ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.69948440
2	DNA deamination (GO:0045006)	3.76986453
3	replication fork processing (GO:0031297)	3.69664930
4	DNA double-strand break processing (GO:0000729)	3.64582869
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56829340
6	respiratory chain complex IV assembly (GO:0008535)	3.47860340
7	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.47603845
8	protein complex biogenesis (GO:0070271)	3.41554644
9	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.40620699
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.40306373
11	mitochondrial respiratory chain complex assembly (GO:0033108)	3.28891944
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26713269
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22141634
14	NADH dehydrogenase complex assembly (GO:0010257)	3.22141634
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22141634
16	centriole replication (GO:0007099)	3.19529631
17	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17411954
18	L-fucose catabolic process (GO:0042355)	3.13433253
19	fucose catabolic process (GO:0019317)	3.13433253
20	L-fucose metabolic process (GO:0042354)	3.13433253
21	cytochrome complex assembly (GO:0017004)	3.10708136
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.10102854
23	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.08338792
24	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.08338792
25	protein-cofactor linkage (GO:0018065)	3.02807453
26	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.01466656
27	regulation of mitotic spindle checkpoint (GO:1903504)	3.01466656
28	negative regulation of telomere maintenance (GO:0032205)	3.01270777
29	chromatin remodeling at centromere (GO:0031055)	2.97692225
30	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.96925220
31	reciprocal meiotic recombination (GO:0007131)	2.95319647
32	reciprocal DNA recombination (GO:0035825)	2.95319647
33	pseudouridine synthesis (GO:0001522)	2.95170736
34	platelet dense granule organization (GO:0060155)	2.94528479
35	recombinational repair (GO:0000725)	2.92510555
36	double-strand break repair via homologous recombination (GO:0000724)	2.90605549
37	epithelial cilium movement (GO:0003351)	2.89833845
38	response to pheromone (GO:0019236)	2.87643425
39	peptidyl-histidine modification (GO:0018202)	2.87402927
40	ubiquinone biosynthetic process (GO:0006744)	2.84833171
41	synapsis (GO:0007129)	2.82714936
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.82024256
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.82024256
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81858657
45	DNA catabolic process, exonucleolytic (GO:0000738)	2.80605653
46	nonmotile primary cilium assembly (GO:0035058)	2.78961281
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76882740
48	ubiquinone metabolic process (GO:0006743)	2.76188795
49	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75964783
50	CENP-A containing nucleosome assembly (GO:0034080)	2.74618489
51	cullin deneddylation (GO:0010388)	2.74262951
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72271223
53	proteasome assembly (GO:0043248)	2.71362146
54	kynurenine metabolic process (GO:0070189)	2.70734385
55	protein K6-linked ubiquitination (GO:0085020)	2.70040449
56	DNA damage response, detection of DNA damage (GO:0042769)	2.68022777
57	protein polyglutamylation (GO:0018095)	2.67716033
58	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.67594172
59	regulation of translation, ncRNA-mediated (GO:0045974)	2.67594172
60	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.67594172
61	pyrimidine nucleobase catabolic process (GO:0006208)	2.67582100
62	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65332118
63	cellular ketone body metabolic process (GO:0046950)	2.63388883
64	DNA replication checkpoint (GO:0000076)	2.62924792
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.60807098
66	tRNA processing (GO:0008033)	2.59998828
67	regulation of cilium movement (GO:0003352)	2.59560209
68	protein deneddylation (GO:0000338)	2.59491482
69	intraciliary transport (GO:0042073)	2.58462147
70	kidney morphogenesis (GO:0060993)	2.58371304
71	indole-containing compound catabolic process (GO:0042436)	2.58303936
72	indolalkylamine catabolic process (GO:0046218)	2.58303936
73	tryptophan catabolic process (GO:0006569)	2.58303936
74	DNA demethylation (GO:0080111)	2.57398637
75	resolution of meiotic recombination intermediates (GO:0000712)	2.57313471
76	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.56561983
77	ATP synthesis coupled proton transport (GO:0015986)	2.56561983
78	indolalkylamine metabolic process (GO:0006586)	2.55644672
79	piRNA metabolic process (GO:0034587)	2.55537921
80	histone exchange (GO:0043486)	2.54949810
81	mannosylation (GO:0097502)	2.54599541
82	DNA replication-dependent nucleosome organization (GO:0034723)	2.54151659
83	DNA replication-dependent nucleosome assembly (GO:0006335)	2.54151659
84	maturation of 5.8S rRNA (GO:0000460)	2.54076678
85	neural tube formation (GO:0001841)	2.52315943
86	retinal cone cell development (GO:0046549)	2.49776850
87	histone H2A acetylation (GO:0043968)	2.49039194
88	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.48063170
89	photoreceptor cell maintenance (GO:0045494)	2.47038043
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.46364137
91	termination of RNA polymerase III transcription (GO:0006386)	2.46364137
92	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.45470714
93	isotype switching (GO:0045190)	2.45470714
94	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.45470714
95	rRNA modification (GO:0000154)	2.45282333
96	chaperone-mediated protein transport (GO:0072321)	2.45177298
97	intracellular protein transmembrane import (GO:0044743)	2.44000084
98	cilium morphogenesis (GO:0060271)	2.41920354
99	regulation of telomere maintenance (GO:0032204)	2.41876264
100	negative regulation of DNA recombination (GO:0045910)	2.41860078

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69394307
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.28594689
3	VDR_22108803_ChIP-Seq_LS180_Human	3.00699929
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.91914143
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85388330
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75561781
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.70043673
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.67863248
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46736856
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42663598
11	EWS_26573619_Chip-Seq_HEK293_Human	2.39094592
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35668267
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.31738117
14	FUS_26573619_Chip-Seq_HEK293_Human	2.30969360
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23852463
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06815091
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.05685997
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05452665
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95699748
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95508865
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94624649
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.94047743
23	P300_19829295_ChIP-Seq_ESCs_Human	1.88833378
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.82425916
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82325567
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81744411
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.79289270
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79029065
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.78679681
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.78637548
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.68808781
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64995685
33	E2F7_22180533_ChIP-Seq_HELA_Human	1.63087403
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57371013
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55652564
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.55640648
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55373787
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54157086
39	EZH2_22144423_ChIP-Seq_EOC_Human	1.50776058
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48995571
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48990959
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48515325
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.45484279
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44695498
45	* TP53_22573176_ChIP-Seq_HFKS_Human	1.42844708
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42394036
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.41752079
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39708406
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39617703
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30443506
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.29163024
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29163024
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28257570
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27053631
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27053631
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25105150
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22822654
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.21260826
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20807149
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20079964
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.20049781
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19486108
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18526771
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17955627
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17891821
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16169395
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15950931
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15496611
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15496611
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15398636
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14982292
72	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.14936413
73	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13312630
74	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13312630
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12237322
76	STAT3_23295773_ChIP-Seq_U87_Human	1.11498830
77	AR_25329375_ChIP-Seq_VCAP_Human	1.10552106
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10527577
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07602476
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06999308
81	TCF4_23295773_ChIP-Seq_U87_Human	1.06941596
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06740483
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06403208
84	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05257216
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.04552690
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03919993
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03622207
88	AR_20517297_ChIP-Seq_VCAP_Human	1.03080702
89	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01997684
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01763421
91	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00147035
92	NCOR_22424771_ChIP-Seq_293T_Human	0.97528461
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96943037
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95827038
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95194719
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94728688
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94638513
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93577650
99	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.92318440
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.91977283

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.37744336
2	MP0002102_abnormal_ear_morphology	2.53575742
3	MP0008058_abnormal_DNA_repair	2.45664521
4	MP0006292_abnormal_olfactory_placode	2.42698277
5	MP0003787_abnormal_imprinting	2.15760733
6	MP0002938_white_spotting	2.12733960
7	MP0001529_abnormal_vocalization	2.10595112
8	MP0004133_heterotaxia	2.09053870
9	MP0006072_abnormal_retinal_apoptosis	2.07901044
10	MP0003195_calcinosis	2.04452085
11	MP0002736_abnormal_nociception_after	2.02944878
12	MP0005551_abnormal_eye_electrophysiolog	2.00784576
13	MP0002837_dystrophic_cardiac_calcinosis	1.97889965
14	MP0003880_abnormal_central_pattern	1.97718374
15	MP0001968_abnormal_touch/_nociception	1.93073703
16	MP0008057_abnormal_DNA_replication	1.85892506
17	MP0010094_abnormal_chromosome_stability	1.83685338
18	MP0003890_abnormal_embryonic-extraembry	1.80821157
19	MP0005253_abnormal_eye_physiology	1.78809703
20	MP0002638_abnormal_pupillary_reflex	1.78655983
21	MP0001485_abnormal_pinna_reflex	1.77386612
22	MP0001986_abnormal_taste_sensitivity	1.75014681
23	MP0002653_abnormal_ependyma_morphology	1.69244706
24	MP0009046_muscle_twitch	1.68942240
25	MP0004147_increased_porphyrin_level	1.66056170
26	MP0004142_abnormal_muscle_tone	1.65880500
27	MP0006276_abnormal_autonomic_nervous	1.65069971
28	MP0003122_maternal_imprinting	1.63925654
29	MP0003121_genomic_imprinting	1.62052419
30	MP0003718_maternal_effect	1.59447597
31	MP0005645_abnormal_hypothalamus_physiol	1.57836600
32	MP0003136_yellow_coat_color	1.54560807
33	MP0003646_muscle_fatigue	1.53098344
34	MP0002751_abnormal_autonomic_nervous	1.48671843
35	MP0000372_irregular_coat_pigmentation	1.46622549
36	MP0009745_abnormal_behavioral_response	1.45982387
37	MP0000631_abnormal_neuroendocrine_gland	1.43199116
38	MP0008789_abnormal_olfactory_epithelium	1.42245418
39	MP0002272_abnormal_nervous_system	1.39346739
40	MP0008995_early_reproductive_senescence	1.38758764
41	MP0005646_abnormal_pituitary_gland	1.34508989
42	MP0001293_anophthalmia	1.33331028
43	MP0003786_premature_aging	1.32841533
44	MP0008872_abnormal_physiological_respon	1.31877697
45	MP0001984_abnormal_olfaction	1.31756846
46	MP0003119_abnormal_digestive_system	1.31197390
47	MP0001486_abnormal_startle_reflex	1.29835579
48	MP0003693_abnormal_embryo_hatching	1.25517201
49	MP0005084_abnormal_gallbladder_morpholo	1.25305937
50	MP0008875_abnormal_xenobiotic_pharmacok	1.23660434
51	MP0002234_abnormal_pharynx_morphology	1.22880763
52	MP0000778_abnormal_nervous_system	1.21861081
53	MP0003011_delayed_dark_adaptation	1.18896477
54	MP0004742_abnormal_vestibular_system	1.16461561
55	MP0000427_abnormal_hair_cycle	1.15173893
56	MP0000569_abnormal_digit_pigmentation	1.14473948
57	MP0002160_abnormal_reproductive_system	1.14381068
58	MP0004043_abnormal_pH_regulation	1.13598181
59	MP0005499_abnormal_olfactory_system	1.10272747
60	MP0005394_taste/olfaction_phenotype	1.10272747
61	MP0003937_abnormal_limbs/digits/tail_de	1.09682570
62	MP0003283_abnormal_digestive_organ	1.05993341
63	MP0002210_abnormal_sex_determination	1.04486314
64	MP0002557_abnormal_social/conspecific_i	1.04145457
65	MP0004145_abnormal_muscle_electrophysio	1.02842391
66	MP0001929_abnormal_gametogenesis	1.02314182
67	MP0004885_abnormal_endolymph	1.00806502
68	MP0006035_abnormal_mitochondrial_morpho	0.99621596
69	MP0002572_abnormal_emotion/affect_behav	0.99267677
70	MP0002735_abnormal_chemical_nociception	0.99115520
71	MP0002067_abnormal_sensory_capabilities	0.98270385
72	MP0003878_abnormal_ear_physiology	0.96746426
73	MP0005377_hearing/vestibular/ear_phenot	0.96746426
74	MP0005389_reproductive_system_phenotype	0.96120486
75	MP0004924_abnormal_behavior	0.95844786
76	MP0005386_behavior/neurological_phenoty	0.95844786
77	MP0002876_abnormal_thyroid_physiology	0.95050965
78	MP0003698_abnormal_male_reproductive	0.93163833
79	MP0001188_hyperpigmentation	0.91234584
80	MP0005195_abnormal_posterior_eye	0.91157706
81	MP0002277_abnormal_respiratory_mucosa	0.90998543
82	MP0002064_seizures	0.89355934
83	MP0002734_abnormal_mechanical_nocicepti	0.89140956
84	MP0002752_abnormal_somatic_nervous	0.88995952
85	MP0005423_abnormal_somatic_nervous	0.88892518
86	MP0004215_abnormal_myocardial_fiber	0.88665431
87	MP0001501_abnormal_sleep_pattern	0.88596579
88	MP0005391_vision/eye_phenotype	0.88524912
89	MP0001764_abnormal_homeostasis	0.88008586
90	MP0000653_abnormal_sex_gland	0.87573197
91	MP0002184_abnormal_innervation	0.84754141
92	MP0001145_abnormal_male_reproductive	0.84746132
93	MP0002928_abnormal_bile_duct	0.84076097
94	MP0003111_abnormal_nucleus_morphology	0.83336659
95	MP0008932_abnormal_embryonic_tissue	0.82725287
96	MP0000049_abnormal_middle_ear	0.81833273
97	MP0000647_abnormal_sebaceous_gland	0.81561936
98	MP0002095_abnormal_skin_pigmentation	0.80475845
99	MP0008007_abnormal_cellular_replicative	0.79124595
100	MP0002733_abnormal_thermal_nociception	0.77844439

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.06342421
2	Pancreatic fibrosis (HP:0100732)	3.80043366
3	True hermaphroditism (HP:0010459)	3.78874457
4	Molar tooth sign on MRI (HP:0002419)	3.52411684
5	Abnormality of midbrain morphology (HP:0002418)	3.52411684
6	Type II lissencephaly (HP:0007260)	3.39088883
7	Abnormality of the labia minora (HP:0012880)	3.25803741
8	Nephronophthisis (HP:0000090)	3.11775360
9	Congenital stationary night blindness (HP:0007642)	3.02681572
10	Medial flaring of the eyebrow (HP:0010747)	2.94894584
11	Abnormality of the renal medulla (HP:0100957)	2.65201209
12	Acute necrotizing encephalopathy (HP:0006965)	2.64082454
13	Cerebellar dysplasia (HP:0007033)	2.60611981
14	Increased CSF lactate (HP:0002490)	2.57565526
15	Lipid accumulation in hepatocytes (HP:0006561)	2.57179007
16	Increased hepatocellular lipid droplets (HP:0006565)	2.52270831
17	Pendular nystagmus (HP:0012043)	2.52118644
18	Abnormality of the renal cortex (HP:0011035)	2.51338460
19	Mitochondrial inheritance (HP:0001427)	2.50536741
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.48443314
21	Intestinal atresia (HP:0011100)	2.47907575
22	Hypoplasia of the pons (HP:0012110)	2.45418245
23	Abnormality of the pons (HP:0007361)	2.44797775
24	Acute encephalopathy (HP:0006846)	2.41054661
25	Cystic liver disease (HP:0006706)	2.40224623
26	Abnormality of the ileum (HP:0001549)	2.39986270
27	Gait imbalance (HP:0002141)	2.37546098
28	Congenital primary aphakia (HP:0007707)	2.37348705
29	Meckel diverticulum (HP:0002245)	2.36514043
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35639671
31	Abnormality of alanine metabolism (HP:0010916)	2.35639671
32	Hyperalaninemia (HP:0003348)	2.35639671
33	Lissencephaly (HP:0001339)	2.35418118
34	Retinal dysplasia (HP:0007973)	2.33375687
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32925789
36	Progressive macrocephaly (HP:0004481)	2.32724806
37	Sclerocornea (HP:0000647)	2.31397338
38	Abolished electroretinogram (ERG) (HP:0000550)	2.29390762
39	Chronic hepatic failure (HP:0100626)	2.26095112
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.26059462
41	3-Methylglutaconic aciduria (HP:0003535)	2.25070886
42	Colon cancer (HP:0003003)	2.20009850
43	Genital tract atresia (HP:0001827)	2.19279369
44	Nephrogenic diabetes insipidus (HP:0009806)	2.18941291
45	Bilateral microphthalmos (HP:0007633)	2.17732086
46	Anencephaly (HP:0002323)	2.17641233
47	Hyperventilation (HP:0002883)	2.16526809
48	Vaginal atresia (HP:0000148)	2.16048592
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.15530792
50	Methylmalonic acidemia (HP:0002912)	2.15363812
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12370634
52	Abnormal biliary tract physiology (HP:0012439)	2.12034176
53	Bile duct proliferation (HP:0001408)	2.12034176
54	Optic nerve hypoplasia (HP:0000609)	2.10030322
55	Hepatocellular necrosis (HP:0001404)	2.08933615
56	Postaxial foot polydactyly (HP:0001830)	2.05086478
57	Optic disc pallor (HP:0000543)	2.04542185
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04065563
59	Attenuation of retinal blood vessels (HP:0007843)	2.03307547
60	Abnormality of chromosome stability (HP:0003220)	2.03148165
61	Methylmalonic aciduria (HP:0012120)	2.02770050
62	Progressive inability to walk (HP:0002505)	2.00382443
63	Renal cortical cysts (HP:0000803)	1.98487403
64	Septo-optic dysplasia (HP:0100842)	1.98255160
65	Birth length less than 3rd percentile (HP:0003561)	1.97287026
66	Preaxial hand polydactyly (HP:0001177)	1.96405835
67	Inability to walk (HP:0002540)	1.95401439
68	Male pseudohermaphroditism (HP:0000037)	1.95173247
69	Chromsome breakage (HP:0040012)	1.95077281
70	Hepatic necrosis (HP:0002605)	1.94106058
71	Sloping forehead (HP:0000340)	1.94057848
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93889998
73	Dandy-Walker malformation (HP:0001305)	1.93617525
74	Tubular atrophy (HP:0000092)	1.91808963
75	Patellar aplasia (HP:0006443)	1.89756107
76	Congenital hepatic fibrosis (HP:0002612)	1.87697518
77	Increased serum lactate (HP:0002151)	1.87199546
78	Abnormality of the preputium (HP:0100587)	1.86867206
79	Broad-based gait (HP:0002136)	1.84875471
80	Abnormal rod and cone electroretinograms (HP:0008323)	1.84492890
81	Polydipsia (HP:0001959)	1.80305644
82	Abnormal drinking behavior (HP:0030082)	1.80305644
83	Oligodactyly (hands) (HP:0001180)	1.80276898
84	Hyperglycinemia (HP:0002154)	1.80147054
85	Short tibia (HP:0005736)	1.79803263
86	Astigmatism (HP:0000483)	1.78693424
87	Volvulus (HP:0002580)	1.77635288
88	Hypothermia (HP:0002045)	1.77348015
89	Furrowed tongue (HP:0000221)	1.77089648
90	Supernumerary spleens (HP:0009799)	1.75701734
91	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74760835
92	Postaxial hand polydactyly (HP:0001162)	1.74146757
93	Renal Fanconi syndrome (HP:0001994)	1.73867596
94	Triphalangeal thumb (HP:0001199)	1.73090493
95	Poor coordination (HP:0002370)	1.72613242
96	Abnormality of the duodenum (HP:0002246)	1.71803541
97	Anophthalmia (HP:0000528)	1.70871691
98	Gaze-evoked nystagmus (HP:0000640)	1.70869333
99	Occipital encephalocele (HP:0002085)	1.70532950
100	Gastrointestinal atresia (HP:0002589)	1.69028377

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.10126291
2	WNK3	3.66024258
3	ZAK	3.29521255
4	MAP4K2	2.94566672
5	BMPR1B	2.54988632
6	NUAK1	2.42133445
7	ADRBK2	2.24543463
8	MKNK2	2.07776272
9	CASK	2.03468235
10	TLK1	1.93574195
11	TRIM28	1.88224596
12	MAP3K4	1.84657850
13	TNIK	1.83126288
14	SRPK1	1.74349902
15	PNCK	1.58066812
16	ACVR1B	1.57172256
17	MKNK1	1.55748589
18	VRK2	1.55477049
19	GRK1	1.54356451
20	DYRK2	1.50558079
21	PLK3	1.50546915
22	VRK1	1.47857228
23	CDC7	1.46494369
24	BUB1	1.43631412
25	INSRR	1.41465729
26	MAPK13	1.41202386
27	BRSK2	1.38675940
28	TSSK6	1.37369372
29	TXK	1.36880390
30	EPHA3	1.33960852
31	BCR	1.29734298
32	EIF2AK3	1.29169362
33	WEE1	1.28861057
34	STK38L	1.26544726
35	MAP2K7	1.25911537
36	MST4	1.16128798
37	BCKDK	1.15183764
38	PINK1	1.15167323
39	WNK4	1.15126342
40	PLK4	1.14596127
41	DYRK3	1.07736027
42	STK16	1.04364835
43	OXSR1	1.02149657
44	MARK1	1.01948263
45	CSNK1G3	0.99822681
46	CSNK1G2	0.99771716
47	CSNK1G1	0.97262998
48	PLK1	0.95178601
49	DAPK2	0.92746050
50	TAF1	0.92261725
51	PAK3	0.91170984
52	NME1	0.91160148
53	TTK	0.88876135
54	TGFBR1	0.88587895
55	PRKCG	0.86556204
56	ATR	0.85170589
57	PLK2	0.83314666
58	CSNK1A1L	0.83137168
59	PRKCE	0.81671486
60	ERBB3	0.80725168
61	TAOK3	0.79936494
62	EPHA4	0.78657024
63	EIF2AK1	0.77617323
64	PASK	0.77053064
65	SIK2	0.74123816
66	NEK2	0.73788372
67	NEK1	0.72369831
68	CHEK2	0.71182945
69	STK39	0.69032007
70	PBK	0.68484069
71	RPS6KA5	0.67230932
72	RPS6KA4	0.65691449
73	NLK	0.65544657
74	ADRBK1	0.64679304
75	FGFR2	0.63388387
76	BRD4	0.61745460
77	ATM	0.57701427
78	TIE1	0.56324982
79	IRAK1	0.50341923
80	PKN1	0.46762094
81	MUSK	0.46182353
82	MINK1	0.43700053
83	CSNK1A1	0.43330786
84	NTRK2	0.40811831
85	CAMK2A	0.40549076
86	FER	0.40403493
87	BRSK1	0.37212545
88	CSNK2A1	0.36590229
89	STK3	0.35674079
90	NTRK3	0.35310820
91	MARK3	0.35292439
92	EIF2AK2	0.35278462
93	CSNK1D	0.34618303
94	CDK19	0.33878178
95	AURKB	0.33021359
96	PHKG1	0.32550434
97	PHKG2	0.32550434
98	CSNK1E	0.32506835
99	PRKACA	0.32422791
100	PRKCI	0.31640640

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.80722085
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.66342625
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56978149
4	RNA polymerase_Homo sapiens_hsa03020	2.45732861
5	Protein export_Homo sapiens_hsa03060	2.44623632
6	Proteasome_Homo sapiens_hsa03050	2.36636820
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30017483
8	Basal transcription factors_Homo sapiens_hsa03022	2.24182168
9	Mismatch repair_Homo sapiens_hsa03430	2.18281020
10	Parkinsons disease_Homo sapiens_hsa05012	2.18211235
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12403438
12	Phototransduction_Homo sapiens_hsa04744	2.12038579
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.11673558
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01235945
15	Butanoate metabolism_Homo sapiens_hsa00650	1.93251015
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86571726
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.82136043
18	RNA degradation_Homo sapiens_hsa03018	1.81248848
19	DNA replication_Homo sapiens_hsa03030	1.80902669
20	Propanoate metabolism_Homo sapiens_hsa00640	1.73828381
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70059409
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68810589
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63527306
24	Huntingtons disease_Homo sapiens_hsa05016	1.62753911
25	One carbon pool by folate_Homo sapiens_hsa00670	1.61064500
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60708882
27	Nicotine addiction_Homo sapiens_hsa05033	1.60304936
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57657445
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.54382490
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.49414140
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.40409288
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39924119
33	Base excision repair_Homo sapiens_hsa03410	1.37208163
34	RNA transport_Homo sapiens_hsa03013	1.36035454
35	Caffeine metabolism_Homo sapiens_hsa00232	1.29645452
36	Spliceosome_Homo sapiens_hsa03040	1.27188329
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25060523
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23701254
39	Alzheimers disease_Homo sapiens_hsa05010	1.20237079
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.19162093
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18945969
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.16821061
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.11837069
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.11825575
45	Peroxisome_Homo sapiens_hsa04146	1.10623736
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09057816
47	Ribosome_Homo sapiens_hsa03010	1.08385250
48	Taste transduction_Homo sapiens_hsa04742	1.07832466
49	Purine metabolism_Homo sapiens_hsa00230	1.06737073
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06591329
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05717314
52	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03820738
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03103115
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93682190
55	Fatty acid elongation_Homo sapiens_hsa00062	0.85931789
56	Olfactory transduction_Homo sapiens_hsa04740	0.80191560
57	Regulation of autophagy_Homo sapiens_hsa04140	0.78429383
58	GABAergic synapse_Homo sapiens_hsa04727	0.76877077
59	Cell cycle_Homo sapiens_hsa04110	0.75020907
60	Metabolic pathways_Homo sapiens_hsa01100	0.74957572
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74726726
62	Morphine addiction_Homo sapiens_hsa05032	0.70326488
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69807413
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65256581
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65169292
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63854911
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63292004
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.62266353
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60900308
70	Folate biosynthesis_Homo sapiens_hsa00790	0.60842988
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60618989
72	Retinol metabolism_Homo sapiens_hsa00830	0.59352764
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57674456
74	Circadian rhythm_Homo sapiens_hsa04710	0.56995810
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56541770
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56307328
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55926913
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53192909
79	Serotonergic synapse_Homo sapiens_hsa04726	0.52928689
80	Sulfur relay system_Homo sapiens_hsa04122	0.52734451
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52032846
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51154846
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50539757
84	Insulin secretion_Homo sapiens_hsa04911	0.50485015
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.50147530
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49259586
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.48050414
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47232725
89	Oocyte meiosis_Homo sapiens_hsa04114	0.46571169
90	Glutathione metabolism_Homo sapiens_hsa00480	0.45672341
91	Circadian entrainment_Homo sapiens_hsa04713	0.44953558
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43973034
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.43805305
94	Fatty acid degradation_Homo sapiens_hsa00071	0.43693583
95	Sulfur metabolism_Homo sapiens_hsa00920	0.42421856
96	p53 signaling pathway_Homo sapiens_hsa04115	0.41350292
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40911444
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38360946
99	ABC transporters_Homo sapiens_hsa02010	0.34591315
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.33758803

ZNF620

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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