ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.89091263
2	regulation of meiosis I (GO:0060631)	5.92719729
3	monoubiquitinated protein deubiquitination (GO:0035520)	4.96035422
4	synapsis (GO:0007129)	4.93137476
5	DNA methylation involved in gamete generation (GO:0043046)	4.44489067
6	neural tube formation (GO:0001841)	4.41610513
7	mitotic sister chromatid cohesion (GO:0007064)	4.40256563
8	attachment of spindle microtubules to kinetochore (GO:0008608)	4.34938166
9	male meiosis (GO:0007140)	4.20303294
10	protein K11-linked deubiquitination (GO:0035871)	3.94584118
11	sister chromatid cohesion (GO:0007062)	3.87741255
12	pyrimidine dimer repair (GO:0006290)	3.83519945
13	centriole replication (GO:0007099)	3.74533973
14	gene silencing by RNA (GO:0031047)	3.73700421
15	male meiosis I (GO:0007141)	3.64140781
16	establishment of protein localization to Golgi (GO:0072600)	3.61532341
17	negative regulation of meiosis (GO:0045835)	3.51893618
18	histone mRNA catabolic process (GO:0071044)	3.49723050
19	microtubule anchoring (GO:0034453)	3.46796831
20	protein targeting to Golgi (GO:0000042)	3.44526865
21	protein K48-linked deubiquitination (GO:0071108)	3.44102374
22	regulation of centriole replication (GO:0046599)	3.43343392
23	chromosome organization involved in meiosis (GO:0070192)	3.39982763
24	meiotic nuclear division (GO:0007126)	3.34790336
25	regulation of DNA endoreduplication (GO:0032875)	3.29969901
26	positive regulation of male gonad development (GO:2000020)	3.29803968
27	germ cell migration (GO:0008354)	3.24786218
28	resolution of meiotic recombination intermediates (GO:0000712)	3.23843445
29	meiotic cell cycle (GO:0051321)	3.19488347
30	negative regulation of meiotic cell cycle (GO:0051447)	3.18059434
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.16242226
32	interkinetic nuclear migration (GO:0022027)	3.14441325
33	cellular response to ethanol (GO:0071361)	3.09922314
34	regulation of fibroblast apoptotic process (GO:2000269)	3.08658597
35	meiotic chromosome segregation (GO:0045132)	3.03030635
36	protein K63-linked deubiquitination (GO:0070536)	3.02802634
37	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.01239363
38	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.97280012
39	oogenesis (GO:0048477)	2.94320228
40	regulation of histone H3-K9 methylation (GO:0051570)	2.94220200
41	protein targeting to vacuole (GO:0006623)	2.93952755
42	protein targeting to lysosome (GO:0006622)	2.93952755
43	establishment of protein localization to vacuole (GO:0072666)	2.93952755
44	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.90684337
45	kinetochore organization (GO:0051383)	2.86575576
46	regulation of DNA methylation (GO:0044030)	2.86534466
47	meiotic cell cycle process (GO:1903046)	2.80639636
48	histone H3-K4 trimethylation (GO:0080182)	2.79444175
49	peptidyl-lysine trimethylation (GO:0018023)	2.79134108
50	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.76863771
51	microtubule nucleation (GO:0007020)	2.76065301
52	acrosome assembly (GO:0001675)	2.74556449
53	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.74500435
54	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.74500435
55	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.74500435
56	female gamete generation (GO:0007292)	2.74284382
57	nuclear pore complex assembly (GO:0051292)	2.73692248
58	peptidyl-threonine dephosphorylation (GO:0035970)	2.73375335
59	wound healing, spreading of epidermal cells (GO:0035313)	2.72068877
60	interleukin-6-mediated signaling pathway (GO:0070102)	2.70461499
61	DNA synthesis involved in DNA repair (GO:0000731)	2.69102350
62	regulation of chromatin silencing (GO:0031935)	2.64045875
63	mitotic chromosome condensation (GO:0007076)	2.63164546
64	protein deubiquitination (GO:0016579)	2.63000046
65	meiosis I (GO:0007127)	2.62389762
66	CENP-A containing nucleosome assembly (GO:0034080)	2.60493754
67	regulation of protein polyubiquitination (GO:1902914)	2.60487257
68	protein K6-linked ubiquitination (GO:0085020)	2.58961960
69	protein modification by small protein removal (GO:0070646)	2.56266683
70	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.54662516
71	isotype switching (GO:0045190)	2.54662516
72	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.54662516
73	chromatin remodeling at centromere (GO:0031055)	2.53188818
74	oocyte development (GO:0048599)	2.50885019
75	snRNA transcription (GO:0009301)	2.48662054
76	histone H3-K36 demethylation (GO:0070544)	2.47949422
77	regulation of establishment of cell polarity (GO:2000114)	2.47871538
78	mitotic cell cycle arrest (GO:0071850)	2.47623545
79	gonadal mesoderm development (GO:0007506)	2.47608662
80	positive regulation of T cell cytokine production (GO:0002726)	2.47329241
81	positive regulation of developmental pigmentation (GO:0048087)	2.47244745
82	centriole assembly (GO:0098534)	2.45696443
83	reciprocal DNA recombination (GO:0035825)	2.45572515
84	reciprocal meiotic recombination (GO:0007131)	2.45572515
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.45090943
86	positive regulation of meiosis (GO:0045836)	2.43103171
87	protein K48-linked ubiquitination (GO:0070936)	2.43060014
88	vesicle transport along microtubule (GO:0047496)	2.41794643
89	establishment of chromosome localization (GO:0051303)	2.40998007
90	DNA double-strand break processing (GO:0000729)	2.40935600
91	Golgi to endosome transport (GO:0006895)	2.39098333
92	negative regulation of lipid storage (GO:0010888)	2.37563406
93	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.36867774
94	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.36279477
95	regulation of cilium movement (GO:0003352)	2.35967076
96	histone H3-K9 demethylation (GO:0033169)	2.35032614
97	regulation of mitotic spindle checkpoint (GO:1903504)	2.35021434
98	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.35021434
99	synaptonemal complex assembly (GO:0007130)	2.33406296
100	nuclear pore organization (GO:0006999)	2.32860264

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.80823582
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.38834472
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16083475
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.95000161
5	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.74179127
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.50488376
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.35423618
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28024256
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22778163
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.20126850
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.19191325
12	FUS_26573619_Chip-Seq_HEK293_Human	2.18692986
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14714307
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.03211169
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97264595
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.94771098
17	VDR_22108803_ChIP-Seq_LS180_Human	1.88778419
18	* EWS_26573619_Chip-Seq_HEK293_Human	1.85157565
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81471098
20	P300_19829295_ChIP-Seq_ESCs_Human	1.78009877
21	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.75770536
22	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.74388857
23	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.70871894
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67526042
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67064906
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66412718
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63638449
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.62955738
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.60581014
30	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.58875815
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56593866
32	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.53773577
33	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.51379583
34	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.50530452
35	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.50172704
36	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.50056080
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48403635
38	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.48261004
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48038150
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47079706
41	STAT3_23295773_ChIP-Seq_U87_Human	1.46669492
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46415362
43	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.46411572
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.42756710
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42756710
46	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.39826767
47	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.39826767
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39776503
49	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.39131284
50	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.39114736
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38817861
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.38808525
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38278797
54	TP53_16413492_ChIP-PET_HCT116_Human	1.37227591
55	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.36118240
56	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.34667437
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33309998
58	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.32186848
59	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.30925624
60	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.27961842
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27653517
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.26214158
63	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.26092974
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25542082
65	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.25386172
66	TCF4_23295773_ChIP-Seq_U87_Human	1.23630049
67	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23056716
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21487724
69	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.20561256
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19818673
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19590485
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18802269
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18683633
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18670502
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18009517
76	AR_25329375_ChIP-Seq_VCAP_Human	1.17669119
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.17371430
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15914281
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15366905
80	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.15302172
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14388677
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14036847
83	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13696036
84	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.13317490
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.12736660
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10742619
87	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.09342682
88	P300_18555785_Chip-Seq_ESCs_Mouse	1.09228701
89	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.07824235
90	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.06787422
91	E2F7_22180533_ChIP-Seq_HELA_Human	1.06630083
92	BCAT_22108803_ChIP-Seq_LS180_Human	1.05973052
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04819924
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04566215
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03834195
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02711165
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02576278
98	VDR_24787735_ChIP-Seq_THP-1_Human	1.02453352
99	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.01600842
100	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.01600842

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.33755032
2	MP0008057_abnormal_DNA_replication	4.83177347
3	MP0000569_abnormal_digit_pigmentation	3.92836456
4	MP0003724_increased_susceptibility_to	3.79229910
5	MP0003950_abnormal_plasma_membrane	2.59731212
6	MP0002102_abnormal_ear_morphology	2.58720934
7	MP0008058_abnormal_DNA_repair	2.51723491
8	MP0003656_abnormal_erythrocyte_physiolo	2.35802743
9	MP0000383_abnormal_hair_follicle	2.32154876
10	MP0006054_spinal_hemorrhage	2.30165946
11	MP0002009_preneoplasia	2.28821372
12	MP0000015_abnormal_ear_pigmentation	2.16003295
13	MP0003221_abnormal_cardiomyocyte_apopto	2.05364581
14	MP0003828_pulmonary_edema	2.03485136
15	MP0010678_abnormal_skin_adnexa	1.99606218
16	MP0003890_abnormal_embryonic-extraembry	1.81748696
17	MP0005310_abnormal_salivary_gland	1.74786491
18	MP0005248_abnormal_Harderian_gland	1.73475653
19	MP0010094_abnormal_chromosome_stability	1.71718643
20	MP0003183_abnormal_peptide_metabolism	1.62864712
21	MP0010352_gastrointestinal_tract_polyps	1.61796524
22	MP0003303_peritoneal_inflammation	1.60111166
23	MP0010307_abnormal_tumor_latency	1.57880037
24	MP0004808_abnormal_hematopoietic_stem	1.54483429
25	MP0000427_abnormal_hair_cycle	1.49526904
26	MP0001800_abnormal_humoral_immune	1.48855432
27	MP0001929_abnormal_gametogenesis	1.43859033
28	MP0005397_hematopoietic_system_phenotyp	1.42281222
29	MP0001545_abnormal_hematopoietic_system	1.42281222
30	MP0003195_calcinosis	1.41080736
31	MP0008260_abnormal_autophagy	1.40927460
32	MP0009697_abnormal_copulation	1.40578109
33	MP0003943_abnormal_hepatobiliary_system	1.35030012
34	MP0000465_gastrointestinal_hemorrhage	1.34820382
35	MP0002006_tumorigenesis	1.31593421
36	MP0010386_abnormal_urinary_bladder	1.30614461
37	MP0002095_abnormal_skin_pigmentation	1.29396470
38	MP0002210_abnormal_sex_determination	1.26551149
39	MP0002166_altered_tumor_susceptibility	1.22287695
40	MP0003077_abnormal_cell_cycle	1.21943288
41	MP0005174_abnormal_tail_pigmentation	1.21807520
42	MP0001879_abnormal_lymphatic_vessel	1.21566132
43	MP0002332_abnormal_exercise_endurance	1.18316784
44	MP0003787_abnormal_imprinting	1.18287129
45	MP0001835_abnormal_antigen_presentation	1.18253856
46	MP0005647_abnormal_sex_gland	1.16496910
47	MP0005000_abnormal_immune_tolerance	1.14755533
48	MP0000653_abnormal_sex_gland	1.11904967
49	MP0005075_abnormal_melanosome_morpholog	1.10462867
50	MP0003763_abnormal_thymus_physiology	1.09809465
51	MP0002396_abnormal_hematopoietic_system	1.09529253
52	MP0002723_abnormal_immune_serum	1.09233977
53	MP0001919_abnormal_reproductive_system	1.09148872
54	MP0003436_decreased_susceptibility_to	1.08839807
55	MP0000372_irregular_coat_pigmentation	1.08818812
56	MP0000013_abnormal_adipose_tissue	1.08018127
57	MP0002452_abnormal_antigen_presenting	1.07983507
58	MP0010368_abnormal_lymphatic_system	1.07300899
59	MP0003300_gastrointestinal_ulcer	1.05161007
60	MP0009115_abnormal_fat_cell	1.03590562
61	MP0009785_altered_susceptibility_to	1.03014656
62	MP0001119_abnormal_female_reproductive	1.02215830
63	MP0001145_abnormal_male_reproductive	0.99962256
64	MP0004484_altered_response_of	0.96838450
65	MP0005389_reproductive_system_phenotype	0.93418897
66	MP0002398_abnormal_bone_marrow	0.92871894
67	MP0001177_atelectasis	0.92686401
68	MP0002928_abnormal_bile_duct	0.92603833
69	MP0003121_genomic_imprinting	0.92056534
70	MP0000689_abnormal_spleen_morphology	0.89952563
71	MP0003111_abnormal_nucleus_morphology	0.84227600
72	MP0001851_eye_inflammation	0.83869787
73	MP0001191_abnormal_skin_condition	0.82929165
74	MP0001819_abnormal_immune_cell	0.82586927
75	MP0002420_abnormal_adaptive_immunity	0.81609328
76	MP0005671_abnormal_response_to	0.80291129
77	MP0008007_abnormal_cellular_replicative	0.79861668
78	MP0004215_abnormal_myocardial_fiber	0.79829272
79	MP0004957_abnormal_blastocyst_morpholog	0.79334663
80	MP0004197_abnormal_fetal_growth/weight/	0.79200399
81	MP0001790_abnormal_immune_system	0.78801857
82	MP0005387_immune_system_phenotype	0.78801857
83	MP0002148_abnormal_hypersensitivity_rea	0.78375528
84	MP0004043_abnormal_pH_regulation	0.76573515
85	MP0004142_abnormal_muscle_tone	0.75984098
86	MP0000716_abnormal_immune_system	0.74448017
87	MP0005253_abnormal_eye_physiology	0.74378359
88	MP0003698_abnormal_male_reproductive	0.73214905
89	MP0002722_abnormal_immune_system	0.72493571
90	MP0003880_abnormal_central_pattern	0.71074008
91	MP0002133_abnormal_respiratory_system	0.70188236
92	MP0005388_respiratory_system_phenotype	0.70188236
93	MP0001324_abnormal_eye_pigmentation	0.68916360
94	MP0003699_abnormal_female_reproductive	0.67573283
95	MP0000703_abnormal_thymus_morphology	0.67277072
96	MP0000371_diluted_coat_color	0.67075714
97	MP0009764_decreased_sensitivity_to	0.63735610
98	MP0005621_abnormal_cell_physiology	0.63719586
99	MP0002419_abnormal_innate_immunity	0.63423799
100	MP0010155_abnormal_intestine_physiology	0.63156954

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	4.70252951
2	Volvulus (HP:0002580)	4.62948035
3	Chromsome breakage (HP:0040012)	4.45553534
4	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.71911055
5	Stomach cancer (HP:0012126)	3.34611275
6	Thyroid carcinoma (HP:0002890)	3.16713973
7	Abnormality of chromosome stability (HP:0003220)	3.15530586
8	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.99476589
9	B lymphocytopenia (HP:0010976)	2.80954100
10	Thyroiditis (HP:0100646)	2.72449430
11	Short tibia (HP:0005736)	2.69074062
12	Abnormality of B cell number (HP:0010975)	2.68993183
13	Fair hair (HP:0002286)	2.64127101
14	Oligodactyly (hands) (HP:0001180)	2.63291142
15	Disinhibition (HP:0000734)	2.63076422
16	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.55829915
17	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.55829915
18	Central scotoma (HP:0000603)	2.52648337
19	T lymphocytopenia (HP:0005403)	2.51644505
20	Amyotrophic lateral sclerosis (HP:0007354)	2.50985618
21	Medulloblastoma (HP:0002885)	2.41433645
22	Medial flaring of the eyebrow (HP:0010747)	2.40342406
23	Scotoma (HP:0000575)	2.39721202
24	Horizontal nystagmus (HP:0000666)	2.37862479
25	Progressive inability to walk (HP:0002505)	2.31298748
26	Subacute progressive viral hepatitis (HP:0006572)	2.30888670
27	Abnormality of T cell number (HP:0011839)	2.29748975
28	Menstrual irregularities (HP:0000858)	2.29289132
29	Gonadotropin excess (HP:0000837)	2.28485847
30	Acute myeloid leukemia (HP:0004808)	2.26650938
31	Embryonal renal neoplasm (HP:0011794)	2.25656574
32	Neoplasm of the tracheobronchial system (HP:0100552)	2.24603697
33	Combined immunodeficiency (HP:0005387)	2.24324754
34	Congenital primary aphakia (HP:0007707)	2.22059638
35	Inappropriate behavior (HP:0000719)	2.21728075
36	Nephroblastoma (Wilms tumor) (HP:0002667)	2.19768095
37	Abnormal auditory evoked potentials (HP:0006958)	2.19074333
38	Shoulder girdle muscle weakness (HP:0003547)	2.17637970
39	Severe combined immunodeficiency (HP:0004430)	2.17173978
40	Generalized hypopigmentation of hair (HP:0011358)	2.16447512
41	Microglossia (HP:0000171)	2.16447182
42	Stomatitis (HP:0010280)	2.16420700
43	Transitional cell carcinoma of the bladder (HP:0006740)	2.14257808
44	Gait imbalance (HP:0002141)	2.12902333
45	Supernumerary spleens (HP:0009799)	2.12727879
46	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.12296232
47	Biliary tract neoplasm (HP:0100574)	2.11016392
48	Nephrogenic diabetes insipidus (HP:0009806)	2.08486998
49	Osteomalacia (HP:0002749)	2.07224350
50	Abnormal hair whorl (HP:0010721)	2.06985657
51	Anhidrosis (HP:0000970)	2.04749096
52	Median cleft lip (HP:0000161)	2.04015215
53	Bladder carcinoma (HP:0002862)	2.02110614
54	Bladder neoplasm (HP:0009725)	2.02110614
55	Absent speech (HP:0001344)	2.00293574
56	Truncal obesity (HP:0001956)	2.00025963
57	Prostate neoplasm (HP:0100787)	1.99951670
58	Oligodactyly (HP:0012165)	1.96945978
59	Albinism (HP:0001022)	1.95500556
60	Vertebral arch anomaly (HP:0008438)	1.95340167
61	Alveolar cell carcinoma (HP:0006519)	1.94937702
62	Abnormality of the corticospinal tract (HP:0002492)	1.94902655
63	Gaze-evoked nystagmus (HP:0000640)	1.94061968
64	Abnormality of the hip-girdle musculature (HP:0001445)	1.93203361
65	Abnormality of the musculature of the pelvis (HP:0001469)	1.93203361
66	Basal cell carcinoma (HP:0002671)	1.91891996
67	Chronic hepatic failure (HP:0100626)	1.90805454
68	Chronic diarrhea (HP:0002028)	1.90482431
69	Thickened calvaria (HP:0002684)	1.88725921
70	Abnormality of DNA repair (HP:0003254)	1.88541448
71	Heterotopia (HP:0002282)	1.88414904
72	Rhabdomyosarcoma (HP:0002859)	1.88159224
73	Genital tract atresia (HP:0001827)	1.86863451
74	Ectopic kidney (HP:0000086)	1.86046409
75	Clubbing of toes (HP:0100760)	1.85907434
76	Cutaneous melanoma (HP:0012056)	1.84369811
77	Panhypogammaglobulinemia (HP:0003139)	1.82568686
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81563961
79	Astigmatism (HP:0000483)	1.81299318
80	Retrobulbar optic neuritis (HP:0100654)	1.79581551
81	Optic neuritis (HP:0100653)	1.79581551
82	Renal cortical cysts (HP:0000803)	1.78973605
83	Uterine leiomyosarcoma (HP:0002891)	1.75748993
84	Leiomyosarcoma (HP:0100243)	1.75748993
85	Poor coordination (HP:0002370)	1.75454728
86	Ectropion (HP:0000656)	1.74025126
87	Small intestinal stenosis (HP:0012848)	1.73977863
88	Duodenal stenosis (HP:0100867)	1.73977863
89	Capillary hemangiomas (HP:0005306)	1.73807071
90	Abnormality of the left ventricular outflow tract (HP:0011103)	1.73504915
91	Subaortic stenosis (HP:0001682)	1.73504915
92	Dyskinesia (HP:0100660)	1.73442895
93	Dyschromatopsia (HP:0007641)	1.72958067
94	Cystic hygroma (HP:0000476)	1.72799820
95	Pelvic girdle muscle weakness (HP:0003749)	1.72271350
96	Tented upper lip vermilion (HP:0010804)	1.71842942
97	Poikiloderma (HP:0001029)	1.71303776
98	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.70028202
99	Abnormality of eosinophils (HP:0001879)	1.69347206
100	Cupped ear (HP:0000378)	1.69147705

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	3.62037227
2	PLK4	3.30895108
3	NEK1	2.78830878
4	NUAK1	2.78099261
5	BRSK2	2.73606114
6	FRK	2.69068139
7	BRD4	2.61253410
8	TRIM28	2.46505057
9	BMPR1B	2.33487303
10	LATS1	2.14246692
11	BCR	2.09831963
12	TAOK3	2.07230801
13	EIF2AK3	1.89643550
14	CDK12	1.85054416
15	MAP3K14	1.81123118
16	WEE1	1.79745745
17	MAP3K4	1.74231905
18	ERBB3	1.69982247
19	PNCK	1.66721057
20	STK3	1.59290038
21	CDK8	1.53555514
22	PLK2	1.51739107
23	STK38L	1.49538141
24	SIK3	1.45002891
25	TXK	1.42870157
26	PDK2	1.42600456
27	STK24	1.41672311
28	IKBKE	1.25985018
29	BMPR2	1.24699625
30	YES1	1.22929716
31	NEK6	1.19149152
32	NEK9	1.15895084
33	IRAK1	1.08175993
34	CAMKK2	1.07889790
35	MAP3K5	1.03426557
36	MAPK13	1.03162202
37	NEK2	1.02097585
38	KSR1	1.00788957
39	NLK	0.96004372
40	MAP3K6	0.95933296
41	CASK	0.95810978
42	RAF1	0.94942696
43	CDK9	0.93865996
44	PIK3CG	0.91613318
45	EIF2AK2	0.90903402
46	GRK7	0.90650233
47	AKT3	0.90281194
48	CDK6	0.89983292
49	MARK3	0.85852452
50	DYRK3	0.85241209
51	MST4	0.82012533
52	TNIK	0.81959528
53	PIM1	0.81013543
54	JAK1	0.76919299
55	CHUK	0.71390452
56	MATK	0.69936648
57	PINK1	0.69892231
58	MAPK7	0.69196668
59	TEC	0.68202370
60	WNK3	0.67587047
61	MKNK2	0.65937986
62	CSNK1G2	0.65618115
63	MELK	0.65595456
64	JAK3	0.63745294
65	MAP3K12	0.61951930
66	MAP3K2	0.60431225
67	CSF1R	0.59473181
68	IKBKB	0.58755851
69	SGK2	0.57054046
70	RPS6KB1	0.55748013
71	CDK3	0.55434073
72	MAP2K4	0.53488968
73	ATM	0.53324897
74	STK39	0.51277004
75	ABL1	0.51227531
76	TYK2	0.49766600
77	IRAK2	0.47578868
78	HCK	0.46560805
79	FGFR3	0.46339150
80	CDK19	0.46306511
81	EGFR	0.46286562
82	SYK	0.45905624
83	IRAK4	0.44015639
84	ERBB4	0.43877804
85	CSNK1G1	0.43821297
86	TGFBR1	0.43313349
87	PDGFRB	0.42733950
88	MAP2K7	0.41162197
89	CCNB1	0.40295792
90	CSNK1A1L	0.40105517
91	RPS6KA4	0.39366006
92	TRPM7	0.39252939
93	DYRK1A	0.39029531
94	LCK	0.38403902
95	WNK1	0.37731858
96	TIE1	0.37518663
97	PIK3CA	0.36125365
98	JAK2	0.34487255
99	MAP3K7	0.34438097
100	PLK1	0.31793540

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	2.97690641
2	Basal transcription factors_Homo sapiens_hsa03022	2.44841725
3	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.35884845
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.26924958
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.21788113
6	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	2.06365796
7	p53 signaling pathway_Homo sapiens_hsa04115	1.99301544
8	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.82462310
9	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.77727457
10	Circadian rhythm_Homo sapiens_hsa04710	1.71780307
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66145343
12	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.65813045
13	Legionellosis_Homo sapiens_hsa05134	1.64439713
14	Cell cycle_Homo sapiens_hsa04110	1.61932980
15	TNF signaling pathway_Homo sapiens_hsa04668	1.57557422
16	Measles_Homo sapiens_hsa05162	1.55026031
17	Regulation of autophagy_Homo sapiens_hsa04140	1.42918667
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.41685119
19	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.41035798
20	Osteoclast differentiation_Homo sapiens_hsa04380	1.39461606
21	Hepatitis B_Homo sapiens_hsa05161	1.37220079
22	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.35000567
23	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.34380557
24	RNA degradation_Homo sapiens_hsa03018	1.28604794
25	Leishmaniasis_Homo sapiens_hsa05140	1.26979437
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.25590687
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20750012
28	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.16120742
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.15982505
30	FoxO signaling pathway_Homo sapiens_hsa04068	1.15897851
31	Colorectal cancer_Homo sapiens_hsa05210	1.09994792
32	Toxoplasmosis_Homo sapiens_hsa05145	1.09864778
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09075534
34	Herpes simplex infection_Homo sapiens_hsa05168	1.08014949
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07619816
36	mTOR signaling pathway_Homo sapiens_hsa04150	1.07337591
37	Shigellosis_Homo sapiens_hsa05131	1.06557117
38	Influenza A_Homo sapiens_hsa05164	1.02528130
39	Prolactin signaling pathway_Homo sapiens_hsa04917	1.02319419
40	Homologous recombination_Homo sapiens_hsa03440	1.02184116
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.00045780
42	Protein export_Homo sapiens_hsa03060	0.95381670
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94090114
44	Prostate cancer_Homo sapiens_hsa05215	0.93577003
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91605816
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.91040616
47	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.89093815
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.89005991
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.88629639
50	Oocyte meiosis_Homo sapiens_hsa04114	0.88545847
51	Pancreatic cancer_Homo sapiens_hsa05212	0.88183667
52	Viral carcinogenesis_Homo sapiens_hsa05203	0.87053013
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85494285
54	Tuberculosis_Homo sapiens_hsa05152	0.84682626
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.83876581
56	Hepatitis C_Homo sapiens_hsa05160	0.83697658
57	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.83689240
58	Mismatch repair_Homo sapiens_hsa03430	0.83016595
59	ErbB signaling pathway_Homo sapiens_hsa04012	0.81946632
60	Malaria_Homo sapiens_hsa05144	0.79381276
61	Chemokine signaling pathway_Homo sapiens_hsa04062	0.79302969
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74702632
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.74138599
64	Small cell lung cancer_Homo sapiens_hsa05222	0.73023174
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.72422720
66	Acute myeloid leukemia_Homo sapiens_hsa05221	0.72266601
67	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66118999
68	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.66063622
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65632280
70	Salmonella infection_Homo sapiens_hsa05132	0.64859591
71	Renal cell carcinoma_Homo sapiens_hsa05211	0.64611014
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64186820
73	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.63903505
74	RNA transport_Homo sapiens_hsa03013	0.63850174
75	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63720560
76	Endometrial cancer_Homo sapiens_hsa05213	0.63359493
77	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.62136057
78	Thyroid cancer_Homo sapiens_hsa05216	0.59389461
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58441408
80	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.56954353
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56798768
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56460520
83	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.56032931
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.55668160
85	Pertussis_Homo sapiens_hsa05133	0.55652264
86	Melanoma_Homo sapiens_hsa05218	0.52297274
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51865725
88	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51595208
89	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.50049160
90	Apoptosis_Homo sapiens_hsa04210	0.48986879
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46821968
92	HTLV-I infection_Homo sapiens_hsa05166	0.46151075
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.45726020
94	Adherens junction_Homo sapiens_hsa04520	0.45609306
95	Allograft rejection_Homo sapiens_hsa05330	0.45141033
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45062016
97	Long-term depression_Homo sapiens_hsa04730	0.44923802
98	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.44788311
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.43900665
100	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.42834717

ZNF654

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »