ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.99953426
2	response to pheromone (GO:0019236)	5.37419033
3	nucleobase catabolic process (GO:0046113)	4.81336847
4	gamma-aminobutyric acid transport (GO:0015812)	3.95298411
5	intraciliary transport (GO:0042073)	3.84380845
6	behavioral response to nicotine (GO:0035095)	3.67384445
7	neural tube formation (GO:0001841)	3.58851531
8	epithelial cilium movement (GO:0003351)	3.55681931
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.51337364
10	presynaptic membrane assembly (GO:0097105)	3.48180494
11	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.46726546
12	regulation of meiosis I (GO:0060631)	3.34322052
13	establishment of mitochondrion localization (GO:0051654)	3.32067986
14	positive regulation of mitochondrial fission (GO:0090141)	3.27722483
15	neuron cell-cell adhesion (GO:0007158)	3.20204826
16	ribonucleoprotein complex disassembly (GO:0032988)	3.18813631
17	protein polyglutamylation (GO:0018095)	3.15494071
18	protein localization to cilium (GO:0061512)	3.10318283
19	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.07946320
20	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.06970392
21	cilium movement (GO:0003341)	3.05770838
22	nonmotile primary cilium assembly (GO:0035058)	3.05007964
23	ubiquinone metabolic process (GO:0006743)	3.04609400
24	DNA integration (GO:0015074)	3.03017907
25	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.01975104
26	organelle disassembly (GO:1903008)	3.00148493
27	presynaptic membrane organization (GO:0097090)	2.99721091
28	regulation of cilium movement (GO:0003352)	2.94612458
29	cilium morphogenesis (GO:0060271)	2.93350306
30	DNA double-strand break processing (GO:0000729)	2.92449844
31	postsynaptic membrane organization (GO:0001941)	2.89558077
32	DNA methylation involved in gamete generation (GO:0043046)	2.86797352
33	platelet dense granule organization (GO:0060155)	2.86501966
34	retinal ganglion cell axon guidance (GO:0031290)	2.86029607
35	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.84305532
36	cilium organization (GO:0044782)	2.83403196
37	protein localization to synapse (GO:0035418)	2.83318090
38	cilium assembly (GO:0042384)	2.83068271
39	cilium or flagellum-dependent cell motility (GO:0001539)	2.81892439
40	ubiquinone biosynthetic process (GO:0006744)	2.81491331
41	pyrimidine dimer repair (GO:0006290)	2.81053766
42	olfactory bulb development (GO:0021772)	2.80781940
43	piRNA metabolic process (GO:0034587)	2.78626074
44	isoprenoid biosynthetic process (GO:0008299)	2.78473249
45	synapse assembly (GO:0007416)	2.77977933
46	single strand break repair (GO:0000012)	2.71669304
47	regulation of development, heterochronic (GO:0040034)	2.71232570
48	tachykinin receptor signaling pathway (GO:0007217)	2.69647710
49	somite rostral/caudal axis specification (GO:0032525)	2.67551091
50	photoreceptor cell maintenance (GO:0045494)	2.65780391
51	sympathetic nervous system development (GO:0048485)	2.65612369
52	limb bud formation (GO:0060174)	2.65351602
53	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64233748
54	head development (GO:0060322)	2.63493266
55	mechanosensory behavior (GO:0007638)	2.63367285
56	axoneme assembly (GO:0035082)	2.56999092
57	regulation of collateral sprouting (GO:0048670)	2.54050691
58	neuronal action potential propagation (GO:0019227)	2.53418475
59	cornea development in camera-type eye (GO:0061303)	2.52886646
60	cerebral cortex radially oriented cell migration (GO:0021799)	2.51905061
61	reflex (GO:0060004)	2.51320612
62	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.50546522
63	cholesterol biosynthetic process (GO:0006695)	2.50232515
64	auditory behavior (GO:0031223)	2.49848474
65	adaptation of signaling pathway (GO:0023058)	2.48909052
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.48443257
67	dendritic spine morphogenesis (GO:0060997)	2.47920128
68	central nervous system projection neuron axonogenesis (GO:0021952)	2.45676935
69	anterograde synaptic vesicle transport (GO:0048490)	2.45258631
70	behavioral response to ethanol (GO:0048149)	2.45187204
71	detection of light stimulus involved in sensory perception (GO:0050962)	2.44185511
72	detection of light stimulus involved in visual perception (GO:0050908)	2.44185511
73	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.42130292
74	kidney morphogenesis (GO:0060993)	2.41823196
75	C4-dicarboxylate transport (GO:0015740)	2.41769465
76	startle response (GO:0001964)	2.41196053
77	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.38809892
78	reciprocal meiotic recombination (GO:0007131)	2.37690651
79	reciprocal DNA recombination (GO:0035825)	2.37690651
80	axonal fasciculation (GO:0007413)	2.36784952
81	central nervous system neuron axonogenesis (GO:0021955)	2.35607277
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.35237598
83	spinal cord development (GO:0021510)	2.34848811
84	protein-chromophore linkage (GO:0018298)	2.33243542
85	mitochondrion transport along microtubule (GO:0047497)	2.32848246
86	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.32848246
87	retinal cone cell development (GO:0046549)	2.31091283
88	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.29937957
89	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.29937957
90	regulation of telomere maintenance (GO:0032204)	2.29895600
91	hippocampus development (GO:0021766)	2.29535367
92	positive regulation of amino acid transport (GO:0051957)	2.29429466
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.27207228
94	axonemal dynein complex assembly (GO:0070286)	2.27120248
95	sterol biosynthetic process (GO:0016126)	2.26263406
96	neuron recognition (GO:0008038)	2.26259446
97	protein localization to Golgi apparatus (GO:0034067)	2.25390032
98	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.24712937
99	mannosylation (GO:0097502)	2.24663383
100	cullin deneddylation (GO:0010388)	2.24402482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.33075523
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.66622794
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.46574803
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.24860220
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.77202624
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74026020
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50777653
8	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47023991
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39868733
10	FUS_26573619_Chip-Seq_HEK293_Human	2.35764616
11	VDR_22108803_ChIP-Seq_LS180_Human	2.35234905
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35009978
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.34150765
14	EWS_26573619_Chip-Seq_HEK293_Human	2.19447257
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.18175685
16	P300_19829295_ChIP-Seq_ESCs_Human	2.17698643
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09781954
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05606078
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.03096740
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00279707
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.94207587
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85143239
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83747396
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79638190
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79250431
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76045758
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.72982217
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67801366
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66480077
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65413060
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64777023
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.64234598
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59042235
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58841513
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56391834
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54652890
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.52781012
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52686656
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50800233
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.48646251
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48646251
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.47939383
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.47045143
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46782471
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46054143
46	* STAT3_23295773_ChIP-Seq_U87_Human	1.45176299
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44053750
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43943427
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43917990
50	AR_25329375_ChIP-Seq_VCAP_Human	1.42760169
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40737131
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38964442
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37686184
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36639072
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36475353
56	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.35246535
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34771523
58	TCF4_23295773_ChIP-Seq_U87_Human	1.28863970
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28478578
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.28263261
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.26888978
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24094909
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20621669
64	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.20220196
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19900319
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19890208
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19890208
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19796934
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17792939
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16684652
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.15268011
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14814543
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14087654
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13229081
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13229081
76	* TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12070622
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11942688
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11349792
79	* TCF4_22108803_ChIP-Seq_LS180_Human	1.11201152
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10908878
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08590592
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07519513
83	SOX9_26525672_Chip-Seq_HEART_Mouse	1.06894111
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04499610
85	JUN_21703547_ChIP-Seq_K562_Human	1.03866019
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03834314
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02872359
88	BCAT_22108803_ChIP-Seq_LS180_Human	1.02735347
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99779344
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98410697
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97828546
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97444626
93	NCOR_22424771_ChIP-Seq_293T_Human	0.95857312
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94544547
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94432442
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94431665
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93686644
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92946029
99	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92723348
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92635696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.24154355
2	MP0003136_yellow_coat_color	3.20129927
3	MP0002837_dystrophic_cardiac_calcinosis	3.09461742
4	MP0002653_abnormal_ependyma_morphology	3.06406211
5	MP0003880_abnormal_central_pattern	2.79195951
6	MP0003890_abnormal_embryonic-extraembry	2.78874998
7	MP0000569_abnormal_digit_pigmentation	2.65552834
8	MP0003787_abnormal_imprinting	2.47335601
9	MP0000778_abnormal_nervous_system	2.34343008
10	MP0008877_abnormal_DNA_methylation	2.30998717
11	MP0006072_abnormal_retinal_apoptosis	2.29928683
12	MP0001529_abnormal_vocalization	2.28813444
13	MP0006292_abnormal_olfactory_placode	2.28143937
14	MP0003122_maternal_imprinting	2.11142303
15	MP0001984_abnormal_olfaction	2.07995362
16	MP0006276_abnormal_autonomic_nervous	2.03223466
17	MP0008789_abnormal_olfactory_epithelium	1.93975364
18	MP0005499_abnormal_olfactory_system	1.91595857
19	MP0005394_taste/olfaction_phenotype	1.91595857
20	MP0005253_abnormal_eye_physiology	1.80332523
21	MP0005551_abnormal_eye_electrophysiolog	1.79110665
22	MP0005171_absent_coat_pigmentation	1.73986851
23	MP0002938_white_spotting	1.65792862
24	MP0009046_muscle_twitch	1.64900833
25	MP0004133_heterotaxia	1.63903464
26	MP0003121_genomic_imprinting	1.61737190
27	MP0002736_abnormal_nociception_after	1.57640368
28	MP0002638_abnormal_pupillary_reflex	1.56577507
29	MP0008058_abnormal_DNA_repair	1.52713106
30	MP0001968_abnormal_touch/_nociception	1.51828764
31	MP0009745_abnormal_behavioral_response	1.51601492
32	MP0001486_abnormal_startle_reflex	1.50517766
33	MP0001293_anophthalmia	1.48129934
34	MP0004142_abnormal_muscle_tone	1.42362085
35	MP0003635_abnormal_synaptic_transmissio	1.42280108
36	MP0002272_abnormal_nervous_system	1.42010777
37	MP0002735_abnormal_chemical_nociception	1.37204518
38	MP0000631_abnormal_neuroendocrine_gland	1.35978523
39	MP0002751_abnormal_autonomic_nervous	1.35689277
40	MP0000427_abnormal_hair_cycle	1.32291727
41	MP0002234_abnormal_pharynx_morphology	1.31473649
42	MP0004270_analgesia	1.30194949
43	MP0002557_abnormal_social/conspecific_i	1.29936644
44	MP0002572_abnormal_emotion/affect_behav	1.27071413
45	MP0005187_abnormal_penis_morphology	1.26532354
46	MP0004859_abnormal_synaptic_plasticity	1.25506990
47	MP0004147_increased_porphyrin_level	1.25195367
48	MP0002095_abnormal_skin_pigmentation	1.24127142
49	MP0004924_abnormal_behavior	1.23617972
50	MP0005386_behavior/neurological_phenoty	1.23617972
51	MP0002160_abnormal_reproductive_system	1.23495408
52	MP0005248_abnormal_Harderian_gland	1.20275103
53	MP0002063_abnormal_learning/memory/cond	1.18745697
54	MP0005645_abnormal_hypothalamus_physiol	1.16577943
55	MP0002752_abnormal_somatic_nervous	1.15014221
56	MP0003195_calcinosis	1.14739745
57	MP0000955_abnormal_spinal_cord	1.14113835
58	MP0000049_abnormal_middle_ear	1.13259464
59	MP0002184_abnormal_innervation	1.13018265
60	MP0001324_abnormal_eye_pigmentation	1.12649730
61	MP0003937_abnormal_limbs/digits/tail_de	1.12334540
62	MP0002067_abnormal_sensory_capabilities	1.11535955
63	MP0005391_vision/eye_phenotype	1.11049408
64	MP0002928_abnormal_bile_duct	1.10937199
65	MP0002882_abnormal_neuron_morphology	1.10773265
66	MP0000647_abnormal_sebaceous_gland	1.10393408
67	MP0002734_abnormal_mechanical_nocicepti	1.09831192
68	MP0002822_catalepsy	1.06337295
69	MP0001986_abnormal_taste_sensitivity	1.05712415
70	MP0005084_abnormal_gallbladder_morpholo	1.04195477
71	MP0002233_abnormal_nose_morphology	1.03788044
72	MP0003119_abnormal_digestive_system	1.03494337
73	MP0005075_abnormal_melanosome_morpholog	1.03425859
74	MP0005195_abnormal_posterior_eye	1.03260681
75	MP0004145_abnormal_muscle_electrophysio	0.99516842
76	MP0008872_abnormal_physiological_respon	0.99391834
77	MP0005423_abnormal_somatic_nervous	0.99163213
78	MP0003646_muscle_fatigue	0.98846119
79	MP0003567_abnormal_fetal_cardiomyocyte	0.98713712
80	MP0004811_abnormal_neuron_physiology	0.97556443
81	MP0002064_seizures	0.96790353
82	MP0001970_abnormal_pain_threshold	0.95768390
83	MP0003861_abnormal_nervous_system	0.95211438
84	MP0001188_hyperpigmentation	0.93982482
85	MP0003011_delayed_dark_adaptation	0.93627283
86	MP0000372_irregular_coat_pigmentation	0.93576716
87	MP0004885_abnormal_endolymph	0.93391091
88	MP0001286_abnormal_eye_development	0.92135428
89	MP0003137_abnormal_impulse_conducting	0.91558133
90	MP0002152_abnormal_brain_morphology	0.89664143
91	MP0002733_abnormal_thermal_nociception	0.89032815
92	MP0004043_abnormal_pH_regulation	0.87475859
93	MP0001485_abnormal_pinna_reflex	0.83194433
94	MP0000026_abnormal_inner_ear	0.79835627
95	MP0004742_abnormal_vestibular_system	0.79153666
96	MP0003221_abnormal_cardiomyocyte_apopto	0.78568318
97	MP0002163_abnormal_gland_morphology	0.77209939
98	MP0003755_abnormal_palate_morphology	0.74879849
99	MP0006035_abnormal_mitochondrial_morpho	0.74411158
100	MP0003698_abnormal_male_reproductive	0.72219880

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.10829802
2	Focal motor seizures (HP:0011153)	3.73754480
3	Colon cancer (HP:0003003)	3.63947874
4	True hermaphroditism (HP:0010459)	3.60877399
5	Pancreatic fibrosis (HP:0100732)	3.58898249
6	Nephrogenic diabetes insipidus (HP:0009806)	3.55365463
7	Medial flaring of the eyebrow (HP:0010747)	3.55289540
8	Gait imbalance (HP:0002141)	3.50360741
9	Congenital primary aphakia (HP:0007707)	3.32084710
10	Lissencephaly (HP:0001339)	3.25206446
11	Pendular nystagmus (HP:0012043)	3.04313849
12	Nephronophthisis (HP:0000090)	3.02422495
13	Genital tract atresia (HP:0001827)	3.02143762
14	Vaginal atresia (HP:0000148)	3.01571392
15	Type II lissencephaly (HP:0007260)	2.89123221
16	Abnormality of the renal medulla (HP:0100957)	2.70838865
17	Molar tooth sign on MRI (HP:0002419)	2.61490732
18	Abnormality of midbrain morphology (HP:0002418)	2.61490732
19	Abnormality of the renal cortex (HP:0011035)	2.59249741
20	Abnormality of the labia minora (HP:0012880)	2.58977238
21	Chronic hepatic failure (HP:0100626)	2.53692564
22	Retinal dysplasia (HP:0007973)	2.51667191
23	Hip dysplasia (HP:0001385)	2.43570572
24	Hyperventilation (HP:0002883)	2.42308947
25	Pachygyria (HP:0001302)	2.41935803
26	Specific learning disability (HP:0001328)	2.40820025
27	Carpal bone hypoplasia (HP:0001498)	2.40022742
28	Cortical dysplasia (HP:0002539)	2.38422192
29	Poor coordination (HP:0002370)	2.36335616
30	Cerebellar dysplasia (HP:0007033)	2.33877334
31	Renal cortical cysts (HP:0000803)	2.31749251
32	Drooling (HP:0002307)	2.31086798
33	Anencephaly (HP:0002323)	2.29986280
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29404347
35	Cystic liver disease (HP:0006706)	2.29252378
36	3-Methylglutaconic aciduria (HP:0003535)	2.27333875
37	Progressive inability to walk (HP:0002505)	2.25808687
38	Focal seizures (HP:0007359)	2.25761764
39	Polyphagia (HP:0002591)	2.18171396
40	Occipital encephalocele (HP:0002085)	2.17849544
41	Inability to walk (HP:0002540)	2.17245543
42	Postaxial foot polydactyly (HP:0001830)	2.16766011
43	Hemiparesis (HP:0001269)	2.11796165
44	Intestinal atresia (HP:0011100)	2.11051108
45	Hyperglycinemia (HP:0002154)	2.10390003
46	Glioma (HP:0009733)	2.10234852
47	Postaxial hand polydactyly (HP:0001162)	2.08424097
48	Neoplasm of the adrenal cortex (HP:0100641)	2.08235320
49	Abnormality of macular pigmentation (HP:0008002)	2.07093326
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.05808864
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05808864
52	Excessive salivation (HP:0003781)	2.04400844
53	Optic nerve hypoplasia (HP:0000609)	2.03459148
54	Abnormal ciliary motility (HP:0012262)	2.00498537
55	Abolished electroretinogram (ERG) (HP:0000550)	1.99703240
56	Medulloblastoma (HP:0002885)	1.99198769
57	Abnormality of the astrocytes (HP:0100707)	1.96568223
58	Astrocytoma (HP:0009592)	1.96568223
59	Dialeptic seizures (HP:0011146)	1.96331797
60	Absent speech (HP:0001344)	1.96031325
61	Sclerocornea (HP:0000647)	1.95969355
62	Limb dystonia (HP:0002451)	1.95846579
63	Progressive cerebellar ataxia (HP:0002073)	1.95658295
64	Absent eyebrow (HP:0002223)	1.95149646
65	Congenital hepatic fibrosis (HP:0002612)	1.93041579
66	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.92046791
67	Broad foot (HP:0001769)	1.91195484
68	Anophthalmia (HP:0000528)	1.90838281
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89698243
70	Decreased testicular size (HP:0008734)	1.89100000
71	Tubulointerstitial nephritis (HP:0001970)	1.88858667
72	Retinitis pigmentosa (HP:0000510)	1.88292350
73	Methylmalonic acidemia (HP:0002912)	1.87716158
74	Broad-based gait (HP:0002136)	1.86399569
75	Hypoplasia of the brainstem (HP:0002365)	1.85795154
76	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.85795154
77	Short foot (HP:0001773)	1.85415233
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82717247
79	Hepatoblastoma (HP:0002884)	1.82448520
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80129008
81	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.79075767
82	Polymicrogyria (HP:0002126)	1.78237315
83	Astigmatism (HP:0000483)	1.77248449
84	Narrow forehead (HP:0000341)	1.76972692
85	Tubulointerstitial abnormality (HP:0001969)	1.73844137
86	Methylmalonic aciduria (HP:0012120)	1.73800835
87	Dandy-Walker malformation (HP:0001305)	1.70756239
88	Multicystic kidney dysplasia (HP:0000003)	1.70152551
89	Supernumerary spleens (HP:0009799)	1.69924306
90	Tubular atrophy (HP:0000092)	1.69854397
91	Ependymoma (HP:0002888)	1.68394964
92	Short tibia (HP:0005736)	1.67378220
93	Congenital stationary night blindness (HP:0007642)	1.66824934
94	Oligodactyly (hands) (HP:0001180)	1.66762662
95	Abnormal biliary tract physiology (HP:0012439)	1.66640910
96	Bile duct proliferation (HP:0001408)	1.66640910
97	Thyroiditis (HP:0100646)	1.66441616
98	Failure to thrive in infancy (HP:0001531)	1.66219835
99	Preaxial hand polydactyly (HP:0001177)	1.63699707
100	Aplasia/Hypoplasia of the lens (HP:0008063)	1.62239588

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.53699955
2	LATS1	3.26581826
3	MAP3K4	3.13639526
4	BCR	3.02133015
5	CASK	2.96060706
6	FRK	2.88761468
7	STK38L	2.85903428
8	WNK3	2.84180426
9	MAP4K2	2.59440422
10	MAP2K7	2.57519245
11	BMPR1B	2.53783330
12	SRPK1	2.49157654
13	TRIM28	2.25639037
14	ZAK	2.22405980
15	NUAK1	1.99121949
16	DYRK2	1.99067514
17	MAPK13	1.85037621
18	CSNK1A1L	1.82769416
19	CSNK1G3	1.73024063
20	CSNK1G2	1.72886598
21	DYRK3	1.64403592
22	CSNK1G1	1.62829352
23	PINK1	1.50578209
24	ERBB3	1.39269747
25	ACVR1B	1.35284498
26	EPHA3	1.31536713
27	CDK19	1.26398040
28	MAP2K4	1.25897472
29	ADRBK2	1.23227518
30	GRK1	1.21111949
31	MKNK2	1.16629552
32	INSRR	1.15945318
33	EPHA4	1.14401119
34	TNIK	1.11001596
35	CAMKK2	1.04390418
36	PAK3	1.00617111
37	EIF2AK3	1.00363947
38	PNCK	0.99675975
39	NTRK3	0.98143491
40	MKNK1	0.96393381
41	RPS6KA4	0.91961197
42	MINK1	0.90838118
43	PLK2	0.88824777
44	FER	0.85506874
45	STK38	0.85165307
46	BCKDK	0.84794749
47	DYRK1A	0.81163473
48	STK16	0.80972957
49	TGFBR1	0.78258649
50	PRKCE	0.77880903
51	VRK1	0.75521990
52	NEK1	0.71339849
53	PRKCG	0.69932815
54	DYRK1B	0.68581077
55	BRD4	0.68126022
56	PLK3	0.67808181
57	NTRK2	0.67349478
58	WNK4	0.66328091
59	CCNB1	0.63659815
60	NLK	0.62726732
61	FLT3	0.61140535
62	TAOK3	0.59816136
63	STK3	0.59029517
64	OXSR1	0.57980857
65	PLK1	0.50559396
66	PLK4	0.49438337
67	RPS6KA5	0.49035386
68	SIK3	0.47421268
69	CDK5	0.47257632
70	STK39	0.46116937
71	LATS2	0.45369511
72	CDK3	0.45086716
73	MAP3K6	0.45078373
74	PIM2	0.44893547
75	EPHB2	0.44466518
76	FGFR2	0.43162310
77	CAMK2A	0.43064839
78	CAMK4	0.42766643
79	BRSK2	0.42273699
80	PHKG2	0.42128430
81	PHKG1	0.42128430
82	MAP3K5	0.41892224
83	CSNK1D	0.41788448
84	CSNK1A1	0.40400141
85	ADRBK1	0.39390949
86	TSSK6	0.39091200
87	PKN1	0.38934069
88	NEK2	0.38715234
89	ATM	0.37668024
90	UHMK1	0.35431647
91	TIE1	0.35003626
92	YES1	0.34795962
93	PRKACB	0.33863465
94	PRKACA	0.30581618
95	ATR	0.27914364
96	PRKAA1	0.26439229
97	AKT3	0.25484659
98	STK11	0.24747090
99	CSNK1E	0.24568556
100	PRKCZ	0.24478908

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.01169908
2	Nicotine addiction_Homo sapiens_hsa05033	2.92883245
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.85014224
4	Phototransduction_Homo sapiens_hsa04744	2.83489248
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.72970534
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.57359295
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.47564054
8	Protein export_Homo sapiens_hsa03060	2.28318718
9	Butanoate metabolism_Homo sapiens_hsa00650	2.24412846
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23975960
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.16586185
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.93555009
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78642766
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75541548
15	Basal transcription factors_Homo sapiens_hsa03022	1.75345941
16	Propanoate metabolism_Homo sapiens_hsa00640	1.73879733
17	GABAergic synapse_Homo sapiens_hsa04727	1.66453050
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.66430072
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66345957
20	Taste transduction_Homo sapiens_hsa04742	1.57679147
21	RNA degradation_Homo sapiens_hsa03018	1.54109529
22	Parkinsons disease_Homo sapiens_hsa05012	1.44856922
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.43988214
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43196083
25	Morphine addiction_Homo sapiens_hsa05032	1.40050938
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.37010704
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.32568434
28	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.29347212
29	Peroxisome_Homo sapiens_hsa04146	1.27432075
30	RNA polymerase_Homo sapiens_hsa03020	1.24046534
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22647182
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21480140
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.16035592
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14612090
35	Fatty acid elongation_Homo sapiens_hsa00062	1.12042997
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.09898065
37	Homologous recombination_Homo sapiens_hsa03440	1.09299850
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08406201
39	Huntingtons disease_Homo sapiens_hsa05016	1.07630311
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05617706
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.04411811
42	Axon guidance_Homo sapiens_hsa04360	1.00134379
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99199725
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.96522098
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95856961
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95506153
47	Circadian entrainment_Homo sapiens_hsa04713	0.94591065
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94581867
49	Cocaine addiction_Homo sapiens_hsa05030	0.92384915
50	Caffeine metabolism_Homo sapiens_hsa00232	0.92281497
51	Regulation of autophagy_Homo sapiens_hsa04140	0.88699356
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87011932
53	Olfactory transduction_Homo sapiens_hsa04740	0.86213439
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84569338
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.84200655
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82529154
57	Serotonergic synapse_Homo sapiens_hsa04726	0.82342428
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82297166
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.80071934
60	Circadian rhythm_Homo sapiens_hsa04710	0.79681897
61	Basal cell carcinoma_Homo sapiens_hsa05217	0.79430901
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78879809
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78570298
64	RNA transport_Homo sapiens_hsa03013	0.76675007
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74143603
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73375470
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70325432
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.69548253
69	Alcoholism_Homo sapiens_hsa05034	0.67262406
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62699877
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61325673
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61262335
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60877995
74	Metabolic pathways_Homo sapiens_hsa01100	0.60852348
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59355082
76	Alzheimers disease_Homo sapiens_hsa05010	0.57058833
77	Oocyte meiosis_Homo sapiens_hsa04114	0.56533220
78	Mismatch repair_Homo sapiens_hsa03430	0.56145368
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56028592
80	Retinol metabolism_Homo sapiens_hsa00830	0.55951147
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.54407809
82	ABC transporters_Homo sapiens_hsa02010	0.52544151
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52104393
84	Base excision repair_Homo sapiens_hsa03410	0.50314205
85	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49033794
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47636832
87	Purine metabolism_Homo sapiens_hsa00230	0.47104119
88	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46786888
89	Insulin secretion_Homo sapiens_hsa04911	0.46011340
90	Long-term depression_Homo sapiens_hsa04730	0.45443217
91	Spliceosome_Homo sapiens_hsa03040	0.45322147
92	Fatty acid degradation_Homo sapiens_hsa00071	0.44893435
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43516033
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41508160
95	Amphetamine addiction_Homo sapiens_hsa05031	0.39923828
96	Gap junction_Homo sapiens_hsa04540	0.39601622
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39242954
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38499108
99	Sulfur relay system_Homo sapiens_hsa04122	0.38364905
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38318864

ZNF627

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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