ZNF649

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.25309792
2regulation of posttranscriptional gene silencing (GO:0060147)4.25309792
3regulation of gene silencing by miRNA (GO:0060964)4.25309792
4pre-miRNA processing (GO:0031054)4.16158857
5protein localization to kinetochore (GO:0034501)4.15725528
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.05855792
7regulation of translation, ncRNA-mediated (GO:0045974)4.05855792
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.05855792
9DNA double-strand break processing (GO:0000729)4.03868955
10regulation of helicase activity (GO:0051095)3.99363915
11establishment of integrated proviral latency (GO:0075713)3.85162404
12chromatin remodeling at centromere (GO:0031055)3.83575165
13somatic hypermutation of immunoglobulin genes (GO:0016446)3.80721044
14somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80721044
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.74055519
16presynaptic membrane assembly (GO:0097105)3.68358185
17CENP-A containing nucleosome assembly (GO:0034080)3.65077354
18regulation of mitotic spindle checkpoint (GO:1903504)3.59938919
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59938919
20L-serine metabolic process (GO:0006563)3.51616254
21regulation of histone H3-K9 methylation (GO:0051570)3.50318480
22histone exchange (GO:0043486)3.45504565
23negative regulation of DNA recombination (GO:0045910)3.44497939
24DNA damage response, detection of DNA damage (GO:0042769)3.40292462
25spindle checkpoint (GO:0031577)3.40138642
26mitotic metaphase plate congression (GO:0007080)3.38553235
27negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37095140
28negative regulation of mitotic sister chromatid separation (GO:2000816)3.37095140
29negative regulation of sister chromatid segregation (GO:0033046)3.37095140
30negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37095140
31negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37095140
32mitotic spindle checkpoint (GO:0071174)3.35548714
33DNA replication-dependent nucleosome organization (GO:0034723)3.27726840
34DNA replication-dependent nucleosome assembly (GO:0006335)3.27726840
35negative regulation of chromosome segregation (GO:0051985)3.27698208
36metaphase plate congression (GO:0051310)3.19331996
37IMP biosynthetic process (GO:0006188)3.18809257
38DNA replication-independent nucleosome organization (GO:0034724)3.18434565
39DNA replication-independent nucleosome assembly (GO:0006336)3.18434565
40protein localization to chromosome, centromeric region (GO:0071459)3.14821152
41replication fork processing (GO:0031297)3.13413333
42nuclear pore complex assembly (GO:0051292)3.09659795
43regulation of centriole replication (GO:0046599)3.06737487
44non-recombinational repair (GO:0000726)3.06533537
45double-strand break repair via nonhomologous end joining (GO:0006303)3.06533537
46regulation of meiosis I (GO:0060631)3.05075216
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.02756551
48regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01924794
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01924794
50mitotic spindle assembly checkpoint (GO:0007094)3.00767776
51regulation of mitotic sister chromatid separation (GO:0010965)2.99831212
52regulation of mitotic sister chromatid segregation (GO:0033047)2.99831212
53regulation of sister chromatid segregation (GO:0033045)2.99831212
54pyrimidine nucleobase catabolic process (GO:0006208)2.98754541
55lysine metabolic process (GO:0006553)2.98635894
56lysine catabolic process (GO:0006554)2.98635894
57spindle assembly checkpoint (GO:0071173)2.95385129
58presynaptic membrane organization (GO:0097090)2.93645185
59telomere maintenance via telomerase (GO:0007004)2.92771589
60nuclear pore organization (GO:0006999)2.90605852
61DNA ligation (GO:0006266)2.87897037
62establishment of viral latency (GO:0019043)2.86730708
63negative regulation of histone methylation (GO:0031061)2.84621645
64single strand break repair (GO:0000012)2.83633935
65mitotic sister chromatid cohesion (GO:0007064)2.83423890
66regulation of chromosome segregation (GO:0051983)2.80666971
67regulation of telomere maintenance via telomerase (GO:0032210)2.80471690
68IMP metabolic process (GO:0046040)2.80280646
69DNA strand elongation involved in DNA replication (GO:0006271)2.79505378
70regulation of gene silencing (GO:0060968)2.77544618
71purine nucleobase biosynthetic process (GO:0009113)2.77464941
72negative regulation of mitosis (GO:0045839)2.77259878
73regulation of DNA endoreduplication (GO:0032875)2.76746432
74ATP-dependent chromatin remodeling (GO:0043044)2.75898335
75histone H2A acetylation (GO:0043968)2.75863679
76DNA strand renaturation (GO:0000733)2.74394746
77response to X-ray (GO:0010165)2.73871400
78regulation of chromatin silencing (GO:0031935)2.73861769
79ribosome assembly (GO:0042255)2.71088798
80cell fate commitment involved in formation of primary germ layer (GO:0060795)2.69672888
81DNA replication checkpoint (GO:0000076)2.69050342
82regulation of DNA methylation (GO:0044030)2.68725291
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66708963
84retinal cone cell development (GO:0046549)2.66439396
85ncRNA catabolic process (GO:0034661)2.64613793
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64324745
87DNA catabolic process, exonucleolytic (GO:0000738)2.63506361
88centriole replication (GO:0007099)2.62912070
89cullin deneddylation (GO:0010388)2.62579129
90mitotic nuclear envelope disassembly (GO:0007077)2.60614828
91DNA strand elongation (GO:0022616)2.59565402
92DNA topological change (GO:0006265)2.59081326
93lung-associated mesenchyme development (GO:0060484)2.55209188
94kinetochore assembly (GO:0051382)2.54820584
95protein complex localization (GO:0031503)2.54359992
96negative regulation of nuclear division (GO:0051784)2.54314055
97prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53248227
98postreplication repair (GO:0006301)2.52927570
99histone mRNA metabolic process (GO:0008334)2.52390868
100kinetochore organization (GO:0051383)2.52335076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.98069730
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.73554797
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96875094
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91759682
5ZNF274_21170338_ChIP-Seq_K562_Hela2.89268162
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66043638
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62346980
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62292519
9EWS_26573619_Chip-Seq_HEK293_Human2.41864064
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39114132
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.37458179
12FUS_26573619_Chip-Seq_HEK293_Human2.36084261
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29444830
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29380264
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.27967454
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25894068
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10838698
18ELK1_19687146_ChIP-ChIP_HELA_Human2.08615920
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05196615
20GBX2_23144817_ChIP-Seq_PC3_Human2.04901076
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03174154
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00066003
23P300_19829295_ChIP-Seq_ESCs_Human1.96439494
24VDR_22108803_ChIP-Seq_LS180_Human1.96159127
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.88303206
26TAF15_26573619_Chip-Seq_HEK293_Human1.83633715
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82346485
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.82024284
29SOX2_16153702_ChIP-ChIP_HESCs_Human1.81884259
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77170012
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71378847
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71306030
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.68597066
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68464968
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64320490
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63403019
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63403019
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63403019
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.62903811
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62826356
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.51505644
42MYC_18940864_ChIP-ChIP_HL60_Human1.51066009
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.50623641
44VDR_23849224_ChIP-Seq_CD4+_Human1.48628181
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47843991
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.47828220
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46307763
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45840749
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45810328
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.45671686
51AR_21909140_ChIP-Seq_LNCAP_Human1.41786809
52IRF1_19129219_ChIP-ChIP_H3396_Human1.40871431
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40511153
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38774078
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36379038
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34409210
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34409210
58FOXP3_21729870_ChIP-Seq_TREG_Human1.31936110
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31497535
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31334812
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31158123
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.25034017
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.23718168
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23705692
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23479419
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21788501
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19902512
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19634013
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14925360
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14582460
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14459468
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14427689
73CBP_20019798_ChIP-Seq_JUKART_Human1.14427689
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14254797
75SMAD4_21799915_ChIP-Seq_A2780_Human1.13347848
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10670445
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10447879
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09643533
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09570747
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.09439728
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09239296
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02894503
83STAT3_23295773_ChIP-Seq_U87_Human1.02137159
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01549121
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01435962
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00647396
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99817082
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99372700
89TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99168930
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98418561
91TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97817439
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97701909
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96664760
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96377506
95SOX9_26525672_Chip-Seq_HEART_Mouse0.95205942
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.94714634
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94382521
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92364346
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92193629
100TCF4_23295773_ChIP-Seq_U87_Human0.91847577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.95624077
2MP0008057_abnormal_DNA_replication3.83412067
3MP0008058_abnormal_DNA_repair3.41673870
4MP0003693_abnormal_embryo_hatching2.92449558
5MP0010094_abnormal_chromosome_stability2.92014239
6MP0003941_abnormal_skin_development2.70067401
7MP0003718_maternal_effect2.55751481
8MP0004957_abnormal_blastocyst_morpholog2.54003061
9MP0006292_abnormal_olfactory_placode2.52249143
10MP0003890_abnormal_embryonic-extraembry2.48234467
11MP0003111_abnormal_nucleus_morphology2.41481445
12MP0003077_abnormal_cell_cycle2.12376349
13MP0002254_reproductive_system_inflammat2.05543415
14MP0001293_anophthalmia2.05066482
15MP0003787_abnormal_imprinting1.99780819
16MP0003136_yellow_coat_color1.99711214
17MP0008932_abnormal_embryonic_tissue1.87047746
18MP0001529_abnormal_vocalization1.84381090
19MP0003937_abnormal_limbs/digits/tail_de1.78863433
20MP0000537_abnormal_urethra_morphology1.74179459
21MP0003121_genomic_imprinting1.72745571
22MP0002102_abnormal_ear_morphology1.71039073
23MP0009672_abnormal_birth_weight1.66123708
24MP0008007_abnormal_cellular_replicative1.63742690
25MP0003567_abnormal_fetal_cardiomyocyte1.62667023
26MP0008789_abnormal_olfactory_epithelium1.59554345
27MP0001984_abnormal_olfaction1.57225041
28MP0002234_abnormal_pharynx_morphology1.56514957
29MP0004133_heterotaxia1.54790733
30MP0005394_taste/olfaction_phenotype1.48949029
31MP0005499_abnormal_olfactory_system1.48949029
32MP0003119_abnormal_digestive_system1.45640426
33MP0002736_abnormal_nociception_after1.42280259
34MP0001188_hyperpigmentation1.41794659
35MP0005367_renal/urinary_system_phenotyp1.40838411
36MP0000516_abnormal_urinary_system1.40838411
37MP0002751_abnormal_autonomic_nervous1.39717209
38MP0003880_abnormal_central_pattern1.36168545
39MP0002233_abnormal_nose_morphology1.35143525
40MP0002938_white_spotting1.34047221
41MP0003122_maternal_imprinting1.33266029
42MP0002084_abnormal_developmental_patter1.33141100
43MP0009703_decreased_birth_body1.32260624
44MP0006276_abnormal_autonomic_nervous1.29139610
45MP0002085_abnormal_embryonic_tissue1.27123006
46MP0002697_abnormal_eye_size1.25226574
47MP0008995_early_reproductive_senescence1.23327464
48MP0000049_abnormal_middle_ear1.21368440
49MP0001286_abnormal_eye_development1.21345400
50MP0000631_abnormal_neuroendocrine_gland1.18982608
51MP0001730_embryonic_growth_arrest1.17405601
52MP0003315_abnormal_perineum_morphology1.15989350
53MP0005380_embryogenesis_phenotype1.15947018
54MP0001672_abnormal_embryogenesis/_devel1.15947018
55MP0006072_abnormal_retinal_apoptosis1.14246741
56MP0000778_abnormal_nervous_system1.13398870
57MP0003861_abnormal_nervous_system1.13309382
58MP0009697_abnormal_copulation1.12104536
59MP0001177_atelectasis1.10842367
60MP0005253_abnormal_eye_physiology1.06348567
61MP0001299_abnormal_eye_distance/1.05556884
62MP0005645_abnormal_hypothalamus_physiol1.03007439
63MP0001929_abnormal_gametogenesis1.02301969
64MP0002822_catalepsy1.02261856
65MP0003755_abnormal_palate_morphology1.02215009
66MP0002111_abnormal_tail_morphology1.02076079
67MP0004197_abnormal_fetal_growth/weight/1.01551229
68MP0001486_abnormal_startle_reflex1.01194678
69MP0000383_abnormal_hair_follicle1.01164275
70MP0003984_embryonic_growth_retardation0.99610880
71MP0001697_abnormal_embryo_size0.98973704
72MP0002210_abnormal_sex_determination0.98865630
73MP0001485_abnormal_pinna_reflex0.98813316
74MP0002088_abnormal_embryonic_growth/wei0.98071883
75MP0000566_synostosis0.96455874
76MP0000350_abnormal_cell_proliferation0.95798627
77MP0002653_abnormal_ependyma_morphology0.94537791
78MP0000647_abnormal_sebaceous_gland0.94502453
79MP0005551_abnormal_eye_electrophysiolog0.94147043
80MP0001968_abnormal_touch/_nociception0.93885982
81MP0001145_abnormal_male_reproductive0.92136685
82MP0003786_premature_aging0.91560870
83MP0002638_abnormal_pupillary_reflex0.90078335
84MP0003698_abnormal_male_reproductive0.88796678
85MP0000653_abnormal_sex_gland0.87678113
86MP0010030_abnormal_orbit_morphology0.87370226
87MP0010307_abnormal_tumor_latency0.85306572
88MP0000579_abnormal_nail_morphology0.85256338
89MP0005391_vision/eye_phenotype0.83630099
90MP0003935_abnormal_craniofacial_develop0.83284894
91MP0002080_prenatal_lethality0.81998630
92MP0005395_other_phenotype0.79173362
93MP0006035_abnormal_mitochondrial_morpho0.76777092
94MP0000428_abnormal_craniofacial_morphol0.76705697
95MP0002090_abnormal_vision0.76230608
96MP0002735_abnormal_chemical_nociception0.75405746
97MP0000432_abnormal_head_morphology0.72531316
98MP0002557_abnormal_social/conspecific_i0.72299043
99MP0005187_abnormal_penis_morphology0.70554550
100MP0003646_muscle_fatigue0.70330426

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.09641565
2Colon cancer (HP:0003003)3.91609081
3Septo-optic dysplasia (HP:0100842)3.38962523
4Ependymoma (HP:0002888)2.96203355
5Nephroblastoma (Wilms tumor) (HP:0002667)2.78718987
6Hepatoblastoma (HP:0002884)2.77609800
7Medulloblastoma (HP:0002885)2.76939599
8Hyperglycinemia (HP:0002154)2.65681246
9Abnormal lung lobation (HP:0002101)2.65639685
10Embryonal renal neoplasm (HP:0011794)2.64956511
11Cortical dysplasia (HP:0002539)2.62634053
12Intestinal atresia (HP:0011100)2.59838261
13Aplasia/Hypoplasia of the sternum (HP:0006714)2.59156667
14Birth length less than 3rd percentile (HP:0003561)2.56848634
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53220684
16Chromsome breakage (HP:0040012)2.50873970
17Meckel diverticulum (HP:0002245)2.46224666
18Rhabdomyosarcoma (HP:0002859)2.43776836
19Abnormality of the ileum (HP:0001549)2.42986576
20Stenosis of the external auditory canal (HP:0000402)2.39135047
21Abnormal hair whorl (HP:0010721)2.38410675
22Abnormality of the septum pellucidum (HP:0007375)2.33319461
23Glioma (HP:0009733)2.28014686
24Abnormality of chromosome stability (HP:0003220)2.27962637
25Multiple enchondromatosis (HP:0005701)2.25191376
26Bifid tongue (HP:0010297)2.24823985
27Optic nerve hypoplasia (HP:0000609)2.24264223
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21861503
29Gonadotropin excess (HP:0000837)2.20821219
30Astrocytoma (HP:0009592)2.20655021
31Abnormality of the astrocytes (HP:0100707)2.20655021
32Supernumerary spleens (HP:0009799)2.19888442
33Absent septum pellucidum (HP:0001331)2.17905939
34Absent radius (HP:0003974)2.15980157
35Bilateral microphthalmos (HP:0007633)2.15429048
36Aplasia involving forearm bones (HP:0009822)2.14617892
37Absent forearm bone (HP:0003953)2.14617892
38Agnosia (HP:0010524)2.14531460
39Volvulus (HP:0002580)2.14499285
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.13952663
41Spastic diplegia (HP:0001264)2.10440384
42Methylmalonic acidemia (HP:0002912)2.08462268
43Hypoplastic female external genitalia (HP:0012815)2.08411147
44Abnormality of glycine metabolism (HP:0010895)2.06161912
45Abnormality of serine family amino acid metabolism (HP:0010894)2.06161912
46Abnormality of the parathyroid morphology (HP:0011766)2.04977391
47Labial hypoplasia (HP:0000066)2.04964612
48Genital tract atresia (HP:0001827)2.02925542
49Neoplasm of the adrenal cortex (HP:0100641)2.02150830
50Vaginal atresia (HP:0000148)2.01732430
51Carpal bone hypoplasia (HP:0001498)2.01669654
52Pendular nystagmus (HP:0012043)2.01553206
53Cupped ear (HP:0000378)1.99866412
54Hyperglycinuria (HP:0003108)1.99452357
55Gastrointestinal atresia (HP:0002589)1.98066244
56Abnormality of the duodenum (HP:0002246)1.97858945
57Small intestinal stenosis (HP:0012848)1.96563241
58Duodenal stenosis (HP:0100867)1.96563241
59Neoplasm of the oral cavity (HP:0100649)1.96445319
60Scrotal hypoplasia (HP:0000046)1.96389666
61Pancreatic cysts (HP:0001737)1.95999113
62Sloping forehead (HP:0000340)1.95356579
63Protruding tongue (HP:0010808)1.95088082
64Abnormality of serum amino acid levels (HP:0003112)1.93776783
65Progressive inability to walk (HP:0002505)1.90354335
66Chronic bronchitis (HP:0004469)1.87259453
67True hermaphroditism (HP:0010459)1.86754086
68Ectopic kidney (HP:0000086)1.85781682
69Esophageal atresia (HP:0002032)1.84864411
70Renal hypoplasia (HP:0000089)1.83515118
71Chronic hepatic failure (HP:0100626)1.83215124
72Growth hormone deficiency (HP:0000824)1.82587072
73Patellar aplasia (HP:0006443)1.82370881
74Choanal stenosis (HP:0000452)1.82204679
75Anophthalmia (HP:0000528)1.81968217
76Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81950159
77Dandy-Walker malformation (HP:0001305)1.81688829
78Maternal diabetes (HP:0009800)1.79514624
79Abnormality of the preputium (HP:0100587)1.79206544
80Neoplasm of striated muscle (HP:0009728)1.77086637
81Breast aplasia (HP:0100783)1.75640530
82Drooling (HP:0002307)1.75421767
83Molar tooth sign on MRI (HP:0002419)1.75374878
84Abnormality of midbrain morphology (HP:0002418)1.75374878
85Micropenis (HP:0000054)1.74481339
86Preaxial hand polydactyly (HP:0001177)1.74317330
87Aqueductal stenosis (HP:0002410)1.73555691
88Homocystinuria (HP:0002156)1.73466509
89Abnormality of homocysteine metabolism (HP:0010919)1.73466509
90Pancreatic fibrosis (HP:0100732)1.73150659
91Medial flaring of the eyebrow (HP:0010747)1.73109037
92Embryonal neoplasm (HP:0002898)1.70460681
93Broad foot (HP:0001769)1.70314371
94Triphalangeal thumb (HP:0001199)1.69993772
95Lissencephaly (HP:0001339)1.69826592
96Abnormality of the clitoris (HP:0000056)1.69340315
97Horseshoe kidney (HP:0000085)1.68089380
98Nephrogenic diabetes insipidus (HP:0009806)1.67567187
99Clitoromegaly (HP:0000057)1.64475345
100Congenital primary aphakia (HP:0007707)1.63534473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.13104302
2TSSK63.05688835
3MKNK22.97940628
4TNIK2.96538274
5WNK32.93248897
6MKNK12.75250386
7CDC72.71344198
8TTK2.57158477
9FRK2.32421389
10TRIM282.32185549
11BUB12.32153544
12ZAK2.26395038
13CASK2.19388440
14PLK32.17619646
15BRD42.01943288
16PLK41.98766606
17NUAK11.96969450
18MAP3K41.87438200
19WEE11.72967966
20CAMK1D1.64749348
21TAF11.64220095
22PNCK1.61136200
23BRSK21.59522034
24CAMK1G1.58167605
25BCR1.56188585
26DYRK21.55484932
27PBK1.50748070
28EIF2AK31.48326069
29BMPR1B1.46644195
30VRK21.45462825
31ACVR1B1.44281422
32VRK11.42766079
33NEK11.34540397
34DYRK31.29038891
35CSNK1G11.25661474
36PLK11.24102420
37STK38L1.19544612
38FGFR21.15146732
39PLK21.11370842
40MARK11.11015907
41CSNK1G21.07926784
42RPS6KA41.00823120
43CDK190.98840925
44STK160.97532909
45ATR0.95794297
46ATM0.93305664
47CHEK20.92908264
48MAP2K70.92781333
49CSNK1G30.90077652
50YES10.89267329
51MAP4K20.89210602
52CSNK1A1L0.89128537
53TGFBR10.87909156
54MST40.87309056
55ERBB40.81026295
56NME10.80640591
57MAPK130.79879943
58PASK0.74803380
59FGFR10.73047451
60NLK0.72404276
61CHEK10.71042326
62STK30.70361123
63OXSR10.66170929
64NEK20.64395910
65PDK20.63540783
66AURKB0.62626329
67EIF2AK20.59495138
68AKT30.54229229
69TAOK10.54106401
70CDK30.52738977
71LATS10.52100433
72EPHA40.50663073
73GRK10.50486898
74BCKDK0.49456434
75CDK10.49182170
76PRKCG0.48964414
77CSNK1E0.48471421
78INSRR0.48090125
79PRKCE0.47918938
80DYRK1A0.47075809
81PRKDC0.46509823
82CCNB10.46030430
83TIE10.45707205
84CDK20.45370229
85MAP3K100.42580664
86CDK70.42167234
87ADRBK20.42080919
88MINK10.41935984
89FER0.40793470
90ALK0.39819816
91AURKA0.36315051
92CSNK2A20.35047643
93ERBB30.34998243
94CSNK2A10.34298984
95RPS6KA50.32432708
96PINK10.31734896
97EPHA30.30944696
98GSK3B0.30629242
99PRKCI0.30471057
100SGK20.30093207

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.82564511
2Mismatch repair_Homo sapiens_hsa034303.10252214
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89932801
4DNA replication_Homo sapiens_hsa030302.84566661
5Homologous recombination_Homo sapiens_hsa034402.55962213
6Fanconi anemia pathway_Homo sapiens_hsa034602.49910896
7RNA polymerase_Homo sapiens_hsa030202.45874469
8Basal transcription factors_Homo sapiens_hsa030222.42877030
9RNA transport_Homo sapiens_hsa030132.42307845
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40150399
11Propanoate metabolism_Homo sapiens_hsa006402.34049716
12Base excision repair_Homo sapiens_hsa034102.24041993
13Spliceosome_Homo sapiens_hsa030402.19042244
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.12827817
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10466628
16Steroid biosynthesis_Homo sapiens_hsa001002.08873275
17Protein export_Homo sapiens_hsa030602.06706831
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05675233
19Selenocompound metabolism_Homo sapiens_hsa004502.03449802
20RNA degradation_Homo sapiens_hsa030181.99464395
21Proteasome_Homo sapiens_hsa030501.97639597
22Cell cycle_Homo sapiens_hsa041101.94690043
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80536321
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69762728
25One carbon pool by folate_Homo sapiens_hsa006701.68578943
26Nucleotide excision repair_Homo sapiens_hsa034201.51566161
27mRNA surveillance pathway_Homo sapiens_hsa030151.51409671
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37704655
29Butanoate metabolism_Homo sapiens_hsa006501.35083987
30Nicotine addiction_Homo sapiens_hsa050331.34413125
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33064914
32Fatty acid elongation_Homo sapiens_hsa000621.21038198
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15188693
34Purine metabolism_Homo sapiens_hsa002301.14787432
35Pyruvate metabolism_Homo sapiens_hsa006201.13003120
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11812084
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10673020
38Oocyte meiosis_Homo sapiens_hsa041141.06655163
39Lysine degradation_Homo sapiens_hsa003101.02096815
40Pyrimidine metabolism_Homo sapiens_hsa002401.00993924
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00114933
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97369587
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96146505
44Vitamin B6 metabolism_Homo sapiens_hsa007500.90637559
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90436276
46beta-Alanine metabolism_Homo sapiens_hsa004100.89869329
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86525596
48Biosynthesis of amino acids_Homo sapiens_hsa012300.83596794
49Huntingtons disease_Homo sapiens_hsa050160.82359387
50Phototransduction_Homo sapiens_hsa047440.82116695
51Taste transduction_Homo sapiens_hsa047420.81272276
52Basal cell carcinoma_Homo sapiens_hsa052170.78636623
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75890229
54Fatty acid metabolism_Homo sapiens_hsa012120.75134743
55p53 signaling pathway_Homo sapiens_hsa041150.73965707
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73881939
57Adherens junction_Homo sapiens_hsa045200.73334460
58TGF-beta signaling pathway_Homo sapiens_hsa043500.69844304
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68473588
60Parkinsons disease_Homo sapiens_hsa050120.68343508
61Tight junction_Homo sapiens_hsa045300.67263480
62Wnt signaling pathway_Homo sapiens_hsa043100.67099561
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.66528313
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66491190
65Hippo signaling pathway_Homo sapiens_hsa043900.65156940
66Carbon metabolism_Homo sapiens_hsa012000.63792013
67Hedgehog signaling pathway_Homo sapiens_hsa043400.63431293
68Fatty acid biosynthesis_Homo sapiens_hsa000610.63131932
69Peroxisome_Homo sapiens_hsa041460.62415230
70Glutathione metabolism_Homo sapiens_hsa004800.61825404
71Tryptophan metabolism_Homo sapiens_hsa003800.60188819
72Ether lipid metabolism_Homo sapiens_hsa005650.58045773
73Metabolic pathways_Homo sapiens_hsa011000.57083233
74Oxidative phosphorylation_Homo sapiens_hsa001900.56867031
75Nitrogen metabolism_Homo sapiens_hsa009100.55823952
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54411033
77Vitamin digestion and absorption_Homo sapiens_hsa049770.52437090
78Arginine and proline metabolism_Homo sapiens_hsa003300.45325940
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43518070
80Fatty acid degradation_Homo sapiens_hsa000710.40232128
81MicroRNAs in cancer_Homo sapiens_hsa052060.39971575
82Olfactory transduction_Homo sapiens_hsa047400.38793180
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37905835
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36468624
85Colorectal cancer_Homo sapiens_hsa052100.35745817
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33781379
87Alcoholism_Homo sapiens_hsa050340.32428332
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30925640
89Axon guidance_Homo sapiens_hsa043600.30197790
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27079087
91GABAergic synapse_Homo sapiens_hsa047270.26857859
92Linoleic acid metabolism_Homo sapiens_hsa005910.25997258
93Circadian rhythm_Homo sapiens_hsa047100.25554625
94Ribosome_Homo sapiens_hsa030100.25467667
95Prostate cancer_Homo sapiens_hsa052150.25062963
96Renin-angiotensin system_Homo sapiens_hsa046140.25015807
97Regulation of autophagy_Homo sapiens_hsa041400.24901644
98Long-term depression_Homo sapiens_hsa047300.22263440
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20523487
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19543400

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