ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.67700848
2	gamma-aminobutyric acid transport (GO:0015812)	3.95133598
3	pyrimidine nucleobase catabolic process (GO:0006208)	3.70311900
4	response to pheromone (GO:0019236)	3.69610961
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.68165128
6	neural tube formation (GO:0001841)	3.43449207
7	presynaptic membrane assembly (GO:0097105)	3.34740135
8	behavioral response to ethanol (GO:0048149)	3.33664484
9	piRNA metabolic process (GO:0034587)	3.31288033
10	postsynaptic membrane organization (GO:0001941)	3.25996734
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24166998
12	protein K11-linked deubiquitination (GO:0035871)	3.23894322
13	L-fucose catabolic process (GO:0042355)	3.22765614
14	fucose catabolic process (GO:0019317)	3.22765614
15	L-fucose metabolic process (GO:0042354)	3.22765614
16	nucleobase catabolic process (GO:0046113)	3.21631840
17	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.18273381
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.18210774
19	detection of light stimulus involved in visual perception (GO:0050908)	3.18210774
20	indolalkylamine metabolic process (GO:0006586)	3.18013435
21	neuronal action potential propagation (GO:0019227)	3.17172183
22	neuronal action potential (GO:0019228)	3.16916393
23	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.12785952
24	kynurenine metabolic process (GO:0070189)	3.08817665
25	nonmotile primary cilium assembly (GO:0035058)	3.03336389
26	presynaptic membrane organization (GO:0097090)	3.03117550
27	retinal cone cell development (GO:0046549)	3.02991342
28	tryptophan catabolic process (GO:0006569)	3.00164597
29	indole-containing compound catabolic process (GO:0042436)	3.00164597
30	indolalkylamine catabolic process (GO:0046218)	3.00164597
31	neuron cell-cell adhesion (GO:0007158)	2.96253008
32	transmission of nerve impulse (GO:0019226)	2.96165395
33	proline transport (GO:0015824)	2.93011514
34	reflex (GO:0060004)	2.91872518
35	serotonin metabolic process (GO:0042428)	2.90830872
36	protein localization to cilium (GO:0061512)	2.89881082
37	glutamate receptor signaling pathway (GO:0007215)	2.89659411
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87937854
39	kidney morphogenesis (GO:0060993)	2.87131235
40	cellular ketone body metabolic process (GO:0046950)	2.85463104
41	startle response (GO:0001964)	2.85317962
42	synaptic transmission, glutamatergic (GO:0035249)	2.83438085
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.83371659
44	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.83219112
45	membrane depolarization during action potential (GO:0086010)	2.82209986
46	axoneme assembly (GO:0035082)	2.78882031
47	photoreceptor cell maintenance (GO:0045494)	2.77763951
48	indole-containing compound metabolic process (GO:0042430)	2.75916522
49	protein polyglutamylation (GO:0018095)	2.75266717
50	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.75041567
51	regulation of collateral sprouting (GO:0048670)	2.73967274
52	vocalization behavior (GO:0071625)	2.70976920
53	primary amino compound metabolic process (GO:1901160)	2.70597696
54	tryptophan metabolic process (GO:0006568)	2.68465279
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.67504800
56	protein localization to synapse (GO:0035418)	2.66952000
57	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.65980425
58	regulation of translation, ncRNA-mediated (GO:0045974)	2.65980425
59	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.65980425
60	neurotransmitter-gated ion channel clustering (GO:0072578)	2.65964193
61	DNA methylation involved in gamete generation (GO:0043046)	2.65157434
62	epithelial cilium movement (GO:0003351)	2.64840835
63	cilium morphogenesis (GO:0060271)	2.64728507
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.61846322
65	regulation of action potential (GO:0098900)	2.59498310
66	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.59221479
67	cornea development in camera-type eye (GO:0061303)	2.59150144
68	ketone body metabolic process (GO:1902224)	2.58431957
69	neuron-neuron synaptic transmission (GO:0007270)	2.56236476
70	regulation of cilium movement (GO:0003352)	2.53610290
71	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.52604723
72	action potential (GO:0001508)	2.52513201
73	cilium organization (GO:0044782)	2.52045342
74	sulfation (GO:0051923)	2.50304244
75	spinal cord motor neuron differentiation (GO:0021522)	2.47383079
76	cilium assembly (GO:0042384)	2.45553122
77	photoreceptor cell development (GO:0042461)	2.45430881
78	seminiferous tubule development (GO:0072520)	2.44037044
79	C4-dicarboxylate transport (GO:0015740)	2.43258012
80	inner ear receptor stereocilium organization (GO:0060122)	2.42135805
81	regulation of hippo signaling (GO:0035330)	2.41926578
82	platelet dense granule organization (GO:0060155)	2.40150124
83	adaptation of signaling pathway (GO:0023058)	2.39499129
84	cAMP catabolic process (GO:0006198)	2.38897016
85	auditory receptor cell stereocilium organization (GO:0060088)	2.38712666
86	limb bud formation (GO:0060174)	2.37122579
87	intraciliary transport (GO:0042073)	2.35600006
88	righting reflex (GO:0060013)	2.35423133
89	glycerophospholipid catabolic process (GO:0046475)	2.34782101
90	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.33719558
91	synaptic transmission, cholinergic (GO:0007271)	2.32912389
92	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.31158935
93	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.31058674
94	dendritic spine morphogenesis (GO:0060997)	2.30851734
95	positive regulation of action potential (GO:0045760)	2.30629263
96	embryonic epithelial tube formation (GO:0001838)	2.30261714
97	regulation of posttranscriptional gene silencing (GO:0060147)	2.30228276
98	regulation of gene silencing by miRNA (GO:0060964)	2.30228276
99	regulation of gene silencing by RNA (GO:0060966)	2.30228276
100	rhodopsin mediated signaling pathway (GO:0016056)	2.29565400

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.01632692
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.56776558
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.54979244
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16543634
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79139388
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77617532
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74416479
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59704823
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46036744
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.42029059
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.37236553
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35373189
13	FUS_26573619_Chip-Seq_HEK293_Human	2.25208359
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17519160
15	P300_19829295_ChIP-Seq_ESCs_Human	2.16995322
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06750878
17	EWS_26573619_Chip-Seq_HEK293_Human	2.05643390
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96364768
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95786847
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88917474
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81063316
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80616948
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79557723
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78708964
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73759578
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.73516307
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70186450
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67443524
29	STAT3_23295773_ChIP-Seq_U87_Human	1.65307325
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59914816
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.59730644
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56740907
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54737229
34	TCF4_23295773_ChIP-Seq_U87_Human	1.54304148
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.54114479
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54114479
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53102673
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53102673
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52363945
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51593612
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50192067
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50140961
43	AR_25329375_ChIP-Seq_VCAP_Human	1.49254371
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48624057
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48097442
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48014720
47	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46226344
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43434407
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41874601
50	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40763566
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.39025229
52	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38590859
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36896630
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.36775375
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36267897
56	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29782845
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28831906
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.27529237
59	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27282007
60	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26168658
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24406114
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.22112757
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21877047
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.21022686
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20259473
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20118433
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19150044
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18574436
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18503763
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17372601
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14331506
72	DROSHA_22980978_ChIP-Seq_HELA_Human	1.13755244
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13395425
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13395425
75	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13352540
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12975941
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11473281
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11354494
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10509366
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10389864
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09736557
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09564715
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06893082
84	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06587946
85	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06304842
86	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04854538
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04372501
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04030400
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01920697
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01155189
91	KDM2B_26808549_Chip-Seq_REH_Human	1.01108823
92	TP53_16413492_ChIP-PET_HCT116_Human	1.00395619
93	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00118037
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00006603
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00006603
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99979042
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99842592
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99492347
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98902249
100	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97502735

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.45112827
2	MP0000569_abnormal_digit_pigmentation	3.32490288
3	MP0003787_abnormal_imprinting	3.07668938
4	MP0003880_abnormal_central_pattern	2.95929693
5	MP0001968_abnormal_touch/_nociception	2.63640215
6	MP0009745_abnormal_behavioral_response	2.43379102
7	MP0002102_abnormal_ear_morphology	2.31816438
8	MP0005551_abnormal_eye_electrophysiolog	2.29308023
9	MP0006292_abnormal_olfactory_placode	2.25631445
10	MP0002736_abnormal_nociception_after	2.21086420
11	MP0009046_muscle_twitch	2.20305815
12	MP0005646_abnormal_pituitary_gland	2.14123384
13	MP0002272_abnormal_nervous_system	2.10713407
14	MP0001486_abnormal_startle_reflex	2.10614448
15	MP0006276_abnormal_autonomic_nervous	2.08419951
16	MP0003195_calcinosis	2.01997378
17	MP0001501_abnormal_sleep_pattern	2.00546331
18	MP0003635_abnormal_synaptic_transmissio	1.97298172
19	MP0002064_seizures	1.90481283
20	MP0004043_abnormal_pH_regulation	1.88014749
21	MP0004859_abnormal_synaptic_plasticity	1.85842597
22	MP0002735_abnormal_chemical_nociception	1.82677120
23	MP0002572_abnormal_emotion/affect_behav	1.80524622
24	MP0001984_abnormal_olfaction	1.79892717
25	MP0006072_abnormal_retinal_apoptosis	1.73364361
26	MP0002638_abnormal_pupillary_reflex	1.71267085
27	MP0002837_dystrophic_cardiac_calcinosis	1.69164148
28	MP0002063_abnormal_learning/memory/cond	1.67728254
29	MP0005253_abnormal_eye_physiology	1.64940214
30	MP0002938_white_spotting	1.64824207
31	MP0004885_abnormal_endolymph	1.64717737
32	MP0008872_abnormal_physiological_respon	1.59844063
33	MP0004142_abnormal_muscle_tone	1.58724497
34	MP0000631_abnormal_neuroendocrine_gland	1.58676963
35	MP0005645_abnormal_hypothalamus_physiol	1.58527956
36	MP0003136_yellow_coat_color	1.56403724
37	MP0003121_genomic_imprinting	1.54116907
38	MP0000778_abnormal_nervous_system	1.53343717
39	MP0002734_abnormal_mechanical_nocicepti	1.52436650
40	MP0002557_abnormal_social/conspecific_i	1.51019385
41	MP0001970_abnormal_pain_threshold	1.50477025
42	MP0002733_abnormal_thermal_nociception	1.48174288
43	MP0001986_abnormal_taste_sensitivity	1.43185196
44	MP0002067_abnormal_sensory_capabilities	1.42131176
45	MP0001485_abnormal_pinna_reflex	1.39691664
46	MP0003122_maternal_imprinting	1.37082144
47	MP0005386_behavior/neurological_phenoty	1.34688773
48	MP0004924_abnormal_behavior	1.34688773
49	MP0004147_increased_porphyrin_level	1.34387060
50	MP0005174_abnormal_tail_pigmentation	1.25023096
51	MP0004270_analgesia	1.24755456
52	MP0002184_abnormal_innervation	1.23804231
53	MP0005423_abnormal_somatic_nervous	1.22475687
54	MP0000427_abnormal_hair_cycle	1.22289565
55	MP0005084_abnormal_gallbladder_morpholo	1.21793908
56	MP0004133_heterotaxia	1.21466418
57	MP0001529_abnormal_vocalization	1.20729036
58	MP0002876_abnormal_thyroid_physiology	1.17345270
59	MP0002653_abnormal_ependyma_morphology	1.17325586
60	MP0010386_abnormal_urinary_bladder	1.11947030
61	MP0004145_abnormal_muscle_electrophysio	1.10705254
62	MP0003646_muscle_fatigue	1.09733620
63	MP0000372_irregular_coat_pigmentation	1.08175284
64	MP0005171_absent_coat_pigmentation	1.05590063
65	MP0003011_delayed_dark_adaptation	1.02703802
66	MP0004742_abnormal_vestibular_system	1.02331997
67	MP0001502_abnormal_circadian_rhythm	1.02159854
68	MP0002234_abnormal_pharynx_morphology	0.99170518
69	MP0002752_abnormal_somatic_nervous	0.97746742
70	MP0000955_abnormal_spinal_cord	0.97093684
71	MP0002882_abnormal_neuron_morphology	0.96539592
72	MP0008058_abnormal_DNA_repair	0.95925486
73	MP0001188_hyperpigmentation	0.95248426
74	MP0004215_abnormal_myocardial_fiber	0.94827830
75	MP0001440_abnormal_grooming_behavior	0.93515753
76	MP0002909_abnormal_adrenal_gland	0.92553202
77	MP0002751_abnormal_autonomic_nervous	0.91999726
78	MP0005195_abnormal_posterior_eye	0.91659685
79	MP0002160_abnormal_reproductive_system	0.88062915
80	MP0003890_abnormal_embryonic-extraembry	0.87188023
81	MP0003698_abnormal_male_reproductive	0.86179673
82	MP0002229_neurodegeneration	0.85439501
83	MP0001963_abnormal_hearing_physiology	0.84767373
84	MP0003937_abnormal_limbs/digits/tail_de	0.83762124
85	MP0002928_abnormal_bile_duct	0.82909436
86	MP0001905_abnormal_dopamine_level	0.82327465
87	MP0005410_abnormal_fertilization	0.79349005
88	MP0004085_abnormal_heartbeat	0.77834879
89	MP0003633_abnormal_nervous_system	0.77433094
90	MP0000230_abnormal_systemic_arterial	0.77327674
91	MP0003718_maternal_effect	0.77218424
92	MP0005389_reproductive_system_phenotype	0.77149438
93	MP0003119_abnormal_digestive_system	0.77063296
94	MP0008789_abnormal_olfactory_epithelium	0.77019752
95	MP0000383_abnormal_hair_follicle	0.75624855
96	MP0002066_abnormal_motor_capabilities/c	0.75362463
97	MP0002152_abnormal_brain_morphology	0.73825051
98	MP0000026_abnormal_inner_ear	0.72639194
99	MP0001293_anophthalmia	0.72180074
100	MP0003137_abnormal_impulse_conducting	0.69950644

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08880880
2	Hyperventilation (HP:0002883)	4.00906330
3	Nephronophthisis (HP:0000090)	3.71942346
4	Pancreatic fibrosis (HP:0100732)	3.68996296
5	Abnormality of midbrain morphology (HP:0002418)	3.65032944
6	Molar tooth sign on MRI (HP:0002419)	3.65032944
7	True hermaphroditism (HP:0010459)	3.62115402
8	Focal motor seizures (HP:0011153)	3.59575637
9	Congenital stationary night blindness (HP:0007642)	3.38792610
10	Febrile seizures (HP:0002373)	3.30374909
11	Medial flaring of the eyebrow (HP:0010747)	3.27764406
12	Abnormality of the renal medulla (HP:0100957)	3.26451441
13	Focal seizures (HP:0007359)	3.17954120
14	Gaze-evoked nystagmus (HP:0000640)	3.08691334
15	Progressive cerebellar ataxia (HP:0002073)	2.98683197
16	Type II lissencephaly (HP:0007260)	2.95090357
17	Protruding tongue (HP:0010808)	2.89100379
18	Broad-based gait (HP:0002136)	2.85961777
19	Abnormality of the renal cortex (HP:0011035)	2.84444703
20	Gait imbalance (HP:0002141)	2.78220723
21	Attenuation of retinal blood vessels (HP:0007843)	2.65874125
22	Absent speech (HP:0001344)	2.63437364
23	Cystic liver disease (HP:0006706)	2.63288287
24	Genetic anticipation (HP:0003743)	2.61158944
25	Dialeptic seizures (HP:0011146)	2.61098596
26	Abolished electroretinogram (ERG) (HP:0000550)	2.57717604
27	Congenital primary aphakia (HP:0007707)	2.57529384
28	Stomach cancer (HP:0012126)	2.57169686
29	Atonic seizures (HP:0010819)	2.55072846
30	Abnormality of the labia minora (HP:0012880)	2.55015176
31	Chronic hepatic failure (HP:0100626)	2.51460858
32	Tubular atrophy (HP:0000092)	2.50279555
33	Polydipsia (HP:0001959)	2.49959725
34	Abnormal drinking behavior (HP:0030082)	2.49959725
35	Inability to walk (HP:0002540)	2.48022205
36	Hemiparesis (HP:0001269)	2.40157352
37	Epileptic encephalopathy (HP:0200134)	2.40068979
38	Nephrogenic diabetes insipidus (HP:0009806)	2.36994948
39	Genital tract atresia (HP:0001827)	2.36782917
40	Progressive inability to walk (HP:0002505)	2.31557373
41	Vaginal atresia (HP:0000148)	2.30135290
42	Intestinal atresia (HP:0011100)	2.28694953
43	Colon cancer (HP:0003003)	2.27547899
44	Drooling (HP:0002307)	2.23733467
45	Tubulointerstitial nephritis (HP:0001970)	2.23181126
46	Decreased central vision (HP:0007663)	2.21285401
47	Increased corneal curvature (HP:0100692)	2.20153654
48	Keratoconus (HP:0000563)	2.20153654
49	Pendular nystagmus (HP:0012043)	2.18364877
50	Lissencephaly (HP:0001339)	2.13624026
51	Hypothermia (HP:0002045)	2.10705354
52	Congenital hepatic fibrosis (HP:0002612)	2.08851023
53	Methylmalonic acidemia (HP:0002912)	2.08590369
54	Sclerocornea (HP:0000647)	2.08468880
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.07114231
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05599549
57	Absent/shortened dynein arms (HP:0200106)	2.05599549
58	Absence seizures (HP:0002121)	2.04176499
59	Bile duct proliferation (HP:0001408)	2.03889591
60	Abnormal biliary tract physiology (HP:0012439)	2.03889591
61	Cerebellar dysplasia (HP:0007033)	2.03776178
62	Limb dystonia (HP:0002451)	2.03693375
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02363538
64	Renal cortical cysts (HP:0000803)	2.01181052
65	Widely spaced teeth (HP:0000687)	2.00748001
66	Bony spicule pigmentary retinopathy (HP:0007737)	2.00195059
67	Optic nerve hypoplasia (HP:0000609)	1.97822992
68	Excessive salivation (HP:0003781)	1.96673330
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93572142
70	Fair hair (HP:0002286)	1.93072496
71	Polyuria (HP:0000103)	1.93034590
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92756489
73	Abnormality of alanine metabolism (HP:0010916)	1.92756489
74	Hyperalaninemia (HP:0003348)	1.92756489
75	Poor coordination (HP:0002370)	1.90984089
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86285938
77	Methylmalonic aciduria (HP:0012120)	1.85306278
78	Anencephaly (HP:0002323)	1.84504842
79	Postaxial hand polydactyly (HP:0001162)	1.82907362
80	Congenital sensorineural hearing impairment (HP:0008527)	1.82480038
81	Postaxial foot polydactyly (HP:0001830)	1.82132989
82	Tubulointerstitial abnormality (HP:0001969)	1.80756955
83	Clumsiness (HP:0002312)	1.80417161
84	Narrow forehead (HP:0000341)	1.80019241
85	Male pseudohermaphroditism (HP:0000037)	1.79143501
86	Specific learning disability (HP:0001328)	1.75220877
87	Generalized tonic-clonic seizures (HP:0002069)	1.72359108
88	Small hand (HP:0200055)	1.72284703
89	Pachygyria (HP:0001302)	1.71449838
90	Hypoplasia of the pons (HP:0012110)	1.71026301
91	Abnormality of the pons (HP:0007361)	1.70533156
92	Furrowed tongue (HP:0000221)	1.70162226
93	Retinal dysplasia (HP:0007973)	1.69553159
94	Astigmatism (HP:0000483)	1.68822238
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67943037
96	Volvulus (HP:0002580)	1.67448093
97	Retinitis pigmentosa (HP:0000510)	1.66570834
98	Epileptiform EEG discharges (HP:0011182)	1.65795274
99	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.64942422
100	Large for gestational age (HP:0001520)	1.64664966

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.38703054
2	WNK3	3.29987891
3	MAP4K2	2.80506189
4	CASK	2.74586962
5	ADRBK2	2.37852622
6	BMPR1B	2.26584048
7	MARK1	2.25210275
8	PINK1	2.23882199
9	NUAK1	2.17852119
10	MAP3K4	2.09754920
11	MAPK13	2.09449997
12	ZAK	2.05841566
13	GRK1	1.99302812
14	ACVR1B	1.81206848
15	INSRR	1.77805544
16	NTRK3	1.77134930
17	MKNK2	1.71724725
18	TNIK	1.70390912
19	DAPK2	1.68595538
20	EPHA4	1.56873405
21	WNK4	1.53809267
22	TAOK3	1.47466189
23	OXSR1	1.41560226
24	PLK2	1.33911542
25	MAP2K7	1.31920575
26	PNCK	1.31326452
27	DYRK2	1.27314805
28	STK39	1.26603189
29	PAK3	1.25521600
30	FGFR2	1.23760682
31	CAMKK2	1.20404749
32	NTRK2	1.17007736
33	MKNK1	1.09299794
34	PRKCG	1.09265639
35	AKT3	1.07105961
36	TRIM28	1.06547727
37	PRKCE	1.02233381
38	BCKDK	0.93256053
39	CSNK1G1	0.92599503
40	CSNK1G2	0.90841481
41	ADRBK1	0.89494717
42	STK38L	0.84980291
43	BCR	0.84455983
44	DYRK1A	0.84432067
45	BRSK2	0.81853786
46	PHKG1	0.81812955
47	PHKG2	0.81812955
48	MAP2K4	0.79555981
49	SGK2	0.77257271
50	TXK	0.72386050
51	TLK1	0.70935093
52	CAMK2A	0.70722081
53	TGFBR1	0.70652070
54	CSNK1G3	0.69951964
55	CSNK1A1L	0.68985522
56	STK16	0.68223689
57	TEC	0.66707626
58	PAK6	0.65745733
59	CAMK1	0.62671866
60	PIK3CA	0.61662552
61	SGK494	0.61165266
62	SGK223	0.61165266
63	PKN1	0.60069983
64	VRK1	0.58606780
65	PLK3	0.57716284
66	CDK19	0.57431523
67	PTK2B	0.56786023
68	MAPKAPK5	0.55560736
69	PLK4	0.55219595
70	TNK2	0.54365976
71	MINK1	0.54041533
72	NLK	0.53999578
73	STK11	0.52828737
74	FLT3	0.52335009
75	MUSK	0.50409840
76	TIE1	0.48472318
77	EIF2AK3	0.48391850
78	PRKACA	0.46829959
79	MAPK15	0.46113554
80	CAMKK1	0.44715659
81	OBSCN	0.44147588
82	CDK3	0.43661796
83	CDK5	0.43135814
84	CCNB1	0.42910430
85	CSNK1D	0.42289005
86	KIT	0.41596757
87	ERBB3	0.41171241
88	CSNK1A1	0.40405526
89	PRKG1	0.39922374
90	CAMK1G	0.39863527
91	SGK1	0.39318836
92	PRKCQ	0.39139182
93	PRKCZ	0.39009633
94	SIK2	0.38339174
95	PRKAA1	0.37681726
96	TSSK6	0.37510540
97	PRKCH	0.37296892
98	GRK5	0.36822810
99	RPS6KA5	0.36142663
100	PIK3CG	0.35286681

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.50572690
2	Phototransduction_Homo sapiens_hsa04744	2.97109828
3	Butanoate metabolism_Homo sapiens_hsa00650	2.49998260
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30472278
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.26683219
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.22937450
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05746965
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.02963848
9	Circadian entrainment_Homo sapiens_hsa04713	2.02405063
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99577131
11	Morphine addiction_Homo sapiens_hsa05032	1.99374759
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98564257
13	Taste transduction_Homo sapiens_hsa04742	1.97865280
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82953144
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.81053009
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.78920905
17	GABAergic synapse_Homo sapiens_hsa04727	1.77116289
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.74029097
19	Olfactory transduction_Homo sapiens_hsa04740	1.71955732
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71150437
21	Propanoate metabolism_Homo sapiens_hsa00640	1.67227969
22	Insulin secretion_Homo sapiens_hsa04911	1.62907266
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.62486336
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62431217
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.60987809
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53790534
27	Basal transcription factors_Homo sapiens_hsa03022	1.51504044
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48697015
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.47480732
30	Serotonergic synapse_Homo sapiens_hsa04726	1.43359345
31	Protein export_Homo sapiens_hsa03060	1.36827421
32	Salivary secretion_Homo sapiens_hsa04970	1.34720869
33	RNA polymerase_Homo sapiens_hsa03020	1.31789810
34	Amphetamine addiction_Homo sapiens_hsa05031	1.27669392
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.27096940
36	Homologous recombination_Homo sapiens_hsa03440	1.24444459
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.21516842
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21106708
39	Long-term depression_Homo sapiens_hsa04730	1.16659606
40	Cocaine addiction_Homo sapiens_hsa05030	1.16387484
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13690281
42	RNA degradation_Homo sapiens_hsa03018	1.08288695
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00380978
44	ABC transporters_Homo sapiens_hsa02010	0.99374209
45	Regulation of autophagy_Homo sapiens_hsa04140	0.96419525
46	Cholinergic synapse_Homo sapiens_hsa04725	0.95795701
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95286086
48	Oxidative phosphorylation_Homo sapiens_hsa00190	0.92794490
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91771859
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89131803
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.87583825
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.86896991
53	Peroxisome_Homo sapiens_hsa04146	0.84758435
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83060910
55	Retinol metabolism_Homo sapiens_hsa00830	0.82245152
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82058401
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81995732
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80664561
59	Caffeine metabolism_Homo sapiens_hsa00232	0.80301057
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80024454
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79597115
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78097957
63	Parkinsons disease_Homo sapiens_hsa05012	0.76916893
64	Renin secretion_Homo sapiens_hsa04924	0.75940357
65	Gastric acid secretion_Homo sapiens_hsa04971	0.75826975
66	Circadian rhythm_Homo sapiens_hsa04710	0.75742489
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.75401236
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73834110
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73210832
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72455878
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.71253990
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70926578
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64728426
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64142852
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63316972
76	Purine metabolism_Homo sapiens_hsa00230	0.61069325
77	Histidine metabolism_Homo sapiens_hsa00340	0.59733831
78	One carbon pool by folate_Homo sapiens_hsa00670	0.59278802
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57598833
80	Huntingtons disease_Homo sapiens_hsa05016	0.55863238
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55191222
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51757132
83	Lysine degradation_Homo sapiens_hsa00310	0.49895452
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.46784417
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45213784
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.44480298
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.44130026
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44056066
89	Alzheimers disease_Homo sapiens_hsa05010	0.43602033
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43592734
91	Fatty acid degradation_Homo sapiens_hsa00071	0.43553392
92	Metabolic pathways_Homo sapiens_hsa01100	0.42266567
93	Axon guidance_Homo sapiens_hsa04360	0.41719270
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41483740
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41042150
96	Pancreatic secretion_Homo sapiens_hsa04972	0.40097738
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33466426
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32891821
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29905872
100	Mineral absorption_Homo sapiens_hsa04978	0.28251182

ZNF667

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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