ZNF639

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.75739330
2interkinetic nuclear migration (GO:0022027)3.88875153
3fucose catabolic process (GO:0019317)3.80749969
4L-fucose metabolic process (GO:0042354)3.80749969
5L-fucose catabolic process (GO:0042355)3.80749969
6regulation of nuclear cell cycle DNA replication (GO:0033262)3.80158419
7protein K11-linked deubiquitination (GO:0035871)3.76229410
8rRNA catabolic process (GO:0016075)3.65877688
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.53371696
10kynurenine metabolic process (GO:0070189)3.50487890
11reciprocal DNA recombination (GO:0035825)3.45743318
12reciprocal meiotic recombination (GO:0007131)3.45743318
13pseudouridine synthesis (GO:0001522)3.44833311
14protein import into peroxisome matrix (GO:0016558)3.40926097
15replication fork processing (GO:0031297)3.40348917
16preassembly of GPI anchor in ER membrane (GO:0016254)3.19678893
17tryptophan catabolic process (GO:0006569)3.12576380
18indole-containing compound catabolic process (GO:0042436)3.12576380
19indolalkylamine catabolic process (GO:0046218)3.12576380
20DNA replication checkpoint (GO:0000076)3.11751604
21negative regulation of telomere maintenance (GO:0032205)3.10721331
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02104574
23regulation of DNA endoreduplication (GO:0032875)3.02053967
24synapsis (GO:0007129)3.01555835
25recombinational repair (GO:0000725)3.00677901
26meiotic chromosome segregation (GO:0045132)2.99166378
27double-strand break repair via homologous recombination (GO:0000724)2.98074241
28maturation of 5.8S rRNA (GO:0000460)2.94723023
29regulation of telomere maintenance (GO:0032204)2.92991617
30DNA double-strand break processing (GO:0000729)2.89700800
31regulation of centriole replication (GO:0046599)2.89552477
32DNA deamination (GO:0045006)2.85505242
33protein K63-linked deubiquitination (GO:0070536)2.82468058
34positive regulation of immune response to tumor cell (GO:0002839)2.81612931
35regulation of immune response to tumor cell (GO:0002837)2.81612931
36regulation of response to tumor cell (GO:0002834)2.81612931
37positive regulation of response to tumor cell (GO:0002836)2.81612931
38protein-cofactor linkage (GO:0018065)2.80198608
39positive regulation of histone H3-K4 methylation (GO:0051571)2.79031844
40negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.78759278
41response to pheromone (GO:0019236)2.78398363
42histone H3-K9 methylation (GO:0051567)2.77428784
43replicative senescence (GO:0090399)2.77234406
44tryptophan metabolic process (GO:0006568)2.75862765
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75538938
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.75538938
47NADH dehydrogenase complex assembly (GO:0010257)2.75538938
48necroptotic process (GO:0070266)2.75348991
49protein K48-linked deubiquitination (GO:0071108)2.73293114
50piRNA metabolic process (GO:0034587)2.73280225
51monoubiquitinated protein deubiquitination (GO:0035520)2.71132581
52histone-serine phosphorylation (GO:0035404)2.71061286
53maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70635895
54protein K6-linked ubiquitination (GO:0085020)2.69444852
55DNA demethylation (GO:0080111)2.66450690
56indolalkylamine metabolic process (GO:0006586)2.62452794
57regulation of centrosome duplication (GO:0010824)2.62417804
58mitochondrial RNA metabolic process (GO:0000959)2.61268902
59cellular response to ATP (GO:0071318)2.60966744
60regulation of centrosome cycle (GO:0046605)2.60266732
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58160407
62respiratory chain complex IV assembly (GO:0008535)2.57993382
63peptidyl-threonine dephosphorylation (GO:0035970)2.57417427
64maturation of SSU-rRNA (GO:0030490)2.56623245
65sister chromatid cohesion (GO:0007062)2.54843288
66spliceosomal complex assembly (GO:0000245)2.53892008
67cellular ketone body metabolic process (GO:0046950)2.51126454
68mitochondrial respiratory chain complex assembly (GO:0033108)2.47210762
69telomere maintenance via telomerase (GO:0007004)2.45851728
70protein sumoylation (GO:0016925)2.44696005
71tRNA processing (GO:0008033)2.44344085
72regulation of histone H3-K9 methylation (GO:0051570)2.43818506
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43540130
74regulation of mitotic spindle checkpoint (GO:1903504)2.43540130
75tRNA modification (GO:0006400)2.42222119
76male meiosis I (GO:0007141)2.39707870
77sulfation (GO:0051923)2.38588534
78translesion synthesis (GO:0019985)2.38026964
79nephron epithelium morphogenesis (GO:0072088)2.36724877
80nephron tubule morphogenesis (GO:0072078)2.36724877
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35616155
82chromatin remodeling at centromere (GO:0031055)2.35153691
83negative regulation of cell aging (GO:0090344)2.35034336
84signal peptide processing (GO:0006465)2.34691287
85regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.34485070
86prenylation (GO:0097354)2.33875718
87protein prenylation (GO:0018342)2.33875718
88rRNA methylation (GO:0031167)2.33549881
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.33144252
90negative regulation of translation, ncRNA-mediated (GO:0040033)2.33144252
91regulation of translation, ncRNA-mediated (GO:0045974)2.33144252
92DNA methylation involved in gamete generation (GO:0043046)2.33016353
93mitotic sister chromatid cohesion (GO:0007064)2.32421186
94DNA catabolic process, exonucleolytic (GO:0000738)2.32295240
95kidney morphogenesis (GO:0060993)2.32226732
96protein complex biogenesis (GO:0070271)2.32036442
97intracellular protein transmembrane import (GO:0044743)2.31542018
98reflex (GO:0060004)2.31284627
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.30917245
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.30917245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.87890765
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.77422592
3ZNF274_21170338_ChIP-Seq_K562_Hela3.73193485
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.90213424
5VDR_22108803_ChIP-Seq_LS180_Human2.89322485
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87560196
7E2F7_22180533_ChIP-Seq_HELA_Human2.84230387
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79166742
9EWS_26573619_Chip-Seq_HEK293_Human2.58099792
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53104700
11FUS_26573619_Chip-Seq_HEK293_Human2.50545485
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48724504
13GBX2_23144817_ChIP-Seq_PC3_Human2.47662729
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36370706
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25633832
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20673060
17IGF1R_20145208_ChIP-Seq_DFB_Human2.20521983
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.16320675
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.06953057
20* ER_23166858_ChIP-Seq_MCF-7_Human1.96350174
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.96175583
22MYC_18940864_ChIP-ChIP_HL60_Human1.91522245
23GATA1_22025678_ChIP-Seq_K562_Human1.88182354
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.87274612
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86205995
26VDR_23849224_ChIP-Seq_CD4+_Human1.77681135
27IRF1_19129219_ChIP-ChIP_H3396_Human1.77489180
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75505716
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73783454
30TAF15_26573619_Chip-Seq_HEK293_Human1.72309168
31P300_19829295_ChIP-Seq_ESCs_Human1.67335858
32ELK1_19687146_ChIP-ChIP_HELA_Human1.67150788
33TP53_22573176_ChIP-Seq_HFKS_Human1.62064077
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56972381
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54937639
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51259956
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49708490
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47295698
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46198192
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41820582
41STAT3_23295773_ChIP-Seq_U87_Human1.41634262
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40312096
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31183486
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.29934923
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29057800
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27654938
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.27490985
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27190652
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.26799918
50TCF4_23295773_ChIP-Seq_U87_Human1.25285597
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24650900
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23987154
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23752569
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22802366
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19092098
56FOXP3_21729870_ChIP-Seq_TREG_Human1.17683246
57EZH2_22144423_ChIP-Seq_EOC_Human1.17546918
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.16421272
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.15912234
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14071963
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10603296
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.10603296
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.10346710
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.10300111
65CBP_20019798_ChIP-Seq_JUKART_Human1.09975626
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09975626
67BCAT_22108803_ChIP-Seq_LS180_Human1.09847202
68AR_25329375_ChIP-Seq_VCAP_Human1.08915086
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08774089
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.08025689
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07863917
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07863917
73SOX2_19829295_ChIP-Seq_ESCs_Human1.07808525
74NANOG_19829295_ChIP-Seq_ESCs_Human1.07808525
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07391633
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06968444
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06543542
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05382279
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.05363270
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04980071
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03819983
82RNF2_27304074_Chip-Seq_NSC_Mouse1.03482426
83* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03357598
84P53_22387025_ChIP-Seq_ESCs_Mouse1.02809434
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.02691490
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.01036482
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.00938928
88KDM5A_27292631_Chip-Seq_BREAST_Human1.00140157
89SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99094300
90* HOXB7_26014856_ChIP-Seq_BT474_Human0.98356574
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98026604
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97828587
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.97628387
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.97488430
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97018023
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96739992
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95445556
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95001340
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94942441
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94154602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.16069657
2MP0008877_abnormal_DNA_methylation3.27118215
3MP0008058_abnormal_DNA_repair2.69395805
4MP0004145_abnormal_muscle_electrophysio2.63666732
5MP0002009_preneoplasia2.41366766
6MP0003787_abnormal_imprinting2.27069191
7MP0002160_abnormal_reproductive_system2.25966024
8MP0000569_abnormal_digit_pigmentation2.24859646
9MP0004147_increased_porphyrin_level2.08187751
10MP0010094_abnormal_chromosome_stability2.05148373
11MP0003890_abnormal_embryonic-extraembry2.04948135
12MP0003693_abnormal_embryo_hatching2.01546562
13MP0006292_abnormal_olfactory_placode1.99243580
14MP0001986_abnormal_taste_sensitivity1.97836856
15MP0003195_calcinosis1.96226497
16MP0003646_muscle_fatigue1.95073040
17MP0005174_abnormal_tail_pigmentation1.90595734
18MP0002876_abnormal_thyroid_physiology1.89835708
19MP0000427_abnormal_hair_cycle1.77034252
20MP0002837_dystrophic_cardiac_calcinosis1.70291061
21MP0004885_abnormal_endolymph1.69231807
22MP0002102_abnormal_ear_morphology1.66048618
23MP0002928_abnormal_bile_duct1.63897809
24MP0005389_reproductive_system_phenotype1.63403157
25MP0002396_abnormal_hematopoietic_system1.58868291
26MP0005551_abnormal_eye_electrophysiolog1.57727397
27MP0004142_abnormal_muscle_tone1.56417323
28MP0000631_abnormal_neuroendocrine_gland1.54236706
29MP0005645_abnormal_hypothalamus_physiol1.53558292
30MP0005220_abnormal_exocrine_pancreas1.48773396
31MP0008872_abnormal_physiological_respon1.48297496
32MP0006072_abnormal_retinal_apoptosis1.48086700
33MP0005646_abnormal_pituitary_gland1.46855180
34MP0002938_white_spotting1.43732395
35MP0005084_abnormal_gallbladder_morpholo1.43271396
36MP0003123_paternal_imprinting1.41100985
37MP0003718_maternal_effect1.39535952
38MP0001968_abnormal_touch/_nociception1.38563561
39MP0000383_abnormal_hair_follicle1.36522240
40MP0003111_abnormal_nucleus_morphology1.34616409
41MP0005075_abnormal_melanosome_morpholog1.31755960
42MP0001919_abnormal_reproductive_system1.30165170
43MP0003077_abnormal_cell_cycle1.28623196
44MP0002163_abnormal_gland_morphology1.27546796
45MP0003943_abnormal_hepatobiliary_system1.26619945
46MP0009046_muscle_twitch1.23711670
47MP0001873_stomach_inflammation1.19776925
48MP0004043_abnormal_pH_regulation1.18257226
49MP0001485_abnormal_pinna_reflex1.17229318
50MP0003567_abnormal_fetal_cardiomyocyte1.14807940
51MP0002138_abnormal_hepatobiliary_system1.12658327
52MP0002736_abnormal_nociception_after1.10546855
53MP0004924_abnormal_behavior1.09883866
54MP0005386_behavior/neurological_phenoty1.09883866
55MP0004215_abnormal_myocardial_fiber1.06209433
56MP0002210_abnormal_sex_determination1.06057463
57MP0003937_abnormal_limbs/digits/tail_de1.05668998
58MP0005253_abnormal_eye_physiology1.04304925
59MP0003121_genomic_imprinting1.03532726
60MP0002234_abnormal_pharynx_morphology1.02416025
61MP0001188_hyperpigmentation1.01599984
62MP0001929_abnormal_gametogenesis1.01107698
63MP0008995_early_reproductive_senescence1.00937583
64MP0004957_abnormal_blastocyst_morpholog0.98686210
65MP0002095_abnormal_skin_pigmentation0.97122343
66MP0006276_abnormal_autonomic_nervous0.96841672
67MP0004130_abnormal_muscle_cell0.95962141
68MP0001145_abnormal_male_reproductive0.95536602
69MP0009745_abnormal_behavioral_response0.95420326
70MP0000372_irregular_coat_pigmentation0.93914823
71MP0003698_abnormal_male_reproductive0.91652097
72MP0008007_abnormal_cellular_replicative0.91053126
73MP0005266_abnormal_metabolism0.89707979
74MP0002272_abnormal_nervous_system0.89021383
75MP0004808_abnormal_hematopoietic_stem0.87436108
76MP0010678_abnormal_skin_adnexa0.87215329
77MP0001286_abnormal_eye_development0.86692795
78MP0004133_heterotaxia0.86573323
79MP0003786_premature_aging0.86252172
80MP0005187_abnormal_penis_morphology0.85211937
81MP0000653_abnormal_sex_gland0.84910763
82MP0005083_abnormal_biliary_tract0.84676261
83MP0002638_abnormal_pupillary_reflex0.84439153
84MP0008775_abnormal_heart_ventricle0.83559356
85MP0009697_abnormal_copulation0.82640448
86MP0001944_abnormal_pancreas_morphology0.82289520
87MP0010386_abnormal_urinary_bladder0.80159231
88MP0001501_abnormal_sleep_pattern0.79321984
89MP0002693_abnormal_pancreas_physiology0.78781974
90MP0000470_abnormal_stomach_morphology0.78084007
91MP0008961_abnormal_basal_metabolism0.74283410
92MP0001293_anophthalmia0.73113819
93MP0010307_abnormal_tumor_latency0.71120539
94MP0002067_abnormal_sensory_capabilities0.70560888
95MP0009250_abnormal_appendicular_skeleto0.70127866
96MP0002557_abnormal_social/conspecific_i0.69600196
97MP0003119_abnormal_digestive_system0.69402953
98MP0005379_endocrine/exocrine_gland_phen0.68806451
99MP0005195_abnormal_posterior_eye0.65372038
100MP0000230_abnormal_systemic_arterial0.63835032

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.73171475
2Pancreatic cysts (HP:0001737)3.72203946
3Birth length less than 3rd percentile (HP:0003561)3.67949265
4Abnormality of alanine metabolism (HP:0010916)3.66508705
5Hyperalaninemia (HP:0003348)3.66508705
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.66508705
7Genetic anticipation (HP:0003743)3.55970084
8Attenuation of retinal blood vessels (HP:0007843)3.26222621
9Molar tooth sign on MRI (HP:0002419)3.22082342
10Abnormality of midbrain morphology (HP:0002418)3.22082342
11Abnormality of the renal cortex (HP:0011035)3.14543567
12Pancreatic fibrosis (HP:0100732)2.92513823
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92399070
14Chromsome breakage (HP:0040012)2.83563050
15Stomach cancer (HP:0012126)2.82155751
16Protruding tongue (HP:0010808)2.72769340
17Nephronophthisis (HP:0000090)2.72560841
18Renal cortical cysts (HP:0000803)2.67097119
19Abnormal number of erythroid precursors (HP:0012131)2.62897108
20Abnormality of the renal medulla (HP:0100957)2.59264357
21Acute lymphatic leukemia (HP:0006721)2.58944197
22Constricted visual fields (HP:0001133)2.58673981
23True hermaphroditism (HP:0010459)2.56035727
24Duplicated collecting system (HP:0000081)2.51504922
25Progressive cerebellar ataxia (HP:0002073)2.50990158
26Gaze-evoked nystagmus (HP:0000640)2.49415481
27Patellar aplasia (HP:0006443)2.47756388
28Abnormality of cells of the erythroid lineage (HP:0012130)2.47376929
29Abnormality of the pons (HP:0007361)2.47131168
30Fair hair (HP:0002286)2.45683009
31Abnormality of the renal collecting system (HP:0004742)2.45593046
32Hyperventilation (HP:0002883)2.41941260
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.41775627
34Chronic hepatic failure (HP:0100626)2.41371742
35Clumsiness (HP:0002312)2.40193843
36Aplasia/Hypoplasia of the patella (HP:0006498)2.36776270
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35990581
38Type II lissencephaly (HP:0007260)2.35925597
39Neoplasm of the adrenal cortex (HP:0100641)2.30347897
40Short chin (HP:0000331)2.28709166
41Tubular atrophy (HP:0000092)2.24251160
42Volvulus (HP:0002580)2.23788683
43Abnormality of chromosome stability (HP:0003220)2.22506520
44Large for gestational age (HP:0001520)2.18731853
45Concave nail (HP:0001598)2.18654495
46Hypoplasia of the pons (HP:0012110)2.17582108
47Abnormal rod and cone electroretinograms (HP:0008323)2.16731839
48Abnormal drinking behavior (HP:0030082)2.13883309
49Polydipsia (HP:0001959)2.13883309
50Abolished electroretinogram (ERG) (HP:0000550)2.11632588
51Broad-based gait (HP:0002136)2.10972996
52Chorioretinal atrophy (HP:0000533)2.10624712
53Pendular nystagmus (HP:0012043)2.09765658
54Decreased circulating renin level (HP:0003351)2.06939903
55Acute myeloid leukemia (HP:0004808)2.04860706
56Absent thumb (HP:0009777)2.04414192
57Abnormality of the preputium (HP:0100587)2.03187073
58Medial flaring of the eyebrow (HP:0010747)2.01989105
59Meckel diverticulum (HP:0002245)2.00573051
60Abnormality of the ileum (HP:0001549)1.96831481
61Furrowed tongue (HP:0000221)1.96212639
62Colon cancer (HP:0003003)1.95853910
63Congenital, generalized hypertrichosis (HP:0004540)1.93510510
64Clubbing of toes (HP:0100760)1.92276643
65Cerebellar dysplasia (HP:0007033)1.91547078
66Generalized hypopigmentation of hair (HP:0011358)1.86656581
67Sloping forehead (HP:0000340)1.85395031
68Partial agenesis of the corpus callosum (HP:0001338)1.84192932
69Inability to walk (HP:0002540)1.80937274
70Abnormal pancreas size (HP:0012094)1.80208247
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78790201
72Bilateral microphthalmos (HP:0007633)1.78439583
73Progressive inability to walk (HP:0002505)1.78046710
74Hypoplastic iliac wings (HP:0002866)1.77564781
75Bile duct proliferation (HP:0001408)1.75687931
76Abnormal biliary tract physiology (HP:0012439)1.75687931
77Muscle hypertrophy of the lower extremities (HP:0008968)1.75415661
78Bony spicule pigmentary retinopathy (HP:0007737)1.75049838
79Abnormality of the carotid arteries (HP:0005344)1.74998496
80Cystic liver disease (HP:0006706)1.74086012
81Lipid accumulation in hepatocytes (HP:0006561)1.72321327
82Reticulocytopenia (HP:0001896)1.69974555
83Increased hepatocellular lipid droplets (HP:0006565)1.67718230
84Ectopic kidney (HP:0000086)1.67344044
85Sclerocornea (HP:0000647)1.67324866
863-Methylglutaconic aciduria (HP:0003535)1.66526844
87Brushfield spots (HP:0001088)1.66082359
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.65801420
89Aplasia/hypoplasia of the uterus (HP:0008684)1.65739063
90Small hand (HP:0200055)1.65236877
91Meningioma (HP:0002858)1.63719586
92Breast hypoplasia (HP:0003187)1.63068005
93Supernumerary spleens (HP:0009799)1.62885181
94Abnormality of B cell number (HP:0010975)1.62669148
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62563610
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61084132
97Tachypnea (HP:0002789)1.61083363
98Triphalangeal thumb (HP:0001199)1.58701751
99Optic disc pallor (HP:0000543)1.57202170
100Female pseudohermaphroditism (HP:0010458)1.52391224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.15526273
2BMPR1B3.75909096
3TLK13.45176800
4ZAK3.08261686
5TRPM72.74815793
6MKNK22.47753334
7NUAK12.45445067
8ADRBK22.25764450
9ACVR1B2.25277402
10WNK42.19578040
11EIF2AK32.18008546
12CDC71.98901982
13TGFBR11.95648267
14GRK11.95128133
15MKNK11.80989045
16BRSK21.73059617
17CAMKK21.46570895
18WEE11.40683088
19MAP3K101.39923486
20WNK31.37938948
21PASK1.37082504
22TEC1.32850216
23PNCK1.32018632
24INSRR1.22898323
25NEK21.22462476
26TAF11.20696636
27CHEK21.10241810
28OXSR11.09387282
29MAPK131.04946562
30TAOK31.04732127
31STK391.04660107
32MAP3K41.04640562
33KIT1.04195141
34MAP4K21.02630687
35TSSK61.00384039
36PINK10.99170503
37FLT30.96872547
38RPS6KB20.93989240
39TXK0.93987869
40ADRBK10.92584189
41TRIM280.92543232
42FGFR20.91517412
43AKT30.90088018
44PLK30.89679645
45STK30.89030789
46VRK10.86197088
47STK160.83657595
48ATR0.83647561
49PLK40.83437549
50IRAK10.78246789
51EIF2AK20.73380687
52STK38L0.72045184
53PLK10.71885957
54PIK3CA0.71061914
55SRPK10.70424651
56BUB10.69256711
57OBSCN0.67540021
58CDK80.64628156
59IKBKB0.64337464
60TNIK0.64294868
61RPS6KA50.61838174
62ATM0.61780978
63DAPK20.57005996
64PLK20.53904793
65RPS6KA60.52729140
66ITK0.50521712
67SIK20.49107975
68NLK0.48040644
69ERBB30.47626481
70TTK0.47433178
71ILK0.45419396
72CHEK10.45020938
73PRKCI0.43974598
74CHUK0.43182114
75BRD40.41674476
76STK110.41594936
77SGK20.41594903
78MAPKAPK30.41172792
79CASK0.40612602
80EIF2AK10.40293399
81CSNK1D0.39938877
82WNK10.39615720
83PAK30.39282312
84STK240.38699146
85MAPKAPK50.38187916
86PIM10.37886587
87CDK30.37646903
88MAP2K20.37108827
89PDK20.36820907
90PRKCG0.36508560
91CAMKK10.35956177
92MELK0.35849901
93PRKCQ0.35491676
94PRKCE0.34984215
95MAPK110.32525074
96CDK40.32263694
97BMPR20.31954136
98MAP2K10.31913206
99EEF2K0.30986272
100CSNK1E0.30041067

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.12160175
2Homologous recombination_Homo sapiens_hsa034402.61006607
3RNA polymerase_Homo sapiens_hsa030202.57449983
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52908759
5Basal transcription factors_Homo sapiens_hsa030222.45606622
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41396587
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.30391567
8Nitrogen metabolism_Homo sapiens_hsa009102.28497823
9Fanconi anemia pathway_Homo sapiens_hsa034602.26196470
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24665495
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20395574
12Phototransduction_Homo sapiens_hsa047442.18043907
13Ribosome_Homo sapiens_hsa030102.14235142
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12000440
15Linoleic acid metabolism_Homo sapiens_hsa005912.11939176
16RNA degradation_Homo sapiens_hsa030182.05347079
17Non-homologous end-joining_Homo sapiens_hsa034501.95369821
18One carbon pool by folate_Homo sapiens_hsa006701.89912257
19Protein export_Homo sapiens_hsa030601.59423202
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.56439647
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51591106
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47222032
23Butanoate metabolism_Homo sapiens_hsa006501.46889615
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45128795
25RNA transport_Homo sapiens_hsa030131.44784071
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44386614
27Ether lipid metabolism_Homo sapiens_hsa005651.42805800
28Nucleotide excision repair_Homo sapiens_hsa034201.27878277
29Caffeine metabolism_Homo sapiens_hsa002321.21785113
30p53 signaling pathway_Homo sapiens_hsa041151.21466906
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16706136
32DNA replication_Homo sapiens_hsa030301.16130639
33Nicotine addiction_Homo sapiens_hsa050331.13812106
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08791791
35Taste transduction_Homo sapiens_hsa047421.03716359
36Cell cycle_Homo sapiens_hsa041101.00843929
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00317229
38Asthma_Homo sapiens_hsa053100.99129212
39Pyrimidine metabolism_Homo sapiens_hsa002400.97318371
40Tryptophan metabolism_Homo sapiens_hsa003800.97152070
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97094509
42Purine metabolism_Homo sapiens_hsa002300.96773087
43ABC transporters_Homo sapiens_hsa020100.95097094
44Oxidative phosphorylation_Homo sapiens_hsa001900.94086181
45Base excision repair_Homo sapiens_hsa034100.92031796
46Dorso-ventral axis formation_Homo sapiens_hsa043200.90814364
47Systemic lupus erythematosus_Homo sapiens_hsa053220.89157729
48Olfactory transduction_Homo sapiens_hsa047400.88943930
49Spliceosome_Homo sapiens_hsa030400.87060387
50Type I diabetes mellitus_Homo sapiens_hsa049400.86820533
51Morphine addiction_Homo sapiens_hsa050320.82785363
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76491345
53Peroxisome_Homo sapiens_hsa041460.72608509
54Serotonergic synapse_Homo sapiens_hsa047260.72070906
55mRNA surveillance pathway_Homo sapiens_hsa030150.71358847
56Lysine degradation_Homo sapiens_hsa003100.71253347
57Primary immunodeficiency_Homo sapiens_hsa053400.69344869
58Calcium signaling pathway_Homo sapiens_hsa040200.65083771
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64720215
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64640393
61Propanoate metabolism_Homo sapiens_hsa006400.64563228
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62972759
63Long-term depression_Homo sapiens_hsa047300.61725371
64Insulin secretion_Homo sapiens_hsa049110.60594958
65Parkinsons disease_Homo sapiens_hsa050120.60181114
66Mismatch repair_Homo sapiens_hsa034300.59635165
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59593054
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59091042
69Allograft rejection_Homo sapiens_hsa053300.56930997
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56472943
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.56341589
72Cardiac muscle contraction_Homo sapiens_hsa042600.55041441
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53820555
74Huntingtons disease_Homo sapiens_hsa050160.53808968
75Sulfur relay system_Homo sapiens_hsa041220.53234417
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.52739490
77Circadian entrainment_Homo sapiens_hsa047130.50805368
78Circadian rhythm_Homo sapiens_hsa047100.49960870
79Glutamatergic synapse_Homo sapiens_hsa047240.49886616
80Ovarian steroidogenesis_Homo sapiens_hsa049130.49728483
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47633008
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46079255
83Hedgehog signaling pathway_Homo sapiens_hsa043400.41597446
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.40739753
85Alcoholism_Homo sapiens_hsa050340.40366378
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40185407
87Cholinergic synapse_Homo sapiens_hsa047250.39819451
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38379871
89Melanoma_Homo sapiens_hsa052180.38354427
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37307622
91Regulation of autophagy_Homo sapiens_hsa041400.37286879
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36494969
93Basal cell carcinoma_Homo sapiens_hsa052170.35825305
94Retinol metabolism_Homo sapiens_hsa008300.34728717
95Graft-versus-host disease_Homo sapiens_hsa053320.32310459
96Alzheimers disease_Homo sapiens_hsa050100.31602047
97Fat digestion and absorption_Homo sapiens_hsa049750.31470516
98Oxytocin signaling pathway_Homo sapiens_hsa049210.30567161
99African trypanosomiasis_Homo sapiens_hsa051430.30095497
100TGF-beta signaling pathway_Homo sapiens_hsa043500.29826375

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