ZNF670-ZNF695

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 670 (ZNF670) and zinc finger protein 695 (ZNF695) genes on chromosome 1. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)4.99281182
2indole-containing compound catabolic process (GO:0042436)4.97558994
3indolalkylamine catabolic process (GO:0046218)4.97558994
4tryptophan catabolic process (GO:0006569)4.97558994
5kynurenine metabolic process (GO:0070189)4.80512603
6regulation of hippo signaling (GO:0035330)4.49904066
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.47462858
8behavioral response to nicotine (GO:0035095)4.39517481
9tryptophan metabolic process (GO:0006568)4.25598151
10signal peptide processing (GO:0006465)4.25435814
11cilium or flagellum-dependent cell motility (GO:0001539)4.08374143
12monoubiquitinated protein deubiquitination (GO:0035520)4.06052577
13detection of light stimulus involved in sensory perception (GO:0050962)3.99646062
14detection of light stimulus involved in visual perception (GO:0050908)3.99646062
15neural tube formation (GO:0001841)3.93114601
16photoreceptor cell maintenance (GO:0045494)3.81625293
17regulation of posttranscriptional gene silencing (GO:0060147)3.81400706
18regulation of gene silencing by miRNA (GO:0060964)3.81400706
19regulation of gene silencing by RNA (GO:0060966)3.81400706
20reflex (GO:0060004)3.65406004
21indole-containing compound metabolic process (GO:0042430)3.61017053
22protein K48-linked deubiquitination (GO:0071108)3.60752468
23positive regulation of developmental pigmentation (GO:0048087)3.50025739
24fucose catabolic process (GO:0019317)3.41653844
25L-fucose metabolic process (GO:0042354)3.41653844
26L-fucose catabolic process (GO:0042355)3.41653844
27tachykinin receptor signaling pathway (GO:0007217)3.34779092
28behavioral response to ethanol (GO:0048149)3.32570541
29regulation of pigment cell differentiation (GO:0050932)3.31731431
30amine catabolic process (GO:0009310)3.27715030
31cellular biogenic amine catabolic process (GO:0042402)3.27715030
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.22905177
33regulation of translation, ncRNA-mediated (GO:0045974)3.22905177
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22905177
35regulation of sarcomere organization (GO:0060297)3.21954277
36benzene-containing compound metabolic process (GO:0042537)3.20188217
37protein K11-linked deubiquitination (GO:0035871)3.19764793
38NAD biosynthetic process (GO:0009435)3.19364781
39cellular ketone body metabolic process (GO:0046950)3.17697043
40protein K63-linked deubiquitination (GO:0070536)3.16630822
41auditory receptor cell stereocilium organization (GO:0060088)3.16302398
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12701451
43retinal cone cell development (GO:0046549)3.11781057
44serotonin metabolic process (GO:0042428)3.10282582
45gamma-aminobutyric acid transport (GO:0015812)3.09948381
46UDP-N-acetylglucosamine metabolic process (GO:0006047)3.09869636
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09834447
48establishment of protein localization to Golgi (GO:0072600)3.08626052
49cellular response to sterol (GO:0036315)3.05566075
50sulfation (GO:0051923)3.02275550
51negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94745873
52DNA double-strand break processing (GO:0000729)2.94030562
53reciprocal meiotic recombination (GO:0007131)2.89935472
54reciprocal DNA recombination (GO:0035825)2.89935472
55protein prenylation (GO:0018342)2.89600665
56prenylation (GO:0097354)2.89600665
57axoneme assembly (GO:0035082)2.89193284
58piRNA metabolic process (GO:0034587)2.89058433
59primary amino compound metabolic process (GO:1901160)2.88800986
60thyroid hormone metabolic process (GO:0042403)2.86961373
61ketone body metabolic process (GO:1902224)2.86038997
62DNA methylation involved in gamete generation (GO:0043046)2.85899150
63double-strand break repair via homologous recombination (GO:0000724)2.85401058
64positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.85152836
65recombinational repair (GO:0000725)2.83117125
66detection of mechanical stimulus involved in sensory perception (GO:0050974)2.83044125
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81146640
68snRNA transcription (GO:0009301)2.80510969
69oxidative demethylation (GO:0070989)2.78711058
70neuronal action potential (GO:0019228)2.73325496
71negative regulation of calcium ion transport into cytosol (GO:0010523)2.72436746
72interkinetic nuclear migration (GO:0022027)2.71540840
73inner ear receptor stereocilium organization (GO:0060122)2.69731789
74flavonoid metabolic process (GO:0009812)2.68601734
75aromatic amino acid family catabolic process (GO:0009074)2.67003958
76negative regulation of systemic arterial blood pressure (GO:0003085)2.65191819
77cilium movement (GO:0003341)2.65135318
78cilium organization (GO:0044782)2.63977514
79transmission of nerve impulse (GO:0019226)2.63803815
80histone H3-K9 methylation (GO:0051567)2.61350374
81aromatic amino acid family metabolic process (GO:0009072)2.60824699
82cilium morphogenesis (GO:0060271)2.59973623
83sphingoid metabolic process (GO:0046519)2.59338748
84dopamine transport (GO:0015872)2.59086776
85membrane depolarization during action potential (GO:0086010)2.58845566
86kidney morphogenesis (GO:0060993)2.58620841
87proline transport (GO:0015824)2.58176269
88microtubule anchoring (GO:0034453)2.57774967
89righting reflex (GO:0060013)2.57292052
90cilium assembly (GO:0042384)2.57041253
91protein localization to cilium (GO:0061512)2.54808618
92regulation of establishment of cell polarity (GO:2000114)2.54714128
93negative regulation of mast cell activation (GO:0033004)2.54547022
94phasic smooth muscle contraction (GO:0014821)2.54131097
95protein polyglutamylation (GO:0018095)2.53748920
96DNA deamination (GO:0045006)2.53724418
97spinal cord motor neuron differentiation (GO:0021522)2.53192144
98drug catabolic process (GO:0042737)2.51847382
99response to nitrosative stress (GO:0051409)2.51751339
100peristalsis (GO:0030432)2.49908378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.36602444
2GBX2_23144817_ChIP-Seq_PC3_Human3.29916864
3ZNF274_21170338_ChIP-Seq_K562_Hela3.19937112
4IGF1R_20145208_ChIP-Seq_DFB_Human2.90286927
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73982211
6EZH2_22144423_ChIP-Seq_EOC_Human2.69808048
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66831887
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59189151
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51759584
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45544961
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36261735
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.32032184
13TAF15_26573619_Chip-Seq_HEK293_Human2.16620174
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14796320
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12347779
16P300_19829295_ChIP-Seq_ESCs_Human2.12060685
17FUS_26573619_Chip-Seq_HEK293_Human2.10521718
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00220755
19EWS_26573619_Chip-Seq_HEK293_Human1.99487657
20ER_23166858_ChIP-Seq_MCF-7_Human1.99337114
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.97530686
22STAT3_23295773_ChIP-Seq_U87_Human1.97102199
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89452809
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.88892725
25SMAD4_21799915_ChIP-Seq_A2780_Human1.84381197
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84006543
27TCF4_23295773_ChIP-Seq_U87_Human1.75140434
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74061435
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73797497
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73797497
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72875320
32BCAT_22108803_ChIP-Seq_LS180_Human1.66730263
33CBP_20019798_ChIP-Seq_JUKART_Human1.64676072
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64676072
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62750667
36AR_21572438_ChIP-Seq_LNCaP_Human1.59705443
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55747606
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55599669
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53265662
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.50040030
41AR_25329375_ChIP-Seq_VCAP_Human1.49191002
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47333080
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47197326
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44839006
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44681445
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42080614
47TCF4_22108803_ChIP-Seq_LS180_Human1.40490346
48DROSHA_22980978_ChIP-Seq_HELA_Human1.39596704
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37998828
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.37382018
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.36842430
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.34430845
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33322835
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32179634
55RUNX2_22187159_ChIP-Seq_PCA_Human1.31646120
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30287474
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.29952847
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28589400
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27396724
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26892884
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25512724
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25507394
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24532118
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.24478193
65TP53_22573176_ChIP-Seq_HFKS_Human1.23769472
66SOX2_19829295_ChIP-Seq_ESCs_Human1.21862111
67NANOG_19829295_ChIP-Seq_ESCs_Human1.21862111
68REST_21632747_ChIP-Seq_MESCs_Mouse1.21228307
69CDX2_22108803_ChIP-Seq_LS180_Human1.20237754
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.19945602
71TP53_16413492_ChIP-PET_HCT116_Human1.19475304
72IRF1_19129219_ChIP-ChIP_H3396_Human1.18543287
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18469967
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.17491080
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16029737
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15454560
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10709820
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.10566614
79RNF2_27304074_Chip-Seq_NSC_Mouse1.09889514
80KDM2B_26808549_Chip-Seq_REH_Human1.08167344
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.07501726
82AHR_22903824_ChIP-Seq_MCF-7_Human1.06703591
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.06474375
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06415897
85P53_22387025_ChIP-Seq_ESCs_Mouse1.06005138
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05089220
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04466238
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03678259
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.03678259
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03056601
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02090831
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01075261
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00151717
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99614876
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.99557162
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98999154
97P300_18555785_Chip-Seq_ESCs_Mouse0.98851643
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.98444227
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.97753785
100RXR_22108803_ChIP-Seq_LS180_Human0.97509548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.61132727
2MP0008057_abnormal_DNA_replication3.51122407
3MP0003195_calcinosis3.41321669
4MP0003646_muscle_fatigue2.93670859
5MP0001501_abnormal_sleep_pattern2.86916551
6MP0005551_abnormal_eye_electrophysiolog2.60340606
7MP0008877_abnormal_DNA_methylation2.55721240
8MP0009046_muscle_twitch2.55020017
9MP0002102_abnormal_ear_morphology2.49175874
10MP0004147_increased_porphyrin_level2.20000728
11MP0001968_abnormal_touch/_nociception2.17647032
12MP0005645_abnormal_hypothalamus_physiol2.05427254
13MP0004043_abnormal_pH_regulation2.03166257
14MP0002736_abnormal_nociception_after2.02132372
15MP0003136_yellow_coat_color1.97231446
16MP0002735_abnormal_chemical_nociception1.93042242
17MP0001485_abnormal_pinna_reflex1.91847202
18MP0008872_abnormal_physiological_respon1.91118024
19MP0009745_abnormal_behavioral_response1.88825342
20MP0006276_abnormal_autonomic_nervous1.87718494
21MP0003950_abnormal_plasma_membrane1.87658402
22MP0005646_abnormal_pituitary_gland1.77029006
23MP0005167_abnormal_blood-brain_barrier1.74280428
24MP0005253_abnormal_eye_physiology1.73173466
25MP0002837_dystrophic_cardiac_calcinosis1.71179532
26MP0001486_abnormal_startle_reflex1.69651979
27MP0000427_abnormal_hair_cycle1.66668665
28MP0003045_fibrosis1.62480253
29MP0002138_abnormal_hepatobiliary_system1.57975706
30MP0010386_abnormal_urinary_bladder1.50254973
31MP0000383_abnormal_hair_follicle1.46359982
32MP0005377_hearing/vestibular/ear_phenot1.45114086
33MP0003878_abnormal_ear_physiology1.45114086
34MP0001984_abnormal_olfaction1.44576713
35MP0005670_abnormal_white_adipose1.42674322
36MP0004145_abnormal_muscle_electrophysio1.41395907
37MP0002272_abnormal_nervous_system1.40860262
38MP0004142_abnormal_muscle_tone1.40412402
39MP0002733_abnormal_thermal_nociception1.40361018
40MP0003718_maternal_effect1.39374159
41MP0006292_abnormal_olfactory_placode1.36887998
42MP0002638_abnormal_pupillary_reflex1.35324021
43MP0003890_abnormal_embryonic-extraembry1.33901838
44MP0001970_abnormal_pain_threshold1.31403672
45MP0000631_abnormal_neuroendocrine_gland1.29998085
46MP0002572_abnormal_emotion/affect_behav1.29961559
47MP0003787_abnormal_imprinting1.27986383
48MP0002938_white_spotting1.27394824
49MP0004215_abnormal_myocardial_fiber1.27293696
50MP0005386_behavior/neurological_phenoty1.26718963
51MP0004924_abnormal_behavior1.26718963
52MP0002067_abnormal_sensory_capabilities1.22948208
53MP0002064_seizures1.22630697
54MP0009697_abnormal_copulation1.19881414
55MP0000372_irregular_coat_pigmentation1.19435619
56MP0006072_abnormal_retinal_apoptosis1.19379637
57MP0005174_abnormal_tail_pigmentation1.18789367
58MP0000230_abnormal_systemic_arterial1.15289405
59MP0002928_abnormal_bile_duct1.13865064
60MP0005085_abnormal_gallbladder_physiolo1.12926146
61MP0002557_abnormal_social/conspecific_i1.10321553
62MP0002876_abnormal_thyroid_physiology1.09590247
63MP0006054_spinal_hemorrhage1.08545430
64MP0002168_other_aberrant_phenotype1.07899856
65MP0003635_abnormal_synaptic_transmissio1.07337551
66MP0008961_abnormal_basal_metabolism1.05764561
67MP0005266_abnormal_metabolism1.03858933
68MP0003252_abnormal_bile_duct1.00959176
69MP0005395_other_phenotype1.00178376
70MP0002822_catalepsy0.98292818
71MP0005410_abnormal_fertilization0.96968939
72MP0003698_abnormal_male_reproductive0.96867463
73MP0005310_abnormal_salivary_gland0.96306291
74MP0008058_abnormal_DNA_repair0.94961055
75MP0002653_abnormal_ependyma_morphology0.94903675
76MP0005171_absent_coat_pigmentation0.93924224
77MP0000538_abnormal_urinary_bladder0.93504007
78MP0002229_neurodegeneration0.93030112
79MP0004085_abnormal_heartbeat0.92324774
80MP0003119_abnormal_digestive_system0.91863969
81MP0005195_abnormal_posterior_eye0.89262126
82MP0003880_abnormal_central_pattern0.89212324
83MP0003137_abnormal_impulse_conducting0.87077778
84MP0003633_abnormal_nervous_system0.85949939
85MP0002234_abnormal_pharynx_morphology0.85474774
86MP0002160_abnormal_reproductive_system0.84307112
87MP0002063_abnormal_learning/memory/cond0.84193459
88MP0005647_abnormal_sex_gland0.83111718
89MP0005075_abnormal_melanosome_morpholog0.82919841
90MP0001529_abnormal_vocalization0.82762483
91MP0008995_early_reproductive_senescence0.82721513
92MP0001986_abnormal_taste_sensitivity0.81124363
93MP0001764_abnormal_homeostasis0.80085354
94MP0001963_abnormal_hearing_physiology0.79572417
95MP0003943_abnormal_hepatobiliary_system0.79198593
96MP0003937_abnormal_limbs/digits/tail_de0.78324769
97MP0001929_abnormal_gametogenesis0.77935832
98MP0002752_abnormal_somatic_nervous0.75590143
99MP0001440_abnormal_grooming_behavior0.74773666
100MP0005389_reproductive_system_phenotype0.74107906

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.71063352
2Hyperventilation (HP:0002883)4.66647056
3Genetic anticipation (HP:0003743)4.48547410
4Gaze-evoked nystagmus (HP:0000640)4.15945198
5Pancreatic fibrosis (HP:0100732)3.99430310
6True hermaphroditism (HP:0010459)3.79539854
7Attenuation of retinal blood vessels (HP:0007843)3.75078016
8Abnormality of midbrain morphology (HP:0002418)3.58830161
9Molar tooth sign on MRI (HP:0002419)3.58830161
10Congenital stationary night blindness (HP:0007642)3.56673489
11Progressive cerebellar ataxia (HP:0002073)3.56614772
12Nephronophthisis (HP:0000090)3.39402432
13Chronic hepatic failure (HP:0100626)3.15542584
14Abnormality of the renal cortex (HP:0011035)3.15083121
15Abnormality of the renal medulla (HP:0100957)3.13206962
16Cystic liver disease (HP:0006706)3.02813403
17Birth length less than 3rd percentile (HP:0003561)3.00294077
18Clumsiness (HP:0002312)2.95554040
19Type II lissencephaly (HP:0007260)2.93741602
20Protruding tongue (HP:0010808)2.90988029
21Abolished electroretinogram (ERG) (HP:0000550)2.84377059
22Medial flaring of the eyebrow (HP:0010747)2.77702330
23Central scotoma (HP:0000603)2.72180723
24Bony spicule pigmentary retinopathy (HP:0007737)2.71502352
25Inability to walk (HP:0002540)2.68360999
26Febrile seizures (HP:0002373)2.62081020
27Increased corneal curvature (HP:0100692)2.60450649
28Keratoconus (HP:0000563)2.60450649
29Fair hair (HP:0002286)2.58718282
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57227946
31Absent speech (HP:0001344)2.56603511
32Cerebellar dysplasia (HP:0007033)2.55743931
33Tubular atrophy (HP:0000092)2.49730684
34Broad-based gait (HP:0002136)2.49064418
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.47444275
36Decreased circulating renin level (HP:0003351)2.41411311
37Patellar aplasia (HP:0006443)2.38371169
38Decreased central vision (HP:0007663)2.37281051
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.34833439
40Dialeptic seizures (HP:0011146)2.34584365
41Focal seizures (HP:0007359)2.34526248
42Congenital sensorineural hearing impairment (HP:0008527)2.33430298
43Pendular nystagmus (HP:0012043)2.30963544
44Gait imbalance (HP:0002141)2.29095338
45Sclerocornea (HP:0000647)2.27415178
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.26461428
47Congenital primary aphakia (HP:0007707)2.26358105
48Congenital hepatic fibrosis (HP:0002612)2.25366414
49Widely spaced teeth (HP:0000687)2.22145767
50Progressive inability to walk (HP:0002505)2.20562220
51Aplasia/Hypoplasia of the patella (HP:0006498)2.18566193
52Scotoma (HP:0000575)2.18091682
53Abnormal drinking behavior (HP:0030082)2.15920742
54Polydipsia (HP:0001959)2.15920742
55Abnormal rod and cone electroretinograms (HP:0008323)2.15656985
56Abnormal ciliary motility (HP:0012262)2.15402526
57Furrowed tongue (HP:0000221)2.14625068
58Stomach cancer (HP:0012126)2.13971401
59Abnormality of alanine metabolism (HP:0010916)2.12070812
60Hyperalaninemia (HP:0003348)2.12070812
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12070812
62Focal motor seizures (HP:0011153)2.09892922
63Small hand (HP:0200055)2.09407740
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08590041
65Abnormal biliary tract physiology (HP:0012439)2.07295827
66Bile duct proliferation (HP:0001408)2.07295827
67Lissencephaly (HP:0001339)2.05905972
68Large for gestational age (HP:0001520)2.05559888
69Nephrogenic diabetes insipidus (HP:0009806)2.05337561
70Anencephaly (HP:0002323)2.03829945
71Hypothermia (HP:0002045)2.02068925
72Genital tract atresia (HP:0001827)2.01820329
73Retinal dysplasia (HP:0007973)2.00206274
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00111719
75Abnormality of the pons (HP:0007361)1.97012043
76Constricted visual fields (HP:0001133)1.95958369
77Hypoplasia of the pons (HP:0012110)1.94958962
78Vaginal atresia (HP:0000148)1.91739908
79Abnormality of macular pigmentation (HP:0008002)1.91508860
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.90678046
81Absent/shortened dynein arms (HP:0200106)1.90678046
82Intestinal atresia (HP:0011100)1.88099636
83Postaxial foot polydactyly (HP:0001830)1.86454000
84Generalized hypopigmentation of hair (HP:0011358)1.84985246
85Thyroid-stimulating hormone excess (HP:0002925)1.83887459
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.83456094
87Absence seizures (HP:0002121)1.82987626
88Facial diplegia (HP:0001349)1.82349719
89Chorioretinal atrophy (HP:0000533)1.80325572
90Poor coordination (HP:0002370)1.79621301
91Short foot (HP:0001773)1.79502446
92Renal cortical cysts (HP:0000803)1.78918329
93Tubulointerstitial nephritis (HP:0001970)1.77285468
94Urinary bladder sphincter dysfunction (HP:0002839)1.77041965
95Chromsome breakage (HP:0040012)1.75096605
96Astigmatism (HP:0000483)1.74159956
97Retinitis pigmentosa (HP:0000510)1.73950282
98Abnormal respiratory motile cilium physiology (HP:0012261)1.73758263
99Sloping forehead (HP:0000340)1.73472329
100Abnormality of the renal collecting system (HP:0004742)1.72423816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.06221545
2ACVR1B4.00622259
3BMPR1B3.54169173
4ADRBK22.57929727
5ZAK2.41859718
6INSRR2.32492908
7STK38L2.12157985
8CASK2.11498128
9NUAK12.10374263
10WNK31.77921351
11MKNK21.74838283
12TAOK31.70701653
13MAP3K41.67063110
14MAPK131.63754278
15GRK11.61883134
16DAPK21.60751407
17LATS11.52690462
18TNIK1.51758150
19MAP4K21.48027307
20ADRBK11.36330540
21OXSR11.36225509
22PIK3CG1.35078176
23PINK11.21548645
24TGFBR11.17498434
25STK391.16386018
26TEC1.12130546
27AKT31.06552956
28PTK2B1.01514536
29NLK0.98554051
30NTRK30.98265042
31STK30.95242514
32TNK20.95125415
33WNK40.92470073
34TIE10.90991493
35TXK0.82400873
36MKNK10.82048373
37TRIM280.81091727
38BRSK20.80305873
39PRKCE0.79592857
40CAMKK20.77038959
41PAK30.75066716
42MAP2K70.70766815
43CAMK1D0.70527663
44PRKCG0.68948705
45EIF2AK30.68312080
46CAMK1G0.67736414
47MELK0.66997324
48PRKAA20.66275821
49IRAK10.65442268
50TLK10.63668522
51FER0.60663077
52OBSCN0.58315918
53NME10.57011224
54STK380.56908037
55PLK20.56719867
56SGK20.56420553
57PLK40.54952648
58MAP3K70.53851075
59CSNK1A1L0.53778093
60KIT0.53307814
61CAMK2A0.50537583
62MARK10.50506878
63CSNK1G10.50016779
64PKN10.49877903
65MUSK0.49505225
66GRK70.49463972
67CAMK10.47537206
68FGFR20.47461959
69PIK3CA0.46466621
70NEK20.44766335
71BCKDK0.43560032
72MAP2K60.43470104
73BCR0.43296185
74PRKAA10.42350738
75CAMK40.42327590
76IKBKB0.41073703
77CSNK1D0.39778687
78BRD40.37091192
79CHEK20.37071712
80CSNK1G20.36991699
81MST40.36808854
82CHUK0.36577263
83SIK20.36207769
84ATR0.35948386
85MAP2K10.35435929
86STK110.35177441
87WNK10.34601028
88PBK0.33443626
89PRKCH0.33361041
90ITK0.32659943
91PRKCQ0.31764772
92PRKACA0.31377143
93PRKACB0.30637458
94VRK10.30356628
95CSNK1G30.30332318
96CSNK1A10.29757049
97GRK50.29419971
98ATM0.29084328
99RPS6KA50.28929884
100PLK10.28888523

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.94160179
2Phototransduction_Homo sapiens_hsa047442.81348397
3Nicotine addiction_Homo sapiens_hsa050332.58874461
4ABC transporters_Homo sapiens_hsa020102.46408638
5Tryptophan metabolism_Homo sapiens_hsa003802.44912262
6Homologous recombination_Homo sapiens_hsa034402.41416985
7Linoleic acid metabolism_Homo sapiens_hsa005912.35692512
8Nitrogen metabolism_Homo sapiens_hsa009102.30551605
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28724079
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16956475
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07473256
12Taste transduction_Homo sapiens_hsa047422.03237570
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00462786
14Morphine addiction_Homo sapiens_hsa050321.77927685
15Propanoate metabolism_Homo sapiens_hsa006401.76505062
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74164605
17Ether lipid metabolism_Homo sapiens_hsa005651.71220678
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69001926
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68664185
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.68143564
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65589565
22Fanconi anemia pathway_Homo sapiens_hsa034601.63263181
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.61726057
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56126126
25Serotonergic synapse_Homo sapiens_hsa047261.55309228
26Olfactory transduction_Homo sapiens_hsa047401.54869834
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53492462
28Selenocompound metabolism_Homo sapiens_hsa004501.52701029
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52651575
30Circadian entrainment_Homo sapiens_hsa047131.41297635
31Glutamatergic synapse_Homo sapiens_hsa047241.39134551
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.38526291
33GABAergic synapse_Homo sapiens_hsa047271.38153328
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28225299
35Retinol metabolism_Homo sapiens_hsa008301.27497059
36Chemical carcinogenesis_Homo sapiens_hsa052041.26992451
37Lysine degradation_Homo sapiens_hsa003101.26421039
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26342652
39beta-Alanine metabolism_Homo sapiens_hsa004101.24604132
40Calcium signaling pathway_Homo sapiens_hsa040201.21146935
41Ovarian steroidogenesis_Homo sapiens_hsa049131.21076924
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19983486
43Glycerolipid metabolism_Homo sapiens_hsa005611.18050195
44Salivary secretion_Homo sapiens_hsa049701.15540306
45Basal transcription factors_Homo sapiens_hsa030221.13660855
46Caffeine metabolism_Homo sapiens_hsa002321.09228409
47Histidine metabolism_Homo sapiens_hsa003401.06532055
48RNA polymerase_Homo sapiens_hsa030201.03110538
49Insulin secretion_Homo sapiens_hsa049110.99034979
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.98530785
51Non-homologous end-joining_Homo sapiens_hsa034500.95083605
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95082899
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92068605
54One carbon pool by folate_Homo sapiens_hsa006700.89854022
55Arachidonic acid metabolism_Homo sapiens_hsa005900.88287590
56Long-term depression_Homo sapiens_hsa047300.85179720
57Sphingolipid metabolism_Homo sapiens_hsa006000.84985301
58Dorso-ventral axis formation_Homo sapiens_hsa043200.80751527
59Fatty acid degradation_Homo sapiens_hsa000710.77781034
60Circadian rhythm_Homo sapiens_hsa047100.76212486
61Cholinergic synapse_Homo sapiens_hsa047250.74928604
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.74375704
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68112557
64Oxytocin signaling pathway_Homo sapiens_hsa049210.67468840
65Purine metabolism_Homo sapiens_hsa002300.67444001
66Peroxisome_Homo sapiens_hsa041460.63785501
67RNA degradation_Homo sapiens_hsa030180.63690913
68Regulation of autophagy_Homo sapiens_hsa041400.61578883
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.61150674
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60623628
71cAMP signaling pathway_Homo sapiens_hsa040240.58947404
72Dopaminergic synapse_Homo sapiens_hsa047280.55845551
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55547707
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54853129
75Gastric acid secretion_Homo sapiens_hsa049710.53261772
76Fatty acid biosynthesis_Homo sapiens_hsa000610.51983230
77Renin secretion_Homo sapiens_hsa049240.48735690
78Vitamin digestion and absorption_Homo sapiens_hsa049770.47362261
79Type II diabetes mellitus_Homo sapiens_hsa049300.45216476
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40249534
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39932276
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39930358
83Platelet activation_Homo sapiens_hsa046110.38959102
84Metabolic pathways_Homo sapiens_hsa011000.38394441
85Asthma_Homo sapiens_hsa053100.38361791
86Graft-versus-host disease_Homo sapiens_hsa053320.36938235
87Pancreatic secretion_Homo sapiens_hsa049720.36667156
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35530505
89Fatty acid metabolism_Homo sapiens_hsa012120.34384808
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31002795
91Bile secretion_Homo sapiens_hsa049760.30751594
92Cocaine addiction_Homo sapiens_hsa050300.30443701
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.30191667
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29709506
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29539171
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27633897
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26113765
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26097076
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24750799
100Fat digestion and absorption_Homo sapiens_hsa049750.22363107

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