ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	monoubiquitinated protein deubiquitination (GO:0035520)	4.39118152
2	protein K11-linked deubiquitination (GO:0035871)	4.14005705
3	interkinetic nuclear migration (GO:0022027)	3.86256020
4	regulation of hippo signaling (GO:0035330)	3.67647557
5	positive regulation of developmental pigmentation (GO:0048087)	3.66188468
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.42521783
7	regulation of translation, ncRNA-mediated (GO:0045974)	3.42521783
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.42521783
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.38880401
10	establishment of protein localization to Golgi (GO:0072600)	3.36472039
11	neural tube formation (GO:0001841)	3.34724234
12	regulation of pigment cell differentiation (GO:0050932)	3.26384551
13	protein prenylation (GO:0018342)	3.25223549
14	prenylation (GO:0097354)	3.25223549
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24518056
16	histone H3-K4 trimethylation (GO:0080182)	3.22558548
17	behavioral response to nicotine (GO:0035095)	3.16748242
18	protein K48-linked deubiquitination (GO:0071108)	3.16244923
19	microtubule anchoring (GO:0034453)	3.15033910
20	indolalkylamine metabolic process (GO:0006586)	3.13945073
21	indole-containing compound catabolic process (GO:0042436)	3.10555366
22	indolalkylamine catabolic process (GO:0046218)	3.10555366
23	tryptophan catabolic process (GO:0006569)	3.10555366
24	histone H3-K9 methylation (GO:0051567)	3.09602083
25	regulation of sarcomere organization (GO:0060297)	3.07518736
26	snRNA transcription (GO:0009301)	3.02745735
27	kynurenine metabolic process (GO:0070189)	3.01646797
28	appendage development (GO:0048736)	3.01149165
29	limb development (GO:0060173)	3.01149165
30	cilium morphogenesis (GO:0060271)	2.98798651
31	signal peptide processing (GO:0006465)	2.96320983
32	cilium or flagellum-dependent cell motility (GO:0001539)	2.95126654
33	cellular response to sterol (GO:0036315)	2.92110233
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.83397281
35	L-fucose metabolic process (GO:0042354)	2.81373712
36	L-fucose catabolic process (GO:0042355)	2.81373712
37	fucose catabolic process (GO:0019317)	2.81373712
38	peptidyl-lysine trimethylation (GO:0018023)	2.79741147
39	cilium organization (GO:0044782)	2.79360208
40	cilium assembly (GO:0042384)	2.78760851
41	regulation of establishment of cell polarity (GO:2000114)	2.78099159
42	nucleus localization (GO:0051647)	2.73912352
43	cornea development in camera-type eye (GO:0061303)	2.71743184
44	auditory receptor cell differentiation (GO:0042491)	2.71321151
45	peptidyl-lysine methylation (GO:0018022)	2.71130022
46	pericardium development (GO:0060039)	2.70800437
47	nonmotile primary cilium assembly (GO:0035058)	2.68981826
48	detection of light stimulus involved in sensory perception (GO:0050962)	2.68838889
49	detection of light stimulus involved in visual perception (GO:0050908)	2.68838889
50	cellular response to ethanol (GO:0071361)	2.68282329
51	regulation of DNA endoreduplication (GO:0032875)	2.68181930
52	photoreceptor cell maintenance (GO:0045494)	2.67587063
53	replication fork processing (GO:0031297)	2.66983588
54	histone H3-K9 modification (GO:0061647)	2.66094725
55	cytoplasmic mRNA processing body assembly (GO:0033962)	2.64932449
56	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.64574060
57	reflex (GO:0060004)	2.62736869
58	meiotic chromosome segregation (GO:0045132)	2.60339779
59	protein targeting to Golgi (GO:0000042)	2.58317732
60	behavioral response to ethanol (GO:0048149)	2.57745107
61	tryptophan metabolic process (GO:0006568)	2.57585920
62	presynaptic membrane assembly (GO:0097105)	2.57505287
63	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.54342009
64	photoreceptor cell development (GO:0042461)	2.52812820
65	negative regulation of systemic arterial blood pressure (GO:0003085)	2.51190334
66	cAMP catabolic process (GO:0006198)	2.49975730
67	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.49606738
68	cyclic nucleotide catabolic process (GO:0009214)	2.49148186
69	double-strand break repair via homologous recombination (GO:0000724)	2.48684979
70	dorsal/ventral axis specification (GO:0009950)	2.48317266
71	protein targeting to vacuole (GO:0006623)	2.47462787
72	protein targeting to lysosome (GO:0006622)	2.47462787
73	establishment of protein localization to vacuole (GO:0072666)	2.47462787
74	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.45872636
75	response to pheromone (GO:0019236)	2.44603006
76	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.44531659
77	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.42950685
78	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.42639710
79	recombinational repair (GO:0000725)	2.42632327
80	inner ear receptor stereocilium organization (GO:0060122)	2.41766000
81	regulation of gene silencing by RNA (GO:0060966)	2.41347831
82	regulation of posttranscriptional gene silencing (GO:0060147)	2.41347831
83	regulation of gene silencing by miRNA (GO:0060964)	2.41347831
84	acrosome assembly (GO:0001675)	2.39815432
85	startle response (GO:0001964)	2.39383462
86	phospholipid translocation (GO:0045332)	2.38158688
87	lipid translocation (GO:0034204)	2.38158688
88	rRNA catabolic process (GO:0016075)	2.38151360
89	central nervous system neuron axonogenesis (GO:0021955)	2.35979215
90	eye photoreceptor cell development (GO:0042462)	2.35844124
91	hindbrain development (GO:0030902)	2.35524692
92	epithelial cilium movement (GO:0003351)	2.35227870
93	negative regulation of neurotransmitter transport (GO:0051589)	2.34955015
94	protein K63-linked deubiquitination (GO:0070536)	2.34918411
95	intraciliary transport (GO:0042073)	2.34099504
96	central nervous system myelination (GO:0022010)	2.33344000
97	axon ensheathment in central nervous system (GO:0032291)	2.33344000
98	histone lysine methylation (GO:0034968)	2.33186377
99	reciprocal DNA recombination (GO:0035825)	2.32265683
100	reciprocal meiotic recombination (GO:0007131)	2.32265683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.28955986
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.18994880
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.11038247
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.99813950
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94082302
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76953488
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70274513
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55234295
9	VDR_22108803_ChIP-Seq_LS180_Human	2.47895077
10	FUS_26573619_Chip-Seq_HEK293_Human	2.30768016
11	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.26433104
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.25177014
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.24096920
14	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.23456697
15	EWS_26573619_Chip-Seq_HEK293_Human	2.20020272
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18013544
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.11088524
18	P300_19829295_ChIP-Seq_ESCs_Human	2.04757733
19	STAT3_23295773_ChIP-Seq_U87_Human	1.99637323
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92637966
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.92419553
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.92030726
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.91723526
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81357697
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75526496
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.74497472
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.73973173
28	TCF4_23295773_ChIP-Seq_U87_Human	1.73384355
29	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.71992784
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.71103043
31	TP53_16413492_ChIP-PET_HCT116_Human	1.67194325
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63835971
33	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.62595994
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59859372
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.58875054
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55707261
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55707261
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55258215
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55170688
40	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54542471
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52540295
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.52509776
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50768169
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.50768169
45	AR_25329375_ChIP-Seq_VCAP_Human	1.49695611
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43782296
47	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43640028
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41880217
49	AHR_22903824_ChIP-Seq_MCF-7_Human	1.41584826
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39551288
51	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.37805125
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37628542
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.37416774
54	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.35955797
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.35048720
56	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32621343
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31701749
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.31688548
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31334034
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30611719
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29709107
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29463208
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29301573
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28072648
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21680073
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.20220682
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.20100878
68	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19709999
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.19475101
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18814674
71	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17722760
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17696770
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.17527050
74	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.17394032
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16636989
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15775188
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14956867
78	RXR_22108803_ChIP-Seq_LS180_Human	1.14515679
79	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.14347346
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14051820
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.13247460
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11735286
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11220694
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.10360680
85	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.10360680
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09590182
87	KDM2B_26808549_Chip-Seq_REH_Human	1.08622587
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08213664
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.06222867
90	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05377083
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05135212
92	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.04962706
93	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.04605653
94	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04417471
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04296086
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02918328
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.02474735
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02179577
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01891641
100	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.01668748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.80579025
2	MP0008057_abnormal_DNA_replication	3.26420207
3	MP0003195_calcinosis	2.47397106
4	MP0003136_yellow_coat_color	2.37301653
5	MP0008877_abnormal_DNA_methylation	2.20493048
6	MP0005551_abnormal_eye_electrophysiolog	2.17115459
7	MP0003787_abnormal_imprinting	2.08672832
8	MP0002938_white_spotting	2.06726704
9	MP0000427_abnormal_hair_cycle	2.02797736
10	MP0003646_muscle_fatigue	2.02184879
11	MP0003890_abnormal_embryonic-extraembry	1.97517516
12	MP0006292_abnormal_olfactory_placode	1.92656447
13	MP0000383_abnormal_hair_follicle	1.87951673
14	MP0004043_abnormal_pH_regulation	1.83247929
15	MP0003950_abnormal_plasma_membrane	1.73422040
16	MP0005646_abnormal_pituitary_gland	1.72702368
17	MP0009046_muscle_twitch	1.70735491
18	MP0003937_abnormal_limbs/digits/tail_de	1.70322248
19	MP0005253_abnormal_eye_physiology	1.69626824
20	MP0000631_abnormal_neuroendocrine_gland	1.69444533
21	MP0005174_abnormal_tail_pigmentation	1.68959904
22	MP0001501_abnormal_sleep_pattern	1.59527974
23	MP0005171_absent_coat_pigmentation	1.57748169
24	MP0002102_abnormal_ear_morphology	1.55039229
25	MP0000778_abnormal_nervous_system	1.53273279
26	MP0002876_abnormal_thyroid_physiology	1.44908486
27	MP0000372_irregular_coat_pigmentation	1.41019926
28	MP0003943_abnormal_hepatobiliary_system	1.40203632
29	MP0004133_heterotaxia	1.34992853
30	MP0001486_abnormal_startle_reflex	1.33869465
31	MP0000647_abnormal_sebaceous_gland	1.31829467
32	MP0006072_abnormal_retinal_apoptosis	1.30620378
33	MP0002928_abnormal_bile_duct	1.30194829
34	MP0002009_preneoplasia	1.23173078
35	MP0005187_abnormal_penis_morphology	1.23144134
36	MP0001324_abnormal_eye_pigmentation	1.22596779
37	MP0002557_abnormal_social/conspecific_i	1.22509092
38	MP0002095_abnormal_skin_pigmentation	1.21941005
39	MP0002638_abnormal_pupillary_reflex	1.20872927
40	MP0010678_abnormal_skin_adnexa	1.18919864
41	MP0003045_fibrosis	1.18388347
42	MP0002837_dystrophic_cardiac_calcinosis	1.17818870
43	MP0004142_abnormal_muscle_tone	1.16125540
44	MP0003755_abnormal_palate_morphology	1.15195547
45	MP0001984_abnormal_olfaction	1.14369929
46	MP0004885_abnormal_endolymph	1.14304065
47	MP0002168_other_aberrant_phenotype	1.10555281
48	MP0002234_abnormal_pharynx_morphology	1.08983200
49	MP0000371_diluted_coat_color	1.07868116
50	MP0002653_abnormal_ependyma_morphology	1.07585586
51	MP0005391_vision/eye_phenotype	1.07451143
52	MP0001299_abnormal_eye_distance/	1.06588639
53	MP0001485_abnormal_pinna_reflex	1.06482044
54	MP0006276_abnormal_autonomic_nervous	1.05714805
55	MP0003935_abnormal_craniofacial_develop	1.04568029
56	MP0002160_abnormal_reproductive_system	1.04099338
57	MP0009745_abnormal_behavioral_response	1.03733968
58	MP0005386_behavior/neurological_phenoty	1.00371077
59	MP0004924_abnormal_behavior	1.00371077
60	MP0008775_abnormal_heart_ventricle	0.99533332
61	MP0003121_genomic_imprinting	0.98937886
62	MP0005195_abnormal_posterior_eye	0.96659250
63	MP0000955_abnormal_spinal_cord	0.96371161
64	MP0002272_abnormal_nervous_system	0.95947001
65	MP0001968_abnormal_touch/_nociception	0.95358504
66	MP0010094_abnormal_chromosome_stability	0.95293616
67	MP0004147_increased_porphyrin_level	0.93249431
68	MP0006054_spinal_hemorrhage	0.93143959
69	MP0002752_abnormal_somatic_nervous	0.92257826
70	MP0003567_abnormal_fetal_cardiomyocyte	0.91866596
71	MP0002572_abnormal_emotion/affect_behav	0.91333150
72	MP0002751_abnormal_autonomic_nervous	0.90347637
73	MP0002109_abnormal_limb_morphology	0.89788591
74	MP0002184_abnormal_innervation	0.87950404
75	MP0005389_reproductive_system_phenotype	0.87288049
76	MP0004215_abnormal_myocardial_fiber	0.87230692
77	MP0001293_anophthalmia	0.86086854
78	MP0000015_abnormal_ear_pigmentation	0.86013141
79	MP0004085_abnormal_heartbeat	0.85209747
80	MP0000428_abnormal_craniofacial_morphol	0.85062712
81	MP0008961_abnormal_basal_metabolism	0.84897350
82	MP0001286_abnormal_eye_development	0.84652033
83	MP0003119_abnormal_digestive_system	0.84369355
84	MP0003861_abnormal_nervous_system	0.84185966
85	MP0002736_abnormal_nociception_after	0.83416268
86	MP0001919_abnormal_reproductive_system	0.82264313
87	MP0002067_abnormal_sensory_capabilities	0.82179457
88	MP0008872_abnormal_physiological_respon	0.81700785
89	MP0004145_abnormal_muscle_electrophysio	0.81574198
90	MP0008058_abnormal_DNA_repair	0.80186885
91	MP0002233_abnormal_nose_morphology	0.79515649
92	MP0004742_abnormal_vestibular_system	0.79176563
93	MP0001986_abnormal_taste_sensitivity	0.78865889
94	MP0002152_abnormal_brain_morphology	0.77228930
95	MP0002064_seizures	0.77047153
96	MP0000432_abnormal_head_morphology	0.76293991
97	MP0002882_abnormal_neuron_morphology	0.76017433
98	MP0002063_abnormal_learning/memory/cond	0.75502869
99	MP0003632_abnormal_nervous_system	0.75389768
100	MP0005220_abnormal_exocrine_pancreas	0.74726931

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.45115073
2	Pancreatic fibrosis (HP:0100732)	4.40137585
3	Hyperventilation (HP:0002883)	4.11415551
4	True hermaphroditism (HP:0010459)	4.02042027
5	Molar tooth sign on MRI (HP:0002419)	3.72180706
6	Abnormality of midbrain morphology (HP:0002418)	3.72180706
7	Nephronophthisis (HP:0000090)	3.33047113
8	Genetic anticipation (HP:0003743)	3.19746387
9	Cystic liver disease (HP:0006706)	3.14415006
10	Abnormality of the renal medulla (HP:0100957)	3.13931925
11	Abnormality of the renal cortex (HP:0011035)	3.04437412
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.00290227
13	Chronic hepatic failure (HP:0100626)	2.94656138
14	Gaze-evoked nystagmus (HP:0000640)	2.92909619
15	Protruding tongue (HP:0010808)	2.84689809
16	Medial flaring of the eyebrow (HP:0010747)	2.70712980
17	Volvulus (HP:0002580)	2.65300253
18	Fair hair (HP:0002286)	2.63464147
19	Type II lissencephaly (HP:0007260)	2.63039049
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.56540782
21	Tubular atrophy (HP:0000092)	2.54415563
22	Intestinal atresia (HP:0011100)	2.53109984
23	Progressive cerebellar ataxia (HP:0002073)	2.46668124
24	Postaxial foot polydactyly (HP:0001830)	2.41750966
25	Congenital stationary night blindness (HP:0007642)	2.40024106
26	Absent speech (HP:0001344)	2.37744999
27	Abnormality of the ischium (HP:0003174)	2.34666336
28	Congenital primary aphakia (HP:0007707)	2.33547047
29	Cerebellar dysplasia (HP:0007033)	2.33343435
30	Gait imbalance (HP:0002141)	2.32032373
31	Broad-based gait (HP:0002136)	2.30194987
32	Keratoconus (HP:0000563)	2.28677530
33	Increased corneal curvature (HP:0100692)	2.28677530
34	Hypoplastic ischia (HP:0003175)	2.26627293
35	Congenital hepatic fibrosis (HP:0002612)	2.25493513
36	Nephrogenic diabetes insipidus (HP:0009806)	2.23376812
37	Attenuation of retinal blood vessels (HP:0007843)	2.22758647
38	Widely spaced teeth (HP:0000687)	2.20647740
39	Febrile seizures (HP:0002373)	2.20004553
40	Genital tract atresia (HP:0001827)	2.18198517
41	Poor coordination (HP:0002370)	2.17414724
42	Abnormal drinking behavior (HP:0030082)	2.16807146
43	Polydipsia (HP:0001959)	2.16807146
44	Drooling (HP:0002307)	2.14926383
45	Lissencephaly (HP:0001339)	2.10967053
46	Anencephaly (HP:0002323)	2.10795019
47	Furrowed tongue (HP:0000221)	2.10320739
48	Preaxial hand polydactyly (HP:0001177)	2.09325560
49	Short foot (HP:0001773)	2.08188032
50	Hypoplastic iliac wings (HP:0002866)	2.07350245
51	Highly arched eyebrow (HP:0002553)	2.06696452
52	Sclerocornea (HP:0000647)	2.04838811
53	Renal cortical cysts (HP:0000803)	2.04527837
54	Vaginal atresia (HP:0000148)	2.04042031
55	Progressive inability to walk (HP:0002505)	2.02990029
56	Clumsiness (HP:0002312)	2.00635582
57	Oligodactyly (hands) (HP:0001180)	2.00592123
58	Preaxial foot polydactyly (HP:0001841)	2.00167354
59	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.99036419
60	Large for gestational age (HP:0001520)	1.98048340
61	Generalized hypopigmentation of hair (HP:0011358)	1.97189927
62	Small hand (HP:0200055)	1.94803737
63	Sloping forehead (HP:0000340)	1.94186978
64	Postaxial hand polydactyly (HP:0001162)	1.93143991
65	Astigmatism (HP:0000483)	1.92692632
66	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92229576
67	Bifid tongue (HP:0010297)	1.92190952
68	Dandy-Walker malformation (HP:0001305)	1.91368343
69	Bile duct proliferation (HP:0001408)	1.90250219
70	Abnormal biliary tract physiology (HP:0012439)	1.90250219
71	Enlarged kidneys (HP:0000105)	1.89679798
72	Excessive salivation (HP:0003781)	1.86579673
73	Hypoplastic labia majora (HP:0000059)	1.86317502
74	Patellar aplasia (HP:0006443)	1.84983297
75	Tubulointerstitial nephritis (HP:0001970)	1.84186422
76	Narrow forehead (HP:0000341)	1.82614507
77	Fibular hypoplasia (HP:0003038)	1.81130460
78	Chorioretinal atrophy (HP:0000533)	1.80233193
79	Prominent nasal bridge (HP:0000426)	1.78575072
80	Hemiparesis (HP:0001269)	1.78425021
81	Inability to walk (HP:0002540)	1.77957481
82	Abnormality of chromosome stability (HP:0003220)	1.77631235
83	Male pseudohermaphroditism (HP:0000037)	1.77610586
84	Abolished electroretinogram (ERG) (HP:0000550)	1.77566976
85	Dialeptic seizures (HP:0011146)	1.75225202
86	Gastrointestinal atresia (HP:0002589)	1.75136042
87	Short tibia (HP:0005736)	1.74786520
88	Focal seizures (HP:0007359)	1.74113848
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.72455699
90	Abnormality of the nasal septum (HP:0000419)	1.70101653
91	Aqueductal stenosis (HP:0002410)	1.68911823
92	Aplasia/Hypoplasia of the patella (HP:0006498)	1.68643922
93	Chromsome breakage (HP:0040012)	1.68385378
94	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.67019913
95	Blue irides (HP:0000635)	1.66651156
96	Abnormality of the ileum (HP:0001549)	1.65917075
97	Oculomotor apraxia (HP:0000657)	1.65736860
98	Abnormality of the pons (HP:0007361)	1.65690895
99	Bulbous nose (HP:0000414)	1.65503713
100	Tented upper lip vermilion (HP:0010804)	1.65387619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.45828308
2	BMPR1B	2.96088284
3	CASK	2.61640855
4	ACVR1B	2.39809166
5	MKNK2	2.31221548
6	AKT3	2.13858522
7	BRD4	2.02627039
8	BRSK2	1.96088321
9	LATS1	1.92079874
10	WNK3	1.87103465
11	ADRBK2	1.86096217
12	STK38L	1.80623163
13	MAPK13	1.79336878
14	PNCK	1.73504319
15	MAP4K2	1.72805701
16	NUAK1	1.66475263
17	STK39	1.66068599
18	NTRK3	1.54193973
19	TNIK	1.49551121
20	CAMK1G	1.45294528
21	WNK4	1.44929313
22	MAP3K4	1.31101216
23	FGFR2	1.29829291
24	PAK3	1.27598489
25	GRK1	1.24184198
26	MARK1	1.23637584
27	CAMK1D	1.20772606
28	PINK1	1.19736774
29	SGK2	1.18699656
30	TAOK3	1.18570871
31	OXSR1	1.14794442
32	WEE1	1.13280705
33	INSRR	1.12512947
34	PIK3CA	1.09045782
35	STK3	1.08610462
36	MKNK1	1.05411481
37	TGFBR1	1.04205473
38	ZAK	1.00221774
39	PTK2B	0.99107521
40	NLK	0.97124359
41	TRPM7	0.96871434
42	CAMKK2	0.91396360
43	WNK1	0.90143908
44	EPHA3	0.88206783
45	PRKCE	0.76641208
46	ADRBK1	0.74376789
47	PLK2	0.72691639
48	IRAK1	0.69245820
49	MELK	0.69160336
50	FER	0.68897124
51	ERBB3	0.66134589
52	SGK223	0.65111766
53	SGK494	0.65111766
54	PRKAA2	0.64387971
55	CDK3	0.64379956
56	ERBB4	0.62368304
57	MAP3K7	0.61252591
58	CDK12	0.59368960
59	ATM	0.58911066
60	FLT3	0.58771829
61	PRKAA1	0.58659899
62	STK38	0.57861255
63	BCR	0.57499848
64	NTRK2	0.56982238
65	NEK2	0.55540067
66	PKN1	0.53313130
67	MARK3	0.53110738
68	SGK3	0.52855700
69	TEC	0.52172713
70	TYRO3	0.52020472
71	PLK3	0.51102985
72	ATR	0.50837479
73	CHEK2	0.47828869
74	ERBB2	0.46616885
75	SIK2	0.46439598
76	NEK9	0.44306091
77	CSNK1A1L	0.42904451
78	CAMK4	0.42871257
79	MAPKAPK3	0.42389236
80	PIK3CG	0.41940971
81	EIF2AK3	0.41841255
82	PRKCG	0.41646753
83	SGK1	0.41196036
84	PDGFRB	0.40511742
85	CSNK1G1	0.40327550
86	FGFR1	0.39783925
87	MAPK15	0.39512235
88	CSNK1D	0.38809843
89	PRKACB	0.38605727
90	DYRK1A	0.38482354
91	CHUK	0.37963574
92	CAMK2A	0.36629767
93	STK11	0.35128019
94	PRKCH	0.34877743
95	EPHA4	0.34852925
96	TNK2	0.34528122
97	PLK4	0.32673264
98	TRIM28	0.32474815
99	GSK3B	0.31948612
100	YES1	0.31360501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Lysine degradation_Homo sapiens_hsa00310	2.30455875
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.14687000
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.10796994
4	Phototransduction_Homo sapiens_hsa04744	2.09890623
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.09023677
6	ABC transporters_Homo sapiens_hsa02010	2.08702072
7	Butanoate metabolism_Homo sapiens_hsa00650	2.06012850
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00047134
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99797195
10	Nitrogen metabolism_Homo sapiens_hsa00910	1.96923824
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95565367
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.74196006
13	Nicotine addiction_Homo sapiens_hsa05033	1.71825691
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.71691155
15	Homologous recombination_Homo sapiens_hsa03440	1.71321084
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64365634
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63833334
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.59704684
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59105881
20	Basal transcription factors_Homo sapiens_hsa03022	1.52802691
21	Taste transduction_Homo sapiens_hsa04742	1.51062004
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48081325
23	Circadian rhythm_Homo sapiens_hsa04710	1.46371920
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45090903
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41638403
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.39028518
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.29837278
28	Olfactory transduction_Homo sapiens_hsa04740	1.24193938
29	Morphine addiction_Homo sapiens_hsa05032	1.23564931
30	Propanoate metabolism_Homo sapiens_hsa00640	1.22937141
31	Insulin secretion_Homo sapiens_hsa04911	1.16671885
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14159095
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13221623
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12427095
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11426594
36	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.10654861
37	Circadian entrainment_Homo sapiens_hsa04713	1.10052998
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07722890
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06056196
40	One carbon pool by folate_Homo sapiens_hsa00670	1.05457927
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05015979
42	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.01206081
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00540514
44	Serotonergic synapse_Homo sapiens_hsa04726	0.99124818
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.92588207
46	Histidine metabolism_Homo sapiens_hsa00340	0.92349911
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.89180949
48	RNA degradation_Homo sapiens_hsa03018	0.88789197
49	GABAergic synapse_Homo sapiens_hsa04727	0.87580238
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86042686
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.84848885
52	Long-term depression_Homo sapiens_hsa04730	0.82716376
53	Salivary secretion_Homo sapiens_hsa04970	0.80163998
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80082090
55	Axon guidance_Homo sapiens_hsa04360	0.79501391
56	Protein export_Homo sapiens_hsa03060	0.79313028
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79144988
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77738293
59	MicroRNAs in cancer_Homo sapiens_hsa05206	0.77613484
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76279052
61	Type II diabetes mellitus_Homo sapiens_hsa04930	0.75501126
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75335965
63	FoxO signaling pathway_Homo sapiens_hsa04068	0.74332177
64	Cholinergic synapse_Homo sapiens_hsa04725	0.72659078
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.71965547
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68445424
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68172520
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68070751
69	Caffeine metabolism_Homo sapiens_hsa00232	0.67407632
70	Choline metabolism in cancer_Homo sapiens_hsa05231	0.67127629
71	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65807938
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.64909339
73	Melanoma_Homo sapiens_hsa05218	0.63883216
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63295890
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61716951
76	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61234581
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61166121
78	Retinol metabolism_Homo sapiens_hsa00830	0.60830294
79	Regulation of autophagy_Homo sapiens_hsa04140	0.60727704
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60393591
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59997067
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59005278
83	Cocaine addiction_Homo sapiens_hsa05030	0.58350046
84	Renin secretion_Homo sapiens_hsa04924	0.57915180
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56292060
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.55140933
87	Estrogen signaling pathway_Homo sapiens_hsa04915	0.54730927
88	Amphetamine addiction_Homo sapiens_hsa05031	0.54026936
89	Prostate cancer_Homo sapiens_hsa05215	0.51571468
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51545690
91	p53 signaling pathway_Homo sapiens_hsa04115	0.50141483
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49888246
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.48792187
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.46935185
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46173386
96	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45139020
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45073759
98	Ras signaling pathway_Homo sapiens_hsa04014	0.44236221
99	Fatty acid degradation_Homo sapiens_hsa00071	0.41523868
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.41440872

ZNF621

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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