ZNF684

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose metabolic process (GO:0042354)4.05989652
2L-fucose catabolic process (GO:0042355)4.05989652
3fucose catabolic process (GO:0019317)4.05989652
4DNA deamination (GO:0045006)4.05884229
5behavioral response to nicotine (GO:0035095)4.02175412
6cellular ketone body metabolic process (GO:0046950)3.90283697
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87544069
8platelet dense granule organization (GO:0060155)3.82572334
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68427028
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.68427028
11NADH dehydrogenase complex assembly (GO:0010257)3.68427028
12ketone body metabolic process (GO:1902224)3.65793839
13piRNA metabolic process (GO:0034587)3.64608073
14protein complex biogenesis (GO:0070271)3.57655317
15mannosylation (GO:0097502)3.55860230
16replication fork processing (GO:0031297)3.50980182
17preassembly of GPI anchor in ER membrane (GO:0016254)3.50814688
18water-soluble vitamin biosynthetic process (GO:0042364)3.49141338
19respiratory chain complex IV assembly (GO:0008535)3.48424852
20mitochondrial respiratory chain complex assembly (GO:0033108)3.42420723
21detection of light stimulus involved in sensory perception (GO:0050962)3.34236782
22detection of light stimulus involved in visual perception (GO:0050908)3.34236782
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.30565424
24protein-cofactor linkage (GO:0018065)3.30377488
25response to pheromone (GO:0019236)3.23990644
26S-adenosylmethionine metabolic process (GO:0046500)3.23844283
27indolalkylamine metabolic process (GO:0006586)3.23552234
28protein K6-linked ubiquitination (GO:0085020)3.23271243
29regulation of meiosis I (GO:0060631)3.18992307
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11747035
31synapsis (GO:0007129)3.09438726
32tryptophan catabolic process (GO:0006569)3.07581240
33indole-containing compound catabolic process (GO:0042436)3.07581240
34indolalkylamine catabolic process (GO:0046218)3.07581240
35recombinational repair (GO:0000725)3.06011837
36cytochrome complex assembly (GO:0017004)3.05812301
37DNA methylation involved in gamete generation (GO:0043046)3.04320165
38double-strand break repair via homologous recombination (GO:0000724)3.01503778
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98144778
40centriole replication (GO:0007099)2.95242303
41reciprocal meiotic recombination (GO:0007131)2.92925901
42reciprocal DNA recombination (GO:0035825)2.92925901
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92734316
44axoneme assembly (GO:0035082)2.92722642
45rRNA catabolic process (GO:0016075)2.89770444
46negative regulation of DNA-dependent DNA replication (GO:2000104)2.89178590
47regulation of cilium movement (GO:0003352)2.87917092
48tryptophan metabolic process (GO:0006568)2.87571836
49peptidyl-histidine modification (GO:0018202)2.87166182
50kynurenine metabolic process (GO:0070189)2.85252393
51regulation of hexokinase activity (GO:1903299)2.84824426
52regulation of glucokinase activity (GO:0033131)2.84824426
53auditory receptor cell stereocilium organization (GO:0060088)2.83182940
54pseudouridine synthesis (GO:0001522)2.83121160
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82245518
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80881962
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80881962
58isotype switching (GO:0045190)2.80881962
59retinal cone cell development (GO:0046549)2.77967265
60regulation of mitotic spindle checkpoint (GO:1903504)2.77435373
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77435373
62tRNA processing (GO:0008033)2.75268901
63DNA double-strand break processing (GO:0000729)2.75118981
64nonmotile primary cilium assembly (GO:0035058)2.72965231
65polyol catabolic process (GO:0046174)2.72473143
66protein deneddylation (GO:0000338)2.70974775
67epithelial cilium movement (GO:0003351)2.69673766
68branched-chain amino acid catabolic process (GO:0009083)2.69349899
69inositol phosphate catabolic process (GO:0071545)2.66421166
70protein polyglutamylation (GO:0018095)2.66326317
71cullin deneddylation (GO:0010388)2.66028435
72adaptation of signaling pathway (GO:0023058)2.65102188
73adenosine metabolic process (GO:0046085)2.64020111
74L-methionine salvage (GO:0071267)2.62599403
75L-methionine biosynthetic process (GO:0071265)2.62599403
76amino acid salvage (GO:0043102)2.62599403
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62532385
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61704228
79photoreceptor cell maintenance (GO:0045494)2.60795517
80cilium morphogenesis (GO:0060271)2.58621844
81C-terminal protein amino acid modification (GO:0018410)2.58202248
82postreplication repair (GO:0006301)2.58091965
83negative regulation of telomere maintenance (GO:0032205)2.58017068
84cellular biogenic amine catabolic process (GO:0042402)2.57566361
85amine catabolic process (GO:0009310)2.57566361
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.57341961
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56660049
88GPI anchor metabolic process (GO:0006505)2.56497929
89male meiosis I (GO:0007141)2.55296279
90C-terminal protein lipidation (GO:0006501)2.54951989
91anterograde synaptic vesicle transport (GO:0048490)2.54645688
92protein K11-linked deubiquitination (GO:0035871)2.53557945
93male meiosis (GO:0007140)2.53322091
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53184648
95proteasome assembly (GO:0043248)2.52872421
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52404302
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52404302
98phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51740804
99inositol phosphate dephosphorylation (GO:0046855)2.51740804
100C4-dicarboxylate transport (GO:0015740)2.50135432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.82027875
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02689930
3VDR_22108803_ChIP-Seq_LS180_Human2.89078317
4* GABP_17652178_ChIP-ChIP_JURKAT_Human2.72418737
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58641634
6IGF1R_20145208_ChIP-Seq_DFB_Human2.57784609
7GBX2_23144817_ChIP-Seq_PC3_Human2.53747720
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.51970366
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50959379
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.46724602
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32946737
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29814222
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26012850
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25227924
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22676100
16EWS_26573619_Chip-Seq_HEK293_Human2.20810144
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.17855015
18FUS_26573619_Chip-Seq_HEK293_Human2.03434941
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94655859
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.91238056
21P300_19829295_ChIP-Seq_ESCs_Human1.89253347
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88522173
23* ELK1_19687146_ChIP-ChIP_HELA_Human1.86279312
24TAF15_26573619_Chip-Seq_HEK293_Human1.85842178
25VDR_23849224_ChIP-Seq_CD4+_Human1.83501327
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81265452
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79092687
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71484944
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70073423
30MYC_18940864_ChIP-ChIP_HL60_Human1.68123905
31IRF1_19129219_ChIP-ChIP_H3396_Human1.65573648
32ER_23166858_ChIP-Seq_MCF-7_Human1.63282939
33TP53_22573176_ChIP-Seq_HFKS_Human1.61752000
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.54344441
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.52208244
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50611284
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49521721
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48986560
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46429740
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.45630539
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44281073
42CBP_20019798_ChIP-Seq_JUKART_Human1.44281073
43FOXP3_21729870_ChIP-Seq_TREG_Human1.43608837
44BCAT_22108803_ChIP-Seq_LS180_Human1.43246668
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.41787000
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41787000
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40871805
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40398934
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38297701
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.37507318
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37209933
52SOX2_19829295_ChIP-Seq_ESCs_Human1.36082959
53NANOG_19829295_ChIP-Seq_ESCs_Human1.36082959
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34372929
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30635810
56STAT3_23295773_ChIP-Seq_U87_Human1.27619101
57TCF4_22108803_ChIP-Seq_LS180_Human1.26722248
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.26193695
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25951968
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25889470
61EZH2_22144423_ChIP-Seq_EOC_Human1.25027474
62TCF4_23295773_ChIP-Seq_U87_Human1.24499345
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24273907
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24183370
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22634329
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22301212
67SMAD4_21799915_ChIP-Seq_A2780_Human1.20390170
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19570171
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18883824
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18114907
71AR_20517297_ChIP-Seq_VCAP_Human1.17962168
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17380345
73HOXB7_26014856_ChIP-Seq_BT474_Human1.16931594
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16441016
75NCOR_22424771_ChIP-Seq_293T_Human1.16217449
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.14447179
77AR_25329375_ChIP-Seq_VCAP_Human1.13399699
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.12872827
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11436794
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10341783
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10144693
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09979048
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.09924685
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09912485
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08990019
86P53_22387025_ChIP-Seq_ESCs_Mouse1.06549234
87RUNX2_22187159_ChIP-Seq_PCA_Human1.06507724
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06243402
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05262361
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.04580077
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03899262
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.03892365
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02089235
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02089235
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.00747384
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00350301
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00287970
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00270359
99* CDX2_22108803_ChIP-Seq_LS180_Human0.99779653
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98707997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.45481005
2MP0003195_calcinosis3.35606950
3MP0000372_irregular_coat_pigmentation2.98319532
4MP0006292_abnormal_olfactory_placode2.87276797
5MP0000569_abnormal_digit_pigmentation2.73417485
6MP0002102_abnormal_ear_morphology2.67941388
7MP0006072_abnormal_retinal_apoptosis2.67637972
8MP0002837_dystrophic_cardiac_calcinosis2.56839080
9MP0005551_abnormal_eye_electrophysiolog2.44254939
10MP0005075_abnormal_melanosome_morpholog2.18180865
11MP0003136_yellow_coat_color2.08885874
12MP0005174_abnormal_tail_pigmentation2.06032338
13MP0004147_increased_porphyrin_level2.02762749
14MP0005253_abnormal_eye_physiology1.99386460
15MP0008875_abnormal_xenobiotic_pharmacok1.94555133
16MP0002163_abnormal_gland_morphology1.93656723
17MP0003646_muscle_fatigue1.91485099
18MP0002638_abnormal_pupillary_reflex1.91456213
19MP0002876_abnormal_thyroid_physiology1.89869385
20MP0001986_abnormal_taste_sensitivity1.89322803
21MP0003787_abnormal_imprinting1.87169336
22MP0008058_abnormal_DNA_repair1.83774278
23MP0008872_abnormal_physiological_respon1.80973375
24MP0002938_white_spotting1.80015112
25MP0000427_abnormal_hair_cycle1.71437267
26MP0005645_abnormal_hypothalamus_physiol1.67147820
27MP0005646_abnormal_pituitary_gland1.62130307
28MP0002138_abnormal_hepatobiliary_system1.60635162
29MP0009046_muscle_twitch1.59023034
30MP0003718_maternal_effect1.55512886
31MP0004043_abnormal_pH_regulation1.53932862
32MP0001968_abnormal_touch/_nociception1.53571521
33MP0004142_abnormal_muscle_tone1.50516617
34MP0005379_endocrine/exocrine_gland_phen1.49607588
35MP0003011_delayed_dark_adaptation1.34491711
36MP0005084_abnormal_gallbladder_morpholo1.33899104
37MP0001501_abnormal_sleep_pattern1.33633119
38MP0002095_abnormal_skin_pigmentation1.30202408
39MP0000015_abnormal_ear_pigmentation1.26943894
40MP0002234_abnormal_pharynx_morphology1.21518531
41MP0010094_abnormal_chromosome_stability1.20885799
42MP0002272_abnormal_nervous_system1.20670151
43MP0001984_abnormal_olfaction1.20578558
44MP0009745_abnormal_behavioral_response1.20235252
45MP0003806_abnormal_nucleotide_metabolis1.20204508
46MP0003890_abnormal_embryonic-extraembry1.19933544
47MP0002736_abnormal_nociception_after1.17743722
48MP0001529_abnormal_vocalization1.17129477
49MP0010386_abnormal_urinary_bladder1.16800541
50MP0005389_reproductive_system_phenotype1.16333569
51MP0002160_abnormal_reproductive_system1.15719378
52MP0003880_abnormal_central_pattern1.15125892
53MP0006276_abnormal_autonomic_nervous1.14609832
54MP0000631_abnormal_neuroendocrine_gland1.12794363
55MP0001764_abnormal_homeostasis1.12308840
56MP0004885_abnormal_endolymph1.11358768
57MP0005085_abnormal_gallbladder_physiolo1.09568966
58MP0005171_absent_coat_pigmentation1.09307243
59MP0006036_abnormal_mitochondrial_physio1.07175901
60MP0002090_abnormal_vision1.03727484
61MP0003786_premature_aging1.03583886
62MP0005365_abnormal_bile_salt1.03385025
63MP0005332_abnormal_amino_acid1.02646584
64MP0003186_abnormal_redox_activity1.02521865
65MP0001324_abnormal_eye_pigmentation1.02127113
66MP0001486_abnormal_startle_reflex1.00804241
67MP0003121_genomic_imprinting0.98238440
68MP0005360_urolithiasis0.97531594
69MP0008789_abnormal_olfactory_epithelium0.97508487
70MP0005671_abnormal_response_to0.95076117
71MP0008995_early_reproductive_senescence0.94174344
72MP0001929_abnormal_gametogenesis0.91742976
73MP0002254_reproductive_system_inflammat0.90084387
74MP0004133_heterotaxia0.88959055
75MP0003252_abnormal_bile_duct0.88769440
76MP0002653_abnormal_ependyma_morphology0.88651199
77MP0004742_abnormal_vestibular_system0.88112994
78MP0001485_abnormal_pinna_reflex0.87824623
79MP0005386_behavior/neurological_phenoty0.87422801
80MP0004924_abnormal_behavior0.87422801
81MP0002928_abnormal_bile_duct0.86368862
82MP0001293_anophthalmia0.85817430
83MP0000383_abnormal_hair_follicle0.85514267
84MP0001919_abnormal_reproductive_system0.85230272
85MP0004145_abnormal_muscle_electrophysio0.84684722
86MP0002751_abnormal_autonomic_nervous0.83511709
87MP0005410_abnormal_fertilization0.83414633
88MP0010329_abnormal_lipoprotein_level0.81141802
89MP0005195_abnormal_posterior_eye0.81026393
90MP0002210_abnormal_sex_determination0.79580579
91MP0002557_abnormal_social/conspecific_i0.76943443
92MP0005391_vision/eye_phenotype0.76311486
93MP0005408_hypopigmentation0.75991307
94MP0002229_neurodegeneration0.75630414
95MP0002572_abnormal_emotion/affect_behav0.75406320
96MP0003698_abnormal_male_reproductive0.75368885
97MP0008775_abnormal_heart_ventricle0.75092866
98MP0003943_abnormal_hepatobiliary_system0.73261220
99MP0009764_decreased_sensitivity_to0.73138586
100MP0000371_diluted_coat_color0.72572324

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.09002928
2Abnormality of midbrain morphology (HP:0002418)3.99457482
3Molar tooth sign on MRI (HP:0002419)3.99457482
4Congenital stationary night blindness (HP:0007642)3.97520904
5Pancreatic fibrosis (HP:0100732)3.58528952
6Nephronophthisis (HP:0000090)3.41293620
7True hermaphroditism (HP:0010459)3.36070306
8Abnormality of the renal cortex (HP:0011035)3.31517465
9Renal cortical cysts (HP:0000803)3.16163356
10Type II lissencephaly (HP:0007260)3.05731429
11Abnormality of the renal medulla (HP:0100957)2.94601686
12Medial flaring of the eyebrow (HP:0010747)2.81283404
13Acute necrotizing encephalopathy (HP:0006965)2.76399105
14Abolished electroretinogram (ERG) (HP:0000550)2.67337072
153-Methylglutaconic aciduria (HP:0003535)2.66835680
16Acute encephalopathy (HP:0006846)2.66786276
17Abnormal rod and cone electroretinograms (HP:0008323)2.56507859
18Increased CSF lactate (HP:0002490)2.56416437
19Mitochondrial inheritance (HP:0001427)2.50826412
20Progressive macrocephaly (HP:0004481)2.47443482
21Attenuation of retinal blood vessels (HP:0007843)2.41406938
22Abnormal mitochondria in muscle tissue (HP:0008316)2.37434494
23Chronic hepatic failure (HP:0100626)2.36866418
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35306283
25Abnormality of alanine metabolism (HP:0010916)2.35306283
26Hyperalaninemia (HP:0003348)2.35306283
27Hyperventilation (HP:0002883)2.32167139
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31284699
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.30012756
30Hypoplasia of the fovea (HP:0007750)2.30012756
31Congenital, generalized hypertrichosis (HP:0004540)2.25079950
32Hepatic necrosis (HP:0002605)2.22595688
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.22401363
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21175986
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.18790751
36Cystic liver disease (HP:0006706)2.17746671
37Tubular atrophy (HP:0000092)2.15196449
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.15109402
39Gait imbalance (HP:0002141)2.14007620
40Progressive inability to walk (HP:0002505)2.12586560
41Cerebellar dysplasia (HP:0007033)2.12518125
42Hepatocellular necrosis (HP:0001404)2.11385853
43Bile duct proliferation (HP:0001408)2.11079991
44Abnormal biliary tract physiology (HP:0012439)2.11079991
45Retinal dysplasia (HP:0007973)2.10050962
46Congenital primary aphakia (HP:0007707)2.09466855
47Methylmalonic acidemia (HP:0002912)2.09348108
48Decreased central vision (HP:0007663)2.09175854
49Hypothermia (HP:0002045)2.08243591
50Fair hair (HP:0002286)2.06315981
51Stomatitis (HP:0010280)2.05324804
52Albinism (HP:0001022)2.03471755
53Inability to walk (HP:0002540)2.03413495
54Optic disc pallor (HP:0000543)2.03352411
55Methylmalonic aciduria (HP:0012120)2.02682247
56Congenital hepatic fibrosis (HP:0002612)2.02078748
57Ketoacidosis (HP:0001993)2.01467808
58Abnormality of the labia minora (HP:0012880)2.01320941
59Abnormal drinking behavior (HP:0030082)2.00143388
60Polydipsia (HP:0001959)2.00143388
61Increased serum lactate (HP:0002151)1.99113529
62Abnormality of the ileum (HP:0001549)1.98500122
63Pendular nystagmus (HP:0012043)1.98181409
64Short tibia (HP:0005736)1.97891515
65Hypomagnesemia (HP:0002917)1.97418275
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95193723
67Postaxial foot polydactyly (HP:0001830)1.93324982
68Large for gestational age (HP:0001520)1.93140011
69Meckel diverticulum (HP:0002245)1.92799632
70Ketosis (HP:0001946)1.92079584
71Abnormality of the fovea (HP:0000493)1.91648378
72Broad-based gait (HP:0002136)1.90963097
73Anencephaly (HP:0002323)1.90588290
74Nephrogenic diabetes insipidus (HP:0009806)1.90196179
75Colon cancer (HP:0003003)1.89751678
76Chromsome breakage (HP:0040012)1.89514643
77Aplasia/hypoplasia of the uterus (HP:0008684)1.86919574
78Gaze-evoked nystagmus (HP:0000640)1.86666203
79Type I transferrin isoform profile (HP:0003642)1.83912140
80Sclerocornea (HP:0000647)1.83026917
81Intestinal atresia (HP:0011100)1.82927505
82Cerebral edema (HP:0002181)1.82196488
83Thyroiditis (HP:0100646)1.81350462
84Lactic acidosis (HP:0003128)1.80980496
85Polyuria (HP:0000103)1.80962595
86Lissencephaly (HP:0001339)1.78907199
87IgG deficiency (HP:0004315)1.77710830
88Abnormality of macular pigmentation (HP:0008002)1.77623414
89Lethargy (HP:0001254)1.77434763
90Hypoplasia of the uterus (HP:0000013)1.77064696
91Abnormality of chromosome stability (HP:0003220)1.76262441
92Genital tract atresia (HP:0001827)1.75656827
93Abnormality of the pons (HP:0007361)1.74857499
94Male pseudohermaphroditism (HP:0000037)1.73836231
95Furrowed tongue (HP:0000221)1.70795542
96Hypoproteinemia (HP:0003075)1.70253294
97Type 2 muscle fiber atrophy (HP:0003554)1.69005170
98Generalized hypopigmentation of hair (HP:0011358)1.68134382
99Hyperglycinuria (HP:0003108)1.67960758
100Astigmatism (HP:0000483)1.67648993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.54378776
2MAP4K23.11889200
3ZAK2.81011115
4TAOK32.79566856
5BMPR1B2.78247937
6NUAK12.69133144
7ADRBK22.49557939
8ACVR1B2.24481092
9TRIM282.23574375
10GRK12.23049437
11WNK32.14929850
12TLK11.90228974
13PINK11.81588727
14TXK1.75821043
15MAPK131.70813727
16INSRR1.65797032
17MST41.65257819
18BCKDK1.43984744
19MUSK1.39464344
20EIF2AK31.37017976
21WEE11.35558174
22WNK41.35085908
23BRSK21.34639991
24TIE11.31490979
25MAP3K41.18292756
26STK161.15760677
27ERBB31.15743536
28VRK11.15173406
29CASK1.15139814
30STK38L1.14890177
31STK31.14676834
32MKNK21.08802186
33PLK41.07726921
34OXSR11.06646647
35BUB11.06340962
36PLK31.05487225
37LATS11.02714844
38BCR1.02451024
39CAMKK21.01166259
40TNIK1.00742323
41DYRK20.96970699
42PAK30.95606182
43CSNK1G10.87718572
44TEC0.87542890
45SRPK10.86498544
46FLT30.86251439
47PRKCE0.86023352
48NEK10.85601405
49PNCK0.83363256
50CSNK1G30.80606995
51ADRBK10.79438042
52STK390.78505569
53PHKG20.78171593
54PHKG10.78171593
55IKBKB0.78078173
56TGFBR10.75987015
57DAPK20.75685464
58CSNK1G20.75451123
59CSNK1A1L0.75015446
60PLK20.74752933
61NME10.70396002
62PLK10.69807027
63IRAK10.66968547
64PRKCG0.66420788
65EIF2AK10.65383537
66NLK0.58663287
67ATR0.58274694
68CDK30.57983558
69CDC70.57760536
70KIT0.56050266
71MARK30.55687846
72VRK20.55313039
73EIF2AK20.55117160
74MAP3K120.52584024
75PBK0.52242207
76MAP2K70.52147175
77TSSK60.51277278
78CCNB10.51156921
79FGFR20.49942775
80PDK20.49745120
81FER0.47423648
82MKNK10.46934058
83ATM0.43954755
84PIK3CG0.43431236
85ITK0.42585884
86CHEK20.41991463
87PRKCI0.41955495
88PRKCQ0.40639895
89BMPR20.40541643
90NEK20.40022024
91PRKACA0.39773433
92PASK0.39768825
93CSNK1D0.39767146
94CSNK1A10.39125452
95RPS6KA50.38128890
96MAP2K60.37640576
97MARK10.36094124
98CAMK2A0.34146355
99GRK70.31799351
100PRKG10.31448360

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82859360
2Protein export_Homo sapiens_hsa030602.70238018
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56234226
4Phototransduction_Homo sapiens_hsa047442.43301788
5Homologous recombination_Homo sapiens_hsa034402.42064219
6Oxidative phosphorylation_Homo sapiens_hsa001902.41714054
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24030271
8Butanoate metabolism_Homo sapiens_hsa006502.21319792
9RNA polymerase_Homo sapiens_hsa030202.08211260
10Proteasome_Homo sapiens_hsa030502.04438335
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98900402
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.98623882
13Fanconi anemia pathway_Homo sapiens_hsa034601.97231695
14Nitrogen metabolism_Homo sapiens_hsa009101.87750560
15Propanoate metabolism_Homo sapiens_hsa006401.87664175
16Non-homologous end-joining_Homo sapiens_hsa034501.82941117
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82920190
18Parkinsons disease_Homo sapiens_hsa050121.82789539
19RNA degradation_Homo sapiens_hsa030181.82181302
20Caffeine metabolism_Homo sapiens_hsa002321.81907421
21Basal transcription factors_Homo sapiens_hsa030221.74510347
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71223167
23Linoleic acid metabolism_Homo sapiens_hsa005911.66971912
24Tryptophan metabolism_Homo sapiens_hsa003801.64069475
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59959708
26Selenocompound metabolism_Homo sapiens_hsa004501.58786459
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.47568064
28One carbon pool by folate_Homo sapiens_hsa006701.45524636
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44875460
30Peroxisome_Homo sapiens_hsa041461.42023451
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40943490
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35229626
33Ether lipid metabolism_Homo sapiens_hsa005651.31392904
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28413503
35Huntingtons disease_Homo sapiens_hsa050161.27856823
36Regulation of autophagy_Homo sapiens_hsa041401.26814371
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19761004
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18414814
39Chemical carcinogenesis_Homo sapiens_hsa052041.17063174
40Mismatch repair_Homo sapiens_hsa034301.16637009
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.12421283
42Fatty acid elongation_Homo sapiens_hsa000621.10818774
43Alzheimers disease_Homo sapiens_hsa050101.05571875
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04825909
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02944106
46Pyrimidine metabolism_Homo sapiens_hsa002401.01728831
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01090020
48Purine metabolism_Homo sapiens_hsa002300.98878226
49Olfactory transduction_Homo sapiens_hsa047400.98349763
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.95137983
51Retinol metabolism_Homo sapiens_hsa008300.93832453
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93486424
53Nucleotide excision repair_Homo sapiens_hsa034200.92910316
54Nicotine addiction_Homo sapiens_hsa050330.91967572
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.87322219
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86020111
57Fatty acid degradation_Homo sapiens_hsa000710.85888141
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85806024
59Collecting duct acid secretion_Homo sapiens_hsa049660.85542908
60beta-Alanine metabolism_Homo sapiens_hsa004100.84499636
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84376417
62Cardiac muscle contraction_Homo sapiens_hsa042600.81962999
63Metabolic pathways_Homo sapiens_hsa011000.81773585
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80380123
65RNA transport_Homo sapiens_hsa030130.79102711
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78441897
67Sulfur metabolism_Homo sapiens_hsa009200.78060938
68Primary immunodeficiency_Homo sapiens_hsa053400.76475631
69Taste transduction_Homo sapiens_hsa047420.75592389
70Arachidonic acid metabolism_Homo sapiens_hsa005900.74034775
71Sphingolipid metabolism_Homo sapiens_hsa006000.68486655
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66765342
73Asthma_Homo sapiens_hsa053100.64693434
74Vitamin digestion and absorption_Homo sapiens_hsa049770.62466133
75Fatty acid metabolism_Homo sapiens_hsa012120.61803698
76Glycerolipid metabolism_Homo sapiens_hsa005610.59208140
77Insulin secretion_Homo sapiens_hsa049110.58729483
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58194339
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57878663
80ABC transporters_Homo sapiens_hsa020100.57342524
81Steroid biosynthesis_Homo sapiens_hsa001000.56932490
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56196313
83Mineral absorption_Homo sapiens_hsa049780.55037434
84DNA replication_Homo sapiens_hsa030300.54655592
85Type I diabetes mellitus_Homo sapiens_hsa049400.51967525
86Base excision repair_Homo sapiens_hsa034100.51601332
87Morphine addiction_Homo sapiens_hsa050320.50917954
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.50642426
89Folate biosynthesis_Homo sapiens_hsa007900.48388030
90Glutathione metabolism_Homo sapiens_hsa004800.48344668
91Fat digestion and absorption_Homo sapiens_hsa049750.46070841
92Spliceosome_Homo sapiens_hsa030400.46031640
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44308698
94Pyruvate metabolism_Homo sapiens_hsa006200.42339101
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41929331
96Histidine metabolism_Homo sapiens_hsa003400.41327147
97Circadian rhythm_Homo sapiens_hsa047100.38258241
98Serotonergic synapse_Homo sapiens_hsa047260.37427139
99Ovarian steroidogenesis_Homo sapiens_hsa049130.37002311
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35951748

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