ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.49692571
2	DNA double-strand break processing (GO:0000729)	4.45373393
3	L-fucose catabolic process (GO:0042355)	3.85213786
4	fucose catabolic process (GO:0019317)	3.85213786
5	L-fucose metabolic process (GO:0042354)	3.85213786
6	neural tube formation (GO:0001841)	3.75055762
7	indolalkylamine metabolic process (GO:0006586)	3.57319269
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56667675
9	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.51184154
10	indole-containing compound catabolic process (GO:0042436)	3.50985687
11	indolalkylamine catabolic process (GO:0046218)	3.50985687
12	tryptophan catabolic process (GO:0006569)	3.50985687
13	response to pheromone (GO:0019236)	3.48276513
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40613754
15	kynurenine metabolic process (GO:0070189)	3.38176262
16	replication fork processing (GO:0031297)	3.37215426
17	rRNA catabolic process (GO:0016075)	3.33309235
18	centriole replication (GO:0007099)	3.28323574
19	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.28268169
20	regulation of translation, ncRNA-mediated (GO:0045974)	3.28268169
21	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.28268169
22	piRNA metabolic process (GO:0034587)	3.21541163
23	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.21537799
24	recombinational repair (GO:0000725)	3.17864115
25	double-strand break repair via homologous recombination (GO:0000724)	3.15287382
26	DNA deamination (GO:0045006)	3.09515852
27	epithelial cilium movement (GO:0003351)	3.07710230
28	regulation of DNA endoreduplication (GO:0032875)	3.07284028
29	reciprocal meiotic recombination (GO:0007131)	3.06428033
30	reciprocal DNA recombination (GO:0035825)	3.06428033
31	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05387653
32	protein K11-linked deubiquitination (GO:0035871)	3.05046155
33	tryptophan metabolic process (GO:0006568)	3.02258314
34	somite development (GO:0061053)	3.00208760
35	microtubule depolymerization (GO:0007019)	2.98711121
36	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.95013759
37	regulation of mitotic spindle checkpoint (GO:1903504)	2.95013759
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.93766714
39	axoneme assembly (GO:0035082)	2.93053707
40	synapsis (GO:0007129)	2.91000082
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.84564202
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.84564202
43	NADH dehydrogenase complex assembly (GO:0010257)	2.84564202
44	prenylation (GO:0097354)	2.84119143
45	protein prenylation (GO:0018342)	2.84119143
46	pyrimidine nucleobase catabolic process (GO:0006208)	2.82751793
47	nonmotile primary cilium assembly (GO:0035058)	2.82707387
48	cilium or flagellum-dependent cell motility (GO:0001539)	2.82519132
49	ncRNA catabolic process (GO:0034661)	2.81974446
50	meiotic chromosome segregation (GO:0045132)	2.78863749
51	respiratory chain complex IV assembly (GO:0008535)	2.74942285
52	detection of light stimulus involved in visual perception (GO:0050908)	2.74700984
53	detection of light stimulus involved in sensory perception (GO:0050962)	2.74700984
54	regulation of gene silencing by RNA (GO:0060966)	2.74654487
55	regulation of posttranscriptional gene silencing (GO:0060147)	2.74654487
56	regulation of gene silencing by miRNA (GO:0060964)	2.74654487
57	protein polyglutamylation (GO:0018095)	2.72344113
58	chromatin remodeling at centromere (GO:0031055)	2.71905640
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.71662904
60	negative regulation of telomere maintenance (GO:0032205)	2.67841557
61	cilium organization (GO:0044782)	2.67661727
62	DNA methylation involved in gamete generation (GO:0043046)	2.67144963
63	microtubule anchoring (GO:0034453)	2.66705891
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66468103
65	male meiosis I (GO:0007141)	2.66254273
66	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.65777420
67	male meiosis (GO:0007140)	2.65494712
68	platelet dense granule organization (GO:0060155)	2.65325011
69	cilium morphogenesis (GO:0060271)	2.65073252
70	photoreceptor cell maintenance (GO:0045494)	2.64153608
71	cilium movement (GO:0003341)	2.62999757
72	DNA replication checkpoint (GO:0000076)	2.62997359
73	regulation of mesoderm development (GO:2000380)	2.61543243
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.61310914
75	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.61310914
76	regulation of hippo signaling (GO:0035330)	2.60359741
77	regulation of meiosis I (GO:0060631)	2.60284254
78	intraciliary transport (GO:0042073)	2.60101137
79	protein complex biogenesis (GO:0070271)	2.59967229
80	cilium assembly (GO:0042384)	2.59142072
81	regulation of telomere maintenance (GO:0032204)	2.56145122
82	protein-cofactor linkage (GO:0018065)	2.55736373
83	retinal cone cell development (GO:0046549)	2.54744863
84	CENP-A containing nucleosome assembly (GO:0034080)	2.54736102
85	kidney morphogenesis (GO:0060993)	2.53845238
86	indole-containing compound metabolic process (GO:0042430)	2.53516636
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52221824
88	DNA demethylation (GO:0080111)	2.48905545
89	microtubule polymerization or depolymerization (GO:0031109)	2.48899637
90	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.48610837
91	neuron fate determination (GO:0048664)	2.48134644
92	resolution of meiotic recombination intermediates (GO:0000712)	2.48133681
93	photoreceptor cell development (GO:0042461)	2.46976927
94	atrial cardiac muscle cell action potential (GO:0086014)	2.46657003
95	regulation of centriole replication (GO:0046599)	2.46473384
96	head development (GO:0060322)	2.45760733
97	postreplication repair (GO:0006301)	2.44138847
98	negative regulation of mast cell activation (GO:0033004)	2.44112907
99	histone exchange (GO:0043486)	2.43386426
100	establishment of protein localization to Golgi (GO:0072600)	2.42586647

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.89092117
2	VDR_22108803_ChIP-Seq_LS180_Human	3.40285306
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87604819
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.82827669
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.76840593
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64056979
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.63474804
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61480094
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57214275
10	EWS_26573619_Chip-Seq_HEK293_Human	2.49917737
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47140149
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.45275975
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.32628221
14	FUS_26573619_Chip-Seq_HEK293_Human	2.29564184
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29004134
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18020178
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.15825980
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.15605332
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12148063
20	P300_19829295_ChIP-Seq_ESCs_Human	2.10512722
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.95594293
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.93922604
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.82553099
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78271670
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77318121
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.75440503
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74138655
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71913481
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.70796946
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65671490
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65282699
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62394679
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60782201
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.59709600
35	* STAT3_23295773_ChIP-Seq_U87_Human	1.55725536
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55491535
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55148905
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54952850
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54265448
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.54265448
41	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51493725
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47885703
43	* MYC_18940864_ChIP-ChIP_HL60_Human	1.46836457
44	* BCAT_22108803_ChIP-Seq_LS180_Human	1.45982724
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45348701
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.44663822
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43854774
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43600558
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43133708
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40779675
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39367500
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38027012
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38027012
54	TCF4_23295773_ChIP-Seq_U87_Human	1.37274347
55	* VDR_23849224_ChIP-Seq_CD4+_Human	1.37221397
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35576636
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35451599
58	AR_25329375_ChIP-Seq_VCAP_Human	1.34532051
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33372233
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32563510
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30975706
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27867425
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27024574
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26758932
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.25067736
66	* TCF4_22108803_ChIP-Seq_LS180_Human	1.23833524
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23485104
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23387712
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23387712
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22610489
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22097464
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21859219
73	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21268669
74	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.19830491
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16871617
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14397328
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13845252
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13495287
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12409343
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12160888
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09476464
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08679811
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07839754
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07627386
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07627386
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06962960
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04993908
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03959437
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03010677
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02025503
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00891545
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00203790
93	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99004203
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97334329
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96351628
96	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.95750473
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94595702
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91596834
99	AR_20517297_ChIP-Seq_VCAP_Human	0.91416411
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90931510

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.48674187
2	MP0008057_abnormal_DNA_replication	2.88698854
3	MP0000569_abnormal_digit_pigmentation	2.86226260
4	MP0002102_abnormal_ear_morphology	2.85948275
5	MP0003890_abnormal_embryonic-extraembry	2.50094382
6	MP0006292_abnormal_olfactory_placode	2.46722437
7	MP0008058_abnormal_DNA_repair	2.35982343
8	MP0005551_abnormal_eye_electrophysiolog	2.28342032
9	MP0003136_yellow_coat_color	2.22817885
10	MP0003787_abnormal_imprinting	2.18503658
11	MP0003195_calcinosis	2.16524949
12	MP0002736_abnormal_nociception_after	2.04906571
13	MP0001968_abnormal_touch/_nociception	1.98712822
14	MP0006072_abnormal_retinal_apoptosis	1.96148044
15	MP0005253_abnormal_eye_physiology	1.86309892
16	MP0003880_abnormal_central_pattern	1.75849206
17	MP0009046_muscle_twitch	1.73838658
18	MP0010094_abnormal_chromosome_stability	1.71630960
19	MP0006276_abnormal_autonomic_nervous	1.69453426
20	MP0001529_abnormal_vocalization	1.66725912
21	MP0003646_muscle_fatigue	1.62987466
22	MP0008872_abnormal_physiological_respon	1.60599793
23	MP0004142_abnormal_muscle_tone	1.60539581
24	MP0000427_abnormal_hair_cycle	1.60494522
25	MP0000631_abnormal_neuroendocrine_gland	1.60188773
26	MP0001986_abnormal_taste_sensitivity	1.58120474
27	MP0005646_abnormal_pituitary_gland	1.56207194
28	MP0002638_abnormal_pupillary_reflex	1.53155366
29	MP0002938_white_spotting	1.51651288
30	MP0009745_abnormal_behavioral_response	1.49771587
31	MP0003718_maternal_effect	1.43834709
32	MP0004133_heterotaxia	1.43583393
33	MP0002234_abnormal_pharynx_morphology	1.42389505
34	MP0005084_abnormal_gallbladder_morpholo	1.40511126
35	MP0001485_abnormal_pinna_reflex	1.37597599
36	MP0001984_abnormal_olfaction	1.34985071
37	MP0008875_abnormal_xenobiotic_pharmacok	1.32407747
38	MP0000372_irregular_coat_pigmentation	1.32276551
39	MP0004043_abnormal_pH_regulation	1.31918728
40	MP0008789_abnormal_olfactory_epithelium	1.30833684
41	MP0008995_early_reproductive_senescence	1.30726723
42	MP0002272_abnormal_nervous_system	1.29758200
43	MP0004885_abnormal_endolymph	1.28975990
44	MP0000778_abnormal_nervous_system	1.28362252
45	MP0001486_abnormal_startle_reflex	1.26788497
46	MP0005645_abnormal_hypothalamus_physiol	1.26068705
47	MP0005394_taste/olfaction_phenotype	1.24282085
48	MP0005499_abnormal_olfactory_system	1.24282085
49	MP0005174_abnormal_tail_pigmentation	1.23818899
50	MP0003693_abnormal_embryo_hatching	1.23655683
51	MP0003119_abnormal_digestive_system	1.22076789
52	MP0002735_abnormal_chemical_nociception	1.21751695
53	MP0002751_abnormal_autonomic_nervous	1.21664486
54	MP0002653_abnormal_ependyma_morphology	1.21529151
55	MP0005389_reproductive_system_phenotype	1.21307675
56	MP0003011_delayed_dark_adaptation	1.21100977
57	MP0001293_anophthalmia	1.18112249
58	MP0002210_abnormal_sex_determination	1.17336135
59	MP0003121_genomic_imprinting	1.17018087
60	MP0001929_abnormal_gametogenesis	1.16917928
61	MP0002160_abnormal_reproductive_system	1.15528935
62	MP0001188_hyperpigmentation	1.15393887
63	MP0002928_abnormal_bile_duct	1.14936348
64	MP0001919_abnormal_reproductive_system	1.12981577
65	MP0001501_abnormal_sleep_pattern	1.12804753
66	MP0003937_abnormal_limbs/digits/tail_de	1.10185689
67	MP0003698_abnormal_male_reproductive	1.09451223
68	MP0000383_abnormal_hair_follicle	1.08768842
69	MP0004147_increased_porphyrin_level	1.07709976
70	MP0004742_abnormal_vestibular_system	1.07586021
71	MP0002572_abnormal_emotion/affect_behav	1.06088208
72	MP0005386_behavior/neurological_phenoty	1.02813882
73	MP0004924_abnormal_behavior	1.02813882
74	MP0002557_abnormal_social/conspecific_i	1.02360636
75	MP0002837_dystrophic_cardiac_calcinosis	1.02309990
76	MP0002067_abnormal_sensory_capabilities	1.01703063
77	MP0003567_abnormal_fetal_cardiomyocyte	0.99557101
78	MP0005423_abnormal_somatic_nervous	0.98965431
79	MP0005195_abnormal_posterior_eye	0.98175572
80	MP0000653_abnormal_sex_gland	0.97350030
81	MP0001145_abnormal_male_reproductive	0.97059548
82	MP0005391_vision/eye_phenotype	0.95056069
83	MP0001324_abnormal_eye_pigmentation	0.93009943
84	MP0000647_abnormal_sebaceous_gland	0.91891362
85	MP0002752_abnormal_somatic_nervous	0.90566132
86	MP0005075_abnormal_melanosome_morpholog	0.89833601
87	MP0002095_abnormal_skin_pigmentation	0.89641432
88	MP0002064_seizures	0.83759939
89	MP0000049_abnormal_middle_ear	0.83753834
90	MP0001764_abnormal_homeostasis	0.83037714
91	MP0002163_abnormal_gland_morphology	0.82724427
92	MP0002184_abnormal_innervation	0.81786532
93	MP0003137_abnormal_impulse_conducting	0.81277471
94	MP0004215_abnormal_myocardial_fiber	0.81194134
95	MP0003635_abnormal_synaptic_transmissio	0.80116446
96	MP0002063_abnormal_learning/memory/cond	0.79403123
97	MP0005187_abnormal_penis_morphology	0.79112005
98	MP0002876_abnormal_thyroid_physiology	0.79071896
99	MP0001970_abnormal_pain_threshold	0.78481909
100	MP0004145_abnormal_muscle_electrophysio	0.78417324

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08221252
2	True hermaphroditism (HP:0010459)	3.79266076
3	Abnormality of midbrain morphology (HP:0002418)	3.56681209
4	Molar tooth sign on MRI (HP:0002419)	3.56681209
5	Pancreatic fibrosis (HP:0100732)	3.49843075
6	Congenital stationary night blindness (HP:0007642)	3.35871415
7	Nephronophthisis (HP:0000090)	3.22495139
8	Abnormality of the labia minora (HP:0012880)	3.19273157
9	Chronic hepatic failure (HP:0100626)	2.94591531
10	Hyperventilation (HP:0002883)	2.89708399
11	Abnormality of the renal medulla (HP:0100957)	2.83775387
12	Birth length less than 3rd percentile (HP:0003561)	2.74206812
13	Medial flaring of the eyebrow (HP:0010747)	2.73691912
14	Abnormality of the renal cortex (HP:0011035)	2.72616804
15	Attenuation of retinal blood vessels (HP:0007843)	2.56534608
16	Abolished electroretinogram (ERG) (HP:0000550)	2.52830008
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.50250314
18	Abnormality of alanine metabolism (HP:0010916)	2.50250314
19	Hyperalaninemia (HP:0003348)	2.50250314
20	Colon cancer (HP:0003003)	2.47029824
21	Type II lissencephaly (HP:0007260)	2.43393631
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42253938
23	Progressive inability to walk (HP:0002505)	2.37411897
24	Inability to walk (HP:0002540)	2.36874973
25	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.33677543
26	Pendular nystagmus (HP:0012043)	2.31520974
27	Patellar aplasia (HP:0006443)	2.31065700
28	Protruding tongue (HP:0010808)	2.28874755
29	Lissencephaly (HP:0001339)	2.27944488
30	Cystic liver disease (HP:0006706)	2.26923287
31	Gait imbalance (HP:0002141)	2.26234787
32	Gaze-evoked nystagmus (HP:0000640)	2.25586080
33	Stomach cancer (HP:0012126)	2.25247752
34	Absent/shortened dynein arms (HP:0200106)	2.23324341
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.23324341
36	Volvulus (HP:0002580)	2.20625620
37	Congenital primary aphakia (HP:0007707)	2.20071144
38	Abnormality of the ileum (HP:0001549)	2.18998543
39	Renal cortical cysts (HP:0000803)	2.18169929
40	Abnormality of the pons (HP:0007361)	2.18110986
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17683356
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.15537376
43	Genetic anticipation (HP:0003743)	2.14875033
44	Progressive cerebellar ataxia (HP:0002073)	2.13966301
45	Meckel diverticulum (HP:0002245)	2.13928143
46	Nephrogenic diabetes insipidus (HP:0009806)	2.13611604
47	Hypoplasia of the pons (HP:0012110)	2.10573312
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06660260
49	Broad-based gait (HP:0002136)	2.04931650
50	Male pseudohermaphroditism (HP:0000037)	2.03612416
51	Sclerocornea (HP:0000647)	2.03206547
52	Anencephaly (HP:0002323)	2.02531003
53	Genital tract atresia (HP:0001827)	2.00039790
54	Intestinal atresia (HP:0011100)	1.99595731
55	Small hand (HP:0200055)	1.98795480
56	Oligodactyly (hands) (HP:0001180)	1.97006167
57	Abnormal drinking behavior (HP:0030082)	1.96597428
58	Polydipsia (HP:0001959)	1.96597428
59	Abnormality of chromosome stability (HP:0003220)	1.96437733
60	Bile duct proliferation (HP:0001408)	1.95142439
61	Abnormal biliary tract physiology (HP:0012439)	1.95142439
62	Febrile seizures (HP:0002373)	1.93094339
63	Vaginal atresia (HP:0000148)	1.92789099
64	Sloping forehead (HP:0000340)	1.90340394
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.89936755
66	Optic nerve hypoplasia (HP:0000609)	1.88646521
67	Abnormal respiratory epithelium morphology (HP:0012253)	1.88501020
68	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88501020
69	Methylmalonic acidemia (HP:0002912)	1.87109190
70	Tubular atrophy (HP:0000092)	1.86912252
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86688545
72	Short tibia (HP:0005736)	1.85807793
73	Postaxial foot polydactyly (HP:0001830)	1.85699561
74	Ectopic kidney (HP:0000086)	1.85400183
75	Chorioretinal atrophy (HP:0000533)	1.83333286
76	Retinal dysplasia (HP:0007973)	1.81934760
77	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81034030
78	Cerebellar dysplasia (HP:0007033)	1.80728282
79	Hyperglycinemia (HP:0002154)	1.80395193
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80232459
81	Fair hair (HP:0002286)	1.79725322
82	Abnormal ciliary motility (HP:0012262)	1.79093038
83	Chromsome breakage (HP:0040012)	1.78213212
84	Dandy-Walker malformation (HP:0001305)	1.77608240
85	Atonic seizures (HP:0010819)	1.76005406
86	Hyperglycinuria (HP:0003108)	1.75621611
87	Poor coordination (HP:0002370)	1.75175794
88	3-Methylglutaconic aciduria (HP:0003535)	1.75044325
89	Large for gestational age (HP:0001520)	1.74594703
90	Congenital hepatic fibrosis (HP:0002612)	1.74325033
91	Tubulointerstitial nephritis (HP:0001970)	1.73523039
92	Hypothermia (HP:0002045)	1.72889136
93	Postaxial hand polydactyly (HP:0001162)	1.72509246
94	Supernumerary spleens (HP:0009799)	1.70821345
95	Preaxial hand polydactyly (HP:0001177)	1.68762029
96	Furrowed tongue (HP:0000221)	1.67679552
97	Pachygyria (HP:0001302)	1.66507694
98	Astigmatism (HP:0000483)	1.66285604
99	Aplasia/hypoplasia of the uterus (HP:0008684)	1.66024601
100	Increased corneal curvature (HP:0100692)	1.65945627

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.00751182
2	ACVR1B	2.94943593
3	WNK3	2.91785659
4	ZAK	2.69545275
5	BMPR1B	2.65555379
6	NUAK1	2.51614543
7	MAP4K2	2.36791115
8	PINK1	2.29043543
9	CASK	2.28339296
10	ADRBK2	2.25834173
11	MKNK2	2.13971227
12	BRSK2	1.93402540
13	TRIM28	1.91660109
14	GRK1	1.82147494
15	INSRR	1.80914106
16	TNIK	1.79834324
17	MAP3K4	1.68916685
18	MAPK13	1.68102184
19	TAOK3	1.63589637
20	WNK4	1.58871721
21	WEE1	1.55696802
22	PLK4	1.54055116
23	TLK1	1.50802743
24	ERBB3	1.36771080
25	MKNK1	1.36200870
26	PNCK	1.31683720
27	STK16	1.25249130
28	CAMKK2	1.23217241
29	CDC7	1.22305031
30	VRK1	1.20881998
31	DYRK2	1.19226989
32	OXSR1	1.19212842
33	SRPK1	1.17842475
34	BCR	1.16157657
35	STK39	1.13119858
36	PLK3	1.11729058
37	MARK1	1.05829176
38	TSSK6	1.03741314
39	PAK3	1.01032606
40	EIF2AK3	0.99327235
41	TXK	0.98646705
42	BUB1	0.91967211
43	PLK2	0.90603070
44	EPHA4	0.88150949
45	CSNK1G2	0.87333831
46	TGFBR1	0.86652819
47	CSNK1G1	0.86561519
48	MAP2K7	0.85029882
49	STK38L	0.82487290
50	NLK	0.80969830
51	NEK2	0.80855721
52	DAPK2	0.79653298
53	TEC	0.77697631
54	PLK1	0.76090973
55	BRD4	0.76036964
56	CSNK1A1L	0.74702953
57	PRKCG	0.74485338
58	PRKCE	0.74131995
59	DYRK3	0.73026170
60	CSNK1G3	0.72320878
61	ATR	0.72143023
62	BCKDK	0.70726855
63	NTRK3	0.68743249
64	ADRBK1	0.68346125
65	AKT3	0.66532461
66	PIK3CA	0.65609680
67	RPS6KA5	0.64866660
68	CCNB1	0.62060376
69	CHEK2	0.61678932
70	FGFR2	0.57458992
71	SGK2	0.56242278
72	STK3	0.56041443
73	MAPK15	0.55611457
74	MST4	0.55394857
75	ATM	0.54303944
76	NTRK2	0.53958732
77	NEK1	0.48899227
78	RPS6KA4	0.47146892
79	PRKCQ	0.44693944
80	IRAK1	0.43034691
81	PKN1	0.42631176
82	CSNK1A1	0.42177945
83	CSNK1D	0.40504163
84	CAMK2A	0.39748616
85	CDK3	0.38310977
86	CDK19	0.36691478
87	TTK	0.36629760
88	DYRK1A	0.35975743
89	MUSK	0.35883256
90	LATS1	0.35281738
91	EIF2AK2	0.33353876
92	SGK494	0.32611480
93	SGK223	0.32611480
94	CAMK1	0.32577135
95	PRKACA	0.32299986
96	BRSK1	0.32283815
97	TIE1	0.32195153
98	PASK	0.31398327
99	ITK	0.30114643
100	MAPKAPK5	0.29713653

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.83394356
2	Phototransduction_Homo sapiens_hsa04744	2.64972500
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.62650512
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.33544495
5	Basal transcription factors_Homo sapiens_hsa03022	2.32577865
6	Nicotine addiction_Homo sapiens_hsa05033	2.26373688
7	Butanoate metabolism_Homo sapiens_hsa00650	2.20700791
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17159323
9	Protein export_Homo sapiens_hsa03060	2.10928381
10	RNA polymerase_Homo sapiens_hsa03020	2.08896016
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.05808573
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05291051
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.04094438
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03178107
15	RNA degradation_Homo sapiens_hsa03018	1.95714588
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95081719
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.94756514
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.89693785
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85425513
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84120953
21	Caffeine metabolism_Homo sapiens_hsa00232	1.80080666
22	Propanoate metabolism_Homo sapiens_hsa00640	1.77665054
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77654812
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74622335
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.59103893
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.55969920
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.50911729
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.47717455
29	Mismatch repair_Homo sapiens_hsa03430	1.42549304
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39752364
31	One carbon pool by folate_Homo sapiens_hsa00670	1.38660466
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36525824
33	Taste transduction_Homo sapiens_hsa04742	1.35264178
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29718289
35	RNA transport_Homo sapiens_hsa03013	1.29577739
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28333737
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24752275
38	Olfactory transduction_Homo sapiens_hsa04740	1.19922395
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.19876895
40	Peroxisome_Homo sapiens_hsa04146	1.19104837
41	Regulation of autophagy_Homo sapiens_hsa04140	1.16145035
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14328670
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11278713
44	ABC transporters_Homo sapiens_hsa02010	1.04566847
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.02088125
46	Morphine addiction_Homo sapiens_hsa05032	1.01177557
47	Parkinsons disease_Homo sapiens_hsa05012	0.96339623
48	DNA replication_Homo sapiens_hsa03030	0.95774377
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95635287
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91734444
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90932100
52	Retinol metabolism_Homo sapiens_hsa00830	0.88485479
53	Serotonergic synapse_Homo sapiens_hsa04726	0.84454550
54	Huntingtons disease_Homo sapiens_hsa05016	0.83084068
55	Purine metabolism_Homo sapiens_hsa00230	0.82519378
56	GABAergic synapse_Homo sapiens_hsa04727	0.81615929
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.78789199
58	Base excision repair_Homo sapiens_hsa03410	0.78634910
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77522733
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76686220
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75643199
62	Cell cycle_Homo sapiens_hsa04110	0.72096694
63	Circadian entrainment_Homo sapiens_hsa04713	0.72017850
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.71568776
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.70070970
66	Proteasome_Homo sapiens_hsa03050	0.69660038
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69547270
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68751844
69	Spliceosome_Homo sapiens_hsa03040	0.67509321
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66990262
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66923022
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65177983
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63342296
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63106363
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60089098
76	Lysine degradation_Homo sapiens_hsa00310	0.58851192
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58581371
78	Circadian rhythm_Homo sapiens_hsa04710	0.58302475
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57034387
80	p53 signaling pathway_Homo sapiens_hsa04115	0.56282135
81	Metabolic pathways_Homo sapiens_hsa01100	0.55744212
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54468899
83	Insulin secretion_Homo sapiens_hsa04911	0.48394807
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.46703387
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46263127
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.46136985
87	Oocyte meiosis_Homo sapiens_hsa04114	0.44921464
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44786102
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43202491
90	Salivary secretion_Homo sapiens_hsa04970	0.43094057
91	Alcoholism_Homo sapiens_hsa05034	0.41589271
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.40237146
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40217364
94	Alzheimers disease_Homo sapiens_hsa05010	0.39938279
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39686977
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39519500
97	Amphetamine addiction_Homo sapiens_hsa05031	0.37434853
98	Histidine metabolism_Homo sapiens_hsa00340	0.37278792
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35305558
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34613687

ZNF675

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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