ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.20837901
2	regulation of translation, ncRNA-mediated (GO:0045974)	4.20837901
3	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.20837901
4	protein K11-linked deubiquitination (GO:0035871)	3.83973132
5	establishment of protein localization to Golgi (GO:0072600)	3.82946730
6	early endosome to late endosome transport (GO:0045022)	3.74395408
7	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.48968232
8	protein targeting to Golgi (GO:0000042)	3.47245974
9	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.38673915
10	interkinetic nuclear migration (GO:0022027)	3.26016188
11	protein targeting to vacuole (GO:0006623)	3.22747318
12	protein targeting to lysosome (GO:0006622)	3.22747318
13	establishment of protein localization to vacuole (GO:0072666)	3.22747318
14	negative regulation of systemic arterial blood pressure (GO:0003085)	3.20702956
15	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.17338780
16	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.17338780
17	startle response (GO:0001964)	3.13544610
18	Golgi to endosome transport (GO:0006895)	3.10462149
19	prostate gland growth (GO:0060736)	3.08034346
20	reflex (GO:0060004)	2.95238537
21	peptidyl-threonine dephosphorylation (GO:0035970)	2.94556094
22	neural tube formation (GO:0001841)	2.93410219
23	histone H3-K4 trimethylation (GO:0080182)	2.84441348
24	sulfation (GO:0051923)	2.84096646
25	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.83966784
26	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.83966784
27	genitalia morphogenesis (GO:0035112)	2.83136386
28	dentate gyrus development (GO:0021542)	2.82041961
29	cellular response to ethanol (GO:0071361)	2.81695382
30	cytoplasmic mRNA processing body assembly (GO:0033962)	2.80087839
31	kidney morphogenesis (GO:0060993)	2.78951621
32	protein K48-linked deubiquitination (GO:0071108)	2.76883130
33	presynaptic membrane assembly (GO:0097105)	2.75689012
34	cerebellar Purkinje cell differentiation (GO:0021702)	2.75485250
35	protein localization to Golgi apparatus (GO:0034067)	2.75177610
36	behavioral response to nicotine (GO:0035095)	2.74638164
37	adaptation of signaling pathway (GO:0023058)	2.65581690
38	regulation of acrosome reaction (GO:0060046)	2.64233518
39	L-fucose catabolic process (GO:0042355)	2.60705076
40	fucose catabolic process (GO:0019317)	2.60705076
41	L-fucose metabolic process (GO:0042354)	2.60705076
42	negative regulation of hormone biosynthetic process (GO:0032353)	2.59053922
43	presynaptic membrane organization (GO:0097090)	2.57642772
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.55392607
45	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.53027947
46	multicellular organism reproduction (GO:0032504)	2.51519469
47	macroautophagy (GO:0016236)	2.49584556
48	regulation of establishment of cell polarity (GO:2000114)	2.49103502
49	activated T cell proliferation (GO:0050798)	2.48530221
50	microtubule anchoring (GO:0034453)	2.44205372
51	auditory behavior (GO:0031223)	2.43247749
52	positive regulation of glycolytic process (GO:0045821)	2.42676235
53	pyrimidine nucleobase catabolic process (GO:0006208)	2.41082249
54	monoubiquitinated protein deubiquitination (GO:0035520)	2.40550213
55	negative regulation of Ras GTPase activity (GO:0034261)	2.39848710
56	intestinal epithelial cell development (GO:0060576)	2.38874720
57	DNA methylation involved in gamete generation (GO:0043046)	2.36241797
58	positive regulation of mRNA catabolic process (GO:0061014)	2.36010716
59	piRNA metabolic process (GO:0034587)	2.35607854
60	spinal cord motor neuron differentiation (GO:0021522)	2.35384442
61	peptidyl-lysine trimethylation (GO:0018023)	2.34882014
62	keratinocyte development (GO:0003334)	2.31646033
63	intra-Golgi vesicle-mediated transport (GO:0006891)	2.31582629
64	otic vesicle formation (GO:0030916)	2.30335951
65	regulation of female receptivity (GO:0045924)	2.28458595
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.27547291
67	oocyte development (GO:0048599)	2.25883505
68	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.24885829
69	nucleus localization (GO:0051647)	2.24862162
70	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.24768775
71	protein polyglutamylation (GO:0018095)	2.24660294
72	prenylation (GO:0097354)	2.24401399
73	protein prenylation (GO:0018342)	2.24401399
74	regulation of protein polyubiquitination (GO:1902914)	2.22454480
75	regulation of meiosis I (GO:0060631)	2.22386026
76	cell proliferation in forebrain (GO:0021846)	2.22277553
77	histone H3-K9 demethylation (GO:0033169)	2.21928211
78	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.21647706
79	regulation of memory T cell differentiation (GO:0043380)	2.21469063
80	neuronal action potential (GO:0019228)	2.21433735
81	indolalkylamine metabolic process (GO:0006586)	2.21303134
82	protein localization to lysosome (GO:0061462)	2.18749990
83	protein localization to vacuole (GO:0072665)	2.18749990
84	endocrine pancreas development (GO:0031018)	2.18332759
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.18190904
86	retina layer formation (GO:0010842)	2.17930051
87	regulation of hexokinase activity (GO:1903299)	2.17237661
88	regulation of glucokinase activity (GO:0033131)	2.17237661
89	labyrinthine layer development (GO:0060711)	2.17072452
90	negative regulation of protein oligomerization (GO:0032460)	2.16969114
91	interleukin-6-mediated signaling pathway (GO:0070102)	2.15968363
92	RNA destabilization (GO:0050779)	2.15294620
93	vacuolar transport (GO:0007034)	2.15251131
94	lysosomal transport (GO:0007041)	2.14808666
95	limb development (GO:0060173)	2.14788654
96	appendage development (GO:0048736)	2.14788654
97	histone H3-K9 methylation (GO:0051567)	2.14776476
98	regulation of collateral sprouting (GO:0048670)	2.14663244
99	endosome to lysosome transport (GO:0008333)	2.14499412
100	positive regulation of meiosis (GO:0045836)	2.14477490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.31277626
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.17980870
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.98802756
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78302430
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.77928728
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.74066282
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40247425
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36363346
9	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.22842283
10	VDR_22108803_ChIP-Seq_LS180_Human	2.19740103
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18057858
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.15589582
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07879387
14	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.04539675
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.03093404
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00479302
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.97278953
18	* TAF15_26573619_Chip-Seq_HEK293_Human	1.94865570
19	FUS_26573619_Chip-Seq_HEK293_Human	1.94822901
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.94636497
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86626400
22	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.86326268
23	AHR_22903824_ChIP-Seq_MCF-7_Human	1.80498620
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79624766
25	P300_19829295_ChIP-Seq_ESCs_Human	1.78437367
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.78262685
27	EWS_26573619_Chip-Seq_HEK293_Human	1.75673311
28	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.73700029
29	* STAT3_23295773_ChIP-Seq_U87_Human	1.71668337
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.67020294
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66489586
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66443317
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64619103
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64551198
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61394386
36	TCF4_23295773_ChIP-Seq_U87_Human	1.59965523
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54410789
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53899718
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53899718
40	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.53425606
41	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.50541121
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50272110
43	AR_25329375_ChIP-Seq_VCAP_Human	1.43008850
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42630915
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40521899
46	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40126682
47	* CBP_20019798_ChIP-Seq_JUKART_Human	1.39902558
48	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39902558
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38935485
50	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37833998
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37070280
52	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.34531587
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32995515
54	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.30190847
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29763721
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28077998
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28046195
58	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.27008808
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26997866
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26665747
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25889070
62	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25595420
63	TP53_16413492_ChIP-PET_HCT116_Human	1.24276407
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23444403
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.16903959
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16585990
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14741480
68	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13931995
69	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13842574
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13372391
71	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11539940
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11379745
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10027984
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09892534
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09398424
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07293934
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06945251
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06608358
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.06523531
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06408176
81	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05975195
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05730952
83	KDM2B_26808549_Chip-Seq_REH_Human	1.04349759
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04203967
85	DROSHA_22980978_ChIP-Seq_HELA_Human	1.02498566
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01937240
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01273322
88	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01000873
89	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.00603431
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00363759
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00278071
92	RXR_22108803_ChIP-Seq_LS180_Human	0.99461469
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97998308
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97447196
95	RUNX_20019798_ChIP-Seq_JUKART_Human	0.97429397
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96058622
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95392573
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94229330
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92676888
100	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.92492323

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.80987569
2	MP0003787_abnormal_imprinting	4.12011069
3	MP0008877_abnormal_DNA_methylation	3.57709873
4	MP0003195_calcinosis	2.83431794
5	MP0000427_abnormal_hair_cycle	2.69240959
6	MP0005075_abnormal_melanosome_morpholog	2.12157923
7	MP0002009_preneoplasia	2.03026551
8	MP0005174_abnormal_tail_pigmentation	2.02287537
9	MP0001984_abnormal_olfaction	2.01979703
10	MP0004381_abnormal_hair_follicle	1.93069885
11	MP0003121_genomic_imprinting	1.92900667
12	MP0003724_increased_susceptibility_to	1.89810481
13	MP0000383_abnormal_hair_follicle	1.88564161
14	MP0006292_abnormal_olfactory_placode	1.85459258
15	MP0003183_abnormal_peptide_metabolism	1.85408386
16	MP0008057_abnormal_DNA_replication	1.80546066
17	MP0005646_abnormal_pituitary_gland	1.78295268
18	MP0002138_abnormal_hepatobiliary_system	1.74740442
19	MP0004885_abnormal_endolymph	1.69769396
20	MP0001485_abnormal_pinna_reflex	1.69635969
21	MP0003122_maternal_imprinting	1.67128005
22	MP0005551_abnormal_eye_electrophysiolog	1.66214481
23	MP0000631_abnormal_neuroendocrine_gland	1.61736481
24	MP0003890_abnormal_embryonic-extraembry	1.59901868
25	MP0002102_abnormal_ear_morphology	1.55955342
26	MP0010678_abnormal_skin_adnexa	1.53479915
27	MP0001486_abnormal_startle_reflex	1.49290319
28	MP0002928_abnormal_bile_duct	1.48313486
29	MP0000372_irregular_coat_pigmentation	1.47733636
30	MP0004130_abnormal_muscle_cell	1.47385200
31	MP0003136_yellow_coat_color	1.44007370
32	MP0000015_abnormal_ear_pigmentation	1.41581679
33	MP0003646_muscle_fatigue	1.34942166
34	MP0004134_abnormal_chest_morphology	1.29876526
35	MP0002909_abnormal_adrenal_gland	1.27639983
36	MP0002277_abnormal_respiratory_mucosa	1.24392831
37	MP0002735_abnormal_chemical_nociception	1.23530812
38	MP0002272_abnormal_nervous_system	1.19965144
39	MP0005253_abnormal_eye_physiology	1.17180577
40	MP0003880_abnormal_central_pattern	1.15840544
41	MP0001986_abnormal_taste_sensitivity	1.15356206
42	MP0009780_abnormal_chondrocyte_physiolo	1.14981162
43	MP0004043_abnormal_pH_regulation	1.13076574
44	MP0004142_abnormal_muscle_tone	1.10960544
45	MP0001968_abnormal_touch/_nociception	1.09506437
46	MP0000371_diluted_coat_color	1.09435471
47	MP0002160_abnormal_reproductive_system	1.07439456
48	MP0003252_abnormal_bile_duct	1.07039956
49	MP0004924_abnormal_behavior	1.06890410
50	MP0005386_behavior/neurological_phenoty	1.06890410
51	MP0002638_abnormal_pupillary_reflex	1.05408861
52	MP0001324_abnormal_eye_pigmentation	1.03472403
53	MP0000470_abnormal_stomach_morphology	1.03241927
54	MP0002876_abnormal_thyroid_physiology	1.03038969
55	MP0003011_delayed_dark_adaptation	1.02088834
56	MP0009745_abnormal_behavioral_response	1.01755288
57	MP0005083_abnormal_biliary_tract	1.01504825
58	MP0002653_abnormal_ependyma_morphology	1.01345225
59	MP0005220_abnormal_exocrine_pancreas	0.98393817
60	MP0008872_abnormal_physiological_respon	0.97879744
61	MP0005248_abnormal_Harderian_gland	0.96893483
62	MP0002693_abnormal_pancreas_physiology	0.94307470
63	MP0000778_abnormal_nervous_system	0.94286669
64	MP0002166_altered_tumor_susceptibility	0.93888514
65	MP0005645_abnormal_hypothalamus_physiol	0.92633454
66	MP0002557_abnormal_social/conspecific_i	0.91783687
67	MP0005389_reproductive_system_phenotype	0.90517268
68	MP0005310_abnormal_salivary_gland	0.88768204
69	MP0001440_abnormal_grooming_behavior	0.87887556
70	MP0002095_abnormal_skin_pigmentation	0.87851262
71	MP0003635_abnormal_synaptic_transmissio	0.85256005
72	MP0002067_abnormal_sensory_capabilities	0.84339087
73	MP0001919_abnormal_reproductive_system	0.82640445
74	MP0001944_abnormal_pancreas_morphology	0.82551810
75	MP0009046_muscle_twitch	0.80458263
76	MP0004264_abnormal_extraembryonic_tissu	0.79750077
77	MP0002734_abnormal_mechanical_nocicepti	0.78852207
78	MP0002751_abnormal_autonomic_nervous	0.78753795
79	MP0002064_seizures	0.77598875
80	MP0006276_abnormal_autonomic_nervous	0.77052708
81	MP0003633_abnormal_nervous_system	0.76650704
82	MP0002282_abnormal_trachea_morphology	0.75507335
83	MP0002572_abnormal_emotion/affect_behav	0.75037767
84	MP0000465_gastrointestinal_hemorrhage	0.74436267
85	MP0001929_abnormal_gametogenesis	0.73788526
86	MP0001664_abnormal_digestion	0.73220073
87	MP0001188_hyperpigmentation	0.72889434
88	MP0002063_abnormal_learning/memory/cond	0.72710160
89	MP0000613_abnormal_salivary_gland	0.72690582
90	MP0003938_abnormal_ear_development	0.72569741
91	MP0001765_abnormal_ion_homeostasis	0.72511991
92	MP0004270_analgesia	0.72490386
93	MP0008961_abnormal_basal_metabolism	0.72020364
94	MP0008995_early_reproductive_senescence	0.71349375
95	MP0003698_abnormal_male_reproductive	0.71221214
96	MP0004484_altered_response_of	0.71045616
97	MP0003045_fibrosis	0.70107320
98	MP0000516_abnormal_urinary_system	0.69816191
99	MP0005367_renal/urinary_system_phenotyp	0.69816191
100	MP0005379_endocrine/exocrine_gland_phen	0.69722730

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	3.80593661
2	Progressive cerebellar ataxia (HP:0002073)	3.54462527
3	Pancreatic cysts (HP:0001737)	3.29537306
4	Stomach cancer (HP:0012126)	3.08536458
5	Hypothermia (HP:0002045)	2.95983935
6	Pancreatic fibrosis (HP:0100732)	2.90495571
7	Gaze-evoked nystagmus (HP:0000640)	2.82453442
8	True hermaphroditism (HP:0010459)	2.79895485
9	Truncal obesity (HP:0001956)	2.72308237
10	Agitation (HP:0000713)	2.69751137
11	Hyperventilation (HP:0002883)	2.67374773
12	Thyroiditis (HP:0100646)	2.53583341
13	Abnormality of the renal cortex (HP:0011035)	2.52347125
14	Neoplasm of the tracheobronchial system (HP:0100552)	2.47999788
15	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.47440883
16	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.47440883
17	Nephronophthisis (HP:0000090)	2.39115298
18	Neoplasm of the heart (HP:0100544)	2.38305268
19	Papillary thyroid carcinoma (HP:0002895)	2.37529431
20	Chronic hepatic failure (HP:0100626)	2.36379007
21	Astrocytoma (HP:0009592)	2.36149630
22	Abnormality of the astrocytes (HP:0100707)	2.36149630
23	Fair hair (HP:0002286)	2.36054836
24	Concave nail (HP:0001598)	2.34389135
25	Aqueductal stenosis (HP:0002410)	2.33932498
26	Generalized hypopigmentation of hair (HP:0011358)	2.30436975
27	Ependymoma (HP:0002888)	2.29806704
28	Abnormality of the renal medulla (HP:0100957)	2.28800688
29	Hip dysplasia (HP:0001385)	2.23591918
30	Medial flaring of the eyebrow (HP:0010747)	2.22922884
31	Abolished electroretinogram (ERG) (HP:0000550)	2.21773318
32	Volvulus (HP:0002580)	2.21234624
33	Ketoacidosis (HP:0001993)	2.19608151
34	Macroorchidism (HP:0000053)	2.18739204
35	Neoplasm of the adrenal cortex (HP:0100641)	2.17854920
36	Glioma (HP:0009733)	2.17215450
37	Oligodactyly (hands) (HP:0001180)	2.13211849
38	Alveolar cell carcinoma (HP:0006519)	2.12022232
39	Decreased circulating renin level (HP:0003351)	2.11465825
40	Febrile seizures (HP:0002373)	2.10889561
41	Tubulointerstitial nephritis (HP:0001970)	2.07921056
42	Genital tract atresia (HP:0001827)	2.06379516
43	Inability to walk (HP:0002540)	2.05216259
44	Hamartoma of the eye (HP:0010568)	2.02100371
45	Abnormality of the nasal septum (HP:0000419)	2.00934464
46	Molar tooth sign on MRI (HP:0002419)	2.00664339
47	Abnormality of midbrain morphology (HP:0002418)	2.00664339
48	Decreased central vision (HP:0007663)	1.99150570
49	Vaginal atresia (HP:0000148)	1.94938494
50	Thyroid carcinoma (HP:0002890)	1.94756484
51	Hypochromic microcytic anemia (HP:0004840)	1.93417530
52	Protruding tongue (HP:0010808)	1.93370049
53	Abnormal pancreas size (HP:0012094)	1.92495038
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92421516
55	Abnormality of the corticospinal tract (HP:0002492)	1.90244982
56	Cystic liver disease (HP:0006706)	1.89940674
57	Widely spaced teeth (HP:0000687)	1.88399193
58	Furrowed tongue (HP:0000221)	1.86151866
59	Hypoplastic iliac wings (HP:0002866)	1.85515083
60	Broad-based gait (HP:0002136)	1.84665532
61	Hamartoma (HP:0010566)	1.82931064
62	Poor coordination (HP:0002370)	1.81095822
63	Hemiplegia (HP:0002301)	1.79214328
64	Blue irides (HP:0000635)	1.78853423
65	Renal cortical cysts (HP:0000803)	1.78370814
66	Increased corneal curvature (HP:0100692)	1.77689837
67	Keratoconus (HP:0000563)	1.77689837
68	Gait imbalance (HP:0002141)	1.76473384
69	Abnormality of the axillary hair (HP:0100134)	1.75435919
70	Abnormality of secondary sexual hair (HP:0009888)	1.75435919
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.73889242
72	Attenuation of retinal blood vessels (HP:0007843)	1.73601183
73	Epileptiform EEG discharges (HP:0011182)	1.72049254
74	Hypsarrhythmia (HP:0002521)	1.71799539
75	Congenital stationary night blindness (HP:0007642)	1.71643970
76	EEG with generalized epileptiform discharges (HP:0011198)	1.70780843
77	Large for gestational age (HP:0001520)	1.69532843
78	Pendular nystagmus (HP:0012043)	1.69486181
79	Narrow palate (HP:0000189)	1.67449528
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67416216
81	Male pseudohermaphroditism (HP:0000037)	1.67331007
82	Congenital primary aphakia (HP:0007707)	1.67226010
83	Congenital malformation of the right heart (HP:0011723)	1.65409470
84	Double outlet right ventricle (HP:0001719)	1.65409470
85	Dysdiadochokinesis (HP:0002075)	1.64284276
86	Neoplasm of striated muscle (HP:0009728)	1.64040688
87	Calf muscle hypertrophy (HP:0008981)	1.63872549
88	Urinary bladder sphincter dysfunction (HP:0002839)	1.62743315
89	Hypoplastic labia majora (HP:0000059)	1.62523587
90	Curly hair (HP:0002212)	1.61476798
91	Tented upper lip vermilion (HP:0010804)	1.61278284
92	Menstrual irregularities (HP:0000858)	1.60872819
93	Disproportionate short-trunk short stature (HP:0003521)	1.59973962
94	Severe Myopia (HP:0011003)	1.59745863
95	Neoplasm of the oral cavity (HP:0100649)	1.59609402
96	Nephrogenic diabetes insipidus (HP:0009806)	1.59201112
97	Absent/shortened dynein arms (HP:0200106)	1.59103226
98	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.59103226
99	Growth hormone deficiency (HP:0000824)	1.59074571
100	Hematochezia (HP:0002573)	1.57992847

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.01464600
2	TRIM28	3.50745886
3	FGFR2	2.46905114
4	AKT3	2.41370155
5	PINK1	2.23412787
6	SGK2	2.00826764
7	BMPR1B	1.98244305
8	TAOK3	1.89696815
9	STK39	1.88415345
10	NLK	1.82814815
11	ACVR1B	1.73188057
12	EPHA3	1.72743526
13	INSRR	1.72228012
14	WNK3	1.69572640
15	OXSR1	1.64525379
16	NUAK1	1.60081638
17	CASK	1.59239955
18	MAPK13	1.52602546
19	GRK1	1.47036726
20	ADRBK2	1.46236257
21	SGK223	1.40254356
22	SGK494	1.40254356
23	MAP3K4	1.39521468
24	TNK2	1.38266788
25	TNIK	1.36691298
26	LATS1	1.31199255
27	PAK3	1.31187844
28	SGK3	1.28196270
29	BLK	1.26563138
30	CAMK1G	1.25550203
31	FER	1.18094271
32	FGFR3	1.17407201
33	MAP2K4	1.14010515
34	YES1	1.10725300
35	GRK6	1.07408268
36	MAP3K2	1.05927105
37	STK11	1.04650853
38	CAMK1D	1.04186637
39	ERBB2	1.01167123
40	IRAK1	0.98607502
41	PTK2B	0.95354169
42	WNK1	0.93950285
43	PNCK	0.93445212
44	ERBB3	0.90822576
45	MATK	0.88502784
46	MAP4K2	0.87176137
47	CAMKK2	0.86804745
48	DAPK2	0.85965341
49	TXK	0.85592597
50	STK38	0.80390575
51	STK38L	0.78836260
52	TEC	0.78652661
53	SGK1	0.78611970
54	RIPK4	0.78521201
55	WNK4	0.78072302
56	MARK2	0.74326236
57	NEK6	0.71696109
58	OBSCN	0.71004390
59	PRKAA2	0.70616476
60	PKN2	0.70547898
61	JAK1	0.70362185
62	NTRK2	0.69047973
63	CAMK4	0.68907966
64	MAP2K7	0.65577343
65	PIK3CA	0.65310706
66	PRKCZ	0.63656930
67	BRD4	0.63295572
68	TAOK1	0.62219227
69	ADRBK1	0.61005663
70	NTRK3	0.59055431
71	PRKCE	0.57756769
72	CAMK1	0.56979270
73	CHUK	0.56577784
74	PRKCH	0.54824920
75	MKNK2	0.54636634
76	IKBKE	0.53249139
77	PRKD2	0.52771470
78	CSK	0.51943627
79	PRKAA1	0.47331471
80	RET	0.46323024
81	FGFR1	0.45380580
82	BMPR2	0.43674123
83	STK24	0.43358881
84	DYRK1A	0.43148194
85	BRSK2	0.42794972
86	PIK3CG	0.42731373
87	PRKCQ	0.42719755
88	STK3	0.42615337
89	SYK	0.42610405
90	MAP3K7	0.42488752
91	LYN	0.40910636
92	ZAK	0.39845083
93	RPS6KB1	0.39186574
94	BTK	0.38312202
95	HCK	0.37996625
96	PDK1	0.36581725
97	MELK	0.36367484
98	MARK3	0.35249547
99	JAK2	0.34654076
100	PRKCG	0.34517189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.25201598
2	Caffeine metabolism_Homo sapiens_hsa00232	2.31360102
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.22257060
4	Nicotine addiction_Homo sapiens_hsa05033	1.83507597
5	Type II diabetes mellitus_Homo sapiens_hsa04930	1.77191475
6	Taste transduction_Homo sapiens_hsa04742	1.72123656
7	Insulin secretion_Homo sapiens_hsa04911	1.71737256
8	ABC transporters_Homo sapiens_hsa02010	1.65245587
9	Regulation of autophagy_Homo sapiens_hsa04140	1.60911923
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60494447
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56639174
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51447631
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46574938
14	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.41700907
15	Morphine addiction_Homo sapiens_hsa05032	1.39346938
16	Phototransduction_Homo sapiens_hsa04744	1.38532838
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.36119220
18	Circadian rhythm_Homo sapiens_hsa04710	1.32934940
19	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.29409175
20	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.28199724
21	Serotonergic synapse_Homo sapiens_hsa04726	1.27122305
22	Renin secretion_Homo sapiens_hsa04924	1.25575076
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.23349658
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.20562899
25	Circadian entrainment_Homo sapiens_hsa04713	1.19649949
26	mTOR signaling pathway_Homo sapiens_hsa04150	1.18976095
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.17194196
28	FoxO signaling pathway_Homo sapiens_hsa04068	1.16173296
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.15525698
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10698270
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08144379
32	Butanoate metabolism_Homo sapiens_hsa00650	1.05640193
33	Prostate cancer_Homo sapiens_hsa05215	1.03400550
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.03139798
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.03083750
36	GABAergic synapse_Homo sapiens_hsa04727	1.02662083
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02109666
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.02066965
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02027566
40	Long-term depression_Homo sapiens_hsa04730	1.01148547
41	Olfactory transduction_Homo sapiens_hsa04740	0.96595312
42	Calcium signaling pathway_Homo sapiens_hsa04020	0.96428155
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.95998176
44	Salivary secretion_Homo sapiens_hsa04970	0.93345969
45	Endometrial cancer_Homo sapiens_hsa05213	0.92925300
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92347273
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.91677417
48	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.89722450
49	Amphetamine addiction_Homo sapiens_hsa05031	0.88200568
50	Prolactin signaling pathway_Homo sapiens_hsa04917	0.87498139
51	Histidine metabolism_Homo sapiens_hsa00340	0.87430593
52	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.85294246
53	Insulin resistance_Homo sapiens_hsa04931	0.85277097
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85014340
55	Cholinergic synapse_Homo sapiens_hsa04725	0.82967853
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82239446
57	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.82121897
58	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80803123
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80019766
60	Melanoma_Homo sapiens_hsa05218	0.79589024
61	Non-small cell lung cancer_Homo sapiens_hsa05223	0.78113099
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74630649
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74510720
64	Pancreatic secretion_Homo sapiens_hsa04972	0.73009053
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72732979
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.71985961
67	Lysine degradation_Homo sapiens_hsa00310	0.70589904
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70319429
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70173172
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68956553
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68923556
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67434328
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66809133
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.66590937
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.65781280
76	Ras signaling pathway_Homo sapiens_hsa04014	0.64973690
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63943870
78	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63304552
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62546179
80	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62381939
81	Platelet activation_Homo sapiens_hsa04611	0.61263438
82	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.61200872
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61000424
84	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.60771467
85	Cocaine addiction_Homo sapiens_hsa05030	0.60473273
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59807429
87	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.58823772
88	Gastric acid secretion_Homo sapiens_hsa04971	0.56180276
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54997853
90	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54860264
91	Retinol metabolism_Homo sapiens_hsa00830	0.53952749
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51902881
93	ErbB signaling pathway_Homo sapiens_hsa04012	0.51170909
94	Long-term potentiation_Homo sapiens_hsa04720	0.50527023
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50077389
96	Sulfur metabolism_Homo sapiens_hsa00920	0.49587499
97	Peroxisome_Homo sapiens_hsa04146	0.49222224
98	Glioma_Homo sapiens_hsa05214	0.49124537
99	Axon guidance_Homo sapiens_hsa04360	0.47644118
100	Gap junction_Homo sapiens_hsa04540	0.47237182

ZNF652

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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