ZNF653

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.00570353
2regulation of early endosome to late endosome transport (GO:2000641)3.98311683
3mannose metabolic process (GO:0006013)3.96008092
4protein localization to endosome (GO:0036010)3.84279072
5modulation by virus of host process (GO:0019054)3.80481832
6regulation of mammary gland epithelial cell proliferation (GO:0033599)3.79456232
7modulation by symbiont of host cellular process (GO:0044068)3.76748122
8cell-cell junction maintenance (GO:0045217)3.74044429
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.72855112
10adenosine receptor signaling pathway (GO:0001973)3.66298884
11protein retention in ER lumen (GO:0006621)3.60146150
12GDP-mannose metabolic process (GO:0019673)3.56660485
13regulation of NFAT protein import into nucleus (GO:0051532)3.54492668
14cell migration in hindbrain (GO:0021535)3.51856704
15positive regulation of histone deacetylation (GO:0031065)3.48046533
16negative regulation of cell size (GO:0045792)3.47961623
17regulation of ARF GTPase activity (GO:0032312)3.40897057
18positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.39414897
19sensory perception of taste (GO:0050909)3.38584848
20apoptotic process involved in morphogenesis (GO:0060561)3.31125219
21regulation of ARF protein signal transduction (GO:0032012)3.27748216
22stress fiber assembly (GO:0043149)3.25812486
23UV protection (GO:0009650)3.20046972
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16028773
25NIK/NF-kappaB signaling (GO:0038061)3.15984034
26modulation by virus of host morphology or physiology (GO:0019048)3.15077785
27cellular response to virus (GO:0098586)3.12143904
28positive regulation of Cdc42 GTPase activity (GO:0043089)3.11710664
29semaphorin-plexin signaling pathway (GO:0071526)3.09787796
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06351284
31activation of MAPKKK activity (GO:0000185)3.05155979
32regulation of chromatin binding (GO:0035561)2.98883094
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87559028
34histone H4 deacetylation (GO:0070933)2.85450588
35positive regulation of protein deacetylation (GO:0090312)2.85056147
36activation of JUN kinase activity (GO:0007257)2.82349674
37negative regulation of cAMP-mediated signaling (GO:0043951)2.81409419
38receptor catabolic process (GO:0032801)2.79992925
39histone H3-K4 trimethylation (GO:0080182)2.79268278
40thymic T cell selection (GO:0045061)2.79104961
41peptidyl-tyrosine autophosphorylation (GO:0038083)2.77936657
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77354830
43positive regulation by organism of defense response of other organism involved in symbiotic interact2.77354830
44modulation by symbiont of host immune response (GO:0052553)2.77354830
45positive regulation by symbiont of host defense response (GO:0052509)2.77354830
46modulation by symbiont of host defense response (GO:0052031)2.77354830
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77354830
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77173161
49intracellular estrogen receptor signaling pathway (GO:0030520)2.75061724
50activation of Rac GTPase activity (GO:0032863)2.70642711
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70238944
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70060259
53mitochondrion transport along microtubule (GO:0047497)2.70060259
54positive thymic T cell selection (GO:0045059)2.69544780
55response to muramyl dipeptide (GO:0032495)2.69213064
56protein insertion into membrane (GO:0051205)2.69031379
57ribosomal small subunit biogenesis (GO:0042274)2.64910530
58positive regulation of T cell apoptotic process (GO:0070234)2.63972652
59response to parathyroid hormone (GO:0071107)2.62687277
60positive regulation of protein kinase C signaling (GO:0090037)2.62262922
61response to peptidoglycan (GO:0032494)2.58183534
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.57955248
63peptidyl-arginine omega-N-methylation (GO:0035247)2.57108328
64regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.56003750
65regulation of glycogen (starch) synthase activity (GO:2000465)2.54841735
66histone H2B ubiquitination (GO:0033523)2.54327017
67regulation of interferon-beta biosynthetic process (GO:0045357)2.52558887
68negative regulation of glial cell proliferation (GO:0060253)2.50132439
69signal complex assembly (GO:0007172)2.50061213
70cell junction maintenance (GO:0034331)2.49331661
713-UTR-mediated mRNA stabilization (GO:0070935)2.48255543
72positive regulation of synapse maturation (GO:0090129)2.47644802
73regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.47289581
74positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.47289581
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47283475
76actin filament bundle assembly (GO:0051017)2.45731450
77actin filament bundle organization (GO:0061572)2.45731450
78positive regulation of lymphocyte apoptotic process (GO:0070230)2.43909587
79response to laminar fluid shear stress (GO:0034616)2.43858209
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42541013
81positive regulation of CREB transcription factor activity (GO:0032793)2.42220453
82regulation of monocyte differentiation (GO:0045655)2.42143637
83establishment of mitochondrion localization (GO:0051654)2.40840427
84dopamine receptor signaling pathway (GO:0007212)2.40571865
85planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39247741
86positive regulation of Rap GTPase activity (GO:0032854)2.38781070
87erythrocyte development (GO:0048821)2.37170525
88positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.35408774
89apoptotic process involved in development (GO:1902742)2.30253108
90layer formation in cerebral cortex (GO:0021819)2.29856183
91negative regulation of viral release from host cell (GO:1902187)2.29216394
92intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.28916437
93glycine transport (GO:0015816)2.28859234
94G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.28844521
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.28791764
96positive regulation of protein dephosphorylation (GO:0035307)2.27694195
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.27684477
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.27637813
99regulation of synapse structural plasticity (GO:0051823)2.25981430
100modification by symbiont of host morphology or physiology (GO:0044003)2.25448023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.49943569
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25474156
3* LXR_22292898_ChIP-Seq_THP-1_Human3.19893188
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76645212
5MYC_22102868_ChIP-Seq_BL_Human2.75726585
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62983143
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61547018
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.50831539
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37697139
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36730832
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.30782113
12KDM2B_26808549_Chip-Seq_DND41_Human2.30161256
13P68_20966046_ChIP-Seq_HELA_Human2.22632068
14* RACK7_27058665_Chip-Seq_MCF-7_Human2.09579733
15TCF7_22412390_ChIP-Seq_EML_Mouse2.07504198
16KDM2B_26808549_Chip-Seq_K562_Human2.01643118
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.96584710
18TET1_21451524_ChIP-Seq_MESCs_Mouse1.89176744
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.86551416
20* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77415399
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75293699
22MAF_26560356_Chip-Seq_TH2_Human1.74591970
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74425590
24VDR_24763502_ChIP-Seq_THP-1_Human1.73226289
25* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73054871
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71981352
27SA1_27219007_Chip-Seq_ERYTHROID_Human1.71303417
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71293080
29SMC4_20622854_ChIP-Seq_HELA_Human1.70940971
30MAF_26560356_Chip-Seq_TH1_Human1.70497825
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.66388577
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65874046
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.65107207
34* BCL6_27268052_Chip-Seq_Bcells_Human1.63330180
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59753828
36CTCF_27219007_Chip-Seq_Bcells_Human1.59241670
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56838488
38BCOR_27268052_Chip-Seq_Bcells_Human1.56729682
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56633939
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53931366
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52531901
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51648598
43* CREB1_26743006_Chip-Seq_LNCaP_Human1.51061303
44* UTX_26944678_Chip-Seq_JUKART_Human1.46908876
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43005991
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42876954
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42036548
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39460016
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37131448
50TP53_22127205_ChIP-Seq_IMR90_Human1.36733581
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36319231
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34194508
53MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33423433
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32462892
55* E2F1_20622854_ChIP-Seq_HELA_Human1.32129407
56PHF8_20622854_ChIP-Seq_HELA_Human1.30529408
57NCOR1_26117541_ChIP-Seq_K562_Human1.29111832
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28024448
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27026931
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26101660
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25307844
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.22879345
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22115555
64CTCF_21964334_Chip-Seq_Bcells_Human1.21096327
65ATF3_27146783_Chip-Seq_COLON_Human1.19676762
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19572202
67CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18901089
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18359888
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17380631
70RARA_24833708_ChIP-Seq_LIVER_Mouse1.16994883
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16371151
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16205780
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15759477
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15127121
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.14963669
76* XRN2_22483619_ChIP-Seq_HELA_Human1.14140795
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.14114285
78SA1_27219007_Chip-Seq_Bcells_Human1.13133491
79RARB_24833708_ChIP-Seq_LIVER_Mouse1.12552381
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12452535
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12236445
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07978715
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07441705
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06871849
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.05224642
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05031764
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.03988673
88GATA1_19941826_ChIP-Seq_K562_Human1.03942697
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03088038
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.02559348
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.02308381
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.02106958
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01524456
94TP63_22573176_ChIP-Seq_HFKS_Human1.01048442
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00293455
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99749515
97CTCF_20526341_ChIP-Seq_ESCs_Human0.97553888
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97331909
99SCL_19346495_ChIP-Seq_HPC-7_Human0.97119027
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95784742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.21033338
2MP0005451_abnormal_body_composition3.20138320
3MP0001986_abnormal_taste_sensitivity3.05855911
4MP0003303_peritoneal_inflammation3.02091715
5MP0001348_abnormal_lacrimal_gland2.90453229
6MP0005058_abnormal_lysosome_morphology2.60433145
7MP0005423_abnormal_somatic_nervous2.59523378
8MP0003172_abnormal_lysosome_physiology2.58788679
9MP0004859_abnormal_synaptic_plasticity2.58401946
10MP0004185_abnormal_adipocyte_glucose2.56774928
11MP0003123_paternal_imprinting2.48143637
12MP0005076_abnormal_cell_differentiation2.47140192
13MP0003329_amyloid_beta_deposits2.46532927
14MP0003436_decreased_susceptibility_to2.43352716
15MP0005409_darkened_coat_color2.21620433
16MP0002089_abnormal_postnatal_growth/wei2.14431422
17MP0000678_abnormal_parathyroid_gland2.04266601
18MP0003453_abnormal_keratinocyte_physiol2.03919551
19MP0004858_abnormal_nervous_system2.02879910
20MP0004510_myositis1.91536435
21MP0009278_abnormal_bone_marrow1.84289501
22MP0005666_abnormal_adipose_tissue1.76315667
23MP0008260_abnormal_autophagy1.76227297
24MP0001188_hyperpigmentation1.74634758
25MP0009333_abnormal_splenocyte_physiolog1.72207053
26MP0002249_abnormal_larynx_morphology1.71883432
27MP0005083_abnormal_biliary_tract1.65187892
28MP0002822_catalepsy1.64011573
29MP0003879_abnormal_hair_cell1.62471059
30MP0009840_abnormal_foam_cell1.56629854
31MP0003656_abnormal_erythrocyte_physiolo1.51631683
32MP0004130_abnormal_muscle_cell1.51195335
33MP0005375_adipose_tissue_phenotype1.49701244
34MP0000003_abnormal_adipose_tissue1.48105163
35MP0003693_abnormal_embryo_hatching1.46316604
36MP0004947_skin_inflammation1.45328487
37MP0009053_abnormal_anal_canal1.42602781
38MP0000604_amyloidosis1.39796979
39MP0000685_abnormal_immune_system1.36128649
40MP0005377_hearing/vestibular/ear_phenot1.32371392
41MP0003878_abnormal_ear_physiology1.32371392
42MP0001849_ear_inflammation1.29758813
43MP0005025_abnormal_response_to1.26140310
44MP0001346_abnormal_lacrimal_gland1.25047746
45MP0008874_decreased_physiological_sensi1.20446162
46MP0003183_abnormal_peptide_metabolism1.10743731
47MP0000681_abnormal_thyroid_gland1.10636292
48MP0003634_abnormal_glial_cell1.07182409
49MP0003763_abnormal_thymus_physiology1.04754826
50MP0003300_gastrointestinal_ulcer1.04628325
51MP0005000_abnormal_immune_tolerance1.02155952
52MP0005310_abnormal_salivary_gland1.01770369
53MP0004381_abnormal_hair_follicle1.00026741
54MP0000015_abnormal_ear_pigmentation0.99516376
55MP0003136_yellow_coat_color0.98918225
56MP0002735_abnormal_chemical_nociception0.98354760
57MP0002398_abnormal_bone_marrow0.96489585
58MP0003091_abnormal_cell_migration0.95962715
59MP0003787_abnormal_imprinting0.95760038
60MP0002063_abnormal_learning/memory/cond0.95177477
61MP0001545_abnormal_hematopoietic_system0.94568705
62MP0005397_hematopoietic_system_phenotyp0.94568705
63MP0002419_abnormal_innate_immunity0.93872549
64MP0001790_abnormal_immune_system0.91537820
65MP0005387_immune_system_phenotype0.91537820
66MP0002877_abnormal_melanocyte_morpholog0.90998364
67MP0005501_abnormal_skin_physiology0.90712894
68MP0001968_abnormal_touch/_nociception0.90118030
69MP0002420_abnormal_adaptive_immunity0.88756209
70MP0000703_abnormal_thymus_morphology0.87264062
71MP0001819_abnormal_immune_cell0.86684702
72MP0001958_emphysema0.83883099
73MP0001873_stomach_inflammation0.83184835
74MP0000858_altered_metastatic_potential0.81485501
75MP0003635_abnormal_synaptic_transmissio0.81445416
76MP0000733_abnormal_muscle_development0.81206099
77MP0000750_abnormal_muscle_regeneration0.81082676
78MP0002723_abnormal_immune_serum0.80816039
79MP0002429_abnormal_blood_cell0.80467579
80MP0003075_altered_response_to0.77893200
81MP0004811_abnormal_neuron_physiology0.76630083
82MP0000716_abnormal_immune_system0.76140264
83MP0004233_abnormal_muscle_weight0.75872066
84MP0000313_abnormal_cell_death0.74498582
85MP0009931_abnormal_skin_appearance0.72913807
86MP0002653_abnormal_ependyma_morphology0.72753385
87MP0001502_abnormal_circadian_rhythm0.72006269
88MP0001730_embryonic_growth_arrest0.71928724
89MP0005464_abnormal_platelet_physiology0.71327934
90MP0002452_abnormal_antigen_presenting0.70786328
91MP0001800_abnormal_humoral_immune0.70532748
92MP0001663_abnormal_digestive_system0.69396874
93MP0003866_abnormal_defecation0.69231473
94MP0002722_abnormal_immune_system0.69001681
95MP0002405_respiratory_system_inflammati0.67448077
96MP0001970_abnormal_pain_threshold0.64806568
97MP0000343_altered_response_to0.64154529
98MP0000955_abnormal_spinal_cord0.62621971
99MP0002163_abnormal_gland_morphology0.62193214
100MP0002998_abnormal_bone_remodeling0.60732835

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)3.99931140
2Long palpebral fissure (HP:0000637)3.90952351
3Ulnar bowing (HP:0003031)3.70438544
4Abnormality of the thoracic spine (HP:0100711)3.27956906
5Annular pancreas (HP:0001734)3.22577987
6Thoracic kyphosis (HP:0002942)3.20955802
7Hyperacusis (HP:0010780)3.08448977
8Obstructive sleep apnea (HP:0002870)3.07192155
9Hyperthyroidism (HP:0000836)3.00705443
10Thin bony cortex (HP:0002753)2.88360990
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.74726230
12Cerebral aneurysm (HP:0004944)2.61698772
13Reticulocytosis (HP:0001923)2.61148744
14Hemorrhage of the eye (HP:0011885)2.60329933
15Insomnia (HP:0100785)2.57575080
16Upper limb amyotrophy (HP:0009129)2.56998601
17Distal upper limb amyotrophy (HP:0007149)2.56998601
18Upper motor neuron abnormality (HP:0002127)2.52330949
19Abnormality of the fingertips (HP:0001211)2.50328983
20Turricephaly (HP:0000262)2.47185436
21Cerebral inclusion bodies (HP:0100314)2.46040437
22Rectal prolapse (HP:0002035)2.45333814
23Abnormality of the aortic arch (HP:0012303)2.42819346
24Supranuclear gaze palsy (HP:0000605)2.42069480
25Hypertensive crisis (HP:0100735)2.32428464
26Bowing of the arm (HP:0006488)2.30535462
27Bowed forearm bones (HP:0003956)2.30535462
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27895346
29Hypercortisolism (HP:0001578)2.26868413
30Achilles tendon contracture (HP:0001771)2.26488091
31Hand muscle atrophy (HP:0009130)2.21224339
32Cellulitis (HP:0100658)2.17203187
33Mitral regurgitation (HP:0001653)2.13216878
34Broad distal phalanx of finger (HP:0009836)2.06409029
35Short nail (HP:0001799)2.06324942
36Neuronal loss in central nervous system (HP:0002529)2.05080934
37Genu recurvatum (HP:0002816)2.03478290
38Hyperparathyroidism (HP:0000843)2.02630245
39Easy fatigability (HP:0003388)2.01725885
40Neurofibrillary tangles (HP:0002185)1.99928839
41Cholelithiasis (HP:0001081)1.98464654
42Rib fusion (HP:0000902)1.97876658
43Dysostosis multiplex (HP:0000943)1.97448644
44Myopathic facies (HP:0002058)1.95860392
45Testicular atrophy (HP:0000029)1.95341436
46J-shaped sella turcica (HP:0002680)1.94787372
47Increased cerebral lipofuscin (HP:0011813)1.94693777
48Atelectasis (HP:0100750)1.94170259
49Abnormal gallbladder physiology (HP:0012438)1.93859850
50Cholecystitis (HP:0001082)1.93859850
51Gastrointestinal infarctions (HP:0005244)1.93519349
52Pointed chin (HP:0000307)1.92018012
53Distal lower limb amyotrophy (HP:0008944)1.91925585
54Abnormality of the Achilles tendon (HP:0005109)1.91430051
55Disproportionate tall stature (HP:0001519)1.90254966
56Germ cell neoplasia (HP:0100728)1.90235191
57Emphysema (HP:0002097)1.88715368
58Myokymia (HP:0002411)1.87938095
59Depression (HP:0000716)1.86764968
60Nasal polyposis (HP:0100582)1.85987280
61Generalized hyperpigmentation (HP:0007440)1.85393449
62Hypochromic anemia (HP:0001931)1.82785363
63Thickened helices (HP:0000391)1.82372480
64Abnormality of the gallbladder (HP:0005264)1.81551342
65Visual hallucinations (HP:0002367)1.81520440
66Obstructive lung disease (HP:0006536)1.81282910
67Chronic obstructive pulmonary disease (HP:0006510)1.81282910
68Colitis (HP:0002583)1.80652410
69Truncus arteriosus (HP:0001660)1.80098120
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79182727
71Vertebral compression fractures (HP:0002953)1.78397545
72Vertebral arch anomaly (HP:0008438)1.76984809
73Stridor (HP:0010307)1.75964490
74Abnormality of polysaccharide metabolism (HP:0011012)1.75696738
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75696738
76Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75696738
77Mucopolysacchariduria (HP:0008155)1.74903117
78Urinary glycosaminoglycan excretion (HP:0003541)1.74903117
79Abnormality of the nasal mucosa (HP:0000433)1.74413571
80Spinal canal stenosis (HP:0003416)1.73505245
81Squamous cell carcinoma (HP:0002860)1.73126798
82Thin ribs (HP:0000883)1.71232378
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70303734
84Increased neuronal autofluorescent lipopigment (HP:0002074)1.70148270
85Broad face (HP:0000283)1.69811327
86Abnormality of the heme biosynthetic pathway (HP:0010472)1.69707588
87Abnormality of reticulocytes (HP:0004312)1.69507911
88Absent epiphyses (HP:0010577)1.68677961
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68677961
90Abnormality of macrophages (HP:0004311)1.68591481
91Increased serum ferritin (HP:0003281)1.68416319
92Purpura (HP:0000979)1.67748777
93Sparse lateral eyebrow (HP:0005338)1.67532161
94Precocious puberty (HP:0000826)1.67401590
95Eczematoid dermatitis (HP:0000976)1.66809379
96Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66357090
97Ankle clonus (HP:0011448)1.65344053
98Prolonged neonatal jaundice (HP:0006579)1.64813068
99Polygenic inheritance (HP:0010982)1.58272742
100Short femoral neck (HP:0100864)1.58104552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.05937079
2TRIB34.01220595
3SMG13.24216054
4ICK3.20243910
5PRPF4B3.19476778
6SIK12.56468700
7EEF2K2.54979751
8IRAK32.28111147
9BRAF2.25694218
10ARAF2.12828303
11ERN12.03859958
12NME22.01061856
13MAP3K112.00448103
14SIK21.80815475
15CDK121.72572167
16TAOK11.64294149
17MAP2K31.57498329
18TAOK21.56676561
19MAP3K131.56020204
20MAPK151.52571942
21PRKD31.49405724
22RIPK41.47147476
23MAP3K101.42908783
24MARK21.41220103
25RPS6KA21.38769135
26TAF11.29606660
27KSR21.26450826
28RIPK11.22283098
29MARK11.21168669
30MAP4K11.21053161
31DDR21.07684828
32TYRO31.07387477
33RPS6KC11.05727760
34RPS6KL11.05727760
35PDPK11.05000722
36PIM21.04831484
37BLK1.03959899
38TESK11.02932887
39MAP2K21.00187143
40CDC42BPA0.99194818
41PRKD20.95346055
42TESK20.91128500
43CAMKK10.90372511
44MAP3K10.89424137
45TNK20.86252986
46RPS6KA60.86093487
47AURKA0.85136513
48IRAK20.81737458
49PKN20.81333371
50GRK60.80838661
51MTOR0.79850019
52CAMK1D0.77582050
53DYRK1B0.76173274
54MAP3K80.74746404
55WNK40.74641267
56MAP3K30.74498656
57SIK30.73660902
58CAMK1G0.73307618
59MAPK120.70918379
60HIPK20.69866627
61TBK10.69768691
62IRAK40.68718996
63LRRK20.68628012
64TTN0.66865671
65MAPK110.66394615
66LATS20.64114588
67CSK0.62905068
68MOS0.62215911
69PDK10.61656252
70SGK30.60144537
71STK160.56989811
72CDK11A0.56588204
73STK110.55716664
74ZAP700.54488928
75WNK10.53356722
76DAPK30.53165815
77CDK150.49156047
78PAK60.48745310
79BMX0.46632488
80RPS6KA10.45319486
81CDK40.44068045
82MAPK40.43737765
83RAF10.43630794
84NTRK10.43548733
85PRKCH0.43331355
86CDK70.41720309
87CDK180.39444805
88EPHA20.39034005
89KSR10.37934880
90SGK4940.37629922
91SGK2230.37629922
92CDK140.36380925
93PAK10.36298398
94CDK50.36013694
95RPS6KB20.34729383
96AKT20.34241455
97MAPK80.34149410
98PDGFRA0.33873378
99TYK20.32976999
100FGFR40.32239071

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.97018532
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.37251454
3VEGF signaling pathway_Homo sapiens_hsa043702.24717003
4Bladder cancer_Homo sapiens_hsa052192.17424354
5B cell receptor signaling pathway_Homo sapiens_hsa046622.06052735
6Acute myeloid leukemia_Homo sapiens_hsa052211.98717797
7Notch signaling pathway_Homo sapiens_hsa043301.98530743
8Non-small cell lung cancer_Homo sapiens_hsa052231.92270278
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84395671
10Chronic myeloid leukemia_Homo sapiens_hsa052201.84047510
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.79582621
12Other glycan degradation_Homo sapiens_hsa005111.77809726
13Neurotrophin signaling pathway_Homo sapiens_hsa047221.69858860
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62068142
15Endometrial cancer_Homo sapiens_hsa052131.58027093
16Prion diseases_Homo sapiens_hsa050201.55094000
17mTOR signaling pathway_Homo sapiens_hsa041501.50251120
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48504905
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40869946
20ErbB signaling pathway_Homo sapiens_hsa040121.40096478
21Glioma_Homo sapiens_hsa052141.37674783
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33777686
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32764734
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31284194
25Pancreatic cancer_Homo sapiens_hsa052121.30456542
26Osteoclast differentiation_Homo sapiens_hsa043801.30342542
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30108759
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24799225
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.22829403
30Long-term potentiation_Homo sapiens_hsa047201.19744637
31GnRH signaling pathway_Homo sapiens_hsa049121.18535812
32Fructose and mannose metabolism_Homo sapiens_hsa000511.15433643
33Insulin signaling pathway_Homo sapiens_hsa049101.11094775
34Apoptosis_Homo sapiens_hsa042101.10731438
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.10668317
36Prolactin signaling pathway_Homo sapiens_hsa049171.09491517
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08778370
38T cell receptor signaling pathway_Homo sapiens_hsa046601.05428515
39Renal cell carcinoma_Homo sapiens_hsa052111.01761795
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.00915888
41Hepatitis B_Homo sapiens_hsa051611.00450063
42Synaptic vesicle cycle_Homo sapiens_hsa047211.00113567
43Thyroid cancer_Homo sapiens_hsa052160.99093232
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98107752
45MAPK signaling pathway_Homo sapiens_hsa040100.97921644
46Hepatitis C_Homo sapiens_hsa051600.97516113
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.94351844
48Influenza A_Homo sapiens_hsa051640.94153143
49Estrogen signaling pathway_Homo sapiens_hsa049150.93362965
50Endocytosis_Homo sapiens_hsa041440.92747010
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.92459380
52Leishmaniasis_Homo sapiens_hsa051400.91367358
53Tuberculosis_Homo sapiens_hsa051520.90649107
54Colorectal cancer_Homo sapiens_hsa052100.88566208
55Lysosome_Homo sapiens_hsa041420.87142244
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86494216
57AMPK signaling pathway_Homo sapiens_hsa041520.86238014
58TNF signaling pathway_Homo sapiens_hsa046680.86089637
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.83348360
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82324297
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81094885
62Melanogenesis_Homo sapiens_hsa049160.79238918
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76417106
64Inositol phosphate metabolism_Homo sapiens_hsa005620.75000081
65Toxoplasmosis_Homo sapiens_hsa051450.73741381
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73290354
67Viral carcinogenesis_Homo sapiens_hsa052030.72818249
68Prostate cancer_Homo sapiens_hsa052150.72003503
69Insulin resistance_Homo sapiens_hsa049310.70957393
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.69939192
71Choline metabolism in cancer_Homo sapiens_hsa052310.69753732
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69317400
73HTLV-I infection_Homo sapiens_hsa051660.67138571
74Salmonella infection_Homo sapiens_hsa051320.66652750
75Chemokine signaling pathway_Homo sapiens_hsa040620.64224083
76Herpes simplex infection_Homo sapiens_hsa051680.64075953
77Type II diabetes mellitus_Homo sapiens_hsa049300.63321100
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62146719
79Alcoholism_Homo sapiens_hsa050340.61293067
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59764170
81Axon guidance_Homo sapiens_hsa043600.59451947
82Cholinergic synapse_Homo sapiens_hsa047250.58741585
83Malaria_Homo sapiens_hsa051440.57317079
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56845131
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56445529
86Epstein-Barr virus infection_Homo sapiens_hsa051690.55637360
87Oxytocin signaling pathway_Homo sapiens_hsa049210.55626010
88Gap junction_Homo sapiens_hsa045400.54616943
89Cocaine addiction_Homo sapiens_hsa050300.52952167
90FoxO signaling pathway_Homo sapiens_hsa040680.51155820
91Rap1 signaling pathway_Homo sapiens_hsa040150.50966622
92Measles_Homo sapiens_hsa051620.50313607
93Proteoglycans in cancer_Homo sapiens_hsa052050.49882666
94MicroRNAs in cancer_Homo sapiens_hsa052060.46866419
95Vibrio cholerae infection_Homo sapiens_hsa051100.46721572
96HIF-1 signaling pathway_Homo sapiens_hsa040660.46591672
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45009680
98Sphingolipid metabolism_Homo sapiens_hsa006000.44679453
99Galactose metabolism_Homo sapiens_hsa000520.43708478
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43697679

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