ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.18667892
2	presynaptic membrane assembly (GO:0097105)	4.17510436
3	behavioral response to nicotine (GO:0035095)	4.16340497
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.91048417
5	presynaptic membrane organization (GO:0097090)	3.87609546
6	nonmotile primary cilium assembly (GO:0035058)	3.80290353
7	response to pheromone (GO:0019236)	3.60030629
8	epithelial cilium movement (GO:0003351)	3.58925692
9	nucleobase catabolic process (GO:0046113)	3.40490969
10	somite development (GO:0061053)	3.26615105
11	postsynaptic membrane organization (GO:0001941)	3.18395626
12	neuron fate determination (GO:0048664)	3.15962675
13	behavioral response to ethanol (GO:0048149)	3.14790558
14	neuron cell-cell adhesion (GO:0007158)	3.14081355
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12271700
16	protein polyglutamylation (GO:0018095)	3.08921067
17	intraciliary transport (GO:0042073)	3.07063797
18	cilium morphogenesis (GO:0060271)	3.04473138
19	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.02738387
20	auditory behavior (GO:0031223)	3.01868930
21	gamma-aminobutyric acid transport (GO:0015812)	3.00343382
22	regulation of cilium movement (GO:0003352)	2.97688965
23	centriole replication (GO:0007099)	2.97643346
24	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.93924396
25	cilium organization (GO:0044782)	2.93559262
26	cilium assembly (GO:0042384)	2.91124335
27	retinal ganglion cell axon guidance (GO:0031290)	2.89864278
28	forebrain neuron differentiation (GO:0021879)	2.89847983
29	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.87944046
30	cilium movement (GO:0003341)	2.87922380
31	protein localization to cilium (GO:0061512)	2.81898321
32	regulation of timing of cell differentiation (GO:0048505)	2.81648005
33	limb bud formation (GO:0060174)	2.79888312
34	regulation of development, heterochronic (GO:0040034)	2.79837733
35	neural tube formation (GO:0001841)	2.77777865
36	platelet dense granule organization (GO:0060155)	2.73794155
37	mechanosensory behavior (GO:0007638)	2.73776804
38	regulation of meiosis I (GO:0060631)	2.72432174
39	retinal cone cell development (GO:0046549)	2.70743717
40	cilium or flagellum-dependent cell motility (GO:0001539)	2.68634684
41	resolution of meiotic recombination intermediates (GO:0000712)	2.68297597
42	transmission of nerve impulse (GO:0019226)	2.67608455
43	kidney morphogenesis (GO:0060993)	2.67088341
44	protein-cofactor linkage (GO:0018065)	2.63081225
45	axonal fasciculation (GO:0007413)	2.62491941
46	axoneme assembly (GO:0035082)	2.61731354
47	photoreceptor cell maintenance (GO:0045494)	2.61380491
48	otic vesicle formation (GO:0030916)	2.60402158
49	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.60295880
50	olfactory bulb development (GO:0021772)	2.59157424
51	DNA double-strand break processing (GO:0000729)	2.59043328
52	negative regulation of telomere maintenance (GO:0032205)	2.54949197
53	L-fucose catabolic process (GO:0042355)	2.54581066
54	fucose catabolic process (GO:0019317)	2.54581066
55	L-fucose metabolic process (GO:0042354)	2.54581066
56	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.54252992
57	regulation of collateral sprouting (GO:0048670)	2.53933680
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.51359929
59	NADH dehydrogenase complex assembly (GO:0010257)	2.51359929
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.51359929
61	protein localization to synapse (GO:0035418)	2.50911567
62	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.50506695
63	hindbrain development (GO:0030902)	2.50286419
64	piRNA metabolic process (GO:0034587)	2.49898227
65	positive regulation of mitochondrial fission (GO:0090141)	2.48230946
66	vocalization behavior (GO:0071625)	2.47456731
67	appendage development (GO:0048736)	2.47322040
68	limb development (GO:0060173)	2.47322040
69	head development (GO:0060322)	2.46611357
70	cell proliferation in forebrain (GO:0021846)	2.46557462
71	regulation of telomere maintenance (GO:0032204)	2.45321429
72	regulation of neurotransmitter uptake (GO:0051580)	2.45283675
73	protein complex biogenesis (GO:0070271)	2.44205122
74	neuronal stem cell maintenance (GO:0097150)	2.43664074
75	smoothened signaling pathway (GO:0007224)	2.43488423
76	substrate-independent telencephalic tangential migration (GO:0021826)	2.43310033
77	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.43310033
78	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.42508375
79	water-soluble vitamin biosynthetic process (GO:0042364)	2.41143328
80	photoreceptor cell development (GO:0042461)	2.41029207
81	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40291170
82	reflex (GO:0060004)	2.40209780
83	spinal cord motor neuron differentiation (GO:0021522)	2.39227615
84	nephron tubule morphogenesis (GO:0072078)	2.39079788
85	nephron epithelium morphogenesis (GO:0072088)	2.39079788
86	synapse assembly (GO:0007416)	2.39003985
87	negative regulation of glial cell differentiation (GO:0045686)	2.38788896
88	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.38562300
89	regulation of translation, ncRNA-mediated (GO:0045974)	2.38562300
90	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.38562300
91	somite rostral/caudal axis specification (GO:0032525)	2.38043260
92	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.37632391
93	detection of light stimulus involved in visual perception (GO:0050908)	2.36731243
94	detection of light stimulus involved in sensory perception (GO:0050962)	2.36731243
95	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.35379154
96	synapsis (GO:0007129)	2.35189127
97	cornea development in camera-type eye (GO:0061303)	2.34209381
98	replication fork processing (GO:0031297)	2.33989632
99	single strand break repair (GO:0000012)	2.33285994
100	neuronal action potential (GO:0019228)	2.32947461

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.06894348
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.46234668
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.03241275
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88530939
5	VDR_22108803_ChIP-Seq_LS180_Human	2.70078606
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63837640
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63250589
8	FUS_26573619_Chip-Seq_HEK293_Human	2.51908560
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50831372
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44387200
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38194043
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.31852691
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.31136780
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29874547
15	EWS_26573619_Chip-Seq_HEK293_Human	2.26284513
16	P300_19829295_ChIP-Seq_ESCs_Human	2.23936197
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.23694573
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17749881
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.13704271
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99175839
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93644378
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84681068
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84364131
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82849294
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.81636263
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68565903
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67173470
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64814926
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.64413547
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63355766
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61806904
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.60859120
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60859120
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57634992
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.56440763
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53991670
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53470884
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52531653
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51742787
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51509514
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.50767903
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50767903
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50211899
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49636534
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48482371
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48276385
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46148323
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45232713
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44867665
50	* AR_25329375_ChIP-Seq_VCAP_Human	1.43654093
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.41280170
52	STAT3_23295773_ChIP-Seq_U87_Human	1.38926821
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38529369
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.37058668
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.36614001
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35150449
57	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.35121416
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34994535
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31959395
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31080656
61	TCF4_23295773_ChIP-Seq_U87_Human	1.28795187
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28710175
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.28293665
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28117011
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24251041
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.23862872
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23555665
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23555665
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22702945
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20594181
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.18833936
72	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18449821
73	* TCF4_22108803_ChIP-Seq_LS180_Human	1.17734352
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15996391
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15894455
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12252833
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12060224
78	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11921890
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.11876141
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11329801
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11002964
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09883261
83	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09261998
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06964981
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05726809
86	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04548854
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03522731
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02417641
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01770076
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.01294395
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00675281
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00443841
93	JUN_21703547_ChIP-Seq_K562_Human	0.97830065
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97003599
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96950914
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96690090
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96560048
98	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.96281730
99	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96268483
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95056797

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.04913416
2	MP0008877_abnormal_DNA_methylation	2.79270114
3	MP0006292_abnormal_olfactory_placode	2.74920875
4	MP0003880_abnormal_central_pattern	2.55410009
5	MP0001529_abnormal_vocalization	2.44437138
6	MP0002102_abnormal_ear_morphology	2.37554606
7	MP0003787_abnormal_imprinting	2.33714821
8	MP0002653_abnormal_ependyma_morphology	2.31953342
9	MP0002822_catalepsy	2.28837042
10	MP0001984_abnormal_olfaction	2.05389538
11	MP0006072_abnormal_retinal_apoptosis	2.00566931
12	MP0008789_abnormal_olfactory_epithelium	1.98505593
13	MP0000778_abnormal_nervous_system	1.97881564
14	MP0006276_abnormal_autonomic_nervous	1.95898160
15	MP0002736_abnormal_nociception_after	1.93962916
16	MP0001968_abnormal_touch/_nociception	1.91414794
17	MP0005551_abnormal_eye_electrophysiolog	1.90226961
18	MP0003121_genomic_imprinting	1.80028569
19	MP0005394_taste/olfaction_phenotype	1.79857199
20	MP0005499_abnormal_olfactory_system	1.79857199
21	MP0003122_maternal_imprinting	1.77640362
22	MP0004133_heterotaxia	1.74806218
23	MP0002938_white_spotting	1.73200398
24	MP0000569_abnormal_digit_pigmentation	1.72285756
25	MP0002638_abnormal_pupillary_reflex	1.71224304
26	MP0001188_hyperpigmentation	1.70177753
27	MP0005646_abnormal_pituitary_gland	1.65279461
28	MP0001293_anophthalmia	1.63939311
29	MP0000631_abnormal_neuroendocrine_gland	1.63713299
30	MP0003890_abnormal_embryonic-extraembry	1.62161007
31	MP0003195_calcinosis	1.62018925
32	MP0001486_abnormal_startle_reflex	1.59813326
33	MP0005253_abnormal_eye_physiology	1.58838815
34	MP0004142_abnormal_muscle_tone	1.57595208
35	MP0005423_abnormal_somatic_nervous	1.54066051
36	MP0009745_abnormal_behavioral_response	1.53555092
37	MP0002272_abnormal_nervous_system	1.52649182
38	MP0002234_abnormal_pharynx_morphology	1.50203750
39	MP0005645_abnormal_hypothalamus_physiol	1.47615988
40	MP0002735_abnormal_chemical_nociception	1.45133187
41	MP0002751_abnormal_autonomic_nervous	1.45068163
42	MP0004885_abnormal_endolymph	1.40904374
43	MP0001986_abnormal_taste_sensitivity	1.40576976
44	MP0001485_abnormal_pinna_reflex	1.40445681
45	MP0003718_maternal_effect	1.39293001
46	MP0008995_early_reproductive_senescence	1.39177097
47	MP0008058_abnormal_DNA_repair	1.36509454
48	MP0005084_abnormal_gallbladder_morpholo	1.35957626
49	MP0003011_delayed_dark_adaptation	1.33502574
50	MP0002572_abnormal_emotion/affect_behav	1.32279539
51	MP0000049_abnormal_middle_ear	1.32092305
52	MP0009046_muscle_twitch	1.31616499
53	MP0002557_abnormal_social/conspecific_i	1.30571323
54	MP0002734_abnormal_mechanical_nocicepti	1.29123004
55	MP0003635_abnormal_synaptic_transmissio	1.27384750
56	MP0002837_dystrophic_cardiac_calcinosis	1.26226139
57	MP0005187_abnormal_penis_morphology	1.24590351
58	MP0003119_abnormal_digestive_system	1.21825432
59	MP0000566_synostosis	1.19093795
60	MP0003937_abnormal_limbs/digits/tail_de	1.16554921
61	MP0002752_abnormal_somatic_nervous	1.13672041
62	MP0002063_abnormal_learning/memory/cond	1.13355804
63	MP0000026_abnormal_inner_ear	1.12213582
64	MP0004147_increased_porphyrin_level	1.12051470
65	MP0002067_abnormal_sensory_capabilities	1.11843957
66	MP0000955_abnormal_spinal_cord	1.11353396
67	MP0005195_abnormal_posterior_eye	1.10064201
68	MP0003567_abnormal_fetal_cardiomyocyte	1.08510658
69	MP0000427_abnormal_hair_cycle	1.07430536
70	MP0001970_abnormal_pain_threshold	1.06365101
71	MP0002184_abnormal_innervation	1.05100377
72	MP0002064_seizures	1.03932925
73	MP0002928_abnormal_bile_duct	1.03612016
74	MP0002233_abnormal_nose_morphology	1.02651745
75	MP0004859_abnormal_synaptic_plasticity	1.02367208
76	MP0002733_abnormal_thermal_nociception	1.01642605
77	MP0004270_analgesia	1.01081595
78	MP0000647_abnormal_sebaceous_gland	1.00713614
79	MP0004924_abnormal_behavior	1.00438369
80	MP0005386_behavior/neurological_phenoty	1.00438369
81	MP0001286_abnormal_eye_development	1.00309821
82	MP0005367_renal/urinary_system_phenotyp	0.98906915
83	MP0000516_abnormal_urinary_system	0.98906915
84	MP0000372_irregular_coat_pigmentation	0.98567152
85	MP0002882_abnormal_neuron_morphology	0.97537701
86	MP0003698_abnormal_male_reproductive	0.94705173
87	MP0005391_vision/eye_phenotype	0.94603726
88	MP0004215_abnormal_myocardial_fiber	0.92643657
89	MP0003938_abnormal_ear_development	0.90651346
90	MP0001929_abnormal_gametogenesis	0.90535913
91	MP0002210_abnormal_sex_determination	0.88533259
92	MP0004742_abnormal_vestibular_system	0.88445569
93	MP0003861_abnormal_nervous_system	0.87381251
94	MP0001963_abnormal_hearing_physiology	0.86531389
95	MP0001324_abnormal_eye_pigmentation	0.86099097
96	MP0005410_abnormal_fertilization	0.85954893
97	MP0004145_abnormal_muscle_electrophysio	0.82329687
98	MP0009379_abnormal_foot_pigmentation	0.82197728
99	MP0001501_abnormal_sleep_pattern	0.81548727
100	MP0002152_abnormal_brain_morphology	0.81057925

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.16716458
2	Pancreatic fibrosis (HP:0100732)	4.10103012
3	True hermaphroditism (HP:0010459)	4.01269517
4	Molar tooth sign on MRI (HP:0002419)	3.86231768
5	Abnormality of midbrain morphology (HP:0002418)	3.86231768
6	Abnormality of the labia minora (HP:0012880)	3.69849081
7	Nephronophthisis (HP:0000090)	3.64384599
8	Medial flaring of the eyebrow (HP:0010747)	3.47191850
9	Gait imbalance (HP:0002141)	3.14520579
10	Abnormality of the renal medulla (HP:0100957)	3.03011366
11	Congenital primary aphakia (HP:0007707)	2.99078384
12	Septo-optic dysplasia (HP:0100842)	2.88244746
13	Chronic hepatic failure (HP:0100626)	2.79612380
14	Nephrogenic diabetes insipidus (HP:0009806)	2.75045557
15	Hyperventilation (HP:0002883)	2.73470130
16	Genital tract atresia (HP:0001827)	2.72087233
17	Sclerocornea (HP:0000647)	2.70227437
18	Cystic liver disease (HP:0006706)	2.67455206
19	Vaginal atresia (HP:0000148)	2.66346859
20	Optic nerve hypoplasia (HP:0000609)	2.65374615
21	Type II lissencephaly (HP:0007260)	2.60640985
22	Anencephaly (HP:0002323)	2.56569057
23	Colon cancer (HP:0003003)	2.49419933
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.44817726
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42406431
26	Abnormality of the renal cortex (HP:0011035)	2.39292205
27	Congenital stationary night blindness (HP:0007642)	2.38159907
28	Lissencephaly (HP:0001339)	2.34991639
29	Intestinal atresia (HP:0011100)	2.24237314
30	Absent/shortened dynein arms (HP:0200106)	2.24100627
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24100627
32	Retinal dysplasia (HP:0007973)	2.23470086
33	Hyperglycinemia (HP:0002154)	2.22004053
34	Occipital encephalocele (HP:0002085)	2.19482858
35	Postaxial hand polydactyly (HP:0001162)	2.17870526
36	Poor coordination (HP:0002370)	2.15814499
37	Congenital hepatic fibrosis (HP:0002612)	2.14996689
38	Pendular nystagmus (HP:0012043)	2.14112214
39	Tubular atrophy (HP:0000092)	2.13701827
40	Oligodactyly (hands) (HP:0001180)	2.13399908
41	Supernumerary spleens (HP:0009799)	2.12223847
42	Progressive cerebellar ataxia (HP:0002073)	2.11502679
43	Postaxial foot polydactyly (HP:0001830)	2.09903465
44	Specific learning disability (HP:0001328)	2.09836349
45	Polyphagia (HP:0002591)	2.07019392
46	Preaxial hand polydactyly (HP:0001177)	2.06563397
47	Polydipsia (HP:0001959)	2.04720702
48	Abnormal drinking behavior (HP:0030082)	2.04720702
49	Pachygyria (HP:0001302)	2.03696092
50	Abolished electroretinogram (ERG) (HP:0000550)	2.03399842
51	Hemiparesis (HP:0001269)	2.03380715
52	Male pseudohermaphroditism (HP:0000037)	2.02724829
53	Narrow forehead (HP:0000341)	2.00994995
54	Gastrointestinal atresia (HP:0002589)	1.99264449
55	Anophthalmia (HP:0000528)	1.98001617
56	Limb dystonia (HP:0002451)	1.97673042
57	Attenuation of retinal blood vessels (HP:0007843)	1.96608491
58	Inability to walk (HP:0002540)	1.95528487
59	Bile duct proliferation (HP:0001408)	1.94862692
60	Abnormal biliary tract physiology (HP:0012439)	1.94862692
61	Drooling (HP:0002307)	1.94103840
62	Acute necrotizing encephalopathy (HP:0006965)	1.93308089
63	Broad-based gait (HP:0002136)	1.92632121
64	Broad foot (HP:0001769)	1.92339532
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91434626
66	Hyperglycinuria (HP:0003108)	1.87923389
67	Cerebellar dysplasia (HP:0007033)	1.87279826
68	Absent septum pellucidum (HP:0001331)	1.87157460
69	Abnormal respiratory epithelium morphology (HP:0012253)	1.86416449
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86416449
71	Bilateral microphthalmos (HP:0007633)	1.85941773
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84789770
73	Esophageal atresia (HP:0002032)	1.83842119
74	Patellar aplasia (HP:0006443)	1.83826430
75	Genetic anticipation (HP:0003743)	1.83302210
76	Renal cortical cysts (HP:0000803)	1.82735492
77	Dandy-Walker malformation (HP:0001305)	1.80541791
78	Abnormal ciliary motility (HP:0012262)	1.80322031
79	Febrile seizures (HP:0002373)	1.78945783
80	Focal motor seizures (HP:0011153)	1.77280581
81	Methylmalonic acidemia (HP:0002912)	1.76681630
82	Rib fusion (HP:0000902)	1.76235537
83	Keratoconus (HP:0000563)	1.75356747
84	Increased corneal curvature (HP:0100692)	1.75356747
85	Hypothermia (HP:0002045)	1.74988333
86	Volvulus (HP:0002580)	1.74394666
87	Labial hypoplasia (HP:0000066)	1.73187866
88	Mitochondrial inheritance (HP:0001427)	1.73133950
89	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72541777
90	Abnormality of glycine metabolism (HP:0010895)	1.72541777
91	Furrowed tongue (HP:0000221)	1.72426081
92	Atonic seizures (HP:0010819)	1.72359965
93	Progressive macrocephaly (HP:0004481)	1.71613963
94	Absent speech (HP:0001344)	1.71245065
95	Micropenis (HP:0000054)	1.70680266
96	Gaze-evoked nystagmus (HP:0000640)	1.70058844
97	Acute encephalopathy (HP:0006846)	1.70004076
98	Aganglionic megacolon (HP:0002251)	1.69525721
99	Tubulointerstitial nephritis (HP:0001970)	1.68882939
100	Excessive salivation (HP:0003781)	1.68564113

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.40612848
2	CASK	3.06043270
3	WNK3	2.96823669
4	BMPR1B	2.70233620
5	MAP4K2	2.68888881
6	MARK1	2.44503261
7	PNCK	2.40148010
8	TNIK	2.32590811
9	MAPK13	2.30841820
10	MAP3K4	2.02352585
11	DYRK2	1.90959720
12	TRIM28	1.89714854
13	ADRBK2	1.88474626
14	NUAK1	1.86361254
15	ZAK	1.84106174
16	MKNK2	1.63700000
17	BCR	1.62732273
18	INSRR	1.56566403
19	NTRK2	1.54208269
20	GRK1	1.54103702
21	PINK1	1.52805382
22	WNK4	1.49793015
23	PAK3	1.34805931
24	PLK2	1.31797356
25	MAP2K7	1.31591161
26	WEE1	1.29472157
27	STK38L	1.28810731
28	PLK4	1.25086696
29	EPHA4	1.21894553
30	MKNK1	1.21438288
31	CSNK1G2	1.20250497
32	PRKCG	1.18237245
33	VRK1	1.16643557
34	MAPK15	1.16092859
35	BCKDK	1.15812298
36	ACVR1B	1.14115202
37	STK39	1.11521199
38	CSNK1G1	1.10932407
39	NTRK3	1.10660844
40	TAOK3	1.09862711
41	OXSR1	1.08939751
42	SRPK1	1.04946754
43	TGFBR1	1.04544113
44	DYRK3	1.03924361
45	FGFR2	1.03365287
46	PLK3	1.01663116
47	PRKCE	1.00911969
48	CSNK1G3	1.00199094
49	TLK1	1.00109311
50	CDK19	0.90790939
51	ERBB3	0.90044719
52	BRSK2	0.87678138
53	CSNK1A1L	0.85062242
54	TIE1	0.82223446
55	PKN1	0.81649874
56	EPHB2	0.80213196
57	CDC7	0.78388720
58	TSSK6	0.75244294
59	MINK1	0.70845004
60	EPHA3	0.67080538
61	DYRK1A	0.66001163
62	PHKG1	0.65249268
63	PHKG2	0.65249268
64	ADRBK1	0.64649951
65	PLK1	0.63574740
66	STK16	0.61950095
67	CAMK2A	0.61804306
68	FLT3	0.61014763
69	DAPK2	0.59973064
70	SGK223	0.58469917
71	SGK494	0.58469917
72	UHMK1	0.55624969
73	CDK3	0.53684152
74	SGK2	0.51338136
75	OBSCN	0.51297084
76	STK3	0.50054706
77	PRKACA	0.48779651
78	BUB1	0.48690972
79	TXK	0.44677375
80	ATM	0.43992633
81	PRKG1	0.43956843
82	VRK2	0.43126510
83	CSNK1D	0.42602303
84	AKT3	0.41748923
85	PRKD3	0.41261944
86	EIF2AK3	0.39128880
87	NME1	0.38554910
88	CSNK1A1	0.38400166
89	RPS6KA5	0.38324351
90	CAMK1	0.38138292
91	CAMK1G	0.37790044
92	CAMKK2	0.37466152
93	NEK2	0.37408115
94	PRKACB	0.36526306
95	PRKCZ	0.36395054
96	ATR	0.36289464
97	CSNK1E	0.35426954
98	CDK5	0.35041640
99	IRAK1	0.34878464
100	DYRK1B	0.33072537

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.78124213
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76518458
3	Protein export_Homo sapiens_hsa03060	2.75919053
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58139980
5	Phototransduction_Homo sapiens_hsa04744	2.55848330
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26850438
7	Parkinsons disease_Homo sapiens_hsa05012	2.22393810
8	Basal transcription factors_Homo sapiens_hsa03022	2.15536386
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05491287
10	Propanoate metabolism_Homo sapiens_hsa00640	1.98554900
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98097190
12	Butanoate metabolism_Homo sapiens_hsa00650	1.90139713
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84237292
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81868763
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.79181733
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.73945891
17	Homologous recombination_Homo sapiens_hsa03440	1.72604076
18	Taste transduction_Homo sapiens_hsa04742	1.70829378
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65470711
20	RNA polymerase_Homo sapiens_hsa03020	1.64773373
21	Huntingtons disease_Homo sapiens_hsa05016	1.64185718
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62906362
23	RNA degradation_Homo sapiens_hsa03018	1.61134702
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60472874
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.58597538
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54988146
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51194904
28	GABAergic synapse_Homo sapiens_hsa04727	1.48621192
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.48210270
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.47738334
31	Morphine addiction_Homo sapiens_hsa05032	1.42295111
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.41806493
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.33429200
34	Olfactory transduction_Homo sapiens_hsa04740	1.31327147
35	Circadian entrainment_Homo sapiens_hsa04713	1.28895907
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27486894
37	Alzheimers disease_Homo sapiens_hsa05010	1.25489928
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.21907779
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.19885854
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.14132263
41	Basal cell carcinoma_Homo sapiens_hsa05217	1.06941936
42	Fatty acid elongation_Homo sapiens_hsa00062	1.03221553
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02359974
44	Regulation of autophagy_Homo sapiens_hsa04140	1.02130187
45	Tryptophan metabolism_Homo sapiens_hsa00380	1.01454808
46	Serotonergic synapse_Homo sapiens_hsa04726	0.99936891
47	Ribosome_Homo sapiens_hsa03010	0.98568968
48	Insulin secretion_Homo sapiens_hsa04911	0.97995902
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.97728729
50	Peroxisome_Homo sapiens_hsa04146	0.96646612
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96021463
52	Cocaine addiction_Homo sapiens_hsa05030	0.94954626
53	Caffeine metabolism_Homo sapiens_hsa00232	0.90497244
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86640836
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79011258
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77903318
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.76989794
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75287771
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75081059
60	RNA transport_Homo sapiens_hsa03013	0.73652936
61	Axon guidance_Homo sapiens_hsa04360	0.73409023
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73305428
63	Retinol metabolism_Homo sapiens_hsa00830	0.73285162
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.72071896
65	Purine metabolism_Homo sapiens_hsa00230	0.71239893
66	Oocyte meiosis_Homo sapiens_hsa04114	0.70474363
67	Amphetamine addiction_Homo sapiens_hsa05031	0.70469300
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70274597
69	Mismatch repair_Homo sapiens_hsa03430	0.70082789
70	Circadian rhythm_Homo sapiens_hsa04710	0.69546653
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69531278
72	Long-term depression_Homo sapiens_hsa04730	0.68435519
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65281536
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64764593
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64309318
76	Salivary secretion_Homo sapiens_hsa04970	0.63652586
77	Spliceosome_Homo sapiens_hsa03040	0.63161110
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62994739
79	Proteasome_Homo sapiens_hsa03050	0.62767596
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61245507
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59309439
82	Metabolic pathways_Homo sapiens_hsa01100	0.58179448
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56626986
84	One carbon pool by folate_Homo sapiens_hsa00670	0.56534516
85	Base excision repair_Homo sapiens_hsa03410	0.53695660
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.52942216
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51751748
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49584172
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.49388616
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48341271
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47824534
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47404665
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47369845
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.46277862
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46183810
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44248082
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.43091093
98	Cholinergic synapse_Homo sapiens_hsa04725	0.43005846
99	p53 signaling pathway_Homo sapiens_hsa04115	0.36654342
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35756513

ZNF677

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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