ZNF646

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.65913763
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58942494
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30404433
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30404433
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.30404433
6modulation by symbiont of host immune response (GO:0052553)4.30404433
7positive regulation by symbiont of host defense response (GO:0052509)4.30404433
8modulation by symbiont of host defense response (GO:0052031)4.30404433
9positive regulation of gamma-delta T cell activation (GO:0046645)4.18536362
10response to peptidoglycan (GO:0032494)4.04523611
11macrophage activation involved in immune response (GO:0002281)3.84894376
12negative regulation of cell killing (GO:0031342)3.81297031
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81297031
14regulation of interferon-beta biosynthetic process (GO:0045357)3.70310041
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67052769
16mannose metabolic process (GO:0006013)3.65032365
17response to muramyl dipeptide (GO:0032495)3.58910698
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50865952
19detection of molecule of bacterial origin (GO:0032490)3.44353409
20regulation of gamma-delta T cell activation (GO:0046643)3.41348992
21detection of other organism (GO:0098543)3.36990444
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27259468
23antigen processing and presentation of endogenous antigen (GO:0019883)3.26877042
24regulation of chromatin binding (GO:0035561)3.26639174
25regulation of T-helper 2 cell differentiation (GO:0045628)3.23614259
26detection of bacterium (GO:0016045)3.21252415
27histone H3-K36 demethylation (GO:0070544)3.18976543
28cellular extravasation (GO:0045123)3.18489201
29detection of external biotic stimulus (GO:0098581)3.15734242
30negative regulation of toll-like receptor signaling pathway (GO:0034122)3.15620236
31regulation of gamma-delta T cell differentiation (GO:0045586)3.09143019
32germinal center formation (GO:0002467)3.06282743
33regulation of ARF GTPase activity (GO:0032312)3.05563127
34positive thymic T cell selection (GO:0045059)3.04451311
35B cell receptor signaling pathway (GO:0050853)2.96794749
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94878583
37regulation of leukocyte degranulation (GO:0043300)2.94698538
38regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90396699
39intracellular estrogen receptor signaling pathway (GO:0030520)2.89790048
40response to laminar fluid shear stress (GO:0034616)2.87965799
41regulation of mast cell degranulation (GO:0043304)2.87708977
42leukocyte aggregation (GO:0070486)2.86850788
43regulation of NFAT protein import into nucleus (GO:0051532)2.85001180
44negative regulation of interleukin-12 production (GO:0032695)2.84374126
45NIK/NF-kappaB signaling (GO:0038061)2.83012934
46regulation of B cell receptor signaling pathway (GO:0050855)2.82234925
47negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.81607918
48regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81083358
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.79389877
50modulation by symbiont of host cellular process (GO:0044068)2.79038120
51detection of biotic stimulus (GO:0009595)2.77637152
52modulation by virus of host process (GO:0019054)2.77134369
53thymic T cell selection (GO:0045061)2.77009345
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76901960
55response to host immune response (GO:0052572)2.76901960
56regulation of histone H3-K27 methylation (GO:0061085)2.75328203
57adenosine receptor signaling pathway (GO:0001973)2.75000781
58negative regulation of granulocyte differentiation (GO:0030853)2.74229465
59response to host (GO:0075136)2.72746515
60response to host defenses (GO:0052200)2.72746515
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72746515
62lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72127986
63neutrophil activation involved in immune response (GO:0002283)2.69491039
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68227910
65G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.67230531
66cellular response to virus (GO:0098586)2.66436367
67myeloid cell activation involved in immune response (GO:0002275)2.66218017
68positive regulation of histone deacetylation (GO:0031065)2.63897766
69response to type I interferon (GO:0034340)2.60856423
70chromosome condensation (GO:0030261)2.59956649
71negative regulation of viral release from host cell (GO:1902187)2.59556518
72chromatin silencing (GO:0006342)2.57901287
73cellular response to type I interferon (GO:0071357)2.55915393
74type I interferon signaling pathway (GO:0060337)2.55915393
75embryonic process involved in female pregnancy (GO:0060136)2.55620434
76negative regulation of interleukin-8 production (GO:0032717)2.55579167
77regulation of mast cell activation involved in immune response (GO:0033006)2.54238877
78apoptotic process involved in morphogenesis (GO:0060561)2.53161743
79negative regulation of histone methylation (GO:0031061)2.52256106
80positive regulation of interferon-alpha production (GO:0032727)2.52151896
81respiratory burst (GO:0045730)2.51631290
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49989829
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49276974
84G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.47562531
85protein localization to endosome (GO:0036010)2.46213705
86T cell selection (GO:0045058)2.45397603
87macrophage activation (GO:0042116)2.43172781
88histone lysine demethylation (GO:0070076)2.42102284
89immunoglobulin mediated immune response (GO:0016064)2.40065056
90CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.38803640
91positive regulation of myotube differentiation (GO:0010831)2.36849032
92positive T cell selection (GO:0043368)2.36426213
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35886216
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.35733583
95regulation of necroptotic process (GO:0060544)2.35341937
96histone demethylation (GO:0016577)2.35275658
97pinocytosis (GO:0006907)2.35179792
98negative regulation of gene expression, epigenetic (GO:0045814)2.34556189
99histone H4 deacetylation (GO:0070933)2.34327797
100negative regulation of leukocyte mediated immunity (GO:0002704)2.34236082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.91671790
2MYC_22102868_ChIP-Seq_BL_Human3.37339630
3* LXR_22292898_ChIP-Seq_THP-1_Human2.84308586
4* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73762335
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66020450
6* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.60595817
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55131600
8TCF7_22412390_ChIP-Seq_EML_Mouse2.54835635
9VDR_24763502_ChIP-Seq_THP-1_Human2.51850416
10* KDM2B_26808549_Chip-Seq_DND41_Human2.43389681
11MAF_26560356_Chip-Seq_TH1_Human2.33026750
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.28627768
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26029561
14MAF_26560356_Chip-Seq_TH2_Human2.09732736
15UTX_26944678_Chip-Seq_JUKART_Human2.03826637
16* RACK7_27058665_Chip-Seq_MCF-7_Human2.00964198
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00579366
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98531041
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98179552
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95236722
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.93805996
22P68_20966046_ChIP-Seq_HELA_Human1.92776255
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90813523
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89114894
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.84932757
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73041285
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.69103346
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68766435
29KDM2B_26808549_Chip-Seq_K562_Human1.68293751
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66613116
31BCOR_27268052_Chip-Seq_Bcells_Human1.62913444
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62896097
33SMC4_20622854_ChIP-Seq_HELA_Human1.61596557
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.61365039
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54142553
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53891281
37* SA1_27219007_Chip-Seq_ERYTHROID_Human1.53039098
38SCL_19346495_ChIP-Seq_HPC-7_Human1.52808139
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52088353
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.51716038
41BCL6_27268052_Chip-Seq_Bcells_Human1.50644214
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47193232
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45191115
44* NCOR1_26117541_ChIP-Seq_K562_Human1.43942399
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42326062
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.41993916
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41262198
48* SPI1_23127762_ChIP-Seq_K562_Human1.37786628
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37703050
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.37171865
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.35057133
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33456891
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.32399961
54* CREB1_26743006_Chip-Seq_LNCaP_Human1.30836955
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.30427127
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29839724
57GATA1_19941826_ChIP-Seq_K562_Human1.27464327
58MYB_26560356_Chip-Seq_TH1_Human1.26242895
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25673639
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25228321
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.23974573
62TP53_22127205_ChIP-Seq_IMR90_Human1.23119846
63PHF8_20622854_ChIP-Seq_HELA_Human1.22748194
64E2F1_20622854_ChIP-Seq_HELA_Human1.21816006
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21696223
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21283113
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21027921
68* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20512902
69* SPI1_23547873_ChIP-Seq_NB4_Human1.20357353
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.19658521
71* RUNX1_27514584_Chip-Seq_MCF-7_Human1.19636943
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19628770
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19164439
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18745494
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18265283
76CTCF_21964334_Chip-Seq_Bcells_Human1.17678803
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17490451
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16514162
79E2F7_22180533_ChIP-Seq_HELA_Human1.16211485
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14545524
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13607566
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13461596
83CIITA_25753668_ChIP-Seq_RAJI_Human1.12503638
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12158054
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11200609
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10951711
87CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10780560
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09517453
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09061798
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08741982
91ATF3_27146783_Chip-Seq_COLON_Human1.08392006
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07022024
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05054632
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.04931151
95CTCF_27219007_Chip-Seq_Bcells_Human1.04758686
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03836780
97* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02772802
98* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02672745
99RARA_24833708_ChIP-Seq_LIVER_Mouse1.01437822
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01250423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.74907443
2MP0003436_decreased_susceptibility_to3.33620671
3MP0003705_abnormal_hypodermis_morpholog3.18796164
4MP0005451_abnormal_body_composition2.95022487
5MP0009278_abnormal_bone_marrow2.92650535
6MP0005076_abnormal_cell_differentiation2.73743153
7MP0003172_abnormal_lysosome_physiology2.37733100
8MP0001835_abnormal_antigen_presentation2.25504689
9MP0005058_abnormal_lysosome_morphology2.20979836
10MP0000685_abnormal_immune_system2.19376921
11MP0002419_abnormal_innate_immunity2.11383048
12MP0004381_abnormal_hair_follicle2.04432103
13MP0003300_gastrointestinal_ulcer2.01134021
14MP0008260_abnormal_autophagy2.00614061
15MP0005409_darkened_coat_color1.98969365
16MP0003763_abnormal_thymus_physiology1.97918838
17MP0005025_abnormal_response_to1.95045030
18MP0001800_abnormal_humoral_immune1.92639205
19MP0005000_abnormal_immune_tolerance1.89980608
20MP0004947_skin_inflammation1.88429546
21MP0003724_increased_susceptibility_to1.88297979
22MP0003453_abnormal_keratinocyte_physiol1.86438878
23MP0003091_abnormal_cell_migration1.79836379
24MP0005387_immune_system_phenotype1.79566214
25MP0001790_abnormal_immune_system1.79566214
26MP0002396_abnormal_hematopoietic_system1.78359055
27MP0002723_abnormal_immune_serum1.77573265
28MP0002452_abnormal_antigen_presenting1.76017398
29MP0005410_abnormal_fertilization1.75424200
30MP0001348_abnormal_lacrimal_gland1.74815820
31MP0009840_abnormal_foam_cell1.72420950
32MP0002420_abnormal_adaptive_immunity1.69570220
33MP0001819_abnormal_immune_cell1.68374868
34MP0002398_abnormal_bone_marrow1.65347670
35MP0009333_abnormal_splenocyte_physiolog1.64677153
36MP0005397_hematopoietic_system_phenotyp1.56756801
37MP0001545_abnormal_hematopoietic_system1.56756801
38MP0004808_abnormal_hematopoietic_stem1.56092263
39MP0005083_abnormal_biliary_tract1.50415315
40MP0002405_respiratory_system_inflammati1.47651406
41MP0005671_abnormal_response_to1.46602843
42MP0000716_abnormal_immune_system1.43263960
43MP0003191_abnormal_cellular_cholesterol1.42071672
44MP0000703_abnormal_thymus_morphology1.39403224
45MP0001849_ear_inflammation1.37677678
46MP0002722_abnormal_immune_system1.37599309
47MP0005310_abnormal_salivary_gland1.37538943
48MP0000858_altered_metastatic_potential1.37446541
49MP0009785_altered_susceptibility_to1.37142311
50MP0001533_abnormal_skeleton_physiology1.34520276
51MP0004510_myositis1.33443094
52MP0002998_abnormal_bone_remodeling1.29736804
53MP0002429_abnormal_blood_cell1.29501569
54MP0003828_pulmonary_edema1.27651358
55MP0001873_stomach_inflammation1.24914845
56MP0000689_abnormal_spleen_morphology1.23737448
57MP0010155_abnormal_intestine_physiology1.22591146
58MP0004185_abnormal_adipocyte_glucose1.21645519
59MP0002132_abnormal_respiratory_system1.16819769
60MP0005464_abnormal_platelet_physiology1.16494672
61MP0006082_CNS_inflammation1.13893069
62MP0003566_abnormal_cell_adhesion1.10994109
63MP0004858_abnormal_nervous_system1.09865478
64MP0002148_abnormal_hypersensitivity_rea1.09139359
65MP0003656_abnormal_erythrocyte_physiolo1.08582177
66MP0001845_abnormal_inflammatory_respons1.04869903
67MP0000015_abnormal_ear_pigmentation1.04619563
68MP0004233_abnormal_muscle_weight1.02208710
69MP0003448_altered_tumor_morphology1.01857768
70MP0000490_abnormal_crypts_of1.01607604
71MP0003111_abnormal_nucleus_morphology1.01159303
72MP0005377_hearing/vestibular/ear_phenot1.00921545
73MP0003878_abnormal_ear_physiology1.00921545
74MP0000003_abnormal_adipose_tissue1.00742216
75MP0005375_adipose_tissue_phenotype0.99677765
76MP0000678_abnormal_parathyroid_gland0.99143251
77MP0005666_abnormal_adipose_tissue0.99040647
78MP0005174_abnormal_tail_pigmentation0.98305493
79MP0008469_abnormal_protein_level0.93254348
80MP0004130_abnormal_muscle_cell0.86942994
81MP0002249_abnormal_larynx_morphology0.85956141
82MP0005171_absent_coat_pigmentation0.84908817
83MP0005621_abnormal_cell_physiology0.83025172
84MP0009931_abnormal_skin_appearance0.82638475
85MP0001986_abnormal_taste_sensitivity0.82069545
86MP0002166_altered_tumor_susceptibility0.81580530
87MP0005423_abnormal_somatic_nervous0.80246428
88MP0002933_joint_inflammation0.79125988
89MP0010307_abnormal_tumor_latency0.78950935
90MP0004264_abnormal_extraembryonic_tissu0.78546438
91MP0002254_reproductive_system_inflammat0.77182464
92MP0000750_abnormal_muscle_regeneration0.74788826
93MP0003183_abnormal_peptide_metabolism0.74640576
94MP0003329_amyloid_beta_deposits0.74026825
95MP0000313_abnormal_cell_death0.73305179
96MP0003077_abnormal_cell_cycle0.73281925
97MP0002019_abnormal_tumor_incidence0.72092261
98MP0002089_abnormal_postnatal_growth/wei0.70357380
99MP0000604_amyloidosis0.69582389
100MP0008057_abnormal_DNA_replication0.68678487

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.02654125
2Thin bony cortex (HP:0002753)3.58892958
3Recurrent bacterial skin infections (HP:0005406)3.40247795
4Recurrent abscess formation (HP:0002722)3.40170243
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.34581596
6Abnormality of macrophages (HP:0004311)3.29701655
7Abnormality of the fingertips (HP:0001211)3.25468090
8Hemorrhage of the eye (HP:0011885)3.09440765
9Cellulitis (HP:0100658)3.04643279
10Gastrointestinal infarctions (HP:0005244)2.95325233
11Colitis (HP:0002583)2.86843872
12Ulnar bowing (HP:0003031)2.85093353
13Gingivitis (HP:0000230)2.76872142
14Increased IgE level (HP:0003212)2.59333067
15Myositis (HP:0100614)2.56954447
16Recurrent fungal infections (HP:0002841)2.54627626
17Orchitis (HP:0100796)2.44088805
18Chronic obstructive pulmonary disease (HP:0006510)2.39198856
19Obstructive lung disease (HP:0006536)2.39198856
20Mediastinal lymphadenopathy (HP:0100721)2.37814312
21Recurrent gram-negative bacterial infections (HP:0005420)2.36839333
22Intestinal fistula (HP:0100819)2.35952734
23Recurrent skin infections (HP:0001581)2.35105900
24Gastrointestinal inflammation (HP:0004386)2.34545073
25Broad face (HP:0000283)2.33569518
26Meningitis (HP:0001287)2.32589846
27Recurrent cutaneous fungal infections (HP:0011370)2.32004094
28Chronic mucocutaneous candidiasis (HP:0002728)2.32004094
29Hyperacusis (HP:0010780)2.22706726
30Spontaneous hematomas (HP:0007420)2.21501701
31Asymmetric septal hypertrophy (HP:0001670)2.21460284
32Slow saccadic eye movements (HP:0000514)2.19106214
33Inflammation of the large intestine (HP:0002037)2.18906398
34Recurrent viral infections (HP:0004429)2.17724729
35Annular pancreas (HP:0001734)2.14221435
36Hypochromic anemia (HP:0001931)2.11086052
37Poikiloderma (HP:0001029)2.09310058
38Turricephaly (HP:0000262)2.07533862
39Optic neuritis (HP:0100653)2.05014668
40Retrobulbar optic neuritis (HP:0100654)2.05014668
41Nasal polyposis (HP:0100582)2.04708951
42Increased cerebral lipofuscin (HP:0011813)2.00978183
43Dislocated radial head (HP:0003083)2.00343294
44Emphysema (HP:0002097)1.95191771
45Abnormality of the thoracic spine (HP:0100711)1.95031061
46Epistaxis (HP:0000421)1.94447055
47Cerebral aneurysm (HP:0004944)1.93817837
48Abnormality of the nasal mucosa (HP:0000433)1.93715883
49Segmental peripheral demyelination/remyelination (HP:0003481)1.91099428
50Hypertriglyceridemia (HP:0002155)1.91067433
51Obstructive sleep apnea (HP:0002870)1.90674313
52Long palpebral fissure (HP:0000637)1.90196799
53Pustule (HP:0200039)1.87734814
54Chest pain (HP:0100749)1.84586759
55Long eyelashes (HP:0000527)1.83892063
56Vaginal fistula (HP:0004320)1.83610883
57Malnutrition (HP:0004395)1.81390875
58Thin ribs (HP:0000883)1.80778850
59Abnormality of the radial head (HP:0003995)1.80562664
60Abnormal delayed hypersensitivity skin test (HP:0002963)1.80142863
61Easy fatigability (HP:0003388)1.79608345
62Metaphyseal cupping (HP:0003021)1.79413285
63Joint hemorrhage (HP:0005261)1.78809293
64Spinal cord lesions (HP:0100561)1.78640383
65Syringomyelia (HP:0003396)1.78640383
66Hypertensive crisis (HP:0100735)1.75015614
67Prolonged bleeding time (HP:0003010)1.74727511
68Delayed epiphyseal ossification (HP:0002663)1.74576816
69Thoracic kyphosis (HP:0002942)1.72539693
70Abnormality of the distal phalanx of the thumb (HP:0009617)1.72391866
71Arterial thrombosis (HP:0004420)1.72072054
72Viral hepatitis (HP:0006562)1.71947967
73Cheilitis (HP:0100825)1.70724999
74Osteomyelitis (HP:0002754)1.70211964
75Testicular atrophy (HP:0000029)1.69891803
76Widely patent fontanelles and sutures (HP:0004492)1.68952942
77Persistence of primary teeth (HP:0006335)1.68924956
78Increased neuronal autofluorescent lipopigment (HP:0002074)1.67942640
79Abnormality of the columella (HP:0009929)1.67787305
80Vasculitis (HP:0002633)1.65293091
81Disproportionate tall stature (HP:0001519)1.64909917
82Dysostosis multiplex (HP:0000943)1.63986213
83Rectal fistula (HP:0100590)1.62422203
84Rectovaginal fistula (HP:0000143)1.62422203
85Anteriorly placed anus (HP:0001545)1.62169261
86Supernumerary nipples (HP:0002558)1.62144331
87Mucopolysacchariduria (HP:0008155)1.61983521
88Urinary glycosaminoglycan excretion (HP:0003541)1.61983521
89Germ cell neoplasia (HP:0100728)1.61913190
90Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61617019
91Abnormality of polysaccharide metabolism (HP:0011012)1.61617019
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61617019
93Loss of speech (HP:0002371)1.61410500
94Subacute progressive viral hepatitis (HP:0006572)1.57682864
95Squamous cell carcinoma (HP:0002860)1.57560571
96Abnormality of the costochondral junction (HP:0000919)1.56402333
97Myocardial infarction (HP:0001658)1.55290391
98Progressive external ophthalmoplegia (HP:0000590)1.53238195
99Distal lower limb amyotrophy (HP:0008944)1.52297409
100Facial hemangioma (HP:0000329)1.52215843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.98885748
2PRPF4B3.23160705
3CDK123.19832225
4ERN13.09877506
5SMG12.75424607
6RIPK42.60790464
7MAP2K32.44333722
8ICK2.39733917
9MAP4K12.38171240
10SIK12.32976786
11BLK2.24848027
12EEF2K2.06687828
13MAP3K102.01337314
14SIK21.90379349
15IRAK31.86852969
16RIPK11.67901732
17IRAK41.64461539
18FGFR41.50436558
19MAPK151.50295647
20CSK1.44171924
21MARK21.42404641
22TYK21.42148654
23ZAP701.40397629
24BRD41.39326060
25MAP3K131.36052494
26MAP3K111.33683150
27MAP3K31.26836850
28PDPK11.25391070
29GRK61.22920728
30KSR21.21315440
31PKN21.21075178
32MAP3K11.18461827
33TAOK11.16787095
34CAMK1D1.16383465
35PRKD21.14213921
36MAP3K141.10991002
37MTOR1.09614298
38CDC42BPA1.07055152
39TBK11.06673235
40CDK41.06378248
41TAOK21.02529599
42BTK1.02318836
43EPHB10.99585068
44TNK20.99360633
45TTN0.97334338
46DYRK1B0.97243954
47CAMK1G0.95425769
48TESK20.95139926
49IRAK20.94392576
50JAK30.93656894
51RPS6KA20.92517208
52RPS6KC10.91986530
53RPS6KL10.91986530
54HCK0.91518806
55PDK10.87944673
56DDR20.86374879
57PTK60.85712577
58MAPK110.85511709
59IKBKE0.83224388
60WNK10.79207258
61FES0.78071503
62HIPK20.74941176
63CSF1R0.73237745
64RPS6KA60.72573964
65SIK30.72568629
66SYK0.71572480
67FGR0.68797347
68MAP3K70.67539335
69CDK60.67034614
70MAPK120.65897580
71STK380.62295379
72FGFR30.61704234
73JAK20.61475906
74MAP3K80.58397920
75BMX0.57975792
76RET0.57167884
77SGK30.57123968
78CDK70.56068404
79IKBKB0.55336587
80LYN0.55323806
81CHUK0.54097528
82TYRO30.53879117
83JAK10.52850772
84MELK0.52483582
85RPS6KA10.52222939
86MAP2K20.51489926
87PDGFRA0.50656370
88MAPK70.47004973
89TLK10.45433534
90PRKD30.45328570
91MAP3K60.45050937
92LCK0.44541860
93MATK0.41666283
94KIT0.39669688
95PIM10.39035235
96MARK30.36619315
97BRAF0.35404596
98RAF10.35026437
99NEK60.34221721
100PIM20.34168715

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.23325614
2Acute myeloid leukemia_Homo sapiens_hsa052212.19357894
3Osteoclast differentiation_Homo sapiens_hsa043802.13398794
4Other glycan degradation_Homo sapiens_hsa005112.09830890
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95382167
6Non-small cell lung cancer_Homo sapiens_hsa052231.83911253
7Leishmaniasis_Homo sapiens_hsa051401.81779474
8Chronic myeloid leukemia_Homo sapiens_hsa052201.81119841
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78944459
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69877848
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63272439
12Notch signaling pathway_Homo sapiens_hsa043301.61388889
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59890816
14VEGF signaling pathway_Homo sapiens_hsa043701.56266845
15Influenza A_Homo sapiens_hsa051641.47293710
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.45365323
17Pancreatic cancer_Homo sapiens_hsa052121.43713893
18mTOR signaling pathway_Homo sapiens_hsa041501.38656759
19Tuberculosis_Homo sapiens_hsa051521.38640237
20Hepatitis B_Homo sapiens_hsa051611.36804572
21Toxoplasmosis_Homo sapiens_hsa051451.35862479
22Bladder cancer_Homo sapiens_hsa052191.35613681
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.32496689
24Measles_Homo sapiens_hsa051621.29143696
25TNF signaling pathway_Homo sapiens_hsa046681.28056617
26Endometrial cancer_Homo sapiens_hsa052131.27575293
27T cell receptor signaling pathway_Homo sapiens_hsa046601.26954784
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.26798827
29Staphylococcus aureus infection_Homo sapiens_hsa051501.25413249
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19197266
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18235916
32Herpes simplex infection_Homo sapiens_hsa051681.17343401
33Hepatitis C_Homo sapiens_hsa051601.16694225
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13595972
35Apoptosis_Homo sapiens_hsa042101.12557019
36Viral carcinogenesis_Homo sapiens_hsa052031.11736124
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10163444
38Renal cell carcinoma_Homo sapiens_hsa052111.10136596
39Inositol phosphate metabolism_Homo sapiens_hsa005621.10004392
40Malaria_Homo sapiens_hsa051441.07753590
41Chemokine signaling pathway_Homo sapiens_hsa040621.07629654
42Prolactin signaling pathway_Homo sapiens_hsa049171.07406049
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.06632280
44Primary immunodeficiency_Homo sapiens_hsa053401.05006086
45Allograft rejection_Homo sapiens_hsa053301.04380849
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.03221300
47Graft-versus-host disease_Homo sapiens_hsa053321.02223423
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01471708
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00492800
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99487993
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99456181
52Prostate cancer_Homo sapiens_hsa052150.98422510
53Viral myocarditis_Homo sapiens_hsa054160.95340419
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93717756
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.93705281
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.92002225
57Autoimmune thyroid disease_Homo sapiens_hsa053200.91501826
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.91272835
59Insulin resistance_Homo sapiens_hsa049310.91216272
60Lysosome_Homo sapiens_hsa041420.91158607
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90910688
62ErbB signaling pathway_Homo sapiens_hsa040120.90213976
63Endocytosis_Homo sapiens_hsa041440.89861717
64Colorectal cancer_Homo sapiens_hsa052100.89523472
65Fructose and mannose metabolism_Homo sapiens_hsa000510.86949315
66FoxO signaling pathway_Homo sapiens_hsa040680.86787033
67Glioma_Homo sapiens_hsa052140.86776147
68Thyroid cancer_Homo sapiens_hsa052160.86463671
69HTLV-I infection_Homo sapiens_hsa051660.85481678
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84743611
71Insulin signaling pathway_Homo sapiens_hsa049100.84575292
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.81483103
73Antigen processing and presentation_Homo sapiens_hsa046120.79840312
74Hematopoietic cell lineage_Homo sapiens_hsa046400.79507855
75Small cell lung cancer_Homo sapiens_hsa052220.79307208
76MicroRNAs in cancer_Homo sapiens_hsa052060.79089830
77Type II diabetes mellitus_Homo sapiens_hsa049300.78409152
78Choline metabolism in cancer_Homo sapiens_hsa052310.77743376
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77296919
80Platelet activation_Homo sapiens_hsa046110.76544926
81Epstein-Barr virus infection_Homo sapiens_hsa051690.74888871
82GnRH signaling pathway_Homo sapiens_hsa049120.71807985
83Legionellosis_Homo sapiens_hsa051340.71129050
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70091658
85HIF-1 signaling pathway_Homo sapiens_hsa040660.69054453
86Lysine degradation_Homo sapiens_hsa003100.68738213
87Sulfur relay system_Homo sapiens_hsa041220.68712042
88Estrogen signaling pathway_Homo sapiens_hsa049150.68140442
89Dorso-ventral axis formation_Homo sapiens_hsa043200.66113285
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66071577
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63787888
92Systemic lupus erythematosus_Homo sapiens_hsa053220.63604283
93MAPK signaling pathway_Homo sapiens_hsa040100.62490515
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60927421
95Salmonella infection_Homo sapiens_hsa051320.60428061
96Pertussis_Homo sapiens_hsa051330.59838372
97Phagosome_Homo sapiens_hsa041450.58968691
98Amoebiasis_Homo sapiens_hsa051460.58071890
99Prion diseases_Homo sapiens_hsa050200.57554283
100Proteoglycans in cancer_Homo sapiens_hsa052050.56157495

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