Rank | Gene Set | Z-score |
---|---|---|
1 | proteasome assembly (GO:0043248) | 5.10715922 |
2 | ribosome assembly (GO:0042255) | 4.79470505 |
3 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.36274664 |
4 | regulation of mitochondrial translation (GO:0070129) | 4.33085669 |
5 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.28464853 |
6 | negative regulation of ligase activity (GO:0051352) | 4.16563072 |
7 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.16563072 |
8 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.16512292 |
9 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 4.15849574 |
10 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.04220044 |
11 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.01775148 |
12 | heart process (GO:0003015) | 4.00481802 |
13 | heart contraction (GO:0060047) | 4.00481802 |
14 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.98763189 |
15 | protein targeting to mitochondrion (GO:0006626) | 3.94791541 |
16 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.89703700 |
17 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.88448575 |
18 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.88448575 |
19 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.80978256 |
20 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.80978256 |
21 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.80978256 |
22 | ribosome biogenesis (GO:0042254) | 3.77468397 |
23 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.74193701 |
24 | protein maturation by protein folding (GO:0022417) | 3.71704474 |
25 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.70400510 |
26 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.70400510 |
27 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.70282643 |
28 | protein localization to mitochondrion (GO:0070585) | 3.66222791 |
29 | protein deneddylation (GO:0000338) | 3.65893193 |
30 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.63006937 |
31 | establishment of protein localization to mitochondrion (GO:0072655) | 3.62533606 |
32 | Golgi transport vesicle coating (GO:0048200) | 3.60616707 |
33 | COPI coating of Golgi vesicle (GO:0048205) | 3.60616707 |
34 | positive regulation of ligase activity (GO:0051351) | 3.58498043 |
35 | DNA deamination (GO:0045006) | 3.51793275 |
36 | cullin deneddylation (GO:0010388) | 3.47450471 |
37 | pseudouridine synthesis (GO:0001522) | 3.47006478 |
38 | rRNA modification (GO:0000154) | 3.44054549 |
39 | ER overload response (GO:0006983) | 3.42826720 |
40 | tRNA methylation (GO:0030488) | 3.37938647 |
41 | de novo protein folding (GO:0006458) | 3.37543717 |
42 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.35534977 |
43 | establishment of viral latency (GO:0019043) | 3.32093160 |
44 | tRNA aminoacylation for protein translation (GO:0006418) | 3.28362258 |
45 | regulation of ligase activity (GO:0051340) | 3.27136283 |
46 | de novo posttranslational protein folding (GO:0051084) | 3.26037544 |
47 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.20173857 |
48 | cellular response to arsenic-containing substance (GO:0071243) | 3.16927469 |
49 | regulation of cellular amine metabolic process (GO:0033238) | 3.13387899 |
50 | amino acid activation (GO:0043038) | 3.11014735 |
51 | tRNA aminoacylation (GO:0043039) | 3.11014735 |
52 | viral mRNA export from host cell nucleus (GO:0046784) | 3.03705210 |
53 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.02869650 |
54 | positive regulation of cell cycle arrest (GO:0071158) | 3.02299812 |
55 | response to redox state (GO:0051775) | 3.01005799 |
56 | establishment of integrated proviral latency (GO:0075713) | 2.96534383 |
57 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.95479334 |
58 | chaperone-mediated protein transport (GO:0072321) | 2.95407188 |
59 | mitochondrial RNA metabolic process (GO:0000959) | 2.95048742 |
60 | cellular component biogenesis (GO:0044085) | 2.94695974 |
61 | positive regulation of mitochondrial fission (GO:0090141) | 2.93870092 |
62 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 2.91366994 |
63 | negative regulation of defense response to virus (GO:0050687) | 2.88718482 |
64 | negative regulation of protein ubiquitination (GO:0031397) | 2.86736369 |
65 | maturation of 5.8S rRNA (GO:0000460) | 2.85879686 |
66 | GDP-mannose metabolic process (GO:0019673) | 2.84659867 |
67 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.84596534 |
68 | ribosomal large subunit biogenesis (GO:0042273) | 2.83135037 |
69 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.82695559 |
70 | protein complex biogenesis (GO:0070271) | 2.82477118 |
71 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.82236361 |
72 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.82236361 |
73 | NADH dehydrogenase complex assembly (GO:0010257) | 2.82236361 |
74 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.79770886 |
75 | binding of sperm to zona pellucida (GO:0007339) | 2.79371901 |
76 | tricarboxylic acid cycle (GO:0006099) | 2.79342948 |
77 | termination of RNA polymerase III transcription (GO:0006386) | 2.78170607 |
78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.78170607 |
79 | iron-sulfur cluster assembly (GO:0016226) | 2.74940333 |
80 | metallo-sulfur cluster assembly (GO:0031163) | 2.74940333 |
81 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.74736320 |
82 | signal transduction in response to DNA damage (GO:0042770) | 2.71647093 |
83 | mitochondrial fusion (GO:0008053) | 2.70613368 |
84 | ribonucleoprotein complex disassembly (GO:0032988) | 2.69416615 |
85 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.68775660 |
86 | regulation of translational termination (GO:0006449) | 2.66867640 |
87 | rRNA processing (GO:0006364) | 2.66478707 |
88 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.66428308 |
89 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.64155066 |
90 | lipopolysaccharide biosynthetic process (GO:0009103) | 2.59533663 |
91 | regulation of retinoic acid receptor signaling pathway (GO:0048385) | 2.59374220 |
92 | NIK/NF-kappaB signaling (GO:0038061) | 2.58784936 |
93 | formation of translation preinitiation complex (GO:0001731) | 2.56386197 |
94 | rRNA methylation (GO:0031167) | 2.54384892 |
95 | peptidyl-histidine modification (GO:0018202) | 2.53899854 |
96 | rRNA metabolic process (GO:0016072) | 2.53074041 |
97 | positive regulation of protein ubiquitination (GO:0031398) | 2.51351352 |
98 | tRNA metabolic process (GO:0006399) | 2.49628791 |
99 | regulation of cell cycle arrest (GO:0071156) | 2.47945921 |
100 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.47751186 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.31139343 |
2 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.11536548 |
3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.07984965 |
4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.76405140 |
5 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.35189857 |
6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.27143802 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.23550244 |
8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.09989609 |
9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.01363196 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.98376767 |
11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.67226949 |
12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.67064353 |
13 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.51654798 |
14 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.48618235 |
15 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.48362931 |
16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.48104466 |
17 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.47883354 |
18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.37804177 |
19 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.34452416 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.30514939 |
21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.29757395 |
22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.25031489 |
23 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.24888768 |
24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.19657424 |
25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.19301841 |
26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.11388694 |
27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06485662 |
28 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.96689446 |
29 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.93964981 |
30 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.93033340 |
31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.91233418 |
32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.90162293 |
33 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.88895006 |
34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.87027408 |
35 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.86799549 |
36 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.83344453 |
37 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.77501431 |
38 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.72805971 |
39 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.72163068 |
40 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71894583 |
41 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.71043943 |
42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70775593 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68270761 |
44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64844651 |
45 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.63829526 |
46 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.63170178 |
47 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.62226401 |
48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.61897504 |
49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.61688410 |
50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.59604864 |
51 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.59313310 |
52 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.49424121 |
53 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.48986967 |
54 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.48669173 |
55 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47638152 |
56 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.47064907 |
57 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.43720825 |
58 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.42664333 |
59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.38420547 |
60 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.38408262 |
61 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.36392425 |
62 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.35737385 |
63 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.31735330 |
64 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.30827534 |
65 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.29373762 |
66 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.24448689 |
67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22713777 |
68 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21668999 |
69 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.21296633 |
70 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.19921024 |
71 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.17558979 |
72 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.16079883 |
73 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.14092148 |
74 | ATF3_27146783_Chip-Seq_COLON_Human | 1.12624431 |
75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.11684860 |
76 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.08608771 |
77 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.08327201 |
78 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.07893847 |
79 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07414503 |
80 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.07146698 |
81 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.06684051 |
82 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.06601387 |
83 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.05454339 |
84 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.03681428 |
85 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.01308122 |
86 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.99930522 |
87 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.97793091 |
88 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.96860308 |
89 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.93414346 |
90 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.93036927 |
91 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93015441 |
92 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.91382995 |
93 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.91024454 |
94 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.91016665 |
95 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90907679 |
96 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.90799722 |
97 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.88914252 |
98 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.88563817 |
99 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.87722509 |
100 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.85956272 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003806_abnormal_nucleotide_metabolis | 4.75165950 |
2 | MP0003693_abnormal_embryo_hatching | 4.16500747 |
3 | MP0009840_abnormal_foam_cell | 3.78095414 |
4 | MP0002837_dystrophic_cardiac_calcinosis | 3.72666466 |
5 | MP0008058_abnormal_DNA_repair | 3.39292909 |
6 | MP0005058_abnormal_lysosome_morphology | 3.26876601 |
7 | MP0003186_abnormal_redox_activity | 2.76998727 |
8 | MP0008260_abnormal_autophagy | 2.74993463 |
9 | MP0003786_premature_aging | 2.53219089 |
10 | MP0004957_abnormal_blastocyst_morpholog | 2.47393876 |
11 | MP0008007_abnormal_cellular_replicative | 2.47027495 |
12 | MP0002139_abnormal_hepatobiliary_system | 2.35452745 |
13 | MP0003221_abnormal_cardiomyocyte_apopto | 2.26541354 |
14 | MP0002877_abnormal_melanocyte_morpholog | 2.21335446 |
15 | MP0006036_abnormal_mitochondrial_physio | 2.08588097 |
16 | MP0001853_heart_inflammation | 1.99042122 |
17 | MP0005330_cardiomyopathy | 1.98250157 |
18 | MP0004084_abnormal_cardiac_muscle | 1.88840525 |
19 | MP0000358_abnormal_cell_content/ | 1.87896263 |
20 | MP0002148_abnormal_hypersensitivity_rea | 1.84577364 |
21 | MP0006035_abnormal_mitochondrial_morpho | 1.80624473 |
22 | MP0001542_abnormal_bone_strength | 1.79589152 |
23 | MP0005451_abnormal_body_composition | 1.78217926 |
24 | MP0009785_altered_susceptibility_to | 1.76594518 |
25 | MP0009333_abnormal_splenocyte_physiolog | 1.68957431 |
26 | MP0000343_altered_response_to | 1.64877681 |
27 | MP0003077_abnormal_cell_cycle | 1.64578658 |
28 | MP0003111_abnormal_nucleus_morphology | 1.62494492 |
29 | MP0002332_abnormal_exercise_endurance | 1.61586081 |
30 | MP0004215_abnormal_myocardial_fiber | 1.60688908 |
31 | MP0004233_abnormal_muscle_weight | 1.45671948 |
32 | MP0008932_abnormal_embryonic_tissue | 1.44097157 |
33 | MP0010094_abnormal_chromosome_stability | 1.42136483 |
34 | MP0001727_abnormal_embryo_implantation | 1.41162791 |
35 | MP0002090_abnormal_vision | 1.40642340 |
36 | MP0005671_abnormal_response_to | 1.36104205 |
37 | MP0005083_abnormal_biliary_tract | 1.35132036 |
38 | MP0002269_muscular_atrophy | 1.30705132 |
39 | MP0006082_CNS_inflammation | 1.30470871 |
40 | MP0001243_abnormal_dermal_layer | 1.23263192 |
41 | MP0002138_abnormal_hepatobiliary_system | 1.21809550 |
42 | MP0005410_abnormal_fertilization | 1.21267358 |
43 | MP0003646_muscle_fatigue | 1.15208634 |
44 | MP0000685_abnormal_immune_system | 1.15190989 |
45 | MP0000490_abnormal_crypts_of | 1.14349343 |
46 | MP0008789_abnormal_olfactory_epithelium | 1.13038374 |
47 | MP0004036_abnormal_muscle_relaxation | 1.13035304 |
48 | MP0005499_abnormal_olfactory_system | 1.11546418 |
49 | MP0005394_taste/olfaction_phenotype | 1.11546418 |
50 | MP0005000_abnormal_immune_tolerance | 1.11078707 |
51 | MP0003137_abnormal_impulse_conducting | 1.10595925 |
52 | MP0006072_abnormal_retinal_apoptosis | 1.08173770 |
53 | MP0003436_decreased_susceptibility_to | 1.08103790 |
54 | MP0003123_paternal_imprinting | 1.07911217 |
55 | MP0000015_abnormal_ear_pigmentation | 1.05483735 |
56 | MP0005257_abnormal_intraocular_pressure | 1.03583701 |
57 | MP0001835_abnormal_antigen_presentation | 1.02031518 |
58 | MP0005623_abnormal_meninges_morphology | 1.01592331 |
59 | MP0002972_abnormal_cardiac_muscle | 1.01590441 |
60 | MP0000750_abnormal_muscle_regeneration | 0.99353201 |
61 | MP0001529_abnormal_vocalization | 0.97498295 |
62 | MP0000604_amyloidosis | 0.96619093 |
63 | MP0002452_abnormal_antigen_presenting | 0.94743863 |
64 | MP0000749_muscle_degeneration | 0.94412714 |
65 | MP0009764_decreased_sensitivity_to | 0.94316627 |
66 | MP0000858_altered_metastatic_potential | 0.93947498 |
67 | MP0005266_abnormal_metabolism | 0.92475664 |
68 | MP0005084_abnormal_gallbladder_morpholo | 0.92217039 |
69 | MP0001730_embryonic_growth_arrest | 0.91307313 |
70 | MP0003828_pulmonary_edema | 0.91242932 |
71 | MP0004510_myositis | 0.90935427 |
72 | MP0000372_irregular_coat_pigmentation | 0.90764937 |
73 | MP0005165_increased_susceptibility_to | 0.89578070 |
74 | MP0001845_abnormal_inflammatory_respons | 0.86835917 |
75 | MP0002723_abnormal_immune_serum | 0.86613328 |
76 | MP0000313_abnormal_cell_death | 0.86069677 |
77 | MP0005384_cellular_phenotype | 0.85626692 |
78 | MP0005379_endocrine/exocrine_gland_phen | 0.83998244 |
79 | MP0001905_abnormal_dopamine_level | 0.82218862 |
80 | MP0002419_abnormal_innate_immunity | 0.80864890 |
81 | MP0000747_muscle_weakness | 0.79412523 |
82 | MP0003448_altered_tumor_morphology | 0.79260679 |
83 | MP0006054_spinal_hemorrhage | 0.78632384 |
84 | MP0003950_abnormal_plasma_membrane | 0.76433239 |
85 | MP0001929_abnormal_gametogenesis | 0.76271911 |
86 | MP0005025_abnormal_response_to | 0.74357466 |
87 | MP0005360_urolithiasis | 0.72126931 |
88 | MP0002163_abnormal_gland_morphology | 0.71520168 |
89 | MP0008004_abnormal_stomach_pH | 0.70842845 |
90 | MP0001790_abnormal_immune_system | 0.70823788 |
91 | MP0005387_immune_system_phenotype | 0.70823788 |
92 | MP0003718_maternal_effect | 0.70558391 |
93 | MP0001819_abnormal_immune_cell | 0.69899215 |
94 | MP0010386_abnormal_urinary_bladder | 0.69630964 |
95 | MP0002420_abnormal_adaptive_immunity | 0.69282097 |
96 | MP0002080_prenatal_lethality | 0.68098126 |
97 | MP0008469_abnormal_protein_level | 0.67964288 |
98 | MP0002210_abnormal_sex_determination | 0.67531076 |
99 | MP0003763_abnormal_thymus_physiology | 0.67520592 |
100 | MP0003075_altered_response_to | 0.65879902 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased intramyocellular lipid droplets (HP:0012240) | 4.42905053 |
2 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.23365198 |
3 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.23365198 |
4 | Renal Fanconi syndrome (HP:0001994) | 3.89651747 |
5 | Increased muscle lipid content (HP:0009058) | 3.86028574 |
6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.83011529 |
7 | Upper limb muscle weakness (HP:0003484) | 3.64360114 |
8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.59895300 |
9 | Acute necrotizing encephalopathy (HP:0006965) | 3.55398802 |
10 | Abnormality of glycolipid metabolism (HP:0010969) | 3.51802920 |
11 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.51802920 |
12 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.51802920 |
13 | Increased CSF lactate (HP:0002490) | 3.47279527 |
14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.46413706 |
15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.29728648 |
16 | Increased serum lactate (HP:0002151) | 3.27429321 |
17 | Mitochondrial inheritance (HP:0001427) | 3.22045800 |
18 | Exercise intolerance (HP:0003546) | 3.16485020 |
19 | Hepatocellular necrosis (HP:0001404) | 3.15243923 |
20 | Ragged-red muscle fibers (HP:0003200) | 3.14975424 |
21 | Hepatic necrosis (HP:0002605) | 3.13655179 |
22 | Multiple enchondromatosis (HP:0005701) | 3.12515584 |
23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.09877654 |
24 | Acute encephalopathy (HP:0006846) | 3.00453967 |
25 | Abnormality of glycolysis (HP:0004366) | 2.99296496 |
26 | Generalized aminoaciduria (HP:0002909) | 2.98846102 |
27 | Cholecystitis (HP:0001082) | 2.96628096 |
28 | Abnormal gallbladder physiology (HP:0012438) | 2.96628096 |
29 | Cerebral edema (HP:0002181) | 2.95024965 |
30 | Entropion (HP:0000621) | 2.93399367 |
31 | Vacuolated lymphocytes (HP:0001922) | 2.90859251 |
32 | Tetraparesis (HP:0002273) | 2.86628362 |
33 | Lactic acidosis (HP:0003128) | 2.86420396 |
34 | Upper motor neuron abnormality (HP:0002127) | 2.81053590 |
35 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.80583075 |
36 | Progressive macrocephaly (HP:0004481) | 2.73050948 |
37 | Nausea (HP:0002018) | 2.57783844 |
38 | Microretrognathia (HP:0000308) | 2.53458529 |
39 | Increased serum pyruvate (HP:0003542) | 2.53433194 |
40 | Mutism (HP:0002300) | 2.52452327 |
41 | Hypokinesia (HP:0002375) | 2.52074891 |
42 | Progressive muscle weakness (HP:0003323) | 2.51644622 |
43 | Rough bone trabeculation (HP:0100670) | 2.46103158 |
44 | Type I transferrin isoform profile (HP:0003642) | 2.44200403 |
45 | Loss of speech (HP:0002371) | 2.44067261 |
46 | Abnormal pupillary function (HP:0007686) | 2.42868235 |
47 | Prolonged neonatal jaundice (HP:0006579) | 2.42125251 |
48 | Fasciculations (HP:0002380) | 2.41706958 |
49 | Abnormality of the anterior horn cell (HP:0006802) | 2.41565701 |
50 | Degeneration of anterior horn cells (HP:0002398) | 2.41565701 |
51 | Reduced antithrombin III activity (HP:0001976) | 2.37084924 |
52 | Cutaneous melanoma (HP:0012056) | 2.35100124 |
53 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.34239709 |
54 | Microvesicular hepatic steatosis (HP:0001414) | 2.28562642 |
55 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.28110976 |
56 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.28110976 |
57 | Abnormal protein glycosylation (HP:0012346) | 2.28110976 |
58 | Abnormal glycosylation (HP:0012345) | 2.28110976 |
59 | Respiratory difficulties (HP:0002880) | 2.22516992 |
60 | Squamous cell carcinoma (HP:0002860) | 2.21099406 |
61 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.18789178 |
62 | Abnormality of alanine metabolism (HP:0010916) | 2.18789178 |
63 | Hyperalaninemia (HP:0003348) | 2.18789178 |
64 | Sparse eyelashes (HP:0000653) | 2.07419200 |
65 | Exertional dyspnea (HP:0002875) | 2.06647581 |
66 | Hand muscle atrophy (HP:0009130) | 2.04864826 |
67 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.00610234 |
68 | Abnormality of renal resorption (HP:0011038) | 2.00491196 |
69 | Abnormal trabecular bone morphology (HP:0100671) | 1.98374900 |
70 | Proximal tubulopathy (HP:0000114) | 1.98091814 |
71 | Vertebral compression fractures (HP:0002953) | 1.95543220 |
72 | CNS demyelination (HP:0007305) | 1.95445258 |
73 | Respiratory failure (HP:0002878) | 1.95330153 |
74 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.91708920 |
75 | Rhabdomyolysis (HP:0003201) | 1.91017408 |
76 | Cerebral hypomyelination (HP:0006808) | 1.90640854 |
77 | Impaired proprioception (HP:0010831) | 1.89458582 |
78 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.89437667 |
79 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.87400960 |
80 | Stomatitis (HP:0010280) | 1.86959801 |
81 | 3-Methylglutaconic aciduria (HP:0003535) | 1.85789699 |
82 | Esophageal neoplasm (HP:0100751) | 1.85367649 |
83 | Neoplasm of head and neck (HP:0012288) | 1.85367649 |
84 | Abnormality of the motor neurons (HP:0002450) | 1.83709053 |
85 | Abnormal neuron morphology (HP:0012757) | 1.83709053 |
86 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.82215200 |
87 | Aplastic anemia (HP:0001915) | 1.81919015 |
88 | Distal upper limb amyotrophy (HP:0007149) | 1.81825611 |
89 | Upper limb amyotrophy (HP:0009129) | 1.81825611 |
90 | Glycosuria (HP:0003076) | 1.80734867 |
91 | Abnormality of urine glucose concentration (HP:0011016) | 1.80734867 |
92 | Gliosis (HP:0002171) | 1.80425291 |
93 | Axonal loss (HP:0003447) | 1.79684472 |
94 | Spastic diplegia (HP:0001264) | 1.79644765 |
95 | Abnormality of macrophages (HP:0004311) | 1.78263065 |
96 | Limb-girdle muscle atrophy (HP:0003797) | 1.77433859 |
97 | Shoulder girdle muscle weakness (HP:0003547) | 1.76987081 |
98 | Opisthotonus (HP:0002179) | 1.76946041 |
99 | Spastic paraparesis (HP:0002313) | 1.76122053 |
100 | Ventricular tachycardia (HP:0004756) | 1.74973765 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TESK2 | 4.10791912 |
2 | PDK2 | 4.01449572 |
3 | NME2 | 3.94337663 |
4 | BUB1 | 3.15775605 |
5 | STK16 | 3.12398663 |
6 | TESK1 | 2.98816262 |
7 | MAP4K2 | 2.97679032 |
8 | PIM2 | 2.97394980 |
9 | MST4 | 2.68327704 |
10 | PBK | 2.32632533 |
11 | NEK1 | 2.23484409 |
12 | EIF2AK1 | 2.15912385 |
13 | ARAF | 2.15167860 |
14 | BCKDK | 2.08398118 |
15 | IRAK3 | 2.07291273 |
16 | GRK7 | 2.06396601 |
17 | VRK2 | 1.94991109 |
18 | MAP3K12 | 1.86409670 |
19 | SRPK1 | 1.84433571 |
20 | EIF2AK3 | 1.79967854 |
21 | TSSK6 | 1.69571220 |
22 | TAOK2 | 1.66367376 |
23 | ABL2 | 1.64725331 |
24 | LIMK1 | 1.61451798 |
25 | EPHA2 | 1.59719761 |
26 | MAP3K11 | 1.51264629 |
27 | TRIM28 | 1.50637031 |
28 | RPS6KA4 | 1.49795245 |
29 | MAP3K3 | 1.31178891 |
30 | SCYL2 | 1.30658655 |
31 | TBK1 | 1.28258839 |
32 | MAP3K5 | 1.25393114 |
33 | DAPK3 | 1.23796893 |
34 | LATS2 | 1.22320724 |
35 | MST1R | 1.18080064 |
36 | RPS6KA5 | 1.13244098 |
37 | TGFBR2 | 1.07648798 |
38 | AURKA | 1.07106643 |
39 | TLK1 | 1.06474316 |
40 | CDC7 | 1.01721948 |
41 | TAOK1 | 1.00938747 |
42 | NME1 | 0.96593996 |
43 | CLK1 | 0.95233403 |
44 | BCR | 0.92081003 |
45 | STK10 | 0.89286421 |
46 | MOS | 0.87394422 |
47 | KDR | 0.86485166 |
48 | ERBB4 | 0.82425089 |
49 | BRAF | 0.77827646 |
50 | FLT3 | 0.77717232 |
51 | PAK4 | 0.77235637 |
52 | ALK | 0.74531361 |
53 | CSNK1G3 | 0.74161602 |
54 | PRKCI | 0.72929833 |
55 | MYLK | 0.71881534 |
56 | CSNK1G2 | 0.71777165 |
57 | VRK1 | 0.68663231 |
58 | NEK9 | 0.66548408 |
59 | TTK | 0.65996127 |
60 | MAP2K2 | 0.64723500 |
61 | ZAK | 0.64105452 |
62 | PRKD3 | 0.62625701 |
63 | AURKB | 0.59157001 |
64 | IKBKB | 0.57219884 |
65 | PLK1 | 0.56414073 |
66 | PAK1 | 0.55627370 |
67 | CSNK2A1 | 0.53532760 |
68 | ILK | 0.53057637 |
69 | MAP3K8 | 0.49271925 |
70 | RAF1 | 0.47324906 |
71 | DAPK1 | 0.46483839 |
72 | ERBB3 | 0.45785486 |
73 | DYRK3 | 0.44610271 |
74 | IKBKE | 0.43347481 |
75 | MAPKAPK3 | 0.41460801 |
76 | CAMK2G | 0.39707831 |
77 | CSNK1A1L | 0.39254758 |
78 | CCNB1 | 0.38106874 |
79 | CHEK1 | 0.37669973 |
80 | PLK3 | 0.35898757 |
81 | STK4 | 0.35168803 |
82 | PIK3CG | 0.34857813 |
83 | PIM1 | 0.34630859 |
84 | AKT2 | 0.34141516 |
85 | CSNK2A2 | 0.33752190 |
86 | CAMK2D | 0.33453760 |
87 | CSNK1G1 | 0.31691918 |
88 | MAP2K7 | 0.29846039 |
89 | MARK3 | 0.29483563 |
90 | CDK14 | 0.29425236 |
91 | IRAK4 | 0.28953316 |
92 | MAPKAPK2 | 0.26427513 |
93 | TXK | 0.26242620 |
94 | ATR | 0.26215246 |
95 | CHEK2 | 0.24621527 |
96 | EIF2AK2 | 0.24445773 |
97 | LMTK2 | 0.24194697 |
98 | CDK7 | 0.23181835 |
99 | RPS6KA1 | 0.22348999 |
100 | CAMKK2 | 0.22046145 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 5.37179479 |
2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.89067301 |
3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.73323327 |
4 | Protein export_Homo sapiens_hsa03060 | 2.64954780 |
5 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.59033787 |
6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.55599132 |
7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.55420250 |
8 | RNA polymerase_Homo sapiens_hsa03020 | 2.02052907 |
9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.87382064 |
10 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.80803003 |
11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.77198938 |
12 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.75130923 |
13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.70001338 |
14 | Spliceosome_Homo sapiens_hsa03040 | 1.69449282 |
15 | DNA replication_Homo sapiens_hsa03030 | 1.69194199 |
16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.64517797 |
17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.64244520 |
18 | RNA transport_Homo sapiens_hsa03013 | 1.62791878 |
19 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.61583571 |
20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.58576473 |
21 | Ribosome_Homo sapiens_hsa03010 | 1.56329175 |
22 | Carbon metabolism_Homo sapiens_hsa01200 | 1.56116108 |
23 | Legionellosis_Homo sapiens_hsa05134 | 1.55184772 |
24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47477189 |
25 | Mismatch repair_Homo sapiens_hsa03430 | 1.47033235 |
26 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.42274382 |
27 | Lysosome_Homo sapiens_hsa04142 | 1.39704812 |
28 | Alzheimers disease_Homo sapiens_hsa05010 | 1.38846764 |
29 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.38078233 |
30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.30125160 |
31 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.30096352 |
32 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.29605843 |
33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.28479505 |
34 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.27444487 |
35 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.26570544 |
36 | Galactose metabolism_Homo sapiens_hsa00052 | 1.23858977 |
37 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.22226719 |
38 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.18491269 |
39 | Viral myocarditis_Homo sapiens_hsa05416 | 1.16262969 |
40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.15610740 |
41 | Other glycan degradation_Homo sapiens_hsa00511 | 1.15273724 |
42 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.14432318 |
43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.12843006 |
44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.09942753 |
45 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.07323656 |
46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02423549 |
47 | Base excision repair_Homo sapiens_hsa03410 | 1.01841416 |
48 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.00752539 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.99315045 |
50 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.96899780 |
51 | RNA degradation_Homo sapiens_hsa03018 | 0.95599712 |
52 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.94029616 |
53 | Basal transcription factors_Homo sapiens_hsa03022 | 0.93636923 |
54 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.93391474 |
55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.91162335 |
56 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.88731703 |
57 | Allograft rejection_Homo sapiens_hsa05330 | 0.87839919 |
58 | Shigellosis_Homo sapiens_hsa05131 | 0.87611604 |
59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.86134054 |
60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85472897 |
61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85226832 |
62 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.83852886 |
63 | Purine metabolism_Homo sapiens_hsa00230 | 0.80019341 |
64 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.77628572 |
65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.77116107 |
66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77059475 |
67 | Salmonella infection_Homo sapiens_hsa05132 | 0.75331410 |
68 | Phagosome_Homo sapiens_hsa04145 | 0.75016889 |
69 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.74184512 |
70 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.72228171 |
71 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.71361420 |
72 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.70171884 |
73 | Asthma_Homo sapiens_hsa05310 | 0.69264878 |
74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.67587075 |
75 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.66809336 |
76 | Apoptosis_Homo sapiens_hsa04210 | 0.66669583 |
77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.63201235 |
78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.61090061 |
79 | Peroxisome_Homo sapiens_hsa04146 | 0.59693494 |
80 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.59428088 |
81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57979614 |
82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.56552210 |
83 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55989027 |
84 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.55445885 |
85 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.49112455 |
86 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.47662852 |
87 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.46840091 |
88 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.45866857 |
89 | Cell cycle_Homo sapiens_hsa04110 | 0.45322471 |
90 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.42641401 |
91 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.41700408 |
92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.41219092 |
93 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.40179153 |
94 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.39082846 |
95 | Tuberculosis_Homo sapiens_hsa05152 | 0.37601925 |
96 | Influenza A_Homo sapiens_hsa05164 | 0.34607401 |
97 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.32870071 |
98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.31556116 |
99 | Prion diseases_Homo sapiens_hsa05020 | 0.29458860 |
100 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.28586155 |