ZNF644

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.80212986
2mitotic sister chromatid cohesion (GO:0007064)4.33820018
3regulation of DNA endoreduplication (GO:0032875)4.10472122
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.06686599
5nuclear pore complex assembly (GO:0051292)4.00372425
6nuclear pore organization (GO:0006999)3.98616306
7replication fork processing (GO:0031297)3.85302908
8neural tube formation (GO:0001841)3.82681276
9regulation of centriole replication (GO:0046599)3.72845139
10negative regulation of DNA recombination (GO:0045910)3.56348438
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48369205
12regulation of mitotic spindle checkpoint (GO:1903504)3.48369205
13kinetochore organization (GO:0051383)3.44634007
14microtubule depolymerization (GO:0007019)3.43702355
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41176600
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.41176600
17regulation of translation, ncRNA-mediated (GO:0045974)3.41176600
18chromatin remodeling at centromere (GO:0031055)3.37304700
19limb bud formation (GO:0060174)3.30944897
20CENP-A containing nucleosome assembly (GO:0034080)3.29172425
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24457246
22non-recombinational repair (GO:0000726)3.22994687
23double-strand break repair via nonhomologous end joining (GO:0006303)3.22994687
24presynaptic membrane assembly (GO:0097105)3.18934220
25microtubule anchoring (GO:0034453)3.18748920
26sister chromatid cohesion (GO:0007062)3.15483467
27centriole replication (GO:0007099)3.08843400
28monoubiquitinated protein deubiquitination (GO:0035520)3.06518944
29somite development (GO:0061053)3.06283988
30regulation of centrosome duplication (GO:0010824)3.05744162
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04422861
32recombinational repair (GO:0000725)3.03581097
33intraciliary transport (GO:0042073)3.02600604
34double-strand break repair via homologous recombination (GO:0000724)3.02185824
35kinetochore assembly (GO:0051382)3.01581468
36resolution of meiotic recombination intermediates (GO:0000712)3.00824474
37pre-miRNA processing (GO:0031054)3.00816322
38histone exchange (GO:0043486)2.98137093
39meiotic chromosome segregation (GO:0045132)2.97874670
40postreplication repair (GO:0006301)2.96939248
41protein K11-linked deubiquitination (GO:0035871)2.93661039
42pore complex assembly (GO:0046931)2.88705105
43metaphase plate congression (GO:0051310)2.87899131
44olfactory bulb development (GO:0021772)2.86516788
45somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85968948
46somatic hypermutation of immunoglobulin genes (GO:0016446)2.85968948
47microtubule polymerization or depolymerization (GO:0031109)2.85876673
48presynaptic membrane organization (GO:0097090)2.84139169
49response to X-ray (GO:0010165)2.83491460
50spindle checkpoint (GO:0031577)2.83301838
51regulation of helicase activity (GO:0051095)2.81804470
52histone mRNA metabolic process (GO:0008334)2.80776447
53protein prenylation (GO:0018342)2.80701552
54prenylation (GO:0097354)2.80701552
55regulation of centrosome cycle (GO:0046605)2.79466362
56ncRNA catabolic process (GO:0034661)2.78929779
57response to pheromone (GO:0019236)2.77907062
58mitotic spindle checkpoint (GO:0071174)2.77146742
59negative regulation of sister chromatid segregation (GO:0033046)2.75140872
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75140872
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75140872
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75140872
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.75140872
64regulation of sister chromatid segregation (GO:0033045)2.73907575
65regulation of mitotic sister chromatid separation (GO:0010965)2.73907575
66regulation of mitotic sister chromatid segregation (GO:0033047)2.73907575
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73458941
68regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73458941
69histone H2A acetylation (GO:0043968)2.73239991
70mitotic G2/M transition checkpoint (GO:0044818)2.73012262
71regulation of meiosis I (GO:0060631)2.72241524
72pyrimidine nucleobase catabolic process (GO:0006208)2.71792922
73DNA replication-dependent nucleosome assembly (GO:0006335)2.69899494
74DNA replication-dependent nucleosome organization (GO:0034723)2.69899494
75negative regulation of chromosome segregation (GO:0051985)2.68182360
76DNA replication-independent nucleosome organization (GO:0034724)2.66880571
77DNA replication-independent nucleosome assembly (GO:0006336)2.66880571
78establishment of protein localization to Golgi (GO:0072600)2.66225332
79L-fucose catabolic process (GO:0042355)2.65972921
80fucose catabolic process (GO:0019317)2.65972921
81L-fucose metabolic process (GO:0042354)2.65972921
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.64615506
83mechanosensory behavior (GO:0007638)2.63003564
84synapsis (GO:0007129)2.62825131
85sister chromatid segregation (GO:0000819)2.61969977
86rRNA catabolic process (GO:0016075)2.59403970
87mitotic spindle assembly checkpoint (GO:0007094)2.59261119
88spindle assembly checkpoint (GO:0071173)2.57317413
89microtubule organizing center organization (GO:0031023)2.56574932
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56207701
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56207701
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.56207701
93acrosome assembly (GO:0001675)2.55909178
94DNA catabolic process, exonucleolytic (GO:0000738)2.55428299
95peptidyl-lysine trimethylation (GO:0018023)2.54482863
96nonmotile primary cilium assembly (GO:0035058)2.53270930
97regulation of sarcomere organization (GO:0060297)2.53244010
98regulation of sister chromatid cohesion (GO:0007063)2.49939434
99histone mRNA catabolic process (GO:0071044)2.46898422
100centrosome organization (GO:0051297)2.46400383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.91398623
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.05880088
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.80350491
4FUS_26573619_Chip-Seq_HEK293_Human2.74483473
5TAF15_26573619_Chip-Seq_HEK293_Human2.67125303
6* EWS_26573619_Chip-Seq_HEK293_Human2.65093370
7IGF1R_20145208_ChIP-Seq_DFB_Human2.63369394
8GBX2_23144817_ChIP-Seq_PC3_Human2.63009118
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60899426
10E2F7_22180533_ChIP-Seq_HELA_Human2.59960255
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56773163
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48636913
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42046172
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17446898
15VDR_22108803_ChIP-Seq_LS180_Human2.11777804
16* P300_19829295_ChIP-Seq_ESCs_Human2.11632983
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09721221
18ELK1_19687146_ChIP-ChIP_HELA_Human2.04853779
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02937185
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01614820
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.92648858
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89899179
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88862408
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87814977
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87716325
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72547492
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72105811
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69152808
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66909038
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64790604
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64593152
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.64243788
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60828636
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59842787
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59275973
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57795629
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55291183
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.54093617
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53632486
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51342599
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50677871
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50225056
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49562852
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49543243
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.46927206
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.45681162
47* ER_23166858_ChIP-Seq_MCF-7_Human1.43803158
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.42373343
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42263565
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.40533315
51STAT3_23295773_ChIP-Seq_U87_Human1.38323382
52CBP_20019798_ChIP-Seq_JUKART_Human1.34787878
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34787878
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.34377146
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34114223
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32289812
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32289812
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31290732
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30911655
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29313948
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.28822170
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28027759
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.27889794
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25675060
65TCF4_23295773_ChIP-Seq_U87_Human1.22759261
66AR_25329375_ChIP-Seq_VCAP_Human1.22726010
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21990302
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20756275
69MYC_18940864_ChIP-ChIP_HL60_Human1.19129192
70BCAT_22108803_ChIP-Seq_LS180_Human1.19107411
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19062749
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18415893
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16526030
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15829516
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.14821520
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.14653692
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14098760
78* VDR_23849224_ChIP-Seq_CD4+_Human1.13723425
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12358891
80P53_22387025_ChIP-Seq_ESCs_Mouse1.11593878
81TCF4_22108803_ChIP-Seq_LS180_Human1.10113296
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09960645
83* E2F1_21310950_ChIP-Seq_MCF-7_Human1.08667503
84SOX9_26525672_Chip-Seq_HEART_Mouse1.07812923
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.07581327
86RNF2_27304074_Chip-Seq_NSC_Mouse1.07423469
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06261107
88IRF1_19129219_ChIP-ChIP_H3396_Human1.04923589
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.03919059
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03514917
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.03028511
92P300_18555785_Chip-Seq_ESCs_Mouse1.02820313
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02716079
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.02538948
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.99697327
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.99598502
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99419392
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.97895446
99AR_21572438_ChIP-Seq_LNCaP_Human0.97826288
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96653574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.93519363
2MP0000569_abnormal_digit_pigmentation3.61302379
3MP0008877_abnormal_DNA_methylation2.79689509
4MP0008058_abnormal_DNA_repair2.72072004
5MP0003890_abnormal_embryonic-extraembry2.50837471
6MP0010094_abnormal_chromosome_stability2.50432695
7MP0002102_abnormal_ear_morphology2.38619091
8MP0003787_abnormal_imprinting2.34344987
9MP0006292_abnormal_olfactory_placode2.11020313
10MP0002234_abnormal_pharynx_morphology1.95511946
11MP0003121_genomic_imprinting1.89115876
12MP0001293_anophthalmia1.88050095
13MP0006072_abnormal_retinal_apoptosis1.84339656
14MP0003937_abnormal_limbs/digits/tail_de1.83264111
15MP0001529_abnormal_vocalization1.79493183
16MP0000778_abnormal_nervous_system1.78357487
17MP0005253_abnormal_eye_physiology1.73537652
18MP0003693_abnormal_embryo_hatching1.71895518
19MP0002233_abnormal_nose_morphology1.69140448
20MP0003880_abnormal_central_pattern1.65975982
21MP0003567_abnormal_fetal_cardiomyocyte1.63364255
22MP0003077_abnormal_cell_cycle1.58693136
23MP0008789_abnormal_olfactory_epithelium1.58387955
24MP0004957_abnormal_blastocyst_morpholog1.58332507
25MP0003111_abnormal_nucleus_morphology1.54301225
26MP0002009_preneoplasia1.52063286
27MP0009697_abnormal_copulation1.51800499
28MP0000516_abnormal_urinary_system1.50190768
29MP0005367_renal/urinary_system_phenotyp1.50190768
30MP0005187_abnormal_penis_morphology1.48261455
31MP0000631_abnormal_neuroendocrine_gland1.47874010
32MP0002751_abnormal_autonomic_nervous1.46047310
33MP0001188_hyperpigmentation1.45841636
34MP0004742_abnormal_vestibular_system1.40747926
35MP0001984_abnormal_olfaction1.40148962
36MP0000647_abnormal_sebaceous_gland1.38738292
37MP0002938_white_spotting1.38443829
38MP0005248_abnormal_Harderian_gland1.34067569
39MP0003136_yellow_coat_color1.33237157
40MP0000427_abnormal_hair_cycle1.32606248
41MP0002736_abnormal_nociception_after1.30836923
42MP0001286_abnormal_eye_development1.30743674
43MP0008932_abnormal_embryonic_tissue1.30086453
44MP0006054_spinal_hemorrhage1.28002014
45MP0005499_abnormal_olfactory_system1.26663150
46MP0005394_taste/olfaction_phenotype1.26663150
47MP0005391_vision/eye_phenotype1.26139542
48MP0003941_abnormal_skin_development1.25318768
49MP0002697_abnormal_eye_size1.25274440
50MP0003119_abnormal_digestive_system1.24776050
51MP0001486_abnormal_startle_reflex1.22395061
52MP0002638_abnormal_pupillary_reflex1.20613580
53MP0001485_abnormal_pinna_reflex1.18389395
54MP0003755_abnormal_palate_morphology1.18012275
55MP0003718_maternal_effect1.17206202
56MP0004197_abnormal_fetal_growth/weight/1.13322455
57MP0002084_abnormal_developmental_patter1.13164717
58MP0005551_abnormal_eye_electrophysiolog1.12954781
59MP0009703_decreased_birth_body1.08235878
60MP0000383_abnormal_hair_follicle1.07696829
61MP0008007_abnormal_cellular_replicative1.05787794
62MP0006276_abnormal_autonomic_nervous1.03494180
63MP0001177_atelectasis1.03227038
64MP0004133_heterotaxia1.02208198
65MP0003786_premature_aging1.02162847
66MP0003861_abnormal_nervous_system1.01985752
67MP0000049_abnormal_middle_ear1.01578011
68MP0002184_abnormal_innervation1.01180279
69MP0003385_abnormal_body_wall0.99689944
70MP0010307_abnormal_tumor_latency0.97815604
71MP0001299_abnormal_eye_distance/0.96628271
72MP0004215_abnormal_myocardial_fiber0.96048741
73MP0003221_abnormal_cardiomyocyte_apopto0.95625639
74MP0002822_catalepsy0.94614920
75MP0003935_abnormal_craniofacial_develop0.94442813
76MP0001929_abnormal_gametogenesis0.92858809
77MP0010678_abnormal_skin_adnexa0.90200658
78MP0003938_abnormal_ear_development0.89036726
79MP0000428_abnormal_craniofacial_morphol0.88965711
80MP0000372_irregular_coat_pigmentation0.86885351
81MP0010352_gastrointestinal_tract_polyps0.86666638
82MP0001968_abnormal_touch/_nociception0.85942154
83MP0002210_abnormal_sex_determination0.84935260
84MP0002095_abnormal_skin_pigmentation0.84814043
85MP0005380_embryogenesis_phenotype0.84402013
86MP0001672_abnormal_embryogenesis/_devel0.84402013
87MP0005386_behavior/neurological_phenoty0.83499932
88MP0004924_abnormal_behavior0.83499932
89MP0002092_abnormal_eye_morphology0.82176473
90MP0002085_abnormal_embryonic_tissue0.82097700
91MP0005195_abnormal_posterior_eye0.80057356
92MP0005174_abnormal_tail_pigmentation0.79914007
93MP0003122_maternal_imprinting0.79823253
94MP0002752_abnormal_somatic_nervous0.78979669
95MP0000653_abnormal_sex_gland0.78889917
96MP0002088_abnormal_embryonic_growth/wei0.78697087
97MP0000537_abnormal_urethra_morphology0.77126524
98MP0000955_abnormal_spinal_cord0.76353384
99MP0001697_abnormal_embryo_size0.75113213
100MP0003984_embryonic_growth_retardation0.74303969

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.07772803
2Hyperventilation (HP:0002883)3.07944726
3Chromsome breakage (HP:0040012)3.05431006
4Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95540407
5Abnormality of chromosome stability (HP:0003220)2.91125710
6Papillary thyroid carcinoma (HP:0002895)2.89457601
7Colon cancer (HP:0003003)2.82944343
8Abnormality of the labia minora (HP:0012880)2.77650538
9Pancreatic cysts (HP:0001737)2.73744139
10Hepatoblastoma (HP:0002884)2.70240021
11Medulloblastoma (HP:0002885)2.66554001
12Drooling (HP:0002307)2.64094622
13Intestinal atresia (HP:0011100)2.60233089
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.59928241
15Chronic hepatic failure (HP:0100626)2.59103850
16Renal cortical cysts (HP:0000803)2.53716910
17Pancreatic fibrosis (HP:0100732)2.52662892
18Meckel diverticulum (HP:0002245)2.51721748
19Nephronophthisis (HP:0000090)2.46320490
20Abnormality of the ileum (HP:0001549)2.44097481
21Medial flaring of the eyebrow (HP:0010747)2.39970247
22True hermaphroditism (HP:0010459)2.38878038
23Genital tract atresia (HP:0001827)2.36444942
24Excessive salivation (HP:0003781)2.34089733
25Cupped ear (HP:0000378)2.33425171
26Oligodactyly (hands) (HP:0001180)2.33141268
27Molar tooth sign on MRI (HP:0002419)2.31016179
28Abnormality of midbrain morphology (HP:0002418)2.31016179
29Abnormality of the renal cortex (HP:0011035)2.30924103
30Abnormality of the renal medulla (HP:0100957)2.29041051
31Vaginal atresia (HP:0000148)2.27028578
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.23833626
33Embryonal renal neoplasm (HP:0011794)2.23491649
34Congenital primary aphakia (HP:0007707)2.23440449
35Bifid tongue (HP:0010297)2.23187946
36Nephroblastoma (Wilms tumor) (HP:0002667)2.21862224
37Protruding tongue (HP:0010808)2.19928044
38Gait imbalance (HP:0002141)2.19288238
39Glioma (HP:0009733)2.18578998
40Broad-based gait (HP:0002136)2.15133796
41Neoplasm of the oral cavity (HP:0100649)2.12819816
42Sloping forehead (HP:0000340)2.10801978
43Thyroid carcinoma (HP:0002890)2.10761213
44Nephrogenic diabetes insipidus (HP:0009806)2.10214870
45Cortical dysplasia (HP:0002539)2.02084222
46Abnormal lung lobation (HP:0002101)2.01598724
47Neoplasm of the adrenal cortex (HP:0100641)2.01580199
48Poor coordination (HP:0002370)2.00004515
49Astrocytoma (HP:0009592)1.98986228
50Abnormality of the astrocytes (HP:0100707)1.98986228
51Rhabdomyosarcoma (HP:0002859)1.96793780
52Postaxial foot polydactyly (HP:0001830)1.95852244
53Hypoplastic labia majora (HP:0000059)1.94226978
54Fair hair (HP:0002286)1.91924061
55Abnormality of the duodenum (HP:0002246)1.90544638
56Abnormality of the preputium (HP:0100587)1.90364128
57Duodenal stenosis (HP:0100867)1.89839078
58Small intestinal stenosis (HP:0012848)1.89839078
59Postaxial hand polydactyly (HP:0001162)1.87479167
60Aplasia/Hypoplasia of the tibia (HP:0005772)1.87450097
61Methylmalonic acidemia (HP:0002912)1.86859311
62Septo-optic dysplasia (HP:0100842)1.84435032
63Preaxial hand polydactyly (HP:0001177)1.84006557
64Labial hypoplasia (HP:0000066)1.82810449
65Tubulointerstitial nephritis (HP:0001970)1.80337736
66Gastrointestinal atresia (HP:0002589)1.80220849
67Abnormality of the ischium (HP:0003174)1.78544879
68Abnormality of the labia majora (HP:0012881)1.78543984
69Astigmatism (HP:0000483)1.78452136
70Ectopic kidney (HP:0000086)1.78217437
71Small hand (HP:0200055)1.77290465
72Renal hypoplasia (HP:0000089)1.76781771
73Cystic hygroma (HP:0000476)1.76621146
74Abnormality of the septum pellucidum (HP:0007375)1.75785521
75Progressive inability to walk (HP:0002505)1.75687850
76Gonadotropin excess (HP:0000837)1.74980863
77Aqueductal stenosis (HP:0002410)1.74560705
78Biliary tract neoplasm (HP:0100574)1.74520943
79Hypoplastic female external genitalia (HP:0012815)1.73948399
80Hyperglycinemia (HP:0002154)1.73801396
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.73033877
82Absent speech (HP:0001344)1.72807762
83Febrile seizures (HP:0002373)1.72467467
84Narrow forehead (HP:0000341)1.71979901
85Lissencephaly (HP:0001339)1.70700231
86Micropenis (HP:0000054)1.69440460
87Optic nerve hypoplasia (HP:0000609)1.69243047
88Widely spaced teeth (HP:0000687)1.68994691
89Clubbing of toes (HP:0100760)1.67315096
90Thyroiditis (HP:0100646)1.66636131
91Gaze-evoked nystagmus (HP:0000640)1.65471524
92Large earlobe (HP:0009748)1.63973843
93Abnormal biliary tract physiology (HP:0012439)1.63193628
94Bile duct proliferation (HP:0001408)1.63193628
95Median cleft lip (HP:0000161)1.60570316
96Acute myeloid leukemia (HP:0004808)1.60304430
97Long clavicles (HP:0000890)1.59825233
98Broad foot (HP:0001769)1.58685758
99Absent eyebrow (HP:0002223)1.58645230
100Abnormal hair whorl (HP:0010721)1.58445738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.87212704
2CASK2.68650307
3WNK32.61288691
4TRIM282.54148549
5BCR2.51946152
6TNIK2.48731424
7MKNK22.43146864
8NUAK12.33331488
9MAP3K42.23248039
10SRPK12.19817865
11ERBB32.12869736
12BRSK22.10621186
13BRD42.07552923
14EIF2AK32.01051449
15STK38L2.00352299
16ACVR1B1.94537339
17MKNK11.93028133
18PLK41.88376161
19MAP4K21.85336017
20ZAK1.85333593
21WEE11.84043090
22CDC71.82417497
23BMPR1B1.80887646
24TSSK61.64046692
25MAPK131.55308524
26PLK31.50360633
27PNCK1.44182444
28STK391.32852872
29BUB11.32690220
30MARK11.30181173
31TTK1.26035722
32LATS11.25398614
33NEK11.24686178
34CSNK1G11.23650692
35PLK21.22174720
36MAP2K71.21625068
37PBK1.15100495
38CSNK1G21.13592191
39STK31.10245619
40CSNK1A1L1.09047485
41EIF2AK11.07343817
42TAF11.05230764
43AKT31.02837149
44DYRK30.99395263
45NLK0.99313691
46PAK30.96634166
47PLK10.96275069
48VRK10.95969335
49CSNK1G30.95821991
50OXSR10.94365300
51EPHA40.87961059
52MST40.87095259
53RPS6KA40.87075408
54CCNB10.84823253
55ATM0.81935685
56EIF2AK20.80274926
57ATR0.79985543
58SCYL20.79248248
59SGK20.74548523
60KSR10.73664942
61CAMKK20.72482192
62GRK10.70119709
63CHEK20.68463306
64CAMK1G0.67499437
65DYRK20.64950178
66STK240.64240360
67CDK30.61998665
68PRKCE0.61757266
69PINK10.59070632
70FGFR10.58907921
71OBSCN0.55911042
72ERBB40.53560004
73CHEK10.53403765
74INSRR0.51294895
75NEK20.51208956
76FGFR20.50623939
77ADRBK20.50088730
78DYRK1A0.49401330
79AURKB0.48553280
80CSNK1E0.47264564
81DMPK0.46866000
82PKN10.45693579
83TGFBR10.45144473
84TXK0.43707484
85PRKDC0.42593463
86MINK10.41893194
87SGK4940.41263924
88SGK2230.41263924
89CSNK1D0.39868460
90YES10.39164729
91CDK10.39130886
92FER0.38087467
93WNK40.37043728
94PRKACB0.35008758
95CAMK1D0.34168353
96SIK30.34114366
97BRSK10.34102200
98EPHA30.32008695
99PRKCG0.31993120
100CDK190.31635347

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.23249758
2Fanconi anemia pathway_Homo sapiens_hsa034603.33584435
3Homologous recombination_Homo sapiens_hsa034402.87925456
4Mismatch repair_Homo sapiens_hsa034302.74053177
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59610020
6Basal transcription factors_Homo sapiens_hsa030222.56748053
7Protein export_Homo sapiens_hsa030602.44183711
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42909198
9RNA degradation_Homo sapiens_hsa030182.37569416
10RNA transport_Homo sapiens_hsa030132.25711598
11Cell cycle_Homo sapiens_hsa041102.21855629
12Propanoate metabolism_Homo sapiens_hsa006402.06264996
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06234637
14Spliceosome_Homo sapiens_hsa030402.02338456
15Steroid biosynthesis_Homo sapiens_hsa001001.84404440
16mRNA surveillance pathway_Homo sapiens_hsa030151.74192117
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74003175
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73164010
19Nucleotide excision repair_Homo sapiens_hsa034201.72313149
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70469829
21DNA replication_Homo sapiens_hsa030301.69664189
22RNA polymerase_Homo sapiens_hsa030201.68338228
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65010059
24Circadian rhythm_Homo sapiens_hsa047101.64790544
25Nicotine addiction_Homo sapiens_hsa050331.57565711
26Selenocompound metabolism_Homo sapiens_hsa004501.42664921
27Oocyte meiosis_Homo sapiens_hsa041141.38640833
28Phototransduction_Homo sapiens_hsa047441.38083548
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33915355
30p53 signaling pathway_Homo sapiens_hsa041151.30077369
31Regulation of autophagy_Homo sapiens_hsa041401.23601625
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.21847316
33TGF-beta signaling pathway_Homo sapiens_hsa043501.18768026
34Butanoate metabolism_Homo sapiens_hsa006501.16791253
35Lysine degradation_Homo sapiens_hsa003101.11246156
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09641730
37One carbon pool by folate_Homo sapiens_hsa006701.05364584
38Hippo signaling pathway_Homo sapiens_hsa043901.05163006
39Taste transduction_Homo sapiens_hsa047421.04215356
40Hedgehog signaling pathway_Homo sapiens_hsa043401.02551166
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01539162
42Basal cell carcinoma_Homo sapiens_hsa052171.00861025
43Alcoholism_Homo sapiens_hsa050340.99478398
44Nitrogen metabolism_Homo sapiens_hsa009100.91247924
45Base excision repair_Homo sapiens_hsa034100.91113535
46Ether lipid metabolism_Homo sapiens_hsa005650.89483949
47Wnt signaling pathway_Homo sapiens_hsa043100.87312668
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87038093
49Purine metabolism_Homo sapiens_hsa002300.86343846
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82594725
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81715530
52MicroRNAs in cancer_Homo sapiens_hsa052060.81241967
53Colorectal cancer_Homo sapiens_hsa052100.79524158
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78260576
55Systemic lupus erythematosus_Homo sapiens_hsa053220.78119312
56Proteasome_Homo sapiens_hsa030500.77658688
57Glutamatergic synapse_Homo sapiens_hsa047240.70126492
58Pyrimidine metabolism_Homo sapiens_hsa002400.68050708
59Dopaminergic synapse_Homo sapiens_hsa047280.66921702
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65764828
61Axon guidance_Homo sapiens_hsa043600.62327568
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62030778
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.61920440
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61070525
65Adherens junction_Homo sapiens_hsa045200.59514266
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57731505
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57397226
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56599347
69Olfactory transduction_Homo sapiens_hsa047400.56476652
70Fatty acid biosynthesis_Homo sapiens_hsa000610.53091164
71Tight junction_Homo sapiens_hsa045300.51221648
72Morphine addiction_Homo sapiens_hsa050320.49065234
73FoxO signaling pathway_Homo sapiens_hsa040680.48853982
74GABAergic synapse_Homo sapiens_hsa047270.48355612
75Peroxisome_Homo sapiens_hsa041460.48332793
76Circadian entrainment_Homo sapiens_hsa047130.46336262
77Caffeine metabolism_Homo sapiens_hsa002320.46028065
78Linoleic acid metabolism_Homo sapiens_hsa005910.45005569
79Huntingtons disease_Homo sapiens_hsa050160.43151715
80Long-term depression_Homo sapiens_hsa047300.42657048
81Fatty acid metabolism_Homo sapiens_hsa012120.42132874
82Tryptophan metabolism_Homo sapiens_hsa003800.41912944
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39115787
84Amphetamine addiction_Homo sapiens_hsa050310.37315405
85Dorso-ventral axis formation_Homo sapiens_hsa043200.36375131
86Retinol metabolism_Homo sapiens_hsa008300.34507001
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.33936704
88Pyruvate metabolism_Homo sapiens_hsa006200.33495851
89Serotonergic synapse_Homo sapiens_hsa047260.33408326
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32056895
91Prostate cancer_Homo sapiens_hsa052150.29769630
92Metabolic pathways_Homo sapiens_hsa011000.28525156
93Melanoma_Homo sapiens_hsa052180.24513767
94Parkinsons disease_Homo sapiens_hsa050120.24223003
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.24096360
96Fatty acid degradation_Homo sapiens_hsa000710.23316292
97Sulfur metabolism_Homo sapiens_hsa009200.22939074
98Viral carcinogenesis_Homo sapiens_hsa052030.22101397
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21599437
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21549105

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