ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.49116148
2	DNA double-strand break processing (GO:0000729)	4.44334781
3	kynurenine metabolic process (GO:0070189)	4.19695804
4	tryptophan catabolic process (GO:0006569)	4.19181230
5	indole-containing compound catabolic process (GO:0042436)	4.19181230
6	indolalkylamine catabolic process (GO:0046218)	4.19181230
7	response to pheromone (GO:0019236)	4.17111952
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.62163161
9	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.59517386
10	tryptophan metabolic process (GO:0006568)	3.58190099
11	replication fork processing (GO:0031297)	3.58075281
12	indolalkylamine metabolic process (GO:0006586)	3.48202419
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.44608101
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.44608101
15	regulation of translation, ncRNA-mediated (GO:0045974)	3.44608101
16	presynaptic membrane assembly (GO:0097105)	3.41874616
17	somite development (GO:0061053)	3.41268474
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.40271840
19	kidney morphogenesis (GO:0060993)	3.35781209
20	fucose catabolic process (GO:0019317)	3.23942570
21	L-fucose metabolic process (GO:0042354)	3.23942570
22	L-fucose catabolic process (GO:0042355)	3.23942570
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23408628
24	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.22076125
25	regulation of mitotic spindle checkpoint (GO:1903504)	3.22076125
26	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.13062512
27	neural tube formation (GO:0001841)	3.06721006
28	DNA deamination (GO:0045006)	3.03658124
29	presynaptic membrane organization (GO:0097090)	3.00315824
30	negative regulation of telomere maintenance (GO:0032205)	2.96339335
31	recombinational repair (GO:0000725)	2.94584698
32	protein polyglutamylation (GO:0018095)	2.91946125
33	gamma-aminobutyric acid transport (GO:0015812)	2.91193280
34	nucleobase catabolic process (GO:0046113)	2.90863816
35	double-strand break repair via homologous recombination (GO:0000724)	2.89995324
36	respiratory chain complex IV assembly (GO:0008535)	2.89888862
37	cytochrome complex assembly (GO:0017004)	2.89030644
38	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87972475
39	retinal cone cell development (GO:0046549)	2.83813992
40	synapsis (GO:0007129)	2.83322914
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.82315120
42	indole-containing compound metabolic process (GO:0042430)	2.80485685
43	prenylation (GO:0097354)	2.80151629
44	protein prenylation (GO:0018342)	2.80151629
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.79049372
46	epithelial cilium movement (GO:0003351)	2.79046475
47	regulation of centriole replication (GO:0046599)	2.78462772
48	cilium morphogenesis (GO:0060271)	2.78290580
49	piRNA metabolic process (GO:0034587)	2.77259874
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.77171776
51	intraciliary transport (GO:0042073)	2.76051792
52	amine catabolic process (GO:0009310)	2.75544514
53	cellular biogenic amine catabolic process (GO:0042402)	2.75544514
54	behavioral response to ethanol (GO:0048149)	2.73408362
55	limb bud formation (GO:0060174)	2.70880480
56	protein complex biogenesis (GO:0070271)	2.69898673
57	regulation of telomere maintenance (GO:0032204)	2.68098991
58	chromatin remodeling at centromere (GO:0031055)	2.67986819
59	photoreceptor cell maintenance (GO:0045494)	2.67728103
60	reciprocal DNA recombination (GO:0035825)	2.63217184
61	reciprocal meiotic recombination (GO:0007131)	2.63217184
62	detection of light stimulus involved in visual perception (GO:0050908)	2.63138486
63	detection of light stimulus involved in sensory perception (GO:0050962)	2.63138486
64	cilium organization (GO:0044782)	2.62565752
65	negative regulation of mast cell activation (GO:0033004)	2.62557442
66	nonmotile primary cilium assembly (GO:0035058)	2.60994895
67	regulation of posttranscriptional gene silencing (GO:0060147)	2.58887172
68	regulation of gene silencing by miRNA (GO:0060964)	2.58887172
69	regulation of gene silencing by RNA (GO:0060966)	2.58887172
70	histone exchange (GO:0043486)	2.58325649
71	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58174723
72	isotype switching (GO:0045190)	2.58174723
73	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58174723
74	DNA demethylation (GO:0080111)	2.56908964
75	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.56373873
76	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.56373873
77	cilium assembly (GO:0042384)	2.54715914
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.54449829
79	retinal ganglion cell axon guidance (GO:0031290)	2.53249357
80	centriole replication (GO:0007099)	2.52866708
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49961511
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.49070364
83	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.48656392
84	axoneme assembly (GO:0035082)	2.48027763
85	cell wall macromolecule catabolic process (GO:0016998)	2.47085651
86	regulation of mesoderm development (GO:2000380)	2.46271210
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45806026
88	rRNA catabolic process (GO:0016075)	2.45539160
89	double-strand break repair via nonhomologous end joining (GO:0006303)	2.43655113
90	non-recombinational repair (GO:0000726)	2.43655113
91	CENP-A containing nucleosome assembly (GO:0034080)	2.43384835
92	DNA integration (GO:0015074)	2.43139642
93	neuronal action potential (GO:0019228)	2.41798832
94	photoreceptor cell development (GO:0042461)	2.41620953
95	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.40091340
96	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.39898116
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.39898116
98	NADH dehydrogenase complex assembly (GO:0010257)	2.39898116
99	cellular ketone body metabolic process (GO:0046950)	2.38854509
100	kinetochore assembly (GO:0051382)	2.38155638

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.97361858
2	VDR_22108803_ChIP-Seq_LS180_Human	3.01839958
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.99812184
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.99367001
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70858186
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.69360021
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.63477105
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.62244117
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60414805
10	EWS_26573619_Chip-Seq_HEK293_Human	2.42567373
11	FUS_26573619_Chip-Seq_HEK293_Human	2.41837930
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.36839309
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27379133
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.25028527
15	P300_19829295_ChIP-Seq_ESCs_Human	2.22229028
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16477363
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.13367616
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09779093
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02205310
20	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01164665
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93552383
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78301402
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76278538
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72064501
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72064501
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67868295
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.65065642
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61691242
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58714271
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.58081887
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57758914
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56021778
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55522485
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55450709
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53534084
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48794519
37	STAT3_23295773_ChIP-Seq_U87_Human	1.47920584
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47782469
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47406314
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46891722
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.46514866
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46370125
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45783811
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44892121
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44546883
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42246113
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.42246113
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42065619
49	TCF4_23295773_ChIP-Seq_U87_Human	1.41916692
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41843207
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41634401
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.41153837
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38781714
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.37557921
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36358172
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36210207
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35842515
58	AR_25329375_ChIP-Seq_VCAP_Human	1.35658698
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34690705
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31740504
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31545035
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.29879265
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28423127
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27752575
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27752575
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.27277341
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27052382
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.27051551
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26475380
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26211150
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24435339
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23729532
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23422437
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21866304
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20915631
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19985016
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19706781
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15998114
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15495716
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15495716
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13154595
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12003765
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07409266
84	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06728452
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06483154
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05546562
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.03226388
88	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02202444
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01910253
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01368544
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00087893
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.99762270
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99459678
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99355282
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99025214
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98787195
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97759035
98	JUN_21703547_ChIP-Seq_K562_Human	0.96829830
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.96637639
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96276440

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.39673580
2	MP0002102_abnormal_ear_morphology	3.21917005
3	MP0003787_abnormal_imprinting	2.81355105
4	MP0003195_calcinosis	2.66542007
5	MP0006072_abnormal_retinal_apoptosis	2.60045546
6	MP0006292_abnormal_olfactory_placode	2.37560302
7	MP0008875_abnormal_xenobiotic_pharmacok	2.25085478
8	MP0002938_white_spotting	2.16564214
9	MP0005551_abnormal_eye_electrophysiolog	2.12014140
10	MP0003880_abnormal_central_pattern	2.11159245
11	MP0001968_abnormal_touch/_nociception	2.08506701
12	MP0000569_abnormal_digit_pigmentation	2.03475087
13	MP0005253_abnormal_eye_physiology	1.97221454
14	MP0001529_abnormal_vocalization	1.92899715
15	MP0002736_abnormal_nociception_after	1.88234123
16	MP0003136_yellow_coat_color	1.80024710
17	MP0008058_abnormal_DNA_repair	1.79255783
18	MP0004133_heterotaxia	1.77089030
19	MP0003121_genomic_imprinting	1.76451064
20	MP0002638_abnormal_pupillary_reflex	1.73784570
21	MP0000427_abnormal_hair_cycle	1.65334156
22	MP0001984_abnormal_olfaction	1.65061567
23	MP0004142_abnormal_muscle_tone	1.63403215
24	MP0006276_abnormal_autonomic_nervous	1.60607466
25	MP0004885_abnormal_endolymph	1.58400579
26	MP0009745_abnormal_behavioral_response	1.54355720
27	MP0001485_abnormal_pinna_reflex	1.53731583
28	MP0000631_abnormal_neuroendocrine_gland	1.52508783
29	MP0000778_abnormal_nervous_system	1.51105293
30	MP0001986_abnormal_taste_sensitivity	1.50615266
31	MP0001293_anophthalmia	1.50580046
32	MP0003890_abnormal_embryonic-extraembry	1.49949295
33	MP0002751_abnormal_autonomic_nervous	1.49811788
34	MP0008789_abnormal_olfactory_epithelium	1.48683016
35	MP0009046_muscle_twitch	1.48194077
36	MP0003937_abnormal_limbs/digits/tail_de	1.46635425
37	MP0002735_abnormal_chemical_nociception	1.46540879
38	MP0003718_maternal_effect	1.45031109
39	MP0002272_abnormal_nervous_system	1.42879927
40	MP0010094_abnormal_chromosome_stability	1.39620850
41	MP0003122_maternal_imprinting	1.38393369
42	MP0002653_abnormal_ependyma_morphology	1.37526316
43	MP0005646_abnormal_pituitary_gland	1.37060916
44	MP0001486_abnormal_startle_reflex	1.35681346
45	MP0005645_abnormal_hypothalamus_physiol	1.34995703
46	MP0002234_abnormal_pharynx_morphology	1.32358268
47	MP0000372_irregular_coat_pigmentation	1.31953605
48	MP0003646_muscle_fatigue	1.31255359
49	MP0008872_abnormal_physiological_respon	1.30783873
50	MP0003283_abnormal_digestive_organ	1.30099734
51	MP0002837_dystrophic_cardiac_calcinosis	1.25689055
52	MP0003567_abnormal_fetal_cardiomyocyte	1.24579909
53	MP0005394_taste/olfaction_phenotype	1.18196040
54	MP0005499_abnormal_olfactory_system	1.18196040
55	MP0003119_abnormal_digestive_system	1.17575479
56	MP0008995_early_reproductive_senescence	1.16829127
57	MP0004147_increased_porphyrin_level	1.16715923
58	MP0002876_abnormal_thyroid_physiology	1.15473972
59	MP0004924_abnormal_behavior	1.15420096
60	MP0005386_behavior/neurological_phenoty	1.15420096
61	MP0002557_abnormal_social/conspecific_i	1.15016332
62	MP0002572_abnormal_emotion/affect_behav	1.12172361
63	MP0008057_abnormal_DNA_replication	1.08693671
64	MP0002734_abnormal_mechanical_nocicepti	1.07583856
65	MP0002733_abnormal_thermal_nociception	1.07334411
66	MP0000516_abnormal_urinary_system	1.07201972
67	MP0005367_renal/urinary_system_phenotyp	1.07201972
68	MP0005195_abnormal_posterior_eye	1.06915459
69	MP0002160_abnormal_reproductive_system	1.06195778
70	MP0005187_abnormal_penis_morphology	1.05335363
71	MP0003011_delayed_dark_adaptation	1.05326675
72	MP0000383_abnormal_hair_follicle	1.04585907
73	MP0002184_abnormal_innervation	1.04136439
74	MP0005389_reproductive_system_phenotype	1.04037971
75	MP0005084_abnormal_gallbladder_morpholo	1.03554006
76	MP0004145_abnormal_muscle_electrophysio	1.02656510
77	MP0001970_abnormal_pain_threshold	0.99437086
78	MP0004215_abnormal_myocardial_fiber	0.99305535
79	MP0005391_vision/eye_phenotype	0.98490428
80	MP0002928_abnormal_bile_duct	0.97368334
81	MP0002752_abnormal_somatic_nervous	0.96804357
82	MP0003635_abnormal_synaptic_transmissio	0.96599617
83	MP0002067_abnormal_sensory_capabilities	0.95851748
84	MP0002064_seizures	0.95812121
85	MP0001501_abnormal_sleep_pattern	0.94750852
86	MP0004742_abnormal_vestibular_system	0.93089562
87	MP0000049_abnormal_middle_ear	0.92493647
88	MP0002063_abnormal_learning/memory/cond	0.92404914
89	MP0001286_abnormal_eye_development	0.89572935
90	MP0003878_abnormal_ear_physiology	0.88571312
91	MP0005377_hearing/vestibular/ear_phenot	0.88571312
92	MP0002233_abnormal_nose_morphology	0.88179749
93	MP0003698_abnormal_male_reproductive	0.87369736
94	MP0000647_abnormal_sebaceous_gland	0.86743590
95	MP0001929_abnormal_gametogenesis	0.85386917
96	MP0003137_abnormal_impulse_conducting	0.84388681
97	MP0010386_abnormal_urinary_bladder	0.83526418
98	MP0005423_abnormal_somatic_nervous	0.81885200
99	MP0005174_abnormal_tail_pigmentation	0.81575375
100	MP0002210_abnormal_sex_determination	0.79435006

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32395291
2	Pancreatic fibrosis (HP:0100732)	4.03565432
3	True hermaphroditism (HP:0010459)	3.97186830
4	Molar tooth sign on MRI (HP:0002419)	3.58302188
5	Abnormality of midbrain morphology (HP:0002418)	3.58302188
6	Nephronophthisis (HP:0000090)	3.34142572
7	Chronic hepatic failure (HP:0100626)	2.97046607
8	Abnormality of the labia minora (HP:0012880)	2.91527466
9	Abnormality of the renal medulla (HP:0100957)	2.89327279
10	Colon cancer (HP:0003003)	2.78459774
11	Congenital stationary night blindness (HP:0007642)	2.78046096
12	Medial flaring of the eyebrow (HP:0010747)	2.74332753
13	Cystic liver disease (HP:0006706)	2.71286627
14	Abolished electroretinogram (ERG) (HP:0000550)	2.64951828
15	Abnormality of the renal cortex (HP:0011035)	2.63522140
16	Hyperventilation (HP:0002883)	2.55220163
17	Sclerocornea (HP:0000647)	2.43686522
18	Attenuation of retinal blood vessels (HP:0007843)	2.43659199
19	Tubular atrophy (HP:0000092)	2.42832717
20	Intestinal atresia (HP:0011100)	2.39807093
21	Gaze-evoked nystagmus (HP:0000640)	2.34376652
22	Gait imbalance (HP:0002141)	2.29668956
23	Type II lissencephaly (HP:0007260)	2.27903226
24	Increased corneal curvature (HP:0100692)	2.25628766
25	Keratoconus (HP:0000563)	2.25628766
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24253649
27	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.23465020
28	Pendular nystagmus (HP:0012043)	2.22982025
29	Inability to walk (HP:0002540)	2.22655159
30	Supernumerary spleens (HP:0009799)	2.22163471
31	Congenital primary aphakia (HP:0007707)	2.20706421
32	Oligodactyly (hands) (HP:0001180)	2.18229167
33	Postaxial foot polydactyly (HP:0001830)	2.17491536
34	Lissencephaly (HP:0001339)	2.15917737
35	Stomach cancer (HP:0012126)	2.13175343
36	Congenital hepatic fibrosis (HP:0002612)	2.11836689
37	Methylmalonic acidemia (HP:0002912)	2.10869391
38	Genital tract atresia (HP:0001827)	2.10553028
39	Patellar aplasia (HP:0006443)	2.09355688
40	Neoplasm of the adrenal cortex (HP:0100641)	2.07963164
41	Anencephaly (HP:0002323)	2.07234815
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.06845270
43	Abnormality of the ileum (HP:0001549)	2.06566407
44	Meckel diverticulum (HP:0002245)	2.05908549
45	Thyroiditis (HP:0100646)	2.05852458
46	Vaginal atresia (HP:0000148)	2.05678980
47	Preaxial hand polydactyly (HP:0001177)	2.05386324
48	Small hand (HP:0200055)	2.05258374
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04840040
50	Abnormality of alanine metabolism (HP:0010916)	2.04840040
51	Hyperalaninemia (HP:0003348)	2.04840040
52	Progressive inability to walk (HP:0002505)	2.04745561
53	Nephrogenic diabetes insipidus (HP:0009806)	2.03947280
54	Abnormal biliary tract physiology (HP:0012439)	2.03883954
55	Bile duct proliferation (HP:0001408)	2.03883954
56	Furrowed tongue (HP:0000221)	2.02035545
57	Anophthalmia (HP:0000528)	1.99091321
58	Abnormal drinking behavior (HP:0030082)	1.98821002
59	Polydipsia (HP:0001959)	1.98821002
60	Hyperglycinemia (HP:0002154)	1.98671212
61	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98510754
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97963025
63	Renal cortical cysts (HP:0000803)	1.97875118
64	Optic nerve hypoplasia (HP:0000609)	1.97785713
65	Hyperglycinuria (HP:0003108)	1.97007373
66	Postaxial hand polydactyly (HP:0001162)	1.96231259
67	Broad-based gait (HP:0002136)	1.93826242
68	Male pseudohermaphroditism (HP:0000037)	1.91713446
69	Aplasia/Hypoplasia of the patella (HP:0006498)	1.91304591
70	Bilateral microphthalmos (HP:0007633)	1.90581675
71	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.90535326
72	Dandy-Walker malformation (HP:0001305)	1.87690081
73	Tubulointerstitial abnormality (HP:0001969)	1.87646444
74	Decreased central vision (HP:0007663)	1.86091016
75	Septo-optic dysplasia (HP:0100842)	1.85899781
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82036944
77	Absent/shortened dynein arms (HP:0200106)	1.82036944
78	Drooling (HP:0002307)	1.79244456
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78799716
80	Abnormality of glycine metabolism (HP:0010895)	1.78799716
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77608141
82	Focal motor seizures (HP:0011153)	1.76043553
83	Hypothermia (HP:0002045)	1.75756558
84	Thyroid-stimulating hormone excess (HP:0002925)	1.74089551
85	Tubulointerstitial fibrosis (HP:0005576)	1.74015251
86	Birth length less than 3rd percentile (HP:0003561)	1.73059879
87	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.72929585
88	Pachygyria (HP:0001302)	1.69821895
89	Cupped ear (HP:0000378)	1.68124835
90	Oculomotor apraxia (HP:0000657)	1.68004947
91	Occipital encephalocele (HP:0002085)	1.67821081
92	Sloping forehead (HP:0000340)	1.67598500
93	Hypoplasia of the uterus (HP:0000013)	1.67114886
94	Astigmatism (HP:0000483)	1.66986182
95	Congenital, generalized hypertrichosis (HP:0004540)	1.66593345
96	Genetic anticipation (HP:0003743)	1.66578446
97	Hemiparesis (HP:0001269)	1.66556778
98	Febrile seizures (HP:0002373)	1.66544945
99	Narrow forehead (HP:0000341)	1.66322533
100	Abnormality of chromosome stability (HP:0003220)	1.66214525

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.94715801
2	WNK3	2.98091051
3	NUAK1	2.78701942
4	BMPR1B	2.61347908
5	ZAK	2.56316796
6	MKNK2	2.46479054
7	MAP4K2	2.41840942
8	TNIK	2.38489296
9	CASK	2.37622123
10	INSRR	2.17613610
11	ADRBK2	2.12287174
12	EIF2AK3	2.05191307
13	MAP3K4	1.88482038
14	ACVR1B	1.83480773
15	MAPK13	1.80599866
16	MKNK1	1.73872236
17	PINK1	1.67103707
18	GRK1	1.63534615
19	BRSK2	1.62098856
20	PLK3	1.43788718
21	MARK1	1.39666995
22	WEE1	1.35570111
23	FGFR2	1.33212897
24	PLK4	1.31088070
25	DYRK2	1.29418634
26	TAF1	1.27285133
27	PNCK	1.23310268
28	TRIM28	1.22443716
29	PLK2	1.18976565
30	OXSR1	1.15138659
31	VRK1	1.11079855
32	WNK4	1.07895440
33	BCR	1.04982331
34	MAP2K7	1.03626300
35	TGFBR1	1.01956208
36	CSNK1G1	1.01150665
37	TIE1	1.00711957
38	STK39	0.99950653
39	SRPK1	0.97305498
40	CSNK1G2	0.96522922
41	TAOK3	0.95260351
42	ERBB3	0.94408265
43	STK38L	0.91470868
44	NLK	0.88250369
45	VRK2	0.87186617
46	TSSK6	0.86830114
47	NTRK3	0.84851718
48	PAK3	0.84681463
49	CDC7	0.84153442
50	CSNK1G3	0.81302095
51	PRKCG	0.81281778
52	PRKCE	0.81163021
53	MST4	0.78565458
54	TLK1	0.78031095
55	BCKDK	0.77169950
56	TXK	0.75710333
57	DAPK2	0.75503866
58	PLK1	0.74904318
59	CSNK1A1L	0.73795299
60	NTRK2	0.71441399
61	ADRBK1	0.69276214
62	EIF2AK2	0.68149260
63	PIK3CA	0.67696427
64	ATR	0.65715817
65	EPHA4	0.63583093
66	PHKG2	0.60116477
67	PHKG1	0.60116477
68	FLT3	0.58186906
69	RPS6KA4	0.56245332
70	STK11	0.56147217
71	PKN1	0.55042559
72	IRAK1	0.55033319
73	STK3	0.54828562
74	CHEK2	0.54153986
75	TTK	0.52558374
76	CDK3	0.52116961
77	ATM	0.49184872
78	EIF2AK1	0.48549254
79	BUB1	0.45666525
80	CAMK2A	0.41376992
81	KIT	0.38339620
82	PASK	0.37804247
83	ERBB2	0.36747318
84	BRD4	0.35800611
85	DYRK3	0.34112192
86	OBSCN	0.33992716
87	DYRK1A	0.33965735
88	CSNK1A1	0.33722865
89	RPS6KA5	0.33622278
90	CCNB1	0.33533319
91	CSNK1D	0.33314984
92	PRKACA	0.32412346
93	NEK2	0.31802317
94	PRKG1	0.31652321
95	TEC	0.29375300
96	EPHA3	0.28039689
97	SGK2	0.26536394
98	IGF1R	0.26289455
99	PRKCQ	0.26019766
100	PRKDC	0.25070196

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.81670231
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63671369
3	Phototransduction_Homo sapiens_hsa04744	2.62885326
4	Protein export_Homo sapiens_hsa03060	2.41672295
5	Butanoate metabolism_Homo sapiens_hsa00650	2.24988799
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17981401
7	Homologous recombination_Homo sapiens_hsa03440	2.15986267
8	Nicotine addiction_Homo sapiens_hsa05033	2.09190553
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.09015057
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.02943714
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.02934870
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99138867
13	Basal transcription factors_Homo sapiens_hsa03022	1.98048699
14	Propanoate metabolism_Homo sapiens_hsa00640	1.88754065
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.88111179
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.86464843
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82645517
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.82349517
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.80523018
20	RNA polymerase_Homo sapiens_hsa03020	1.79802901
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.79652090
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73470044
23	RNA degradation_Homo sapiens_hsa03018	1.60607362
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.59918825
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53600988
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49308935
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.41421569
28	Taste transduction_Homo sapiens_hsa04742	1.40165267
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36174748
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34526631
31	Olfactory transduction_Homo sapiens_hsa04740	1.29664670
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26855691
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24883894
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17917439
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16006805
36	One carbon pool by folate_Homo sapiens_hsa00670	1.12914460
37	Parkinsons disease_Homo sapiens_hsa05012	1.10635450
38	Proteasome_Homo sapiens_hsa03050	1.10244679
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09331222
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04782166
41	Peroxisome_Homo sapiens_hsa04146	1.03086321
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00441734
43	Morphine addiction_Homo sapiens_hsa05032	0.98656888
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95299942
45	Retinol metabolism_Homo sapiens_hsa00830	0.92598687
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91409728
47	Circadian entrainment_Homo sapiens_hsa04713	0.90037585
48	GABAergic synapse_Homo sapiens_hsa04727	0.89988916
49	Serotonergic synapse_Homo sapiens_hsa04726	0.89029192
50	Mismatch repair_Homo sapiens_hsa03430	0.87356511
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86658211
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.86010183
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85773801
54	RNA transport_Homo sapiens_hsa03013	0.84404763
55	Purine metabolism_Homo sapiens_hsa00230	0.81789059
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80928042
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79769104
58	Huntingtons disease_Homo sapiens_hsa05016	0.78753536
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75698284
60	Insulin secretion_Homo sapiens_hsa04911	0.75595742
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74824423
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73632613
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72147564
64	Regulation of autophagy_Homo sapiens_hsa04140	0.65207910
65	ABC transporters_Homo sapiens_hsa02010	0.64330602
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63973453
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62423315
68	Basal cell carcinoma_Homo sapiens_hsa05217	0.62017759
69	Alzheimers disease_Homo sapiens_hsa05010	0.61072715
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.59259347
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59041151
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.58673623
73	Salivary secretion_Homo sapiens_hsa04970	0.57111889
74	Base excision repair_Homo sapiens_hsa03410	0.56635061
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.54379055
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.54325870
77	Metabolic pathways_Homo sapiens_hsa01100	0.52792592
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52017380
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51672932
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51288693
81	Oocyte meiosis_Homo sapiens_hsa04114	0.49423838
82	Lysine degradation_Homo sapiens_hsa00310	0.47834978
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46845073
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46699471
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45803136
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44779060
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.44644624
88	Fatty acid degradation_Homo sapiens_hsa00071	0.44175935
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43982850
90	Long-term depression_Homo sapiens_hsa04730	0.42606280
91	Spliceosome_Homo sapiens_hsa03040	0.41312676
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40945631
93	p53 signaling pathway_Homo sapiens_hsa04115	0.40490169
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.37549352
95	Cell cycle_Homo sapiens_hsa04110	0.36878930
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36833182
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.34093175
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.32730717
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32549748
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.31776650

ZNF660

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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