ZNF669

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.70127164
2cullin deneddylation (GO:0010388)3.99421492
3pyrimidine nucleobase catabolic process (GO:0006208)3.88156655
4DNA double-strand break processing (GO:0000729)3.80241323
5fucose catabolic process (GO:0019317)3.69889215
6L-fucose metabolic process (GO:0042354)3.69889215
7L-fucose catabolic process (GO:0042355)3.69889215
8neural tube formation (GO:0001841)3.68518029
9protein-cofactor linkage (GO:0018065)3.66641581
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65251131
11platelet dense granule organization (GO:0060155)3.59310334
12DNA deamination (GO:0045006)3.57630868
13protein deneddylation (GO:0000338)3.54912211
14maturation of 5.8S rRNA (GO:0000460)3.33254973
15epithelial cilium movement (GO:0003351)3.32829195
16response to pheromone (GO:0019236)3.32129446
17kidney morphogenesis (GO:0060993)3.30408911
18replication fork processing (GO:0031297)3.26078198
19protein import into peroxisome matrix (GO:0016558)3.21793781
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21260879
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21260879
22nucleobase catabolic process (GO:0046113)3.21024311
23nonmotile primary cilium assembly (GO:0035058)3.19624087
24negative regulation of telomere maintenance (GO:0032205)3.18647360
25regulation of telomere maintenance (GO:0032204)3.13486762
26somite rostral/caudal axis specification (GO:0032525)3.10398933
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09087888
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.09087888
29regulation of translation, ncRNA-mediated (GO:0045974)3.09087888
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.00264860
31synapsis (GO:0007129)2.94949460
32head development (GO:0060322)2.90532609
33detection of light stimulus involved in visual perception (GO:0050908)2.87731729
34detection of light stimulus involved in sensory perception (GO:0050962)2.87731729
35protein complex biogenesis (GO:0070271)2.87555678
36intracellular protein transmembrane import (GO:0044743)2.84459467
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83468008
38somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82801778
39somatic hypermutation of immunoglobulin genes (GO:0016446)2.82801778
40establishment of protein localization to mitochondrial membrane (GO:0090151)2.81833591
41ubiquinone metabolic process (GO:0006743)2.80526002
42DNA integration (GO:0015074)2.79789329
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79312327
44protein prenylation (GO:0018342)2.79246751
45prenylation (GO:0097354)2.79246751
46positive regulation of gastrulation (GO:2000543)2.79019666
47histone H2A acetylation (GO:0043968)2.78953856
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78093159
49mitochondrial respiratory chain complex I assembly (GO:0032981)2.78093159
50NADH dehydrogenase complex assembly (GO:0010257)2.78093159
51protein K6-linked ubiquitination (GO:0085020)2.78055565
52mitochondrial respiratory chain complex assembly (GO:0033108)2.77606746
53ubiquinone biosynthetic process (GO:0006744)2.76233578
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73994052
55mitochondrial RNA metabolic process (GO:0000959)2.73060408
56recombinational repair (GO:0000725)2.72773584
57endoderm formation (GO:0001706)2.72648889
58cilium morphogenesis (GO:0060271)2.72036869
59protein polyglutamylation (GO:0018095)2.71530376
60negative regulation of DNA-dependent DNA replication (GO:2000104)2.71091216
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70911015
62anterograde synaptic vesicle transport (GO:0048490)2.70897093
63intraciliary transport (GO:0042073)2.70885391
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70591867
65organelle disassembly (GO:1903008)2.70272397
66cellular ketone body metabolic process (GO:0046950)2.70158788
67nucleotide transmembrane transport (GO:1901679)2.69897453
68double-strand break repair via homologous recombination (GO:0000724)2.67759820
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66278893
70regulation of helicase activity (GO:0051095)2.65997707
71protein targeting to peroxisome (GO:0006625)2.65841835
72establishment of protein localization to peroxisome (GO:0072663)2.65841835
73protein localization to peroxisome (GO:0072662)2.65841835
74respiratory chain complex IV assembly (GO:0008535)2.62580094
75limb bud formation (GO:0060174)2.60913842
76tRNA processing (GO:0008033)2.60188235
77cornea development in camera-type eye (GO:0061303)2.58961043
78regulation of mitotic spindle checkpoint (GO:1903504)2.58535544
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58535544
80regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.58368011
81indolalkylamine metabolic process (GO:0006586)2.57229965
82axoneme assembly (GO:0035082)2.55016599
83centriole replication (GO:0007099)2.54920591
84protein localization to cilium (GO:0061512)2.53844592
85water-soluble vitamin biosynthetic process (GO:0042364)2.53317633
86pyrimidine dimer repair (GO:0006290)2.50765503
87energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50516880
88ATP synthesis coupled proton transport (GO:0015986)2.50516880
89ketone body metabolic process (GO:1902224)2.50011604
90cilium movement (GO:0003341)2.49878443
91piRNA metabolic process (GO:0034587)2.48761270
92regulation of centriole replication (GO:0046599)2.47695418
93rRNA catabolic process (GO:0016075)2.47473660
94cilium organization (GO:0044782)2.45342146
95retinal cone cell development (GO:0046549)2.40479354
96DNA demethylation (GO:0080111)2.39749698
97negative regulation of mast cell activation (GO:0033004)2.39702609
98cytochrome complex assembly (GO:0017004)2.38991047
99cilium assembly (GO:0042384)2.38511345
100indolalkylamine catabolic process (GO:0046218)2.37440638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.27581249
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.25150799
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86854873
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82281741
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73433555
6VDR_22108803_ChIP-Seq_LS180_Human2.72638375
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.71773644
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62114157
9EWS_26573619_Chip-Seq_HEK293_Human2.52911955
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.48872163
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46943746
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45921394
13GBX2_23144817_ChIP-Seq_PC3_Human2.45614344
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36914607
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33630260
16EZH2_22144423_ChIP-Seq_EOC_Human2.33594740
17TAF15_26573619_Chip-Seq_HEK293_Human2.29255884
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26978933
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.24879345
20FUS_26573619_Chip-Seq_HEK293_Human2.20667028
21IGF1R_20145208_ChIP-Seq_DFB_Human2.18794854
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99432327
23P300_19829295_ChIP-Seq_ESCs_Human1.98146606
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94979631
25ELK1_19687146_ChIP-ChIP_HELA_Human1.89238296
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.78486796
27IRF1_19129219_ChIP-ChIP_H3396_Human1.77097706
28ER_23166858_ChIP-Seq_MCF-7_Human1.75958393
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69483582
30VDR_23849224_ChIP-Seq_CD4+_Human1.69321440
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68587204
32MYC_18940864_ChIP-ChIP_HL60_Human1.66431621
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62094024
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60434786
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55614542
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55585990
37TP53_22573176_ChIP-Seq_HFKS_Human1.52533012
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50481186
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47037855
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46676940
41RNF2_27304074_Chip-Seq_NSC_Mouse1.44631549
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43905567
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43905567
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.43754686
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42525967
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40967930
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40888039
48* TP63_19390658_ChIP-ChIP_HaCaT_Human1.39072857
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37357247
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36980745
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36917718
52CBP_20019798_ChIP-Seq_JUKART_Human1.36638576
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36638576
54BCAT_22108803_ChIP-Seq_LS180_Human1.34058259
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33221367
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31838990
57SOX2_19829295_ChIP-Seq_ESCs_Human1.29628635
58NANOG_19829295_ChIP-Seq_ESCs_Human1.29628635
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26675485
60SMAD4_21799915_ChIP-Seq_A2780_Human1.25267601
61FOXP3_21729870_ChIP-Seq_TREG_Human1.25257530
62AR_25329375_ChIP-Seq_VCAP_Human1.24652324
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24139762
64STAT3_23295773_ChIP-Seq_U87_Human1.23242872
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20995473
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20666819
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.20300765
68TCF4_23295773_ChIP-Seq_U87_Human1.20186890
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19088653
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18395126
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18096448
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16214696
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.16023781
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.15702193
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15702193
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.10294877
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.09830395
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09403047
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.09192080
80RUNX2_22187159_ChIP-Seq_PCA_Human1.08116863
81TCF4_22108803_ChIP-Seq_LS180_Human1.07993483
82REST_21632747_ChIP-Seq_MESCs_Mouse1.06957274
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06725181
84NCOR_22424771_ChIP-Seq_293T_Human1.02883131
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02717735
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.02080905
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.00558417
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99820688
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99616985
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99178136
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98768580
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98313789
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.96345075
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.95463160
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94448574
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92773272
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92357630
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91983433
99HOXB7_26014856_ChIP-Seq_BT474_Human0.91963937
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91716361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.58566250
2MP0003787_abnormal_imprinting3.11569634
3MP0002102_abnormal_ear_morphology3.08141075
4MP0003880_abnormal_central_pattern2.72557453
5MP0003890_abnormal_embryonic-extraembry2.47573303
6MP0008058_abnormal_DNA_repair2.31583713
7MP0009046_muscle_twitch2.18855851
8MP0003121_genomic_imprinting2.14653974
9MP0003195_calcinosis2.11570925
10MP0001529_abnormal_vocalization2.09235052
11MP0002638_abnormal_pupillary_reflex2.07497260
12MP0006276_abnormal_autonomic_nervous2.06138511
13MP0002736_abnormal_nociception_after2.05882026
14MP0001968_abnormal_touch/_nociception1.96184730
15MP0006072_abnormal_retinal_apoptosis1.93639468
16MP0000569_abnormal_digit_pigmentation1.91903140
17MP0004133_heterotaxia1.89024808
18MP0006292_abnormal_olfactory_placode1.85747067
19MP0003283_abnormal_digestive_organ1.85351542
20MP0002938_white_spotting1.83991539
21MP0004147_increased_porphyrin_level1.83266354
22MP0005551_abnormal_eye_electrophysiolog1.82057540
23MP0005253_abnormal_eye_physiology1.78729505
24MP0005645_abnormal_hypothalamus_physiol1.78625634
25MP0002822_catalepsy1.74381701
26MP0001986_abnormal_taste_sensitivity1.68333499
27MP0003122_maternal_imprinting1.63271064
28MP0002876_abnormal_thyroid_physiology1.62756192
29MP0000372_irregular_coat_pigmentation1.59151928
30MP0005084_abnormal_gallbladder_morpholo1.58715961
31MP0005386_behavior/neurological_phenoty1.57981150
32MP0004924_abnormal_behavior1.57981150
33MP0008995_early_reproductive_senescence1.55175861
34MP0002751_abnormal_autonomic_nervous1.54723177
35MP0002557_abnormal_social/conspecific_i1.51048265
36MP0008872_abnormal_physiological_respon1.48810315
37MP0003718_maternal_effect1.48201831
38MP0002272_abnormal_nervous_system1.45837014
39MP0001984_abnormal_olfaction1.45349642
40MP0002837_dystrophic_cardiac_calcinosis1.42071369
41MP0004142_abnormal_muscle_tone1.41799782
42MP0002735_abnormal_chemical_nociception1.39686823
43MP0002254_reproductive_system_inflammat1.36452444
44MP0009745_abnormal_behavioral_response1.35981764
45MP0000778_abnormal_nervous_system1.34413054
46MP0000631_abnormal_neuroendocrine_gland1.33647538
47MP0008057_abnormal_DNA_replication1.33564586
48MP0010094_abnormal_chromosome_stability1.25860059
49MP0003136_yellow_coat_color1.25769693
50MP0001486_abnormal_startle_reflex1.20157981
51MP0002160_abnormal_reproductive_system1.20053010
52MP0003567_abnormal_fetal_cardiomyocyte1.19625507
53MP0003646_muscle_fatigue1.19601701
54MP0001188_hyperpigmentation1.18735355
55MP0005423_abnormal_somatic_nervous1.18684946
56MP0003693_abnormal_embryo_hatching1.15332717
57MP0004885_abnormal_endolymph1.14912611
58MP0002067_abnormal_sensory_capabilities1.13410425
59MP0001293_anophthalmia1.11720349
60MP0002653_abnormal_ependyma_morphology1.10725362
61MP0002163_abnormal_gland_morphology1.10219958
62MP0002572_abnormal_emotion/affect_behav1.10209884
63MP0004043_abnormal_pH_regulation1.09234607
64MP0003119_abnormal_digestive_system1.09070158
65MP0005389_reproductive_system_phenotype1.07262169
66MP0004742_abnormal_vestibular_system1.03957638
67MP0000427_abnormal_hair_cycle1.01640101
68MP0001485_abnormal_pinna_reflex1.01216839
69MP0000647_abnormal_sebaceous_gland1.00877870
70MP0001929_abnormal_gametogenesis1.00787676
71MP0002928_abnormal_bile_duct0.99873418
72MP0005195_abnormal_posterior_eye0.98468124
73MP0003786_premature_aging0.96078581
74MP0005075_abnormal_melanosome_morpholog0.95424066
75MP0002184_abnormal_innervation0.95038555
76MP0000516_abnormal_urinary_system0.94759927
77MP0005367_renal/urinary_system_phenotyp0.94759927
78MP0002234_abnormal_pharynx_morphology0.93984258
79MP0002752_abnormal_somatic_nervous0.93429724
80MP0002210_abnormal_sex_determination0.92671560
81MP0001970_abnormal_pain_threshold0.92288649
82MP0000538_abnormal_urinary_bladder0.91927585
83MP0005391_vision/eye_phenotype0.91583552
84MP0005646_abnormal_pituitary_gland0.91549400
85MP0005174_abnormal_tail_pigmentation0.91137691
86MP0001324_abnormal_eye_pigmentation0.90107732
87MP0002063_abnormal_learning/memory/cond0.88850073
88MP0001919_abnormal_reproductive_system0.88544330
89MP0003698_abnormal_male_reproductive0.88458793
90MP0003011_delayed_dark_adaptation0.87830765
91MP0008875_abnormal_xenobiotic_pharmacok0.87430253
92MP0000653_abnormal_sex_gland0.86515152
93MP0002095_abnormal_skin_pigmentation0.85704922
94MP0001119_abnormal_female_reproductive0.85450653
95MP0003635_abnormal_synaptic_transmissio0.85364267
96MP0005187_abnormal_penis_morphology0.83265456
97MP0003943_abnormal_hepatobiliary_system0.82791734
98MP0005379_endocrine/exocrine_gland_phen0.81814859
99MP0000955_abnormal_spinal_cord0.81634311
100MP0005167_abnormal_blood-brain_barrier0.79973773

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.78863192
2Abnormality of midbrain morphology (HP:0002418)3.59868228
3Molar tooth sign on MRI (HP:0002419)3.59868228
4Pancreatic fibrosis (HP:0100732)3.56726958
5True hermaphroditism (HP:0010459)3.49925707
6Congenital stationary night blindness (HP:0007642)3.02231086
7Abnormality of the renal cortex (HP:0011035)3.02077769
8Pendular nystagmus (HP:0012043)2.95896026
9Birth length less than 3rd percentile (HP:0003561)2.92034012
10Type II lissencephaly (HP:0007260)2.88900405
11Nephronophthisis (HP:0000090)2.85999114
12Medial flaring of the eyebrow (HP:0010747)2.85529946
13Renal cortical cysts (HP:0000803)2.79515466
14Colon cancer (HP:0003003)2.63399809
15Abnormality of the labia minora (HP:0012880)2.60856760
16Chronic hepatic failure (HP:0100626)2.55450089
17Abnormality of the renal medulla (HP:0100957)2.54222564
18Gait imbalance (HP:0002141)2.47853233
19Hyperventilation (HP:0002883)2.42833733
20Congenital primary aphakia (HP:0007707)2.39184711
21Abnormal pancreas size (HP:0012094)2.38758706
22Intestinal atresia (HP:0011100)2.38306108
23Abnormal rod and cone electroretinograms (HP:0008323)2.37017122
24Cerebellar dysplasia (HP:0007033)2.34730187
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32288474
26Methylmalonic acidemia (HP:0002912)2.31074387
27Lissencephaly (HP:0001339)2.31047367
28Attenuation of retinal blood vessels (HP:0007843)2.30868073
29Tubular atrophy (HP:0000092)2.28254539
30Nephrogenic diabetes insipidus (HP:0009806)2.22773394
31Genetic anticipation (HP:0003743)2.22641225
32Cystic liver disease (HP:0006706)2.20373931
33Progressive inability to walk (HP:0002505)2.20175314
34Abnormal drinking behavior (HP:0030082)2.18986108
35Polydipsia (HP:0001959)2.18986108
36Genital tract atresia (HP:0001827)2.18523586
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.18414589
38Anencephaly (HP:0002323)2.18125722
39Inability to walk (HP:0002540)2.16151839
40Abolished electroretinogram (ERG) (HP:0000550)2.15946314
41Abnormal biliary tract physiology (HP:0012439)2.15145135
42Bile duct proliferation (HP:0001408)2.15145135
43Vaginal atresia (HP:0000148)2.11945467
44Sclerocornea (HP:0000647)2.09891844
45Decreased central vision (HP:0007663)2.08455375
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.05433863
47Pachygyria (HP:0001302)2.03073338
48Patellar aplasia (HP:0006443)2.02112940
49Abnormality of the pons (HP:0007361)2.02030771
50Abnormality of the ileum (HP:0001549)2.01959940
51Meckel diverticulum (HP:0002245)2.01683280
52Ependymoma (HP:0002888)2.01453262
53Asplenia (HP:0001746)1.97924735
54Broad-based gait (HP:0002136)1.93693115
55Progressive cerebellar ataxia (HP:0002073)1.92524116
56Increased CSF lactate (HP:0002490)1.91485300
57Hypothermia (HP:0002045)1.89400114
58Male pseudohermaphroditism (HP:0000037)1.88139473
59Shawl scrotum (HP:0000049)1.86973208
60Hypoplasia of the pons (HP:0012110)1.86051155
61Aplasia/Hypoplasia of the patella (HP:0006498)1.85611381
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.84501579
63Methylmalonic aciduria (HP:0012120)1.83889779
64Polyuria (HP:0000103)1.83749904
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.83639170
66Scrotal hypoplasia (HP:0000046)1.82969057
67Dandy-Walker malformation (HP:0001305)1.81212657
68Mitochondrial inheritance (HP:0001427)1.80109778
69Retinal dysplasia (HP:0007973)1.79090143
70Disproportionate short-trunk short stature (HP:0003521)1.78806282
71Hemiparesis (HP:0001269)1.78602879
72Optic nerve hypoplasia (HP:0000609)1.78161931
73Large for gestational age (HP:0001520)1.78101750
74Gaze-evoked nystagmus (HP:0000640)1.77476599
75Supernumerary spleens (HP:0009799)1.76995966
76Volvulus (HP:0002580)1.76578133
77Abnormality of chromosome stability (HP:0003220)1.76480949
78Dysdiadochokinesis (HP:0002075)1.75763169
79Multicystic kidney dysplasia (HP:0000003)1.74904600
80Limb dystonia (HP:0002451)1.74334865
81Female pseudohermaphroditism (HP:0010458)1.74303894
82Esotropia (HP:0000565)1.74268434
83Severe muscular hypotonia (HP:0006829)1.72784496
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72769258
85Lipid accumulation in hepatocytes (HP:0006561)1.72678134
86Brushfield spots (HP:0001088)1.72344089
87Narrow forehead (HP:0000341)1.72250233
88Optic disc pallor (HP:0000543)1.71908665
89Protruding tongue (HP:0010808)1.71311722
90Congenital hepatic fibrosis (HP:0002612)1.70690642
91Tubulointerstitial nephritis (HP:0001970)1.70658897
92Polyphagia (HP:0002591)1.70420464
93Increased hepatocellular lipid droplets (HP:0006565)1.70342023
94Acute necrotizing encephalopathy (HP:0006965)1.70282238
95Postaxial hand polydactyly (HP:0001162)1.70205054
96Small hand (HP:0200055)1.69020225
97Stomach cancer (HP:0012126)1.67710685
98Sloping forehead (HP:0000340)1.67309746
99Abnormality of macular pigmentation (HP:0008002)1.67041220
100Postaxial foot polydactyly (HP:0001830)1.65747086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.23275403
2NUAK13.12471050
3ADRBK22.96523184
4WNK32.74505176
5BMPR1B2.63197137
6MAP3K42.39478183
7CASK2.30453861
8TSSK62.26993170
9WNK42.26526007
10ZAK2.19316008
11MAP4K22.17481770
12MKNK22.16952175
13ACVR1B2.07811055
14GRK12.03012739
15TRIM282.01101722
16TNIK1.83020693
17SRPK11.74790545
18MAP2K71.74377902
19VRK11.71389513
20MAPK131.71129272
21DYRK31.58997224
22PASK1.58338167
23MKNK11.57271274
24MARK11.52757500
25PINK11.50666525
26WEE11.45192033
27VRK21.42225497
28TIE11.41731112
29DYRK21.36103475
30OXSR11.34651087
31DAPK21.33429598
32PAK31.28201129
33BRSK21.25591663
34TLK11.22441720
35PLK31.21965047
36STK391.21655728
37BUB11.21073163
38BCR1.16026712
39PLK41.13326305
40CSNK1G21.10124206
41TGFBR11.08233519
42AKT31.07495636
43CSNK1G11.07167827
44ERBB31.06864117
45NME11.06196472
46INSRR1.03114619
47MST41.02295236
48PNCK1.01129830
49CSNK1G31.01074191
50CSNK1A1L0.97506252
51PRKCG0.85477792
52TXK0.84880900
53PRKCE0.81947273
54EIF2AK30.80084341
55BRD40.76183193
56MAPK150.76043988
57PLK10.73580858
58STK38L0.73515923
59PKN10.71312059
60NEK20.69370937
61TAF10.68269775
62ADRBK10.68164360
63PLK20.63281981
64ATR0.62292202
65CDC70.60657694
66PRKCH0.60321182
67STK30.57527246
68TEC0.56086892
69TAOK30.54699286
70STK160.53771509
71MAP2K40.53555452
72TTK0.53214821
73DYRK1A0.51490119
74PBK0.50800209
75SIK30.49661717
76MAP2K60.49581216
77RPS6KA50.48888066
78CHEK20.48184980
79ATM0.47255900
80PRKCQ0.44826258
81FGFR20.42887832
82SGK20.42475876
83RPS6KA40.41806309
84MINK10.39652336
85CAMK2A0.37292014
86EPHA40.36874166
87CSNK1A10.34944825
88BCKDK0.34606668
89CDK30.33959576
90PRKAA10.32620889
91MARK30.31756502
92PRKACA0.31574639
93PHKG20.31133274
94PHKG10.31133274
95FER0.31068080
96NEK10.30711091
97PRKCI0.30046619
98EIF2AK20.29322424
99CHEK10.29150723
100NTRK20.28864845

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06135905
2Protein export_Homo sapiens_hsa030602.96489169
3Fanconi anemia pathway_Homo sapiens_hsa034602.55650188
4Oxidative phosphorylation_Homo sapiens_hsa001902.47491283
5Basal transcription factors_Homo sapiens_hsa030222.38381144
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37021865
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.35183315
8Phototransduction_Homo sapiens_hsa047442.24729702
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22987712
10RNA polymerase_Homo sapiens_hsa030202.19783899
11Butanoate metabolism_Homo sapiens_hsa006502.16845328
12RNA degradation_Homo sapiens_hsa030182.14022928
13Homologous recombination_Homo sapiens_hsa034402.12826128
14Proteasome_Homo sapiens_hsa030502.11167242
15Parkinsons disease_Homo sapiens_hsa050122.04656328
16Nicotine addiction_Homo sapiens_hsa050331.89416899
17Propanoate metabolism_Homo sapiens_hsa006401.85220865
18Selenocompound metabolism_Homo sapiens_hsa004501.78207821
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77458711
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75909551
21Non-homologous end-joining_Homo sapiens_hsa034501.75248657
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73682823
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72565228
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70051919
25Steroid biosynthesis_Homo sapiens_hsa001001.53996144
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53824461
27Linoleic acid metabolism_Homo sapiens_hsa005911.48520985
28Regulation of autophagy_Homo sapiens_hsa041401.47910231
29Taste transduction_Homo sapiens_hsa047421.38986932
30Mismatch repair_Homo sapiens_hsa034301.38963109
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37984547
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34327763
33RNA transport_Homo sapiens_hsa030131.32837839
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32335144
35Huntingtons disease_Homo sapiens_hsa050161.28948803
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24790345
37Nitrogen metabolism_Homo sapiens_hsa009101.23993763
38Peroxisome_Homo sapiens_hsa041461.18894284
39Tryptophan metabolism_Homo sapiens_hsa003801.17585572
40Base excision repair_Homo sapiens_hsa034101.13237305
41Caffeine metabolism_Homo sapiens_hsa002321.10206597
42Spliceosome_Homo sapiens_hsa030401.05129391
43Alzheimers disease_Homo sapiens_hsa050101.02825052
44One carbon pool by folate_Homo sapiens_hsa006700.96286291
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96003844
46Ether lipid metabolism_Homo sapiens_hsa005650.93599889
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92687938
48Collecting duct acid secretion_Homo sapiens_hsa049660.92498941
49GABAergic synapse_Homo sapiens_hsa047270.89890296
50Ribosome_Homo sapiens_hsa030100.89844774
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88953471
52Olfactory transduction_Homo sapiens_hsa047400.88189433
53Purine metabolism_Homo sapiens_hsa002300.87253468
54Fatty acid elongation_Homo sapiens_hsa000620.83179791
55Pyrimidine metabolism_Homo sapiens_hsa002400.77739776
56Morphine addiction_Homo sapiens_hsa050320.77473154
57Cardiac muscle contraction_Homo sapiens_hsa042600.75929229
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72842924
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70059163
60Nucleotide excision repair_Homo sapiens_hsa034200.68031716
61Glutamatergic synapse_Homo sapiens_hsa047240.66992345
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.65286115
63p53 signaling pathway_Homo sapiens_hsa041150.65208655
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64911739
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64863525
66ABC transporters_Homo sapiens_hsa020100.64819537
67Serotonergic synapse_Homo sapiens_hsa047260.64767808
68Type I diabetes mellitus_Homo sapiens_hsa049400.64320084
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62728485
70Hedgehog signaling pathway_Homo sapiens_hsa043400.61983756
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.60641603
72Dopaminergic synapse_Homo sapiens_hsa047280.59640687
73mRNA surveillance pathway_Homo sapiens_hsa030150.58771244
74Cell cycle_Homo sapiens_hsa041100.58421286
75Long-term depression_Homo sapiens_hsa047300.56071124
76Metabolic pathways_Homo sapiens_hsa011000.56052422
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.54442931
78Retinol metabolism_Homo sapiens_hsa008300.53696265
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.53302651
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52877948
81Asthma_Homo sapiens_hsa053100.52817325
82Sulfur metabolism_Homo sapiens_hsa009200.51750448
83DNA replication_Homo sapiens_hsa030300.48974006
84Circadian entrainment_Homo sapiens_hsa047130.43662650
85Alcoholism_Homo sapiens_hsa050340.42522313
86Insulin secretion_Homo sapiens_hsa049110.41486734
87Circadian rhythm_Homo sapiens_hsa047100.39957096
88Chemical carcinogenesis_Homo sapiens_hsa052040.39026441
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38881518
90Basal cell carcinoma_Homo sapiens_hsa052170.38093538
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37736999
92Oocyte meiosis_Homo sapiens_hsa041140.37714990
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37639798
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37419747
95Primary immunodeficiency_Homo sapiens_hsa053400.35658016
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34857551
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30127145
98beta-Alanine metabolism_Homo sapiens_hsa004100.29340854
99Axon guidance_Homo sapiens_hsa043600.28908652
100Fat digestion and absorption_Homo sapiens_hsa049750.27622493

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