ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	7.23936362
2	meiosis I (GO:0007127)	6.20277957
3	multicellular organism reproduction (GO:0032504)	4.65305138
4	male meiosis (GO:0007140)	4.28530780
5	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.23072562
6	regulation of acrosome reaction (GO:0060046)	4.17959030
7	histone H3-K9 demethylation (GO:0033169)	4.12527249
8	mitotic metaphase plate congression (GO:0007080)	4.06382678
9	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	36.4479760
10	regulation of retinoic acid receptor signaling pathway (GO:0048385)	30.5416953
11	regulation of DNA methylation (GO:0044030)	3.99149333
12	positive regulation of protein homooligomerization (GO:0032464)	3.75108106
13	transcription from mitochondrial promoter (GO:0006390)	3.68027597
14	chromosome condensation (GO:0030261)	3.67488050
15	rRNA modification (GO:0000154)	3.65890612
16	binding of sperm to zona pellucida (GO:0007339)	3.45664339
17	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.40446229
18	mitotic chromosome condensation (GO:0007076)	3.39500622
19	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.38761270
20	reproduction (GO:0000003)	3.37438513
21	regulation of exit from mitosis (GO:0007096)	3.26493835
22	chaperone-mediated protein transport (GO:0072321)	3.26448973
23	meiotic nuclear division (GO:0007126)	3.25451511
24	DNA packaging (GO:0006323)	3.24244015
25	rRNA methylation (GO:0031167)	3.17318069
26	metaphase plate congression (GO:0051310)	3.16472336
27	ribosome assembly (GO:0042255)	3.08506510
28	acrosome reaction (GO:0007340)	3.08301888
29	spermatid nucleus differentiation (GO:0007289)	3.07045463
30	regulation of histone H3-K9 methylation (GO:0051570)	3.07022850
31	regulation of female receptivity (GO:0045924)	3.05219459
32	oocyte development (GO:0048599)	3.03881632
33	meiotic cell cycle (GO:0051321)	3.03857386
34	regulation of female gonad development (GO:2000194)	2.98068580
35	meiotic cell cycle process (GO:1903046)	2.97606688
36	sperm-egg recognition (GO:0035036)	2.96134602
37	piRNA metabolic process (GO:0034587)	2.95603133
38	autophagic vacuole assembly (GO:0000045)	2.95333625
39	aggressive behavior (GO:0002118)	2.93852590
40	N-terminal protein amino acid acetylation (GO:0006474)	2.85433674
41	ventricular cardiac muscle cell development (GO:0055015)	2.84311049
42	regulation of spindle organization (GO:0090224)	2.82367336
43	maturation of SSU-rRNA (GO:0030490)	2.79850111
44	attachment of spindle microtubules to kinetochore (GO:0008608)	2.79582306
45	histone exchange (GO:0043486)	2.73494908
46	CENP-A containing nucleosome assembly (GO:0034080)	2.72756999
47	protein localization to chromosome, centromeric region (GO:0071459)	2.72380099
48	fusion of sperm to egg plasma membrane (GO:0007342)	2.71540994
49	polyamine biosynthetic process (GO:0006596)	2.68906704
50	drinking behavior (GO:0042756)	2.68339715
51	hyperosmotic salinity response (GO:0042538)	2.66823507
52	protein K6-linked ubiquitination (GO:0085020)	2.66726560
53	single fertilization (GO:0007338)	2.65713604
54	retinal cone cell development (GO:0046549)	2.65650513
55	snRNA transcription (GO:0009301)	2.65018232
56	single strand break repair (GO:0000012)	2.62044868
57	female mating behavior (GO:0060180)	2.60827824
58	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.60277830
59	microtubule polymerization or depolymerization (GO:0031109)	2.59432768
60	positive regulation of catecholamine secretion (GO:0033605)	2.59204784
61	regulation of mitotic spindle organization (GO:0060236)	2.58472393
62	regulation of uterine smooth muscle contraction (GO:0070472)	2.55657667
63	positive regulation of histone H3-K4 methylation (GO:0051571)	2.53889691
64	kinetochore assembly (GO:0051382)	2.53784553
65	positive regulation of gastrulation (GO:2000543)	2.52936457
66	sleep (GO:0030431)	2.50669243
67	regulation of G0 to G1 transition (GO:0070316)	2.48129269
68	primitive streak formation (GO:0090009)	2.46773618
69	chromatin remodeling at centromere (GO:0031055)	2.46392632
70	negative regulation of reproductive process (GO:2000242)	2.45969484
71	positive regulation of prostaglandin secretion (GO:0032308)	2.45512149
72	regulation of penile erection (GO:0060405)	2.44857973
73	histone mRNA metabolic process (GO:0008334)	2.44407450
74	gamete generation (GO:0007276)	2.42375201
75	regulation of helicase activity (GO:0051095)	2.41130030
76	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.41005556
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.40608913
78	termination of RNA polymerase III transcription (GO:0006386)	2.40608913
79	DNA replication checkpoint (GO:0000076)	2.38254957
80	synaptonemal complex organization (GO:0070193)	2.38051995
81	microtubule depolymerization (GO:0007019)	2.37235494
82	cell-cell recognition (GO:0009988)	2.37177497
83	response to acidic pH (GO:0010447)	2.35497907
84	spermatogenesis (GO:0007283)	2.35227982
85	male gamete generation (GO:0048232)	2.34450281
86	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.30575186
87	spermatid development (GO:0007286)	2.30402303
88	telomere maintenance via telomere lengthening (GO:0010833)	2.28925642
89	positive regulation of meiotic cell cycle (GO:0051446)	2.28720728
90	oocyte maturation (GO:0001556)	2.28056050
91	positive regulation of chromosome segregation (GO:0051984)	2.27863921
92	DNA methylation involved in gamete generation (GO:0043046)	2.27660754
93	fertilization (GO:0009566)	2.27337984
94	positive regulation of digestive system process (GO:0060456)	2.26827741
95	regulation of cell cycle G2/M phase transition (GO:1902749)	2.24320186
96	cellular response to pH (GO:0071467)	2.24269268
97	establishment of chromosome localization (GO:0051303)	2.24208597
98	centriole replication (GO:0007099)	2.23331344
99	regulation of meiosis I (GO:0060631)	2.22254944
100	nuclear pore complex assembly (GO:0051292)	2.20765253

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.95956966
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.90995957
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.81470838
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.74679578
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.17300176
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.17300176
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.17300176
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.91366359
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.83607013
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.56378501
11	E2F7_22180533_ChIP-Seq_HELA_Human	3.56235207
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.32445631
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.16504003
14	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00600205
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91745805
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.80906249
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.59258346
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.49101147
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.45028655
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.31656737
21	ETV1_20927104_ChIP-Seq_GIST48_Human	2.27536492
22	RBPJ_21746931_ChIP-Seq_IB4_Human	2.18924357
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.13707793
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11157467
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.07827645
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07483751
27	TBL1_22424771_ChIP-Seq_293T_Human	1.95494282
28	NFYB_21822215_ChIP-Seq_K562_Human	1.91022692
29	PHF8_20622853_ChIP-Seq_HELA_Human	1.88772375
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.82791915
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.80461370
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.75651447
33	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.67813129
34	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.67286917
35	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.64791594
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.57605664
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.53673755
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.51497949
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41499639
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.40885810
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38880483
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.35636793
43	NFYA_21822215_ChIP-Seq_K562_Human	1.31244083
44	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.30644925
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26974952
46	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.26616058
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24218663
48	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.21446544
49	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.20402796
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19774925
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17073996
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14113824
53	RAC3_21632823_ChIP-Seq_H3396_Human	1.13972564
54	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.12115778
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11973046
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09967771
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06040641
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04831772
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04508572
60	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.03065687
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02076393
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.01593576
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00431048
64	NCOR_22424771_ChIP-Seq_293T_Human	0.99807964
65	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.99773906
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99338834
67	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98647808
68	VDR_22108803_ChIP-Seq_LS180_Human	0.98086993
69	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97249837
70	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96676540
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95836866
72	TAF15_26573619_Chip-Seq_HEK293_Human	0.95397582
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95050077
74	XRN2_22483619_ChIP-Seq_HELA_Human	0.93970506
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.92813724
76	GABP_19822575_ChIP-Seq_HepG2_Human	0.91998116
77	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.89041572
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88554577
79	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.85590410
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.84080895
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.82574154
82	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81600938
83	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81534365
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.81165768
85	CTCF_20526341_ChIP-Seq_ESCs_Human	0.80485043
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.80091750
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.79906190
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.79795780
89	KDM5A_27292631_Chip-Seq_BREAST_Human	0.79391905
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.78227261
91	IGF1R_20145208_ChIP-Seq_DFB_Human	0.76225204
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.75116531
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.74435201
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.72113524
95	GATA3_26560356_Chip-Seq_TH1_Human	0.71071893
96	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.69991962
97	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.69991962
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.69677129
99	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.69520655
100	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.68813056

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.00458627
2	MP0005423_abnormal_somatic_nervous	5.07856719
3	MP0001986_abnormal_taste_sensitivity	4.97655627
4	MP0003718_maternal_effect	4.42220005
5	MP0005410_abnormal_fertilization	3.72356109
6	MP0009379_abnormal_foot_pigmentation	3.47662575
7	MP0003693_abnormal_embryo_hatching	3.05450453
8	MP0005394_taste/olfaction_phenotype	2.92296404
9	MP0005499_abnormal_olfactory_system	2.92296404
10	MP0003136_yellow_coat_color	2.76727114
11	MP0001929_abnormal_gametogenesis	2.63853154
12	MP0002127_abnormal_cardiovascular_syste	2.40989088
13	MP0008877_abnormal_DNA_methylation	2.39580495
14	MP0010307_abnormal_tumor_latency	2.39352619
15	MP0004957_abnormal_blastocyst_morpholog	2.30630470
16	MP0010030_abnormal_orbit_morphology	2.30623898
17	MP0002160_abnormal_reproductive_system	2.25369165
18	MP0003077_abnormal_cell_cycle	2.18015689
19	MP0002210_abnormal_sex_determination	2.15324062
20	MP0008789_abnormal_olfactory_epithelium	2.15316058
21	MP0010094_abnormal_chromosome_stability	2.12148588
22	MP0008058_abnormal_DNA_repair	2.11659067
23	MP0003111_abnormal_nucleus_morphology	2.06851533
24	MP0000372_irregular_coat_pigmentation	1.96730413
25	MP0002277_abnormal_respiratory_mucosa	1.92624488
26	MP0008057_abnormal_DNA_replication	1.92209018
27	MP0003698_abnormal_male_reproductive	1.92117730
28	MP0002161_abnormal_fertility/fecundity	1.62090224
29	MP0002234_abnormal_pharynx_morphology	1.61307257
30	MP0005395_other_phenotype	1.56554823
31	MP0000653_abnormal_sex_gland	1.49863348
32	MP0003646_muscle_fatigue	1.48062037
33	MP0001293_anophthalmia	1.47230482
34	MP0005389_reproductive_system_phenotype	1.45807178
35	MP0003890_abnormal_embryonic-extraembry	1.40730285
36	MP0003699_abnormal_female_reproductive	1.39440669
37	MP0001145_abnormal_male_reproductive	1.36952564
38	MP0000049_abnormal_middle_ear	1.31009507
39	MP0003121_genomic_imprinting	1.30244778
40	MP0006276_abnormal_autonomic_nervous	1.27410757
41	MP0002138_abnormal_hepatobiliary_system	1.27191307
42	MP0001881_abnormal_mammary_gland	1.23197167
43	MP0009333_abnormal_splenocyte_physiolog	1.22432903
44	MP0001672_abnormal_embryogenesis/_devel	1.16030361
45	MP0005380_embryogenesis_phenotype	1.16030361
46	MP0005647_abnormal_sex_gland	1.11535154
47	MP0008932_abnormal_embryonic_tissue	1.11342432
48	MP0008995_early_reproductive_senescence	1.03421088
49	MP0009840_abnormal_foam_cell	1.01989474
50	MP0001730_embryonic_growth_arrest	1.01906190
51	MP0008260_abnormal_autophagy	1.01765605
52	MP0003879_abnormal_hair_cell	0.99581230
53	MP0003119_abnormal_digestive_system	0.97798370
54	MP0003938_abnormal_ear_development	0.95806052
55	MP0005646_abnormal_pituitary_gland	0.95211426
56	MP0000678_abnormal_parathyroid_gland	0.91944064
57	MP0001502_abnormal_circadian_rhythm	0.88101393
58	MP0002751_abnormal_autonomic_nervous	0.87858397
59	MP0002233_abnormal_nose_morphology	0.87610035
60	MP0001666_abnormal_nutrient_absorption	0.87017467
61	MP0000350_abnormal_cell_proliferation	0.86964811
62	MP0003984_embryonic_growth_retardation	0.86119812
63	MP0001119_abnormal_female_reproductive	0.85209033
64	MP0002254_reproductive_system_inflammat	0.82890613
65	MP0002088_abnormal_embryonic_growth/wei	0.81767877
66	MP0003936_abnormal_reproductive_system	0.80591860
67	MP0005551_abnormal_eye_electrophysiolog	0.79412584
68	MP0003950_abnormal_plasma_membrane	0.78647569
69	MP0006036_abnormal_mitochondrial_physio	0.78305826
70	MP0001286_abnormal_eye_development	0.76635780
71	MP0001697_abnormal_embryo_size	0.75429435
72	MP0010368_abnormal_lymphatic_system	0.74094349
73	MP0002102_abnormal_ear_morphology	0.72773068
74	MP0000762_abnormal_tongue_morphology	0.70008029
75	MP0000631_abnormal_neuroendocrine_gland	0.69552046
76	MP0002085_abnormal_embryonic_tissue	0.68798927
77	MP0003755_abnormal_palate_morphology	0.68278597
78	MP0004215_abnormal_myocardial_fiber	0.67729903
79	MP0005360_urolithiasis	0.67675647
80	MP0002084_abnormal_developmental_patter	0.65968901
81	MP0001968_abnormal_touch/_nociception	0.65651516
82	MP0000428_abnormal_craniofacial_morphol	0.64842398
83	MP0002163_abnormal_gland_morphology	0.64278812
84	MP0004381_abnormal_hair_follicle	0.63130625
85	MP0005379_endocrine/exocrine_gland_phen	0.62503826
86	MP0002653_abnormal_ependyma_morphology	0.62114246
87	MP0001485_abnormal_pinna_reflex	0.61410589
88	MP0002697_abnormal_eye_size	0.58881982
89	MP0003880_abnormal_central_pattern	0.56499027
90	MP0002080_prenatal_lethality	0.54590702
91	MP0004019_abnormal_vitamin_homeostasis	0.53706694
92	MP0000627_abnormal_mammary_gland	0.52986940
93	MP0004142_abnormal_muscle_tone	0.50440046
94	MP0003195_calcinosis	0.50277312
95	MP0002873_normal_phenotype	0.50262908
96	MP0002169_no_abnormal_phenotype	0.50164295
97	MP0003567_abnormal_fetal_cardiomyocyte	0.48520686
98	MP0000358_abnormal_cell_content/	0.48331355
99	MP0001919_abnormal_reproductive_system	0.48210908
100	MP0005197_abnormal_uvea_morphology	0.47396346

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	6.81129469
2	Double outlet right ventricle (HP:0001719)	4.14011536
3	Congenital malformation of the right heart (HP:0011723)	4.14011536
4	Premature ovarian failure (HP:0008209)	3.96593317
5	Short tibia (HP:0005736)	3.84173718
6	Abnormality of abdominal situs (HP:0011620)	3.75179004
7	Abdominal situs inversus (HP:0003363)	3.75179004
8	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.63260748
9	Abnormality of the septum pellucidum (HP:0007375)	3.60706954
10	Septo-optic dysplasia (HP:0100842)	3.60565866
11	Posterior subcapsular cataract (HP:0007787)	3.51600958
12	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.49980452
13	Impulsivity (HP:0100710)	3.39102949
14	Patent foramen ovale (HP:0001655)	3.35261519
15	Carpal bone hypoplasia (HP:0001498)	3.30996801
16	Absent septum pellucidum (HP:0001331)	3.21865615
17	Abnormal pancreas size (HP:0012094)	3.21463091
18	Abnormal umbilical cord blood vessels (HP:0011403)	3.16556865
19	Single umbilical artery (HP:0001195)	3.16556865
20	Abnormality of the fetal cardiovascular system (HP:0010948)	3.16556865
21	Attenuation of retinal blood vessels (HP:0007843)	3.14283632
22	Rhinitis (HP:0012384)	3.13288499
23	Malnutrition (HP:0004395)	3.12999567
24	Hypophosphatemic rickets (HP:0004912)	3.11529267
25	Aplasia/hypoplasia of the uterus (HP:0008684)	3.09830076
26	Infertility (HP:0000789)	3.09380819
27	Preauricular pit (HP:0004467)	3.04179058
28	Periauricular skin pits (HP:0100277)	3.04179058
29	Abnormal ciliary motility (HP:0012262)	2.97745032
30	Birth length less than 3rd percentile (HP:0003561)	2.90507217
31	Meckel diverticulum (HP:0002245)	2.82179407
32	Abnormality of the preputium (HP:0100587)	2.74762817
33	Abnormality of the ileum (HP:0001549)	2.72956589
34	Subcapsular cataract (HP:0000523)	2.72316124
35	Facial cleft (HP:0002006)	2.69420280
36	Chromsome breakage (HP:0040012)	2.64222679
37	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.63570612
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.62550265
39	Absent/shortened dynein arms (HP:0200106)	2.62550265
40	Midline defect of the nose (HP:0004122)	2.61936001
41	Constricted visual fields (HP:0001133)	2.61418830
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.60298528
43	Aplasia/hypoplasia of the humerus (HP:0006507)	2.57833596
44	Abnormality of the aortic arch (HP:0012303)	2.56250088
45	Reticulocytopenia (HP:0001896)	2.56018707
46	Myokymia (HP:0002411)	2.55077280
47	Azoospermia (HP:0000027)	2.53439626
48	Hypercortisolism (HP:0001578)	2.53315656
49	Bony spicule pigmentary retinopathy (HP:0007737)	2.51347248
50	Median cleft lip (HP:0000161)	2.50841420
51	Abnormal respiratory motile cilium physiology (HP:0012261)	2.49209070
52	Osteomalacia (HP:0002749)	2.46148114
53	Abnormal spermatogenesis (HP:0008669)	2.42922176
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.41041807
55	Microretrognathia (HP:0000308)	2.38484467
56	Maternal diabetes (HP:0009800)	2.36151635
57	Ureteral duplication (HP:0000073)	2.35955055
58	Severe visual impairment (HP:0001141)	2.33781981
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33020165
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31740572
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.31740572
62	Hypoplasia of the uterus (HP:0000013)	2.30503633
63	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.29105821
64	Abnormal number of incisors (HP:0011064)	2.23622263
65	Absent radius (HP:0003974)	2.23221030
66	Hypoglycemic seizures (HP:0002173)	2.23217854
67	Supernumerary spleens (HP:0009799)	2.21108883
68	Absent thumb (HP:0009777)	2.20425140
69	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.19308741
70	Sensory axonal neuropathy (HP:0003390)	2.17319015
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16085913
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14257695
73	Abnormality of chromosome stability (HP:0003220)	2.12699129
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12102935
75	Skin pits (HP:0100276)	2.11021892
76	Glycosuria (HP:0003076)	2.10233208
77	Abnormality of urine glucose concentration (HP:0011016)	2.10233208
78	Optic nerve hypoplasia (HP:0000609)	2.09199618
79	Absent forearm bone (HP:0003953)	2.08902630
80	Aplasia involving forearm bones (HP:0009822)	2.08902630
81	Horseshoe kidney (HP:0000085)	2.06327175
82	Progressive sensorineural hearing impairment (HP:0000408)	2.01780442
83	Hypoplasia of the fovea (HP:0007750)	1.98184744
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.98184744
85	Fused cervical vertebrae (HP:0002949)	1.97507192
86	Glossoptosis (HP:0000162)	1.93360225
87	Stenosis of the external auditory canal (HP:0000402)	1.90455253
88	Tetraparesis (HP:0002273)	1.90002922
89	Cleft eyelid (HP:0000625)	1.89835404
90	Pendular nystagmus (HP:0012043)	1.86610357
91	Cortical visual impairment (HP:0100704)	1.85462480
92	Concave nail (HP:0001598)	1.84962399
93	Pancreatic cysts (HP:0001737)	1.79279849
94	Limb dystonia (HP:0002451)	1.78946703
95	Progressive hearing impairment (HP:0001730)	1.78775069
96	Retinal atrophy (HP:0001105)	1.78389439
97	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.77261556
98	Dysphonia (HP:0001618)	1.76961603
99	Abnormality of the umbilical cord (HP:0010881)	1.75438100
100	Decreased central vision (HP:0007663)	1.75426918

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	4.53667954
2	SRPK1	4.22232264
3	LATS2	3.90983871
4	TESK2	3.56259426
5	PLK4	3.47468711
6	STK16	3.44113792
7	TRIM28	3.20006729
8	CDK19	2.73841346
9	NEK6	2.31441721
10	PLK1	2.28322355
11	DYRK3	2.26834873
12	BRSK1	1.95796281
13	TTK	1.90694748
14	TAOK3	1.89196991
15	AURKA	1.80798884
16	CDC7	1.78494678
17	PLK3	1.77320208
18	CDK9	1.72035293
19	MAP3K9	1.70364506
20	TNIK	1.69002688
21	AURKB	1.66980860
22	ZAK	1.64793639
23	WNK1	1.59951874
24	CDK12	1.52944318
25	CDK7	1.42144417
26	BRSK2	1.42015023
27	NEK2	1.39951381
28	WNK3	1.38041553
29	TESK1	1.33509901
30	PBK	1.27052693
31	PDK2	1.25796050
32	MARK3	1.23665183
33	CHEK1	1.22302591
34	INSRR	1.17888440
35	VRK1	1.09110827
36	CSNK1E	1.03444695
37	BRD4	1.02206636
38	TLK1	0.98988336
39	PIM2	0.98975165
40	BMPR1B	0.95148111
41	CHEK2	0.94077669
42	ATR	0.89437801
43	ACVR1B	0.89096992
44	PRKCI	0.87077875
45	CDK2	0.86753060
46	GSK3A	0.86273036
47	MAP4K2	0.82368598
48	NUAK1	0.82037772
49	PKN1	0.81132366
50	PIM1	0.80254721
51	CSNK2A1	0.79105986
52	CDK1	0.78085944
53	MELK	0.77260965
54	CSNK2A2	0.74634820
55	ATM	0.72252441
56	WEE1	0.71487214
57	RAF1	0.71075278
58	EIF2AK3	0.70271889
59	PLK2	0.66871069
60	MAPK13	0.66450744
61	BRAF	0.61887684
62	CDK3	0.59592383
63	STK3	0.57354614
64	PRKG1	0.57208330
65	DDR2	0.55597797
66	PAK2	0.54450368
67	MTOR	0.54426955
68	PRKACB	0.53705434
69	STK4	0.53394180
70	STK39	0.51673667
71	LRRK2	0.50348365
72	MAP3K8	0.49175068
73	GSK3B	0.47990145
74	MAP3K5	0.44880097
75	PAK1	0.44344360
76	MAPK1	0.43603322
77	TSSK6	0.39760424
78	TEC	0.38893184
79	RPS6KA1	0.38816371
80	GRK1	0.38794936
81	MAPK14	0.34397359
82	CSNK1D	0.33396834
83	STK38L	0.32792716
84	CDK11A	0.31921959
85	PRKACA	0.29831757
86	MAP3K4	0.29435089
87	PRKCE	0.27783587
88	AKT2	0.27453849
89	KDR	0.27201352
90	PRKCG	0.26759060
91	DYRK1A	0.26690425
92	STK10	0.26240641
93	EPHB2	0.25877479
94	PRKD1	0.25754560
95	CSNK1A1	0.25110849
96	IRAK2	0.25098932
97	NME1	0.24213878
98	TIE1	0.20805900
99	TBK1	0.20329547
100	CAMK1	0.19759277

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.35523174
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.18477897
3	Regulation of autophagy_Homo sapiens_hsa04140	3.50108797
4	Ribosome_Homo sapiens_hsa03010	3.47216053
5	RNA polymerase_Homo sapiens_hsa03020	3.32352561
6	mRNA surveillance pathway_Homo sapiens_hsa03015	3.27034938
7	RNA transport_Homo sapiens_hsa03013	3.17831814
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.82560915
9	Spliceosome_Homo sapiens_hsa03040	2.66817023
10	Cell cycle_Homo sapiens_hsa04110	2.65423644
11	Oocyte meiosis_Homo sapiens_hsa04114	2.45204801
12	Folate biosynthesis_Homo sapiens_hsa00790	2.40485499
13	Homologous recombination_Homo sapiens_hsa03440	2.36044815
14	p53 signaling pathway_Homo sapiens_hsa04115	2.25404241
15	Mismatch repair_Homo sapiens_hsa03430	2.21885509
16	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.05984098
17	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05083440
18	Taste transduction_Homo sapiens_hsa04742	1.85789525
19	RNA degradation_Homo sapiens_hsa03018	1.76081563
20	Caffeine metabolism_Homo sapiens_hsa00232	1.66671588
21	Huntingtons disease_Homo sapiens_hsa05016	1.47407054
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.39143053
23	Base excision repair_Homo sapiens_hsa03410	1.37270863
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33317708
25	Olfactory transduction_Homo sapiens_hsa04740	1.30881472
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27972670
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25743083
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24248059
29	DNA replication_Homo sapiens_hsa03030	1.22224719
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19276918
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.17852244
32	Purine metabolism_Homo sapiens_hsa00230	1.17723539
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.12673128
34	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.12145797
35	Sulfur metabolism_Homo sapiens_hsa00920	1.11515158
36	Fatty acid elongation_Homo sapiens_hsa00062	1.00735230
37	Parkinsons disease_Homo sapiens_hsa05012	1.00169212
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.96796984
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89276556
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.83465676
41	Viral carcinogenesis_Homo sapiens_hsa05203	0.82792722
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80744813
43	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80369175
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.78060636
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.76499316
46	Protein export_Homo sapiens_hsa03060	0.75747607
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75243398
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.72594180
49	Insulin secretion_Homo sapiens_hsa04911	0.71735901
50	Nicotine addiction_Homo sapiens_hsa05033	0.66744924
51	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.64853072
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61518822
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.61396983
54	MicroRNAs in cancer_Homo sapiens_hsa05206	0.56201877
55	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.55137260
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.55050988
57	Herpes simplex infection_Homo sapiens_hsa05168	0.54821106
58	Proteasome_Homo sapiens_hsa03050	0.52450112
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.52423579
60	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51840667
61	Alcoholism_Homo sapiens_hsa05034	0.48985193
62	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44926325
63	Serotonergic synapse_Homo sapiens_hsa04726	0.42944331
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42772490
65	Bile secretion_Homo sapiens_hsa04976	0.39530664
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37905797
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37806044
68	GABAergic synapse_Homo sapiens_hsa04727	0.36822849
69	Glutathione metabolism_Homo sapiens_hsa00480	0.36813654
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32499771
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.32166571
72	Retinol metabolism_Homo sapiens_hsa00830	0.31192640
73	Metabolic pathways_Homo sapiens_hsa01100	0.30939446
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.29976392
75	Amphetamine addiction_Homo sapiens_hsa05031	0.29513107
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.28287080
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.27485624
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.27159414
79	Phototransduction_Homo sapiens_hsa04744	0.26943733
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25788043
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24989394
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24253787
83	Mineral absorption_Homo sapiens_hsa04978	0.23130064
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.23065701
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.22778705
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.18934058
87	Morphine addiction_Homo sapiens_hsa05032	0.18443781
88	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.17712155
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.15411668
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.13944852
91	Hepatitis B_Homo sapiens_hsa05161	0.13635931
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.13561043
93	Small cell lung cancer_Homo sapiens_hsa05222	0.10227533
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.09273874
95	ABC transporters_Homo sapiens_hsa02010	0.08291298
96	Circadian entrainment_Homo sapiens_hsa04713	0.07190635
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.06715056
98	Alzheimers disease_Homo sapiens_hsa05010	0.06362752
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.06221505
100	Legionellosis_Homo sapiens_hsa05134	0.05039018

ZNF679

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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