ZNF638

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline transport (GO:0015824)4.63034325
2presynaptic membrane assembly (GO:0097105)4.36525329
3synaptic vesicle maturation (GO:0016188)4.26998217
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03772402
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97486718
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.91629736
7presynaptic membrane organization (GO:0097090)3.81430644
8C4-dicarboxylate transport (GO:0015740)3.46284298
9cellular potassium ion homeostasis (GO:0030007)3.45435316
10nuclear pore complex assembly (GO:0051292)3.45344963
11cerebellar Purkinje cell differentiation (GO:0021702)3.30128712
12nuclear pore organization (GO:0006999)3.26797147
13prenylation (GO:0097354)3.22499802
14protein prenylation (GO:0018342)3.22499802
15establishment of nucleus localization (GO:0040023)3.18873439
16monoubiquitinated protein deubiquitination (GO:0035520)3.18522133
17central nervous system projection neuron axonogenesis (GO:0021952)3.12269680
18regulation of cardiac muscle cell contraction (GO:0086004)3.06040467
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.02111392
20mitotic sister chromatid cohesion (GO:0007064)3.01466726
21neuron cell-cell adhesion (GO:0007158)2.98777211
22axonal fasciculation (GO:0007413)2.98120997
23replicative senescence (GO:0090399)2.96037568
24negative regulation of translation, ncRNA-mediated (GO:0040033)2.95097481
25regulation of translation, ncRNA-mediated (GO:0045974)2.95097481
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95097481
27gamma-aminobutyric acid signaling pathway (GO:0007214)2.87521915
28regulation of synaptic vesicle exocytosis (GO:2000300)2.87491585
29neuronal action potential propagation (GO:0019227)2.86863008
30neurotransmitter-gated ion channel clustering (GO:0072578)2.86349634
31protein localization to synapse (GO:0035418)2.86153570
32central nervous system neuron axonogenesis (GO:0021955)2.85861178
33neural tube formation (GO:0001841)2.85794031
34nucleus localization (GO:0051647)2.82610202
35DNA integration (GO:0015074)2.81973991
36DNA replication-dependent nucleosome assembly (GO:0006335)2.81234958
37DNA replication-dependent nucleosome organization (GO:0034723)2.81234958
38establishment of protein localization to Golgi (GO:0072600)2.81036574
39regulation of centrosome duplication (GO:0010824)2.79646242
40regulation of centriole replication (GO:0046599)2.79165317
41dendrite morphogenesis (GO:0048813)2.77592360
42negative regulation of neurotransmitter secretion (GO:0046929)2.77355657
43microtubule anchoring (GO:0034453)2.77006786
44detection of calcium ion (GO:0005513)2.71499424
45glutamate secretion (GO:0014047)2.71420792
46dorsal/ventral axis specification (GO:0009950)2.70425194
47regulation of DNA endoreduplication (GO:0032875)2.69537097
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68091836
49neuron recognition (GO:0008038)2.68023946
50microtubule depolymerization (GO:0007019)2.67234041
51regulation of centrosome cycle (GO:0046605)2.63814389
52interkinetic nuclear migration (GO:0022027)2.58462330
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57808136
54L-amino acid import (GO:0043092)2.57183638
55negative regulation of neurotransmitter transport (GO:0051589)2.55891597
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54503491
57centrosome duplication (GO:0051298)2.52580599
58pyrimidine nucleobase catabolic process (GO:0006208)2.51339250
59replication fork processing (GO:0031297)2.50286162
60lipid translocation (GO:0034204)2.49984959
61phospholipid translocation (GO:0045332)2.49984959
62cellular sodium ion homeostasis (GO:0006883)2.49497184
63synaptic vesicle exocytosis (GO:0016079)2.49018927
64glutamate receptor signaling pathway (GO:0007215)2.48865671
65membrane depolarization during action potential (GO:0086010)2.48724162
66alanine transport (GO:0032328)2.47460630
67cytoplasmic mRNA processing body assembly (GO:0033962)2.46345128
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45498693
69gamma-aminobutyric acid transport (GO:0015812)2.44708985
70positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43362820
71regulation of synaptic vesicle transport (GO:1902803)2.41652344
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40357505
73regulation of somitogenesis (GO:0014807)2.39454879
74vocalization behavior (GO:0071625)2.39074218
75regulation of neurotransmitter secretion (GO:0046928)2.37944673
76protein targeting to Golgi (GO:0000042)2.37784578
77regulation of sarcomere organization (GO:0060297)2.37456781
78postsynaptic membrane organization (GO:0001941)2.37318886
79negative regulation of DNA recombination (GO:0045910)2.36764057
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36598332
81pore complex assembly (GO:0046931)2.36101954
82synaptic transmission, glutamatergic (GO:0035249)2.36008303
83regulation of actin filament-based movement (GO:1903115)2.35296726
84resolution of meiotic recombination intermediates (GO:0000712)2.35123616
85somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34659473
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.34659473
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34192736
88protein K48-linked deubiquitination (GO:0071108)2.33515308
89chemosensory behavior (GO:0007635)2.32875030
90otic vesicle formation (GO:0030916)2.32786923
91regulation of establishment of cell polarity (GO:2000114)2.32190349
92neuron-neuron synaptic transmission (GO:0007270)2.31129480
93neurotransmitter uptake (GO:0001504)2.30790255
94mechanosensory behavior (GO:0007638)2.29917717
95olfactory bulb development (GO:0021772)2.29500379
96pre-miRNA processing (GO:0031054)2.29496359
97negative regulation of dendrite development (GO:2000171)2.27787778
98sodium ion export (GO:0071436)2.27542285
99intraciliary transport (GO:0042073)2.26599959
100regulation of pigment cell differentiation (GO:0050932)2.24679063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.94364190
2GBX2_23144817_ChIP-Seq_PC3_Human3.37128443
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.15984533
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04751712
5TAF15_26573619_Chip-Seq_HEK293_Human3.04653841
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95747268
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83773661
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81745325
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80664784
10FUS_26573619_Chip-Seq_HEK293_Human2.64049987
11IGF1R_20145208_ChIP-Seq_DFB_Human2.50749997
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49212130
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39543718
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18474511
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18159617
16EZH2_22144423_ChIP-Seq_EOC_Human2.17260993
17EWS_26573619_Chip-Seq_HEK293_Human2.11428899
18P300_19829295_ChIP-Seq_ESCs_Human2.11292442
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03098867
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00954524
21* SMAD4_21799915_ChIP-Seq_A2780_Human1.93452359
22MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.88097540
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84050031
24STAT3_23295773_ChIP-Seq_U87_Human1.84038391
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82741376
26ZNF274_21170338_ChIP-Seq_K562_Hela1.79604541
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76604698
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.76327524
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.73550058
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71049607
31AR_21572438_ChIP-Seq_LNCaP_Human1.70060676
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59679479
33TP53_16413492_ChIP-PET_HCT116_Human1.58586704
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56506793
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56418538
36TCF4_23295773_ChIP-Seq_U87_Human1.55056969
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54487686
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.52840506
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52812142
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51756470
41ER_23166858_ChIP-Seq_MCF-7_Human1.48889825
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44737759
43CBP_20019798_ChIP-Seq_JUKART_Human1.44425873
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44425873
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41926485
46AR_25329375_ChIP-Seq_VCAP_Human1.40671739
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37866001
48IRF1_19129219_ChIP-ChIP_H3396_Human1.37739280
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37049679
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.35784124
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35382830
52SOX9_26525672_Chip-Seq_HEART_Mouse1.31683722
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30866240
54VDR_22108803_ChIP-Seq_LS180_Human1.30527411
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30481783
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30372319
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30316857
58RNF2_27304074_Chip-Seq_NSC_Mouse1.30149890
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29912137
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29435627
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.28542035
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28072801
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28072801
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27641061
65AHR_22903824_ChIP-Seq_MCF-7_Human1.25906350
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.25535809
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24384600
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.24344441
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23917791
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22165381
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20364760
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20347314
73RUNX2_22187159_ChIP-Seq_PCA_Human1.19332107
74* SMAD_19615063_ChIP-ChIP_OVARY_Human1.18807276
75BCAT_22108803_ChIP-Seq_LS180_Human1.16676649
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16586632
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16137958
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15143461
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14110833
80KDM2B_26808549_Chip-Seq_REH_Human1.14108594
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.12673987
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.10802462
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09629214
84TP53_18474530_ChIP-ChIP_U2OS_Human1.09144525
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09142972
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08605423
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08414720
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07905312
89JUN_21703547_ChIP-Seq_K562_Human1.06971027
90* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06298807
91P53_22387025_ChIP-Seq_ESCs_Mouse1.04907638
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03952195
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03843293
94TCF4_22108803_ChIP-Seq_LS180_Human1.03319448
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.03242925
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03094635
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02898235
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02898235
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02654062
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02605282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.15614726
2MP0008057_abnormal_DNA_replication3.75833140
3MP0003880_abnormal_central_pattern3.29114729
4MP0004270_analgesia2.87685611
5MP0004859_abnormal_synaptic_plasticity2.68226313
6MP0005423_abnormal_somatic_nervous2.41992444
7MP0003890_abnormal_embryonic-extraembry2.37836593
8MP0009046_muscle_twitch2.34641408
9MP0008877_abnormal_DNA_methylation2.27649388
10MP0002735_abnormal_chemical_nociception2.15665235
11MP0000778_abnormal_nervous_system2.13930039
12MP0003635_abnormal_synaptic_transmissio2.09794544
13MP0003787_abnormal_imprinting2.00730020
14MP0001486_abnormal_startle_reflex1.93495401
15MP0009745_abnormal_behavioral_response1.90448834
16MP0002064_seizures1.86288957
17MP0002272_abnormal_nervous_system1.81527581
18MP0001984_abnormal_olfaction1.74194118
19MP0002063_abnormal_learning/memory/cond1.68019877
20MP0006292_abnormal_olfactory_placode1.66572361
21MP0002734_abnormal_mechanical_nocicepti1.63377867
22MP0003121_genomic_imprinting1.60317642
23MP0001968_abnormal_touch/_nociception1.54729455
24MP0002736_abnormal_nociception_after1.52652894
25MP0005187_abnormal_penis_morphology1.52371579
26MP0002009_preneoplasia1.51492076
27MP0001177_atelectasis1.47652620
28MP0002067_abnormal_sensory_capabilities1.46964307
29MP0003122_maternal_imprinting1.44958908
30MP0004147_increased_porphyrin_level1.44314364
31MP0003937_abnormal_limbs/digits/tail_de1.42357041
32MP0005386_behavior/neurological_phenoty1.39528846
33MP0004924_abnormal_behavior1.39528846
34MP0010094_abnormal_chromosome_stability1.38510897
35MP0000955_abnormal_spinal_cord1.38020174
36MP0002572_abnormal_emotion/affect_behav1.33409232
37MP0004811_abnormal_neuron_physiology1.31586081
38MP0002184_abnormal_innervation1.31407377
39MP0003221_abnormal_cardiomyocyte_apopto1.27496952
40MP0000383_abnormal_hair_follicle1.25272586
41MP0005253_abnormal_eye_physiology1.24121153
42MP0001299_abnormal_eye_distance/1.21693065
43MP0006276_abnormal_autonomic_nervous1.21072921
44MP0009697_abnormal_copulation1.18126481
45MP0002152_abnormal_brain_morphology1.17275273
46MP0002557_abnormal_social/conspecific_i1.17220582
47MP0002102_abnormal_ear_morphology1.15562016
48MP0000631_abnormal_neuroendocrine_gland1.15298698
49MP0002882_abnormal_neuron_morphology1.14215843
50MP0002822_catalepsy1.13860787
51MP0003633_abnormal_nervous_system1.13184518
52MP0005551_abnormal_eye_electrophysiolog1.09835686
53MP0003861_abnormal_nervous_system1.09609780
54MP0001502_abnormal_circadian_rhythm1.09551407
55MP0006072_abnormal_retinal_apoptosis1.08660963
56MP0008058_abnormal_DNA_repair1.06177652
57MP0001529_abnormal_vocalization1.03664104
58MP0003385_abnormal_body_wall1.02542206
59MP0008872_abnormal_physiological_respon1.02030611
60MP0004215_abnormal_myocardial_fiber1.01801057
61MP0003631_nervous_system_phenotype0.99664941
62MP0002233_abnormal_nose_morphology0.98897243
63MP0005645_abnormal_hypothalamus_physiol0.98031944
64MP0005248_abnormal_Harderian_gland0.97947231
65MP0005171_absent_coat_pigmentation0.94899092
66MP0001485_abnormal_pinna_reflex0.93758774
67MP0003632_abnormal_nervous_system0.91772519
68MP0009703_decreased_birth_body0.90663814
69MP0000427_abnormal_hair_cycle0.88932678
70MP0010678_abnormal_skin_adnexa0.88551891
71MP0002638_abnormal_pupillary_reflex0.88512336
72MP0003567_abnormal_fetal_cardiomyocyte0.88249707
73MP0002234_abnormal_pharynx_morphology0.87973341
74MP0002733_abnormal_thermal_nociception0.87772101
75MP0000428_abnormal_craniofacial_morphol0.86767187
76MP0002752_abnormal_somatic_nervous0.86533589
77MP0003935_abnormal_craniofacial_develop0.86532767
78MP0003698_abnormal_male_reproductive0.85572153
79MP0002697_abnormal_eye_size0.85393332
80MP0001293_anophthalmia0.81324892
81MP0002751_abnormal_autonomic_nervous0.80795004
82MP0002081_perinatal_lethality0.79731071
83MP0001929_abnormal_gametogenesis0.79211879
84MP0001440_abnormal_grooming_behavior0.78528247
85MP0001970_abnormal_pain_threshold0.78502476
86MP0002084_abnormal_developmental_patter0.78016024
87MP0002066_abnormal_motor_capabilities/c0.77896113
88MP0002160_abnormal_reproductive_system0.76789886
89MP0004742_abnormal_vestibular_system0.75980735
90MP0001286_abnormal_eye_development0.75815536
91MP0003183_abnormal_peptide_metabolism0.75392685
92MP0005391_vision/eye_phenotype0.75201474
93MP0002938_white_spotting0.74929270
94MP0002082_postnatal_lethality0.73177156
95MP0010770_preweaning_lethality0.73177156
96MP0004085_abnormal_heartbeat0.72646255
97MP0004197_abnormal_fetal_growth/weight/0.72597469
98MP0004142_abnormal_muscle_tone0.71469338
99MP0005646_abnormal_pituitary_gland0.70906456
100MP0003755_abnormal_palate_morphology0.70877317

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.31583134
2Febrile seizures (HP:0002373)3.68589966
3Atonic seizures (HP:0010819)3.68322604
4Drooling (HP:0002307)3.53205220
5Excessive salivation (HP:0003781)3.19758106
6Focal motor seizures (HP:0011153)3.19139455
7Volvulus (HP:0002580)3.17500374
8Cerebellar dysplasia (HP:0007033)2.93849460
9Protruding tongue (HP:0010808)2.88984835
10Hemiplegia (HP:0002301)2.84149663
11Papillary thyroid carcinoma (HP:0002895)2.84083212
12Medulloblastoma (HP:0002885)2.75218637
13Focal seizures (HP:0007359)2.70079143
14Tubulointerstitial nephritis (HP:0001970)2.61026065
15Impaired vibration sensation in the lower limbs (HP:0002166)2.58731536
16Broad-based gait (HP:0002136)2.55070887
17Neoplasm of the oral cavity (HP:0100649)2.54838386
18Progressive cerebellar ataxia (HP:0002073)2.51688564
19Abnormality of chromosome stability (HP:0003220)2.44176329
20Dialeptic seizures (HP:0011146)2.43660993
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43597968
22Short 4th metacarpal (HP:0010044)2.43597968
23Gaze-evoked nystagmus (HP:0000640)2.40726613
24Abnormality of the astrocytes (HP:0100707)2.40520350
25Astrocytoma (HP:0009592)2.40520350
26Intestinal atresia (HP:0011100)2.34797858
27Epileptic encephalopathy (HP:0200134)2.29449548
28Absence seizures (HP:0002121)2.28814681
29Genetic anticipation (HP:0003743)2.27702243
30Pancreatic fibrosis (HP:0100732)2.18378985
31Aqueductal stenosis (HP:0002410)2.17703633
32Abnormality of the corticospinal tract (HP:0002492)2.15104125
33Fair hair (HP:0002286)2.14172027
34Chronic hepatic failure (HP:0100626)2.13351136
35Pancreatic cysts (HP:0001737)2.10591723
36Urinary bladder sphincter dysfunction (HP:0002839)2.09092307
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.07601824
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07601824
39Lissencephaly (HP:0001339)2.07173342
40Hepatoblastoma (HP:0002884)2.07040177
41Neoplasm of the heart (HP:0100544)2.04997055
42Nephronophthisis (HP:0000090)2.04809684
43Glioma (HP:0009733)2.03256141
44Hypoplasia of the pons (HP:0012110)2.02321902
45Small hand (HP:0200055)2.01806872
46Neoplasm of striated muscle (HP:0009728)2.01517503
47Chromsome breakage (HP:0040012)1.98825916
48Morphological abnormality of the pyramidal tract (HP:0002062)1.98708280
49Urinary urgency (HP:0000012)1.97695757
50Impaired vibratory sensation (HP:0002495)1.96954528
51Genital tract atresia (HP:0001827)1.95454819
52Aplasia/Hypoplasia of the uvula (HP:0010293)1.93776593
53Action tremor (HP:0002345)1.93037219
54Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92610473
55Tented upper lip vermilion (HP:0010804)1.91017675
56Vaginal atresia (HP:0000148)1.90421262
57Oligodactyly (hands) (HP:0001180)1.90379504
58Abnormality of the renal medulla (HP:0100957)1.87323016
59Myelomeningocele (HP:0002475)1.86424997
60Truncal obesity (HP:0001956)1.84504906
61True hermaphroditism (HP:0010459)1.84227470
62Abnormality of the pons (HP:0007361)1.82903549
63Type II lissencephaly (HP:0007260)1.82861429
64Epileptiform EEG discharges (HP:0011182)1.82514232
65Gait imbalance (HP:0002141)1.81893505
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.81666950
67Medial flaring of the eyebrow (HP:0010747)1.80681834
68Hypoplastic labia majora (HP:0000059)1.80178179
69Absent speech (HP:0001344)1.78273469
70Cutaneous finger syndactyly (HP:0010554)1.77524634
71Thyroid carcinoma (HP:0002890)1.77220056
72Vertebral arch anomaly (HP:0008438)1.76246204
73Inappropriate behavior (HP:0000719)1.75186866
74Sloping forehead (HP:0000340)1.74814010
75Abnormality of the renal cortex (HP:0011035)1.74660868
76Decreased lacrimation (HP:0000633)1.73927714
77Birth length less than 3rd percentile (HP:0003561)1.73045579
78Abnormality of the labia majora (HP:0012881)1.72608386
79Colon cancer (HP:0003003)1.72481699
80Rhabdomyosarcoma (HP:0002859)1.70769812
81Congenital primary aphakia (HP:0007707)1.70571179
82Poor eye contact (HP:0000817)1.69679127
83Cupped ear (HP:0000378)1.69062155
84Ectopic kidney (HP:0000086)1.68782862
85EEG with generalized epileptiform discharges (HP:0011198)1.68541445
86Abnormality of the 4th metacarpal (HP:0010012)1.68281106
87Nephrogenic diabetes insipidus (HP:0009806)1.68253614
88Calf muscle hypertrophy (HP:0008981)1.67611025
89Generalized tonic-clonic seizures (HP:0002069)1.67353420
90Spastic gait (HP:0002064)1.66865460
91Poor coordination (HP:0002370)1.65853414
92Oral leukoplakia (HP:0002745)1.65152674
93Abnormality of the ileum (HP:0001549)1.64079846
94Inability to walk (HP:0002540)1.63355715
95Heterotopia (HP:0002282)1.63301373
96Hypsarrhythmia (HP:0002521)1.62716902
97Bifid tongue (HP:0010297)1.60105741
98Pheochromocytoma (HP:0002666)1.58698151
99Abnormality of salivation (HP:0100755)1.57621048
100Generalized hypopigmentation of hair (HP:0011358)1.57495595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.80615660
2CASK3.68935065
3MAP2K73.56363504
4FRK3.10285480
5AKT32.68926320
6MAP2K42.55689710
7MARK12.54619152
8EPHA42.43047738
9ZAK2.37145633
10ACVR1B2.26856306
11MAPK132.02343660
12BRD41.97174671
13BMPR1B1.89898176
14WNK31.72989619
15NTRK31.69191390
16MKNK21.67426382
17STK38L1.66883794
18SGK21.66373100
19TNIK1.59244946
20TLK11.44535609
21BLK1.30133396
22CAMK1G1.27354778
23SGK4941.22660903
24SGK2231.22660903
25TRIM281.12377001
26PLK21.10815901
27MKNK11.08848236
28PNCK1.05685540
29CDC71.04596081
30CAMK41.03851287
31ERBB31.03754064
32PLK41.02297717
33NTRK21.02110202
34BCR0.99554914
35PIK3CA0.97485722
36CAMK1D0.95230114
37CAMKK20.91513943
38BRSK20.91495190
39LATS10.90382178
40CSNK1G20.89810594
41CSNK1A1L0.89195829
42MAP4K20.89160887
43SGK30.88442145
44WNK10.85045321
45RET0.83050742
46PINK10.82567376
47NEK60.82332397
48PAK30.79078909
49STK390.78249054
50VRK10.76043852
51EPHA30.75561360
52INSRR0.75399139
53FGFR20.73911957
54NUAK10.73026058
55OBSCN0.72779320
56DYRK1A0.69890030
57CSNK1G10.68569593
58ATM0.68077130
59SGK10.67259627
60UHMK10.62224210
61MAP3K60.61781016
62KSR10.60443448
63PRKCE0.59448472
64PKN20.57330665
65OXSR10.56412939
66CAMK2A0.54564317
67FGFR10.52781559
68CDK50.51943088
69STK110.51930923
70ATR0.51888031
71STK380.51794966
72PBK0.50484746
73STK30.49179357
74STK40.49175026
75MINK10.48514034
76SRPK10.48252780
77CAMK2B0.48008717
78PRKAA10.47257463
79CSNK1D0.46829818
80PKN10.45735927
81YES10.45665684
82FER0.44761659
83CCNB10.44231743
84RPS6KA30.43747297
85CSNK1E0.43702294
86PRKCH0.43640311
87PTK2B0.43636117
88PRKCG0.43538559
89RPS6KA50.43021729
90GRK10.42518170
91RPS6KB10.42129961
92DYRK30.42079516
93CDK30.41922340
94PLK10.40726437
95PDGFRB0.40527234
96CAMK10.40313317
97PLK30.39289957
98NEK90.38881063
99PRKACB0.38057381
100MAPK100.37964857

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35917629
2Systemic lupus erythematosus_Homo sapiens_hsa053223.00906975
3Alcoholism_Homo sapiens_hsa050342.88795500
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45484999
5Taste transduction_Homo sapiens_hsa047422.23009803
6GABAergic synapse_Homo sapiens_hsa047272.15783209
7Morphine addiction_Homo sapiens_hsa050322.05159877
8Fanconi anemia pathway_Homo sapiens_hsa034601.95760156
9Circadian entrainment_Homo sapiens_hsa047131.93080449
10Glutamatergic synapse_Homo sapiens_hsa047241.91745782
11Insulin secretion_Homo sapiens_hsa049111.81466338
12Non-homologous end-joining_Homo sapiens_hsa034501.61951230
13Long-term potentiation_Homo sapiens_hsa047201.61426824
14Dopaminergic synapse_Homo sapiens_hsa047281.58439271
15Amphetamine addiction_Homo sapiens_hsa050311.50251851
16Salivary secretion_Homo sapiens_hsa049701.41127490
17cAMP signaling pathway_Homo sapiens_hsa040241.32658528
18Oocyte meiosis_Homo sapiens_hsa041141.32487569
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29478842
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25076664
21Renin secretion_Homo sapiens_hsa049241.24764409
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23585434
23Gastric acid secretion_Homo sapiens_hsa049711.23550233
24Cholinergic synapse_Homo sapiens_hsa047251.22331272
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21474240
26Hedgehog signaling pathway_Homo sapiens_hsa043401.18782503
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18323520
28Circadian rhythm_Homo sapiens_hsa047101.16981836
29Pancreatic secretion_Homo sapiens_hsa049721.13573823
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12605572
31Synaptic vesicle cycle_Homo sapiens_hsa047211.12567798
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12180289
33Basal transcription factors_Homo sapiens_hsa030221.10265813
34Calcium signaling pathway_Homo sapiens_hsa040201.09954240
35Long-term depression_Homo sapiens_hsa047301.09371463
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05722284
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03297604
38Wnt signaling pathway_Homo sapiens_hsa043101.00489714
39TGF-beta signaling pathway_Homo sapiens_hsa043500.98815062
40Homologous recombination_Homo sapiens_hsa034400.98159715
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97835913
42Colorectal cancer_Homo sapiens_hsa052100.96737014
43Fatty acid biosynthesis_Homo sapiens_hsa000610.96065102
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94205687
45Axon guidance_Homo sapiens_hsa043600.93999083
46Olfactory transduction_Homo sapiens_hsa047400.93371564
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93288408
48Propanoate metabolism_Homo sapiens_hsa006400.93070855
49Type II diabetes mellitus_Homo sapiens_hsa049300.92992745
50Cocaine addiction_Homo sapiens_hsa050300.92707971
51mRNA surveillance pathway_Homo sapiens_hsa030150.92557681
52ErbB signaling pathway_Homo sapiens_hsa040120.89807948
53Basal cell carcinoma_Homo sapiens_hsa052170.89621158
54Lysine degradation_Homo sapiens_hsa003100.88998849
55Cell cycle_Homo sapiens_hsa041100.87751659
56Oxytocin signaling pathway_Homo sapiens_hsa049210.86727274
57Dorso-ventral axis formation_Homo sapiens_hsa043200.86436615
58Viral carcinogenesis_Homo sapiens_hsa052030.85244306
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84972313
60Gap junction_Homo sapiens_hsa045400.84702805
61Thyroid hormone synthesis_Homo sapiens_hsa049180.83787893
62Hippo signaling pathway_Homo sapiens_hsa043900.83263381
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81336327
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80742976
65Butanoate metabolism_Homo sapiens_hsa006500.79366035
66RNA degradation_Homo sapiens_hsa030180.78184305
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76944094
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76934068
69Selenocompound metabolism_Homo sapiens_hsa004500.76876451
70Melanogenesis_Homo sapiens_hsa049160.75940002
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75160933
72Glioma_Homo sapiens_hsa052140.74971489
73GnRH signaling pathway_Homo sapiens_hsa049120.71985712
74Inositol phosphate metabolism_Homo sapiens_hsa005620.71478941
75Serotonergic synapse_Homo sapiens_hsa047260.69556031
76Ether lipid metabolism_Homo sapiens_hsa005650.67755988
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67077252
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.66210231
79Regulation of autophagy_Homo sapiens_hsa041400.65130181
80Choline metabolism in cancer_Homo sapiens_hsa052310.63869006
81FoxO signaling pathway_Homo sapiens_hsa040680.63571662
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63463903
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61138029
84RNA transport_Homo sapiens_hsa030130.58153089
85Adherens junction_Homo sapiens_hsa045200.56149551
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54893969
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54671863
88Nucleotide excision repair_Homo sapiens_hsa034200.54569098
89mTOR signaling pathway_Homo sapiens_hsa041500.54357291
90Phototransduction_Homo sapiens_hsa047440.53827025
91MicroRNAs in cancer_Homo sapiens_hsa052060.53756508
92Estrogen signaling pathway_Homo sapiens_hsa049150.52935138
93ABC transporters_Homo sapiens_hsa020100.52922603
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52796660
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51451498
96Tight junction_Homo sapiens_hsa045300.49182624
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48353147
98Steroid biosynthesis_Homo sapiens_hsa001000.46423471
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45789174
100Dilated cardiomyopathy_Homo sapiens_hsa054140.45337984

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