ZNF689

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)5.53663404
2chromatin remodeling at centromere (GO:0031055)4.28463818
3DNA strand elongation involved in DNA replication (GO:0006271)4.27848578
4CENP-A containing nucleosome assembly (GO:0034080)4.17126905
5DNA strand elongation (GO:0022616)4.14877571
6telomere maintenance via semi-conservative replication (GO:0032201)4.00790796
7maturation of SSU-rRNA (GO:0030490)3.97755460
8DNA replication-dependent nucleosome assembly (GO:0006335)3.82284815
9DNA replication-dependent nucleosome organization (GO:0034723)3.82284815
10mitotic metaphase plate congression (GO:0007080)3.75713432
11replication fork processing (GO:0031297)3.66106888
12somatic hypermutation of immunoglobulin genes (GO:0016446)3.66106085
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.66106085
14histone exchange (GO:0043486)3.50685245
15protein localization to chromosome, centromeric region (GO:0071459)3.48036702
16DNA replication-independent nucleosome assembly (GO:0006336)3.47950173
17DNA replication-independent nucleosome organization (GO:0034724)3.47950173
18protein localization to kinetochore (GO:0034501)3.47046511
19translesion synthesis (GO:0019985)3.43188189
20telomere maintenance via recombination (GO:0000722)3.43134723
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38998130
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38998130
23positive regulation of mitotic sister chromatid separation (GO:1901970)3.38998130
24DNA double-strand break processing (GO:0000729)3.35189129
25DNA strand renaturation (GO:0000733)3.29516803
26mitotic chromosome condensation (GO:0007076)3.25145004
27telomere maintenance via telomere lengthening (GO:0010833)3.23501544
28mitotic recombination (GO:0006312)3.21907120
29resolution of meiotic recombination intermediates (GO:0000712)3.21871798
30positive regulation of chromosome segregation (GO:0051984)3.21760882
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.21361225
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20909996
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19262890
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19152534
35cullin deneddylation (GO:0010388)3.16442551
36negative regulation of chromosome segregation (GO:0051985)3.15106620
37spindle checkpoint (GO:0031577)3.14703254
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14571206
39regulation of mitotic spindle checkpoint (GO:1903504)3.14571206
40regulation of helicase activity (GO:0051095)3.12700669
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.12313265
42attachment of spindle microtubules to kinetochore (GO:0008608)3.10692754
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10608522
44negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09764986
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.09764986
46negative regulation of sister chromatid segregation (GO:0033046)3.09764986
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09764986
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09764986
49protein deneddylation (GO:0000338)3.09423275
50mitotic spindle checkpoint (GO:0071174)3.07692355
51metaphase plate congression (GO:0051310)3.07116275
52postreplication repair (GO:0006301)3.06336718
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05197572
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05197572
55DNA damage response, detection of DNA damage (GO:0042769)3.04630188
56chaperone-mediated protein transport (GO:0072321)3.03271963
57regulation of mitotic sister chromatid separation (GO:0010965)3.02389234
58regulation of mitotic sister chromatid segregation (GO:0033047)3.02389234
59regulation of sister chromatid segregation (GO:0033045)3.02389234
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.01126345
61proteasome assembly (GO:0043248)3.00183022
62mitotic sister chromatid segregation (GO:0000070)3.00007969
63establishment of protein localization to mitochondrial membrane (GO:0090151)2.99936384
64mitotic sister chromatid cohesion (GO:0007064)2.98138218
65centriole replication (GO:0007099)2.97509192
66DNA replication initiation (GO:0006270)2.97236413
67DNA catabolic process, exonucleolytic (GO:0000738)2.96273928
68DNA ligation (GO:0006266)2.92199637
69regulation of double-strand break repair via homologous recombination (GO:0010569)2.91600770
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90769623
71negative regulation of mRNA processing (GO:0050686)2.90662784
72mitotic spindle assembly checkpoint (GO:0007094)2.87702443
73intra-S DNA damage checkpoint (GO:0031573)2.87501972
74mitotic nuclear envelope disassembly (GO:0007077)2.87335619
75regulation of chromatin binding (GO:0035561)2.86269224
76spliceosomal snRNP assembly (GO:0000387)2.86006568
77spindle assembly checkpoint (GO:0071173)2.85968697
78chromatin assembly or disassembly (GO:0006333)2.85804551
79rRNA modification (GO:0000154)2.84740507
80double-strand break repair via nonhomologous end joining (GO:0006303)2.83793157
81non-recombinational repair (GO:0000726)2.83793157
82mitochondrial RNA metabolic process (GO:0000959)2.83303192
83regulation of chromosome segregation (GO:0051983)2.83267502
84kinetochore assembly (GO:0051382)2.82110562
85rRNA processing (GO:0006364)2.80790562
86mismatch repair (GO:0006298)2.80650379
87kinetochore organization (GO:0051383)2.78098458
88single strand break repair (GO:0000012)2.77557239
89recombinational repair (GO:0000725)2.75224949
90sister chromatid segregation (GO:0000819)2.74424586
91double-strand break repair via homologous recombination (GO:0000724)2.73598776
92establishment of integrated proviral latency (GO:0075713)2.73028078
93ATP-dependent chromatin remodeling (GO:0043044)2.72970826
94negative regulation of RNA splicing (GO:0033119)2.71573128
95termination of RNA polymerase III transcription (GO:0006386)2.70897632
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.70897632
97protein localization to chromosome (GO:0034502)2.70518947
98regulation of meiosis I (GO:0060631)2.69860805
99rRNA metabolic process (GO:0016072)2.67962396
100telomere organization (GO:0032200)2.66708219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43839164
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.30183680
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82410709
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.50980678
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.42803765
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.41431435
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26420957
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.24585049
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01221678
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00881773
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.89044108
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.64453192
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61008419
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59761200
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55221805
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54207146
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50297476
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49939940
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46089580
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42491475
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40145385
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.36297531
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31152537
24* TTF2_22483619_ChIP-Seq_HELA_Human2.30621868
25* VDR_23849224_ChIP-Seq_CD4+_Human2.30257824
26* XRN2_22483619_ChIP-Seq_HELA_Human2.29321980
27FOXP3_21729870_ChIP-Seq_TREG_Human2.26892135
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12754190
29GABP_19822575_ChIP-Seq_HepG2_Human2.12395935
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.03868134
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99165147
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97620555
33DCP1A_22483619_ChIP-Seq_HELA_Human1.93933005
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87090577
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86062254
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85465902
37MYC_18940864_ChIP-ChIP_HL60_Human1.80110235
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.79251162
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78764586
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75176758
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74214844
42KDM5A_27292631_Chip-Seq_BREAST_Human1.67690194
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67149042
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67063578
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.66373037
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65739683
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63160707
48ZNF274_21170338_ChIP-Seq_K562_Hela1.62892850
49ELK1_19687146_ChIP-ChIP_HELA_Human1.62246659
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61958038
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57512675
52AR_21909140_ChIP-Seq_LNCAP_Human1.56279862
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55165865
54EZH2_22144423_ChIP-Seq_EOC_Human1.52605853
55* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.50750389
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48418634
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45614759
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45605640
59EWS_26573619_Chip-Seq_HEK293_Human1.43590505
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.40061741
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39779280
62IRF1_19129219_ChIP-ChIP_H3396_Human1.38634360
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33222332
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31862309
65* CIITA_25753668_ChIP-Seq_RAJI_Human1.31395058
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30602767
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26304234
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.22965719
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22848234
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22688723
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22572368
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21396970
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16819800
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.16419443
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12057756
76FUS_26573619_Chip-Seq_HEK293_Human1.11704574
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07829089
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07253751
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01903167
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01000346
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00818181
82TFEB_21752829_ChIP-Seq_HELA_Human0.98401107
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97609230
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96769855
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.95838828
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91487871
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85459758
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85077632
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83079335
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82724116
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80502412
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78797036
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76861678
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76418051
95TP53_22573176_ChIP-Seq_HFKS_Human0.75700563
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.74241060
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.73119257
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72146500
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72079734
100IGF1R_20145208_ChIP-Seq_DFB_Human0.69315724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.56978830
2MP0003693_abnormal_embryo_hatching4.54668999
3MP0008058_abnormal_DNA_repair4.09383609
4MP0010094_abnormal_chromosome_stability4.00378006
5MP0006292_abnormal_olfactory_placode3.67761255
6MP0003111_abnormal_nucleus_morphology3.65632091
7MP0008877_abnormal_DNA_methylation3.20801314
8MP0003077_abnormal_cell_cycle2.93519729
9MP0004957_abnormal_blastocyst_morpholog2.74499603
10MP0003718_maternal_effect2.56232035
11MP0008789_abnormal_olfactory_epithelium2.38099543
12MP0008932_abnormal_embryonic_tissue2.24790069
13MP0005394_taste/olfaction_phenotype2.12901385
14MP0005499_abnormal_olfactory_system2.12901385
15MP0001293_anophthalmia1.85013989
16MP0010030_abnormal_orbit_morphology1.84122164
17MP0008007_abnormal_cellular_replicative1.83841346
18MP0001529_abnormal_vocalization1.79899376
19MP0002234_abnormal_pharynx_morphology1.79437595
20MP0003122_maternal_imprinting1.77881829
21MP0003121_genomic_imprinting1.77821633
22MP0001346_abnormal_lacrimal_gland1.75901047
23MP0002160_abnormal_reproductive_system1.73010767
24MP0003890_abnormal_embryonic-extraembry1.69841332
25MP0000049_abnormal_middle_ear1.68026635
26MP0002938_white_spotting1.65008329
27MP0003136_yellow_coat_color1.60917645
28MP0001730_embryonic_growth_arrest1.57303337
29MP0002233_abnormal_nose_morphology1.56871476
30MP0001188_hyperpigmentation1.56803706
31MP0002210_abnormal_sex_determination1.55846188
32MP0001929_abnormal_gametogenesis1.52216295
33MP0002102_abnormal_ear_morphology1.40945532
34MP0003787_abnormal_imprinting1.37050468
35MP0002163_abnormal_gland_morphology1.35591281
36MP0003123_paternal_imprinting1.33426736
37MP0005367_renal/urinary_system_phenotyp1.32914813
38MP0000516_abnormal_urinary_system1.32914813
39MP0000631_abnormal_neuroendocrine_gland1.31425993
40MP0000350_abnormal_cell_proliferation1.30238977
41MP0003937_abnormal_limbs/digits/tail_de1.25820454
42MP0001286_abnormal_eye_development1.20203538
43MP0003880_abnormal_central_pattern1.20179776
44MP0001145_abnormal_male_reproductive1.20051129
45MP0000653_abnormal_sex_gland1.18728499
46MP0006035_abnormal_mitochondrial_morpho1.17543635
47MP0003786_premature_aging1.14518050
48MP0005389_reproductive_system_phenotype1.14021210
49MP0001697_abnormal_embryo_size1.13489704
50MP0000372_irregular_coat_pigmentation1.12648897
51MP0002085_abnormal_embryonic_tissue1.12647132
52MP0005380_embryogenesis_phenotype1.12428262
53MP0001672_abnormal_embryogenesis/_devel1.12428262
54MP0003567_abnormal_fetal_cardiomyocyte1.12078953
55MP0006276_abnormal_autonomic_nervous1.08574754
56MP0009672_abnormal_birth_weight1.05895789
57MP0002249_abnormal_larynx_morphology1.04392948
58MP0001324_abnormal_eye_pigmentation1.03993188
59MP0003698_abnormal_male_reproductive1.03701516
60MP0002084_abnormal_developmental_patter1.02715819
61MP0002735_abnormal_chemical_nociception1.02370975
62MP0002751_abnormal_autonomic_nervous0.97553725
63MP0005075_abnormal_melanosome_morpholog0.96876745
64MP0001919_abnormal_reproductive_system0.94918357
65MP0002697_abnormal_eye_size0.94808519
66MP0003119_abnormal_digestive_system0.94173299
67MP0000313_abnormal_cell_death0.94056549
68MP0002277_abnormal_respiratory_mucosa0.92943825
69MP0005174_abnormal_tail_pigmentation0.91518670
70MP0001984_abnormal_olfaction0.91347438
71MP0006036_abnormal_mitochondrial_physio0.90162400
72MP0002080_prenatal_lethality0.89602921
73MP0003861_abnormal_nervous_system0.89530719
74MP0001119_abnormal_female_reproductive0.88588337
75MP0004197_abnormal_fetal_growth/weight/0.86927992
76MP0003938_abnormal_ear_development0.86737386
77MP0008995_early_reproductive_senescence0.86673597
78MP0003984_embryonic_growth_retardation0.86651912
79MP0002161_abnormal_fertility/fecundity0.84493990
80MP0002088_abnormal_embryonic_growth/wei0.84400156
81MP0006072_abnormal_retinal_apoptosis0.81308963
82MP0000778_abnormal_nervous_system0.78905625
83MP0009379_abnormal_foot_pigmentation0.78433285
84MP0005391_vision/eye_phenotype0.76363140
85MP0002092_abnormal_eye_morphology0.74538787
86MP0004133_heterotaxia0.72939249
87MP0003699_abnormal_female_reproductive0.72755124
88MP0005379_endocrine/exocrine_gland_phen0.72692979
89MP0009703_decreased_birth_body0.72561742
90MP0003755_abnormal_palate_morphology0.71347570
91MP0000358_abnormal_cell_content/0.70251818
92MP0002111_abnormal_tail_morphology0.69284268
93MP0005645_abnormal_hypothalamus_physiol0.68875487
94MP0001986_abnormal_taste_sensitivity0.68404178
95MP0003315_abnormal_perineum_morphology0.65156017
96MP0003935_abnormal_craniofacial_develop0.62474554
97MP0005220_abnormal_exocrine_pancreas0.61369767
98MP0001764_abnormal_homeostasis0.59847297
99MP0005253_abnormal_eye_physiology0.59835192
100MP0005423_abnormal_somatic_nervous0.57686258

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.46589738
2Reticulocytopenia (HP:0001896)4.07060796
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.88855989
4Chromsome breakage (HP:0040012)3.68804110
5Meckel diverticulum (HP:0002245)3.15991689
6Abnormality of the ileum (HP:0001549)3.14828064
7Colon cancer (HP:0003003)3.14225152
8Absent thumb (HP:0009777)3.08635345
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.97536440
10Absent radius (HP:0003974)2.96725010
11Aplasia/Hypoplasia of the sacrum (HP:0008517)2.94281620
12Abnormality of chromosome stability (HP:0003220)2.85118784
13Birth length less than 3rd percentile (HP:0003561)2.79870092
14Absent forearm bone (HP:0003953)2.77832875
15Aplasia involving forearm bones (HP:0009822)2.77832875
16Triphalangeal thumb (HP:0001199)2.76354382
17Impulsivity (HP:0100710)2.75730273
18Ectopic kidney (HP:0000086)2.69917161
19Ependymoma (HP:0002888)2.68972243
20Abnormality of the preputium (HP:0100587)2.64969222
21Microvesicular hepatic steatosis (HP:0001414)2.57017483
22Horseshoe kidney (HP:0000085)2.35804280
23Lipid accumulation in hepatocytes (HP:0006561)2.28983150
24Medulloblastoma (HP:0002885)2.24538518
25Short thumb (HP:0009778)2.22385515
26Patellar aplasia (HP:0006443)2.21390106
27Increased hepatocellular lipid droplets (HP:0006565)2.21062646
28Hyperglycinemia (HP:0002154)2.20255430
29Multiple enchondromatosis (HP:0005701)2.17607147
30Acute necrotizing encephalopathy (HP:0006965)2.14706640
31Sloping forehead (HP:0000340)2.13871604
32Increased CSF lactate (HP:0002490)2.11716933
33Abnormal lung lobation (HP:0002101)2.08809099
34Aplasia/Hypoplasia of the patella (HP:0006498)2.08352065
35High anterior hairline (HP:0009890)2.07411223
36Increased serum lactate (HP:0002151)2.05927249
37Volvulus (HP:0002580)2.05323286
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04314496
39Rectovaginal fistula (HP:0000143)2.04190544
40Rectal fistula (HP:0100590)2.04190544
41Supernumerary spleens (HP:0009799)2.02296379
42Glioma (HP:0009733)1.99611812
43Methylmalonic acidemia (HP:0002912)1.99284748
44Acute encephalopathy (HP:0006846)1.98282568
45Preaxial hand polydactyly (HP:0001177)1.98251418
46Astrocytoma (HP:0009592)1.97528613
47Abnormality of the astrocytes (HP:0100707)1.97528613
48Abnormality of the fetal cardiovascular system (HP:0010948)1.97435569
49Abnormal umbilical cord blood vessels (HP:0011403)1.97435569
50Single umbilical artery (HP:0001195)1.97435569
51Cleft eyelid (HP:0000625)1.95967881
52Facial hemangioma (HP:0000329)1.95786351
53Small intestinal stenosis (HP:0012848)1.93418867
54Duodenal stenosis (HP:0100867)1.93418867
55Mitochondrial inheritance (HP:0001427)1.93369952
56Abnormal mitochondria in muscle tissue (HP:0008316)1.93315366
57Congenital malformation of the right heart (HP:0011723)1.92951289
58Double outlet right ventricle (HP:0001719)1.92951289
59Prominent metopic ridge (HP:0005487)1.91817296
60Carpal bone hypoplasia (HP:0001498)1.91313139
61Abnormality of the metopic suture (HP:0005556)1.91027376
62Retinal dysplasia (HP:0007973)1.90611339
63Abnormality of the duodenum (HP:0002246)1.89460327
64Macrocytic anemia (HP:0001972)1.89180024
65Renal Fanconi syndrome (HP:0001994)1.87205093
66Cortical dysplasia (HP:0002539)1.86458931
67Optic nerve coloboma (HP:0000588)1.85591001
68Broad distal phalanx of finger (HP:0009836)1.85243729
69Abdominal situs inversus (HP:0003363)1.85078409
70Abnormality of abdominal situs (HP:0011620)1.85078409
71Myelodysplasia (HP:0002863)1.84890575
72Abnormality of the carotid arteries (HP:0005344)1.84796197
73Progressive macrocephaly (HP:0004481)1.83729651
74Septo-optic dysplasia (HP:0100842)1.82981764
75Hepatocellular necrosis (HP:0001404)1.82052857
76Intestinal atresia (HP:0011100)1.81893416
77Abnormality of midbrain morphology (HP:0002418)1.81153621
78Molar tooth sign on MRI (HP:0002419)1.81153621
79Shoulder girdle muscle weakness (HP:0003547)1.81125853
80Abnormality of cells of the erythroid lineage (HP:0012130)1.80490862
81Esophageal atresia (HP:0002032)1.79611662
82Failure to thrive in infancy (HP:0001531)1.77055275
83Pancreatic cysts (HP:0001737)1.75685693
84Bone marrow hypocellularity (HP:0005528)1.75021806
85Bifid tongue (HP:0010297)1.75010134
86Abnormality of DNA repair (HP:0003254)1.73581311
87Rhabdomyosarcoma (HP:0002859)1.72721958
88Breast hypoplasia (HP:0003187)1.72433246
893-Methylglutaconic aciduria (HP:0003535)1.70927787
90Abnormality of the septum pellucidum (HP:0007375)1.70211907
91Pendular nystagmus (HP:0012043)1.70037444
92Neoplasm of the adrenal cortex (HP:0100641)1.69379875
93Stenosis of the external auditory canal (HP:0000402)1.68510934
94Premature ovarian failure (HP:0008209)1.67598154
95Aqueductal stenosis (HP:0002410)1.66751956
96Nephroblastoma (Wilms tumor) (HP:0002667)1.66404331
97Abnormality of the phalanges of the hallux (HP:0010057)1.65727696
98Postnatal microcephaly (HP:0005484)1.65083498
99Vaginal fistula (HP:0004320)1.64754049
100Abnormal number of erythroid precursors (HP:0012131)1.64725854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.98715993
2CDC74.28548719
3SRPK13.32878736
4ZAK3.05163338
5TTK2.76110562
6TSSK62.53828014
7PLK42.48338867
8TNIK2.33501105
9STK162.26316018
10WEE12.15782002
11PLK32.14118134
12PLK12.06947739
13DYRK31.95283614
14VRK21.86589637
15MKNK21.78511298
16PNCK1.77584844
17ATR1.74373684
18WNK31.73413723
19MAP3K41.63434476
20PBK1.62059119
21FRK1.60199626
22MKNK11.56649685
23NUAK11.54180211
24DYRK21.53675014
25CHEK21.50912396
26PDK21.47227216
27VRK11.45088016
28MAP2K71.36363210
29TLK11.36291655
30BCKDK1.29097972
31TAF11.26463680
32BRSK21.26147279
33BRSK11.25548908
34CDK71.24979192
35MAP3K101.23707336
36BMPR1B1.23525918
37CHEK11.22075050
38NEK11.21038494
39BCR1.18124118
40NME11.17275830
41CDK191.15216160
42AURKA1.13150229
43AURKB1.07858436
44PASK1.05801612
45MAP4K21.04016102
46CSNK1G11.01929411
47ATM0.99695202
48CSNK1G30.98336915
49BRAF0.91891532
50RPS6KA40.91233537
51CSNK1G20.85776980
52NLK0.85613570
53CDK20.83861845
54FGFR20.81229184
55CDK30.80847388
56STK30.78498452
57SIK30.77208144
58EIF2AK20.76577560
59CSNK1A1L0.72998192
60EPHA40.70588978
61CDK10.69854083
62PRKCI0.69524239
63CDK120.68638273
64DYRK1B0.68592703
65ERBB30.68592388
66BRD40.67996853
67STK40.66892062
68EIF2AK30.65430797
69CSNK2A20.64137546
70RPS6KA50.62594427
71CSNK2A10.61632241
72CAMK1G0.60915661
73CASK0.59007788
74SIK20.57553937
75* TRIM280.56145724
76MARK30.55320786
77MST40.54158855
78PIM10.53615551
79EIF2AK10.53129488
80CSNK1E0.51980356
81CDK90.51335344
82PRKCG0.50659412
83NEK20.50177951
84CDK80.48667892
85CDK40.47363794
86MAP3K80.46673010
87UHMK10.43932659
88PRKDC0.43929896
89MELK0.43916420
90CCNB10.38355071
91WNK40.37822778
92GSK3B0.34234638
93DYRK1A0.32993951
94MAPK140.32931029
95NEK60.32174406
96YES10.30807393
97MAPK130.29903363
98RPS6KA10.29469237
99FGFR10.29196402
100PAK10.27675273

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27079629
2Mismatch repair_Homo sapiens_hsa034303.97303907
3Homologous recombination_Homo sapiens_hsa034403.20271427
4Fanconi anemia pathway_Homo sapiens_hsa034603.09676397
5Base excision repair_Homo sapiens_hsa034102.97764953
6RNA polymerase_Homo sapiens_hsa030202.94563946
7Non-homologous end-joining_Homo sapiens_hsa034502.87662218
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84761303
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55921560
10Spliceosome_Homo sapiens_hsa030402.55863004
11Cell cycle_Homo sapiens_hsa041102.54752936
12Ribosome_Homo sapiens_hsa030102.52391757
13RNA transport_Homo sapiens_hsa030132.48719203
14Proteasome_Homo sapiens_hsa030502.34662367
15Basal transcription factors_Homo sapiens_hsa030222.23308145
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19248117
17RNA degradation_Homo sapiens_hsa030182.17636907
18Nucleotide excision repair_Homo sapiens_hsa034202.04848007
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00676951
20Pyrimidine metabolism_Homo sapiens_hsa002401.77350238
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73999665
22Protein export_Homo sapiens_hsa030601.65841289
23Oxidative phosphorylation_Homo sapiens_hsa001901.60181077
24One carbon pool by folate_Homo sapiens_hsa006701.59084426
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58157717
26Parkinsons disease_Homo sapiens_hsa050121.49409772
27Steroid biosynthesis_Homo sapiens_hsa001001.47275971
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.39028776
29mRNA surveillance pathway_Homo sapiens_hsa030151.36906487
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.36818104
31Fatty acid elongation_Homo sapiens_hsa000621.34917468
32Huntingtons disease_Homo sapiens_hsa050161.32080479
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30773160
34p53 signaling pathway_Homo sapiens_hsa041151.24749004
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23653389
36Oocyte meiosis_Homo sapiens_hsa041141.20780238
37Purine metabolism_Homo sapiens_hsa002301.18704393
38Selenocompound metabolism_Homo sapiens_hsa004501.18136957
39Vitamin B6 metabolism_Homo sapiens_hsa007501.16799436
40Propanoate metabolism_Homo sapiens_hsa006401.14114713
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06387825
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05518599
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04294145
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93922358
45Folate biosynthesis_Homo sapiens_hsa007900.93126958
46Regulation of autophagy_Homo sapiens_hsa041400.89707529
47Sulfur relay system_Homo sapiens_hsa041220.88415543
48Biosynthesis of amino acids_Homo sapiens_hsa012300.75639037
49Hedgehog signaling pathway_Homo sapiens_hsa043400.73892471
50N-Glycan biosynthesis_Homo sapiens_hsa005100.68969239
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61162651
52Basal cell carcinoma_Homo sapiens_hsa052170.61137749
53Glutathione metabolism_Homo sapiens_hsa004800.61012196
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60276376
55Butanoate metabolism_Homo sapiens_hsa006500.59753331
56Metabolic pathways_Homo sapiens_hsa011000.58457549
57Pyruvate metabolism_Homo sapiens_hsa006200.52627993
58Caffeine metabolism_Homo sapiens_hsa002320.52280875
59Peroxisome_Homo sapiens_hsa041460.50464715
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48276271
61Alzheimers disease_Homo sapiens_hsa050100.47903332
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46969116
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46233024
64Collecting duct acid secretion_Homo sapiens_hsa049660.44687622
65Epstein-Barr virus infection_Homo sapiens_hsa051690.44460146
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42778702
67TGF-beta signaling pathway_Homo sapiens_hsa043500.41795162
68Taste transduction_Homo sapiens_hsa047420.40896773
69Vitamin digestion and absorption_Homo sapiens_hsa049770.40826200
70Carbon metabolism_Homo sapiens_hsa012000.39936274
71Hippo signaling pathway_Homo sapiens_hsa043900.39465386
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33735985
73Colorectal cancer_Homo sapiens_hsa052100.32973790
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32522747
75Wnt signaling pathway_Homo sapiens_hsa043100.31352750
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29918261
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29852503
78Lysine degradation_Homo sapiens_hsa003100.29808982
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29304172
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27933013
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27032510
82Sulfur metabolism_Homo sapiens_hsa009200.26364390
83Phototransduction_Homo sapiens_hsa047440.24847028
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24707220
85Fatty acid metabolism_Homo sapiens_hsa012120.24344092
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24285111
87Systemic lupus erythematosus_Homo sapiens_hsa053220.24257835
88Fat digestion and absorption_Homo sapiens_hsa049750.23818986
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.22183409
90Alcoholism_Homo sapiens_hsa050340.19930056
91Arginine and proline metabolism_Homo sapiens_hsa003300.19824108
92Nicotine addiction_Homo sapiens_hsa050330.18592873
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16087006
94Cardiac muscle contraction_Homo sapiens_hsa042600.15990192
95Ether lipid metabolism_Homo sapiens_hsa005650.14206873
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14017385
97Viral carcinogenesis_Homo sapiens_hsa052030.13835264
98HTLV-I infection_Homo sapiens_hsa051660.13805133
99Galactose metabolism_Homo sapiens_hsa000520.12613461
100Prostate cancer_Homo sapiens_hsa052150.10669973

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