ZNF687

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.68312463
2regulation of chromatin binding (GO:0035561)4.57848850
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.46246631
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.95753065
5positive regulation of gamma-delta T cell activation (GO:0046645)3.91234933
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83174940
7positive regulation by organism of defense response of other organism involved in symbiotic interact3.83174940
8modulation by symbiont of host immune response (GO:0052553)3.83174940
9positive regulation by symbiont of host defense response (GO:0052509)3.83174940
10modulation by symbiont of host defense response (GO:0052031)3.83174940
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83174940
12response to peptidoglycan (GO:0032494)3.72899269
13intracellular estrogen receptor signaling pathway (GO:0030520)3.71329933
14regulation of interferon-beta biosynthetic process (GO:0045357)3.60787960
15regulation of gamma-delta T cell activation (GO:0046643)3.58551465
16regulation of gamma-delta T cell differentiation (GO:0045586)3.52877698
17histone H3-K36 demethylation (GO:0070544)3.52633123
18cellular response to virus (GO:0098586)3.50512574
19mannose metabolic process (GO:0006013)3.49190714
20response to muramyl dipeptide (GO:0032495)3.48748758
21thymic T cell selection (GO:0045061)3.45152301
22negative regulation of cell killing (GO:0031342)3.42287463
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42287463
243-UTR-mediated mRNA stabilization (GO:0070935)3.41545448
25regulation of histone H3-K27 methylation (GO:0061085)3.34762272
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.23253137
27negative regulation of viral release from host cell (GO:1902187)3.20796115
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17433599
29positive thymic T cell selection (GO:0045059)3.17181325
30apoptotic process involved in morphogenesis (GO:0060561)3.13357198
31antigen processing and presentation of endogenous antigen (GO:0019883)3.09374811
32negative regulation of histone methylation (GO:0031061)2.98821347
33GDP-mannose metabolic process (GO:0019673)2.96425001
34positive regulation of histone deacetylation (GO:0031065)2.93027023
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92516368
36modulation by virus of host process (GO:0019054)2.88547452
37regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87901609
38positive regulation of interferon-alpha production (GO:0032727)2.87888198
39NIK/NF-kappaB signaling (GO:0038061)2.86689449
40macrophage activation involved in immune response (GO:0002281)2.83956107
41detection of bacterium (GO:0016045)2.75436935
42positive regulation of Cdc42 GTPase activity (GO:0043089)2.74515029
43T cell selection (GO:0045058)2.74196815
44positive regulation of keratinocyte differentiation (GO:0045618)2.71821107
45activation of Rac GTPase activity (GO:0032863)2.71784260
46embryonic process involved in female pregnancy (GO:0060136)2.71341154
47regulation of NFAT protein import into nucleus (GO:0051532)2.71002962
48detection of other organism (GO:0098543)2.69207588
49B cell receptor signaling pathway (GO:0050853)2.69154356
50leukocyte aggregation (GO:0070486)2.68449784
51response to host immune response (GO:0052572)2.68110003
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68110003
53spliceosomal tri-snRNP complex assembly (GO:0000244)2.66727792
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65460186
55histone H3-K9 modification (GO:0061647)2.65011412
56response to host (GO:0075136)2.64842242
57response to host defenses (GO:0052200)2.64842242
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64842242
59negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63463674
60snRNA metabolic process (GO:0016073)2.59947502
61regulation of interferon-alpha production (GO:0032647)2.59103647
62epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57742688
63nucleosome disassembly (GO:0006337)2.57112385
64protein-DNA complex disassembly (GO:0032986)2.57112385
65cellular response to interleukin-4 (GO:0071353)2.56299128
66negative regulation of cell size (GO:0045792)2.55360683
67mRNA stabilization (GO:0048255)2.54562607
68RNA stabilization (GO:0043489)2.54562607
69regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54428383
70trophectodermal cell differentiation (GO:0001829)2.54119688
71positive regulation of gene expression, epigenetic (GO:0045815)2.53405377
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52868981
73cell-substrate adherens junction assembly (GO:0007045)2.52630784
74focal adhesion assembly (GO:0048041)2.52630784
75G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.52417747
76modulation by symbiont of host cellular process (GO:0044068)2.52370822
77CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.51298665
78negative thymic T cell selection (GO:0045060)2.48134363
79peptidyl-arginine omega-N-methylation (GO:0035247)2.46544162
80positive regulation by host of viral transcription (GO:0043923)2.46321649
81amyloid precursor protein catabolic process (GO:0042987)2.45785141
82histone H3-K4 methylation (GO:0051568)2.45695969
83histone H4 deacetylation (GO:0070933)2.44824538
84regulation of interferon-beta production (GO:0032648)2.44200087
85mucosal-associated lymphoid tissue development (GO:0048537)2.42925164
86Peyers patch development (GO:0048541)2.42925164
87immunoglobulin mediated immune response (GO:0016064)2.42225394
88regulation of fatty acid beta-oxidation (GO:0031998)2.39231841
89regulation of histone H3-K4 methylation (GO:0051569)2.38396629
90positive regulation of interferon-beta production (GO:0032728)2.37514807
91positive regulation of protein homooligomerization (GO:0032464)2.37473835
92adherens junction assembly (GO:0034333)2.37006457
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36121961
94germinal center formation (GO:0002467)2.35785148
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.35623154
96heterochromatin organization (GO:0070828)2.35502304
97interferon-gamma secretion (GO:0072643)2.34167912
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.33991199
99ear development (GO:0043583)2.33847860
100B cell homeostasis (GO:0001782)2.33505798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.71112563
2MYC_22102868_ChIP-Seq_BL_Human3.64457332
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76779026
4LXR_22292898_ChIP-Seq_THP-1_Human2.54698372
5* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.48343534
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45060861
7TCF7_22412390_ChIP-Seq_EML_Mouse2.39762456
8* KDM2B_26808549_Chip-Seq_DND41_Human2.28813824
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.24672591
10* VDR_24763502_ChIP-Seq_THP-1_Human2.13825860
11* MAF_26560356_Chip-Seq_TH1_Human2.10823934
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.09732995
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97812061
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92154497
15* MAF_26560356_Chip-Seq_TH2_Human1.90956096
16* UTX_26944678_Chip-Seq_JUKART_Human1.90627333
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86421773
18P68_20966046_ChIP-Seq_HELA_Human1.84829361
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82677422
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77014252
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68922136
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68224186
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.54714676
24* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52655296
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.52436597
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.52134358
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.51560792
28* E2F7_22180533_ChIP-Seq_HELA_Human1.51357115
29SCL_19346495_ChIP-Seq_HPC-7_Human1.50768209
30KDM2B_26808549_Chip-Seq_K562_Human1.50609791
31SA1_27219007_Chip-Seq_ERYTHROID_Human1.48123444
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46307043
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46232621
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46127877
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45014945
36* CREB1_26743006_Chip-Seq_LNCaP_Human1.44908548
37* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43560918
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43463202
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.42170575
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42143828
41CIITA_25753668_ChIP-Seq_RAJI_Human1.41869881
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41515243
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.41239843
44* XRN2_22483619_ChIP-Seq_HELA_Human1.40103170
45BCOR_27268052_Chip-Seq_Bcells_Human1.39357916
46SMC4_20622854_ChIP-Seq_HELA_Human1.39187773
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38787867
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38688385
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.38444809
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36694114
51* RUNX1_27514584_Chip-Seq_MCF-7_Human1.33778165
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32843469
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31334699
54NCOR1_26117541_ChIP-Seq_K562_Human1.30613348
55PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26517403
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.26261229
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25733557
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25227946
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24258349
60BCL6_27268052_Chip-Seq_Bcells_Human1.23629687
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.22830768
62* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21360441
63ZNF263_19887448_ChIP-Seq_K562_Human1.21157646
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20246234
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19612725
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19409101
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18627091
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18551566
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18048836
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17910839
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17791939
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13057342
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12084287
74MYB_26560356_Chip-Seq_TH1_Human1.10546456
75E2F1_20622854_ChIP-Seq_HELA_Human1.10471597
76* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10217754
77* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09651994
78PHF8_20622854_ChIP-Seq_HELA_Human1.09419996
79* CTCF_21964334_Chip-Seq_Bcells_Human1.09044478
80TP53_22127205_ChIP-Seq_IMR90_Human1.08282074
81KDM5A_27292631_Chip-Seq_BREAST_Human1.07777326
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.07688036
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07674512
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07567389
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07316052
86* ATF3_27146783_Chip-Seq_COLON_Human1.07222468
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07118004
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07046514
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06979402
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.06846308
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.06455232
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05698736
93* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04903944
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04122600
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03217604
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02056611
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01883313
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01780060
99SPI1_23547873_ChIP-Seq_NB4_Human1.01478293
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00920900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.79631474
2MP0009278_abnormal_bone_marrow3.41160238
3MP0003436_decreased_susceptibility_to2.75385526
4MP0003705_abnormal_hypodermis_morpholog2.67445537
5MP0002254_reproductive_system_inflammat2.49102200
6MP0002396_abnormal_hematopoietic_system2.39087071
7MP0004381_abnormal_hair_follicle2.36929402
8MP0003303_peritoneal_inflammation2.36188629
9MP0003763_abnormal_thymus_physiology2.32627828
10MP0005451_abnormal_body_composition2.19189065
11MP0004185_abnormal_adipocyte_glucose2.18553372
12MP0000685_abnormal_immune_system2.03239406
13MP0009333_abnormal_splenocyte_physiolog2.03161105
14MP0003172_abnormal_lysosome_physiology1.98920582
15MP0001873_stomach_inflammation1.88590929
16MP0005083_abnormal_biliary_tract1.86373335
17MP0001800_abnormal_humoral_immune1.85224374
18MP0004264_abnormal_extraembryonic_tissu1.83193515
19MP0001348_abnormal_lacrimal_gland1.80750371
20MP0002398_abnormal_bone_marrow1.74209070
21MP0005025_abnormal_response_to1.72727097
22MP0004858_abnormal_nervous_system1.72446304
23MP0001835_abnormal_antigen_presentation1.70829872
24MP0005671_abnormal_response_to1.69348109
25MP0003111_abnormal_nucleus_morphology1.67549796
26MP0001849_ear_inflammation1.66793841
27MP0005058_abnormal_lysosome_morphology1.66657389
28MP0005000_abnormal_immune_tolerance1.64664435
29MP0002420_abnormal_adaptive_immunity1.64314766
30MP0001819_abnormal_immune_cell1.64307823
31MP0004233_abnormal_muscle_weight1.64235578
32MP0000703_abnormal_thymus_morphology1.63822781
33MP0002723_abnormal_immune_serum1.62795038
34MP0003453_abnormal_keratinocyte_physiol1.62658070
35MP0004947_skin_inflammation1.61641133
36MP0008260_abnormal_autophagy1.61195534
37MP0002452_abnormal_antigen_presenting1.59327672
38MP0002419_abnormal_innate_immunity1.58133256
39MP0001790_abnormal_immune_system1.56918639
40MP0005387_immune_system_phenotype1.56918639
41MP0000716_abnormal_immune_system1.51523611
42MP0009840_abnormal_foam_cell1.48464540
43MP0004808_abnormal_hematopoietic_stem1.48266530
44MP0002009_preneoplasia1.46122559
45MP0002249_abnormal_larynx_morphology1.43927854
46MP0002722_abnormal_immune_system1.42652352
47MP0003183_abnormal_peptide_metabolism1.42631707
48MP0002429_abnormal_blood_cell1.41678719
49MP0002796_impaired_skin_barrier1.39421519
50MP0003693_abnormal_embryo_hatching1.35727965
51MP0005397_hematopoietic_system_phenotyp1.33845847
52MP0001545_abnormal_hematopoietic_system1.33845847
53MP0005501_abnormal_skin_physiology1.32235629
54MP0000689_abnormal_spleen_morphology1.31177367
55MP0005409_darkened_coat_color1.26316788
56MP0005310_abnormal_salivary_gland1.19343475
57MP0005666_abnormal_adipose_tissue1.17270795
58MP0009672_abnormal_birth_weight1.17238107
59MP0000490_abnormal_crypts_of1.16321212
60MP0002089_abnormal_postnatal_growth/wei1.15940147
61MP0002166_altered_tumor_susceptibility1.15458404
62MP0003077_abnormal_cell_cycle1.10965571
63MP0000678_abnormal_parathyroid_gland1.09410873
64MP0005377_hearing/vestibular/ear_phenot1.08711533
65MP0003878_abnormal_ear_physiology1.08711533
66MP0002405_respiratory_system_inflammati1.08136959
67MP0002148_abnormal_hypersensitivity_rea1.07736457
68MP0010155_abnormal_intestine_physiology1.07086692
69MP0008961_abnormal_basal_metabolism1.06466235
70MP0008057_abnormal_DNA_replication1.05552964
71MP0002019_abnormal_tumor_incidence1.05457237
72MP0003866_abnormal_defecation1.05296887
73MP0005375_adipose_tissue_phenotype1.04829587
74MP0009931_abnormal_skin_appearance1.02759976
75MP0001346_abnormal_lacrimal_gland1.01810299
76MP0000858_altered_metastatic_potential1.01100573
77MP0000350_abnormal_cell_proliferation0.98094071
78MP0000313_abnormal_cell_death0.97860955
79MP0001533_abnormal_skeleton_physiology0.95675922
80MP0000470_abnormal_stomach_morphology0.91897687
81MP0003191_abnormal_cellular_cholesterol0.91847914
82MP0005621_abnormal_cell_physiology0.90458717
83MP0010094_abnormal_chromosome_stability0.89218349
84MP0000003_abnormal_adipose_tissue0.88969437
85MP0002098_abnormal_vibrissa_morphology0.88846698
86MP0009785_altered_susceptibility_to0.88254469
87MP0002998_abnormal_bone_remodeling0.86801593
88MP0003300_gastrointestinal_ulcer0.86270333
89MP0001845_abnormal_inflammatory_respons0.83484705
90MP0005174_abnormal_tail_pigmentation0.80615242
91MP0000477_abnormal_intestine_morphology0.77581127
92MP0005075_abnormal_melanosome_morpholog0.76461441
93MP0001730_embryonic_growth_arrest0.74847593
94MP0008469_abnormal_protein_level0.74290925
95MP0003091_abnormal_cell_migration0.74265579
96MP0000750_abnormal_muscle_regeneration0.72248826
97MP0004197_abnormal_fetal_growth/weight/0.72143012
98MP0002080_prenatal_lethality0.71750272
99MP0000377_abnormal_hair_follicle0.71537095
100MP0003984_embryonic_growth_retardation0.71215055

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.51995785
2Abnormality of the fingertips (HP:0001211)3.49359564
3Increased neuronal autofluorescent lipopigment (HP:0002074)3.34317902
4Eczematoid dermatitis (HP:0000976)3.28934403
5Increased cerebral lipofuscin (HP:0011813)3.19251620
6Colitis (HP:0002583)3.12941352
7Thin bony cortex (HP:0002753)2.95852196
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94270737
9Cellulitis (HP:0100658)2.79072487
10Recurrent cutaneous fungal infections (HP:0011370)2.72127809
11Chronic mucocutaneous candidiasis (HP:0002728)2.72127809
12Recurrent bacterial skin infections (HP:0005406)2.71400752
13Recurrent abscess formation (HP:0002722)2.66227366
14Testicular atrophy (HP:0000029)2.64941695
15Gastrointestinal inflammation (HP:0004386)2.60852042
16Recurrent fungal infections (HP:0002841)2.57964731
17Mediastinal lymphadenopathy (HP:0100721)2.56009546
18Asymmetry of the thorax (HP:0001555)2.52121067
19Meningitis (HP:0001287)2.46899720
20Poikiloderma (HP:0001029)2.44533106
21Intestinal fistula (HP:0100819)2.44477932
22Broad face (HP:0000283)2.44464281
23Agammaglobulinemia (HP:0004432)2.43851306
24Ulnar bowing (HP:0003031)2.43619544
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42182522
26Septate vagina (HP:0001153)2.41836167
27Myositis (HP:0100614)2.41253586
28Hemorrhage of the eye (HP:0011885)2.37691135
29Progressive muscle weakness (HP:0003323)2.32398126
30Squamous cell carcinoma (HP:0002860)2.31952684
31Inflammation of the large intestine (HP:0002037)2.29789511
32J-shaped sella turcica (HP:0002680)2.29609806
33Abnormality of macrophages (HP:0004311)2.28922821
34Increased IgE level (HP:0003212)2.28134979
35Annular pancreas (HP:0001734)2.28102707
36Obstructive sleep apnea (HP:0002870)2.27929618
37Orchitis (HP:0100796)2.24403902
38Germ cell neoplasia (HP:0100728)2.22870382
39Easy fatigability (HP:0003388)2.22139605
40Hypochromic anemia (HP:0001931)2.21384549
41Abnormality of the thoracic spine (HP:0100711)2.20439292
42Long palpebral fissure (HP:0000637)2.13660774
43Abnormality of the columella (HP:0009929)2.13625050
44Recurrent skin infections (HP:0001581)2.10590635
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.08579726
46Vaginal fistula (HP:0004320)2.04563450
47Recurrent viral infections (HP:0004429)2.04266252
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.02014223
49Deformed sella turcica (HP:0002681)2.00406043
50Gastrointestinal infarctions (HP:0005244)1.99775448
51Spinal cord lesions (HP:0100561)1.98932232
52Syringomyelia (HP:0003396)1.98932232
53Flat acetabular roof (HP:0003180)1.97721273
54Gastrointestinal stroma tumor (HP:0100723)1.93322012
55Obstructive lung disease (HP:0006536)1.90533368
56Chronic obstructive pulmonary disease (HP:0006510)1.90533368
57Micronodular cirrhosis (HP:0001413)1.90293412
58Elevated erythrocyte sedimentation rate (HP:0003565)1.89129009
59Patellar aplasia (HP:0006443)1.88906478
60Spina bifida occulta (HP:0003298)1.86873712
61Sparse lateral eyebrow (HP:0005338)1.86174695
62Rib fusion (HP:0000902)1.83420233
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83168180
64Long eyelashes (HP:0000527)1.82095404
65Acute lymphatic leukemia (HP:0006721)1.80885477
66Hypertensive crisis (HP:0100735)1.80524984
67Basal cell carcinoma (HP:0002671)1.80460518
68Viral hepatitis (HP:0006562)1.79942011
69Nasolacrimal duct obstruction (HP:0000579)1.78273202
70Thoracic kyphosis (HP:0002942)1.78152014
71Increased serum ferritin (HP:0003281)1.76611956
72Retrobulbar optic neuritis (HP:0100654)1.76252424
73Optic neuritis (HP:0100653)1.76252424
74Capillary hemangiomas (HP:0005306)1.74510408
75Breast hypoplasia (HP:0003187)1.73759230
76Birth length less than 3rd percentile (HP:0003561)1.73540806
77Panhypogammaglobulinemia (HP:0003139)1.72316902
78Supernumerary nipples (HP:0002558)1.72254998
79Turricephaly (HP:0000262)1.71944773
80Rectovaginal fistula (HP:0000143)1.71626662
81Rectal fistula (HP:0100590)1.71626662
82Slow saccadic eye movements (HP:0000514)1.70733257
83Emphysema (HP:0002097)1.70179428
84Self-mutilation (HP:0000742)1.69795048
85Dysmetric saccades (HP:0000641)1.69773210
86Patellar dislocation (HP:0002999)1.69507024
87Aplasia/Hypoplasia of the patella (HP:0006498)1.69126527
88Progressive external ophthalmoplegia (HP:0000590)1.68261369
89Centrally nucleated skeletal muscle fibers (HP:0003687)1.67456457
90Pointed chin (HP:0000307)1.66489750
91Abnormality of the radial head (HP:0003995)1.65655251
92Selective tooth agenesis (HP:0001592)1.65598402
93Reticulocytosis (HP:0001923)1.65243334
94Hypercortisolism (HP:0001578)1.63547727
95Deep palmar crease (HP:0006191)1.62859720
96Vasculitis (HP:0002633)1.62806453
97Arterial thrombosis (HP:0004420)1.62086030
98Persistence of primary teeth (HP:0006335)1.60461959
99Metaphyseal cupping (HP:0003021)1.60233947
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56839720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.22604035
2SMG13.46747439
3SIK13.41295774
4ERN13.29335438
5EEF2K3.05529962
6CDK122.94015266
7PRPF4B2.91808294
8MAP4K12.59814688
9ICK2.22810889
10MAP3K102.19154723
11IRAK41.84950489
12TESK21.82960810
13IRAK31.78842957
14FGFR41.77824317
15PKN21.68393555
16MAP2K31.64734815
17GRK61.63222978
18SIK21.56125651
19RIPK41.55634634
20TBK11.38569147
21PRKD21.38196283
22RIPK11.32329072
23MAP2K21.28953028
24TAOK11.27182695
25TNK21.24311441
26BLK1.24132931
27MTOR1.20183731
28MARK21.19436908
29PTK61.18775923
30MAP3K111.14726282
31IKBKE1.14015170
32CAMK1D1.13490323
33IRAK21.12990405
34MUSK1.12928692
35RPS6KB21.10801485
36BRD41.01912453
37SIK31.00993249
38CHUK1.00706536
39EPHA20.98665103
40TYK20.98020207
41MAPK110.94414530
42EPHB10.93164306
43NME20.93033458
44RPS6KC10.91827810
45RPS6KL10.91827810
46MAP3K130.90733540
47MAP3K10.89742693
48ZAP700.89233665
49MAP3K140.88325897
50MAPK150.86718839
51RPS6KA20.86315063
52HIPK20.85303920
53CDK40.84902421
54BTK0.84245698
55IKBKB0.83077715
56RPS6KA60.82774945
57PDPK10.82321348
58TLK10.82077837
59TAOK20.78795654
60CDK70.77259747
61CSK0.74825480
62BMX0.69389537
63CSF1R0.68880873
64DYRK1B0.67350923
65HCK0.64183169
66CDC42BPA0.61238686
67MAP3K30.61198490
68RPS6KA10.61128284
69JAK30.61046114
70MAP3K70.61023429
71IRAK10.59759629
72KSR20.58806107
73PIM10.57880239
74MAPK120.57737714
75NME10.55907686
76PDK10.55170688
77FES0.54106121
78PIM20.52362412
79VRK20.50103999
80TTN0.49695936
81MAPKAPK30.46120443
82TYRO30.44817790
83MATK0.44020881
84MAPK70.44014966
85CAMK1G0.43130251
86MAPKAPK20.42918200
87MAPK80.41436811
88CAMKK10.41363415
89ALK0.39644172
90RET0.39461989
91LRRK20.38839211
92CHEK20.38621624
93SYK0.37633275
94PRKCI0.36261927
95ITK0.35626862
96MAP3K80.35309935
97JAK20.33926854
98MAPK30.33753491
99LYN0.33547136
100LCK0.33422252

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.69654540
2B cell receptor signaling pathway_Homo sapiens_hsa046622.43916427
3Non-small cell lung cancer_Homo sapiens_hsa052232.12971505
4Notch signaling pathway_Homo sapiens_hsa043302.06945436
5Other glycan degradation_Homo sapiens_hsa005111.98098435
6Chronic myeloid leukemia_Homo sapiens_hsa052201.96947606
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.87953586
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86027420
9Primary immunodeficiency_Homo sapiens_hsa053401.81088436
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80690236
11VEGF signaling pathway_Homo sapiens_hsa043701.68703725
12Osteoclast differentiation_Homo sapiens_hsa043801.65356436
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60548799
14Endometrial cancer_Homo sapiens_hsa052131.57851958
15Bladder cancer_Homo sapiens_hsa052191.55690186
16Hepatitis C_Homo sapiens_hsa051601.49598516
17Leishmaniasis_Homo sapiens_hsa051401.45336501
18Sulfur relay system_Homo sapiens_hsa041221.44976288
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.43436204
20Hepatitis B_Homo sapiens_hsa051611.42111370
21T cell receptor signaling pathway_Homo sapiens_hsa046601.41361901
22Influenza A_Homo sapiens_hsa051641.35805341
23Pancreatic cancer_Homo sapiens_hsa052121.35207373
24Viral carcinogenesis_Homo sapiens_hsa052031.33396037
25mTOR signaling pathway_Homo sapiens_hsa041501.32727942
26Measles_Homo sapiens_hsa051621.31591945
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.30663110
28Thyroid cancer_Homo sapiens_hsa052161.30399467
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.29980527
30Herpes simplex infection_Homo sapiens_hsa051681.28628897
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28215089
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27648250
33Fructose and mannose metabolism_Homo sapiens_hsa000511.25719330
34Base excision repair_Homo sapiens_hsa034101.23556052
35Apoptosis_Homo sapiens_hsa042101.21399435
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16941425
37Inositol phosphate metabolism_Homo sapiens_hsa005621.15451952
38Renal cell carcinoma_Homo sapiens_hsa052111.15192082
39TNF signaling pathway_Homo sapiens_hsa046681.11655117
40Prolactin signaling pathway_Homo sapiens_hsa049171.11395173
41Lysine degradation_Homo sapiens_hsa003101.10242288
42Prostate cancer_Homo sapiens_hsa052151.08690539
43ErbB signaling pathway_Homo sapiens_hsa040121.07417376
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.06169297
45Systemic lupus erythematosus_Homo sapiens_hsa053221.06009904
46Colorectal cancer_Homo sapiens_hsa052101.05216141
47Insulin resistance_Homo sapiens_hsa049311.04667760
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02887219
49Epstein-Barr virus infection_Homo sapiens_hsa051691.02820706
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01563087
51DNA replication_Homo sapiens_hsa030301.00511196
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99889374
53HTLV-I infection_Homo sapiens_hsa051660.99864267
54Tuberculosis_Homo sapiens_hsa051520.99516991
55Choline metabolism in cancer_Homo sapiens_hsa052310.96970435
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96303518
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.95993284
58Insulin signaling pathway_Homo sapiens_hsa049100.94280886
59Toxoplasmosis_Homo sapiens_hsa051450.94256672
60MicroRNAs in cancer_Homo sapiens_hsa052060.89893052
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88602088
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.87378975
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.86896867
64Pentose phosphate pathway_Homo sapiens_hsa000300.86460991
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.85858155
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84249834
67Small cell lung cancer_Homo sapiens_hsa052220.84101433
68Chemokine signaling pathway_Homo sapiens_hsa040620.82724003
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.81618699
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80640400
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80066287
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79875958
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78564829
74AMPK signaling pathway_Homo sapiens_hsa041520.78391670
75Glioma_Homo sapiens_hsa052140.78114379
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.77992070
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.76091623
78FoxO signaling pathway_Homo sapiens_hsa040680.75843813
79Allograft rejection_Homo sapiens_hsa053300.71488990
80Graft-versus-host disease_Homo sapiens_hsa053320.70775510
81Estrogen signaling pathway_Homo sapiens_hsa049150.69918932
82Lysosome_Homo sapiens_hsa041420.69821986
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67761198
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64617387
85Alcoholism_Homo sapiens_hsa050340.63814235
86Spliceosome_Homo sapiens_hsa030400.63477125
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63220237
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63214883
89Autoimmune thyroid disease_Homo sapiens_hsa053200.63122559
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60532118
91GnRH signaling pathway_Homo sapiens_hsa049120.58679103
92mRNA surveillance pathway_Homo sapiens_hsa030150.57938791
93MAPK signaling pathway_Homo sapiens_hsa040100.57300422
94HIF-1 signaling pathway_Homo sapiens_hsa040660.56110234
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56002594
96Staphylococcus aureus infection_Homo sapiens_hsa051500.55230098
97Platelet activation_Homo sapiens_hsa046110.54696441
98Viral myocarditis_Homo sapiens_hsa054160.50918165
99Type II diabetes mellitus_Homo sapiens_hsa049300.46816899
100Endocytosis_Homo sapiens_hsa041440.45477100

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