ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular ketone body metabolic process (GO:0046950)	3.97656656
2	inositol phosphate catabolic process (GO:0071545)	3.92410516
3	DNA deamination (GO:0045006)	3.81400719
4	fucose catabolic process (GO:0019317)	3.66958068
5	L-fucose metabolic process (GO:0042354)	3.66958068
6	L-fucose catabolic process (GO:0042355)	3.66958068
7	ketone body metabolic process (GO:1902224)	3.56782703
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.47815876
9	aggressive behavior (GO:0002118)	3.44395550
10	indole-containing compound catabolic process (GO:0042436)	3.39347884
11	indolalkylamine catabolic process (GO:0046218)	3.39347884
12	tryptophan catabolic process (GO:0006569)	3.39347884
13	maturation of 5.8S rRNA (GO:0000460)	3.38859081
14	axoneme assembly (GO:0035082)	3.38577277
15	behavioral response to nicotine (GO:0035095)	3.36124115
16	synapsis (GO:0007129)	3.31195710
17	platelet dense granule organization (GO:0060155)	3.23997750
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23106112
19	polyol catabolic process (GO:0046174)	3.22783066
20	indolalkylamine metabolic process (GO:0006586)	3.20955453
21	tryptophan metabolic process (GO:0006568)	3.17371151
22	protein complex biogenesis (GO:0070271)	3.14915523
23	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.12507126
24	inositol phosphate dephosphorylation (GO:0046855)	3.12507126
25	piRNA metabolic process (GO:0034587)	3.12101868
26	respiratory chain complex IV assembly (GO:0008535)	3.08890728
27	negative regulation of protein oligomerization (GO:0032460)	3.07246448
28	kidney morphogenesis (GO:0060993)	3.04757862
29	regulation of glucokinase activity (GO:0033131)	3.04110674
30	regulation of hexokinase activity (GO:1903299)	3.04110674
31	detection of light stimulus involved in visual perception (GO:0050908)	3.00844281
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.00844281
33	protein prenylation (GO:0018342)	3.00152279
34	prenylation (GO:0097354)	3.00152279
35	cytochrome complex assembly (GO:0017004)	2.99660230
36	replication fork processing (GO:0031297)	2.98857017
37	retinal cone cell development (GO:0046549)	2.98202336
38	regulation of meiosis I (GO:0060631)	2.97475913
39	protein polyglutamylation (GO:0018095)	2.96549350
40	kynurenine metabolic process (GO:0070189)	2.96387436
41	glycerophospholipid catabolic process (GO:0046475)	2.95749914
42	protein-cofactor linkage (GO:0018065)	2.95438557
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91592697
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91592697
45	NADH dehydrogenase complex assembly (GO:0010257)	2.91592697
46	presynaptic membrane assembly (GO:0097105)	2.88200466
47	dentate gyrus development (GO:0021542)	2.85680844
48	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.84754983
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83240247
50	adaptation of signaling pathway (GO:0023058)	2.82533714
51	auditory receptor cell stereocilium organization (GO:0060088)	2.82488897
52	nephron epithelium morphogenesis (GO:0072088)	2.82192373
53	nephron tubule morphogenesis (GO:0072078)	2.82192373
54	neuronal action potential (GO:0019228)	2.80031426
55	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.78660408
56	renal tubule morphogenesis (GO:0061333)	2.78417527
57	response to pheromone (GO:0019236)	2.74399028
58	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.73384060
59	regulation of neurotransmitter uptake (GO:0051580)	2.72465704
60	parental behavior (GO:0060746)	2.70779875
61	regulation of cilium movement (GO:0003352)	2.70752301
62	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.69563788
63	heparin biosynthetic process (GO:0030210)	2.69108191
64	heparin metabolic process (GO:0030202)	2.69108191
65	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.68645499
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.66880719
67	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.65706247
68	regulation of action potential (GO:0098900)	2.63570851
69	nitric oxide mediated signal transduction (GO:0007263)	2.63482643
70	behavioral response to ethanol (GO:0048149)	2.62971730
71	rhodopsin mediated signaling pathway (GO:0016056)	2.62335719
72	photoreceptor cell maintenance (GO:0045494)	2.61430848
73	negative regulation of mast cell activation (GO:0033004)	2.60644936
74	inner ear receptor stereocilium organization (GO:0060122)	2.60413825
75	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.58550383
76	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58277137
77	reflex (GO:0060004)	2.57920264
78	GPI anchor metabolic process (GO:0006505)	2.56004958
79	positive regulation of meiosis (GO:0045836)	2.55992932
80	protein K11-linked deubiquitination (GO:0035871)	2.55760674
81	positive regulation of fatty acid transport (GO:2000193)	2.55643102
82	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.52803364
83	magnesium ion transport (GO:0015693)	2.52552542
84	neural tube formation (GO:0001841)	2.52284273
85	mitotic cell cycle arrest (GO:0071850)	2.52257049
86	regulation of female receptivity (GO:0045924)	2.52182822
87	indole-containing compound metabolic process (GO:0042430)	2.52130048
88	presynaptic membrane organization (GO:0097090)	2.50725156
89	nucleotide transmembrane transport (GO:1901679)	2.50555038
90	DNA methylation involved in gamete generation (GO:0043046)	2.50348055
91	mannosylation (GO:0097502)	2.49416898
92	positive regulation of glycolytic process (GO:0045821)	2.47433180
93	aromatic amino acid family catabolic process (GO:0009074)	2.46625427
94	male meiosis (GO:0007140)	2.46345907
95	cAMP catabolic process (GO:0006198)	2.46154130
96	epithelial cilium movement (GO:0003351)	2.46036480
97	cyclic nucleotide catabolic process (GO:0009214)	2.45270006
98	positive regulation of meiotic cell cycle (GO:0051446)	2.43190180
99	maternal behavior (GO:0042711)	2.42117051
100	positive regulation of prostaglandin secretion (GO:0032308)	2.41939395

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.75177803
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.61036097
3	VDR_22108803_ChIP-Seq_LS180_Human	3.26751589
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.15748169
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80989996
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79753719
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56714080
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.33235819
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.23608397
10	FUS_26573619_Chip-Seq_HEK293_Human	2.20091621
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10077218
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09278032
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07769471
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02751533
15	P300_19829295_ChIP-Seq_ESCs_Human	2.01721389
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.98298655
17	EWS_26573619_Chip-Seq_HEK293_Human	1.91881120
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90131426
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89982712
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.83565796
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.78007474
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74909822
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74434020
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.71125253
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70722549
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70667633
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67820439
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61312124
29	AR_25329375_ChIP-Seq_VCAP_Human	1.60677797
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.59201428
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56378390
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54752399
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54721244
34	TCF4_23295773_ChIP-Seq_U87_Human	1.54697863
35	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.52344393
36	STAT3_23295773_ChIP-Seq_U87_Human	1.52234944
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51332958
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50051262
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45865512
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42674330
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42236146
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40909939
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.40622541
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40622541
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39185901
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37509311
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37332383
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35933216
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34370787
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34330815
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32479348
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31620285
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30955092
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29652225
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.27940160
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.27716381
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26957520
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26957520
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.26766496
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26340401
61	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.23621302
62	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23381077
63	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23381077
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23059319
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22066028
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20579081
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20172813
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19937087
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19451326
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18325863
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17974116
72	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16306256
73	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16264208
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15200853
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15200853
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14890736
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12349609
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12041736
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.11925884
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11139613
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09847192
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09334057
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09093947
84	AR_20517297_ChIP-Seq_VCAP_Human	1.08890117
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08237207
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06865283
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05552695
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04305421
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04246962
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03594576
91	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03001322
92	MYC_18940864_ChIP-ChIP_HL60_Human	1.01996996
93	NCOR_22424771_ChIP-Seq_293T_Human	1.01958023
94	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01830022
95	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99891985
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99256534
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98724604
98	* SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98586719
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97855912
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.96969066

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.25023708
2	MP0002876_abnormal_thyroid_physiology	2.91693141
3	MP0003195_calcinosis	2.66932512
4	MP0000569_abnormal_digit_pigmentation	2.59963475
5	MP0005646_abnormal_pituitary_gland	2.51529817
6	MP0006072_abnormal_retinal_apoptosis	2.50492049
7	MP0008877_abnormal_DNA_methylation	2.43781715
8	MP0005551_abnormal_eye_electrophysiolog	2.39990290
9	MP0004885_abnormal_endolymph	2.28762901
10	MP0002102_abnormal_ear_morphology	2.20681393
11	MP0009046_muscle_twitch	2.13955045
12	MP0006292_abnormal_olfactory_placode	2.12017324
13	MP0001968_abnormal_touch/_nociception	2.11336383
14	MP0003787_abnormal_imprinting	2.08328409
15	MP0004043_abnormal_pH_regulation	2.04282092
16	MP0005645_abnormal_hypothalamus_physiol	1.91438077
17	MP0002638_abnormal_pupillary_reflex	1.86344229
18	MP0009745_abnormal_behavioral_response	1.85921421
19	MP0000427_abnormal_hair_cycle	1.84379078
20	MP0003718_maternal_effect	1.81078762
21	MP0005253_abnormal_eye_physiology	1.80164605
22	MP0009780_abnormal_chondrocyte_physiolo	1.78540292
23	MP0001986_abnormal_taste_sensitivity	1.75571035
24	MP0008872_abnormal_physiological_respon	1.74459853
25	MP0005367_renal/urinary_system_phenotyp	1.72912890
26	MP0000516_abnormal_urinary_system	1.72912890
27	MP0000631_abnormal_neuroendocrine_gland	1.71892824
28	MP0001984_abnormal_olfaction	1.70991419
29	MP0002234_abnormal_pharynx_morphology	1.69546948
30	MP0003646_muscle_fatigue	1.66582449
31	MP0002736_abnormal_nociception_after	1.63788492
32	MP0001501_abnormal_sleep_pattern	1.63470528
33	MP0003880_abnormal_central_pattern	1.62114714
34	MP0002272_abnormal_nervous_system	1.60021804
35	MP0010386_abnormal_urinary_bladder	1.55487775
36	MP0008875_abnormal_xenobiotic_pharmacok	1.53232903
37	MP0003011_delayed_dark_adaptation	1.52749844
38	MP0005379_endocrine/exocrine_gland_phen	1.50966112
39	MP0005174_abnormal_tail_pigmentation	1.48728547
40	MP0002735_abnormal_chemical_nociception	1.46693615
41	MP0000383_abnormal_hair_follicle	1.44886103
42	MP0005075_abnormal_melanosome_morpholog	1.38333829
43	MP0002254_reproductive_system_inflammat	1.36797698
44	MP0002572_abnormal_emotion/affect_behav	1.31691545
45	MP0001944_abnormal_pancreas_morphology	1.31255270
46	MP0004142_abnormal_muscle_tone	1.30016317
47	MP0006276_abnormal_autonomic_nervous	1.29099904
48	MP0002163_abnormal_gland_morphology	1.27957912
49	MP0005386_behavior/neurological_phenoty	1.26483438
50	MP0004924_abnormal_behavior	1.26483438
51	MP0005389_reproductive_system_phenotype	1.20187891
52	MP0002557_abnormal_social/conspecific_i	1.18864413
53	MP0002064_seizures	1.18659091
54	MP0002693_abnormal_pancreas_physiology	1.18329886
55	MP0000230_abnormal_systemic_arterial	1.17177403
56	MP0001970_abnormal_pain_threshold	1.16039231
57	MP0001486_abnormal_startle_reflex	1.15776852
58	MP0005220_abnormal_exocrine_pancreas	1.15308212
59	MP0003283_abnormal_digestive_organ	1.15018940
60	MP0000566_synostosis	1.14670543
61	MP0002733_abnormal_thermal_nociception	1.13094650
62	MP0004215_abnormal_myocardial_fiber	1.12670126
63	MP0001905_abnormal_dopamine_level	1.11217540
64	MP0004133_heterotaxia	1.10767162
65	MP0005084_abnormal_gallbladder_morpholo	1.10030783
66	MP0001485_abnormal_pinna_reflex	1.07204679
67	MP0000013_abnormal_adipose_tissue	1.06333987
68	MP0010678_abnormal_skin_adnexa	1.04908269
69	MP0008775_abnormal_heart_ventricle	1.04800878
70	MP0005332_abnormal_amino_acid	1.02915810
71	MP0002909_abnormal_adrenal_gland	1.01548350
72	MP0002928_abnormal_bile_duct	1.01306015
73	MP0005167_abnormal_blood-brain_barrier	1.00488600
74	MP0002160_abnormal_reproductive_system	0.98918573
75	MP0002938_white_spotting	0.96571083
76	MP0000372_irregular_coat_pigmentation	0.96089658
77	MP0010329_abnormal_lipoprotein_level	0.95349161
78	MP0002063_abnormal_learning/memory/cond	0.95088531
79	MP0001756_abnormal_urination	0.92094206
80	MP0005395_other_phenotype	0.89874782
81	MP0003633_abnormal_nervous_system	0.87055313
82	MP0003252_abnormal_bile_duct	0.86412477
83	MP0002138_abnormal_hepatobiliary_system	0.86310778
84	MP0001919_abnormal_reproductive_system	0.86212311
85	MP0005195_abnormal_posterior_eye	0.85858637
86	MP0003121_genomic_imprinting	0.85329324
87	MP0005410_abnormal_fertilization	0.84859443
88	MP0004145_abnormal_muscle_electrophysio	0.84374043
89	MP0000015_abnormal_ear_pigmentation	0.83683496
90	MP0003635_abnormal_synaptic_transmissio	0.83445318
91	MP0002229_neurodegeneration	0.82672891
92	MP0000538_abnormal_urinary_bladder	0.82502379
93	MP0002734_abnormal_mechanical_nocicepti	0.80607689
94	MP0005636_abnormal_mineral_homeostasis	0.77541757
95	MP0001765_abnormal_ion_homeostasis	0.76318118
96	MP0002067_abnormal_sensory_capabilities	0.76101930
97	MP0003137_abnormal_impulse_conducting	0.75602194
98	MP0000613_abnormal_salivary_gland	0.72949535
99	MP0000470_abnormal_stomach_morphology	0.72427130
100	MP0004085_abnormal_heartbeat	0.72215004

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08921271
2	Congenital stationary night blindness (HP:0007642)	4.06558088
3	Pancreatic fibrosis (HP:0100732)	3.85548520
4	Decreased central vision (HP:0007663)	3.82197258
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.64455274
6	True hermaphroditism (HP:0010459)	3.58774052
7	Molar tooth sign on MRI (HP:0002419)	3.40645506
8	Abnormality of midbrain morphology (HP:0002418)	3.40645506
9	Abnormality of the renal cortex (HP:0011035)	3.40202586
10	Gaze-evoked nystagmus (HP:0000640)	3.27175806
11	Hypothermia (HP:0002045)	3.21053903
12	Hyperventilation (HP:0002883)	3.17944349
13	Focal motor seizures (HP:0011153)	3.15413780
14	Nephronophthisis (HP:0000090)	3.14917854
15	Type II lissencephaly (HP:0007260)	3.14652250
16	Decreased circulating renin level (HP:0003351)	3.10930477
17	Hemiparesis (HP:0001269)	3.06752340
18	Attenuation of retinal blood vessels (HP:0007843)	3.04446527
19	Keratoconus (HP:0000563)	3.00333929
20	Increased corneal curvature (HP:0100692)	3.00333929
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.96847513
22	Abnormality of the renal medulla (HP:0100957)	2.84332691
23	Furrowed tongue (HP:0000221)	2.68962256
24	Methylmalonic acidemia (HP:0002912)	2.67976257
25	Abolished electroretinogram (ERG) (HP:0000550)	2.65581256
26	Intestinal atresia (HP:0011100)	2.60944931
27	Renal cortical cysts (HP:0000803)	2.56041498
28	Cystic liver disease (HP:0006706)	2.52101947
29	Thyroiditis (HP:0100646)	2.49847990
30	Medial flaring of the eyebrow (HP:0010747)	2.48926943
31	Chronic hepatic failure (HP:0100626)	2.48443175
32	Pendular nystagmus (HP:0012043)	2.46073690
33	Abnormal drinking behavior (HP:0030082)	2.42576559
34	Polydipsia (HP:0001959)	2.42576559
35	Large for gestational age (HP:0001520)	2.34256016
36	Tubular atrophy (HP:0000092)	2.33128765
37	Focal seizures (HP:0007359)	2.31733218
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29516650
39	Increased circulating renin level (HP:0000848)	2.24029449
40	Abnormality of vitamin B metabolism (HP:0004340)	2.15295856
41	Dialeptic seizures (HP:0011146)	2.15081003
42	Methylmalonic aciduria (HP:0012120)	2.09087955
43	Congenital sensorineural hearing impairment (HP:0008527)	2.08407402
44	Sclerocornea (HP:0000647)	2.06732091
45	Colon cancer (HP:0003003)	2.06491525
46	Bony spicule pigmentary retinopathy (HP:0007737)	2.05911596
47	3-Methylglutaconic aciduria (HP:0003535)	2.04544615
48	Ketoacidosis (HP:0001993)	2.03843557
49	Hematochezia (HP:0002573)	2.01000364
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00481863
51	Inability to walk (HP:0002540)	2.00252789
52	Cerebellar dysplasia (HP:0007033)	1.98304362
53	Thyroid-stimulating hormone excess (HP:0002925)	1.97789684
54	Stomach cancer (HP:0012126)	1.97492422
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96957552
56	Absent/shortened dynein arms (HP:0200106)	1.96957552
57	Increased CSF lactate (HP:0002490)	1.95906189
58	Severe muscular hypotonia (HP:0006829)	1.95644098
59	Congenital hepatic fibrosis (HP:0002612)	1.95506866
60	Broad-based gait (HP:0002136)	1.94934610
61	Progressive inability to walk (HP:0002505)	1.94782723
62	Widely spaced teeth (HP:0000687)	1.94192500
63	Febrile seizures (HP:0002373)	1.93879187
64	Male pseudohermaphroditism (HP:0000037)	1.90063751
65	Hyperkalemia (HP:0002153)	1.89751822
66	Mitochondrial inheritance (HP:0001427)	1.89594823
67	Hamartoma of the eye (HP:0010568)	1.89436844
68	Lissencephaly (HP:0001339)	1.88666687
69	Progressive macrocephaly (HP:0004481)	1.88651934
70	Pachygyria (HP:0001302)	1.86206779
71	Hepatic necrosis (HP:0002605)	1.86144498
72	Abnormality of renin-angiotensin system (HP:0000847)	1.84872408
73	Ketosis (HP:0001946)	1.84217222
74	Anencephaly (HP:0002323)	1.84166525
75	Polyuria (HP:0000103)	1.83436155
76	Ependymoma (HP:0002888)	1.80917863
77	Volvulus (HP:0002580)	1.79948047
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78734860
79	Neoplasm of the adrenal cortex (HP:0100641)	1.78499019
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77219009
81	Tongue fasciculations (HP:0001308)	1.76175377
82	Toxemia of pregnancy (HP:0100603)	1.73728247
83	Bile duct proliferation (HP:0001408)	1.73333146
84	Abnormal biliary tract physiology (HP:0012439)	1.73333146
85	Hypoglycemic coma (HP:0001325)	1.70665971
86	Congenital, generalized hypertrichosis (HP:0004540)	1.69942808
87	Progressive cerebellar ataxia (HP:0002073)	1.69600680
88	Dyskinesia (HP:0100660)	1.69465811
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.69161099
90	Hypoplasia of the fovea (HP:0007750)	1.69161099
91	Chorioretinal atrophy (HP:0000533)	1.68453368
92	Gait imbalance (HP:0002141)	1.67613431
93	Absence seizures (HP:0002121)	1.67520008
94	Severe visual impairment (HP:0001141)	1.67373334
95	Conjunctival hamartoma (HP:0100780)	1.67100641
96	Generalized myoclonic seizures (HP:0002123)	1.66728236
97	Postaxial foot polydactyly (HP:0001830)	1.65064184
98	Absent speech (HP:0001344)	1.64687015
99	Limb dystonia (HP:0002451)	1.63700076
100	Hyperactive renin-angiotensin system (HP:0000841)	1.62647454

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.01382756
2	BMPR1B	2.87146224
3	MAP4K2	2.82722724
4	ADRBK2	2.70243468
5	GRK1	2.33918647
6	NUAK1	2.32291800
7	CASK	2.20080750
8	WNK3	2.15364870
9	INSRR	2.03122523
10	WNK4	1.99243369
11	ACVR1B	1.98270428
12	FGFR2	1.95527901
13	PINK1	1.94194376
14	TAOK3	1.93929321
15	MAP2K6	1.92675573
16	DAPK2	1.83935821
17	ZAK	1.77197515
18	OXSR1	1.76654826
19	MAP3K4	1.67602950
20	MAPK13	1.62466728
21	STK39	1.60696355
22	MST4	1.57092347
23	PHKG2	1.56463985
24	PHKG1	1.56463985
25	PLK2	1.39104613
26	ERBB3	1.19770165
27	MARK1	1.16400396
28	PAK3	1.15950064
29	PRKCE	1.14171599
30	STK3	1.12845562
31	TXK	1.12298256
32	TRPM7	1.11881668
33	MAP2K7	1.09846136
34	TAF1	1.08473236
35	TIE1	1.04598640
36	TNIK	1.03656111
37	EIF2AK3	1.02332493
38	MKNK2	0.99285291
39	VRK2	0.96998041
40	TGFBR1	0.95459496
41	DYRK2	0.94077237
42	FER	0.90521935
43	TEC	0.88303629
44	MAPKAPK5	0.88248682
45	PNCK	0.88051999
46	NTRK3	0.86751391
47	ADRBK1	0.85611553
48	IKBKB	0.83099906
49	TLK1	0.79438676
50	CSNK1G1	0.78046332
51	ITK	0.75498694
52	KIT	0.73620637
53	MAPKAPK3	0.72110929
54	PTK2B	0.70972500
55	TNK2	0.70464104
56	CCNB1	0.70182564
57	PRKCG	0.68091561
58	VRK1	0.67006451
59	STK11	0.66211092
60	PRKCI	0.65612886
61	AKT3	0.62087824
62	CAMKK2	0.61450855
63	STK38L	0.60806162
64	CSNK1G2	0.60004038
65	NLK	0.59880588
66	PIK3CG	0.59579471
67	CSNK1G3	0.58763807
68	IRAK1	0.56684907
69	FGFR3	0.56649092
70	STK24	0.55107872
71	PLK3	0.54242165
72	PRKCQ	0.50245893
73	EIF2AK2	0.49723680
74	CAMK2A	0.48989234
75	PKN1	0.47590355
76	CSNK1D	0.46825783
77	GRK5	0.46149621
78	CAMK2D	0.45710255
79	EPHA4	0.44605327
80	PRKACA	0.43377135
81	PRKG1	0.42895490
82	OBSCN	0.41960162
83	CSNK1A1	0.41063766
84	PRKAA1	0.40769769
85	MAP2K1	0.40279764
86	MAP2K4	0.39186202
87	PRKAA2	0.39175806
88	MKNK1	0.39156971
89	MAP2K2	0.36260187
90	ABL1	0.35807080
91	RPS6KA5	0.35769740
92	CSNK1A1L	0.35760150
93	MUSK	0.35403159
94	WNK1	0.34729118
95	PRKCA	0.34084499
96	SGK1	0.33593207
97	PIK3CA	0.33286210
98	PRKCZ	0.32998701
99	BRSK2	0.30728900
100	EPHA3	0.30686230

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.27852293
2	Phototransduction_Homo sapiens_hsa04744	3.11646512
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.77256736
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43552531
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38130120
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.37306929
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.13219415
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04378269
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.95706524
10	Caffeine metabolism_Homo sapiens_hsa00232	1.91222699
11	Protein export_Homo sapiens_hsa03060	1.89210019
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82721802
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.81704387
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.80576131
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.78475602
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75286644
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67377451
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66992496
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65435968
20	Propanoate metabolism_Homo sapiens_hsa00640	1.56411029
21	Homologous recombination_Homo sapiens_hsa03440	1.56034622
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.55456287
23	One carbon pool by folate_Homo sapiens_hsa00670	1.54517126
24	Sulfur metabolism_Homo sapiens_hsa00920	1.46119205
25	Peroxisome_Homo sapiens_hsa04146	1.45415727
26	Insulin secretion_Homo sapiens_hsa04911	1.40649813
27	Olfactory transduction_Homo sapiens_hsa04740	1.36940631
28	Regulation of autophagy_Homo sapiens_hsa04140	1.34243635
29	ABC transporters_Homo sapiens_hsa02010	1.33481065
30	Retinol metabolism_Homo sapiens_hsa00830	1.28984387
31	Nicotine addiction_Homo sapiens_hsa05033	1.27818172
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26236024
33	RNA polymerase_Homo sapiens_hsa03020	1.22762300
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22454018
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22219694
36	Taste transduction_Homo sapiens_hsa04742	1.18895818
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17386765
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.16623225
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13622646
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12514311
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12425080
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11293669
43	RNA degradation_Homo sapiens_hsa03018	1.10284291
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.07500140
45	Basal transcription factors_Homo sapiens_hsa03022	1.04315756
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04061635
47	Circadian entrainment_Homo sapiens_hsa04713	1.00112470
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99883227
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99767228
50	Parkinsons disease_Homo sapiens_hsa05012	0.94285013
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94195575
52	Morphine addiction_Homo sapiens_hsa05032	0.94157946
53	Salivary secretion_Homo sapiens_hsa04970	0.92765954
54	Asthma_Homo sapiens_hsa05310	0.92175998
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89128574
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88871048
57	Circadian rhythm_Homo sapiens_hsa04710	0.88609036
58	Purine metabolism_Homo sapiens_hsa00230	0.83801961
59	Fatty acid elongation_Homo sapiens_hsa00062	0.83148646
60	Mineral absorption_Homo sapiens_hsa04978	0.81759029
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.81254682
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81134631
63	Serotonergic synapse_Homo sapiens_hsa04726	0.80633007
64	Renin secretion_Homo sapiens_hsa04924	0.80537698
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.78967488
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75323619
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71608944
68	GABAergic synapse_Homo sapiens_hsa04727	0.71403939
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69367226
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69313585
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67907494
72	Alzheimers disease_Homo sapiens_hsa05010	0.66133184
73	Histidine metabolism_Homo sapiens_hsa00340	0.65580160
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.64965391
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.63950061
76	Fatty acid degradation_Homo sapiens_hsa00071	0.63425391
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63030410
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61617071
79	Metabolic pathways_Homo sapiens_hsa01100	0.61025497
80	Long-term depression_Homo sapiens_hsa04730	0.57145353
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56197832
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53597025
83	Primary immunodeficiency_Homo sapiens_hsa05340	0.51636823
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50684759
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.50105824
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46421453
87	Allograft rejection_Homo sapiens_hsa05330	0.46155776
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46053999
89	Huntingtons disease_Homo sapiens_hsa05016	0.45747643
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44088653
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43853293
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43829480
93	Pancreatic secretion_Homo sapiens_hsa04972	0.42145679
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41610134
95	Graft-versus-host disease_Homo sapiens_hsa05332	0.41533436
96	Amphetamine addiction_Homo sapiens_hsa05031	0.40835568
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.38836690
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.37618292
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36692358
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35847712

ZNF662

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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