ZNF670

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.88148755
2chromatin remodeling at centromere (GO:0031055)4.57803369
3CENP-A containing nucleosome assembly (GO:0034080)4.49449864
4mitotic metaphase plate congression (GO:0007080)4.15344707
5proteasome assembly (GO:0043248)4.08228178
6regulation of mitotic spindle checkpoint (GO:1903504)4.07929924
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.07929924
8DNA replication checkpoint (GO:0000076)3.97341589
9histone exchange (GO:0043486)3.93135109
10metaphase plate congression (GO:0051310)3.86079596
11ribosome assembly (GO:0042255)3.82990903
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.82101120
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82101120
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.79836897
15regulation of centriole replication (GO:0046599)3.76820426
16DNA replication-independent nucleosome organization (GO:0034724)3.72562725
17DNA replication-independent nucleosome assembly (GO:0006336)3.72562725
18regulation of helicase activity (GO:0051095)3.70870845
19negative regulation of DNA recombination (GO:0045910)3.68219483
20DNA replication-dependent nucleosome assembly (GO:0006335)3.65718652
21DNA replication-dependent nucleosome organization (GO:0034723)3.65718652
22establishment of integrated proviral latency (GO:0075713)3.60843662
23DNA strand elongation involved in DNA replication (GO:0006271)3.56317981
24spindle checkpoint (GO:0031577)3.47556768
25DNA catabolic process, exonucleolytic (GO:0000738)3.46804630
26protein localization to kinetochore (GO:0034501)3.42616318
27telomere maintenance via semi-conservative replication (GO:0032201)3.40597869
28mitotic spindle checkpoint (GO:0071174)3.38357492
29kinetochore organization (GO:0051383)3.37212904
30DNA strand elongation (GO:0022616)3.35483798
31cullin deneddylation (GO:0010388)3.32263977
32negative regulation of mitotic sister chromatid separation (GO:2000816)3.30930084
33negative regulation of sister chromatid segregation (GO:0033046)3.30930084
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30930084
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30930084
36negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30930084
37kinetochore assembly (GO:0051382)3.30166730
38double-strand break repair via nonhomologous end joining (GO:0006303)3.28461525
39non-recombinational repair (GO:0000726)3.28461525
40DNA ligation (GO:0006266)3.27783390
41IMP biosynthetic process (GO:0006188)3.27238947
42negative regulation of chromosome segregation (GO:0051985)3.24474958
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.22401238
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22401238
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.20592663
46nuclear pore complex assembly (GO:0051292)3.19163061
47purine nucleobase biosynthetic process (GO:0009113)3.17889958
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16773987
49mitotic sister chromatid segregation (GO:0000070)3.16546892
50nuclear pore organization (GO:0006999)3.16060301
51mitotic nuclear envelope disassembly (GO:0007077)3.15078751
52DNA integration (GO:0015074)3.13308211
53mitotic recombination (GO:0006312)3.13135436
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08663985
55replication fork processing (GO:0031297)3.08596466
56protein neddylation (GO:0045116)3.07247395
57histone mRNA metabolic process (GO:0008334)3.07150445
58regulation of mitotic sister chromatid separation (GO:0010965)3.06135646
59regulation of mitotic sister chromatid segregation (GO:0033047)3.06135646
60regulation of sister chromatid segregation (GO:0033045)3.06135646
61establishment of chromosome localization (GO:0051303)3.05690999
62sister chromatid segregation (GO:0000819)3.04489505
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04366856
64mitotic spindle assembly checkpoint (GO:0007094)3.04242398
65mitochondrial RNA metabolic process (GO:0000959)3.04031410
66postreplication repair (GO:0006301)3.03901562
67regulation of chromosome segregation (GO:0051983)3.03437781
68DNA damage response, detection of DNA damage (GO:0042769)3.02979711
69protein deneddylation (GO:0000338)3.02887454
70telomere maintenance via recombination (GO:0000722)3.02678206
71attachment of spindle microtubules to kinetochore (GO:0008608)3.01677428
72mitotic sister chromatid cohesion (GO:0007064)3.01103859
73spindle assembly checkpoint (GO:0071173)2.99502713
74protein localization to chromosome, centromeric region (GO:0071459)2.95102820
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.94455211
76IMP metabolic process (GO:0046040)2.92862500
77histone H2A acetylation (GO:0043968)2.91531836
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90921883
79membrane disassembly (GO:0030397)2.90242052
80nuclear envelope disassembly (GO:0051081)2.90242052
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90235762
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90235762
83isotype switching (GO:0045190)2.90235762
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88977423
85spliceosomal snRNP assembly (GO:0000387)2.84387718
86L-serine metabolic process (GO:0006563)2.83836765
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81634058
88protein K6-linked ubiquitination (GO:0085020)2.79703853
89regulation of centrosome cycle (GO:0046605)2.79352968
90establishment of viral latency (GO:0019043)2.79232051
91nucleobase biosynthetic process (GO:0046112)2.77596309
92recombinational repair (GO:0000725)2.75599077
93microtubule depolymerization (GO:0007019)2.74107821
94termination of RNA polymerase II transcription (GO:0006369)2.73812269
95double-strand break repair via homologous recombination (GO:0000724)2.73656406
96response to X-ray (GO:0010165)2.73332477
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73286072
98maturation of 5.8S rRNA (GO:0000460)2.72904214
99negative regulation of mitosis (GO:0045839)2.72703033
100mitotic G2/M transition checkpoint (GO:0044818)2.70870464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26183952
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26591663
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75773721
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.30097688
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17446121
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.95195876
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75964590
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75604352
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.60968903
10ELK1_19687146_ChIP-ChIP_HELA_Human2.58074529
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52924588
12ZNF274_21170338_ChIP-Seq_K562_Hela2.46077650
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45129051
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38237799
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34810389
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31769672
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.31644321
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27028174
19EWS_26573619_Chip-Seq_HEK293_Human2.21981889
20IGF1R_20145208_ChIP-Seq_DFB_Human2.19981061
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17813273
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08239943
23AR_21909140_ChIP-Seq_LNCAP_Human2.06622335
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.05461513
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03600758
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01195808
27VDR_23849224_ChIP-Seq_CD4+_Human1.98799234
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94106652
29FUS_26573619_Chip-Seq_HEK293_Human1.94020943
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87382749
31FOXP3_21729870_ChIP-Seq_TREG_Human1.79982009
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79799744
33TAF15_26573619_Chip-Seq_HEK293_Human1.74449897
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73651664
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68128226
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67741313
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63090646
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62834359
39MYC_18940864_ChIP-ChIP_HL60_Human1.60041317
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.58287210
41VDR_22108803_ChIP-Seq_LS180_Human1.56445503
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54640947
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54578269
44* DCP1A_22483619_ChIP-Seq_HELA_Human1.53288502
45P300_19829295_ChIP-Seq_ESCs_Human1.51078768
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49186122
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.49128929
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.45183096
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43752919
50* NOTCH1_21737748_ChIP-Seq_TLL_Human1.42657816
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41687383
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.40956507
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39915892
54GABP_19822575_ChIP-Seq_HepG2_Human1.38190020
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35043985
56IRF1_19129219_ChIP-ChIP_H3396_Human1.34204848
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32618407
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31661867
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.27872323
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27610704
61TTF2_22483619_ChIP-Seq_HELA_Human1.26643105
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24779041
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24163763
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24126232
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20173636
66GBX2_23144817_ChIP-Seq_PC3_Human1.15041755
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15007791
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14407929
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14069311
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10986833
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09952191
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07429833
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07305694
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06976099
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04118693
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03278352
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.02404300
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.01485523
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01302198
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01067327
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99405540
82XRN2_22483619_ChIP-Seq_HELA_Human0.98418504
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97787948
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97228305
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96977551
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96400395
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95943655
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95578910
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95339719
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94946630
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90876823
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90161732
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89543985
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89021506
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87959981
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87814349
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85900916
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85803440
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83660270
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82500191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.95556582
2MP0008057_abnormal_DNA_replication3.81874153
3MP0008058_abnormal_DNA_repair3.55255728
4MP0003693_abnormal_embryo_hatching3.43647195
5MP0004957_abnormal_blastocyst_morpholog3.25954465
6MP0008877_abnormal_DNA_methylation3.16524082
7MP0002102_abnormal_ear_morphology3.01731920
8MP0003111_abnormal_nucleus_morphology2.89126533
9MP0001529_abnormal_vocalization2.80877299
10MP0006292_abnormal_olfactory_placode2.52382681
11MP0003077_abnormal_cell_cycle2.52111812
12MP0001293_anophthalmia2.37641648
13MP0008932_abnormal_embryonic_tissue2.30520467
14MP0003718_maternal_effect2.10724882
15MP0008789_abnormal_olfactory_epithelium2.03921818
16MP0003890_abnormal_embryonic-extraembry1.97955940
17MP0008007_abnormal_cellular_replicative1.92254974
18MP0003941_abnormal_skin_development1.85305572
19MP0002234_abnormal_pharynx_morphology1.79638959
20MP0003121_genomic_imprinting1.75849440
21MP0003880_abnormal_central_pattern1.73079876
22MP0006072_abnormal_retinal_apoptosis1.69641348
23MP0003567_abnormal_fetal_cardiomyocyte1.69602083
24MP0005499_abnormal_olfactory_system1.69019605
25MP0005394_taste/olfaction_phenotype1.69019605
26MP0003787_abnormal_imprinting1.61975442
27MP0003119_abnormal_digestive_system1.60709409
28MP0003937_abnormal_limbs/digits/tail_de1.59988313
29MP0009697_abnormal_copulation1.58714035
30MP0002751_abnormal_autonomic_nervous1.50731399
31MP0002938_white_spotting1.47576971
32MP0002233_abnormal_nose_morphology1.46601493
33MP0000647_abnormal_sebaceous_gland1.45080714
34MP0003122_maternal_imprinting1.39159736
35MP0003786_premature_aging1.38533885
36MP0001730_embryonic_growth_arrest1.36156743
37MP0001984_abnormal_olfaction1.35321975
38MP0006035_abnormal_mitochondrial_morpho1.34271214
39MP0005253_abnormal_eye_physiology1.29971826
40MP0004133_heterotaxia1.27676945
41MP0002084_abnormal_developmental_patter1.24375814
42MP0001286_abnormal_eye_development1.22694477
43MP0003195_calcinosis1.22434728
44MP0002085_abnormal_embryonic_tissue1.21269712
45MP0001929_abnormal_gametogenesis1.19820408
46MP0001697_abnormal_embryo_size1.18816990
47MP0009672_abnormal_birth_weight1.17878163
48MP0002210_abnormal_sex_determination1.14997954
49MP0001672_abnormal_embryogenesis/_devel1.14904683
50MP0005380_embryogenesis_phenotype1.14904683
51MP0004197_abnormal_fetal_growth/weight/1.14239571
52MP0005367_renal/urinary_system_phenotyp1.11453816
53MP0000516_abnormal_urinary_system1.11453816
54MP0003221_abnormal_cardiomyocyte_apopto1.10781875
55MP0006054_spinal_hemorrhage1.09088632
56MP0000778_abnormal_nervous_system1.07332154
57MP0000383_abnormal_hair_follicle1.06965537
58MP0001177_atelectasis1.06405943
59MP0004147_increased_porphyrin_level1.06016837
60MP0000350_abnormal_cell_proliferation1.05686231
61MP0001188_hyperpigmentation1.05484852
62MP0000631_abnormal_neuroendocrine_gland1.05231106
63MP0000049_abnormal_middle_ear1.04196104
64MP0000653_abnormal_sex_gland1.04154781
65MP0001145_abnormal_male_reproductive1.03719941
66MP0010030_abnormal_orbit_morphology1.02574573
67MP0002697_abnormal_eye_size1.02315798
68MP0009703_decreased_birth_body1.02168675
69MP0005391_vision/eye_phenotype0.99628964
70MP0004215_abnormal_myocardial_fiber0.98949146
71MP0006276_abnormal_autonomic_nervous0.96865168
72MP0000372_irregular_coat_pigmentation0.95809905
73MP0005248_abnormal_Harderian_gland0.94994178
74MP0002736_abnormal_nociception_after0.94383715
75MP0002254_reproductive_system_inflammat0.93390037
76MP0005187_abnormal_penis_morphology0.92609374
77MP0002111_abnormal_tail_morphology0.92160001
78MP0003186_abnormal_redox_activity0.91817148
79MP0006036_abnormal_mitochondrial_physio0.91816377
80MP0003984_embryonic_growth_retardation0.90972241
81MP0002080_prenatal_lethality0.90091201
82MP0003755_abnormal_palate_morphology0.89994354
83MP0003861_abnormal_nervous_system0.89717085
84MP0003698_abnormal_male_reproductive0.89193186
85MP0002088_abnormal_embryonic_growth/wei0.88760906
86MP0005551_abnormal_eye_electrophysiolog0.88314597
87MP0001119_abnormal_female_reproductive0.87956816
88MP0010678_abnormal_skin_adnexa0.86800276
89MP0001299_abnormal_eye_distance/0.83687638
90MP0003137_abnormal_impulse_conducting0.82853480
91MP0010307_abnormal_tumor_latency0.80401914
92MP0008995_early_reproductive_senescence0.79239759
93MP0002092_abnormal_eye_morphology0.77117221
94MP0000566_synostosis0.77063561
95MP0002160_abnormal_reproductive_system0.73370452
96MP0002090_abnormal_vision0.72824544
97MP0001764_abnormal_homeostasis0.72623930
98MP0003315_abnormal_perineum_morphology0.72278888
99MP0000313_abnormal_cell_death0.72184008
100MP0000427_abnormal_hair_cycle0.71940024

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.26308508
2Colon cancer (HP:0003003)3.88779281
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70503446
4Chromsome breakage (HP:0040012)3.47239586
5Meckel diverticulum (HP:0002245)2.89786770
6Birth length less than 3rd percentile (HP:0003561)2.86286941
7Ependymoma (HP:0002888)2.82450358
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.81128490
9Hyperglycinemia (HP:0002154)2.79731576
10Abnormality of chromosome stability (HP:0003220)2.75316348
11Abnormality of the ileum (HP:0001549)2.75145284
12Abnormal lung lobation (HP:0002101)2.73968601
13Abnormality of serum amino acid levels (HP:0003112)2.65968837
14Volvulus (HP:0002580)2.64505391
15Medulloblastoma (HP:0002885)2.59309640
16Cortical dysplasia (HP:0002539)2.53027724
17Duodenal stenosis (HP:0100867)2.44397979
18Small intestinal stenosis (HP:0012848)2.44397979
19True hermaphroditism (HP:0010459)2.43136753
20Abnormality of the preputium (HP:0100587)2.41149581
21Increased serum pyruvate (HP:0003542)2.38791464
22Degeneration of anterior horn cells (HP:0002398)2.32723308
23Abnormality of the anterior horn cell (HP:0006802)2.32723308
24Nephroblastoma (Wilms tumor) (HP:0002667)2.31853561
25Agnosia (HP:0010524)2.31088271
26Glioma (HP:0009733)2.31051516
27Abnormality of the duodenum (HP:0002246)2.29322846
28Increased hepatocellular lipid droplets (HP:0006565)2.26394143
29Pancreatic cysts (HP:0001737)2.25821281
30Pancreatic fibrosis (HP:0100732)2.24372553
31Embryonal renal neoplasm (HP:0011794)2.21566124
32Abnormality of serine family amino acid metabolism (HP:0010894)2.20144030
33Abnormality of glycine metabolism (HP:0010895)2.20144030
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19951799
35Abnormality of alanine metabolism (HP:0010916)2.19951799
36Hyperalaninemia (HP:0003348)2.19951799
37Rhabdomyosarcoma (HP:0002859)2.18950917
38Abnormality of glycolysis (HP:0004366)2.17469817
39Supernumerary spleens (HP:0009799)2.17446848
40Acute encephalopathy (HP:0006846)2.16695422
41Sloping forehead (HP:0000340)2.15639376
42Pendular nystagmus (HP:0012043)2.15058429
43Hyperglycinuria (HP:0003108)2.10828998
44Lipid accumulation in hepatocytes (HP:0006561)2.10082118
45Postnatal microcephaly (HP:0005484)2.09855273
46Biliary tract neoplasm (HP:0100574)2.07911215
47Methylmalonic acidemia (HP:0002912)2.07893156
48Intestinal atresia (HP:0011100)2.07785578
49Molar tooth sign on MRI (HP:0002419)2.06111721
50Abnormality of midbrain morphology (HP:0002418)2.06111721
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05545211
52Ectopic kidney (HP:0000086)2.04668026
53Absent radius (HP:0003974)2.02206117
54Breast carcinoma (HP:0003002)2.00799028
55Genital tract atresia (HP:0001827)1.99727045
56Aplasia/Hypoplasia of the tongue (HP:0010295)1.99034663
57Aplasia involving forearm bones (HP:0009822)1.97543349
58Absent forearm bone (HP:0003953)1.97543349
59Bifid tongue (HP:0010297)1.95346145
60Astrocytoma (HP:0009592)1.94417093
61Abnormality of the astrocytes (HP:0100707)1.94417093
62Neoplasm of the colon (HP:0100273)1.94131789
63Increased CSF lactate (HP:0002490)1.93372200
64Preaxial hand polydactyly (HP:0001177)1.93238287
65Triphalangeal thumb (HP:0001199)1.93086149
66Acute necrotizing encephalopathy (HP:0006965)1.92889937
67Congenital primary aphakia (HP:0007707)1.91128190
68Gait imbalance (HP:0002141)1.90299275
69Chronic hepatic failure (HP:0100626)1.88735505
70Medial flaring of the eyebrow (HP:0010747)1.88692153
71Vaginal atresia (HP:0000148)1.88063823
72Abnormality of methionine metabolism (HP:0010901)1.85947755
73Nephronophthisis (HP:0000090)1.85311145
74Dandy-Walker malformation (HP:0001305)1.84307775
75Short tibia (HP:0005736)1.83723330
76Pancreatic islet-cell hyperplasia (HP:0004510)1.83685071
77Nephrogenic diabetes insipidus (HP:0009806)1.83465639
78Median cleft lip (HP:0000161)1.81747474
79Ovarian neoplasm (HP:0100615)1.81674263
80Septo-optic dysplasia (HP:0100842)1.81495974
81Horseshoe kidney (HP:0000085)1.80797322
82Atrophy/Degeneration involving motor neurons (HP:0007373)1.80508834
83Gonadotropin excess (HP:0000837)1.80077456
84Patellar aplasia (HP:0006443)1.80033760
85Neoplasm of the adrenal gland (HP:0100631)1.79963130
86Small hand (HP:0200055)1.79719051
87Increased serum lactate (HP:0002151)1.79293091
88Progressive inability to walk (HP:0002505)1.78367508
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.78287114
90Hypoplastic pelvis (HP:0008839)1.77925981
91Oligodactyly (hands) (HP:0001180)1.77446842
92Type I transferrin isoform profile (HP:0003642)1.76763824
93Renal hypoplasia (HP:0000089)1.75672514
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.73687186
95Abnormality of the carotid arteries (HP:0005344)1.71712018
96Multiple enchondromatosis (HP:0005701)1.71040957
97Bilateral microphthalmos (HP:0007633)1.70672064
98Postaxial foot polydactyly (HP:0001830)1.70195919
99Stenosis of the external auditory canal (HP:0000402)1.69601177
100Progressive macrocephaly (HP:0004481)1.69019349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.25616924
2TRIM283.11027455
3SRPK13.03401306
4BUB12.98286812
5MKNK12.85049855
6MKNK22.78718935
7EIF2AK32.74238739
8BRSK22.67330271
9TTK2.57956160
10ZAK2.54093236
11TSSK62.49620561
12CDC72.47242132
13TNIK2.28695963
14PBK2.21108644
15WEE12.17683146
16PLK32.15823316
17BCR2.11607116
18MST42.08356285
19NUAK12.02166968
20PLK41.99709682
21NEK11.90639795
22MAP3K41.85567150
23EIF2AK11.73197960
24CCNB11.61244141
25ERBB31.59110593
26PLK11.51837508
27ACVR1B1.48791360
28PLK21.40201294
29BRSK11.34529552
30MAP4K21.32681376
31CSNK1G11.29940643
32VRK11.27954216
33MAP2K71.27337005
34CSNK1G31.26280007
35BMPR1B1.25693150
36VRK21.24963964
37DYRK31.20768596
38EPHA41.17244692
39MAPK131.16176255
40TAF11.16129792
41CSNK1G21.15475751
42CSNK1A1L1.12903179
43PDK21.07955741
44STK161.07785279
45CASK1.06777698
46ATR1.03787715
47CHEK21.01786916
48RPS6KA41.00747071
49DYRK21.00046778
50SIK30.94237031
51EIF2AK20.93988567
52STK38L0.87372169
53TIE10.87358032
54FRK0.85474768
55STK390.74156998
56NEK90.73426573
57GRK10.71999784
58ATM0.71611498
59AURKB0.70772518
60STK30.65192681
61ERBB40.63312914
62CDK190.60753855
63CLK10.59847974
64MARK10.59128278
65OXSR10.55492645
66BRD40.52292071
67CHEK10.52238715
68TGFBR10.47152978
69EPHA30.46022431
70CDK60.45354150
71FGFR10.43824845
72CSNK2A10.43130911
73BCKDK0.42988297
74CDK30.42573278
75NME10.42382573
76NEK20.40207463
77CDK10.39451801
78PAK40.37640880
79PRKCE0.37512530
80PASK0.36893405
81PNCK0.35491069
82NEK60.34964695
83AURKA0.34821771
84LATS10.34293268
85ALK0.33856860
86CDK140.33754971
87CDK70.33382896
88CSNK1A10.32571719
89CDK180.32144484
90PRKCI0.31704757
91BRAF0.31350015
92CDK20.31086622
93PAK30.30777908
94FER0.30743961
95CSNK2A20.30487354
96CSNK1E0.30393521
97PRKCG0.29470459
98ADRBK20.29437122
99MINK10.28481713
100PRKDC0.28299021

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.68635955
2Proteasome_Homo sapiens_hsa030503.35103686
3Non-homologous end-joining_Homo sapiens_hsa034503.17054851
4DNA replication_Homo sapiens_hsa030303.10882066
5Protein export_Homo sapiens_hsa030602.92179295
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64857150
7Fanconi anemia pathway_Homo sapiens_hsa034602.55343370
8Homologous recombination_Homo sapiens_hsa034402.49179215
9RNA transport_Homo sapiens_hsa030132.44943232
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42038312
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36523874
12Basal transcription factors_Homo sapiens_hsa030222.32970553
13RNA polymerase_Homo sapiens_hsa030202.28066624
14Cell cycle_Homo sapiens_hsa041102.23935606
15Propanoate metabolism_Homo sapiens_hsa006402.18610072
16Spliceosome_Homo sapiens_hsa030402.16232721
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16069924
18Base excision repair_Homo sapiens_hsa034102.13779280
19Steroid biosynthesis_Homo sapiens_hsa001002.13430443
20Nucleotide excision repair_Homo sapiens_hsa034201.86242290
21RNA degradation_Homo sapiens_hsa030181.81613551
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.71295680
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66866058
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65310827
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59712247
26Pyruvate metabolism_Homo sapiens_hsa006201.51117036
27One carbon pool by folate_Homo sapiens_hsa006701.45191451
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44900324
29Fatty acid elongation_Homo sapiens_hsa000621.44128188
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42984634
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39469188
32Selenocompound metabolism_Homo sapiens_hsa004501.36145249
33mRNA surveillance pathway_Homo sapiens_hsa030151.33608993
34Pyrimidine metabolism_Homo sapiens_hsa002401.31533808
35p53 signaling pathway_Homo sapiens_hsa041151.30828934
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25617783
37Parkinsons disease_Homo sapiens_hsa050121.21765899
38Oxidative phosphorylation_Homo sapiens_hsa001901.13470207
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13469856
40Oocyte meiosis_Homo sapiens_hsa041141.12708209
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12489054
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12395488
43Purine metabolism_Homo sapiens_hsa002301.04987759
44Vitamin B6 metabolism_Homo sapiens_hsa007501.03190264
45Butanoate metabolism_Homo sapiens_hsa006501.01339630
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94329483
47Huntingtons disease_Homo sapiens_hsa050160.94095916
48Carbon metabolism_Homo sapiens_hsa012000.90482722
49Biosynthesis of amino acids_Homo sapiens_hsa012300.90006656
50Caffeine metabolism_Homo sapiens_hsa002320.86859606
51Glutathione metabolism_Homo sapiens_hsa004800.86487877
52Folate biosynthesis_Homo sapiens_hsa007900.85413683
53Fatty acid metabolism_Homo sapiens_hsa012120.79968807
54Phototransduction_Homo sapiens_hsa047440.74379465
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73976429
56Regulation of autophagy_Homo sapiens_hsa041400.70968161
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66772173
58beta-Alanine metabolism_Homo sapiens_hsa004100.64733651
59Peroxisome_Homo sapiens_hsa041460.62800884
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62109602
61Metabolic pathways_Homo sapiens_hsa011000.60519677
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58377024
63TGF-beta signaling pathway_Homo sapiens_hsa043500.57704630
64Basal cell carcinoma_Homo sapiens_hsa052170.57004066
65Hippo signaling pathway_Homo sapiens_hsa043900.55348979
66Fatty acid degradation_Homo sapiens_hsa000710.54826342
67Alzheimers disease_Homo sapiens_hsa050100.52220194
68Nicotine addiction_Homo sapiens_hsa050330.51858775
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51628872
70Arginine and proline metabolism_Homo sapiens_hsa003300.47937872
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44875460
72Tryptophan metabolism_Homo sapiens_hsa003800.44685923
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44237207
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43915680
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42963253
76N-Glycan biosynthesis_Homo sapiens_hsa005100.41169013
77Hedgehog signaling pathway_Homo sapiens_hsa043400.41104198
78Wnt signaling pathway_Homo sapiens_hsa043100.37964913
79Fat digestion and absorption_Homo sapiens_hsa049750.33485587
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.33483907
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33427585
82Ether lipid metabolism_Homo sapiens_hsa005650.31667405
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31586425
84Colorectal cancer_Homo sapiens_hsa052100.31530853
85Nitrogen metabolism_Homo sapiens_hsa009100.30587577
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.30446014
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28629505
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26331569
89Olfactory transduction_Homo sapiens_hsa047400.26001456
90Alcoholism_Homo sapiens_hsa050340.25924042
91Lysine degradation_Homo sapiens_hsa003100.25673166
92Retinol metabolism_Homo sapiens_hsa008300.22956204
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22417508
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22188225
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21764760
96Epstein-Barr virus infection_Homo sapiens_hsa051690.21684448
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19336874
98Vitamin digestion and absorption_Homo sapiens_hsa049770.19296944
99Chemical carcinogenesis_Homo sapiens_hsa052040.16392089
100Adherens junction_Homo sapiens_hsa045200.15162201

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