ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	3.94484646
2	cardiac right ventricle morphogenesis (GO:0003215)	3.54061222
3	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.36761688
4	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.36761688
5	regulation of translation, ncRNA-mediated (GO:0045974)	3.36761688
6	regulation of hippo signaling (GO:0035330)	3.36622135
7	neural tube formation (GO:0001841)	3.35708251
8	DNA damage induced protein phosphorylation (GO:0006975)	3.32315437
9	cytoplasmic mRNA processing body assembly (GO:0033962)	3.22457300
10	cochlea development (GO:0090102)	3.12551532
11	embryonic camera-type eye morphogenesis (GO:0048596)	3.10650502
12	interkinetic nuclear migration (GO:0022027)	3.03465781
13	histone H3-K9 methylation (GO:0051567)	3.00703328
14	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.85982116
15	nuclear pore organization (GO:0006999)	2.84411917
16	mitotic sister chromatid cohesion (GO:0007064)	2.82567940
17	central nervous system neuron axonogenesis (GO:0021955)	2.82516741
18	paraxial mesoderm development (GO:0048339)	2.79150461
19	cell migration in hindbrain (GO:0021535)	2.77944736
20	sympathetic nervous system development (GO:0048485)	2.76117553
21	regulation of protein polyubiquitination (GO:1902914)	2.75258661
22	regulation of telomere maintenance (GO:0032204)	2.73494400
23	central nervous system projection neuron axonogenesis (GO:0021952)	2.73231037
24	snRNA transcription (GO:0009301)	2.71232506
25	regulation of telomere maintenance via telomerase (GO:0032210)	2.66910950
26	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.65019346
27	monoubiquitinated protein deubiquitination (GO:0035520)	2.63376958
28	negative regulation of DNA repair (GO:0045738)	2.62452497
29	nuclear pore complex assembly (GO:0051292)	2.56529877
30	head development (GO:0060322)	2.53549848
31	inner ear receptor cell development (GO:0060119)	2.52885438
32	negative regulation of neurotransmitter secretion (GO:0046929)	2.52049508
33	sister chromatid cohesion (GO:0007062)	2.48690690
34	histone H3-K36 demethylation (GO:0070544)	2.45918916
35	limb bud formation (GO:0060174)	2.44061160
36	regulation of gene silencing by miRNA (GO:0060964)	2.42031293
37	regulation of gene silencing by RNA (GO:0060966)	2.42031293
38	regulation of posttranscriptional gene silencing (GO:0060147)	2.42031293
39	axonal fasciculation (GO:0007413)	2.39965533
40	protein K48-linked deubiquitination (GO:0071108)	2.39808204
41	polarized epithelial cell differentiation (GO:0030859)	2.39625752
42	auditory behavior (GO:0031223)	2.39114187
43	presynaptic membrane assembly (GO:0097105)	2.37892303
44	regulation of fatty acid beta-oxidation (GO:0031998)	2.37421658
45	coronary vasculature morphogenesis (GO:0060977)	2.33674627
46	mannose metabolic process (GO:0006013)	2.33328516
47	regulation of establishment of cell polarity (GO:2000114)	2.33034811
48	branching involved in prostate gland morphogenesis (GO:0060442)	2.32077635
49	synapse assembly (GO:0007416)	2.31983519
50	eyelid development in camera-type eye (GO:0061029)	2.30956690
51	nucleus localization (GO:0051647)	2.30854908
52	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.29059333
53	negative regulation of keratinocyte proliferation (GO:0010839)	2.27976696
54	negative regulation of neurotransmitter transport (GO:0051589)	2.27908871
55	histone H3-K9 modification (GO:0061647)	2.26970648
56	behavioral response to ethanol (GO:0048149)	2.25516717
57	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.25405939
58	microtubule nucleation (GO:0007020)	2.25306389
59	establishment of monopolar cell polarity (GO:0061162)	2.25197120
60	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.25197120
61	generation of neurons (GO:0048699)	2.22308773
62	olfactory bulb development (GO:0021772)	2.22249997
63	mechanosensory behavior (GO:0007638)	2.21832756
64	NLS-bearing protein import into nucleus (GO:0006607)	2.21829700
65	establishment of apical/basal cell polarity (GO:0035089)	2.20976048
66	protein K11-linked deubiquitination (GO:0035871)	2.20678164
67	startle response (GO:0001964)	2.20169134
68	embryonic eye morphogenesis (GO:0048048)	2.19610903
69	reflex (GO:0060004)	2.19000005
70	innervation (GO:0060384)	2.18896629
71	peptidyl-lysine trimethylation (GO:0018023)	2.17880058
72	regulation of DNA endoreduplication (GO:0032875)	2.16981449
73	cornea development in camera-type eye (GO:0061303)	2.16428210
74	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.16307531
75	neuronal stem cell maintenance (GO:0097150)	2.15627294
76	ganglion development (GO:0061548)	2.15459502
77	gene silencing by RNA (GO:0031047)	2.14766042
78	embryonic epithelial tube formation (GO:0001838)	2.14066234
79	inositol metabolic process (GO:0006020)	2.13868737
80	histone H2A monoubiquitination (GO:0035518)	2.13454254
81	indole-containing compound catabolic process (GO:0042436)	2.13139316
82	indolalkylamine catabolic process (GO:0046218)	2.13139316
83	tryptophan catabolic process (GO:0006569)	2.13139316
84	limb development (GO:0060173)	2.11913591
85	appendage development (GO:0048736)	2.11913591
86	negative regulation of telomere maintenance (GO:0032205)	2.11708233
87	regulation of centrosome duplication (GO:0010824)	2.11504178
88	peptidyl-lysine methylation (GO:0018022)	2.10515111
89	dorsal/ventral axis specification (GO:0009950)	2.10065092
90	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.09807893
91	meiotic chromosome segregation (GO:0045132)	2.09737431
92	kidney morphogenesis (GO:0060993)	2.09663981
93	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.09502346
94	sex differentiation (GO:0007548)	2.09045557
95	epithelial tube formation (GO:0072175)	2.09022730
96	morphogenesis of an epithelial sheet (GO:0002011)	2.08565528
97	macroautophagy (GO:0016236)	2.08538976
98	postsynaptic membrane organization (GO:0001941)	2.08216725
99	neuron recognition (GO:0008038)	2.08078022
100	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.07448404

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.61458359
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.26833225
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.09855426
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.00786972
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.99837834
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.94600773
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94056069
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.72886364
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.71776191
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.65603860
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29644067
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.29543911
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24712438
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21081885
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14282929
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.08595350
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.05811608
18	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.03530678
19	AR_21572438_ChIP-Seq_LNCaP_Human	2.02934295
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.01689568
21	EWS_26573619_Chip-Seq_HEK293_Human	1.97134197
22	AHR_22903824_ChIP-Seq_MCF-7_Human	1.91998903
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.89946548
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89392462
25	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.87563278
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.86887606
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.85193342
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79263581
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78656236
30	STAT3_23295773_ChIP-Seq_U87_Human	1.74411279
31	* NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72620925
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60294011
33	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.58595158
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52462565
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51452742
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51408721
37	TP53_16413492_ChIP-PET_HCT116_Human	1.50732581
38	TCF4_23295773_ChIP-Seq_U87_Human	1.50414129
39	P300_19829295_ChIP-Seq_ESCs_Human	1.49670647
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49664934
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49664934
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47334821
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43025673
44	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.42841679
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42641620
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41282027
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33315202
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32577256
49	AR_25329375_ChIP-Seq_VCAP_Human	1.26915545
50	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.22596819
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22430302
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21982880
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21818138
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20687349
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19777217
56	* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.19133801
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16966120
58	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.16886646
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16549831
60	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.15666712
61	SOX9_26525672_Chip-Seq_HEART_Mouse	1.15103975
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.14863841
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14863841
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14259252
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13960991
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13410502
67	AR_19668381_ChIP-Seq_PC3_Human	1.13270000
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.13238451
69	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.12652167
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12504069
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12400774
72	RXR_22108803_ChIP-Seq_LS180_Human	1.12390097
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12256341
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10024688
75	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.09434907
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07933266
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06935958
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06909528
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04998184
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03678969
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03669899
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.02988556
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02271912
84	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.01794666
85	KDM2B_26808549_Chip-Seq_REH_Human	1.01736492
86	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.00390987
87	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00195096
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99326165
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.99002093
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98915110
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95824804
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95824804
93	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.94971108
94	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.93755123
95	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.93360192
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93081737
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.92646765
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92612786
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.91244898
100	VDR_22108803_ChIP-Seq_LS180_Human	0.90379432

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	2.87538089
2	MP0000569_abnormal_digit_pigmentation	2.53075437
3	MP0000383_abnormal_hair_follicle	2.40005480
4	MP0000427_abnormal_hair_cycle	2.29992712
5	MP0004133_heterotaxia	2.13158757
6	MP0000778_abnormal_nervous_system	2.12539061
7	MP0008877_abnormal_DNA_methylation	1.99548772
8	MP0002638_abnormal_pupillary_reflex	1.98585737
9	MP0010678_abnormal_skin_adnexa	1.85329675
10	MP0005645_abnormal_hypothalamus_physiol	1.82003056
11	MP0003937_abnormal_limbs/digits/tail_de	1.80977317
12	MP0005409_darkened_coat_color	1.75799964
13	MP0005187_abnormal_penis_morphology	1.74426514
14	MP0002009_preneoplasia	1.70164328
15	MP0000537_abnormal_urethra_morphology	1.69022718
16	MP0008057_abnormal_DNA_replication	1.62967241
17	MP0009384_cardiac_valve_regurgitation	1.61536475
18	MP0002102_abnormal_ear_morphology	1.60314815
19	MP0002184_abnormal_innervation	1.58240348
20	MP0005367_renal/urinary_system_phenotyp	1.55125605
21	MP0000516_abnormal_urinary_system	1.55125605
22	MP0000647_abnormal_sebaceous_gland	1.51503224
23	MP0002751_abnormal_autonomic_nervous	1.43924443
24	MP0000631_abnormal_neuroendocrine_gland	1.42597114
25	MP0004043_abnormal_pH_regulation	1.39017202
26	MP0001968_abnormal_touch/_nociception	1.38619312
27	MP0002160_abnormal_reproductive_system	1.36779321
28	MP0003861_abnormal_nervous_system	1.33720451
29	MP0002928_abnormal_bile_duct	1.29399664
30	MP0003935_abnormal_craniofacial_develop	1.29294805
31	MP0003755_abnormal_palate_morphology	1.29065126
32	MP0009250_abnormal_appendicular_skeleto	1.26599389
33	MP0000538_abnormal_urinary_bladder	1.23557814
34	MP0000534_abnormal_ureter_morphology	1.21587456
35	MP0001346_abnormal_lacrimal_gland	1.20163162
36	MP0002822_catalepsy	1.16497531
37	MP0000955_abnormal_spinal_cord	1.14617543
38	MP0001286_abnormal_eye_development	1.12421226
39	MP0006072_abnormal_retinal_apoptosis	1.11763206
40	MP0003942_abnormal_urinary_system	1.10591498
41	MP0003880_abnormal_central_pattern	1.09502484
42	MP0003943_abnormal_hepatobiliary_system	1.08434801
43	MP0002084_abnormal_developmental_patter	1.07728890
44	MP0005503_abnormal_tendon_morphology	1.06861163
45	MP0005551_abnormal_eye_electrophysiolog	1.05783627
46	MP0005386_behavior/neurological_phenoty	1.05597665
47	MP0004924_abnormal_behavior	1.05597665
48	MP0004270_analgesia	1.05296837
49	MP0002697_abnormal_eye_size	1.02784445
50	MP0006276_abnormal_autonomic_nervous	1.01915072
51	MP0005423_abnormal_somatic_nervous	1.01315029
52	MP0000428_abnormal_craniofacial_morphol	0.99137712
53	MP0003121_genomic_imprinting	0.97898349
54	MP0002063_abnormal_learning/memory/cond	0.97730119
55	MP0002152_abnormal_brain_morphology	0.97626971
56	MP0002098_abnormal_vibrissa_morphology	0.96601230
57	MP0002233_abnormal_nose_morphology	0.95794733
58	MP0000013_abnormal_adipose_tissue	0.95273779
59	MP0002752_abnormal_somatic_nervous	0.94657812
60	MP0005076_abnormal_cell_differentiation	0.94652439
61	MP0002557_abnormal_social/conspecific_i	0.92587249
62	MP0002116_abnormal_craniofacial_bone	0.92149928
63	MP0003119_abnormal_digestive_system	0.90131152
64	MP0000432_abnormal_head_morphology	0.89956053
65	MP0002938_white_spotting	0.89819259
66	MP0002081_perinatal_lethality	0.89569241
67	MP0005174_abnormal_tail_pigmentation	0.89497875
68	MP0003385_abnormal_body_wall	0.89212312
69	MP0002882_abnormal_neuron_morphology	0.88825569
70	MP0004197_abnormal_fetal_growth/weight/	0.88296469
71	MP0002572_abnormal_emotion/affect_behav	0.88248611
72	MP0004264_abnormal_extraembryonic_tissu	0.87948177
73	MP0004811_abnormal_neuron_physiology	0.87862810
74	MP0002234_abnormal_pharynx_morphology	0.87857785
75	MP0009703_decreased_birth_body	0.87263535
76	MP0001188_hyperpigmentation	0.86491679
77	MP0005646_abnormal_pituitary_gland	0.86104540
78	MP0002736_abnormal_nociception_after	0.85512662
79	MP0001529_abnormal_vocalization	0.85249618
80	MP0009745_abnormal_behavioral_response	0.83014706
81	MP0001299_abnormal_eye_distance/	0.82641053
82	MP0005083_abnormal_biliary_tract	0.82465235
83	MP0005195_abnormal_posterior_eye	0.82295437
84	MP0002109_abnormal_limb_morphology	0.81779523
85	MP0005389_reproductive_system_phenotype	0.81681015
86	MP0003635_abnormal_synaptic_transmissio	0.80101342
87	MP0003936_abnormal_reproductive_system	0.79400416
88	MP0005253_abnormal_eye_physiology	0.79335303
89	MP0005248_abnormal_Harderian_gland	0.79301692
90	MP0000733_abnormal_muscle_development	0.78945615
91	MP0009046_muscle_twitch	0.78881941
92	MP0005171_absent_coat_pigmentation	0.78173758
93	MP0002085_abnormal_embryonic_tissue	0.77718818
94	MP0002088_abnormal_embryonic_growth/wei	0.77567668
95	MP0003984_embryonic_growth_retardation	0.76985890
96	MP0001672_abnormal_embryogenesis/_devel	0.76518987
97	MP0005380_embryogenesis_phenotype	0.76518987
98	MP0001986_abnormal_taste_sensitivity	0.76007009
99	MP0001486_abnormal_startle_reflex	0.75792596
100	MP0001270_distended_abdomen	0.75645980

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	2.88879778
2	Cerebellar dysplasia (HP:0007033)	2.85069244
3	Chorioretinal atrophy (HP:0000533)	2.70898682
4	Pancreatic cysts (HP:0001737)	2.65341483
5	Abnormality of the nasal septum (HP:0000419)	2.62548370
6	Type II lissencephaly (HP:0007260)	2.55769387
7	Patellar aplasia (HP:0006443)	2.48602535
8	Chronic hepatic failure (HP:0100626)	2.40990439
9	Tubulointerstitial nephritis (HP:0001970)	2.32293928
10	Aplasia/Hypoplasia of the patella (HP:0006498)	2.24775253
11	Renovascular hypertension (HP:0100817)	2.18273777
12	Protruding tongue (HP:0010808)	2.17677974
13	Increased corneal curvature (HP:0100692)	2.16989956
14	Keratoconus (HP:0000563)	2.16989956
15	Gaze-evoked nystagmus (HP:0000640)	2.13639724
16	Lissencephaly (HP:0001339)	2.11930375
17	High anterior hairline (HP:0009890)	2.10256502
18	Pendular nystagmus (HP:0012043)	2.10063690
19	Midline defect of the nose (HP:0004122)	2.09454709
20	Genetic anticipation (HP:0003743)	2.09149563
21	Neoplasm of the adrenal cortex (HP:0100641)	1.97526393
22	Abnormality of the ischium (HP:0003174)	1.97300395
23	Abnormality of the renal medulla (HP:0100957)	1.94822705
24	Hypoplastic ischia (HP:0003175)	1.93329010
25	Abnormality of the pons (HP:0007361)	1.91661813
26	Volvulus (HP:0002580)	1.91194994
27	Neoplasm of the heart (HP:0100544)	1.90970158
28	Fibular aplasia (HP:0002990)	1.88951908
29	Depressed nasal tip (HP:0000437)	1.88582370
30	Cutaneous finger syndactyly (HP:0010554)	1.88402517
31	Fair hair (HP:0002286)	1.87211012
32	Pancreatic fibrosis (HP:0100732)	1.87136385
33	Truncal obesity (HP:0001956)	1.85784778
34	Hypoplasia of the pons (HP:0012110)	1.84755535
35	Abnormality of the 2nd finger (HP:0004100)	1.83143131
36	Abnormality of the parietal bone (HP:0002696)	1.82143901
37	Partial agenesis of the corpus callosum (HP:0001338)	1.81513504
38	Nephronophthisis (HP:0000090)	1.81049096
39	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.80646663
40	Abnormality of the renal cortex (HP:0011035)	1.80100791
41	Pachygyria (HP:0001302)	1.80048819
42	Aqueductal stenosis (HP:0002410)	1.79595075
43	Abnormality of the carotid arteries (HP:0005344)	1.77509738
44	Ectopic kidney (HP:0000086)	1.76096557
45	Non-midline cleft lip (HP:0100335)	1.75546568
46	Narrow palate (HP:0000189)	1.74233647
47	Shawl scrotum (HP:0000049)	1.73867485
48	Obsessive-compulsive behavior (HP:0000722)	1.73010009
49	Drooling (HP:0002307)	1.72893568
50	Cystic liver disease (HP:0006706)	1.71487999
51	Elfin facies (HP:0004428)	1.71180539
52	Chromsome breakage (HP:0040012)	1.70978829
53	Coronal craniosynostosis (HP:0004440)	1.70253651
54	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.69552977
55	Vitreoretinal degeneration (HP:0000655)	1.67998157
56	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.66835223
57	Short 4th metacarpal (HP:0010044)	1.66835223
58	Cutaneous syndactyly (HP:0012725)	1.66009375
59	Glioma (HP:0009733)	1.65988200
60	Progressive inability to walk (HP:0002505)	1.65522511
61	Bony spicule pigmentary retinopathy (HP:0007737)	1.64830822
62	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.64188168
63	Hypoplasia of the brainstem (HP:0002365)	1.64188168
64	Broad-based gait (HP:0002136)	1.62889577
65	Heterotopia (HP:0002282)	1.61684206
66	Clumsiness (HP:0002312)	1.61144721
67	Congenital stationary night blindness (HP:0007642)	1.61070776
68	Tubular atrophy (HP:0000092)	1.61048303
69	Buphthalmos (HP:0000557)	1.60003814
70	Short phalanx of the thumb (HP:0009660)	1.59624741
71	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.59054138
72	Wide intermamillary distance (HP:0006610)	1.57961220
73	Optic nerve hypoplasia (HP:0000609)	1.57870569
74	Aplasia involving forearm bones (HP:0009822)	1.57806218
75	Absent forearm bone (HP:0003953)	1.57806218
76	Abnormality of the aortic arch (HP:0012303)	1.57386476
77	Thick eyebrow (HP:0000574)	1.57290196
78	Absent radius (HP:0003974)	1.56465090
79	Attenuation of retinal blood vessels (HP:0007843)	1.56055687
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.55785990
81	Inability to walk (HP:0002540)	1.55465242
82	Urinary bladder sphincter dysfunction (HP:0002839)	1.55368127
83	Progressive cerebellar ataxia (HP:0002073)	1.54950423
84	Vertebral arch anomaly (HP:0008438)	1.54110224
85	Esophageal atresia (HP:0002032)	1.52460524
86	Intestinal atresia (HP:0011100)	1.52411994
87	Gastrointestinal atresia (HP:0002589)	1.52287693
88	Concave nail (HP:0001598)	1.52150632
89	Spina bifida occulta (HP:0003298)	1.52037156
90	Highly arched eyebrow (HP:0002553)	1.51452867
91	Excessive salivation (HP:0003781)	1.50589638
92	True hermaphroditism (HP:0010459)	1.50140000
93	Shallow orbits (HP:0000586)	1.49813722
94	Abnormality of midbrain morphology (HP:0002418)	1.49724120
95	Molar tooth sign on MRI (HP:0002419)	1.49724120
96	Abnormality of the pubic bones (HP:0003172)	1.49559827
97	Oligodactyly (hands) (HP:0001180)	1.49085873
98	Dysmetric saccades (HP:0000641)	1.48968616
99	Morphological abnormality of the pyramidal tract (HP:0002062)	1.48416335
100	Large eyes (HP:0001090)	1.48088745

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.68508398
2	CASK	3.38741217
3	TLK1	2.78600126
4	MAP3K4	2.73157709
5	MAP2K6	2.50236318
6	MAP2K7	2.31354650
7	ZAK	2.28886737
8	AKT3	1.99202177
9	WNK4	1.97728643
10	STK39	1.93693998
11	MET	1.90625970
12	FGFR2	1.86883326
13	ADRBK2	1.67653236
14	LATS1	1.66253809
15	NUAK1	1.62304597
16	EEF2K	1.55421097
17	ICK	1.49510101
18	CDK12	1.48460976
19	BRD4	1.45443263
20	MAP2K4	1.44628458
21	CAMK1D	1.43043064
22	STK38L	1.42638713
23	PIK3CA	1.42503409
24	MARK1	1.40533681
25	MAPK13	1.39626260
26	CAMK1G	1.39138654
27	OXSR1	1.34742591
28	MKNK2	1.32189685
29	SIK2	1.22850574
30	MAP4K2	1.21592254
31	TAF1	1.20238644
32	PNCK	1.20235729
33	ERBB3	1.16897624
34	SGK2	1.14804170
35	PRKD2	1.14217272
36	TRIB3	1.12026943
37	BCR	1.06726654
38	STK38	1.00530480
39	NTRK3	0.96888188
40	WNK3	0.95811259
41	SRPK1	0.95463300
42	PDGFRB	0.90862866
43	GRK1	0.89331409
44	NTRK2	0.88901217
45	MAP3K7	0.86229406
46	MAPKAPK3	0.85647990
47	BRSK2	0.85202032
48	PAK3	0.81540411
49	RET	0.78243396
50	TAOK2	0.78132895
51	STK3	0.77704576
52	SGK223	0.77686752
53	SGK494	0.77686752
54	FGFR3	0.77624143
55	TSSK6	0.76301980
56	SGK3	0.75581784
57	RPS6KB1	0.72598577
58	TRIM28	0.72209583
59	WNK1	0.71880849
60	PRKAA1	0.71715385
61	MAP3K10	0.71540727
62	KSR1	0.70464233
63	YES1	0.67141984
64	MTOR	0.66459810
65	MELK	0.64683982
66	PDGFRA	0.64642263
67	PRKCE	0.64065366
68	PINK1	0.63773307
69	RPS6KB2	0.58807023
70	PRKD3	0.58075331
71	MAPK11	0.57807435
72	RPS6KA4	0.55241288
73	PRKCH	0.54996081
74	PKN2	0.54172892
75	STK11	0.53851166
76	PRKCZ	0.50721541
77	CSNK1D	0.50283547
78	BMPR1B	0.48379140
79	PRKCG	0.48297994
80	SCYL2	0.47413800
81	NTRK1	0.46942828
82	MST1R	0.46614395
83	EPHA3	0.45400853
84	PRKCI	0.44692756
85	PLK2	0.44521568
86	DYRK1A	0.42842901
87	MAP2K2	0.42403072
88	CAMKK1	0.42132841
89	ERBB4	0.42043474
90	MAP2K1	0.39596443
91	DAPK2	0.39105844
92	ATR	0.38766237
93	INSRR	0.38222731
94	ATM	0.37876460
95	NEK2	0.37735246
96	TGFBR1	0.37624203
97	FER	0.37028720
98	PASK	0.36902308
99	CAMK4	0.36391488
100	NEK9	0.35470871

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	2.03988215
2	Nicotine addiction_Homo sapiens_hsa05033	1.81963548
3	Basal transcription factors_Homo sapiens_hsa03022	1.69804138
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.57261347
5	Axon guidance_Homo sapiens_hsa04360	1.54614962
6	Regulation of autophagy_Homo sapiens_hsa04140	1.47393009
7	Lysine degradation_Homo sapiens_hsa00310	1.47056863
8	ErbB signaling pathway_Homo sapiens_hsa04012	1.46446938
9	mTOR signaling pathway_Homo sapiens_hsa04150	1.42841842
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42722777
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.41257084
12	Taste transduction_Homo sapiens_hsa04742	1.40568231
13	Hippo signaling pathway_Homo sapiens_hsa04390	1.36882334
14	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.35553303
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.33648672
16	Basal cell carcinoma_Homo sapiens_hsa05217	1.32348677
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.27931000
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26664880
19	Phototransduction_Homo sapiens_hsa04744	1.24323868
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.20206135
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18211605
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16541537
23	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.14456814
24	Morphine addiction_Homo sapiens_hsa05032	1.13999544
25	Endometrial cancer_Homo sapiens_hsa05213	1.13955998
26	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.09691570
27	MicroRNAs in cancer_Homo sapiens_hsa05206	1.09615551
28	Prolactin signaling pathway_Homo sapiens_hsa04917	1.09250481
29	Alcoholism_Homo sapiens_hsa05034	1.08790503
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.07446673
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07086865
32	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.06298379
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06217073
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05178950
35	Long-term depression_Homo sapiens_hsa04730	1.03386119
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01193257
37	GABAergic synapse_Homo sapiens_hsa04727	1.00340297
38	Insulin secretion_Homo sapiens_hsa04911	1.00104919
39	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.99085796
40	Butanoate metabolism_Homo sapiens_hsa00650	0.98962358
41	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.98920182
42	Circadian entrainment_Homo sapiens_hsa04713	0.98540577
43	ABC transporters_Homo sapiens_hsa02010	0.98157549
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97450050
45	Renal cell carcinoma_Homo sapiens_hsa05211	0.97256854
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.96883524
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95259987
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.92455490
49	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92110454
50	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.91927714
51	Melanoma_Homo sapiens_hsa05218	0.90435037
52	RNA degradation_Homo sapiens_hsa03018	0.88580633
53	Cholinergic synapse_Homo sapiens_hsa04725	0.87224200
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.85691526
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85589877
56	Glioma_Homo sapiens_hsa05214	0.85366147
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84893112
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.84114801
59	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.83607021
60	FoxO signaling pathway_Homo sapiens_hsa04068	0.83380065
61	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.82386532
62	Prostate cancer_Homo sapiens_hsa05215	0.80812710
63	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80214057
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.79615196
65	Small cell lung cancer_Homo sapiens_hsa05222	0.79246875
66	Tight junction_Homo sapiens_hsa04530	0.78734839
67	Adherens junction_Homo sapiens_hsa04520	0.78712801
68	Estrogen signaling pathway_Homo sapiens_hsa04915	0.78464940
69	Circadian rhythm_Homo sapiens_hsa04710	0.78449736
70	Thyroid cancer_Homo sapiens_hsa05216	0.77529181
71	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.77378494
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77331481
73	Melanogenesis_Homo sapiens_hsa04916	0.77087815
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.75622772
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.75203232
76	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73855249
77	Colorectal cancer_Homo sapiens_hsa05210	0.72479977
78	Ras signaling pathway_Homo sapiens_hsa04014	0.71734743
79	GnRH signaling pathway_Homo sapiens_hsa04912	0.71480456
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.71105720
81	Notch signaling pathway_Homo sapiens_hsa04330	0.70551340
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69102811
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.67564003
84	Homologous recombination_Homo sapiens_hsa03440	0.67492227
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.67377527
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66731505
87	Salivary secretion_Homo sapiens_hsa04970	0.66720276
88	Focal adhesion_Homo sapiens_hsa04510	0.66380908
89	One carbon pool by folate_Homo sapiens_hsa00670	0.66313586
90	Insulin resistance_Homo sapiens_hsa04931	0.66250601
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65769509
92	Serotonergic synapse_Homo sapiens_hsa04726	0.64905794
93	Cocaine addiction_Homo sapiens_hsa05030	0.64899949
94	Proteoglycans in cancer_Homo sapiens_hsa05205	0.63477495
95	Pathways in cancer_Homo sapiens_hsa05200	0.63170270
96	Non-small cell lung cancer_Homo sapiens_hsa05223	0.63106277
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62415487
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61703400
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.60344867
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60330602

ZNF623

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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