ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.31390307
2	positive regulation of protein homodimerization activity (GO:0090073)	6.18231140
3	cell proliferation in forebrain (GO:0021846)	5.56016170
4	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.07302186
5	substrate-independent telencephalic tangential migration (GO:0021826)	5.07302186
6	neuronal action potential propagation (GO:0019227)	4.84852695
7	establishment of mitochondrion localization (GO:0051654)	4.50174732
8	forebrain neuron differentiation (GO:0021879)	4.43533666
9	pyrimidine nucleobase catabolic process (GO:0006208)	4.33229388
10	nonmotile primary cilium assembly (GO:0035058)	4.28162370
11	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.19579660
12	postsynaptic membrane organization (GO:0001941)	4.19198362
13	ribosomal small subunit assembly (GO:0000028)	4.02915784
14	mitochondrion transport along microtubule (GO:0047497)	3.97416291
15	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.97416291
16	short-term memory (GO:0007614)	3.88980245
17	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.74902934
18	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.72905143
19	viral transcription (GO:0019083)	3.67368240
20	cerebellar Purkinje cell differentiation (GO:0021702)	3.63090608
21	axonal fasciculation (GO:0007413)	3.60713997
22	translational termination (GO:0006415)	3.56571428
23	chaperone-mediated protein transport (GO:0072321)	3.56543128
24	exploration behavior (GO:0035640)	3.49742177
25	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.46537702
26	negative regulation of heart rate (GO:0010459)	3.44545522
27	vitamin A metabolic process (GO:0006776)	3.44542748
28	somite development (GO:0061053)	3.44296749
29	neurofilament cytoskeleton organization (GO:0060052)	3.41878911
30	spinal cord association neuron differentiation (GO:0021527)	3.37219736
31	nucleobase catabolic process (GO:0046113)	3.33800285
32	negative regulation of mast cell activation (GO:0033004)	3.32328278
33	appendage development (GO:0048736)	3.31738420
34	limb development (GO:0060173)	3.31738420
35	regulation of action potential (GO:0098900)	3.29327802
36	synaptic vesicle maturation (GO:0016188)	3.26604574
37	regulation of DNA endoreduplication (GO:0032875)	3.20755401
38	synaptic transmission, cholinergic (GO:0007271)	3.20454148
39	neurotransmitter-gated ion channel clustering (GO:0072578)	3.19113943
40	ribosomal small subunit biogenesis (GO:0042274)	3.19026875
41	transmission of nerve impulse (GO:0019226)	3.12883637
42	behavioral response to cocaine (GO:0048148)	3.12881536
43	ATP synthesis coupled proton transport (GO:0015986)	3.08663979
44	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.08663979
45	synaptic transmission, glutamatergic (GO:0035249)	3.06691031
46	response to redox state (GO:0051775)	3.06553357
47	behavioral response to ethanol (GO:0048149)	3.05904926
48	auditory behavior (GO:0031223)	3.05561826
49	neuron recognition (GO:0008038)	3.04911313
50	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.04545385
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.03331781
52	endoderm formation (GO:0001706)	3.01454863
53	cotranslational protein targeting to membrane (GO:0006613)	2.94894470
54	body morphogenesis (GO:0010171)	2.94171152
55	protein targeting to ER (GO:0045047)	2.94105225
56	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.93424166
57	positive regulation of growth hormone secretion (GO:0060124)	2.93163291
58	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.92582535
59	regulation of translation, ncRNA-mediated (GO:0045974)	2.92582535
60	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.92582535
61	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.90636526
62	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.89494898
63	regulation of axon regeneration (GO:0048679)	2.85980679
64	regulation of neuron projection regeneration (GO:0070570)	2.85980679
65	cellular component maintenance (GO:0043954)	2.83609613
66	neuromuscular synaptic transmission (GO:0007274)	2.81481479
67	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80462561
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80462561
69	NADH dehydrogenase complex assembly (GO:0010257)	2.80462561
70	presynaptic membrane assembly (GO:0097105)	2.80042235
71	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.79754536
72	protein localization to endoplasmic reticulum (GO:0070972)	2.79738224
73	neuron cell-cell adhesion (GO:0007158)	2.79136011
74	mitochondrion degradation (GO:0000422)	2.77024423
75	camera-type eye morphogenesis (GO:0048593)	2.74631267
76	positive regulation of action potential (GO:0045760)	2.72520097
77	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.72142791
78	viral life cycle (GO:0019058)	2.71122215
79	cellular potassium ion homeostasis (GO:0030007)	2.70227349
80	negative regulation of catecholamine secretion (GO:0033604)	2.69425213
81	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.69350603
82	lens fiber cell differentiation (GO:0070306)	2.68734081
83	translational elongation (GO:0006414)	2.67972355
84	regulation of dopamine secretion (GO:0014059)	2.67515137
85	parturition (GO:0007567)	2.66792575
86	vocalization behavior (GO:0071625)	2.65986085
87	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.64687727
88	cellular protein complex disassembly (GO:0043624)	2.63924330
89	establishment of nucleus localization (GO:0040023)	2.63859709
90	protein complex biogenesis (GO:0070271)	2.63479896
91	protein neddylation (GO:0045116)	2.62013611
92	lysosome localization (GO:0032418)	2.61474473
93	ganglion development (GO:0061548)	2.58566882
94	termination of RNA polymerase I transcription (GO:0006363)	2.57650627
95	protein localization to synapse (GO:0035418)	2.57276192
96	negative regulation of appetite (GO:0032099)	2.57079151
97	negative regulation of response to food (GO:0032096)	2.57079151
98	telencephalon development (GO:0021537)	2.56946522
99	synapse assembly (GO:0007416)	2.56671518
100	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.56125793

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.12477819
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.91840594
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.78035174
4	EZH2_22144423_ChIP-Seq_EOC_Human	4.63608906
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.36110075
6	VDR_22108803_ChIP-Seq_LS180_Human	2.77913571
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.72072265
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.61326027
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.58036924
10	REST_21632747_ChIP-Seq_MESCs_Mouse	2.53234013
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.44902713
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.26883560
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25937034
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.24788566
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.17419209
16	RNF2_27304074_Chip-Seq_NSC_Mouse	2.12938084
17	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.08203952
18	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.07870634
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.03503353
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.95163067
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81439834
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.73589414
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.72797061
24	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.72201394
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70921909
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70167050
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67688671
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67355351
29	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.63083439
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.59239224
31	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.58340277
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57495987
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57495987
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48311333
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48040172
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46688889
37	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.46565357
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46038772
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46038772
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44664652
41	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42907629
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42346066
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.38423032
44	FUS_26573619_Chip-Seq_HEK293_Human	1.35700765
45	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.34000270
46	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.31115746
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.30506627
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29914938
49	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.27924742
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26057944
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.23208992
52	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22361806
53	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21946494
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19606525
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15809313
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13375110
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12627898
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11188002
59	P300_19829295_ChIP-Seq_ESCs_Human	1.10665282
60	DROSHA_22980978_ChIP-Seq_HELA_Human	1.10058664
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.09186695
62	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07330157
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06728297
64	CTCF_27219007_Chip-Seq_Bcells_Human	1.05332528
65	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03657964
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.01284885
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.00974824
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98187152
69	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98174640
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98081019
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97865372
72	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.97141072
73	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.95221715
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95116044
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93469680
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93088943
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.92051672
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91772115
79	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91574833
80	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.91570900
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91407220
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91176874
83	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90451346
84	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.90383152
85	NCOR_22424771_ChIP-Seq_293T_Human	0.89909913
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89701676
87	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88867092
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88271254
89	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.87738182
90	TCF4_23295773_ChIP-Seq_U87_Human	0.87050911
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.85952183
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.85668555
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85668555
94	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.85454238
95	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.85411504
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84155570
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83774796
98	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.83303191
99	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.83071763
100	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.82762160

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.80072892
2	MP0006292_abnormal_olfactory_placode	4.19604977
3	MP0002822_catalepsy	4.08786621
4	MP0003011_delayed_dark_adaptation	3.89259843
5	MP0008877_abnormal_DNA_methylation	3.62580614
6	MP0003122_maternal_imprinting	3.53300066
7	MP0002102_abnormal_ear_morphology	3.36170932
8	MP0001188_hyperpigmentation	3.31947701
9	MP0003136_yellow_coat_color	3.29864210
10	MP0000569_abnormal_digit_pigmentation	2.96267510
11	MP0003123_paternal_imprinting	2.94389946
12	MP0002837_dystrophic_cardiac_calcinosis	2.77597857
13	MP0009379_abnormal_foot_pigmentation	2.71584569
14	MP0003121_genomic_imprinting	2.64027257
15	MP0005083_abnormal_biliary_tract	2.55742425
16	MP0001529_abnormal_vocalization	2.14897636
17	MP0008789_abnormal_olfactory_epithelium	2.14470091
18	MP0002653_abnormal_ependyma_morphology	2.10718221
19	MP0000778_abnormal_nervous_system	2.03852010
20	MP0004142_abnormal_muscle_tone	2.03733163
21	MP0006276_abnormal_autonomic_nervous	2.00262447
22	MP0005499_abnormal_olfactory_system	1.79873553
23	MP0005394_taste/olfaction_phenotype	1.79873553
24	MP0005409_darkened_coat_color	1.60599884
25	MP0004859_abnormal_synaptic_plasticity	1.60454086
26	MP0002734_abnormal_mechanical_nocicepti	1.58534111
27	MP0002638_abnormal_pupillary_reflex	1.49478171
28	MP0005084_abnormal_gallbladder_morpholo	1.44124242
29	MP0009840_abnormal_foam_cell	1.43589326
30	MP0005551_abnormal_eye_electrophysiolog	1.39716098
31	MP0001968_abnormal_touch/_nociception	1.39632136
32	MP0005423_abnormal_somatic_nervous	1.36309022
33	MP0003880_abnormal_central_pattern	1.36298961
34	MP0000955_abnormal_spinal_cord	1.34962496
35	MP0005174_abnormal_tail_pigmentation	1.34654791
36	MP0003879_abnormal_hair_cell	1.34168457
37	MP0002736_abnormal_nociception_after	1.29716483
38	MP0003635_abnormal_synaptic_transmissio	1.28224690
39	MP0005253_abnormal_eye_physiology	1.28205430
40	MP0001905_abnormal_dopamine_level	1.27424193
41	MP0002184_abnormal_innervation	1.27282152
42	MP0002272_abnormal_nervous_system	1.26099516
43	MP0003890_abnormal_embryonic-extraembry	1.23503736
44	MP0009745_abnormal_behavioral_response	1.18417013
45	MP0010386_abnormal_urinary_bladder	1.16164495
46	MP0001970_abnormal_pain_threshold	1.15610037
47	MP0002735_abnormal_chemical_nociception	1.15391537
48	MP0005646_abnormal_pituitary_gland	1.12982213
49	MP0004270_analgesia	1.12218139
50	MP0002557_abnormal_social/conspecific_i	1.12130747
51	MP0001324_abnormal_eye_pigmentation	1.11010669
52	MP0002063_abnormal_learning/memory/cond	1.09952466
53	MP0004924_abnormal_behavior	1.08311224
54	MP0005386_behavior/neurological_phenoty	1.08311224
55	MP0008058_abnormal_DNA_repair	1.05608556
56	MP0004811_abnormal_neuron_physiology	1.05406085
57	MP0002752_abnormal_somatic_nervous	1.04914845
58	MP0001986_abnormal_taste_sensitivity	1.04342321
59	MP0002938_white_spotting	1.04295570
60	MP0001485_abnormal_pinna_reflex	1.03096994
61	MP0001440_abnormal_grooming_behavior	1.02282527
62	MP0004019_abnormal_vitamin_homeostasis	0.99627089
63	MP0002733_abnormal_thermal_nociception	0.99085125
64	MP0001984_abnormal_olfaction	0.98253115
65	MP0000049_abnormal_middle_ear	0.97502297
66	MP0006072_abnormal_retinal_apoptosis	0.95440681
67	MP0002572_abnormal_emotion/affect_behav	0.94409510
68	MP0002882_abnormal_neuron_morphology	0.92793242
69	MP0001486_abnormal_startle_reflex	0.92073553
70	MP0002064_seizures	0.89838734
71	MP0005195_abnormal_posterior_eye	0.89308583
72	MP0003119_abnormal_digestive_system	0.87957423
73	MP0003186_abnormal_redox_activity	0.85058462
74	MP0004133_heterotaxia	0.84359336
75	MP0002152_abnormal_brain_morphology	0.81885934
76	MP0002909_abnormal_adrenal_gland	0.81760652
77	MP0000639_abnormal_adrenal_gland	0.80693737
78	MP0001293_anophthalmia	0.80674716
79	MP0004885_abnormal_endolymph	0.79296766
80	MP0003646_muscle_fatigue	0.78251906
81	MP0004145_abnormal_muscle_electrophysio	0.77545233
82	MP0003942_abnormal_urinary_system	0.77517042
83	MP0000230_abnormal_systemic_arterial	0.75255235
84	MP0002163_abnormal_gland_morphology	0.72849890
85	MP0009046_muscle_twitch	0.70561252
86	MP0002095_abnormal_skin_pigmentation	0.70269188
87	MP0004043_abnormal_pH_regulation	0.69638531
88	MP0000631_abnormal_neuroendocrine_gland	0.68636311
89	MP0002067_abnormal_sensory_capabilities	0.68603413
90	MP0004130_abnormal_muscle_cell	0.68210615
91	MP0001286_abnormal_eye_development	0.66451359
92	MP0002928_abnormal_bile_duct	0.66340214
93	MP0003567_abnormal_fetal_cardiomyocyte	0.64580303
94	MP0000534_abnormal_ureter_morphology	0.64158967
95	MP0005377_hearing/vestibular/ear_phenot	0.63916003
96	MP0003878_abnormal_ear_physiology	0.63916003
97	MP0003861_abnormal_nervous_system	0.62458024
98	MP0000427_abnormal_hair_cycle	0.61793847
99	MP0002229_neurodegeneration	0.61626074
100	MP0005391_vision/eye_phenotype	0.60812461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.62425369
2	Hepatoblastoma (HP:0002884)	4.01146458
3	Abnormality of DNA repair (HP:0003254)	3.65478305
4	Pancreatic fibrosis (HP:0100732)	3.65460836
5	Acute necrotizing encephalopathy (HP:0006965)	3.39116013
6	11 pairs of ribs (HP:0000878)	3.38447768
7	Entropion (HP:0000621)	3.28422831
8	Abnormal number of incisors (HP:0011064)	3.27074892
9	Urethral obstruction (HP:0000796)	3.23354902
10	Median cleft lip (HP:0000161)	3.18172253
11	Poikiloderma (HP:0001029)	3.15759448
12	Abnormality of midbrain morphology (HP:0002418)	3.13185638
13	Molar tooth sign on MRI (HP:0002419)	3.13185638
14	Nephrogenic diabetes insipidus (HP:0009806)	3.02802646
15	Polyphagia (HP:0002591)	2.99968288
16	Progressive macrocephaly (HP:0004481)	2.94608067
17	Medial flaring of the eyebrow (HP:0010747)	2.93858194
18	Abnormal pancreas size (HP:0012094)	2.93164938
19	Gait imbalance (HP:0002141)	2.90085022
20	Acute encephalopathy (HP:0006846)	2.79595757
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.71763400
22	Agitation (HP:0000713)	2.71362608
23	Supernumerary spleens (HP:0009799)	2.68625615
24	Macrocytic anemia (HP:0001972)	2.65434178
25	Myokymia (HP:0002411)	2.64023241
26	Congenital primary aphakia (HP:0007707)	2.61371032
27	Focal seizures (HP:0007359)	2.60486289
28	Pancreatic cysts (HP:0001737)	2.60286788
29	Colon cancer (HP:0003003)	2.60126330
30	Abnormality of magnesium homeostasis (HP:0004921)	2.48262383
31	Shawl scrotum (HP:0000049)	2.47540773
32	Anencephaly (HP:0002323)	2.37321649
33	Nephronophthisis (HP:0000090)	2.34726955
34	Submucous cleft hard palate (HP:0000176)	2.32551472
35	Poor coordination (HP:0002370)	2.31814932
36	Hyperthyroidism (HP:0000836)	2.30888185
37	True hermaphroditism (HP:0010459)	2.29915551
38	Abnormality of the labia minora (HP:0012880)	2.29385822
39	Metaphyseal dysplasia (HP:0100255)	2.28438054
40	Genital tract atresia (HP:0001827)	2.27515534
41	Long foot (HP:0001833)	2.26549816
42	Enlarged kidneys (HP:0000105)	2.24244219
43	Enlarged penis (HP:0000040)	2.24060792
44	Hip dysplasia (HP:0001385)	2.23543711
45	Oligodactyly (hands) (HP:0001180)	2.22852130
46	Abnormality of alanine metabolism (HP:0010916)	2.22520531
47	Hyperalaninemia (HP:0003348)	2.22520531
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22520531
49	Gaze-evoked nystagmus (HP:0000640)	2.21372127
50	Adrenal hypoplasia (HP:0000835)	2.20901312
51	Broad-based gait (HP:0002136)	2.20646925
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19272978
53	High anterior hairline (HP:0009890)	2.19037429
54	3-Methylglutaconic aciduria (HP:0003535)	2.13872235
55	Hyperventilation (HP:0002883)	2.12897203
56	Fibular hypoplasia (HP:0003038)	2.08474605
57	Dialeptic seizures (HP:0011146)	2.07733309
58	Postaxial hand polydactyly (HP:0001162)	2.07207373
59	CNS hypomyelination (HP:0003429)	2.06339270
60	Mitochondrial inheritance (HP:0001427)	2.06081123
61	Increased CSF lactate (HP:0002490)	2.05569421
62	Short tibia (HP:0005736)	2.05430207
63	Neonatal hypoglycemia (HP:0001998)	2.03876553
64	Gout (HP:0001997)	2.03276577
65	Abnormality of the corticospinal tract (HP:0002492)	2.03049413
66	Cerebral edema (HP:0002181)	2.02616518
67	Sclerocornea (HP:0000647)	2.00706874
68	Hydroureter (HP:0000072)	2.00387207
69	Limb dystonia (HP:0002451)	2.00311784
70	Double outlet right ventricle (HP:0001719)	1.99470261
71	Congenital malformation of the right heart (HP:0011723)	1.99470261
72	Status epilepticus (HP:0002133)	1.97637487
73	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92991527
74	Partial agenesis of the corpus callosum (HP:0001338)	1.91578386
75	Abnormality of the nasal septum (HP:0000419)	1.90594598
76	Abnormality of reticulocytes (HP:0004312)	1.90270517
77	Congenital stationary night blindness (HP:0007642)	1.89399542
78	Postaxial foot polydactyly (HP:0001830)	1.88420134
79	Vaginal atresia (HP:0000148)	1.88219006
80	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87833050
81	Decreased subcutaneous fat (HP:0001002)	1.87486227
82	X-linked dominant inheritance (HP:0001423)	1.85467907
83	Lissencephaly (HP:0001339)	1.84010713
84	Myotonia (HP:0002486)	1.81905915
85	Diastasis recti (HP:0001540)	1.81855432
86	Abnormal number of erythroid precursors (HP:0012131)	1.80895056
87	Hypogonadotrophic hypogonadism (HP:0000044)	1.80261256
88	Labial hypoplasia (HP:0000066)	1.78956185
89	Abnormality of the renal medulla (HP:0100957)	1.76491073
90	Left ventricular hypertrophy (HP:0001712)	1.76475169
91	Optic disc pallor (HP:0000543)	1.75569810
92	Missing ribs (HP:0000921)	1.75431839
93	Narrow forehead (HP:0000341)	1.75184947
94	Rib fusion (HP:0000902)	1.74555876
95	Erythroderma (HP:0001019)	1.73473978
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72082988
97	Epileptic encephalopathy (HP:0200134)	1.72039687
98	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.71533633
99	Polyuria (HP:0000103)	1.71355891
100	Irregular vertebral endplates (HP:0003301)	1.71225495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	8.60377842
2	CASK	3.76039387
3	PDK2	2.47762808
4	TNK2	2.38620172
5	PNCK	2.31733419
6	INSRR	2.30172518
7	WNK3	2.27883668
8	CDK19	2.23769918
9	MAP3K4	2.18429529
10	MARK1	2.18301773
11	EPHB2	2.09958465
12	WNK4	1.97640747
13	MKNK2	1.93044404
14	MAP3K9	1.90957306
15	MAP2K7	1.87240072
16	NUAK1	1.71998492
17	NTRK2	1.70118351
18	MAP2K4	1.62012043
19	FRK	1.57945426
20	DMPK	1.56044719
21	NTRK3	1.47453230
22	MARK2	1.34771892
23	MINK1	1.30542226
24	MAPK13	1.21862603
25	DYRK2	1.20710027
26	PINK1	1.17227037
27	PRKCG	1.15130261
28	CAMK1G	1.14776159
29	MKNK1	1.05096793
30	ILK	1.03785408
31	OXSR1	1.01264208
32	DYRK3	0.95364261
33	TYRO3	0.93065741
34	TAOK3	0.91539760
35	ACVR1B	0.91283632
36	STK39	0.91204371
37	CAMK1	0.89280473
38	PHKG2	0.89245401
39	PHKG1	0.89245401
40	STK11	0.87658777
41	GRK1	0.87539870
42	ADRBK2	0.85948748
43	BTK	0.84113139
44	RPS6KA2	0.82926416
45	STK38	0.78826187
46	CSNK1E	0.75440169
47	SGK494	0.72008783
48	SGK223	0.72008783
49	PRKCZ	0.69349561
50	PAK3	0.67134796
51	PRKCQ	0.62711797
52	SGK2	0.61690976
53	RAF1	0.61448193
54	MAP3K6	0.60104386
55	TRIM28	0.57784315
56	NTRK1	0.57348965
57	PRKACA	0.57203990
58	TLK1	0.54465075
59	PIM2	0.53320014
60	ZAK	0.53110547
61	LIMK1	0.50942636
62	PRKDC	0.50652481
63	SGK1	0.48631663
64	BCKDK	0.48567903
65	PAK6	0.44703500
66	MAPK14	0.43623915
67	PLK2	0.43601755
68	CAMK1D	0.43326323
69	PRKG1	0.43258566
70	CSNK1A1	0.43229055
71	PRKD3	0.43000352
72	BMPR1B	0.42834034
73	ATR	0.41791078
74	RPS6KA6	0.41142926
75	CDK5	0.40239895
76	WNK1	0.38925161
77	CAMKK1	0.38166267
78	CAMK2A	0.36431090
79	FGFR2	0.35879575
80	VRK1	0.35136454
81	CSNK2A2	0.35133714
82	CDK14	0.34706659
83	ATM	0.34235460
84	CAMK2D	0.33824742
85	TGFBR1	0.32369205
86	CSNK1G2	0.32047455
87	OBSCN	0.31523732
88	CSNK1D	0.31155938
89	LRRK2	0.30878141
90	PRKCI	0.30699209
91	MAPK12	0.30458891
92	TAOK1	0.30155200
93	PRKCB	0.30137550
94	PRKACB	0.29496589
95	TIE1	0.29025644
96	PIK3CA	0.28849175
97	CDK15	0.27910557
98	CAMK2G	0.27785366
99	RPS6KA3	0.27659496
100	PRKCA	0.27553435

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.65905531
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65760951
3	Parkinsons disease_Homo sapiens_hsa05012	3.42425468
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.41925935
5	Huntingtons disease_Homo sapiens_hsa05016	2.50292670
6	Nicotine addiction_Homo sapiens_hsa05033	2.49924736
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.45950535
8	Protein export_Homo sapiens_hsa03060	2.44016643
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.43002278
10	Basal transcription factors_Homo sapiens_hsa03022	2.27718345
11	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.21128370
12	Nucleotide excision repair_Homo sapiens_hsa03420	1.94560570
13	Alzheimers disease_Homo sapiens_hsa05010	1.94531465
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92978567
15	Butanoate metabolism_Homo sapiens_hsa00650	1.74652857
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.73927777
17	Insulin secretion_Homo sapiens_hsa04911	1.70048675
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.65900979
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.61422268
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.59372006
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.58604137
22	Dopaminergic synapse_Homo sapiens_hsa04728	1.53583416
23	Mismatch repair_Homo sapiens_hsa03430	1.52600839
24	Propanoate metabolism_Homo sapiens_hsa00640	1.50265563
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.46525437
26	Circadian entrainment_Homo sapiens_hsa04713	1.46426232
27	GABAergic synapse_Homo sapiens_hsa04727	1.40727641
28	Cocaine addiction_Homo sapiens_hsa05030	1.39140039
29	Retinol metabolism_Homo sapiens_hsa00830	1.38367336
30	Morphine addiction_Homo sapiens_hsa05032	1.35286517
31	Phototransduction_Homo sapiens_hsa04744	1.35149557
32	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.34815025
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30725644
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.16036522
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15908662
36	Axon guidance_Homo sapiens_hsa04360	1.07836261
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07797473
38	Cholinergic synapse_Homo sapiens_hsa04725	1.05099608
39	Fatty acid elongation_Homo sapiens_hsa00062	1.03415010
40	RNA polymerase_Homo sapiens_hsa03020	1.02774306
41	Fatty acid degradation_Homo sapiens_hsa00071	0.97864706
42	Homologous recombination_Homo sapiens_hsa03440	0.96918599
43	Olfactory transduction_Homo sapiens_hsa04740	0.92632872
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.91365051
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90707798
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88285092
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86315089
48	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.85995828
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85135273
50	Peroxisome_Homo sapiens_hsa04146	0.84839807
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84767096
52	Serotonergic synapse_Homo sapiens_hsa04726	0.83260401
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82955992
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.79393128
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.77360000
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.75385862
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.70795079
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.70417810
59	Long-term depression_Homo sapiens_hsa04730	0.66071347
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65988907
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64637307
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63974058
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63574610
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62336465
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60299512
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60222188
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59685579
68	Metabolic pathways_Homo sapiens_hsa01100	0.59175950
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59005621
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58220791
71	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.57273750
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55910351
73	Gastric acid secretion_Homo sapiens_hsa04971	0.55518586
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.55138160
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54920488
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.54774696
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53782477
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53655462
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.53563610
80	RNA degradation_Homo sapiens_hsa03018	0.49711837
81	Amphetamine addiction_Homo sapiens_hsa05031	0.48426552
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47572490
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.46758759
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.45892584
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.45507941
86	Bile secretion_Homo sapiens_hsa04976	0.44870942
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.43766019
88	Tight junction_Homo sapiens_hsa04530	0.43401136
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42447822
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40964647
91	Alcoholism_Homo sapiens_hsa05034	0.37222950
92	Taste transduction_Homo sapiens_hsa04742	0.35414513
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35383706
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34693236
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.31312435
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.31215329
97	RNA transport_Homo sapiens_hsa03013	0.30684197
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29358628
99	Renin secretion_Homo sapiens_hsa04924	0.29220274
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28935578

ZNF652P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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