ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.31544027
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03401739
3	L-fucose catabolic process (GO:0042355)	3.86576363
4	fucose catabolic process (GO:0019317)	3.86576363
5	L-fucose metabolic process (GO:0042354)	3.86576363
6	platelet dense granule organization (GO:0060155)	3.51972594
7	epithelial cilium movement (GO:0003351)	3.46851472
8	neural tube formation (GO:0001841)	3.46711834
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.38575411
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.34817300
11	retinal cone cell development (GO:0046549)	3.30186759
12	DNA double-strand break processing (GO:0000729)	3.29588672
13	kidney morphogenesis (GO:0060993)	3.28386619
14	regulation of meiosis I (GO:0060631)	3.27207391
15	presynaptic membrane assembly (GO:0097105)	3.23326893
16	limb bud formation (GO:0060174)	3.16028930
17	respiratory chain complex IV assembly (GO:0008535)	3.15647446
18	DNA deamination (GO:0045006)	3.08126426
19	axoneme assembly (GO:0035082)	3.06702446
20	tryptophan catabolic process (GO:0006569)	3.05534134
21	indole-containing compound catabolic process (GO:0042436)	3.05534134
22	indolalkylamine catabolic process (GO:0046218)	3.05534134
23	response to pheromone (GO:0019236)	3.03017636
24	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.01296441
25	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.01296441
26	regulation of translation, ncRNA-mediated (GO:0045974)	3.01296441
27	nonmotile primary cilium assembly (GO:0035058)	2.99296411
28	protein complex biogenesis (GO:0070271)	2.98531175
29	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.97172928
30	pyrimidine nucleobase catabolic process (GO:0006208)	2.97040899
31	presynaptic membrane organization (GO:0097090)	2.96671904
32	otic vesicle formation (GO:0030916)	2.96530975
33	indolalkylamine metabolic process (GO:0006586)	2.94484512
34	cilium morphogenesis (GO:0060271)	2.93563893
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93491672
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93491672
37	NADH dehydrogenase complex assembly (GO:0010257)	2.93491672
38	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.90693803
39	protein localization to cilium (GO:0061512)	2.88877102
40	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87456462
41	piRNA metabolic process (GO:0034587)	2.83079733
42	protein polyglutamylation (GO:0018095)	2.82430709
43	kynurenine metabolic process (GO:0070189)	2.82158414
44	replication fork processing (GO:0031297)	2.81684509
45	cilium movement (GO:0003341)	2.81614552
46	regulation of cilium movement (GO:0003352)	2.80680152
47	negative regulation of telomere maintenance (GO:0032205)	2.80614715
48	dopamine transport (GO:0015872)	2.80368562
49	cytochrome complex assembly (GO:0017004)	2.78890279
50	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.77537027
51	regulation of hexokinase activity (GO:1903299)	2.76738678
52	regulation of glucokinase activity (GO:0033131)	2.76738678
53	peptidyl-histidine modification (GO:0018202)	2.75583925
54	protein-cofactor linkage (GO:0018065)	2.75108798
55	regulation of collateral sprouting (GO:0048670)	2.74346920
56	centriole replication (GO:0007099)	2.73673776
57	mannosylation (GO:0097502)	2.71343298
58	detection of light stimulus involved in visual perception (GO:0050908)	2.70445364
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.70445364
60	cilium organization (GO:0044782)	2.68741059
61	photoreceptor cell development (GO:0042461)	2.66780076
62	intraciliary transport (GO:0042073)	2.66265008
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65829052
64	regulation of action potential (GO:0098900)	2.63180063
65	photoreceptor cell maintenance (GO:0045494)	2.62711118
66	somite development (GO:0061053)	2.62354106
67	inner ear receptor stereocilium organization (GO:0060122)	2.61073072
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60098195
69	cilium assembly (GO:0042384)	2.59825423
70	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.57546759
71	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.57546759
72	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.57172437
73	reflex (GO:0060004)	2.56910180
74	tryptophan metabolic process (GO:0006568)	2.56459412
75	nucleobase catabolic process (GO:0046113)	2.55628952
76	cellular ketone body metabolic process (GO:0046950)	2.55296011
77	prenylation (GO:0097354)	2.54454443
78	protein prenylation (GO:0018342)	2.54454443
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.54268895
80	neuronal action potential (GO:0019228)	2.52438136
81	behavioral response to ethanol (GO:0048149)	2.51953609
82	recombinational repair (GO:0000725)	2.50977871
83	sulfation (GO:0051923)	2.49694073
84	double-strand break repair via homologous recombination (GO:0000724)	2.49196541
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48914469
86	rhodopsin mediated signaling pathway (GO:0016056)	2.48851589
87	negative regulation of mast cell activation (GO:0033004)	2.48085332
88	neuron cell-cell adhesion (GO:0007158)	2.47420040
89	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.47172137
90	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.46984555
91	protein neddylation (GO:0045116)	2.46775355
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.45290838
93	embryonic epithelial tube formation (GO:0001838)	2.45074325
94	regulation of telomere maintenance (GO:0032204)	2.44232579
95	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.44060096
96	DNA demethylation (GO:0080111)	2.42781075
97	reciprocal meiotic recombination (GO:0007131)	2.41994449
98	reciprocal DNA recombination (GO:0035825)	2.41994449
99	eye photoreceptor cell development (GO:0042462)	2.41195405
100	somite rostral/caudal axis specification (GO:0032525)	2.41045176

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.58520942
2	VDR_22108803_ChIP-Seq_LS180_Human	3.19991665
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.18699527
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80181296
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75467522
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73979728
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.66808463
8	FUS_26573619_Chip-Seq_HEK293_Human	2.47544388
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.46243067
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.37593243
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35071153
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.33312369
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33181370
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.31899516
15	EWS_26573619_Chip-Seq_HEK293_Human	2.31012943
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30237949
17	P300_19829295_ChIP-Seq_ESCs_Human	2.26382669
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20513850
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11314295
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02484140
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88683374
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85421938
23	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84043032
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76870352
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.73989943
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70507190
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70275947
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.66373774
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61866536
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61611498
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61194512
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57678113
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57541519
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55695907
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.53523463
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53523463
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53412318
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52578594
39	STAT3_23295773_ChIP-Seq_U87_Human	1.49778016
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47454828
41	AR_25329375_ChIP-Seq_VCAP_Human	1.46833890
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46534873
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46387970
44	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44764378
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.42199619
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41978463
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41840534
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41421657
49	TCF4_23295773_ChIP-Seq_U87_Human	1.40617560
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40413603
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40385635
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40385635
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39604439
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38602845
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38473738
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38170901
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36901617
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33365066
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33346186
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31733076
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31733076
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31321000
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31165689
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30416326
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.29357684
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.28459283
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28310914
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26248543
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.25919860
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25886391
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25662329
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25032386
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24307875
74	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.20153340
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18126322
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18011230
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14889397
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13764986
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13135365
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12772627
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12772627
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12278156
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10808841
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10077436
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09952694
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06503783
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06202673
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05711740
89	AR_21572438_ChIP-Seq_LNCaP_Human	1.04081620
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.01009756
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00897988
92	AR_20517297_ChIP-Seq_VCAP_Human	0.98665255
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97634502
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97596548
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96071387
96	NCOR_22424771_ChIP-Seq_293T_Human	0.95725347
97	JUN_21703547_ChIP-Seq_K562_Human	0.95607676
98	VDR_23849224_ChIP-Seq_CD4+_Human	0.95410511
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95261081
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.94979919

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.53282350
2	MP0006292_abnormal_olfactory_placode	2.94837975
3	MP0002102_abnormal_ear_morphology	2.78915403
4	MP0003195_calcinosis	2.71944328
5	MP0003787_abnormal_imprinting	2.34164099
6	MP0006072_abnormal_retinal_apoptosis	2.26658090
7	MP0003880_abnormal_central_pattern	2.24390479
8	MP0005551_abnormal_eye_electrophysiolog	2.23326047
9	MP0001968_abnormal_touch/_nociception	2.13563271
10	MP0002837_dystrophic_cardiac_calcinosis	2.04878045
11	MP0002736_abnormal_nociception_after	2.03291066
12	MP0000569_abnormal_digit_pigmentation	1.99987176
13	MP0004885_abnormal_endolymph	1.94744868
14	MP0001984_abnormal_olfaction	1.91212656
15	MP0004133_heterotaxia	1.84326456
16	MP0003136_yellow_coat_color	1.80398895
17	MP0004043_abnormal_pH_regulation	1.78775527
18	MP0005253_abnormal_eye_physiology	1.75869647
19	MP0009046_muscle_twitch	1.73566773
20	MP0002938_white_spotting	1.73387682
21	MP0001529_abnormal_vocalization	1.71447197
22	MP0008872_abnormal_physiological_respon	1.67580619
23	MP0009745_abnormal_behavioral_response	1.67522814
24	MP0004142_abnormal_muscle_tone	1.66472526
25	MP0001486_abnormal_startle_reflex	1.65691064
26	MP0000631_abnormal_neuroendocrine_gland	1.64730849
27	MP0002638_abnormal_pupillary_reflex	1.64663264
28	MP0001485_abnormal_pinna_reflex	1.64323646
29	MP0002272_abnormal_nervous_system	1.59433836
30	MP0006276_abnormal_autonomic_nervous	1.55125904
31	MP0003121_genomic_imprinting	1.51135710
32	MP0005645_abnormal_hypothalamus_physiol	1.49935759
33	MP0008058_abnormal_DNA_repair	1.48527000
34	MP0003890_abnormal_embryonic-extraembry	1.43748726
35	MP0005646_abnormal_pituitary_gland	1.42615047
36	MP0002928_abnormal_bile_duct	1.42578972
37	MP0001986_abnormal_taste_sensitivity	1.41317291
38	MP0005084_abnormal_gallbladder_morpholo	1.39615584
39	MP0003122_maternal_imprinting	1.38829231
40	MP0010386_abnormal_urinary_bladder	1.38273244
41	MP0003718_maternal_effect	1.38255263
42	MP0008995_early_reproductive_senescence	1.36614583
43	MP0000427_abnormal_hair_cycle	1.32010089
44	MP0000778_abnormal_nervous_system	1.28839036
45	MP0008789_abnormal_olfactory_epithelium	1.28067026
46	MP0002653_abnormal_ependyma_morphology	1.28023869
47	MP0002735_abnormal_chemical_nociception	1.26997111
48	MP0002277_abnormal_respiratory_mucosa	1.26383983
49	MP0002138_abnormal_hepatobiliary_system	1.26310785
50	MP0002876_abnormal_thyroid_physiology	1.25125937
51	MP0001293_anophthalmia	1.23597767
52	MP0002163_abnormal_gland_morphology	1.23021826
53	MP0003011_delayed_dark_adaptation	1.22516860
54	MP0004145_abnormal_muscle_electrophysio	1.22268341
55	MP0001501_abnormal_sleep_pattern	1.20943401
56	MP0002572_abnormal_emotion/affect_behav	1.20826934
57	MP0002557_abnormal_social/conspecific_i	1.20750825
58	MP0002751_abnormal_autonomic_nervous	1.19101431
59	MP0000372_irregular_coat_pigmentation	1.18318315
60	MP0004147_increased_porphyrin_level	1.18286803
61	MP0002234_abnormal_pharynx_morphology	1.17341944
62	MP0004742_abnormal_vestibular_system	1.15055345
63	MP0003119_abnormal_digestive_system	1.14020160
64	MP0005386_behavior/neurological_phenoty	1.13314218
65	MP0004924_abnormal_behavior	1.13314218
66	MP0000383_abnormal_hair_follicle	1.09571944
67	MP0000647_abnormal_sebaceous_gland	1.09361390
68	MP0002067_abnormal_sensory_capabilities	1.07670284
69	MP0003937_abnormal_limbs/digits/tail_de	1.07077558
70	MP0003635_abnormal_synaptic_transmissio	1.04385117
71	MP0000516_abnormal_urinary_system	1.01867783
72	MP0005367_renal/urinary_system_phenotyp	1.01867783
73	MP0003252_abnormal_bile_duct	1.01834948
74	MP0005174_abnormal_tail_pigmentation	1.01683222
75	MP0005379_endocrine/exocrine_gland_phen	1.01112458
76	MP0002160_abnormal_reproductive_system	1.01056436
77	MP0005195_abnormal_posterior_eye	1.00935746
78	MP0002734_abnormal_mechanical_nocicepti	1.00705461
79	MP0000566_synostosis	0.99349607
80	MP0003938_abnormal_ear_development	0.99014702
81	MP0000049_abnormal_middle_ear	0.98322341
82	MP0003283_abnormal_digestive_organ	0.98083841
83	MP0002064_seizures	0.97329379
84	MP0005389_reproductive_system_phenotype	0.97282259
85	MP0003646_muscle_fatigue	0.96736922
86	MP0005394_taste/olfaction_phenotype	0.94865808
87	MP0005499_abnormal_olfactory_system	0.94865808
88	MP0001970_abnormal_pain_threshold	0.94055301
89	MP0004215_abnormal_myocardial_fiber	0.93665600
90	MP0002733_abnormal_thermal_nociception	0.93427615
91	MP0002752_abnormal_somatic_nervous	0.92631911
92	MP0003567_abnormal_fetal_cardiomyocyte	0.92342213
93	MP0002063_abnormal_learning/memory/cond	0.91973476
94	MP0001188_hyperpigmentation	0.90243715
95	MP0008875_abnormal_xenobiotic_pharmacok	0.90193064
96	MP0000026_abnormal_inner_ear	0.89708390
97	MP0002233_abnormal_nose_morphology	0.87716012
98	MP0003698_abnormal_male_reproductive	0.83039306
99	MP0005187_abnormal_penis_morphology	0.81545430
100	MP0001919_abnormal_reproductive_system	0.80838860

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32610938
2	Pancreatic fibrosis (HP:0100732)	4.07360259
3	Abnormality of midbrain morphology (HP:0002418)	3.94183789
4	Molar tooth sign on MRI (HP:0002419)	3.94183789
5	True hermaphroditism (HP:0010459)	3.84951220
6	Nephronophthisis (HP:0000090)	3.53255036
7	Abnormality of the renal cortex (HP:0011035)	3.36549395
8	Medial flaring of the eyebrow (HP:0010747)	3.26170008
9	Abnormality of the renal medulla (HP:0100957)	3.19918668
10	Congenital stationary night blindness (HP:0007642)	2.94180173
11	Chronic hepatic failure (HP:0100626)	2.83648261
12	Abnormality of the labia minora (HP:0012880)	2.76238914
13	Cystic liver disease (HP:0006706)	2.69434742
14	Gait imbalance (HP:0002141)	2.65811600
15	Tubular atrophy (HP:0000092)	2.64970143
16	Type II lissencephaly (HP:0007260)	2.61921523
17	Renal cortical cysts (HP:0000803)	2.59183974
18	Congenital primary aphakia (HP:0007707)	2.56876537
19	Colon cancer (HP:0003003)	2.56568826
20	Abolished electroretinogram (ERG) (HP:0000550)	2.54268454
21	Acute necrotizing encephalopathy (HP:0006965)	2.54208819
22	Abnormal biliary tract physiology (HP:0012439)	2.52362116
23	Bile duct proliferation (HP:0001408)	2.52362116
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.49759877
25	Genital tract atresia (HP:0001827)	2.48253664
26	Intestinal atresia (HP:0011100)	2.45409171
27	Progressive macrocephaly (HP:0004481)	2.41588329
28	Vaginal atresia (HP:0000148)	2.41394906
29	Nephrogenic diabetes insipidus (HP:0009806)	2.40576740
30	Optic nerve hypoplasia (HP:0000609)	2.37821536
31	Hyperventilation (HP:0002883)	2.37220613
32	Polydipsia (HP:0001959)	2.35416782
33	Abnormal drinking behavior (HP:0030082)	2.35416782
34	Sclerocornea (HP:0000647)	2.29092602
35	Attenuation of retinal blood vessels (HP:0007843)	2.26973235
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.26455584
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24742253
38	Stomach cancer (HP:0012126)	2.24140980
39	Inability to walk (HP:0002540)	2.22887033
40	Acute encephalopathy (HP:0006846)	2.22724064
41	Anencephaly (HP:0002323)	2.21587313
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18953711
43	Hypothermia (HP:0002045)	2.18781243
44	Mitochondrial inheritance (HP:0001427)	2.18595806
45	Pendular nystagmus (HP:0012043)	2.15876378
46	Septo-optic dysplasia (HP:0100842)	2.14882777
47	Gaze-evoked nystagmus (HP:0000640)	2.11706689
48	Febrile seizures (HP:0002373)	2.10972778
49	Keratoconus (HP:0000563)	2.09792248
50	Increased corneal curvature (HP:0100692)	2.09792248
51	Increased CSF lactate (HP:0002490)	2.04904772
52	Congenital hepatic fibrosis (HP:0002612)	2.04742700
53	Methylmalonic acidemia (HP:0002912)	2.04018635
54	Progressive cerebellar ataxia (HP:0002073)	2.03873896
55	Focal motor seizures (HP:0011153)	2.02987317
56	Lissencephaly (HP:0001339)	2.02941525
57	Broad-based gait (HP:0002136)	2.00531669
58	Postaxial foot polydactyly (HP:0001830)	2.00294192
59	Hyperglycinemia (HP:0002154)	1.98873949
60	Furrowed tongue (HP:0000221)	1.98678095
61	3-Methylglutaconic aciduria (HP:0003535)	1.98382971
62	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97796467
63	Polyuria (HP:0000103)	1.97395115
64	Progressive inability to walk (HP:0002505)	1.97378745
65	Postaxial hand polydactyly (HP:0001162)	1.97019696
66	Male pseudohermaphroditism (HP:0000037)	1.94594013
67	Decreased central vision (HP:0007663)	1.93361857
68	Hepatocellular necrosis (HP:0001404)	1.91024114
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90491374
70	Supernumerary spleens (HP:0009799)	1.86441701
71	Poor coordination (HP:0002370)	1.86217392
72	Neoplasm of the adrenal cortex (HP:0100641)	1.83919288
73	Congenital, generalized hypertrichosis (HP:0004540)	1.82688274
74	Gastrointestinal atresia (HP:0002589)	1.82354375
75	Occipital encephalocele (HP:0002085)	1.79157050
76	Optic disc pallor (HP:0000543)	1.78990407
77	Limb dystonia (HP:0002451)	1.78682812
78	Abnormality of alanine metabolism (HP:0010916)	1.78595534
79	Hyperalaninemia (HP:0003348)	1.78595534
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78595534
81	Hepatic necrosis (HP:0002605)	1.78023351
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75630899
83	Dialeptic seizures (HP:0011146)	1.75299032
84	Cerebellar dysplasia (HP:0007033)	1.75163846
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75141241
86	Lipid accumulation in hepatocytes (HP:0006561)	1.74071808
87	Focal seizures (HP:0007359)	1.71374001
88	Tubulointerstitial nephritis (HP:0001970)	1.70735521
89	Absent/shortened dynein arms (HP:0200106)	1.69952115
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69952115
91	Large for gestational age (HP:0001520)	1.69013162
92	Tubulointerstitial abnormality (HP:0001969)	1.68656703
93	Hemiparesis (HP:0001269)	1.68613771
94	Hyperglycinuria (HP:0003108)	1.68101507
95	Oligodactyly (hands) (HP:0001180)	1.68038766
96	Pachygyria (HP:0001302)	1.68026583
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.67282847
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.67282847
99	Dandy-Walker malformation (HP:0001305)	1.66917076
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.66669198

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.88708597
2	WNK3	2.99638221
3	MAP4K2	2.83093957
4	BMPR1B	2.77787922
5	NUAK1	2.68791160
6	ZAK	2.37526063
7	ADRBK2	2.36181483
8	CASK	2.35288465
9	PINK1	2.31221437
10	GRK1	2.16435374
11	TNIK	2.12595097
12	MAP3K4	2.09372210
13	ACVR1B	2.07285639
14	TRIM28	1.92063841
15	MAPK13	1.88782485
16	MKNK2	1.74924266
17	FGFR2	1.70478458
18	MST4	1.48468781
19	OXSR1	1.45098056
20	WNK4	1.43122449
21	DYRK2	1.39165565
22	TAOK3	1.35880804
23	PNCK	1.34791393
24	BCR	1.33168248
25	MARK1	1.23937428
26	TLK1	1.23543171
27	VRK1	1.22971037
28	INSRR	1.21517720
29	MAP2K7	1.16397059
30	STK39	1.16181580
31	PLK2	1.15652673
32	MKNK1	1.13321462
33	BRSK2	1.13236258
34	PLK4	1.12205511
35	PAK3	1.03231061
36	PLK3	1.02723933
37	CSNK1G1	1.02245780
38	PRKCE	0.98971038
39	TXK	0.98865217
40	CSNK1G2	0.96222678
41	EPHA4	0.94271431
42	PRKCG	0.92739097
43	DAPK2	0.92435016
44	TGFBR1	0.92114202
45	ERBB3	0.91792981
46	TIE1	0.91423647
47	STK38L	0.91396868
48	NTRK3	0.90897582
49	CDK19	0.90109773
50	AKT3	0.87700277
51	TAF1	0.87494199
52	CCNB1	0.83656276
53	BCKDK	0.82839590
54	ADRBK1	0.82029204
55	CSNK1G3	0.81898435
56	NLK	0.78962494
57	VRK2	0.75955374
58	WEE1	0.75943181
59	PIK3CA	0.71762774
60	PHKG2	0.71533058
61	PHKG1	0.71533058
62	STK3	0.69056281
63	NTRK2	0.67812922
64	STK16	0.66385735
65	CSNK1A1L	0.63397658
66	SRPK1	0.62246502
67	EIF2AK3	0.58216372
68	MAPKAPK5	0.56732786
69	CDK3	0.55448385
70	PKN1	0.54552410
71	PLK1	0.52797798
72	CAMK2A	0.51126593
73	EPHA3	0.50713524
74	PRKCQ	0.50377776
75	OBSCN	0.50112131
76	CDC7	0.49599397
77	SGK2	0.49382263
78	CAMKK2	0.48493333
79	FLT3	0.45955381
80	CSNK1A1	0.45559399
81	DYRK3	0.44991174
82	NEK2	0.44261509
83	PASK	0.42669314
84	CSNK1D	0.40634072
85	PRKACA	0.40378723
86	MUSK	0.39581689
87	NME1	0.39549747
88	BUB1	0.39228816
89	ATM	0.39187754
90	TEC	0.38737052
91	PTK2B	0.38643643
92	PRKG1	0.38490793
93	SGK494	0.37118966
94	SGK223	0.37118966
95	RPS6KA5	0.36834795
96	TSSK6	0.34210332
97	CAMK1	0.34197458
98	MINK1	0.33389094
99	ATR	0.33176866
100	LATS1	0.33053016

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.96040330
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63148365
3	Protein export_Homo sapiens_hsa03060	2.59789737
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52581424
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30997140
6	Butanoate metabolism_Homo sapiens_hsa00650	2.19033771
7	Nicotine addiction_Homo sapiens_hsa05033	2.16861043
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.09945489
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07376693
10	Parkinsons disease_Homo sapiens_hsa05012	2.05190561
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.00732588
12	Homologous recombination_Homo sapiens_hsa03440	2.00677323
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.97636075
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.92261490
15	Basal transcription factors_Homo sapiens_hsa03022	1.91381664
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88694085
17	Propanoate metabolism_Homo sapiens_hsa00640	1.85023267
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79333460
19	RNA polymerase_Homo sapiens_hsa03020	1.77651425
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76536784
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74031974
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72886143
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72220829
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67718636
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.64445993
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.61129650
27	RNA degradation_Homo sapiens_hsa03018	1.51760350
28	Taste transduction_Homo sapiens_hsa04742	1.51254482
29	Caffeine metabolism_Homo sapiens_hsa00232	1.48411420
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.44542974
31	Huntingtons disease_Homo sapiens_hsa05016	1.34210897
32	Olfactory transduction_Homo sapiens_hsa04740	1.25178148
33	Alzheimers disease_Homo sapiens_hsa05010	1.22654137
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21822877
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21073638
36	Peroxisome_Homo sapiens_hsa04146	1.18154864
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14563890
38	Morphine addiction_Homo sapiens_hsa05032	1.13678011
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10743455
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.09200863
41	GABAergic synapse_Homo sapiens_hsa04727	1.06219740
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.03698725
43	Retinol metabolism_Homo sapiens_hsa00830	1.03691975
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03142485
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02970480
46	Steroid biosynthesis_Homo sapiens_hsa00100	1.02488566
47	Glutamatergic synapse_Homo sapiens_hsa04724	1.01079658
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96469257
49	Regulation of autophagy_Homo sapiens_hsa04140	0.95535398
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94237703
51	Insulin secretion_Homo sapiens_hsa04911	0.93892094
52	Serotonergic synapse_Homo sapiens_hsa04726	0.91699224
53	Circadian entrainment_Homo sapiens_hsa04713	0.89405241
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89017711
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86967856
56	Mismatch repair_Homo sapiens_hsa03430	0.85672526
57	Proteasome_Homo sapiens_hsa03050	0.85227218
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83598984
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83080343
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82938513
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82360638
62	Purine metabolism_Homo sapiens_hsa00230	0.79541074
63	Circadian rhythm_Homo sapiens_hsa04710	0.77786196
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77775389
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77314211
66	ABC transporters_Homo sapiens_hsa02010	0.70163783
67	One carbon pool by folate_Homo sapiens_hsa00670	0.68173557
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66951927
69	Salivary secretion_Homo sapiens_hsa04970	0.65581625
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.64416056
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.64397938
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63098397
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61623866
74	Metabolic pathways_Homo sapiens_hsa01100	0.61541558
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61063267
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60821017
77	Cocaine addiction_Homo sapiens_hsa05030	0.59554102
78	Fatty acid elongation_Homo sapiens_hsa00062	0.58796753
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.57684617
80	Amphetamine addiction_Homo sapiens_hsa05031	0.56469862
81	RNA transport_Homo sapiens_hsa03013	0.54482772
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.52707799
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49140092
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.48172693
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47693134
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.47527803
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.47262205
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47218763
89	Long-term depression_Homo sapiens_hsa04730	0.45221452
90	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43251897
91	Histidine metabolism_Homo sapiens_hsa00340	0.40818094
92	Fatty acid degradation_Homo sapiens_hsa00071	0.38063228
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37866249
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37503387
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37377941
96	Ribosome_Homo sapiens_hsa03010	0.36236283
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34235798
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33962044
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33908862
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31987147

ZNF626

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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