ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.38227670
2	fucose catabolic process (GO:0019317)	4.57978239
3	L-fucose metabolic process (GO:0042354)	4.57978239
4	L-fucose catabolic process (GO:0042355)	4.57978239
5	indole-containing compound catabolic process (GO:0042436)	4.14072010
6	indolalkylamine catabolic process (GO:0046218)	4.14072010
7	tryptophan catabolic process (GO:0006569)	4.14072010
8	kynurenine metabolic process (GO:0070189)	4.10475557
9	DNA deamination (GO:0045006)	4.01466997
10	indolalkylamine metabolic process (GO:0006586)	3.99565597
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.74443224
12	tryptophan metabolic process (GO:0006568)	3.67496386
13	response to pheromone (GO:0019236)	3.67426174
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.61441696
15	cellular ketone body metabolic process (GO:0046950)	3.45628021
16	rRNA catabolic process (GO:0016075)	3.33519548
17	negative regulation of mast cell activation (GO:0033004)	3.31992466
18	protein-cofactor linkage (GO:0018065)	3.30400800
19	negative regulation of telomere maintenance (GO:0032205)	3.29778566
20	protein complex biogenesis (GO:0070271)	3.27780370
21	platelet dense granule organization (GO:0060155)	3.26557940
22	axoneme assembly (GO:0035082)	3.21859177
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.17111204
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.17111204
25	NADH dehydrogenase complex assembly (GO:0010257)	3.17111204
26	sulfation (GO:0051923)	3.15458665
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13661013
28	ketone body metabolic process (GO:1902224)	3.12209450
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10996087
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.08323818
31	detection of light stimulus involved in visual perception (GO:0050908)	3.08323818
32	maturation of 5.8S rRNA (GO:0000460)	3.08298195
33	respiratory chain complex IV assembly (GO:0008535)	3.07297054
34	pyrimidine nucleobase catabolic process (GO:0006208)	3.04296933
35	piRNA metabolic process (GO:0034587)	3.03048637
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99806965
37	indole-containing compound metabolic process (GO:0042430)	2.96549156
38	neural tube formation (GO:0001841)	2.95891438
39	preassembly of GPI anchor in ER membrane (GO:0016254)	2.93738815
40	epithelial cilium movement (GO:0003351)	2.93188882
41	protein polyglutamylation (GO:0018095)	2.90954537
42	reciprocal meiotic recombination (GO:0007131)	2.89482256
43	reciprocal DNA recombination (GO:0035825)	2.89482256
44	behavioral response to ethanol (GO:0048149)	2.85617194
45	ubiquinone biosynthetic process (GO:0006744)	2.82754560
46	cytochrome complex assembly (GO:0017004)	2.82705820
47	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.77941844
48	mannosylation (GO:0097502)	2.77411827
49	replication fork processing (GO:0031297)	2.76752624
50	retinal cone cell development (GO:0046549)	2.76340693
51	somite development (GO:0061053)	2.75416654
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.72734330
53	regulation of action potential (GO:0098900)	2.71954313
54	nonmotile primary cilium assembly (GO:0035058)	2.70373998
55	cellular biogenic amine catabolic process (GO:0042402)	2.69197630
56	amine catabolic process (GO:0009310)	2.69197630
57	kidney morphogenesis (GO:0060993)	2.69116535
58	nucleobase catabolic process (GO:0046113)	2.65548533
59	ubiquinone metabolic process (GO:0006743)	2.65523417
60	reflex (GO:0060004)	2.63852352
61	cornea development in camera-type eye (GO:0061303)	2.63831354
62	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.63284737
63	male meiosis I (GO:0007141)	2.63281023
64	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.62229279
65	recombinational repair (GO:0000725)	2.61167719
66	nephron tubule morphogenesis (GO:0072078)	2.60675461
67	nephron epithelium morphogenesis (GO:0072088)	2.60675461
68	double-strand break repair via homologous recombination (GO:0000724)	2.60392277
69	cilium morphogenesis (GO:0060271)	2.57736711
70	rhodopsin mediated signaling pathway (GO:0016056)	2.56279517
71	cellular response to ATP (GO:0071318)	2.55219513
72	photoreceptor cell maintenance (GO:0045494)	2.54791243
73	fucosylation (GO:0036065)	2.54642082
74	protein localization to cilium (GO:0061512)	2.54157350
75	protein K11-linked deubiquitination (GO:0035871)	2.52809243
76	gamma-aminobutyric acid transport (GO:0015812)	2.52689396
77	neuronal action potential (GO:0019228)	2.50969157
78	regulation of glucokinase activity (GO:0033131)	2.47229579
79	regulation of hexokinase activity (GO:1903299)	2.47229579
80	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.45963180
81	regulation of cilium movement (GO:0003352)	2.45456846
82	photoreceptor cell development (GO:0042461)	2.45265700
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.44922924
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.44922924
85	regulation of hippo signaling (GO:0035330)	2.44873590
86	multicellular organism reproduction (GO:0032504)	2.44186146
87	synaptic transmission, cholinergic (GO:0007271)	2.44161602
88	cilium organization (GO:0044782)	2.44139669
89	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43521313
90	regulation of mesoderm development (GO:2000380)	2.43273373
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.43233085
92	positive regulation of fatty acid transport (GO:2000193)	2.43211633
93	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.42135465
94	positive regulation of defense response to virus by host (GO:0002230)	2.40657621
95	amino acid salvage (GO:0043102)	2.39394082
96	L-methionine salvage (GO:0071267)	2.39394082
97	L-methionine biosynthetic process (GO:0071265)	2.39394082
98	primary amino compound metabolic process (GO:1901160)	2.39272657
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.38986320
100	DNA methylation involved in gamete generation (GO:0043046)	2.38799092

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.20961192
2	VDR_22108803_ChIP-Seq_LS180_Human	3.45470690
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.94465724
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78198826
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76668120
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.71183558
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51541423
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35890197
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22603516
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.18836403
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15567909
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11218554
13	FUS_26573619_Chip-Seq_HEK293_Human	2.10416267
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10343014
15	EWS_26573619_Chip-Seq_HEK293_Human	2.09429490
16	P300_19829295_ChIP-Seq_ESCs_Human	1.97046634
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91896211
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87177250
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86936710
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86622230
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.81423800
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.79255845
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77510498
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71250818
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71104898
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67168135
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63575369
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62449473
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62123552
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.56816027
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.55501564
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55212692
33	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52844700
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52417033
35	* MYC_18940864_ChIP-ChIP_HL60_Human	1.52045827
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50628816
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48363988
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47680714
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45332073
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44967821
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.43132741
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43132741
43	STAT3_23295773_ChIP-Seq_U87_Human	1.40870529
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39302858
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39302858
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38195272
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36880278
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36880278
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36775293
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35887165
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35448204
52	AR_25329375_ChIP-Seq_VCAP_Human	1.34765876
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33675556
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33502809
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33502809
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33350850
57	TCF4_23295773_ChIP-Seq_U87_Human	1.32823706
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31558549
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30525877
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.30383139
61	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28625474
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26248332
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24440915
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24178461
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23760168
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23607461
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23087153
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22103931
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20649801
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20587727
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20170523
72	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19834693
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19336761
74	NCOR_22424771_ChIP-Seq_293T_Human	1.17639407
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.15960154
76	AR_20517297_ChIP-Seq_VCAP_Human	1.15882882
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15745091
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14912075
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13534096
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13073407
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12092057
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08834041
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07435438
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04273588
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03257239
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02483987
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02412494
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02379335
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01494412
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00992084
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00221739
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99319833
93	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99094994
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99071463
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98314952
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97470589
97	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.97448654
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94133016
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91222861
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.90769568

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.78159524
2	MP0008877_abnormal_DNA_methylation	2.70198622
3	MP0003136_yellow_coat_color	2.56848320
4	MP0002102_abnormal_ear_morphology	2.53942793
5	MP0002876_abnormal_thyroid_physiology	2.44009201
6	MP0005551_abnormal_eye_electrophysiolog	2.39694845
7	MP0001968_abnormal_touch/_nociception	2.32823559
8	MP0004043_abnormal_pH_regulation	2.22327962
9	MP0006292_abnormal_olfactory_placode	2.21034773
10	MP0008872_abnormal_physiological_respon	2.19513901
11	MP0002837_dystrophic_cardiac_calcinosis	2.15503680
12	MP0003646_muscle_fatigue	2.07039419
13	MP0008875_abnormal_xenobiotic_pharmacok	2.00149379
14	MP0006072_abnormal_retinal_apoptosis	1.97599035
15	MP0004142_abnormal_muscle_tone	1.96841000
16	MP0002736_abnormal_nociception_after	1.93720872
17	MP0009745_abnormal_behavioral_response	1.86555377
18	MP0005646_abnormal_pituitary_gland	1.85278204
19	MP0000569_abnormal_digit_pigmentation	1.84733651
20	MP0003011_delayed_dark_adaptation	1.81260596
21	MP0005084_abnormal_gallbladder_morpholo	1.80837643
22	MP0004885_abnormal_endolymph	1.77817810
23	MP0002638_abnormal_pupillary_reflex	1.77278424
24	MP0003787_abnormal_imprinting	1.76367798
25	MP0000372_irregular_coat_pigmentation	1.75765586
26	MP0001986_abnormal_taste_sensitivity	1.73882881
27	MP0004133_heterotaxia	1.71029361
28	MP0002653_abnormal_ependyma_morphology	1.68635523
29	MP0005253_abnormal_eye_physiology	1.65505610
30	MP0009046_muscle_twitch	1.63141335
31	MP0000631_abnormal_neuroendocrine_gland	1.58641498
32	MP0002938_white_spotting	1.58037182
33	MP0002272_abnormal_nervous_system	1.57290408
34	MP0005645_abnormal_hypothalamus_physiol	1.56154680
35	MP0001501_abnormal_sleep_pattern	1.55940160
36	MP0000427_abnormal_hair_cycle	1.51472619
37	MP0006276_abnormal_autonomic_nervous	1.51364008
38	MP0001485_abnormal_pinna_reflex	1.46793295
39	MP0005174_abnormal_tail_pigmentation	1.45195095
40	MP0003880_abnormal_central_pattern	1.44987926
41	MP0002928_abnormal_bile_duct	1.40805267
42	MP0005075_abnormal_melanosome_morpholog	1.38108129
43	MP0001486_abnormal_startle_reflex	1.37231961
44	MP0002735_abnormal_chemical_nociception	1.36280018
45	MP0002163_abnormal_gland_morphology	1.33282904
46	MP0002277_abnormal_respiratory_mucosa	1.29685267
47	MP0002138_abnormal_hepatobiliary_system	1.27189577
48	MP0001984_abnormal_olfaction	1.26467498
49	MP0005389_reproductive_system_phenotype	1.24658183
50	MP0002160_abnormal_reproductive_system	1.21169140
51	MP0001919_abnormal_reproductive_system	1.21094064
52	MP0002733_abnormal_thermal_nociception	1.20827934
53	MP0001905_abnormal_dopamine_level	1.19599468
54	MP0002064_seizures	1.19500644
55	MP0002572_abnormal_emotion/affect_behav	1.19209765
56	MP0004147_increased_porphyrin_level	1.18672908
57	MP0001970_abnormal_pain_threshold	1.16029910
58	MP0004145_abnormal_muscle_electrophysio	1.15167971
59	MP0003718_maternal_effect	1.14756610
60	MP0005377_hearing/vestibular/ear_phenot	1.10701644
61	MP0003878_abnormal_ear_physiology	1.10701644
62	MP0003252_abnormal_bile_duct	1.06713877
63	MP0000383_abnormal_hair_follicle	1.06235524
64	MP0001529_abnormal_vocalization	1.05704211
65	MP0002095_abnormal_skin_pigmentation	1.05652171
66	MP0008775_abnormal_heart_ventricle	1.05416368
67	MP0002557_abnormal_social/conspecific_i	1.04539719
68	MP0005386_behavior/neurological_phenoty	1.03160292
69	MP0004924_abnormal_behavior	1.03160292
70	MP0005195_abnormal_posterior_eye	1.01370008
71	MP0005410_abnormal_fertilization	1.01098227
72	MP0002751_abnormal_autonomic_nervous	0.98319177
73	MP0010386_abnormal_urinary_bladder	0.97513279
74	MP0002234_abnormal_pharynx_morphology	0.97192363
75	MP0005379_endocrine/exocrine_gland_phen	0.96759600
76	MP0002067_abnormal_sensory_capabilities	0.96683745
77	MP0000230_abnormal_systemic_arterial	0.95175585
78	MP0003283_abnormal_digestive_organ	0.93816294
79	MP0004742_abnormal_vestibular_system	0.93494756
80	MP0005085_abnormal_gallbladder_physiolo	0.91935868
81	MP0001324_abnormal_eye_pigmentation	0.88074264
82	MP0002063_abnormal_learning/memory/cond	0.87021543
83	MP0008058_abnormal_DNA_repair	0.86150525
84	MP0004215_abnormal_myocardial_fiber	0.85545624
85	MP0003137_abnormal_impulse_conducting	0.84647088
86	MP0000026_abnormal_inner_ear	0.84359780
87	MP0002752_abnormal_somatic_nervous	0.83749375
88	MP0003635_abnormal_synaptic_transmissio	0.81980308
89	MP0001502_abnormal_circadian_rhythm	0.80311560
90	MP0000647_abnormal_sebaceous_gland	0.79217955
91	MP0003698_abnormal_male_reproductive	0.78448470
92	MP0005332_abnormal_amino_acid	0.78350011
93	MP0002693_abnormal_pancreas_physiology	0.77814239
94	MP0002229_neurodegeneration	0.77289028
95	MP0003121_genomic_imprinting	0.76131676
96	MP0001963_abnormal_hearing_physiology	0.75826902
97	MP0001293_anophthalmia	0.74060148
98	MP0008995_early_reproductive_senescence	0.73478482
99	MP0005671_abnormal_response_to	0.73025799
100	MP0001929_abnormal_gametogenesis	0.72938244

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.68685241
2	Pancreatic fibrosis (HP:0100732)	4.12306647
3	Molar tooth sign on MRI (HP:0002419)	4.00224159
4	Abnormality of midbrain morphology (HP:0002418)	4.00224159
5	True hermaphroditism (HP:0010459)	3.95599441
6	Nephronophthisis (HP:0000090)	3.74466063
7	Congenital stationary night blindness (HP:0007642)	3.61361471
8	Type II lissencephaly (HP:0007260)	3.42238057
9	Abnormality of the renal cortex (HP:0011035)	3.26804729
10	Abnormality of the renal medulla (HP:0100957)	3.19268116
11	Abolished electroretinogram (ERG) (HP:0000550)	3.06843577
12	Medial flaring of the eyebrow (HP:0010747)	3.04038793
13	Attenuation of retinal blood vessels (HP:0007843)	2.92480294
14	Progressive inability to walk (HP:0002505)	2.89847370
15	Congenital, generalized hypertrichosis (HP:0004540)	2.81942500
16	Cystic liver disease (HP:0006706)	2.78635770
17	Chronic hepatic failure (HP:0100626)	2.76992335
18	Tubular atrophy (HP:0000092)	2.72362221
19	Inability to walk (HP:0002540)	2.66466051
20	Pendular nystagmus (HP:0012043)	2.61070262
21	Hyperventilation (HP:0002883)	2.60161128
22	Sclerocornea (HP:0000647)	2.59049589
23	Abnormal drinking behavior (HP:0030082)	2.57666412
24	Polydipsia (HP:0001959)	2.57666412
25	Abnormality of alanine metabolism (HP:0010916)	2.52644636
26	Hyperalaninemia (HP:0003348)	2.52644636
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52644636
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.51377340
29	Cerebellar dysplasia (HP:0007033)	2.45911957
30	Increased corneal curvature (HP:0100692)	2.43113586
31	Keratoconus (HP:0000563)	2.43113586
32	Renal cortical cysts (HP:0000803)	2.39722336
33	Male pseudohermaphroditism (HP:0000037)	2.39565000
34	Lissencephaly (HP:0001339)	2.36860967
35	Decreased central vision (HP:0007663)	2.33967512
36	Large for gestational age (HP:0001520)	2.32577430
37	Gaze-evoked nystagmus (HP:0000640)	2.29861458
38	Gait imbalance (HP:0002141)	2.28267527
39	Congenital hepatic fibrosis (HP:0002612)	2.24848414
40	Furrowed tongue (HP:0000221)	2.23970817
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23469029
42	Congenital primary aphakia (HP:0007707)	2.21813639
43	Bile duct proliferation (HP:0001408)	2.20912655
44	Abnormal biliary tract physiology (HP:0012439)	2.20912655
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19486520
46	Retinal dysplasia (HP:0007973)	2.18604023
47	Mitochondrial inheritance (HP:0001427)	2.16882213
48	Acute necrotizing encephalopathy (HP:0006965)	2.15116961
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12072614
50	Increased CSF lactate (HP:0002490)	2.10530395
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09640559
52	3-Methylglutaconic aciduria (HP:0003535)	2.08069925
53	Anencephaly (HP:0002323)	2.07526628
54	Nephrogenic diabetes insipidus (HP:0009806)	2.07259758
55	Polyuria (HP:0000103)	2.06427324
56	Patellar aplasia (HP:0006443)	2.03902516
57	Methylmalonic acidemia (HP:0002912)	2.03774754
58	Postaxial foot polydactyly (HP:0001830)	2.00992859
59	Progressive cerebellar ataxia (HP:0002073)	2.00431760
60	Aplasia/Hypoplasia of the patella (HP:0006498)	1.96907963
61	Absent/shortened dynein arms (HP:0200106)	1.96538299
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96538299
63	Febrile seizures (HP:0002373)	1.96519228
64	Stomach cancer (HP:0012126)	1.96470926
65	Broad-based gait (HP:0002136)	1.93088065
66	Decreased circulating renin level (HP:0003351)	1.92567050
67	Progressive macrocephaly (HP:0004481)	1.90646958
68	Absent thumb (HP:0009777)	1.90295808
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89887039
70	Optic disc pallor (HP:0000543)	1.89367288
71	Methylmalonic aciduria (HP:0012120)	1.89097766
72	Acute encephalopathy (HP:0006846)	1.88262777
73	Pachygyria (HP:0001302)	1.87386900
74	Hypothermia (HP:0002045)	1.87058788
75	Bony spicule pigmentary retinopathy (HP:0007737)	1.86946545
76	Genital tract atresia (HP:0001827)	1.86525432
77	Concave nail (HP:0001598)	1.85511171
78	Optic nerve hypoplasia (HP:0000609)	1.85258897
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85029612
80	Severe muscular hypotonia (HP:0006829)	1.81877873
81	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80318520
82	Hepatocellular necrosis (HP:0001404)	1.79906475
83	Abnormal mitochondria in muscle tissue (HP:0008316)	1.79298521
84	Abnormality of the pons (HP:0007361)	1.78225414
85	Vaginal atresia (HP:0000148)	1.78186667
86	Postaxial hand polydactyly (HP:0001162)	1.76332164
87	Chorioretinal atrophy (HP:0000533)	1.75543706
88	Hyperglycinuria (HP:0003108)	1.75065419
89	Hemiparesis (HP:0001269)	1.74828067
90	Genetic anticipation (HP:0003743)	1.74733972
91	Fair hair (HP:0002286)	1.74093869
92	Ketosis (HP:0001946)	1.71942578
93	Lipid accumulation in hepatocytes (HP:0006561)	1.71390056
94	Abnormality of the ileum (HP:0001549)	1.71169052
95	Hepatic necrosis (HP:0002605)	1.70961558
96	Bilateral microphthalmos (HP:0007633)	1.70562448
97	Congenital sensorineural hearing impairment (HP:0008527)	1.68923482
98	Abnormality of the labia minora (HP:0012880)	1.68912517
99	Hypoplasia of the pons (HP:0012110)	1.68694087
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.67658200

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.39471245
2	BMPR1B	3.35073346
3	ADRBK2	3.19057181
4	ZAK	2.97111393
5	MAP4K2	2.64922959
6	WNK3	2.55878341
7	INSRR	2.46890052
8	GRK1	2.46263179
9	TLK1	2.45795424
10	ACVR1B	2.44398089
11	NUAK1	2.42394706
12	TAOK3	2.30664962
13	WNK4	2.20405240
14	TXK	2.14216231
15	PINK1	1.94178084
16	MAPK13	1.72016993
17	OXSR1	1.63589257
18	MAP3K4	1.63146191
19	CASK	1.62883353
20	PNCK	1.40709853
21	MUSK	1.34734262
22	STK39	1.30291825
23	MKNK2	1.26359246
24	ADRBK1	1.18576263
25	DAPK2	1.16255174
26	MARK1	1.13950184
27	TGFBR1	1.10812362
28	PAK3	1.03686424
29	VRK1	1.03604466
30	TNIK	1.02087133
31	DYRK2	1.01812505
32	TRIM28	0.97356175
33	PRKCG	0.96352945
34	PRKCE	0.93035798
35	CAMKK2	0.91386679
36	BRSK2	0.90883764
37	PLK2	0.89097062
38	BCKDK	0.87581203
39	MAP2K7	0.84818159
40	MAPKAPK3	0.84074517
41	PHKG1	0.82164024
42	PHKG2	0.82164024
43	WEE1	0.79520155
44	KIT	0.77831081
45	STK16	0.77479352
46	TIE1	0.75019457
47	IRAK1	0.72438275
48	IKBKB	0.72163926
49	MAPK15	0.71967595
50	FLT3	0.70781235
51	NME1	0.70537787
52	VRK2	0.70059879
53	CSNK1G2	0.67990406
54	PRKCQ	0.67163055
55	PRKCI	0.66925045
56	TEC	0.66180989
57	MST4	0.63157815
58	MKNK1	0.62869231
59	MAPKAPK5	0.61930039
60	PLK3	0.61526375
61	ERBB3	0.60676224
62	MAP2K6	0.60309662
63	STK38L	0.60271325
64	CSNK1G1	0.60028623
65	EIF2AK3	0.59999518
66	NTRK3	0.59002006
67	RPS6KA5	0.58935931
68	PIK3CA	0.58153653
69	FGFR2	0.56544507
70	NEK2	0.55916019
71	STK3	0.54358904
72	NTRK2	0.52872269
73	PTK2B	0.51742750
74	GRK7	0.51496160
75	PKN1	0.51002904
76	PLK4	0.50831869
77	CSNK1G3	0.50137390
78	NLK	0.49140836
79	ITK	0.48223145
80	CHEK2	0.47859955
81	CHUK	0.46762651
82	PRKACA	0.44765356
83	CDK19	0.44038962
84	CDK8	0.41990654
85	CAMK2A	0.41597250
86	STK11	0.40969646
87	TAF1	0.40425521
88	CAMK1	0.39067938
89	CSNK1A1	0.38337945
90	CCNB1	0.38141684
91	CSNK1A1L	0.37725124
92	PRKCA	0.35330888
93	BCR	0.34888275
94	SYK	0.34471446
95	PLK1	0.34371980
96	IKBKE	0.34004549
97	ATR	0.32035111
98	CSNK1D	0.30503250
99	OBSCN	0.29445701
100	IGF1R	0.28478178

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.59771103
2	Phototransduction_Homo sapiens_hsa04744	2.52493223
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42518269
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.42401299
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38142071
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32346151
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31341223
8	Homologous recombination_Homo sapiens_hsa03440	2.29640867
9	Butanoate metabolism_Homo sapiens_hsa00650	2.20139714
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19711217
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13098933
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.04587680
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.99949675
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.95527551
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94631060
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91825767
17	Caffeine metabolism_Homo sapiens_hsa00232	1.90064968
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89955787
19	Protein export_Homo sapiens_hsa03060	1.87965964
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82989080
21	Basal transcription factors_Homo sapiens_hsa03022	1.82418219
22	Nicotine addiction_Homo sapiens_hsa05033	1.81534849
23	Parkinsons disease_Homo sapiens_hsa05012	1.73426480
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.68358724
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.62662379
26	RNA polymerase_Homo sapiens_hsa03020	1.61071543
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49035711
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44931075
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39975374
30	RNA degradation_Homo sapiens_hsa03018	1.39420196
31	Asthma_Homo sapiens_hsa05310	1.25135560
32	Taste transduction_Homo sapiens_hsa04742	1.24065807
33	Propanoate metabolism_Homo sapiens_hsa00640	1.21756326
34	Olfactory transduction_Homo sapiens_hsa04740	1.20975996
35	Peroxisome_Homo sapiens_hsa04146	1.19284119
36	Huntingtons disease_Homo sapiens_hsa05016	1.13564509
37	ABC transporters_Homo sapiens_hsa02010	1.11509921
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08378536
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07650404
40	Alzheimers disease_Homo sapiens_hsa05010	1.07599115
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06543836
42	Morphine addiction_Homo sapiens_hsa05032	1.06361613
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04661003
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03940795
45	One carbon pool by folate_Homo sapiens_hsa00670	1.00570414
46	Graft-versus-host disease_Homo sapiens_hsa05332	1.00223172
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.98306638
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97580126
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97327015
50	Retinol metabolism_Homo sapiens_hsa00830	0.94215326
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94192395
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.92060728
53	Serotonergic synapse_Homo sapiens_hsa04726	0.90606497
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.86658460
55	Regulation of autophagy_Homo sapiens_hsa04140	0.83085794
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81916856
57	Insulin secretion_Homo sapiens_hsa04911	0.81891371
58	Allograft rejection_Homo sapiens_hsa05330	0.80946163
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80763215
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80098448
61	Proteasome_Homo sapiens_hsa03050	0.79719253
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77824736
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75778593
64	Circadian entrainment_Homo sapiens_hsa04713	0.75628733
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75549273
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74792836
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74054564
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73983160
69	GABAergic synapse_Homo sapiens_hsa04727	0.71459590
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69935311
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.69294272
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.67986276
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67666912
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.67504926
75	Salivary secretion_Homo sapiens_hsa04970	0.66280171
76	Purine metabolism_Homo sapiens_hsa00230	0.64955591
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63823411
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.61193195
79	Histidine metabolism_Homo sapiens_hsa00340	0.59920219
80	Ribosome_Homo sapiens_hsa03010	0.58291142
81	Metabolic pathways_Homo sapiens_hsa01100	0.58068785
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.57938440
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57739271
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.56932547
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55392536
86	Fatty acid degradation_Homo sapiens_hsa00071	0.54777781
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54501561
88	Sulfur metabolism_Homo sapiens_hsa00920	0.51801380
89	Mineral absorption_Homo sapiens_hsa04978	0.43276185
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41784546
91	Circadian rhythm_Homo sapiens_hsa04710	0.38745809
92	Sulfur relay system_Homo sapiens_hsa04122	0.37831293
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.36899071
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.36497546
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36490380
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34088104
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34031196
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32836721
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.32267139
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31716358

ZNF665

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »