ZNF625-ZNF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 625 (ZNF625) and zinc finger protein 20 (ZNF20) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)4.45244734
2DNA double-strand break processing (GO:0000729)4.41813819
3intraciliary transport (GO:0042073)4.31945542
4DNA ligation (GO:0006266)4.21624587
5regulation of DNA endoreduplication (GO:0032875)4.13401658
6microtubule depolymerization (GO:0007019)4.11671406
7chromatin remodeling at centromere (GO:0031055)4.05384892
8kinetochore assembly (GO:0051382)4.04552715
9CENP-A containing nucleosome assembly (GO:0034080)3.94469291
10metaphase plate congression (GO:0051310)3.93841525
11kinetochore organization (GO:0051383)3.88910893
12histone H2A acetylation (GO:0043968)3.72841102
13histone exchange (GO:0043486)3.65146029
14negative regulation of DNA recombination (GO:0045910)3.59323332
15establishment of integrated proviral latency (GO:0075713)3.58276888
16nonmotile primary cilium assembly (GO:0035058)3.57020705
17resolution of meiotic recombination intermediates (GO:0000712)3.54674573
18presynaptic membrane assembly (GO:0097105)3.53990565
19cilium movement (GO:0003341)3.53117244
20regulation of meiosis I (GO:0060631)3.46745025
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.46535836
22regulation of mitotic spindle checkpoint (GO:1903504)3.42101778
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42101778
24attachment of spindle microtubules to kinetochore (GO:0008608)3.39965006
25centriole replication (GO:0007099)3.32874169
26double-strand break repair via nonhomologous end joining (GO:0006303)3.28791702
27non-recombinational repair (GO:0000726)3.28791702
28protein localization to kinetochore (GO:0034501)3.28678993
29cilium organization (GO:0044782)3.22194933
30presynaptic membrane organization (GO:0097090)3.22129383
31mitotic metaphase plate congression (GO:0007080)3.21761549
32positive regulation of male gonad development (GO:2000020)3.21604840
33cilium assembly (GO:0042384)3.21098861
34replication fork processing (GO:0031297)3.19007867
35DNA replication-independent nucleosome organization (GO:0034724)3.18202458
36DNA replication-independent nucleosome assembly (GO:0006336)3.18202458
37microtubule polymerization or depolymerization (GO:0031109)3.17358315
38regulation of timing of cell differentiation (GO:0048505)3.16725934
39olfactory bulb development (GO:0021772)3.13032941
40protein neddylation (GO:0045116)3.11186581
41regulation of development, heterochronic (GO:0040034)3.11090810
42regulation of helicase activity (GO:0051095)3.08873307
43pyrimidine nucleobase catabolic process (GO:0006208)3.08805144
44negative regulation of meiosis (GO:0045835)3.08273823
45establishment of chromosome localization (GO:0051303)3.06379512
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03861494
47ganglion development (GO:0061548)2.98940404
48cilium morphogenesis (GO:0060271)2.98845410
49protein localization to chromosome, centromeric region (GO:0071459)2.95218776
50establishment of viral latency (GO:0019043)2.93350194
51DNA damage response, detection of DNA damage (GO:0042769)2.88689996
52regulation of centriole replication (GO:0046599)2.86060763
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81929961
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81929961
55negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81929961
56negative regulation of mitotic sister chromatid separation (GO:2000816)2.81929961
57negative regulation of sister chromatid segregation (GO:0033046)2.81929961
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81706025
59regulation of male gonad development (GO:2000018)2.81693001
60regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77634039
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77634039
62regulation of cilium movement (GO:0003352)2.77438206
63mitotic spindle checkpoint (GO:0071174)2.77079710
64spindle checkpoint (GO:0031577)2.75805480
65cullin deneddylation (GO:0010388)2.75033982
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74460263
67proteasome assembly (GO:0043248)2.73269185
68negative regulation of membrane potential (GO:0045837)2.71805260
69neural tube formation (GO:0001841)2.71506329
70negative regulation of chromosome segregation (GO:0051985)2.70261142
71DNA catabolic process, exonucleolytic (GO:0000738)2.69649443
72sequestering of actin monomers (GO:0042989)2.68048564
73DNA strand renaturation (GO:0000733)2.67188375
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66062181
75centriole assembly (GO:0098534)2.64772917
76synapsis (GO:0007129)2.64071569
77sympathetic nervous system development (GO:0048485)2.63007894
78regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60021537
79ATP-dependent chromatin remodeling (GO:0043044)2.58669685
80regulation of mitotic sister chromatid separation (GO:0010965)2.56954506
81regulation of mitotic sister chromatid segregation (GO:0033047)2.56954506
82regulation of sister chromatid segregation (GO:0033045)2.56954506
83organelle disassembly (GO:1903008)2.56521288
84protein polyglutamylation (GO:0018095)2.56081266
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55836605
86mitotic spindle organization (GO:0007052)2.55484247
87retinal ganglion cell axon guidance (GO:0031290)2.55257005
88regulation of telomere maintenance via telomerase (GO:0032210)2.54392503
89forebrain neuron differentiation (GO:0021879)2.53848279
90transmission of nerve impulse (GO:0019226)2.53198864
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53179258
92histone mRNA metabolic process (GO:0008334)2.53157771
93axonemal dynein complex assembly (GO:0070286)2.52107393
94cholesterol biosynthetic process (GO:0006695)2.51294617
95mitotic spindle assembly checkpoint (GO:0007094)2.50824213
96recombinational repair (GO:0000725)2.50017692
97regulation of feeding behavior (GO:0060259)2.48938032
98regulation of sister chromatid cohesion (GO:0007063)2.46905911
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46807058
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46807058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80267742
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56474498
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.27833713
4ZNF274_21170338_ChIP-Seq_K562_Hela3.27129248
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.92932943
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.83715812
7ELK1_19687146_ChIP-ChIP_HELA_Human2.64579827
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63660044
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54906215
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44587990
11IGF1R_20145208_ChIP-Seq_DFB_Human2.39707711
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30063604
13EWS_26573619_Chip-Seq_HEK293_Human2.28633554
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27997777
15FUS_26573619_Chip-Seq_HEK293_Human2.19885626
16TAF15_26573619_Chip-Seq_HEK293_Human2.19160684
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15794133
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.14454848
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03165467
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00396881
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00201941
22P300_19829295_ChIP-Seq_ESCs_Human1.98223424
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95720635
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91907704
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91057562
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87310322
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80525987
28VDR_22108803_ChIP-Seq_LS180_Human1.79489046
29VDR_23849224_ChIP-Seq_CD4+_Human1.77069061
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74121320
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73067150
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66543475
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.61740269
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53975250
35GBX2_23144817_ChIP-Seq_PC3_Human1.53315830
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51055522
37FOXP3_21729870_ChIP-Seq_TREG_Human1.50574435
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50380137
39MYC_18940864_ChIP-ChIP_HL60_Human1.49764180
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.49762440
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41969320
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37879350
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36870231
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.35941030
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35053533
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.34628770
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.34265710
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31555575
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.27721684
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27340310
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26673549
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26673549
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25635086
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24205603
55RNF2_27304074_Chip-Seq_NSC_Mouse1.23257991
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22772906
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22206771
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21633338
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17611574
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16930068
61GABP_19822575_ChIP-Seq_HepG2_Human1.15767985
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.15745236
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15440934
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15440934
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15440934
66ER_23166858_ChIP-Seq_MCF-7_Human1.15261217
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.14977402
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14293815
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14249444
70SMAD4_21799915_ChIP-Seq_A2780_Human1.13872908
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13202492
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13008950
73IRF1_19129219_ChIP-ChIP_H3396_Human1.12705518
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12234115
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11786083
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.09206461
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08701468
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07925853
79TTF2_22483619_ChIP-Seq_HELA_Human1.06605660
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06002802
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.05809228
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04623816
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.04416986
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04310567
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03109864
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03057600
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03056335
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02920776
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02760260
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01466193
91DCP1A_22483619_ChIP-Seq_HELA_Human1.01439790
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00300754
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00123174
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.99830851
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98960293
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98762399
97AR_21909140_ChIP-Seq_LNCAP_Human0.97431953
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97119939
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96750503
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.96213636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.29829280
2MP0008789_abnormal_olfactory_epithelium3.36964170
3MP0006072_abnormal_retinal_apoptosis3.06288004
4MP0002653_abnormal_ependyma_morphology2.96907615
5MP0008877_abnormal_DNA_methylation2.89121723
6MP0005499_abnormal_olfactory_system2.86069936
7MP0005394_taste/olfaction_phenotype2.86069936
8MP0001529_abnormal_vocalization2.77027553
9MP0003122_maternal_imprinting2.65480142
10MP0002102_abnormal_ear_morphology2.62353265
11MP0003136_yellow_coat_color2.44022085
12MP0006292_abnormal_olfactory_placode2.39530483
13MP0008058_abnormal_DNA_repair2.39329360
14MP0005253_abnormal_eye_physiology2.37849471
15MP0010094_abnormal_chromosome_stability2.35304583
16MP0003890_abnormal_embryonic-extraembry2.31242674
17MP0003121_genomic_imprinting2.21324173
18MP0000372_irregular_coat_pigmentation2.04386740
19MP0002751_abnormal_autonomic_nervous2.03260074
20MP0006276_abnormal_autonomic_nervous1.91671396
21MP0003011_delayed_dark_adaptation1.88591739
22MP0002938_white_spotting1.82732778
23MP0001293_anophthalmia1.82004888
24MP0003787_abnormal_imprinting1.81159494
25MP0000778_abnormal_nervous_system1.74906344
26MP0004133_heterotaxia1.74406536
27MP0005367_renal/urinary_system_phenotyp1.65209723
28MP0000516_abnormal_urinary_system1.65209723
29MP0003693_abnormal_embryo_hatching1.61812513
30MP0002233_abnormal_nose_morphology1.57535273
31MP0003567_abnormal_fetal_cardiomyocyte1.56490428
32MP0001485_abnormal_pinna_reflex1.55281401
33MP0001984_abnormal_olfaction1.49917626
34MP0005391_vision/eye_phenotype1.45787818
35MP0003718_maternal_effect1.45020707
36MP0002638_abnormal_pupillary_reflex1.39936888
37MP0000049_abnormal_middle_ear1.36721631
38MP0003937_abnormal_limbs/digits/tail_de1.33262181
39MP0005551_abnormal_eye_electrophysiolog1.32505574
40MP0009697_abnormal_copulation1.30568598
41MP0008932_abnormal_embryonic_tissue1.30415380
42MP0003077_abnormal_cell_cycle1.28190050
43MP0004215_abnormal_myocardial_fiber1.20014166
44MP0001929_abnormal_gametogenesis1.17372341
45MP0002254_reproductive_system_inflammat1.17120045
46MP0003755_abnormal_palate_morphology1.14441527
47MP0002210_abnormal_sex_determination1.12629963
48MP0004957_abnormal_blastocyst_morpholog1.12396943
49MP0001177_atelectasis1.12023414
50MP0001286_abnormal_eye_development1.11498873
51MP0003111_abnormal_nucleus_morphology1.11085074
52MP0000647_abnormal_sebaceous_gland1.09495114
53MP0003186_abnormal_redox_activity1.08887303
54MP0001188_hyperpigmentation1.08577259
55MP0000631_abnormal_neuroendocrine_gland1.04870489
56MP0006054_spinal_hemorrhage1.04628214
57MP0005248_abnormal_Harderian_gland1.03749240
58MP0003861_abnormal_nervous_system1.02897319
59MP0005195_abnormal_posterior_eye1.02529233
60MP0008007_abnormal_cellular_replicative1.02386803
61MP0002837_dystrophic_cardiac_calcinosis1.02016699
62MP0001324_abnormal_eye_pigmentation0.99706484
63MP0002736_abnormal_nociception_after0.98802856
64MP0001145_abnormal_male_reproductive0.98708088
65MP0000653_abnormal_sex_gland0.97686921
66MP0003698_abnormal_male_reproductive0.93204547
67MP0006035_abnormal_mitochondrial_morpho0.92540372
68MP0003315_abnormal_perineum_morphology0.92478442
69MP0002752_abnormal_somatic_nervous0.91380463
70MP0002090_abnormal_vision0.89850676
71MP0003221_abnormal_cardiomyocyte_apopto0.88976442
72MP0000569_abnormal_digit_pigmentation0.87967013
73MP0002234_abnormal_pharynx_morphology0.87852454
74MP0005084_abnormal_gallbladder_morpholo0.86782002
75MP0000955_abnormal_spinal_cord0.86010013
76MP0002095_abnormal_skin_pigmentation0.85869215
77MP0004142_abnormal_muscle_tone0.84956272
78MP0008995_early_reproductive_senescence0.84942816
79MP0001764_abnormal_homeostasis0.83981674
80MP0001486_abnormal_startle_reflex0.83128291
81MP0000026_abnormal_inner_ear0.82798612
82MP0002152_abnormal_brain_morphology0.81551542
83MP0001119_abnormal_female_reproductive0.80342650
84MP0002557_abnormal_social/conspecific_i0.79697151
85MP0004197_abnormal_fetal_growth/weight/0.78403471
86MP0002184_abnormal_innervation0.75694089
87MP0003786_premature_aging0.75362756
88MP0003385_abnormal_body_wall0.74552551
89MP0009703_decreased_birth_body0.74330898
90MP0002111_abnormal_tail_morphology0.73886494
91MP0003938_abnormal_ear_development0.73717120
92MP0002928_abnormal_bile_duct0.73557493
93MP0002092_abnormal_eye_morphology0.72487550
94MP0002282_abnormal_trachea_morphology0.72176780
95MP0005085_abnormal_gallbladder_physiolo0.70524428
96MP0002882_abnormal_neuron_morphology0.67710326
97MP0005197_abnormal_uvea_morphology0.67697311
98MP0003119_abnormal_digestive_system0.67565813
99MP0002697_abnormal_eye_size0.67534852
100MP0002085_abnormal_embryonic_tissue0.67468813

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.13803901
2Pancreatic fibrosis (HP:0100732)3.99184167
3Pancreatic cysts (HP:0001737)3.90849516
4Medial flaring of the eyebrow (HP:0010747)3.87027362
5Congenital primary aphakia (HP:0007707)3.85437479
6Gait imbalance (HP:0002141)3.81667064
7Abnormality of midbrain morphology (HP:0002418)3.63058382
8Molar tooth sign on MRI (HP:0002419)3.63058382
9Nephrogenic diabetes insipidus (HP:0009806)3.62059779
10Abnormality of the labia minora (HP:0012880)3.28259940
11Hypoplastic pelvis (HP:0008839)3.17383819
12Nephronophthisis (HP:0000090)3.14084954
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97431783
14Vaginal atresia (HP:0000148)2.91976883
15Genital tract atresia (HP:0001827)2.91405683
16Hyperglycinemia (HP:0002154)2.91001368
17Aplasia/Hypoplasia of the tongue (HP:0010295)2.90659614
18Postaxial foot polydactyly (HP:0001830)2.82462503
19Postaxial hand polydactyly (HP:0001162)2.78919273
20Sclerocornea (HP:0000647)2.77579895
21Volvulus (HP:0002580)2.73108311
22Chronic hepatic failure (HP:0100626)2.66494353
23Cystic liver disease (HP:0006706)2.65191072
24Anencephaly (HP:0002323)2.59316301
25Oligodactyly (hands) (HP:0001180)2.58576271
26Preaxial hand polydactyly (HP:0001177)2.55929525
27Meckel diverticulum (HP:0002245)2.55739723
28Abnormality of the renal medulla (HP:0100957)2.55516415
29Intestinal atresia (HP:0011100)2.51492749
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.49254412
31Poor coordination (HP:0002370)2.47959237
32Abnormality of the ileum (HP:0001549)2.47871387
33Abnormality of chromosome stability (HP:0003220)2.47326674
34Abnormal respiratory motile cilium physiology (HP:0012261)2.46404412
35Broad foot (HP:0001769)2.44551550
36Acute necrotizing encephalopathy (HP:0006965)2.44348129
37Colon cancer (HP:0003003)2.42213771
38Cortical dysplasia (HP:0002539)2.41430034
39Occipital encephalocele (HP:0002085)2.38522628
40Hyperglycinuria (HP:0003108)2.34002522
41Pendular nystagmus (HP:0012043)2.30028393
42Acute encephalopathy (HP:0006846)2.27715891
43Abnormal ciliary motility (HP:0012262)2.26213345
44Abnormal respiratory epithelium morphology (HP:0012253)2.25322670
45Abnormal respiratory motile cilium morphology (HP:0005938)2.25322670
46Septo-optic dysplasia (HP:0100842)2.25155834
47Sloping forehead (HP:0000340)2.24882584
48Specific learning disability (HP:0001328)2.23884684
49Decreased testicular size (HP:0008734)2.23587617
50Abnormality of glycine metabolism (HP:0010895)2.23160157
51Abnormality of serine family amino acid metabolism (HP:0010894)2.23160157
52Rhinitis (HP:0012384)2.21612010
53Aganglionic megacolon (HP:0002251)2.17020826
54Lipid accumulation in hepatocytes (HP:0006561)2.15394619
55Renal hypoplasia (HP:0000089)2.13066097
56Narrow forehead (HP:0000341)2.12694455
57Hemivertebrae (HP:0002937)2.11677892
58Abolished electroretinogram (ERG) (HP:0000550)2.11054609
59Abnormal mitochondria in muscle tissue (HP:0008316)2.09023569
60Astigmatism (HP:0000483)2.08510527
61Methylmalonic acidemia (HP:0002912)2.07569646
62Progressive macrocephaly (HP:0004481)2.07237179
63Increased hepatocellular lipid droplets (HP:0006565)2.06663827
64Bile duct proliferation (HP:0001408)2.06189273
65Abnormal biliary tract physiology (HP:0012439)2.06189273
66Adactyly (HP:0009776)2.05927688
67Short tibia (HP:0005736)2.05867087
68Lissencephaly (HP:0001339)2.05644368
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.05404649
70Optic nerve hypoplasia (HP:0000609)2.04903858
71Congenital hepatic fibrosis (HP:0002612)2.03451416
72Retinal dysplasia (HP:0007973)2.03394476
73Supernumerary spleens (HP:0009799)2.02640534
74Dandy-Walker malformation (HP:0001305)2.01608468
75Type II lissencephaly (HP:0007260)2.00580280
76Aplasia involving forearm bones (HP:0009822)2.00530965
77Absent forearm bone (HP:0003953)2.00530965
78Oligodactyly (HP:0012165)1.98891556
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97633470
80Male pseudohermaphroditism (HP:0000037)1.96393984
81Mitochondrial inheritance (HP:0001427)1.96318364
82Abnormal lung lobation (HP:0002101)1.92928788
83Papillary thyroid carcinoma (HP:0002895)1.92373970
84Abnormality of the duodenum (HP:0002246)1.89825979
85Abnormal hair whorl (HP:0010721)1.85530824
86Oculomotor apraxia (HP:0000657)1.84796211
87Aplasia/Hypoplasia of the lens (HP:0008063)1.84346063
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83837458
89Micropenis (HP:0000054)1.83786568
90Small intestinal stenosis (HP:0012848)1.83109147
91Duodenal stenosis (HP:0100867)1.83109147
92Multicystic kidney dysplasia (HP:0000003)1.81892702
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.81474213
94Absent/shortened dynein arms (HP:0200106)1.81474213
95Increased corneal curvature (HP:0100692)1.79257396
96Keratoconus (HP:0000563)1.79257396
97Anophthalmia (HP:0000528)1.79162332
98Fibular aplasia (HP:0002990)1.78353359
99Increased CSF lactate (HP:0002490)1.78182494
100Tubulointerstitial nephritis (HP:0001970)1.76368433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.01611433
2TRIM282.83142252
3BCR2.77082689
4NEK12.72258991
5BMPR1B2.60226347
6BUB12.54242786
7WEE12.42893747
8MKNK22.32133383
9MAPK132.28052565
10SRPK12.24425795
11MST42.10308735
12PLK42.09786174
13PLK32.02353102
14NUAK12.01510129
15MKNK11.98082271
16BRSK21.89880841
17CASK1.87823290
18MAP4K21.83704307
19TNIK1.81074184
20TTK1.70446642
21ERBB31.68697629
22CDC71.64127393
23MAP3K41.62498501
24EIF2AK31.58707233
25ZAK1.55028691
26CSNK1G11.54474197
27CDK191.53210496
28PLK11.52004688
29DYRK21.50062410
30DYRK31.49538979
31CSNK1G21.48645911
32BCKDK1.47668891
33CSNK1G31.44790662
34MAP2K71.42298206
35TSSK61.41796607
36PLK21.39367289
37ACVR1B1.37407401
38FRK1.36769554
39PBK1.34241589
40CCNB11.28773948
41PKN11.23314452
42VRK21.19522154
43VRK11.17250274
44PNCK1.15755583
45MARK11.10679822
46STK161.10503086
47PAK31.05689664
48GRK11.04396794
49BRSK11.03449172
50CSNK1A1L0.99883452
51DYRK1B0.97838727
52STK38L0.97739863
53EPHA40.93493762
54UHMK10.91403043
55PINK10.90143494
56BRD40.88285173
57CHEK20.87357550
58ATR0.87110839
59ATM0.77149961
60TGFBR10.76595825
61AURKB0.71940311
62EPHA30.70172267
63CDK30.67946918
64PRKCG0.66909938
65ADRBK20.66633376
66STK30.65558942
67NEK20.62129627
68RPS6KA40.59970536
69ERBB40.59300488
70EIF2AK10.57338296
71YES10.57275161
72EIF2AK20.53798456
73NME10.53382775
74STK100.51523738
75MINK10.51065232
76TAF10.50160589
77PRKCE0.49200196
78DYRK1A0.47735074
79CSNK2A10.46707117
80SIK30.46624320
81CHEK10.46324600
82ERBB20.45830935
83CDK90.44412804
84CSNK1A10.43332971
85CDK80.41512540
86IRAK10.40500908
87INSRR0.38792685
88CDK140.38697839
89CAMK2A0.37896511
90PRKACB0.37626632
91ADRBK10.35032363
92STK240.34708396
93AURKA0.34182725
94MAPK150.32424421
95CDK180.32423474
96CDK10.32256954
97PRKDC0.31630342
98ROCK20.31420556
99TNK20.27413096
100PRKCI0.26489383

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.74115412
2Non-homologous end-joining_Homo sapiens_hsa034503.59759057
3Steroid biosynthesis_Homo sapiens_hsa001003.14201813
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87971235
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60579390
6Proteasome_Homo sapiens_hsa030502.56712714
7Homologous recombination_Homo sapiens_hsa034402.46911496
8Fanconi anemia pathway_Homo sapiens_hsa034602.43876021
9Propanoate metabolism_Homo sapiens_hsa006402.29424065
10Mismatch repair_Homo sapiens_hsa034302.27888363
11Basal transcription factors_Homo sapiens_hsa030222.25770743
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15631196
13Oxidative phosphorylation_Homo sapiens_hsa001902.07497587
14Parkinsons disease_Homo sapiens_hsa050121.99946838
15RNA degradation_Homo sapiens_hsa030181.95372860
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88646073
17Base excision repair_Homo sapiens_hsa034101.85446195
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83841777
19Spliceosome_Homo sapiens_hsa030401.82961005
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82036080
21RNA polymerase_Homo sapiens_hsa030201.81116324
22RNA transport_Homo sapiens_hsa030131.78043331
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77111709
24Fatty acid elongation_Homo sapiens_hsa000621.61979805
25Cell cycle_Homo sapiens_hsa041101.59807226
26Huntingtons disease_Homo sapiens_hsa050161.55959595
27DNA replication_Homo sapiens_hsa030301.48693561
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.46316330
29Nucleotide excision repair_Homo sapiens_hsa034201.44030326
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.39315333
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36126614
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35503622
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33010295
34Phototransduction_Homo sapiens_hsa047441.26077754
35Butanoate metabolism_Homo sapiens_hsa006501.23173418
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21127376
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19988723
38Peroxisome_Homo sapiens_hsa041461.18694220
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16154037
40Hedgehog signaling pathway_Homo sapiens_hsa043401.15892823
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14970009
42Basal cell carcinoma_Homo sapiens_hsa052171.12589823
43Oocyte meiosis_Homo sapiens_hsa041141.06620496
44Collecting duct acid secretion_Homo sapiens_hsa049661.03405809
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97483161
46mRNA surveillance pathway_Homo sapiens_hsa030150.97477376
47Alzheimers disease_Homo sapiens_hsa050100.97259092
48p53 signaling pathway_Homo sapiens_hsa041150.93637881
49Pyrimidine metabolism_Homo sapiens_hsa002400.92797597
50Glutathione metabolism_Homo sapiens_hsa004800.92691639
51Pyruvate metabolism_Homo sapiens_hsa006200.90914336
52Fatty acid metabolism_Homo sapiens_hsa012120.90287951
53Selenocompound metabolism_Homo sapiens_hsa004500.87195036
54Regulation of autophagy_Homo sapiens_hsa041400.84227242
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82360412
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81397578
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80321471
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78272623
59Hippo signaling pathway_Homo sapiens_hsa043900.76164167
60Purine metabolism_Homo sapiens_hsa002300.76157892
61Tryptophan metabolism_Homo sapiens_hsa003800.74641839
62Nitrogen metabolism_Homo sapiens_hsa009100.74155685
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73800000
64Metabolic pathways_Homo sapiens_hsa011000.73586215
65Nicotine addiction_Homo sapiens_hsa050330.72489541
66Fatty acid degradation_Homo sapiens_hsa000710.72425156
67Carbon metabolism_Homo sapiens_hsa012000.71348306
68beta-Alanine metabolism_Homo sapiens_hsa004100.70026672
69One carbon pool by folate_Homo sapiens_hsa006700.61745230
70Ether lipid metabolism_Homo sapiens_hsa005650.59519347
71Folate biosynthesis_Homo sapiens_hsa007900.53113479
72Biosynthesis of amino acids_Homo sapiens_hsa012300.51829170
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51125424
74Caffeine metabolism_Homo sapiens_hsa002320.50540840
75Wnt signaling pathway_Homo sapiens_hsa043100.47781196
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47637674
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47526620
78Retinol metabolism_Homo sapiens_hsa008300.46929440
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46205944
80Arginine and proline metabolism_Homo sapiens_hsa003300.45442612
81Taste transduction_Homo sapiens_hsa047420.45397212
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44859008
83Axon guidance_Homo sapiens_hsa043600.43941521
84TGF-beta signaling pathway_Homo sapiens_hsa043500.42274324
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41316673
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40284402
87Vitamin B6 metabolism_Homo sapiens_hsa007500.39973939
88Olfactory transduction_Homo sapiens_hsa047400.39604993
89Sulfur metabolism_Homo sapiens_hsa009200.37256913
90Cardiac muscle contraction_Homo sapiens_hsa042600.36801598
91Vitamin digestion and absorption_Homo sapiens_hsa049770.36272625
92Chemical carcinogenesis_Homo sapiens_hsa052040.33900574
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28526479
94Alcoholism_Homo sapiens_hsa050340.25296916
95Arachidonic acid metabolism_Homo sapiens_hsa005900.24575965
96Lysine degradation_Homo sapiens_hsa003100.24084043
97Legionellosis_Homo sapiens_hsa051340.22427390
98Ribosome_Homo sapiens_hsa030100.21233721
99Circadian rhythm_Homo sapiens_hsa047100.20753138
100Linoleic acid metabolism_Homo sapiens_hsa005910.19984358

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