
77	Volvulus (HP:0002580)	1.79134214
78	Anophthalmia (HP:0000528)	1.78055966
79	Cerebellar dysplasia (HP:0007033)	1.78005412
80	Pancreatic islet-cell hyperplasia (HP:0004510)	1.75890737
81	Abnormality of the astrocytes (HP:0100707)	1.74867066
82	Astrocytoma (HP:0009592)	1.74867066
83	Astigmatism (HP:0000483)	1.74637055
84	Lipid accumulation in hepatocytes (HP:0006561)	1.73779898
85	Patellar aplasia (HP:0006443)	1.71773163
86	Multicystic kidney dysplasia (HP:0000003)	1.70729224
87	Abnormality of the duodenum (HP:0002246)	1.70676855
88	Methylmalonic aciduria (HP:0012120)	1.70640683
89	Poor coordination (HP:0002370)	1.69912350
90	Acute necrotizing encephalopathy (HP:0006965)	1.69502796
91	Genetic anticipation (HP:0003743)	1.69467526
92	Bifid tongue (HP:0010297)	1.69234472
93	Renal hypoplasia (HP:0000089)	1.68892517
94	Abnormality of the preputium (HP:0100587)	1.68540044
95	Preaxial hand polydactyly (HP:0001177)	1.68414063
96	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.67965346
97	Triphalangeal thumb (HP:0001199)	1.67412294
98	Small intestinal stenosis (HP:0012848)	1.67257957
99	Duodenal stenosis (HP:0100867)	1.67257957
100	Postaxial hand polydactyly (HP:0001162)	1.67051815

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.03349141
2	BMPR1B	3.21192081
3	WNK3	3.09768815
4	ZAK	3.01410372
5	NUAK1	2.84086516
6	ADRBK2	2.80027851
7	MKNK2	2.34957067
8	MAP3K4	2.21140214
9	CASK	2.19841050
10	SRPK1	2.17589129
11	ACVR1B	1.98335771
12	GRK1	1.86650882
13	MKNK1	1.85227083
14	MAP4K2	1.84814766
15	STK38L	1.76567026
16	CDC7	1.66797089
17	PLK3	1.66028237
18	TRIM28	1.54926978
19	INSRR	1.54104209
20	BRSK2	1.49805503
21	TSSK6	1.47030049
22	STK16	1.44182097
23	TTK	1.42274640
24	TLK1	1.40886009
25	TGFBR1	1.40676207
26	WNK4	1.38149045
27	OXSR1	1.34485013
28	MAP2K7	1.33713276
29	VRK2	1.31882909
30	TAF1	1.31717612
31	MAPK13	1.29220218
32	CSNK1G1	1.26832560
33	CSNK1A1L	1.23267902
34	VRK1	1.21247862
35	ERBB3	1.19524907
36	CSNK1G2	1.18932918
37	CSNK1G3	1.18632543
38	TNIK	1.18288456
39	BCR	1.16742907
40	STK3	1.15058595
41	MST4	1.13991422
42	PINK1	1.12590826
43	LATS1	1.12271369
44	PLK2	1.07548658
45	WEE1	1.07029063
46	EIF2AK3	1.05591405
47	TAOK3	1.01973694
48	BCKDK	0.99816799
49	PLK1	0.99575779
50	DYRK3	0.99547369
51	PIK3CA	0.97902735
52	TIE1	0.96760462
53	PBK	0.95237448
54	STK39	0.93013291
55	ATR	0.92669967
56	PLK4	0.92482708
57	DYRK2	0.90047962
58	FGFR2	0.88210799
59	PASK	0.81993101
60	CHEK2	0.80862685
61	PAK3	0.78929183
62	PRKCE	0.78552441
63	MAP3K7	0.74281013
64	EPHA4	0.74132698
65	NTRK3	0.72245020
66	ATM	0.71147033
67	CDK19	0.66078114
68	NEK2	0.65101168
69	ADRBK1	0.64007597
70	PRKCG	0.62809509
71	TEC	0.58845400
72	MAP3K13	0.57098671
73	RPS6KA4	0.52974260
74	BRD4	0.50381233
75	RPS6KA5	0.48753656
76	NME1	0.48344954
77	MARK1	0.48055586
78	PNCK	0.45032616
79	CSNK1D	0.44219263
80	PHKG2	0.41024763
81	PHKG1	0.41024763
82	CSNK1A1	0.39999652
83	CHEK1	0.39536134
84	BUB1	0.38815401
85	EIF2AK2	0.38465519
86	CSNK1E	0.38079797
87	OBSCN	0.37188583
88	ERBB4	0.36858642
89	CHUK	0.36488525
90	FLT3	0.36182653
91	CDK1	0.34708203
92	PRKAA2	0.34488761
93	AKT3	0.33771869
94	CSNK2A1	0.33500906
95	NEK1	0.32352664
96	PRKCQ	0.31948345
97	PRKDC	0.31842391
98	CDK3	0.31493986
99	CAMK2A	0.31256727
100	PRKACB	0.30943255

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	2.65934433
2	RNA polymerase_Homo sapiens_hsa03020	2.64430085
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.52273111
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.50084593
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.45383642
6	Homologous recombination_Homo sapiens_hsa03440	2.41660695
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39644010
8	Protein export_Homo sapiens_hsa03060	2.34317596
9	Basal transcription factors_Homo sapiens_hsa03022	2.30515221
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26998818
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10854800
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.93249746
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91323197
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89151134
15	RNA degradation_Homo sapiens_hsa03018	1.88737596
16	Propanoate metabolism_Homo sapiens_hsa00640	1.87279167
17	Phototransduction_Homo sapiens_hsa04744	1.85106331
18	One carbon pool by folate_Homo sapiens_hsa00670	1.77510938
19	Butanoate metabolism_Homo sapiens_hsa00650	1.71683413
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69170338
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.68728618
22	Mismatch repair_Homo sapiens_hsa03430	1.67814463
23	RNA transport_Homo sapiens_hsa03013	1.60317950
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60146408
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.55207381
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52275807
27	Peroxisome_Homo sapiens_hsa04146	1.43264014
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41329035
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.39464938
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.39180499
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.36841883
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.36597406
33	Caffeine metabolism_Homo sapiens_hsa00232	1.35174491
34	Nicotine addiction_Homo sapiens_hsa05033	1.33417218
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32432963
36	Olfactory transduction_Homo sapiens_hsa04740	1.29948317
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.26112565
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23575107
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.23333999
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18578931
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16023104
42	Spliceosome_Homo sapiens_hsa03040	1.14574586
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13792153
44	Purine metabolism_Homo sapiens_hsa00230	1.13745082
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12078623
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10701996
47	Retinol metabolism_Homo sapiens_hsa00830	1.09101654
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02862723
49	Proteasome_Homo sapiens_hsa03050	1.02666599
50	Base excision repair_Homo sapiens_hsa03410	1.02357590
51	Parkinsons disease_Homo sapiens_hsa05012	1.01623329
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95993408
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93163969
54	Taste transduction_Homo sapiens_hsa04742	0.91852184
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87045133
56	ABC transporters_Homo sapiens_hsa02010	0.86619036
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86371458
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84648233
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84340248
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83603443
61	Huntingtons disease_Homo sapiens_hsa05016	0.83393826
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80621638
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.79353836
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78278507
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.77945433
66	DNA replication_Homo sapiens_hsa03030	0.77786585
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72844035
68	Cell cycle_Homo sapiens_hsa04110	0.71847716
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.71793896
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.70217400
71	Circadian rhythm_Homo sapiens_hsa04710	0.69788326
72	Metabolic pathways_Homo sapiens_hsa01100	0.69226895
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67468170
74	Regulation of autophagy_Homo sapiens_hsa04140	0.62814339
75	Long-term depression_Homo sapiens_hsa04730	0.62685629
76	Sulfur metabolism_Homo sapiens_hsa00920	0.62494766
77	Fatty acid elongation_Homo sapiens_hsa00062	0.60158449
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.58607164
79	p53 signaling pathway_Homo sapiens_hsa04115	0.56126150
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.54207890
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52646090
82	Glutathione metabolism_Homo sapiens_hsa00480	0.50755198
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50716274
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49889613
85	Lysine degradation_Homo sapiens_hsa00310	0.47491682
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.47262787
87	Circadian entrainment_Homo sapiens_hsa04713	0.46187954
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46058830
89	Serotonergic synapse_Homo sapiens_hsa04726	0.45347143
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.44600598
91	Alzheimers disease_Homo sapiens_hsa05010	0.44232295
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43648876
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42813646
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41936336
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39464451
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39033106
97	Asthma_Homo sapiens_hsa05310	0.38221011
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.36388974
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35639082
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34955485

ZNF616

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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