ZNF622

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.10715922
2ribosome assembly (GO:0042255)4.79470505
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.36274664
4regulation of mitochondrial translation (GO:0070129)4.33085669
5regulation of cellular amino acid metabolic process (GO:0006521)4.28464853
6negative regulation of ligase activity (GO:0051352)4.16563072
7negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.16563072
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.16512292
9activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.15849574
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.04220044
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.01775148
12heart process (GO:0003015)4.00481802
13heart contraction (GO:0060047)4.00481802
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.98763189
15protein targeting to mitochondrion (GO:0006626)3.94791541
16antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.89703700
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.88448575
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.88448575
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.80978256
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.80978256
21signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.80978256
22ribosome biogenesis (GO:0042254)3.77468397
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.74193701
24protein maturation by protein folding (GO:0022417)3.71704474
25signal transduction involved in DNA integrity checkpoint (GO:0072401)3.70400510
26signal transduction involved in DNA damage checkpoint (GO:0072422)3.70400510
27positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.70282643
28protein localization to mitochondrion (GO:0070585)3.66222791
29protein deneddylation (GO:0000338)3.65893193
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.63006937
31establishment of protein localization to mitochondrion (GO:0072655)3.62533606
32Golgi transport vesicle coating (GO:0048200)3.60616707
33COPI coating of Golgi vesicle (GO:0048205)3.60616707
34positive regulation of ligase activity (GO:0051351)3.58498043
35DNA deamination (GO:0045006)3.51793275
36cullin deneddylation (GO:0010388)3.47450471
37pseudouridine synthesis (GO:0001522)3.47006478
38rRNA modification (GO:0000154)3.44054549
39ER overload response (GO:0006983)3.42826720
40tRNA methylation (GO:0030488)3.37938647
41de novo protein folding (GO:0006458)3.37543717
42regulation of ubiquitin-protein transferase activity (GO:0051438)3.35534977
43establishment of viral latency (GO:0019043)3.32093160
44tRNA aminoacylation for protein translation (GO:0006418)3.28362258
45regulation of ligase activity (GO:0051340)3.27136283
46de novo posttranslational protein folding (GO:0051084)3.26037544
47antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.20173857
48cellular response to arsenic-containing substance (GO:0071243)3.16927469
49regulation of cellular amine metabolic process (GO:0033238)3.13387899
50amino acid activation (GO:0043038)3.11014735
51tRNA aminoacylation (GO:0043039)3.11014735
52viral mRNA export from host cell nucleus (GO:0046784)3.03705210
53ribonucleoprotein complex biogenesis (GO:0022613)3.02869650
54positive regulation of cell cycle arrest (GO:0071158)3.02299812
55response to redox state (GO:0051775)3.01005799
56establishment of integrated proviral latency (GO:0075713)2.96534383
57establishment of protein localization to mitochondrial membrane (GO:0090151)2.95479334
58chaperone-mediated protein transport (GO:0072321)2.95407188
59mitochondrial RNA metabolic process (GO:0000959)2.95048742
60cellular component biogenesis (GO:0044085)2.94695974
61positive regulation of mitochondrial fission (GO:0090141)2.93870092
62negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.91366994
63negative regulation of defense response to virus (GO:0050687)2.88718482
64negative regulation of protein ubiquitination (GO:0031397)2.86736369
65maturation of 5.8S rRNA (GO:0000460)2.85879686
66GDP-mannose metabolic process (GO:0019673)2.84659867
67DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84596534
68ribosomal large subunit biogenesis (GO:0042273)2.83135037
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82695559
70protein complex biogenesis (GO:0070271)2.82477118
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82236361
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.82236361
73NADH dehydrogenase complex assembly (GO:0010257)2.82236361
74mitochondrial respiratory chain complex assembly (GO:0033108)2.79770886
75binding of sperm to zona pellucida (GO:0007339)2.79371901
76tricarboxylic acid cycle (GO:0006099)2.79342948
77termination of RNA polymerase III transcription (GO:0006386)2.78170607
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.78170607
79iron-sulfur cluster assembly (GO:0016226)2.74940333
80metallo-sulfur cluster assembly (GO:0031163)2.74940333
81negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.74736320
82signal transduction in response to DNA damage (GO:0042770)2.71647093
83mitochondrial fusion (GO:0008053)2.70613368
84ribonucleoprotein complex disassembly (GO:0032988)2.69416615
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68775660
86regulation of translational termination (GO:0006449)2.66867640
87rRNA processing (GO:0006364)2.66478707
88chaperone mediated protein folding requiring cofactor (GO:0051085)2.66428308
89nucleobase-containing small molecule interconversion (GO:0015949)2.64155066
90lipopolysaccharide biosynthetic process (GO:0009103)2.59533663
91regulation of retinoic acid receptor signaling pathway (GO:0048385)2.59374220
92NIK/NF-kappaB signaling (GO:0038061)2.58784936
93formation of translation preinitiation complex (GO:0001731)2.56386197
94rRNA methylation (GO:0031167)2.54384892
95peptidyl-histidine modification (GO:0018202)2.53899854
96rRNA metabolic process (GO:0016072)2.53074041
97positive regulation of protein ubiquitination (GO:0031398)2.51351352
98tRNA metabolic process (GO:0006399)2.49628791
99regulation of cell cycle arrest (GO:0071156)2.47945921
100negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47751186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31139343
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.11536548
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.07984965
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76405140
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35189857
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27143802
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.23550244
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.09989609
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01363196
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.98376767
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67226949
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67064353
13DCP1A_22483619_ChIP-Seq_HELA_Human2.51654798
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48618235
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48362931
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48104466
17E2F7_22180533_ChIP-Seq_HELA_Human2.47883354
18VDR_23849224_ChIP-Seq_CD4+_Human2.37804177
19* GABP_19822575_ChIP-Seq_HepG2_Human2.34452416
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30514939
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29757395
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25031489
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24888768
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19657424
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19301841
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.11388694
27FOXP3_21729870_ChIP-Seq_TREG_Human2.06485662
28XRN2_22483619_ChIP-Seq_HELA_Human1.96689446
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93964981
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93033340
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.91233418
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90162293
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88895006
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87027408
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86799549
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83344453
37TFEB_21752829_ChIP-Seq_HELA_Human1.77501431
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.72805971
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72163068
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71894583
41ELK1_19687146_ChIP-ChIP_HELA_Human1.71043943
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70775593
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68270761
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64844651
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63829526
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63170178
47ZNF263_19887448_ChIP-Seq_K562_Human1.62226401
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61897504
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61688410
50TTF2_22483619_ChIP-Seq_HELA_Human1.59604864
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59313310
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49424121
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48986967
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48669173
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47638152
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47064907
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43720825
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42664333
59CIITA_25753668_ChIP-Seq_RAJI_Human1.38420547
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38408262
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36392425
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35737385
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31735330
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30827534
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29373762
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24448689
67KDM5A_27292631_Chip-Seq_BREAST_Human1.22713777
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21668999
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21296633
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19921024
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17558979
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16079883
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.14092148
74ATF3_27146783_Chip-Seq_COLON_Human1.12624431
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.11684860
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08608771
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08327201
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07893847
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07414503
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07146698
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06684051
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06601387
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05454339
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03681428
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01308122
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99930522
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97793091
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.96860308
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.93414346
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93036927
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93015441
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91382995
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91024454
94ELF5_23300383_ChIP-Seq_T47D_Human0.91016665
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90907679
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90799722
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88914252
98AR_21909140_ChIP-Seq_LNCAP_Human0.88563817
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87722509
100MYC_18940864_ChIP-ChIP_HL60_Human0.85956272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.75165950
2MP0003693_abnormal_embryo_hatching4.16500747
3MP0009840_abnormal_foam_cell3.78095414
4MP0002837_dystrophic_cardiac_calcinosis3.72666466
5MP0008058_abnormal_DNA_repair3.39292909
6MP0005058_abnormal_lysosome_morphology3.26876601
7MP0003186_abnormal_redox_activity2.76998727
8MP0008260_abnormal_autophagy2.74993463
9MP0003786_premature_aging2.53219089
10MP0004957_abnormal_blastocyst_morpholog2.47393876
11MP0008007_abnormal_cellular_replicative2.47027495
12MP0002139_abnormal_hepatobiliary_system2.35452745
13MP0003221_abnormal_cardiomyocyte_apopto2.26541354
14MP0002877_abnormal_melanocyte_morpholog2.21335446
15MP0006036_abnormal_mitochondrial_physio2.08588097
16MP0001853_heart_inflammation1.99042122
17MP0005330_cardiomyopathy1.98250157
18MP0004084_abnormal_cardiac_muscle1.88840525
19MP0000358_abnormal_cell_content/1.87896263
20MP0002148_abnormal_hypersensitivity_rea1.84577364
21MP0006035_abnormal_mitochondrial_morpho1.80624473
22MP0001542_abnormal_bone_strength1.79589152
23MP0005451_abnormal_body_composition1.78217926
24MP0009785_altered_susceptibility_to1.76594518
25MP0009333_abnormal_splenocyte_physiolog1.68957431
26MP0000343_altered_response_to1.64877681
27MP0003077_abnormal_cell_cycle1.64578658
28MP0003111_abnormal_nucleus_morphology1.62494492
29MP0002332_abnormal_exercise_endurance1.61586081
30MP0004215_abnormal_myocardial_fiber1.60688908
31MP0004233_abnormal_muscle_weight1.45671948
32MP0008932_abnormal_embryonic_tissue1.44097157
33MP0010094_abnormal_chromosome_stability1.42136483
34MP0001727_abnormal_embryo_implantation1.41162791
35MP0002090_abnormal_vision1.40642340
36MP0005671_abnormal_response_to1.36104205
37MP0005083_abnormal_biliary_tract1.35132036
38MP0002269_muscular_atrophy1.30705132
39MP0006082_CNS_inflammation1.30470871
40MP0001243_abnormal_dermal_layer1.23263192
41MP0002138_abnormal_hepatobiliary_system1.21809550
42MP0005410_abnormal_fertilization1.21267358
43MP0003646_muscle_fatigue1.15208634
44MP0000685_abnormal_immune_system1.15190989
45MP0000490_abnormal_crypts_of1.14349343
46MP0008789_abnormal_olfactory_epithelium1.13038374
47MP0004036_abnormal_muscle_relaxation1.13035304
48MP0005499_abnormal_olfactory_system1.11546418
49MP0005394_taste/olfaction_phenotype1.11546418
50MP0005000_abnormal_immune_tolerance1.11078707
51MP0003137_abnormal_impulse_conducting1.10595925
52MP0006072_abnormal_retinal_apoptosis1.08173770
53MP0003436_decreased_susceptibility_to1.08103790
54MP0003123_paternal_imprinting1.07911217
55MP0000015_abnormal_ear_pigmentation1.05483735
56MP0005257_abnormal_intraocular_pressure1.03583701
57MP0001835_abnormal_antigen_presentation1.02031518
58MP0005623_abnormal_meninges_morphology1.01592331
59MP0002972_abnormal_cardiac_muscle1.01590441
60MP0000750_abnormal_muscle_regeneration0.99353201
61MP0001529_abnormal_vocalization0.97498295
62MP0000604_amyloidosis0.96619093
63MP0002452_abnormal_antigen_presenting0.94743863
64MP0000749_muscle_degeneration0.94412714
65MP0009764_decreased_sensitivity_to0.94316627
66MP0000858_altered_metastatic_potential0.93947498
67MP0005266_abnormal_metabolism0.92475664
68MP0005084_abnormal_gallbladder_morpholo0.92217039
69MP0001730_embryonic_growth_arrest0.91307313
70MP0003828_pulmonary_edema0.91242932
71MP0004510_myositis0.90935427
72MP0000372_irregular_coat_pigmentation0.90764937
73MP0005165_increased_susceptibility_to0.89578070
74MP0001845_abnormal_inflammatory_respons0.86835917
75MP0002723_abnormal_immune_serum0.86613328
76MP0000313_abnormal_cell_death0.86069677
77MP0005384_cellular_phenotype0.85626692
78MP0005379_endocrine/exocrine_gland_phen0.83998244
79MP0001905_abnormal_dopamine_level0.82218862
80MP0002419_abnormal_innate_immunity0.80864890
81MP0000747_muscle_weakness0.79412523
82MP0003448_altered_tumor_morphology0.79260679
83MP0006054_spinal_hemorrhage0.78632384
84MP0003950_abnormal_plasma_membrane0.76433239
85MP0001929_abnormal_gametogenesis0.76271911
86MP0005025_abnormal_response_to0.74357466
87MP0005360_urolithiasis0.72126931
88MP0002163_abnormal_gland_morphology0.71520168
89MP0008004_abnormal_stomach_pH0.70842845
90MP0001790_abnormal_immune_system0.70823788
91MP0005387_immune_system_phenotype0.70823788
92MP0003718_maternal_effect0.70558391
93MP0001819_abnormal_immune_cell0.69899215
94MP0010386_abnormal_urinary_bladder0.69630964
95MP0002420_abnormal_adaptive_immunity0.69282097
96MP0002080_prenatal_lethality0.68098126
97MP0008469_abnormal_protein_level0.67964288
98MP0002210_abnormal_sex_determination0.67531076
99MP0003763_abnormal_thymus_physiology0.67520592
100MP0003075_altered_response_to0.65879902

Predicted human phenotypes

RankGene SetZ-score
1Increased intramyocellular lipid droplets (HP:0012240)4.42905053
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.23365198
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.23365198
4Renal Fanconi syndrome (HP:0001994)3.89651747
5Increased muscle lipid content (HP:0009058)3.86028574
6Abnormal mitochondria in muscle tissue (HP:0008316)3.83011529
7Upper limb muscle weakness (HP:0003484)3.64360114
8Increased hepatocellular lipid droplets (HP:0006565)3.59895300
9Acute necrotizing encephalopathy (HP:0006965)3.55398802
10Abnormality of glycolipid metabolism (HP:0010969)3.51802920
11Abnormality of liposaccharide metabolism (HP:0010968)3.51802920
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.51802920
13Increased CSF lactate (HP:0002490)3.47279527
14Lipid accumulation in hepatocytes (HP:0006561)3.46413706
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29728648
16Increased serum lactate (HP:0002151)3.27429321
17Mitochondrial inheritance (HP:0001427)3.22045800
18Exercise intolerance (HP:0003546)3.16485020
19Hepatocellular necrosis (HP:0001404)3.15243923
20Ragged-red muscle fibers (HP:0003200)3.14975424
21Hepatic necrosis (HP:0002605)3.13655179
22Multiple enchondromatosis (HP:0005701)3.12515584
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09877654
24Acute encephalopathy (HP:0006846)3.00453967
25Abnormality of glycolysis (HP:0004366)2.99296496
26Generalized aminoaciduria (HP:0002909)2.98846102
27Cholecystitis (HP:0001082)2.96628096
28Abnormal gallbladder physiology (HP:0012438)2.96628096
29Cerebral edema (HP:0002181)2.95024965
30Entropion (HP:0000621)2.93399367
31Vacuolated lymphocytes (HP:0001922)2.90859251
32Tetraparesis (HP:0002273)2.86628362
33Lactic acidosis (HP:0003128)2.86420396
34Upper motor neuron abnormality (HP:0002127)2.81053590
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80583075
36Progressive macrocephaly (HP:0004481)2.73050948
37Nausea (HP:0002018)2.57783844
38Microretrognathia (HP:0000308)2.53458529
39Increased serum pyruvate (HP:0003542)2.53433194
40Mutism (HP:0002300)2.52452327
41Hypokinesia (HP:0002375)2.52074891
42Progressive muscle weakness (HP:0003323)2.51644622
43Rough bone trabeculation (HP:0100670)2.46103158
44Type I transferrin isoform profile (HP:0003642)2.44200403
45Loss of speech (HP:0002371)2.44067261
46Abnormal pupillary function (HP:0007686)2.42868235
47Prolonged neonatal jaundice (HP:0006579)2.42125251
48Fasciculations (HP:0002380)2.41706958
49Abnormality of the anterior horn cell (HP:0006802)2.41565701
50Degeneration of anterior horn cells (HP:0002398)2.41565701
51Reduced antithrombin III activity (HP:0001976)2.37084924
52Cutaneous melanoma (HP:0012056)2.35100124
53Abnormality of fatty-acid metabolism (HP:0004359)2.34239709
54Microvesicular hepatic steatosis (HP:0001414)2.28562642
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28110976
56Abnormal protein N-linked glycosylation (HP:0012347)2.28110976
57Abnormal protein glycosylation (HP:0012346)2.28110976
58Abnormal glycosylation (HP:0012345)2.28110976
59Respiratory difficulties (HP:0002880)2.22516992
60Squamous cell carcinoma (HP:0002860)2.21099406
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18789178
62Abnormality of alanine metabolism (HP:0010916)2.18789178
63Hyperalaninemia (HP:0003348)2.18789178
64Sparse eyelashes (HP:0000653)2.07419200
65Exertional dyspnea (HP:0002875)2.06647581
66Hand muscle atrophy (HP:0009130)2.04864826
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00610234
68Abnormality of renal resorption (HP:0011038)2.00491196
69Abnormal trabecular bone morphology (HP:0100671)1.98374900
70Proximal tubulopathy (HP:0000114)1.98091814
71Vertebral compression fractures (HP:0002953)1.95543220
72CNS demyelination (HP:0007305)1.95445258
73Respiratory failure (HP:0002878)1.95330153
74Reduced subcutaneous adipose tissue (HP:0003758)1.91708920
75Rhabdomyolysis (HP:0003201)1.91017408
76Cerebral hypomyelination (HP:0006808)1.90640854
77Impaired proprioception (HP:0010831)1.89458582
78Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89437667
79Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87400960
80Stomatitis (HP:0010280)1.86959801
813-Methylglutaconic aciduria (HP:0003535)1.85789699
82Esophageal neoplasm (HP:0100751)1.85367649
83Neoplasm of head and neck (HP:0012288)1.85367649
84Abnormality of the motor neurons (HP:0002450)1.83709053
85Abnormal neuron morphology (HP:0012757)1.83709053
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.82215200
87Aplastic anemia (HP:0001915)1.81919015
88Distal upper limb amyotrophy (HP:0007149)1.81825611
89Upper limb amyotrophy (HP:0009129)1.81825611
90Glycosuria (HP:0003076)1.80734867
91Abnormality of urine glucose concentration (HP:0011016)1.80734867
92Gliosis (HP:0002171)1.80425291
93Axonal loss (HP:0003447)1.79684472
94Spastic diplegia (HP:0001264)1.79644765
95Abnormality of macrophages (HP:0004311)1.78263065
96Limb-girdle muscle atrophy (HP:0003797)1.77433859
97Shoulder girdle muscle weakness (HP:0003547)1.76987081
98Opisthotonus (HP:0002179)1.76946041
99Spastic paraparesis (HP:0002313)1.76122053
100Ventricular tachycardia (HP:0004756)1.74973765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.10791912
2PDK24.01449572
3NME23.94337663
4BUB13.15775605
5STK163.12398663
6TESK12.98816262
7MAP4K22.97679032
8PIM22.97394980
9MST42.68327704
10PBK2.32632533
11NEK12.23484409
12EIF2AK12.15912385
13ARAF2.15167860
14BCKDK2.08398118
15IRAK32.07291273
16GRK72.06396601
17VRK21.94991109
18MAP3K121.86409670
19SRPK11.84433571
20EIF2AK31.79967854
21TSSK61.69571220
22TAOK21.66367376
23ABL21.64725331
24LIMK11.61451798
25EPHA21.59719761
26MAP3K111.51264629
27TRIM281.50637031
28RPS6KA41.49795245
29MAP3K31.31178891
30SCYL21.30658655
31TBK11.28258839
32MAP3K51.25393114
33DAPK31.23796893
34LATS21.22320724
35MST1R1.18080064
36RPS6KA51.13244098
37TGFBR21.07648798
38AURKA1.07106643
39TLK11.06474316
40CDC71.01721948
41TAOK11.00938747
42NME10.96593996
43CLK10.95233403
44BCR0.92081003
45STK100.89286421
46MOS0.87394422
47KDR0.86485166
48ERBB40.82425089
49BRAF0.77827646
50FLT30.77717232
51PAK40.77235637
52ALK0.74531361
53CSNK1G30.74161602
54PRKCI0.72929833
55MYLK0.71881534
56CSNK1G20.71777165
57VRK10.68663231
58NEK90.66548408
59TTK0.65996127
60MAP2K20.64723500
61ZAK0.64105452
62PRKD30.62625701
63AURKB0.59157001
64IKBKB0.57219884
65PLK10.56414073
66PAK10.55627370
67CSNK2A10.53532760
68ILK0.53057637
69MAP3K80.49271925
70RAF10.47324906
71DAPK10.46483839
72ERBB30.45785486
73DYRK30.44610271
74IKBKE0.43347481
75MAPKAPK30.41460801
76CAMK2G0.39707831
77CSNK1A1L0.39254758
78CCNB10.38106874
79CHEK10.37669973
80PLK30.35898757
81STK40.35168803
82PIK3CG0.34857813
83PIM10.34630859
84AKT20.34141516
85CSNK2A20.33752190
86CAMK2D0.33453760
87CSNK1G10.31691918
88MAP2K70.29846039
89MARK30.29483563
90CDK140.29425236
91IRAK40.28953316
92MAPKAPK20.26427513
93TXK0.26242620
94ATR0.26215246
95CHEK20.24621527
96EIF2AK20.24445773
97LMTK20.24194697
98CDK70.23181835
99RPS6KA10.22348999
100CAMKK20.22046145

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.37179479
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89067301
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.73323327
4Protein export_Homo sapiens_hsa030602.64954780
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59033787
6Parkinsons disease_Homo sapiens_hsa050122.55599132
7Oxidative phosphorylation_Homo sapiens_hsa001902.55420250
8RNA polymerase_Homo sapiens_hsa030202.02052907
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87382064
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80803003
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77198938
12Folate biosynthesis_Homo sapiens_hsa007901.75130923
13Antigen processing and presentation_Homo sapiens_hsa046121.70001338
14Spliceosome_Homo sapiens_hsa030401.69449282
15DNA replication_Homo sapiens_hsa030301.69194199
16Huntingtons disease_Homo sapiens_hsa050161.64517797
17Sulfur relay system_Homo sapiens_hsa041221.64244520
18RNA transport_Homo sapiens_hsa030131.62791878
19Biosynthesis of amino acids_Homo sapiens_hsa012301.61583571
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58576473
21Ribosome_Homo sapiens_hsa030101.56329175
22Carbon metabolism_Homo sapiens_hsa012001.56116108
23Legionellosis_Homo sapiens_hsa051341.55184772
24Pyrimidine metabolism_Homo sapiens_hsa002401.47477189
25Mismatch repair_Homo sapiens_hsa034301.47033235
26Rheumatoid arthritis_Homo sapiens_hsa053231.42274382
27Lysosome_Homo sapiens_hsa041421.39704812
28Alzheimers disease_Homo sapiens_hsa050101.38846764
29Vibrio cholerae infection_Homo sapiens_hsa051101.38078233
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30125160
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30096352
32Regulation of autophagy_Homo sapiens_hsa041401.29605843
33Fatty acid elongation_Homo sapiens_hsa000621.28479505
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27444487
35Glutathione metabolism_Homo sapiens_hsa004801.26570544
36Galactose metabolism_Homo sapiens_hsa000521.23858977
37Non-homologous end-joining_Homo sapiens_hsa034501.22226719
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18491269
39Viral myocarditis_Homo sapiens_hsa054161.16262969
40Cardiac muscle contraction_Homo sapiens_hsa042601.15610740
41Other glycan degradation_Homo sapiens_hsa005111.15273724
42Graft-versus-host disease_Homo sapiens_hsa053321.14432318
43Pentose phosphate pathway_Homo sapiens_hsa000301.12843006
44Vitamin B6 metabolism_Homo sapiens_hsa007501.09942753
45Systemic lupus erythematosus_Homo sapiens_hsa053221.07323656
46Selenocompound metabolism_Homo sapiens_hsa004501.02423549
47Base excision repair_Homo sapiens_hsa034101.01841416
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00752539
49Sulfur metabolism_Homo sapiens_hsa009200.99315045
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.96899780
51RNA degradation_Homo sapiens_hsa030180.95599712
52Collecting duct acid secretion_Homo sapiens_hsa049660.94029616
53Basal transcription factors_Homo sapiens_hsa030220.93636923
54p53 signaling pathway_Homo sapiens_hsa041150.93391474
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91162335
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88731703
57Allograft rejection_Homo sapiens_hsa053300.87839919
58Shigellosis_Homo sapiens_hsa051310.87611604
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86134054
60Epstein-Barr virus infection_Homo sapiens_hsa051690.85472897
61Pyruvate metabolism_Homo sapiens_hsa006200.85226832
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83852886
63Purine metabolism_Homo sapiens_hsa002300.80019341
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77628572
65Fructose and mannose metabolism_Homo sapiens_hsa000510.77116107
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77059475
67Salmonella infection_Homo sapiens_hsa051320.75331410
68Phagosome_Homo sapiens_hsa041450.75016889
69Autoimmune thyroid disease_Homo sapiens_hsa053200.74184512
70Type I diabetes mellitus_Homo sapiens_hsa049400.72228171
71Nucleotide excision repair_Homo sapiens_hsa034200.71361420
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70171884
73Asthma_Homo sapiens_hsa053100.69264878
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67587075
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.66809336
76Apoptosis_Homo sapiens_hsa042100.66669583
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.63201235
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61090061
79Peroxisome_Homo sapiens_hsa041460.59693494
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59428088
81Metabolic pathways_Homo sapiens_hsa011000.57979614
82N-Glycan biosynthesis_Homo sapiens_hsa005100.56552210
83Sphingolipid metabolism_Homo sapiens_hsa006000.55989027
84Herpes simplex infection_Homo sapiens_hsa051680.55445885
85Primary immunodeficiency_Homo sapiens_hsa053400.49112455
86Steroid biosynthesis_Homo sapiens_hsa001000.47662852
87Synaptic vesicle cycle_Homo sapiens_hsa047210.46840091
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45866857
89Cell cycle_Homo sapiens_hsa041100.45322471
90Propanoate metabolism_Homo sapiens_hsa006400.42641401
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.41700408
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.41219092
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.40179153
94Viral carcinogenesis_Homo sapiens_hsa052030.39082846
95Tuberculosis_Homo sapiens_hsa051520.37601925
96Influenza A_Homo sapiens_hsa051640.34607401
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32870071
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31556116
99Prion diseases_Homo sapiens_hsa050200.29458860
100Fanconi anemia pathway_Homo sapiens_hsa034600.28586155

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