ZNF681

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.09780088
2DNA double-strand break processing (GO:0000729)4.00264156
3chromatin remodeling at centromere (GO:0031055)3.74790623
4regulation of nuclear cell cycle DNA replication (GO:0033262)3.68592749
5negative regulation of DNA-dependent DNA replication (GO:2000104)3.66590014
6CENP-A containing nucleosome assembly (GO:0034080)3.49429057
7regulation of mitotic spindle checkpoint (GO:1903504)3.40719873
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40719873
9replication fork processing (GO:0031297)3.38661410
10behavioral response to nicotine (GO:0035095)3.37147412
11synapsis (GO:0007129)3.33352114
12respiratory chain complex IV assembly (GO:0008535)3.28003944
13centriole replication (GO:0007099)3.23283007
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22656156
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18702959
16double-strand break repair via homologous recombination (GO:0000724)3.16672755
17regulation of meiosis I (GO:0060631)3.15946440
18recombinational repair (GO:0000725)3.15689528
19water-soluble vitamin biosynthetic process (GO:0042364)3.15390928
20histone exchange (GO:0043486)3.15164095
21DNA replication checkpoint (GO:0000076)3.12569597
22regulation of helicase activity (GO:0051095)3.12474348
23mitochondrial respiratory chain complex assembly (GO:0033108)3.09575620
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08579607
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.08579607
26resolution of meiotic recombination intermediates (GO:0000712)3.06866960
27protein complex biogenesis (GO:0070271)3.06716884
28protein-cofactor linkage (GO:0018065)3.05933752
29regulation of centriole replication (GO:0046599)3.03877084
30mitochondrial respiratory chain complex I assembly (GO:0032981)2.98540459
31NADH dehydrogenase complex assembly (GO:0010257)2.98540459
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98540459
33protein neddylation (GO:0045116)2.98315858
34fucose catabolic process (GO:0019317)2.94722787
35L-fucose metabolic process (GO:0042354)2.94722787
36L-fucose catabolic process (GO:0042355)2.94722787
37reciprocal meiotic recombination (GO:0007131)2.93575097
38reciprocal DNA recombination (GO:0035825)2.93575097
39kidney morphogenesis (GO:0060993)2.91747957
40regulation of mesoderm development (GO:2000380)2.91530219
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90036885
42neural tube formation (GO:0001841)2.88403445
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88049264
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.88049264
45regulation of translation, ncRNA-mediated (GO:0045974)2.88049264
46establishment of protein localization to mitochondrial membrane (GO:0090151)2.87438231
47somite rostral/caudal axis specification (GO:0032525)2.85583362
48cytochrome complex assembly (GO:0017004)2.85025901
49regulation of posttranscriptional gene silencing (GO:0060147)2.80685996
50regulation of gene silencing by miRNA (GO:0060964)2.80685996
51regulation of gene silencing by RNA (GO:0060966)2.80685996
52rRNA catabolic process (GO:0016075)2.78829692
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78711875
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73061119
55ncRNA catabolic process (GO:0034661)2.72929687
56DNA deamination (GO:0045006)2.71659107
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71611241
58negative regulation of telomere maintenance (GO:0032205)2.70939432
59preassembly of GPI anchor in ER membrane (GO:0016254)2.68309625
60piRNA metabolic process (GO:0034587)2.68152477
61single strand break repair (GO:0000012)2.67598216
62epithelial cilium movement (GO:0003351)2.64406647
63platelet dense granule organization (GO:0060155)2.59983501
64DNA replication-dependent nucleosome assembly (GO:0006335)2.58464619
65DNA replication-dependent nucleosome organization (GO:0034723)2.58464619
66protein K6-linked ubiquitination (GO:0085020)2.57682958
67indolalkylamine metabolic process (GO:0006586)2.56507168
68DNA integration (GO:0015074)2.56491852
69postreplication repair (GO:0006301)2.55049689
70negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55043041
71protein prenylation (GO:0018342)2.54415289
72prenylation (GO:0097354)2.54415289
73regulation of centrosome duplication (GO:0010824)2.54139739
74DNA catabolic process, exonucleolytic (GO:0000738)2.52793122
75axoneme assembly (GO:0035082)2.52730032
76intraciliary transport (GO:0042073)2.51953232
77DNA replication-independent nucleosome organization (GO:0034724)2.51670522
78DNA replication-independent nucleosome assembly (GO:0006336)2.51670522
79kinetochore organization (GO:0051383)2.50974524
80cilium morphogenesis (GO:0060271)2.50768421
81somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50345226
82isotype switching (GO:0045190)2.50345226
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50345226
84DNA strand renaturation (GO:0000733)2.49416710
85male meiosis (GO:0007140)2.48590954
86maturation of 5.8S rRNA (GO:0000460)2.48098683
87meiotic chromosome segregation (GO:0045132)2.47272883
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46781732
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46781732
90kinetochore assembly (GO:0051382)2.46070614
91cullin deneddylation (GO:0010388)2.45877541
92regulation of telomere maintenance (GO:0032204)2.45831591
93regulation of centrosome cycle (GO:0046605)2.45674786
94histone mRNA metabolic process (GO:0008334)2.44855786
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44317824
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43677966
97nonmotile primary cilium assembly (GO:0035058)2.42101049
98somite development (GO:0061053)2.41846036
99protein polyglutamylation (GO:0018095)2.41140741
100positive regulation of histone H3-K4 methylation (GO:0051571)2.39935372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.68027366
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.97451094
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97445246
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.95187377
5VDR_22108803_ChIP-Seq_LS180_Human2.81647257
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.62264459
7EWS_26573619_Chip-Seq_HEK293_Human2.51527135
8FUS_26573619_Chip-Seq_HEK293_Human2.48280888
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47830584
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.47343561
11IGF1R_20145208_ChIP-Seq_DFB_Human2.40753418
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39771662
13GBX2_23144817_ChIP-Seq_PC3_Human2.38798339
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35650182
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25771901
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22490446
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.16682917
18TAF15_26573619_Chip-Seq_HEK293_Human2.14027934
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08690869
20ELK1_19687146_ChIP-ChIP_HELA_Human2.03743296
21P300_19829295_ChIP-Seq_ESCs_Human2.01308319
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95113461
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93624169
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86582499
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86013848
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.84572151
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81064484
28IRF1_19129219_ChIP-ChIP_H3396_Human1.80119573
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77605167
30EZH2_22144423_ChIP-Seq_EOC_Human1.71067681
31* MYC_18940864_ChIP-ChIP_HL60_Human1.67842382
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67468764
33VDR_23849224_ChIP-Seq_CD4+_Human1.65904978
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64313740
35ER_23166858_ChIP-Seq_MCF-7_Human1.63604509
36E2F7_22180533_ChIP-Seq_HELA_Human1.62400556
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57682770
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47139897
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43308955
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39651674
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.39575564
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37591343
43* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37451547
44FOXP3_21729870_ChIP-Seq_TREG_Human1.36759045
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36377365
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.36114885
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35184425
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33893984
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.29624480
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29388819
51TP53_22573176_ChIP-Seq_HFKS_Human1.27361075
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26702841
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26191418
54CBP_20019798_ChIP-Seq_JUKART_Human1.26191418
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24947109
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22171870
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.22073588
58SMAD4_21799915_ChIP-Seq_A2780_Human1.21958619
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20895947
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20433201
61BCAT_22108803_ChIP-Seq_LS180_Human1.20266836
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.20208114
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20151076
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20151076
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.19795940
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19444072
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19093733
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.18355185
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18355185
70SOX2_19829295_ChIP-Seq_ESCs_Human1.18203524
71NANOG_19829295_ChIP-Seq_ESCs_Human1.18203524
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17859403
73STAT3_23295773_ChIP-Seq_U87_Human1.17225700
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15709211
75TCF4_23295773_ChIP-Seq_U87_Human1.14033528
76AR_25329375_ChIP-Seq_VCAP_Human1.13818026
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13358641
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.13082378
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12187485
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11502368
81RNF2_27304074_Chip-Seq_NSC_Mouse1.09784158
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.09526845
83RUNX2_22187159_ChIP-Seq_PCA_Human1.09176121
84TCF4_22108803_ChIP-Seq_LS180_Human1.08513228
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07810868
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07748313
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06916690
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04682456
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03811654
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03783371
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01456290
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99863736
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.99803049
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97992703
95AR_20517297_ChIP-Seq_VCAP_Human0.97427216
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96672143
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.96663504
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.95825237
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95519962
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.94968898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.34839573
2MP0002102_abnormal_ear_morphology2.81347524
3MP0008058_abnormal_DNA_repair2.62326903
4MP0003136_yellow_coat_color2.49325459
5MP0008057_abnormal_DNA_replication2.37454908
6MP0006072_abnormal_retinal_apoptosis2.27550148
7MP0003890_abnormal_embryonic-extraembry2.24815557
8MP0006292_abnormal_olfactory_placode2.21470659
9MP0003693_abnormal_embryo_hatching2.14355369
10MP0003787_abnormal_imprinting2.04130931
11MP0002938_white_spotting2.02776420
12MP0010094_abnormal_chromosome_stability2.02421889
13MP0005551_abnormal_eye_electrophysiolog1.88699445
14MP0000569_abnormal_digit_pigmentation1.87895262
15MP0004133_heterotaxia1.87801756
16MP0005253_abnormal_eye_physiology1.76423380
17MP0002736_abnormal_nociception_after1.76235228
18MP0005645_abnormal_hypothalamus_physiol1.72239165
19MP0001968_abnormal_touch/_nociception1.71306293
20MP0003121_genomic_imprinting1.70592257
21MP0002653_abnormal_ependyma_morphology1.69744023
22MP0002837_dystrophic_cardiac_calcinosis1.64619171
23MP0001293_anophthalmia1.63797076
24MP0000631_abnormal_neuroendocrine_gland1.62975679
25MP0003195_calcinosis1.62309139
26MP0003122_maternal_imprinting1.62046693
27MP0003718_maternal_effect1.61561549
28MP0001485_abnormal_pinna_reflex1.59198334
29MP0001529_abnormal_vocalization1.58177570
30MP0003937_abnormal_limbs/digits/tail_de1.55107297
31MP0003011_delayed_dark_adaptation1.54278238
32MP0008872_abnormal_physiological_respon1.53017469
33MP0005075_abnormal_melanosome_morpholog1.50777991
34MP0003567_abnormal_fetal_cardiomyocyte1.50659710
35MP0004147_increased_porphyrin_level1.50459110
36MP0004885_abnormal_endolymph1.49179954
37MP0002638_abnormal_pupillary_reflex1.44468138
38MP0000372_irregular_coat_pigmentation1.42303182
39MP0003880_abnormal_central_pattern1.39960821
40MP0005174_abnormal_tail_pigmentation1.38900405
41MP0009046_muscle_twitch1.37843341
42MP0006276_abnormal_autonomic_nervous1.36821009
43MP0005646_abnormal_pituitary_gland1.35438504
44MP0005379_endocrine/exocrine_gland_phen1.33550008
45MP0001986_abnormal_taste_sensitivity1.32597791
46MP0001188_hyperpigmentation1.31756089
47MP0005084_abnormal_gallbladder_morpholo1.30370214
48MP0003283_abnormal_digestive_organ1.29806324
49MP0000427_abnormal_hair_cycle1.29498733
50MP0003119_abnormal_digestive_system1.27582749
51MP0002751_abnormal_autonomic_nervous1.27067975
52MP0009745_abnormal_behavioral_response1.19902761
53MP0002210_abnormal_sex_determination1.17244627
54MP0004142_abnormal_muscle_tone1.16447328
55MP0002160_abnormal_reproductive_system1.15559235
56MP0001929_abnormal_gametogenesis1.15219151
57MP0002095_abnormal_skin_pigmentation1.14303297
58MP0004957_abnormal_blastocyst_morpholog1.13177015
59MP0002272_abnormal_nervous_system1.13168667
60MP0003646_muscle_fatigue1.12782822
61MP0002163_abnormal_gland_morphology1.12054481
62MP0008995_early_reproductive_senescence1.08991707
63MP0002735_abnormal_chemical_nociception1.08665217
64MP0004215_abnormal_myocardial_fiber1.06584089
65MP0001984_abnormal_olfaction1.02541631
66MP0005389_reproductive_system_phenotype1.01440188
67MP0000383_abnormal_hair_follicle1.01259329
68MP0000647_abnormal_sebaceous_gland1.00103282
69MP0000653_abnormal_sex_gland1.00003359
70MP0001145_abnormal_male_reproductive0.99692104
71MP0002277_abnormal_respiratory_mucosa0.99631720
72MP0003698_abnormal_male_reproductive0.97695188
73MP0001486_abnormal_startle_reflex0.97664504
74MP0001286_abnormal_eye_development0.97402520
75MP0003077_abnormal_cell_cycle0.97189402
76MP0003111_abnormal_nucleus_morphology0.97093186
77MP0002557_abnormal_social/conspecific_i0.96550951
78MP0009697_abnormal_copulation0.96354264
79MP0000778_abnormal_nervous_system0.92050962
80MP0000049_abnormal_middle_ear0.91753898
81MP0003786_premature_aging0.91583837
82MP0005195_abnormal_posterior_eye0.91571206
83MP0005391_vision/eye_phenotype0.90706178
84MP0004043_abnormal_pH_regulation0.88755680
85MP0008789_abnormal_olfactory_epithelium0.84818662
86MP0006035_abnormal_mitochondrial_morpho0.84396503
87MP0002254_reproductive_system_inflammat0.83456982
88MP0001324_abnormal_eye_pigmentation0.81893215
89MP0004742_abnormal_vestibular_system0.79942876
90MP0002752_abnormal_somatic_nervous0.79742609
91MP0002572_abnormal_emotion/affect_behav0.79644802
92MP0002734_abnormal_mechanical_nocicepti0.79626193
93MP0002233_abnormal_nose_morphology0.79426970
94MP0003137_abnormal_impulse_conducting0.78752628
95MP0001919_abnormal_reproductive_system0.78103172
96MP0008932_abnormal_embryonic_tissue0.76559114
97MP0004924_abnormal_behavior0.75279980
98MP0005386_behavior/neurological_phenoty0.75279980
99MP0001119_abnormal_female_reproductive0.74225516
100MP0005377_hearing/vestibular/ear_phenot0.73918648

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.71550931
2Colon cancer (HP:0003003)3.53406303
3Pancreatic fibrosis (HP:0100732)3.29784679
4True hermaphroditism (HP:0010459)3.28812811
5Abnormality of midbrain morphology (HP:0002418)3.18480664
6Molar tooth sign on MRI (HP:0002419)3.18480664
7Nephronophthisis (HP:0000090)2.86576794
8Abnormality of the labia minora (HP:0012880)2.84021612
9Congenital stationary night blindness (HP:0007642)2.80694501
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.64220581
11Abnormality of the renal cortex (HP:0011035)2.50825401
12Abnormality of the renal medulla (HP:0100957)2.50617615
13Meckel diverticulum (HP:0002245)2.46080744
14Medial flaring of the eyebrow (HP:0010747)2.45231961
15Type II lissencephaly (HP:0007260)2.40233453
16Abnormality of the ileum (HP:0001549)2.39978445
17Abolished electroretinogram (ERG) (HP:0000550)2.36494043
18Pendular nystagmus (HP:0012043)2.34001218
19Intestinal atresia (HP:0011100)2.32525387
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30471168
21Septo-optic dysplasia (HP:0100842)2.28043441
22Chromsome breakage (HP:0040012)2.25401140
23Chronic hepatic failure (HP:0100626)2.25307877
24Attenuation of retinal blood vessels (HP:0007843)2.23200151
25Inability to walk (HP:0002540)2.22332276
26Abnormality of chromosome stability (HP:0003220)2.19704054
27Progressive inability to walk (HP:0002505)2.19146020
28Sclerocornea (HP:0000647)2.17878626
29Hyperglycinemia (HP:0002154)2.17190621
30Lissencephaly (HP:0001339)2.16381733
31Birth length less than 3rd percentile (HP:0003561)2.14682673
32Acute necrotizing encephalopathy (HP:0006965)2.14638464
33Methylmalonic acidemia (HP:0002912)2.13233898
34Abnormal biliary tract physiology (HP:0012439)2.11555263
35Bile duct proliferation (HP:0001408)2.11555263
36Hyperglycinuria (HP:0003108)2.10980291
37Hyperventilation (HP:0002883)2.10462949
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09903010
39Cystic liver disease (HP:0006706)2.08669055
40Acute encephalopathy (HP:0006846)2.08576207
41Increased CSF lactate (HP:0002490)2.06365060
42Optic nerve hypoplasia (HP:0000609)2.06164406
43Neoplasm of the adrenal cortex (HP:0100641)2.02807934
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02118446
45Abnormality of alanine metabolism (HP:0010916)2.02118446
46Hyperalaninemia (HP:0003348)2.02118446
47Anencephaly (HP:0002323)2.01722840
48Bilateral microphthalmos (HP:0007633)1.99737330
49Genital tract atresia (HP:0001827)1.97989026
50Increased hepatocellular lipid droplets (HP:0006565)1.96953462
51Progressive macrocephaly (HP:0004481)1.95218905
52Vaginal atresia (HP:0000148)1.94630194
53Nephrogenic diabetes insipidus (HP:0009806)1.93955306
54Mitochondrial inheritance (HP:0001427)1.93856475
55Hypoplasia of the pons (HP:0012110)1.93760604
56Congenital primary aphakia (HP:0007707)1.93243411
57Gait imbalance (HP:0002141)1.92921748
58Renal cortical cysts (HP:0000803)1.92574310
59Lipid accumulation in hepatocytes (HP:0006561)1.91700371
60Abnormality of the pons (HP:0007361)1.91202985
61Sloping forehead (HP:0000340)1.90880515
623-Methylglutaconic aciduria (HP:0003535)1.90173063
63Supernumerary spleens (HP:0009799)1.89682600
64Volvulus (HP:0002580)1.88985237
65Hypothermia (HP:0002045)1.87926885
66Abnormality of the preputium (HP:0100587)1.87891811
67Triphalangeal thumb (HP:0001199)1.87276411
68Tubular atrophy (HP:0000092)1.86849832
69Bifid tongue (HP:0010297)1.86531681
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.85967919
71Dandy-Walker malformation (HP:0001305)1.83867081
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.82703655
73Anophthalmia (HP:0000528)1.82474929
74Cerebellar dysplasia (HP:0007033)1.82211771
75Methylmalonic aciduria (HP:0012120)1.81118691
76Abnormality of serine family amino acid metabolism (HP:0010894)1.79640495
77Abnormality of glycine metabolism (HP:0010895)1.79640495
78Patellar aplasia (HP:0006443)1.79430878
79Absent thumb (HP:0009777)1.79259981
80Male pseudohermaphroditism (HP:0000037)1.78700089
81Abnormal lung lobation (HP:0002101)1.78590916
82Clubbing of toes (HP:0100760)1.78553080
83Preaxial hand polydactyly (HP:0001177)1.77908285
84Abnormality of the duodenum (HP:0002246)1.75107218
85Abnormal rod and cone electroretinograms (HP:0008323)1.74398426
86Decreased central vision (HP:0007663)1.73458934
87Stomach cancer (HP:0012126)1.72212850
88Postaxial foot polydactyly (HP:0001830)1.71443670
89Small hand (HP:0200055)1.70229250
90Gastrointestinal atresia (HP:0002589)1.70209246
91Aplasia/Hypoplasia of the patella (HP:0006498)1.69645267
92Abnormal mitochondria in muscle tissue (HP:0008316)1.68725116
93Aplasia/Hypoplasia of the spleen (HP:0010451)1.68336256
94Abnormality of serum amino acid levels (HP:0003112)1.66742327
95Duodenal stenosis (HP:0100867)1.66315570
96Small intestinal stenosis (HP:0012848)1.66315570
97Furrowed tongue (HP:0000221)1.66024703
98Congenital, generalized hypertrichosis (HP:0004540)1.65507289
99Polydipsia (HP:0001959)1.65319664
100Abnormal drinking behavior (HP:0030082)1.65319664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.36781566
2ZAK3.06020497
3WNK32.94564913
4NUAK12.79893631
5BMPR1B2.72223662
6MKNK22.41229227
7TRIM282.35162097
8ACVR1B2.33490282
9VRK22.21532866
10MAP4K22.12564383
11PNCK2.07159422
12PLK42.00125773
13TAF11.93994937
14CASK1.89942925
15TSSK61.86918359
16TNIK1.81363862
17MKNK11.78628289
18MAP3K41.76206070
19GRK11.76189843
20VRK11.75723621
21ADRBK21.72272084
22SRPK11.71293676
23WEE11.67103755
24PLK31.62652009
25CDC71.60631148
26TLK11.54698230
27BRSK21.52451816
28PINK11.49886575
29EIF2AK31.41276145
30INSRR1.34595243
31STK38L1.30218606
32WNK41.29299787
33MST41.28903262
34TTK1.28860002
35DYRK21.28449742
36MAPK131.27559508
37STK161.23510130
38OXSR11.21870022
39CSNK1G11.18025557
40TGFBR11.16643998
41PASK1.15218237
42BCR1.14639181
43TAOK31.11415995
44DYRK31.09090536
45CSNK1G21.06655323
46BUB11.05584095
47PBK1.03230519
48STK391.02662405
49CDK190.98074141
50CSNK1G30.97441892
51PLK10.97419998
52PLK20.94928377
53MAP2K70.90932754
54PRKCG0.80129191
55ERBB30.76567766
56ATR0.76350266
57STK30.75971177
58NLK0.73844863
59EIF2AK20.72680529
60BCKDK0.70701834
61CSNK1A1L0.70491149
62FGFR20.69291209
63CHEK20.68078030
64PRKCE0.67618399
65NME10.65260502
66NEK20.63484687
67EIF2AK10.58930375
68ATM0.58870480
69PAK30.58597582
70RPS6KA40.57002500
71EPHA40.56717489
72CDK30.56610717
73RPS6KA50.55387682
74NEK10.53759164
75LATS10.53061280
76MAPKAPK50.51288101
77ADRBK10.49027021
78TXK0.46349119
79TIE10.44761559
80NTRK20.42412278
81CAMKK20.38730401
82TEC0.38691674
83CSNK1D0.37887556
84DYRK1A0.37241665
85DAPK20.36165981
86MAP3K120.35805563
87CSNK1A10.35550556
88CSNK1E0.34259694
89CSNK2A10.33651828
90AURKB0.33223778
91BRSK10.33189436
92PRKCI0.33144201
93STK110.32314484
94PRKCQ0.32241951
95MARK10.29560855
96MELK0.27707257
97CSNK2A20.27398040
98CAMK10.27031479
99PKN10.26577311
100CAMK1G0.26508162

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.05852223
2Protein export_Homo sapiens_hsa030602.95664756
3Fanconi anemia pathway_Homo sapiens_hsa034602.68360127
4Basal transcription factors_Homo sapiens_hsa030222.45720046
5Mismatch repair_Homo sapiens_hsa034302.36870831
6RNA polymerase_Homo sapiens_hsa030202.36707828
7Oxidative phosphorylation_Homo sapiens_hsa001902.34488628
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29344255
9Phototransduction_Homo sapiens_hsa047442.26040590
10RNA degradation_Homo sapiens_hsa030182.22416916
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22174867
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07720921
13Non-homologous end-joining_Homo sapiens_hsa034502.00487704
14Proteasome_Homo sapiens_hsa030501.96639580
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95106282
16Propanoate metabolism_Homo sapiens_hsa006401.91426602
17Butanoate metabolism_Homo sapiens_hsa006501.88193977
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86102890
19Selenocompound metabolism_Homo sapiens_hsa004501.85186493
20Parkinsons disease_Homo sapiens_hsa050121.84700311
21One carbon pool by folate_Homo sapiens_hsa006701.66570916
22Nitrogen metabolism_Homo sapiens_hsa009101.66476930
23Ribosome_Homo sapiens_hsa030101.63165444
24RNA transport_Homo sapiens_hsa030131.60403942
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.60256873
26Steroid biosynthesis_Homo sapiens_hsa001001.59840633
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55484795
28DNA replication_Homo sapiens_hsa030301.51848909
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51460002
30Linoleic acid metabolism_Homo sapiens_hsa005911.47445927
31Nucleotide excision repair_Homo sapiens_hsa034201.46400338
32Nicotine addiction_Homo sapiens_hsa050331.46388264
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42419283
34Huntingtons disease_Homo sapiens_hsa050161.40651723
35Base excision repair_Homo sapiens_hsa034101.36356699
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31389100
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28154405
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25669741
39Ether lipid metabolism_Homo sapiens_hsa005651.20365683
40Spliceosome_Homo sapiens_hsa030401.17214727
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16643226
42Tryptophan metabolism_Homo sapiens_hsa003801.13075534
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10370179
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.09618085
45Purine metabolism_Homo sapiens_hsa002301.08948811
46Alzheimers disease_Homo sapiens_hsa050101.03645939
47Cell cycle_Homo sapiens_hsa041101.00973469
48Taste transduction_Homo sapiens_hsa047420.99872437
49Caffeine metabolism_Homo sapiens_hsa002320.96987829
50Peroxisome_Homo sapiens_hsa041460.92997290
51Pyrimidine metabolism_Homo sapiens_hsa002400.92051781
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91352682
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90630490
54Regulation of autophagy_Homo sapiens_hsa041400.88114166
55Olfactory transduction_Homo sapiens_hsa047400.86036367
56Cardiac muscle contraction_Homo sapiens_hsa042600.85091373
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83772760
58Retinol metabolism_Homo sapiens_hsa008300.79028023
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74541751
60Metabolic pathways_Homo sapiens_hsa011000.69166441
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.65986256
62Morphine addiction_Homo sapiens_hsa050320.65323314
63Basal cell carcinoma_Homo sapiens_hsa052170.64819839
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.64603081
65Fatty acid elongation_Homo sapiens_hsa000620.64400151
66mRNA surveillance pathway_Homo sapiens_hsa030150.63844153
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62006230
68GABAergic synapse_Homo sapiens_hsa047270.59999267
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59456823
70p53 signaling pathway_Homo sapiens_hsa041150.59389898
71Collecting duct acid secretion_Homo sapiens_hsa049660.57286636
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56756193
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53785190
74Oocyte meiosis_Homo sapiens_hsa041140.53163492
75Serotonergic synapse_Homo sapiens_hsa047260.52921278
76beta-Alanine metabolism_Homo sapiens_hsa004100.52652160
77Sulfur metabolism_Homo sapiens_hsa009200.52539363
78Chemical carcinogenesis_Homo sapiens_hsa052040.52517987
79Pyruvate metabolism_Homo sapiens_hsa006200.51291967
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50970625
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50319261
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49411293
83Hedgehog signaling pathway_Homo sapiens_hsa043400.49037977
84Primary immunodeficiency_Homo sapiens_hsa053400.48507214
85Fatty acid metabolism_Homo sapiens_hsa012120.48388759
86Glutamatergic synapse_Homo sapiens_hsa047240.47730377
87Circadian entrainment_Homo sapiens_hsa047130.46507259
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45162174
89TGF-beta signaling pathway_Homo sapiens_hsa043500.44539678
90Insulin secretion_Homo sapiens_hsa049110.43028059
91Arachidonic acid metabolism_Homo sapiens_hsa005900.41902882
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39753742
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39622870
94Vitamin digestion and absorption_Homo sapiens_hsa049770.39379634
95Folate biosynthesis_Homo sapiens_hsa007900.38670829
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38443968
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34997426
98Hippo signaling pathway_Homo sapiens_hsa043900.32072050
99Dopaminergic synapse_Homo sapiens_hsa047280.30983212
100Vitamin B6 metabolism_Homo sapiens_hsa007500.30523488

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