ZNF664

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.29290256
2COPI coating of Golgi vesicle (GO:0048205)4.29290256
3planar cell polarity pathway involved in neural tube closure (GO:0090179)3.61654895
4paraxial mesoderm development (GO:0048339)3.51598001
5nuclear pore complex assembly (GO:0051292)3.49383812
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40996142
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.40904652
8desmosome organization (GO:0002934)3.26578172
9apical protein localization (GO:0045176)3.26555777
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25866263
11protein retention in ER lumen (GO:0006621)3.24167412
12regulation of NFAT protein import into nucleus (GO:0051532)3.18746106
13regulation of RNA export from nucleus (GO:0046831)3.14643593
14regulation of glucose import in response to insulin stimulus (GO:2001273)3.13063001
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12320687
16embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02776377
17regulation of nucleobase-containing compound transport (GO:0032239)2.98719009
18nuclear pore organization (GO:0006999)2.96114800
19asymmetric protein localization (GO:0008105)2.88414358
20camera-type eye morphogenesis (GO:0048593)2.80759142
21mitotic sister chromatid cohesion (GO:0007064)2.75931099
22mitotic chromosome condensation (GO:0007076)2.73692424
23adherens junction assembly (GO:0034333)2.72657538
24establishment of apical/basal cell polarity (GO:0035089)2.71195708
25epithelial cell-cell adhesion (GO:0090136)2.70986577
26DNA unwinding involved in DNA replication (GO:0006268)2.70226582
27Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67618268
28embryonic camera-type eye morphogenesis (GO:0048596)2.67557568
29establishment or maintenance of bipolar cell polarity (GO:0061245)2.66557953
30establishment or maintenance of apical/basal cell polarity (GO:0035088)2.66557953
31bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63903444
32regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.60108829
33proline biosynthetic process (GO:0006561)2.59842219
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.59586644
35regulation of establishment of planar polarity (GO:0090175)2.59131924
36protein localization to microtubule (GO:0035372)2.58354515
37vesicle coating (GO:0006901)2.57179309
38notochord development (GO:0030903)2.56001921
39eye morphogenesis (GO:0048592)2.55814462
40embryonic eye morphogenesis (GO:0048048)2.54013002
41sodium ion export (GO:0071436)2.53661597
42maternal placenta development (GO:0001893)2.53584555
43ectodermal placode formation (GO:0060788)2.53255947
44RNA stabilization (GO:0043489)2.50826461
45mRNA stabilization (GO:0048255)2.50826461
46peptidyl-lysine dimethylation (GO:0018027)2.50283055
47histone H3-K9 demethylation (GO:0033169)2.49922567
48mating behavior (GO:0007617)2.47387426
49body morphogenesis (GO:0010171)2.46481384
50COPII vesicle coating (GO:0048208)2.45860461
51cell-substrate adherens junction assembly (GO:0007045)2.43885353
52focal adhesion assembly (GO:0048041)2.43885353
53hippo signaling (GO:0035329)2.41417119
54branching involved in mammary gland duct morphogenesis (GO:0060444)2.37966223
55layer formation in cerebral cortex (GO:0021819)2.36228044
56establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36169767
57cellular protein complex localization (GO:0034629)2.35268478
58pore complex assembly (GO:0046931)2.34726230
59semaphorin-plexin signaling pathway (GO:0071526)2.34483490
60regulation of translational fidelity (GO:0006450)2.32850778
61establishment of nucleus localization (GO:0040023)2.32794690
62activation of Rac GTPase activity (GO:0032863)2.31453503
63receptor recycling (GO:0001881)2.30754792
64ear development (GO:0043583)2.30315641
65establishment of monopolar cell polarity (GO:0061162)2.29837720
66establishment or maintenance of monopolar cell polarity (GO:0061339)2.29837720
67regulation of early endosome to late endosome transport (GO:2000641)2.28516393
68cellular response to prostaglandin stimulus (GO:0071379)2.27630384
69regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.27517548
70insulin-like growth factor receptor signaling pathway (GO:0048009)2.27474941
71cellular response to epidermal growth factor stimulus (GO:0071364)2.25848340
72response to epidermal growth factor (GO:0070849)2.25161286
73nucleosome disassembly (GO:0006337)2.24024760
74protein-DNA complex disassembly (GO:0032986)2.24024760
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.23145704
76negative regulation of catenin import into nucleus (GO:0035414)2.22951848
77vitamin transmembrane transport (GO:0035461)2.19751232
78convergent extension (GO:0060026)2.19239587
79NADH metabolic process (GO:0006734)2.17717398
80positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.17261761
81embryonic foregut morphogenesis (GO:0048617)2.15522085
82regulation of cardioblast differentiation (GO:0051890)2.15461659
83positive regulation of glucose import (GO:0046326)2.14638787
84establishment of tissue polarity (GO:0007164)2.13706496
85establishment of planar polarity (GO:0001736)2.13706496
86cell-substrate junction assembly (GO:0007044)2.13230007
87epithelial cell differentiation involved in prostate gland development (GO:0060742)2.11388617
88NLS-bearing protein import into nucleus (GO:0006607)2.11066555
89axonemal dynein complex assembly (GO:0070286)2.11009874
90surfactant homeostasis (GO:0043129)2.10901000
91regulation of transforming growth factor beta2 production (GO:0032909)2.10314709
92positive regulation of cellular response to insulin stimulus (GO:1900078)2.10159486
93non-canonical Wnt signaling pathway (GO:0035567)2.10140171
94cochlea morphogenesis (GO:0090103)2.10120445
95stress granule assembly (GO:0034063)2.10080693
96hemidesmosome assembly (GO:0031581)2.07924540
97cell communication by electrical coupling (GO:0010644)2.07838711
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.06620277
99regulation of fatty acid beta-oxidation (GO:0031998)2.06556090
100positive regulation of glucose transport (GO:0010828)2.05746181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.58897526
2CLOCK_20551151_ChIP-Seq_293T_Human2.86736882
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86165155
4AR_21909140_ChIP-Seq_LNCAP_Human2.82588942
5E2F7_22180533_ChIP-Seq_HELA_Human2.48543531
6ZNF263_19887448_ChIP-Seq_K562_Human2.47854931
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.36837927
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33085551
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.33051592
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.32545527
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30218966
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20032329
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.16081069
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.14186508
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11730846
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09398301
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.06663244
18RACK7_27058665_Chip-Seq_MCF-7_Human1.97648996
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91310409
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89102544
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.88775833
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80879676
23* KDM2B_26808549_Chip-Seq_K562_Human1.78479621
24DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76639909
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75533541
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72332698
27* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71779264
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69822815
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69430605
30* RUNX1_27514584_Chip-Seq_MCF-7_Human1.60352882
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.59521576
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56299336
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54404908
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53902803
35CHD1_26751641_Chip-Seq_LNCaP_Human1.53146232
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52046969
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.50470790
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48143804
39TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45945499
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44900865
41* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44857204
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42662126
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.42574838
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42143366
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40912948
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40080948
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38433634
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38201874
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36664942
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29249930
51CREB1_26743006_Chip-Seq_LNCaP_Human1.28452699
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.26724239
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26078422
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24784008
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24640315
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24634926
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23780136
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22009062
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21824619
60LXR_22292898_ChIP-Seq_THP-1_Human1.21592427
61TCF7_22412390_ChIP-Seq_EML_Mouse1.21150004
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20736137
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19048354
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18757910
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18281023
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.17927050
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17117229
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.14786639
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14423439
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.14148236
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.14148236
72GATA6_25053715_ChIP-Seq_YYC3_Human1.13514189
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13377047
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.13103979
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.12435470
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.10656096
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09950216
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08370001
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07549901
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07549901
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.06386371
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06200718
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.05282133
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04745852
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04637824
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03264878
87ATF3_27146783_Chip-Seq_COLON_Human1.01875991
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01770465
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00844126
90AHR_22903824_ChIP-Seq_MCF-7_Human1.00775173
91* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99560327
92MYC_22102868_ChIP-Seq_BL_Human0.98948366
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98435160
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.97774018
95* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97369728
96* KDM2B_26808549_Chip-Seq_JURKAT_Human0.95684044
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95507713
98KDM2B_26808549_Chip-Seq_DND41_Human0.94460360
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93382967
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93013401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.53714061
2MP0003705_abnormal_hypodermis_morpholog3.43984748
3MP0005409_darkened_coat_color2.83242165
4MP0000537_abnormal_urethra_morphology2.78247881
5MP0004264_abnormal_extraembryonic_tissu2.35194078
6MP0000566_synostosis2.29951965
7MP0004185_abnormal_adipocyte_glucose2.26030278
8MP0009780_abnormal_chondrocyte_physiolo2.22026827
9MP0002009_preneoplasia2.12976831
10MP0002877_abnormal_melanocyte_morpholog2.10511068
11MP0010352_gastrointestinal_tract_polyps2.08265346
12MP0005076_abnormal_cell_differentiation2.08059332
13MP0000678_abnormal_parathyroid_gland1.75528708
14MP0002249_abnormal_larynx_morphology1.69667880
15MP0010678_abnormal_skin_adnexa1.66864232
16MP0000534_abnormal_ureter_morphology1.66486406
17MP0004858_abnormal_nervous_system1.66036506
18MP0005666_abnormal_adipose_tissue1.65190477
19MP0009053_abnormal_anal_canal1.59276212
20MP0004233_abnormal_muscle_weight1.58993561
21MP0005623_abnormal_meninges_morphology1.56360376
22MP0004782_abnormal_surfactant_physiolog1.52084648
23MP0005248_abnormal_Harderian_gland1.51813786
24MP0001346_abnormal_lacrimal_gland1.48758505
25MP0003941_abnormal_skin_development1.46133094
26MP0003942_abnormal_urinary_system1.45883527
27MP0003123_paternal_imprinting1.43198310
28MP0003566_abnormal_cell_adhesion1.41916443
29MP0000579_abnormal_nail_morphology1.40564077
30MP0000462_abnormal_digestive_system1.39809574
31MP0002098_abnormal_vibrissa_morphology1.39278862
32MP0001849_ear_inflammation1.37229306
33MP0002796_impaired_skin_barrier1.36654472
34MP0009672_abnormal_birth_weight1.35861786
35MP0002697_abnormal_eye_size1.34943169
36MP0002909_abnormal_adrenal_gland1.34378554
37MP0000383_abnormal_hair_follicle1.32574395
38MP0003890_abnormal_embryonic-extraembry1.30423781
39MP0005257_abnormal_intraocular_pressure1.29301461
40MP0000762_abnormal_tongue_morphology1.27599168
41MP0001730_embryonic_growth_arrest1.27581904
42MP0002084_abnormal_developmental_patter1.25489488
43MP0010030_abnormal_orbit_morphology1.25460785
44MP0002896_abnormal_bone_mineralization1.23681620
45MP0003115_abnormal_respiratory_system1.22105319
46MP0003385_abnormal_body_wall1.16171758
47MP0002822_catalepsy1.14368828
48MP0002092_abnormal_eye_morphology1.11475939
49MP0005187_abnormal_penis_morphology1.11213612
50MP0002085_abnormal_embryonic_tissue1.11042517
51MP0004272_abnormal_basement_membrane1.11036216
52MP0003937_abnormal_limbs/digits/tail_de1.10650549
53MP0005380_embryogenesis_phenotype1.09892579
54MP0001672_abnormal_embryogenesis/_devel1.09892579
55MP0005375_adipose_tissue_phenotype1.09665571
56MP0003315_abnormal_perineum_morphology1.09441361
57MP0009379_abnormal_foot_pigmentation1.09096614
58MP0003984_embryonic_growth_retardation1.08435399
59MP0003453_abnormal_keratinocyte_physiol1.07799965
60MP0000733_abnormal_muscle_development1.07465546
61MP0003868_abnormal_feces_composition1.07376197
62MP0000428_abnormal_craniofacial_morphol1.05776477
63MP0003861_abnormal_nervous_system1.05463333
64MP0002088_abnormal_embryonic_growth/wei1.04280061
65MP0003935_abnormal_craniofacial_develop1.03104861
66MP0000467_abnormal_esophagus_morphology0.99872307
67MP0000377_abnormal_hair_follicle0.99780269
68MP0002089_abnormal_postnatal_growth/wei0.99666785
69MP0005501_abnormal_skin_physiology0.99170345
70MP0006138_congestive_heart_failure0.98570477
71MP0009703_decreased_birth_body0.98501701
72MP0002086_abnormal_extraembryonic_tissu0.96050305
73MP0000003_abnormal_adipose_tissue0.94208519
74MP0000778_abnormal_nervous_system0.94062643
75MP0001666_abnormal_nutrient_absorption0.92612080
76MP0000432_abnormal_head_morphology0.91412974
77MP0000627_abnormal_mammary_gland0.91208322
78MP0001299_abnormal_eye_distance/0.91085665
79MP0010630_abnormal_cardiac_muscle0.91041507
80MP0002116_abnormal_craniofacial_bone0.90796313
81MP0003091_abnormal_cell_migration0.90006795
82MP0004197_abnormal_fetal_growth/weight/0.88904154
83MP0004270_analgesia0.87233175
84MP0004957_abnormal_blastocyst_morpholog0.87176693
85MP0000350_abnormal_cell_proliferation0.85951752
86MP0003693_abnormal_embryo_hatching0.85225336
87MP0002080_prenatal_lethality0.84605124
88MP0001348_abnormal_lacrimal_gland0.84585568
89MP0002233_abnormal_nose_morphology0.84140335
90MP0003755_abnormal_palate_morphology0.82728840
91MP0001697_abnormal_embryo_size0.82405186
92MP0000681_abnormal_thyroid_gland0.80136821
93MP0005451_abnormal_body_composition0.78685812
94MP0003283_abnormal_digestive_organ0.78094210
95MP0003119_abnormal_digestive_system0.76570936
96MP0008932_abnormal_embryonic_tissue0.74754246
97MP0002971_abnormal_brown_adipose0.72859905
98MP0002081_perinatal_lethality0.71507432
99MP0003634_abnormal_glial_cell0.70225078
100MP0003938_abnormal_ear_development0.70131209

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.22934563
2Flat acetabular roof (HP:0003180)3.03717059
3Asymmetry of the thorax (HP:0001555)3.03541844
4Right ventricular cardiomyopathy (HP:0011663)2.61362337
5Hyperparathyroidism (HP:0000843)2.45065288
6Insomnia (HP:0100785)2.43914586
7Vertebral arch anomaly (HP:0008438)2.43050580
8Termporal pattern (HP:0011008)2.40557938
9Insidious onset (HP:0003587)2.40557938
10Abnormality of the distal phalanx of the thumb (HP:0009617)2.36641877
11Macroorchidism (HP:0000053)2.34989910
12Missing ribs (HP:0000921)2.31123683
13Germ cell neoplasia (HP:0100728)2.25903256
14Ankyloglossia (HP:0010296)2.24938241
15Arterial tortuosity (HP:0005116)2.20926653
16Increased nuchal translucency (HP:0010880)2.14635038
17Renovascular hypertension (HP:0100817)2.07895640
18Overriding aorta (HP:0002623)2.07699981
19Protrusio acetabuli (HP:0003179)2.06647034
20Elfin facies (HP:0004428)2.00077125
21Papillary thyroid carcinoma (HP:0002895)1.98581135
22Abnormality of the phalanges of the hallux (HP:0010057)1.98321604
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97818984
24Abnormality of the gastric mucosa (HP:0004295)1.94770074
25Dysmetric saccades (HP:0000641)1.94598973
26Shallow orbits (HP:0000586)1.93943719
27Short nail (HP:0001799)1.92124058
28Back pain (HP:0003418)1.90181746
29High anterior hairline (HP:0009890)1.89429484
30Arnold-Chiari malformation (HP:0002308)1.89281211
31Pseudobulbar signs (HP:0002200)1.88354360
32Vascular tortuosity (HP:0004948)1.85838192
33Obstructive sleep apnea (HP:0002870)1.84123277
34Ulnar bowing (HP:0003031)1.83958125
35Thin bony cortex (HP:0002753)1.83313595
36Broad face (HP:0000283)1.82089717
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81533748
38Heterotopia (HP:0002282)1.80225902
39Renal duplication (HP:0000075)1.80220948
40Advanced eruption of teeth (HP:0006288)1.79952306
41Curly hair (HP:0002212)1.79498609
42Abnormality of the distal phalanges of the toes (HP:0010182)1.77333954
43Patellar dislocation (HP:0002999)1.77285288
44Deep philtrum (HP:0002002)1.74599094
45Bell-shaped thorax (HP:0001591)1.72876262
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70859200
47Hypercalcemia (HP:0003072)1.68618699
48Turricephaly (HP:0000262)1.68084222
49Precocious puberty (HP:0000826)1.66300971
50Atelectasis (HP:0100750)1.66021772
51Abnormality of permanent molar morphology (HP:0011071)1.65589559
52Abnormality of the dental root (HP:0006486)1.65589559
53Taurodontia (HP:0000679)1.65589559
54Hypercortisolism (HP:0001578)1.64991081
55Septate vagina (HP:0001153)1.64271549
56Relative macrocephaly (HP:0004482)1.63934933
57Hyperphosphatemia (HP:0002905)1.63369918
58Sparse lateral eyebrow (HP:0005338)1.62409588
59Spinal cord compression (HP:0002176)1.62149345
60Hammertoe (HP:0001765)1.62145063
61Obsessive-compulsive behavior (HP:0000722)1.61648331
62Syringomyelia (HP:0003396)1.60939768
63Spinal cord lesions (HP:0100561)1.60939768
64Metaphyseal cupping (HP:0003021)1.60330368
65Deviation of the thumb (HP:0009603)1.58955451
66Abnormality of the calcaneus (HP:0008364)1.57540192
67Male infertility (HP:0003251)1.55799618
68Broad palm (HP:0001169)1.55779146
69Abnormality of oral frenula (HP:0000190)1.55761700
70Cubitus valgus (HP:0002967)1.55734470
71Aplasia involving bones of the extremities (HP:0009825)1.55008889
72Aplasia involving bones of the upper limbs (HP:0009823)1.55008889
73Aplasia of the phalanges of the hand (HP:0009802)1.55008889
74Abnormality of molar (HP:0011077)1.53041057
75Abnormality of molar morphology (HP:0011070)1.53041057
76Disproportionate tall stature (HP:0001519)1.52860347
77Pheochromocytoma (HP:0002666)1.52287966
78Bundle branch block (HP:0011710)1.51483338
79Rhizomelia (HP:0008905)1.51406627
80Abnormality of carpal bone ossification (HP:0006257)1.51285746
81Bifid scrotum (HP:0000048)1.51130172
82Congenital glaucoma (HP:0001087)1.50574178
83Overlapping toe (HP:0001845)1.50115603
84Growth hormone excess (HP:0000845)1.48635393
85Exostoses (HP:0100777)1.48470528
86Abnormal ossification of hand bones (HP:0005921)1.48144648
87Mildly elevated creatine phosphokinase (HP:0008180)1.47910410
88Unilateral renal agenesis (HP:0000122)1.47792945
89Distal upper limb amyotrophy (HP:0007149)1.47063935
90Upper limb amyotrophy (HP:0009129)1.47063935
91Hyperactive renin-angiotensin system (HP:0000841)1.47046392
92Partial duplication of thumb phalanx (HP:0009944)1.46992272
93Subaortic stenosis (HP:0001682)1.45550189
94Abnormality of the left ventricular outflow tract (HP:0011103)1.45550189
95Absent frontal sinuses (HP:0002688)1.45437555
96Bronchomalacia (HP:0002780)1.45392856
97Bowel incontinence (HP:0002607)1.45143667
9811 pairs of ribs (HP:0000878)1.44395526
99Open mouth (HP:0000194)1.44216686
100Proximal placement of thumb (HP:0009623)1.44035654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12519063
2EEF2K3.26424197
3ICK3.06984828
4CDK122.75475712
5LATS22.51953124
6EPHA22.51316919
7MST1R2.47565698
8RIPK12.44051373
9PDGFRA2.36273710
10SCYL22.33543618
11MAP3K102.30215220
12LATS12.15527922
13SMG12.12064722
14MET2.11092516
15PKN22.09611508
16PNCK2.04108067
17SIK11.96157653
18NTRK11.60951732
19CAMK1G1.54671733
20FGFR41.51075154
21PRKD31.50010964
22MTOR1.33244059
23PTK21.26497810
24RPS6KB21.25202376
25KSR21.21776265
26BRD41.19813898
27RET1.17547059
28PRPF4B1.16396865
29MAP3K21.09734194
30TYRO31.05813790
31LMTK21.03174635
32EIF2AK11.00516971
33CDK61.00145821
34CAMK1D0.99720392
35PTK60.99645122
36NEK60.98153920
37TTK0.97559265
38PDGFRB0.97324925
39DMPK0.96563042
40KSR10.95407861
41EPHB20.94728392
42TESK10.93812921
43AKT30.87472758
44MAP3K90.86000382
45PAK40.84117526
46STK38L0.80556158
47MAPK150.78321960
48LRRK20.76642831
49CDK70.76161753
50IRAK30.75690518
51BCR0.74120609
52NEK90.72679335
53SGK30.70727837
54FGFR30.69917332
55DDR20.68777538
56TTN0.68229236
57BMX0.66994538
58YES10.65888847
59STK390.65516741
60AKT20.65097289
61MARK20.60527760
62STK380.59233495
63RPS6KB10.59037927
64PAK20.57918411
65PBK0.57262967
66RPS6KA20.56287107
67MAPK100.55767159
68ILK0.53550577
69PDPK10.53278650
70MAP2K20.52669277
71TSSK60.52030937
72STK240.50252260
73WNK10.50062937
74ALK0.49597753
75STK30.49432893
76FGFR10.48346362
77DYRK1B0.48260757
78ERBB40.47595668
79CSNK1E0.47325070
80ERBB30.47035064
81MARK10.42910240
82CASK0.42863124
83CDK150.42276841
84ERBB20.42040112
85FGFR20.41955013
86CHEK10.41836927
87CDK180.41730346
88CDK11A0.41465201
89BRAF0.40543761
90ARAF0.40133931
91NEK20.39515665
92CDK10.37748927
93PIK3CA0.37268426
94ROCK20.36713238
95MAP2K10.36611514
96UHMK10.36502591
97CAMKK10.36390093
98PASK0.35895191
99CDK20.35885950
100FER0.35701776

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052161.95539314
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95019184
3Adherens junction_Homo sapiens_hsa045201.89022928
4Endometrial cancer_Homo sapiens_hsa052131.80973994
5Chronic myeloid leukemia_Homo sapiens_hsa052201.71342946
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65133671
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.59450304
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48922726
9ErbB signaling pathway_Homo sapiens_hsa040121.47362542
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43776209
11Phenylalanine metabolism_Homo sapiens_hsa003601.39948165
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38734557
13Non-small cell lung cancer_Homo sapiens_hsa052231.38184732
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.37021949
15Renal cell carcinoma_Homo sapiens_hsa052111.35396319
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31909337
17Hippo signaling pathway_Homo sapiens_hsa043901.30055482
18Tight junction_Homo sapiens_hsa045301.28902735
19Notch signaling pathway_Homo sapiens_hsa043301.28124356
20Insulin signaling pathway_Homo sapiens_hsa049101.27618085
21Glioma_Homo sapiens_hsa052141.27612481
22Pancreatic cancer_Homo sapiens_hsa052121.25658551
23AMPK signaling pathway_Homo sapiens_hsa041521.23908318
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.22492530
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20186804
26Prostate cancer_Homo sapiens_hsa052151.20160198
27Choline metabolism in cancer_Homo sapiens_hsa052311.18563847
28Arginine biosynthesis_Homo sapiens_hsa002201.17438051
29Fatty acid biosynthesis_Homo sapiens_hsa000611.15134197
30Proteoglycans in cancer_Homo sapiens_hsa052051.13673234
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13116699
32Estrogen signaling pathway_Homo sapiens_hsa049151.13103362
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11045877
34Thyroid hormone synthesis_Homo sapiens_hsa049181.10278951
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10250036
36mTOR signaling pathway_Homo sapiens_hsa041501.08545567
37Bladder cancer_Homo sapiens_hsa052191.08103050
38Focal adhesion_Homo sapiens_hsa045101.07874343
39VEGF signaling pathway_Homo sapiens_hsa043701.05883258
40Prion diseases_Homo sapiens_hsa050201.05587433
41Bile secretion_Homo sapiens_hsa049761.05556739
42Lysine degradation_Homo sapiens_hsa003101.04808387
43Small cell lung cancer_Homo sapiens_hsa052221.04047912
44Histidine metabolism_Homo sapiens_hsa003401.03308550
45MicroRNAs in cancer_Homo sapiens_hsa052061.02904136
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02536193
47Colorectal cancer_Homo sapiens_hsa052101.00015631
48ECM-receptor interaction_Homo sapiens_hsa045120.98036100
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97837875
50mRNA surveillance pathway_Homo sapiens_hsa030150.96669482
51Melanogenesis_Homo sapiens_hsa049160.95683556
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95444615
53Basal cell carcinoma_Homo sapiens_hsa052170.95128701
54Axon guidance_Homo sapiens_hsa043600.94551477
55Inositol phosphate metabolism_Homo sapiens_hsa005620.92296902
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.91500417
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89378788
58Protein digestion and absorption_Homo sapiens_hsa049740.88287578
59Biosynthesis of amino acids_Homo sapiens_hsa012300.87502719
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86436021
61Long-term potentiation_Homo sapiens_hsa047200.86345018
62Gap junction_Homo sapiens_hsa045400.84725926
63Prolactin signaling pathway_Homo sapiens_hsa049170.82642209
64Dilated cardiomyopathy_Homo sapiens_hsa054140.81254913
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80874188
66Arginine and proline metabolism_Homo sapiens_hsa003300.79603784
67Glucagon signaling pathway_Homo sapiens_hsa049220.79362079
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.78460527
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77925163
70Wnt signaling pathway_Homo sapiens_hsa043100.76295153
71Hedgehog signaling pathway_Homo sapiens_hsa043400.76142340
72Insulin resistance_Homo sapiens_hsa049310.74943219
73PPAR signaling pathway_Homo sapiens_hsa033200.73794423
74GnRH signaling pathway_Homo sapiens_hsa049120.73263405
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71957639
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71210992
77Renin-angiotensin system_Homo sapiens_hsa046140.70161019
78Cell cycle_Homo sapiens_hsa041100.67370841
79Acute myeloid leukemia_Homo sapiens_hsa052210.67083358
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67071787
81Fatty acid metabolism_Homo sapiens_hsa012120.64225407
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.63821062
83Amoebiasis_Homo sapiens_hsa051460.61451680
84Melanoma_Homo sapiens_hsa052180.61323087
85Fructose and mannose metabolism_Homo sapiens_hsa000510.61094706
86Pyruvate metabolism_Homo sapiens_hsa006200.60439489
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60320435
88Tyrosine metabolism_Homo sapiens_hsa003500.60291863
89Pathways in cancer_Homo sapiens_hsa052000.59657612
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59481269
91TGF-beta signaling pathway_Homo sapiens_hsa043500.59237431
92Type II diabetes mellitus_Homo sapiens_hsa049300.58926187
93Carbon metabolism_Homo sapiens_hsa012000.58113846
94Vibrio cholerae infection_Homo sapiens_hsa051100.57668896
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57436490
96Pentose phosphate pathway_Homo sapiens_hsa000300.56937038
97Vitamin B6 metabolism_Homo sapiens_hsa007500.56840161
98Vitamin digestion and absorption_Homo sapiens_hsa049770.56339592
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55727416
100Fat digestion and absorption_Homo sapiens_hsa049750.55313244

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