ZNF671

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.83324208
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83324208
3regulation of B cell receptor signaling pathway (GO:0050855)4.62842990
4positive regulation of gamma-delta T cell activation (GO:0046645)4.46703178
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13305076
6tachykinin receptor signaling pathway (GO:0007217)4.11868754
7immunoglobulin mediated immune response (GO:0016064)3.85698156
8B cell receptor signaling pathway (GO:0050853)3.60387625
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58165184
10positive regulation of B cell differentiation (GO:0045579)3.50124725
11negative thymic T cell selection (GO:0045060)3.46856424
12regulation of B cell differentiation (GO:0045577)3.44994654
13activated T cell proliferation (GO:0050798)3.41661993
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34987948
15positive regulation of granulocyte differentiation (GO:0030854)3.34900933
16negative T cell selection (GO:0043383)3.30896363
17positive T cell selection (GO:0043368)3.28957145
18negative regulation of mast cell activation (GO:0033004)3.24260644
19T cell migration (GO:0072678)3.22241078
20positive thymic T cell selection (GO:0045059)3.20760127
21cellular response to interleukin-15 (GO:0071350)3.15929291
22pyrimidine nucleobase catabolic process (GO:0006208)3.15217041
23neural tube formation (GO:0001841)3.13349779
24positive regulation of action potential (GO:0045760)3.02101737
25regulation of mast cell activation (GO:0033003)3.00603032
26negative regulation of lymphocyte mediated immunity (GO:0002707)2.99199263
27aggressive behavior (GO:0002118)2.97690694
28interferon-gamma production (GO:0032609)2.95921643
29regulation of gamma-delta T cell activation (GO:0046643)2.95107384
30positive regulation of oligodendrocyte differentiation (GO:0048714)2.93924650
31negative regulation of leukocyte mediated immunity (GO:0002704)2.93746675
32regulation of germinal center formation (GO:0002634)2.92879093
33B cell mediated immunity (GO:0019724)2.87535770
34adaptation of signaling pathway (GO:0023058)2.86193364
35regulation of gamma-delta T cell differentiation (GO:0045586)2.84931754
36tolerance induction (GO:0002507)2.82900381
37response to interleukin-15 (GO:0070672)2.82633438
38response to peptidoglycan (GO:0032494)2.81446351
39regulation of cilium movement (GO:0003352)2.78847757
40antigen processing and presentation of endogenous antigen (GO:0019883)2.74565022
41regulation of alpha-beta T cell proliferation (GO:0046640)2.74186413
42inositol phosphate catabolic process (GO:0071545)2.72410649
43neutrophil mediated immunity (GO:0002446)2.70329259
44T cell selection (GO:0045058)2.70168596
45positive regulation of uterine smooth muscle contraction (GO:0070474)2.66930564
46regulation of action potential (GO:0098900)2.66595862
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65888323
48positive regulation by organism of defense response of other organism involved in symbiotic interact2.65888323
49modulation by symbiont of host immune response (GO:0052553)2.65888323
50positive regulation by symbiont of host defense response (GO:0052509)2.65888323
51modulation by symbiont of host defense response (GO:0052031)2.65888323
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65888323
53response to muramyl dipeptide (GO:0032495)2.63077192
54regulation of antigen processing and presentation (GO:0002577)2.62074297
55interferon-gamma-mediated signaling pathway (GO:0060333)2.61736904
56antigen receptor-mediated signaling pathway (GO:0050851)2.58883973
57regulation of mast cell activation involved in immune response (GO:0033006)2.58076071
58defense response to protozoan (GO:0042832)2.58064956
59pyrimidine dimer repair (GO:0006290)2.56621653
60presynaptic membrane assembly (GO:0097105)2.56178455
61histone H3-K9 modification (GO:0061647)2.55901818
62histone H3-K9 methylation (GO:0051567)2.54290398
63regulation of mast cell degranulation (GO:0043304)2.54199808
64positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51717276
65positive regulation of mast cell activation (GO:0033005)2.49398119
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49015273
67RNA destabilization (GO:0050779)2.46354981
68cellular extravasation (GO:0045123)2.45660337
69regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.45464585
70neutrophil activation involved in immune response (GO:0002283)2.45317425
71germinal center formation (GO:0002467)2.45106412
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.43359879
73positive regulation of interleukin-2 production (GO:0032743)2.41572599
74DNA double-strand break processing (GO:0000729)2.38825504
75positive regulation of T cell cytokine production (GO:0002726)2.38597964
76microglial cell activation (GO:0001774)2.38131215
77neutrophil activation (GO:0042119)2.37247537
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.36897757
79negative regulation of protein oligomerization (GO:0032460)2.36571885
80negative regulation of T cell mediated immunity (GO:0002710)2.35662425
81myeloid leukocyte mediated immunity (GO:0002444)2.35404512
82regulation of heat generation (GO:0031650)2.35174836
83response to auditory stimulus (GO:0010996)2.33215432
84macrophage activation involved in immune response (GO:0002281)2.33152104
85response to protozoan (GO:0001562)2.32802235
86detection of bacterium (GO:0016045)2.32782612
87detection of other organism (GO:0098543)2.32370876
88neuron cell-cell adhesion (GO:0007158)2.32341086
89regulation of feeding behavior (GO:0060259)2.32295359
90retinal cone cell development (GO:0046549)2.30245342
91glycosphingolipid biosynthetic process (GO:0006688)2.29828935
92regulation of interleukin-6 biosynthetic process (GO:0045408)2.29682744
93positive regulation of interleukin-17 production (GO:0032740)2.27815665
94nucleobase catabolic process (GO:0046113)2.27277187
95response to host immune response (GO:0052572)2.26814245
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.26814245
97negative regulation of type 2 immune response (GO:0002829)2.25956644
98tyrosine phosphorylation of STAT protein (GO:0007260)2.25464383
99regulation of mitochondrial depolarization (GO:0051900)2.25451802
100adenosine metabolic process (GO:0046085)2.25253051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.96882973
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57909295
3EZH2_22144423_ChIP-Seq_EOC_Human3.28584722
4ZNF274_21170338_ChIP-Seq_K562_Hela3.11526960
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00328182
6GBX2_23144817_ChIP-Seq_PC3_Human2.91737245
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.44497830
8IGF1R_20145208_ChIP-Seq_DFB_Human2.41672634
9RUNX_20019798_ChIP-Seq_JUKART_Human2.27154560
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25240329
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19003233
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18164163
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.11378396
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08135327
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.03774676
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98343978
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95532300
18CIITA_25753668_ChIP-Seq_RAJI_Human1.94893084
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91097294
20SCL_19346495_ChIP-Seq_HPC-7_Human1.81393130
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78328390
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75348166
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72682167
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.72490118
25MYB_26560356_Chip-Seq_TH2_Human1.68646821
26GATA3_27048872_Chip-Seq_THYMUS_Human1.57669884
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53647908
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.51417808
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47434707
30CBP_20019798_ChIP-Seq_JUKART_Human1.47434707
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.43823359
32REST_21632747_ChIP-Seq_MESCs_Mouse1.42548624
33VDR_24787735_ChIP-Seq_THP-1_Human1.41108312
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38526745
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38069557
36GATA3_26560356_Chip-Seq_TH2_Human1.37045361
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35048866
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33582510
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32864520
40IRF1_19129219_ChIP-ChIP_H3396_Human1.32043736
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.31627961
42SPI1_23547873_ChIP-Seq_NB4_Human1.31584058
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.31553558
44TAF15_26573619_Chip-Seq_HEK293_Human1.30925473
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28152776
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26337095
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26243367
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25959650
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25767235
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25636495
51SPI1_23127762_ChIP-Seq_K562_Human1.24773047
52TP53_22573176_ChIP-Seq_HFKS_Human1.24699316
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.23951432
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18284494
55VDR_22108803_ChIP-Seq_LS180_Human1.18188879
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.17883641
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17543968
58* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16970363
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16273516
60MYB_26560356_Chip-Seq_TH1_Human1.11662180
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11650735
62P300_19829295_ChIP-Seq_ESCs_Human1.11030067
63SMAD4_21799915_ChIP-Seq_A2780_Human1.08897458
64VDR_23849224_ChIP-Seq_CD4+_Human1.08391678
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05557440
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05137076
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02598435
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01784479
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01281187
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00349426
71RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99807760
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99407339
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98714668
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97529641
75STAT3_23295773_ChIP-Seq_U87_Human0.97510606
76TCF4_23295773_ChIP-Seq_U87_Human0.97494422
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97432760
78AR_25329375_ChIP-Seq_VCAP_Human0.97162165
79UTX_26944678_Chip-Seq_JUKART_Human0.97037754
80ER_23166858_ChIP-Seq_MCF-7_Human0.96938294
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96669465
82SMRT_27268052_Chip-Seq_Bcells_Human0.96589581
83BCAT_22108803_ChIP-Seq_LS180_Human0.96267075
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95035252
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.94346825
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94143659
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94143659
88FUS_26573619_Chip-Seq_HEK293_Human0.93941510
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93811739
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92766339
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92025486
92RNF2_27304074_Chip-Seq_NSC_Mouse0.90991598
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90761413
94DROSHA_22980978_ChIP-Seq_HELA_Human0.90615946
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90023609
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.89206131
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89162312
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87758516
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.84206328
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83548805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.90357368
2MP0003724_increased_susceptibility_to3.26189503
3MP0001968_abnormal_touch/_nociception2.89854821
4MP0008877_abnormal_DNA_methylation2.87435363
5MP0003787_abnormal_imprinting2.69388349
6MP0003436_decreased_susceptibility_to2.68636628
7MP0002735_abnormal_chemical_nociception2.46882207
8MP0001835_abnormal_antigen_presentation2.44829814
9MP0001986_abnormal_taste_sensitivity2.28034693
10MP0001800_abnormal_humoral_immune2.26331466
11MP0002138_abnormal_hepatobiliary_system2.15396443
12MP0002102_abnormal_ear_morphology2.06426324
13MP0005671_abnormal_response_to2.05159672
14MP0002736_abnormal_nociception_after2.02326133
15MP0005084_abnormal_gallbladder_morpholo1.98200638
16MP0001529_abnormal_vocalization1.98158572
17MP0005000_abnormal_immune_tolerance1.93384268
18MP0000465_gastrointestinal_hemorrhage1.81961737
19MP0003880_abnormal_central_pattern1.78367488
20MP0002723_abnormal_immune_serum1.73608648
21MP0002420_abnormal_adaptive_immunity1.67408654
22MP0001819_abnormal_immune_cell1.63725783
23MP0004142_abnormal_muscle_tone1.61524744
24MP0002277_abnormal_respiratory_mucosa1.60245363
25MP0001984_abnormal_olfaction1.59858889
26MP0002452_abnormal_antigen_presenting1.58952144
27MP0002419_abnormal_innate_immunity1.58221760
28MP0003656_abnormal_erythrocyte_physiolo1.55468441
29MP0003763_abnormal_thymus_physiology1.53256811
30MP0001790_abnormal_immune_system1.53233198
31MP0005387_immune_system_phenotype1.53233198
32MP0005025_abnormal_response_to1.46775997
33MP0000604_amyloidosis1.38671245
34MP0000685_abnormal_immune_system1.37920909
35MP0003635_abnormal_synaptic_transmissio1.36314775
36MP0000689_abnormal_spleen_morphology1.35366613
37MP0002398_abnormal_bone_marrow1.34938462
38MP0003329_amyloid_beta_deposits1.34623599
39MP0009764_decreased_sensitivity_to1.32789410
40MP0005075_abnormal_melanosome_morpholog1.32721735
41MP0000716_abnormal_immune_system1.27428837
42MP0005464_abnormal_platelet_physiology1.26041275
43MP0003172_abnormal_lysosome_physiology1.20612487
44MP0002722_abnormal_immune_system1.18321052
45MP0002148_abnormal_hypersensitivity_rea1.16761316
46MP0009785_altered_susceptibility_to1.14995492
47MP0009745_abnormal_behavioral_response1.14035068
48MP0001545_abnormal_hematopoietic_system1.13419821
49MP0005397_hematopoietic_system_phenotyp1.13419821
50MP0002405_respiratory_system_inflammati1.12531961
51MP0003183_abnormal_peptide_metabolism1.12516406
52MP0002653_abnormal_ependyma_morphology1.12181636
53MP0004924_abnormal_behavior1.10959117
54MP0005386_behavior/neurological_phenoty1.10959117
55MP0006082_CNS_inflammation1.07300611
56MP0005310_abnormal_salivary_gland1.06842291
57MP0000703_abnormal_thymus_morphology1.05909058
58MP0004859_abnormal_synaptic_plasticity1.04227304
59MP0003646_muscle_fatigue1.03484531
60MP0001533_abnormal_skeleton_physiology1.03356807
61MP0005423_abnormal_somatic_nervous1.02396672
62MP0004145_abnormal_muscle_electrophysio1.01410136
63MP0002733_abnormal_thermal_nociception1.01172373
64MP0002572_abnormal_emotion/affect_behav0.98827493
65MP0002822_catalepsy0.98432168
66MP0004885_abnormal_endolymph0.98363719
67MP0002063_abnormal_learning/memory/cond0.97479554
68MP0008995_early_reproductive_senescence0.97165163
69MP0002254_reproductive_system_inflammat0.94164049
70MP0002067_abnormal_sensory_capabilities0.93510127
71MP0002734_abnormal_mechanical_nocicepti0.93410664
72MP0000516_abnormal_urinary_system0.93400096
73MP0005367_renal/urinary_system_phenotyp0.93400096
74MP0001845_abnormal_inflammatory_respons0.92871871
75MP0001970_abnormal_pain_threshold0.91851780
76MP0004883_abnormal_blood_vessel0.90783219
77MP0002429_abnormal_blood_cell0.90451469
78MP0002064_seizures0.89937822
79MP0002837_dystrophic_cardiac_calcinosis0.86460053
80MP0005253_abnormal_eye_physiology0.85068864
81MP0009278_abnormal_bone_marrow0.84186185
82MP0004130_abnormal_muscle_cell0.84150716
83MP0001486_abnormal_startle_reflex0.83622575
84MP0006054_spinal_hemorrhage0.83442434
85MP0005535_abnormal_body_temperature0.82795260
86MP0003806_abnormal_nucleotide_metabolis0.81777861
87MP0002928_abnormal_bile_duct0.80727710
88MP0005220_abnormal_exocrine_pancreas0.80315987
89MP0004484_altered_response_of0.80070069
90MP0005551_abnormal_eye_electrophysiolog0.78792457
91MP0004270_analgesia0.77839402
92MP0005394_taste/olfaction_phenotype0.77640962
93MP0005499_abnormal_olfactory_system0.77640962
94MP0009046_muscle_twitch0.75936833
95MP0003828_pulmonary_edema0.75185174
96MP0005645_abnormal_hypothalamus_physiol0.74204749
97MP0004811_abnormal_neuron_physiology0.74082083
98MP0002638_abnormal_pupillary_reflex0.72875436
99MP0002332_abnormal_exercise_endurance0.72791466
100MP0002396_abnormal_hematopoietic_system0.72706663

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.86679196
2Amyotrophic lateral sclerosis (HP:0007354)4.43278483
3Methylmalonic acidemia (HP:0002912)4.03321860
4Papilledema (HP:0001085)4.02794499
5Methylmalonic aciduria (HP:0012120)3.98466814
6Stomach cancer (HP:0012126)3.69101295
7Chronic mucocutaneous candidiasis (HP:0002728)3.51942461
8Recurrent cutaneous fungal infections (HP:0011370)3.51942461
9Polyphagia (HP:0002591)3.38716799
10Panhypogammaglobulinemia (HP:0003139)3.25873141
11Recurrent bacterial skin infections (HP:0005406)3.15529648
12Recurrent abscess formation (HP:0002722)3.15355348
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.12651095
14Mediastinal lymphadenopathy (HP:0100721)3.12274403
15Recurrent fungal infections (HP:0002841)3.11454368
16Meningitis (HP:0001287)2.87179630
17Agammaglobulinemia (HP:0004432)2.84983038
18Hyperventilation (HP:0002883)2.74789929
19Absent speech (HP:0001344)2.73838582
20Elevated erythrocyte sedimentation rate (HP:0003565)2.69120171
21Encephalitis (HP:0002383)2.63253805
22Severe combined immunodeficiency (HP:0004430)2.61650224
23Gait imbalance (HP:0002141)2.47421671
24Recurrent skin infections (HP:0001581)2.47356110
25Atrophy/Degeneration involving motor neurons (HP:0007373)2.44124813
26Medial flaring of the eyebrow (HP:0010747)2.42921054
27IgG deficiency (HP:0004315)2.36029250
28Leukocytosis (HP:0001974)2.35538975
29Eczematoid dermatitis (HP:0000976)2.34297552
30Nephrogenic diabetes insipidus (HP:0009806)2.33077795
31Thyroiditis (HP:0100646)2.29490716
32Optic neuritis (HP:0100653)2.29123807
33Retrobulbar optic neuritis (HP:0100654)2.29123807
34Chest pain (HP:0100749)2.28876406
35Abnormality of eosinophils (HP:0001879)2.26930475
36Abnormality of macrophages (HP:0004311)2.26921014
37Abnormality of T cells (HP:0002843)2.26159308
38Abnormality of vitamin B metabolism (HP:0004340)2.24992272
39T lymphocytopenia (HP:0005403)2.24691001
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.21512365
41Myositis (HP:0100614)2.19991256
42Hemiplegia (HP:0002301)2.19588917
43Agnosia (HP:0010524)2.17138677
44Congenital primary aphakia (HP:0007707)2.15078805
45Abnormality of the prostate (HP:0008775)2.13355175
46Hemiparesis (HP:0001269)2.12496602
47Abnormality of T cell number (HP:0011839)2.10848781
48Pulmonary infiltrates (HP:0002113)2.08288383
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07040796
50Dicarboxylic aciduria (HP:0003215)2.07040796
51Hematochezia (HP:0002573)2.06821977
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.06596946
53Agitation (HP:0000713)2.06418142
54Recurrent sinusitis (HP:0011108)2.05039713
55Eosinophilia (HP:0001880)2.03603510
56Urticaria (HP:0001025)2.03153983
57Abnormality of T cell physiology (HP:0011840)2.01963339
58Increased IgM level (HP:0003496)2.00217233
59Orchitis (HP:0100796)1.98578442
60Abnormal eating behavior (HP:0100738)1.96478366
61Keratoconjunctivitis (HP:0001096)1.95469624
62Vasculitis (HP:0002633)1.93607844
63Hip dysplasia (HP:0001385)1.92518652
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91956444
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.91956444
66Tented upper lip vermilion (HP:0010804)1.90173883
67Hypochromic microcytic anemia (HP:0004840)1.89826220
68Hemoptysis (HP:0002105)1.89364880
69Combined immunodeficiency (HP:0005387)1.87752931
70Asplenia (HP:0001746)1.87720492
71Abolished electroretinogram (ERG) (HP:0000550)1.84743284
72Granulocytopenia (HP:0001913)1.81470422
73IgM deficiency (HP:0002850)1.80965771
74Thyroid-stimulating hormone excess (HP:0002925)1.80661898
75Recurrent viral infections (HP:0004429)1.80559459
76Dialeptic seizures (HP:0011146)1.80333835
77Abnormality of B cell number (HP:0010975)1.80240041
78Hyperglycinemia (HP:0002154)1.80142079
79Lissencephaly (HP:0001339)1.80025092
80Disinhibition (HP:0000734)1.79658346
81Attenuation of retinal blood vessels (HP:0007843)1.79615177
82Ankle clonus (HP:0011448)1.79039938
83Papilloma (HP:0012740)1.78838414
84Verrucae (HP:0200043)1.78838414
85Chronic diarrhea (HP:0002028)1.77905835
86Oligomenorrhea (HP:0000876)1.77712109
87Intestinal atresia (HP:0011100)1.77665936
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.77569709
89Alveolar cell carcinoma (HP:0006519)1.77088878
90Broad-based gait (HP:0002136)1.76657423
91Spastic gait (HP:0002064)1.73581851
92Keratoconjunctivitis sicca (HP:0001097)1.72615017
93Acute hepatic failure (HP:0006554)1.69910058
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69624468
95Ketosis (HP:0001946)1.69468175
96Atonic seizures (HP:0010819)1.69164904
97Lymphopenia (HP:0001888)1.68612560
98Chronic obstructive pulmonary disease (HP:0006510)1.68129527
99Obstructive lung disease (HP:0006536)1.68129527
100Focal motor seizures (HP:0011153)1.67123186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.32622608
2FES2.76202647
3TAOK32.55935778
4CASK2.48703863
5MAPK132.36756562
6TXK2.20538313
7SIK22.05008591
8CDK191.96049055
9ITK1.95769866
10KIT1.94502364
11MARK11.93325431
12TEC1.87413024
13FRK1.82949825
14BCKDK1.82318140
15SYK1.80897048
16GRK61.71921059
17WNK31.71092393
18MAP2K71.68268662
19BTK1.67240924
20MAP4K21.64718087
21CAMKK21.58463131
22TNK21.56734419
23PIM21.55269326
24IKBKE1.54260193
25MAP3K41.54011273
26BLK1.48890015
27NUAK11.47883223
28LYN1.45058055
29RIPK41.41162546
30DAPK21.36935478
31HCK1.36787031
32NTRK21.22888162
33MAP3K61.21104775
34DYRK21.13338165
35LCK1.12409626
36KDR1.12202372
37PINK11.10569638
38IRAK41.06463087
39IKBKB1.02172413
40JAK31.01478102
41MATK1.01350987
42PRKCQ1.01017996
43CSK1.00928799
44PIM10.96729893
45MAP3K50.94774698
46EPHA30.94541001
47FGR0.90828327
48DYRK1A0.89966780
49ZAP700.89764340
50ADRBK20.89163770
51SGK20.88798081
52PRPF4B0.88072822
53PLK20.86739999
54MAP2K40.84001912
55OBSCN0.83763730
56JAK20.82691572
57DYRK1B0.82169144
58CSF1R0.81169086
59TYK20.81134193
60MAP3K140.80318387
61CAMKK10.78600851
62ERBB30.76986056
63PIK3CG0.75856809
64SIK30.75011170
65GRK10.71931164
66TNIK0.68239318
67PHKG10.67129240
68PHKG20.67129240
69IRAK10.66608530
70SGK2230.66365338
71SGK4940.66365338
72GRK70.63628096
73TBK10.63345767
74FYN0.62111745
75CDK30.61785919
76MARK20.61604817
77CDK60.59211999
78STK110.58684741
79CSNK1G20.58236643
80MAPK120.57017729
81PRKCZ0.55920809
82EIF2AK30.55178731
83MAPK70.53737409
84ABL10.52523392
85PTK2B0.51448310
86PASK0.51187789
87PRKCE0.50554420
88BCR0.50515021
89MAP3K70.49575415
90JAK10.48858832
91CAMK40.47688578
92YES10.46953712
93CDK50.43372292
94PAK30.41427453
95RPS6KA50.41396153
96AKT30.41256004
97TAOK10.41194513
98CHUK0.40855756
99RPS6KA40.40301461
100MAP2K30.39065018

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.06092985
2Autoimmune thyroid disease_Homo sapiens_hsa053203.79027403
3Asthma_Homo sapiens_hsa053103.77671398
4Graft-versus-host disease_Homo sapiens_hsa053323.70570678
5Type I diabetes mellitus_Homo sapiens_hsa049403.68696139
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.60225068
7Leishmaniasis_Homo sapiens_hsa051402.82714335
8Primary immunodeficiency_Homo sapiens_hsa053402.72318967
9Staphylococcus aureus infection_Homo sapiens_hsa051502.20930432
10Viral myocarditis_Homo sapiens_hsa054162.10745708
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03921827
12Antigen processing and presentation_Homo sapiens_hsa046122.03742257
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87352008
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83665465
15Tuberculosis_Homo sapiens_hsa051521.80917579
16Rheumatoid arthritis_Homo sapiens_hsa053231.66821103
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51826021
18Osteoclast differentiation_Homo sapiens_hsa043801.49891557
19Herpes simplex infection_Homo sapiens_hsa051681.37964706
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37416068
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37059270
22B cell receptor signaling pathway_Homo sapiens_hsa046621.33653207
23T cell receptor signaling pathway_Homo sapiens_hsa046601.29766166
24Toxoplasmosis_Homo sapiens_hsa051451.28425737
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26481379
26Regulation of autophagy_Homo sapiens_hsa041401.26348640
27Measles_Homo sapiens_hsa051621.20345473
28Phagosome_Homo sapiens_hsa041451.17864115
29Hematopoietic cell lineage_Homo sapiens_hsa046401.11481472
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.09904376
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97021605
32Nicotine addiction_Homo sapiens_hsa050330.96663472
33Taste transduction_Homo sapiens_hsa047420.96474835
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95655605
35Circadian entrainment_Homo sapiens_hsa047130.92416825
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92236262
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91957990
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91751207
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90986857
40Morphine addiction_Homo sapiens_hsa050320.88458259
41GABAergic synapse_Homo sapiens_hsa047270.86679655
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.86539495
43Chemokine signaling pathway_Homo sapiens_hsa040620.85747114
44Influenza A_Homo sapiens_hsa051640.85541444
45Butanoate metabolism_Homo sapiens_hsa006500.84031680
46Long-term depression_Homo sapiens_hsa047300.82677353
47Dorso-ventral axis formation_Homo sapiens_hsa043200.79262170
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76142063
49Type II diabetes mellitus_Homo sapiens_hsa049300.74953765
50Phototransduction_Homo sapiens_hsa047440.73638761
51Legionellosis_Homo sapiens_hsa051340.67761152
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66855969
53African trypanosomiasis_Homo sapiens_hsa051430.65065638
54Glutamatergic synapse_Homo sapiens_hsa047240.63188991
55Other glycan degradation_Homo sapiens_hsa005110.62671948
56Epstein-Barr virus infection_Homo sapiens_hsa051690.60686766
57Platelet activation_Homo sapiens_hsa046110.59873135
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59669995
59Olfactory transduction_Homo sapiens_hsa047400.56402009
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.54999657
61Serotonergic synapse_Homo sapiens_hsa047260.52304707
62Renin secretion_Homo sapiens_hsa049240.52042567
63Oxytocin signaling pathway_Homo sapiens_hsa049210.49871291
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49286261
65Pertussis_Homo sapiens_hsa051330.48592854
66Malaria_Homo sapiens_hsa051440.48185265
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47905707
68Salivary secretion_Homo sapiens_hsa049700.47629575
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46635420
70Systemic lupus erythematosus_Homo sapiens_hsa053220.46149159
71Dopaminergic synapse_Homo sapiens_hsa047280.46007786
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45719964
73Hepatitis C_Homo sapiens_hsa051600.45069778
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44289653
75Collecting duct acid secretion_Homo sapiens_hsa049660.44036297
76Lysosome_Homo sapiens_hsa041420.43542384
77Acute myeloid leukemia_Homo sapiens_hsa052210.43373303
78Shigellosis_Homo sapiens_hsa051310.42247253
79Hepatitis B_Homo sapiens_hsa051610.41302259
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41059026
81TNF signaling pathway_Homo sapiens_hsa046680.40611248
82MAPK signaling pathway_Homo sapiens_hsa040100.39578513
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39010257
84Prolactin signaling pathway_Homo sapiens_hsa049170.37401110
85Cholinergic synapse_Homo sapiens_hsa047250.37274077
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37088192
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.36789275
88Calcium signaling pathway_Homo sapiens_hsa040200.35731141
89Ether lipid metabolism_Homo sapiens_hsa005650.35719490
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35481472
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.35110766
92Propanoate metabolism_Homo sapiens_hsa006400.34701917
93cAMP signaling pathway_Homo sapiens_hsa040240.34249245
94Inositol phosphate metabolism_Homo sapiens_hsa005620.33187655
95Choline metabolism in cancer_Homo sapiens_hsa052310.32903931
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32897486
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.32520144
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32476597
99mTOR signaling pathway_Homo sapiens_hsa041500.31991294
100Insulin secretion_Homo sapiens_hsa049110.31771898

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