ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of glycoprotein biosynthetic process (GO:0010560)	5.62244881
2	mitotic sister chromatid cohesion (GO:0007064)	5.31690488
3	interkinetic nuclear migration (GO:0022027)	5.13626196
4	regulation of protein glycosylation (GO:0060049)	5.02569596
5	regulation of Rac protein signal transduction (GO:0035020)	4.86375232
6	gonadal mesoderm development (GO:0007506)	4.58539148
7	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	4.49774438
8	limb bud formation (GO:0060174)	4.29729429
9	positive regulation of glycoprotein metabolic process (GO:1903020)	4.22011527
10	energy homeostasis (GO:0097009)	4.13626698
11	regulation of meiosis I (GO:0060631)	4.10222929
12	autophagic vacuole fusion (GO:0000046)	3.92330999
13	inner mitochondrial membrane organization (GO:0007007)	3.86687886
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.85915883
15	keratinocyte development (GO:0003334)	3.82827857
16	amino-acid betaine metabolic process (GO:0006577)	3.79456733
17	carnitine metabolic process (GO:0009437)	3.71126031
18	piRNA metabolic process (GO:0034587)	3.69347348
19	otic vesicle formation (GO:0030916)	3.68707628
20	regulation of male gonad development (GO:2000018)	3.65781264
21	positive regulation of male gonad development (GO:2000020)	3.60396466
22	limb development (GO:0060173)	3.53290998
23	appendage development (GO:0048736)	3.53290998
24	histone mRNA catabolic process (GO:0071044)	3.51174221
25	organelle membrane fusion (GO:0090174)	3.46825431
26	activation of Rac GTPase activity (GO:0032863)	3.45773567
27	Golgi to endosome transport (GO:0006895)	3.41297588
28	fucose catabolic process (GO:0019317)	3.40557813
29	L-fucose metabolic process (GO:0042354)	3.40557813
30	L-fucose catabolic process (GO:0042355)	3.40557813
31	nucleus localization (GO:0051647)	3.40529427
32	artery smooth muscle contraction (GO:0014824)	3.29777351
33	regulation of establishment of cell polarity (GO:2000114)	3.29036245
34	phasic smooth muscle contraction (GO:0014821)	3.22156472
35	retinal ganglion cell axon guidance (GO:0031290)	3.17025053
36	cerebral cortex radially oriented cell migration (GO:0021799)	3.14653347
37	ganglion development (GO:0061548)	3.14121070
38	epithelial cilium movement (GO:0003351)	3.07428400
39	innervation (GO:0060384)	3.07390003
40	intraciliary transport (GO:0042073)	3.01687465
41	protein K11-linked deubiquitination (GO:0035871)	2.97835146
42	cilium movement (GO:0003341)	2.95973171
43	microtubule nucleation (GO:0007020)	2.95850098
44	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.92638087
45	respiratory chain complex IV assembly (GO:0008535)	2.92480865
46	male meiosis I (GO:0007141)	2.90743672
47	cilium morphogenesis (GO:0060271)	2.90621398
48	lactate metabolic process (GO:0006089)	2.88453151
49	magnesium ion transport (GO:0015693)	2.88098799
50	male meiosis (GO:0007140)	2.86497972
51	neural tube formation (GO:0001841)	2.85748470
52	somite rostral/caudal axis specification (GO:0032525)	2.82898107
53	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.82758926
54	sister chromatid cohesion (GO:0007062)	2.81898736
55	positive regulation of meiosis (GO:0045836)	2.81220300
56	kidney morphogenesis (GO:0060993)	2.79259914
57	polyol catabolic process (GO:0046174)	2.77724712
58	negative regulation of JUN kinase activity (GO:0043508)	2.77278465
59	vascular smooth muscle contraction (GO:0014829)	2.76718911
60	inner ear receptor cell development (GO:0060119)	2.71839537
61	cytochrome complex assembly (GO:0017004)	2.68565480
62	cytoplasmic microtubule organization (GO:0031122)	2.68464347
63	basic amino acid transport (GO:0015802)	2.66995919
64	diterpenoid biosynthetic process (GO:0016102)	2.66527270
65	tonic smooth muscle contraction (GO:0014820)	2.66449735
66	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.65646613
67	aggressive behavior (GO:0002118)	2.65007839
68	thyroid hormone metabolic process (GO:0042403)	2.63576907
69	proline transport (GO:0015824)	2.62587126
70	inner ear receptor stereocilium organization (GO:0060122)	2.61695709
71	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.61620994
72	smoothened signaling pathway (GO:0007224)	2.60370587
73	acrosome reaction (GO:0007340)	2.60369003
74	prostate gland growth (GO:0060736)	2.59270807
75	gene silencing by RNA (GO:0031047)	2.59086106
76	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.58511795
77	positive regulation of meiotic cell cycle (GO:0051446)	2.57247954
78	regulation of timing of cell differentiation (GO:0048505)	2.56029786
79	oxidative demethylation (GO:0070989)	2.54722029
80	somite development (GO:0061053)	2.53025615
81	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.51813207
82	presynaptic membrane assembly (GO:0097105)	2.49335720
83	histone H3-K4 trimethylation (GO:0080182)	2.49195773
84	regulation of microtubule-based movement (GO:0060632)	2.48382312
85	cilium organization (GO:0044782)	2.47275461
86	neuron fate determination (GO:0048664)	2.46801166
87	terpenoid biosynthetic process (GO:0016114)	2.46012735
88	fructose metabolic process (GO:0006000)	2.45945483
89	regulation of cilium movement (GO:0003352)	2.45634786
90	DNA unwinding involved in DNA replication (GO:0006268)	2.45465363
91	centriole replication (GO:0007099)	2.45214915
92	cilium assembly (GO:0042384)	2.45051238
93	negative regulation of Ras GTPase activity (GO:0034261)	2.44989783
94	negative regulation of epidermal cell differentiation (GO:0045605)	2.38877354
95	inositol phosphate catabolic process (GO:0071545)	2.38033421
96	type B pancreatic cell proliferation (GO:0044342)	2.37805073
97	olfactory bulb development (GO:0021772)	2.36678451
98	hindbrain development (GO:0030902)	2.35119818
99	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.35084620
100	regulation of translation, ncRNA-mediated (GO:0045974)	2.35084620

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.49624988
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.87735987
3	VDR_22108803_ChIP-Seq_LS180_Human	3.65255217
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.16381837
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.11208644
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.75438607
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.73131127
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60037253
9	FUS_26573619_Chip-Seq_HEK293_Human	2.59201710
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59106177
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57311076
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33777152
13	P300_19829295_ChIP-Seq_ESCs_Human	2.28579309
14	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.20473383
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.20357666
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.19502305
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.17857863
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.13809918
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11956363
20	EWS_26573619_Chip-Seq_HEK293_Human	1.94504433
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.93878295
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.93375902
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.88844576
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.84419821
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80836070
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.79150924
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75722438
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.73013977
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72864446
30	STAT3_23295773_ChIP-Seq_U87_Human	1.70301172
31	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69099748
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68953315
33	AR_25329375_ChIP-Seq_VCAP_Human	1.67111370
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61280696
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58181146
36	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.55402963
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52772616
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.51068889
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50748365
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.50748365
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50243317
42	TCF4_23295773_ChIP-Seq_U87_Human	1.48524672
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47193850
44	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.45941342
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44843063
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44843063
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41370630
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40933677
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39013866
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38923219
51	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.38849639
52	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.38849639
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38758639
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36823489
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.35719008
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35583253
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35535100
58	E2F7_22180533_ChIP-Seq_HELA_Human	1.35486987
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34989826
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.30050558
61	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29542062
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.28754234
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28378505
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25675726
65	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.25571828
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23150359
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19723145
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18247886
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17341165
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14400904
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14270394
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14268000
73	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13416897
74	KDM2B_26808549_Chip-Seq_REH_Human	1.12261092
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.12211424
76	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.11665116
77	P300_18555785_Chip-Seq_ESCs_Mouse	1.11466938
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10101105
79	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08723511
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08247041
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07938792
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07763889
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06752095
84	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06617900
85	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06617900
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05878027
87	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05596999
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05232211
89	AHR_22903824_ChIP-Seq_MCF-7_Human	1.03044942
90	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02371981
91	TBL1_22424771_ChIP-Seq_293T_Human	1.02258933
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01442970
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00324859
94	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.00128156
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99281779
96	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99056503
97	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.98289749
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97219045
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97083875
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95564774

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.24933044
2	MP0003787_abnormal_imprinting	3.62364498
3	MP0003123_paternal_imprinting	3.45365311
4	MP0008877_abnormal_DNA_methylation	3.24073344
5	MP0002938_white_spotting	3.03658023
6	MP0003121_genomic_imprinting	2.79980667
7	MP0000647_abnormal_sebaceous_gland	2.50996956
8	MP0005379_endocrine/exocrine_gland_phen	2.31405009
9	MP0006292_abnormal_olfactory_placode	2.23195176
10	MP0005187_abnormal_penis_morphology	2.20555977
11	MP0005174_abnormal_tail_pigmentation	2.16477048
12	MP0005253_abnormal_eye_physiology	2.02270724
13	MP0004215_abnormal_myocardial_fiber	2.00364659
14	MP0008995_early_reproductive_senescence	1.94404383
15	MP0005248_abnormal_Harderian_gland	1.92248171
16	MP0002837_dystrophic_cardiac_calcinosis	1.90871546
17	MP0003122_maternal_imprinting	1.84429227
18	MP0000427_abnormal_hair_cycle	1.72760006
19	MP0002653_abnormal_ependyma_morphology	1.71148629
20	MP0006072_abnormal_retinal_apoptosis	1.67304903
21	MP0003890_abnormal_embryonic-extraembry	1.65414802
22	MP0008058_abnormal_DNA_repair	1.56875304
23	MP0001986_abnormal_taste_sensitivity	1.52602546
24	MP0002638_abnormal_pupillary_reflex	1.45731830
25	MP0005551_abnormal_eye_electrophysiolog	1.44044090
26	MP0002163_abnormal_gland_morphology	1.41138778
27	MP0003136_yellow_coat_color	1.39167096
28	MP0003786_premature_aging	1.39102328
29	MP0008789_abnormal_olfactory_epithelium	1.39063749
30	MP0002254_reproductive_system_inflammat	1.38968194
31	MP0003119_abnormal_digestive_system	1.37913392
32	MP0002557_abnormal_social/conspecific_i	1.36302958
33	MP0006054_spinal_hemorrhage	1.35689570
34	MP0002102_abnormal_ear_morphology	1.34279121
35	MP0002095_abnormal_skin_pigmentation	1.33412329
36	MP0005647_abnormal_sex_gland	1.30018369
37	MP0000383_abnormal_hair_follicle	1.25832460
38	MP0001529_abnormal_vocalization	1.25356250
39	MP0009697_abnormal_copulation	1.21698294
40	MP0002909_abnormal_adrenal_gland	1.20227049
41	MP0000778_abnormal_nervous_system	1.18046968
42	MP0004145_abnormal_muscle_electrophysio	1.17016511
43	MP0000372_irregular_coat_pigmentation	1.16545913
44	MP0000516_abnormal_urinary_system	1.16127993
45	MP0005367_renal/urinary_system_phenotyp	1.16127993
46	MP0006035_abnormal_mitochondrial_morpho	1.15405154
47	MP0001984_abnormal_olfaction	1.14044673
48	MP0004885_abnormal_endolymph	1.13230096
49	MP0003880_abnormal_central_pattern	1.08751894
50	MP0000613_abnormal_salivary_gland	1.06010847
51	MP0000631_abnormal_neuroendocrine_gland	1.04677119
52	MP0002751_abnormal_autonomic_nervous	1.02556746
53	MP0005391_vision/eye_phenotype	1.01609567
54	MP0009703_decreased_birth_body	1.01528518
55	MP0009046_muscle_twitch	0.98047019
56	MP0001929_abnormal_gametogenesis	0.95556940
57	MP0002971_abnormal_brown_adipose	0.92209574
58	MP0000566_synostosis	0.91794247
59	MP0010352_gastrointestinal_tract_polyps	0.91494441
60	MP0004084_abnormal_cardiac_muscle	0.90705907
61	MP0003698_abnormal_male_reproductive	0.90318211
62	MP0004270_analgesia	0.88800713
63	MP0010678_abnormal_skin_adnexa	0.87604621
64	MP0005646_abnormal_pituitary_gland	0.87057019
65	MP0000653_abnormal_sex_gland	0.86880411
66	MP0003755_abnormal_palate_morphology	0.84918678
67	MP0004924_abnormal_behavior	0.83848639
68	MP0005386_behavior/neurological_phenoty	0.83848639
69	MP0002127_abnormal_cardiovascular_syste	0.83198050
70	MP0002067_abnormal_sensory_capabilities	0.82332770
71	MP0002736_abnormal_nociception_after	0.82031166
72	MP0004197_abnormal_fetal_growth/weight/	0.81886541
73	MP0008057_abnormal_DNA_replication	0.81431491
74	MP0001968_abnormal_touch/_nociception	0.80191924
75	MP0002572_abnormal_emotion/affect_behav	0.79625741
76	MP0005075_abnormal_melanosome_morpholog	0.79192624
77	MP0002272_abnormal_nervous_system	0.79172885
78	MP0005394_taste/olfaction_phenotype	0.79001829
79	MP0005499_abnormal_olfactory_system	0.79001829
80	MP0002210_abnormal_sex_determination	0.78671702
81	MP0006138_congestive_heart_failure	0.78359240
82	MP0001188_hyperpigmentation	0.77468829
83	MP0001486_abnormal_startle_reflex	0.76618685
84	MP0001145_abnormal_male_reproductive	0.75571594
85	MP0003315_abnormal_perineum_morphology	0.73727389
86	MP0003937_abnormal_limbs/digits/tail_de	0.73547820
87	MP0010307_abnormal_tumor_latency	0.73518901
88	MP0004043_abnormal_pH_regulation	0.72895708
89	MP0010368_abnormal_lymphatic_system	0.72867783
90	MP0004134_abnormal_chest_morphology	0.72651764
91	MP0010094_abnormal_chromosome_stability	0.72596357
92	MP0001346_abnormal_lacrimal_gland	0.70591663
93	MP0002109_abnormal_limb_morphology	0.69982156
94	MP0005195_abnormal_posterior_eye	0.69356336
95	MP0001944_abnormal_pancreas_morphology	0.67000311
96	MP0008775_abnormal_heart_ventricle	0.66751248
97	MP0001177_atelectasis	0.65863783
98	MP0002233_abnormal_nose_morphology	0.65649060
99	MP0008875_abnormal_xenobiotic_pharmacok	0.65326838
100	MP0002277_abnormal_respiratory_mucosa	0.64087959

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.55422645
2	True hermaphroditism (HP:0010459)	3.26939294
3	Molar tooth sign on MRI (HP:0002419)	3.20780410
4	Abnormality of midbrain morphology (HP:0002418)	3.20780410
5	Congenital stationary night blindness (HP:0007642)	3.16897480
6	Intestinal atresia (HP:0011100)	3.11616772
7	Hypothermia (HP:0002045)	3.09742328
8	Pancreatic cysts (HP:0001737)	3.05053441
9	Hypoplasia of the pons (HP:0012110)	2.99123954
10	Chromsome breakage (HP:0040012)	2.96165532
11	Hepatoblastoma (HP:0002884)	2.92893021
12	Pancreatic fibrosis (HP:0100732)	2.92296004
13	Papillary thyroid carcinoma (HP:0002895)	2.88111724
14	Type II lissencephaly (HP:0007260)	2.86254132
15	Diastasis recti (HP:0001540)	2.84885801
16	Abnormality of the pons (HP:0007361)	2.76689970
17	White forelock (HP:0002211)	2.70366019
18	Cerebellar dysplasia (HP:0007033)	2.65475680
19	Medial flaring of the eyebrow (HP:0010747)	2.64855662
20	Nephronophthisis (HP:0000090)	2.64403475
21	Esophageal atresia (HP:0002032)	2.64169494
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57586039
23	Sclerocornea (HP:0000647)	2.53860566
24	Abnormality of the labia minora (HP:0012880)	2.52800659
25	Patchy hypopigmentation of hair (HP:0011365)	2.52389371
26	Gastrointestinal atresia (HP:0002589)	2.51925210
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.51867297
28	Abnormality of chromosome stability (HP:0003220)	2.49822513
29	Medulloblastoma (HP:0002885)	2.48860521
30	Volvulus (HP:0002580)	2.45333742
31	Neuroendocrine neoplasm (HP:0100634)	2.43243128
32	Absent eyebrow (HP:0002223)	2.40484780
33	Disproportionate short-trunk short stature (HP:0003521)	2.38109778
34	Drooling (HP:0002307)	2.36247032
35	Abnormality of the renal cortex (HP:0011035)	2.30702241
36	Abnormal ciliary motility (HP:0012262)	2.29739383
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28304367
38	Thyroid carcinoma (HP:0002890)	2.27322964
39	Broad-based gait (HP:0002136)	2.26355010
40	Gait imbalance (HP:0002141)	2.26320168
41	Congenital primary aphakia (HP:0007707)	2.23382619
42	Vaginal atresia (HP:0000148)	2.18926991
43	Genital tract atresia (HP:0001827)	2.18692193
44	Aqueductal stenosis (HP:0002410)	2.17047743
45	Focal motor seizures (HP:0011153)	2.16548858
46	Barrel-shaped chest (HP:0001552)	2.16512435
47	Glioma (HP:0009733)	2.16130023
48	Absent/shortened dynein arms (HP:0200106)	2.15137458
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15137458
50	Male pseudohermaphroditism (HP:0000037)	2.13812579
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.13206720
52	Excessive salivation (HP:0003781)	2.12948449
53	Abnormality of abdominal situs (HP:0011620)	2.10921914
54	Abdominal situs inversus (HP:0003363)	2.10921914
55	Dyskinesia (HP:0100660)	2.09791230
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.08275368
57	Blue irides (HP:0000635)	2.07331253
58	Neoplasm of the adrenal cortex (HP:0100641)	2.06613751
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.06569156
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06569156
61	Adrenal hypoplasia (HP:0000835)	2.06046495
62	Hyperglycinuria (HP:0003108)	2.02395677
63	Cystic liver disease (HP:0006706)	2.01842488
64	Preaxial hand polydactyly (HP:0001177)	2.01277684
65	Abnormal biliary tract morphology (HP:0012440)	2.00934757
66	Flat capital femoral epiphysis (HP:0003370)	2.00109662
67	Narrow forehead (HP:0000341)	1.99144221
68	Progressive cerebellar ataxia (HP:0002073)	1.96330299
69	Abnormality of renal excretion (HP:0011036)	1.96232848
70	Abnormality of the renal medulla (HP:0100957)	1.95269682
71	Oligodactyly (hands) (HP:0001180)	1.94110559
72	High anterior hairline (HP:0009890)	1.93281124
73	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.92701961
74	Dialeptic seizures (HP:0011146)	1.90491321
75	Tented upper lip vermilion (HP:0010804)	1.90233777
76	11 pairs of ribs (HP:0000878)	1.89936276
77	Abnormality of the antihelix (HP:0009738)	1.87425286
78	Facial shape deformation (HP:0011334)	1.86606948
79	Potter facies (HP:0002009)	1.86606948
80	Absent speech (HP:0001344)	1.86325012
81	Absence seizures (HP:0002121)	1.85678903
82	Broad nasal tip (HP:0000455)	1.85242566
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84659936
84	Nephrogenic diabetes insipidus (HP:0009806)	1.84271464
85	Astigmatism (HP:0000483)	1.82134928
86	Widely patent fontanelles and sutures (HP:0004492)	1.81494037
87	Abnormal sex determination (HP:0012244)	1.79497637
88	Sex reversal (HP:0012245)	1.79497637
89	Tubular atrophy (HP:0000092)	1.79411101
90	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79121694
91	Pheochromocytoma (HP:0002666)	1.76144601
92	Abnormality of the dental root (HP:0006486)	1.76131218
93	Taurodontia (HP:0000679)	1.76131218
94	Abnormality of permanent molar morphology (HP:0011071)	1.76131218
95	Small hand (HP:0200055)	1.73830938
96	Abnormality of the dental pulp (HP:0006479)	1.71460550
97	Postaxial hand polydactyly (HP:0001162)	1.70634307
98	Specific learning disability (HP:0001328)	1.70618724
99	Biliary tract neoplasm (HP:0100574)	1.70129142
100	Optic nerve hypoplasia (HP:0000609)	1.69654434

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	4.79955326
2	FRK	4.15841195
3	NEK9	3.75255276
4	BRSK2	2.95852770
5	PNCK	2.91709185
6	MKNK2	2.80229793
7	CDK19	2.75740958
8	MAP3K4	2.61146976
9	CASK	2.58569534
10	ACVR1B	2.42332105
11	GRK1	2.34539416
12	MAP2K7	1.82316934
13	FGFR2	1.72967144
14	WNK1	1.72854296
15	OBSCN	1.70945887
16	PTK2B	1.62539740
17	WNK4	1.47140810
18	WEE1	1.46258258
19	MKNK1	1.41966921
20	MAP3K6	1.35520945
21	CAMK1G	1.33463209
22	OXSR1	1.32826517
23	PLK2	1.32292867
24	ERBB3	1.28247408
25	PAK3	1.24772182
26	MAPK13	1.24722286
27	IRAK2	1.23738147
28	YES1	1.20225622
29	MAP2K4	1.18312013
30	MAPK15	1.17160762
31	EPHA4	1.15503320
32	IRAK1	1.15071089
33	CDC7	1.12276448
34	CAMKK2	1.10192381
35	BRSK1	1.09241911
36	PINK1	1.09005307
37	MAP4K2	1.08986499
38	BCR	1.05963885
39	ADRBK2	1.04857138
40	STK24	1.03629238
41	VRK1	1.03517676
42	CSNK1G2	1.03338358
43	WNK3	0.99629702
44	NEK1	0.96593981
45	PHKG2	0.93298137
46	PHKG1	0.93298137
47	PLK4	0.92116430
48	ROCK1	0.91072923
49	PRKCE	0.90464091
50	PLK3	0.84682203
51	NTRK2	0.82831169
52	TRIM28	0.79674797
53	FGFR3	0.78145156
54	STK38	0.77622595
55	CSNK1G1	0.77521969
56	BLK	0.77341336
57	CSNK1G3	0.74577201
58	BMPR1B	0.74277768
59	NUAK1	0.72935916
60	CAMK1D	0.72934548
61	MARK1	0.72473709
62	FER	0.67654923
63	STK39	0.67569906
64	TGFBR1	0.61706514
65	PRKAA2	0.60615135
66	SGK2	0.59071098
67	ATM	0.58606872
68	TIE1	0.58039695
69	MUSK	0.57739961
70	ERBB2	0.57633058
71	PASK	0.57112357
72	TSSK6	0.55306988
73	PRKCG	0.53783259
74	MAP3K7	0.53400882
75	AKT3	0.50817713
76	PLK1	0.50694852
77	PRKDC	0.49941828
78	FGFR1	0.48779813
79	MET	0.48755550
80	RPS6KB1	0.48504741
81	PIK3CA	0.48202426
82	STK3	0.48031839
83	NTRK3	0.47707330
84	CSNK1D	0.47102405
85	DYRK2	0.46252949
86	PRKG1	0.45538906
87	PKN1	0.41810501
88	CAMK2A	0.40587898
89	INSRR	0.39456014
90	UHMK1	0.39368752
91	DYRK1A	0.38486380
92	MAP3K2	0.38171665
93	CDK3	0.38008367
94	DAPK2	0.37644106
95	CAMK1	0.34478998
96	DMPK	0.34110652
97	CAMK4	0.33709946
98	PRKCZ	0.31367069
99	PIK3CG	0.30064904
100	EIF2AK3	0.29633015

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.75139567
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.67048841
3	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.52834359
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.33190705
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.11028171
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.92916202
7	Circadian rhythm_Homo sapiens_hsa04710	1.91777651
8	Propanoate metabolism_Homo sapiens_hsa00640	1.89975084
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89269048
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86337942
11	Phototransduction_Homo sapiens_hsa04744	1.81314353
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.79318568
13	Nicotine addiction_Homo sapiens_hsa05033	1.76175071
14	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.69486323
15	Fatty acid degradation_Homo sapiens_hsa00071	1.69340731
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64111332
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.63057307
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60805454
19	Caffeine metabolism_Homo sapiens_hsa00232	1.54497966
20	Protein export_Homo sapiens_hsa03060	1.51909502
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.51750463
22	Homologous recombination_Homo sapiens_hsa03440	1.47230485
23	Lysine degradation_Homo sapiens_hsa00310	1.44860497
24	Butanoate metabolism_Homo sapiens_hsa00650	1.44562520
25	Taste transduction_Homo sapiens_hsa04742	1.42821096
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41990443
27	Serotonergic synapse_Homo sapiens_hsa04726	1.41623332
28	Morphine addiction_Homo sapiens_hsa05032	1.39737105
29	Regulation of autophagy_Homo sapiens_hsa04140	1.39282655
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38323958
31	GABAergic synapse_Homo sapiens_hsa04727	1.37737236
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34320073
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.33991249
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.33497401
35	Histidine metabolism_Homo sapiens_hsa00340	1.33255026
36	Basal transcription factors_Homo sapiens_hsa03022	1.32441064
37	Renin-angiotensin system_Homo sapiens_hsa04614	1.25950732
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.25384133
39	Circadian entrainment_Homo sapiens_hsa04713	1.22070630
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21872251
41	Insulin secretion_Homo sapiens_hsa04911	1.20112075
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.11206177
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10095796
44	Renin secretion_Homo sapiens_hsa04924	1.07560941
45	Cocaine addiction_Homo sapiens_hsa05030	1.05690456
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05025932
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03826745
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97992586
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.97769283
50	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.97140090
51	Amphetamine addiction_Homo sapiens_hsa05031	0.95240451
52	Long-term depression_Homo sapiens_hsa04730	0.93146698
53	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.92722632
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88136398
55	Retinol metabolism_Homo sapiens_hsa00830	0.82823443
56	ABC transporters_Homo sapiens_hsa02010	0.82112973
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.80799262
58	Oocyte meiosis_Homo sapiens_hsa04114	0.80709803
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77679747
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77186586
61	RNA degradation_Homo sapiens_hsa03018	0.74822283
62	Peroxisome_Homo sapiens_hsa04146	0.70257504
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.66255293
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61093844
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.60709435
66	Salivary secretion_Homo sapiens_hsa04970	0.58917330
67	Cholinergic synapse_Homo sapiens_hsa04725	0.57376419
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57254203
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.57139272
70	DNA replication_Homo sapiens_hsa03030	0.56900097
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.56242262
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55984452
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55715085
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52881068
75	AMPK signaling pathway_Homo sapiens_hsa04152	0.51878945
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51740615
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.51478660
78	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50640432
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.50219592
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50082410
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.49829665
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49503650
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49078297
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48886813
85	RNA transport_Homo sapiens_hsa03013	0.48529982
86	Olfactory transduction_Homo sapiens_hsa04740	0.48256724
87	Tight junction_Homo sapiens_hsa04530	0.48232846
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.47956016
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47507133
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46490575
91	Axon guidance_Homo sapiens_hsa04360	0.44921562
92	Fatty acid elongation_Homo sapiens_hsa00062	0.44919162
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44875862
94	Folate biosynthesis_Homo sapiens_hsa00790	0.43155795
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.41612180
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.41563033
97	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38364912
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37617345
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37608929
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36322777

ZNF658B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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