ZNF69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.27052116
2negative regulation of activin receptor signaling pathway (GO:0032926)6.89799247
3regulation of nuclear cell cycle DNA replication (GO:0033262)6.18115644
4response to pheromone (GO:0019236)5.73744665
5histone-serine phosphorylation (GO:0035404)5.52558769
6mitochondrion distribution (GO:0048311)5.45676828
7protein prenylation (GO:0018342)4.91094423
8prenylation (GO:0097354)4.91094423
9centriole replication (GO:0007099)4.63670639
10regulation of chemokine-mediated signaling pathway (GO:0070099)4.52826965
11arginine catabolic process (GO:0006527)4.41857318
12intraciliary transport (GO:0042073)4.27340465
13regulation of protein localization to cell surface (GO:2000008)4.26848925
14negative regulation of keratinocyte proliferation (GO:0010839)4.04325990
15lipid particle organization (GO:0034389)3.86051462
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.80818860
17mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.80818860
18photoreceptor cell maintenance (GO:0045494)3.74813757
19positive regulation of receptor internalization (GO:0002092)3.67070398
20regulation of sarcomere organization (GO:0060297)3.64595334
21generation of neurons (GO:0048699)3.55135734
22behavioral response to nicotine (GO:0035095)3.52062904
23water-soluble vitamin biosynthetic process (GO:0042364)3.48436731
24embryonic digestive tract development (GO:0048566)3.47447759
25mRNA splice site selection (GO:0006376)3.35503698
26citrulline metabolic process (GO:0000052)3.33045624
27regulation of activin receptor signaling pathway (GO:0032925)3.32451905
28rRNA methylation (GO:0031167)3.29667370
29olfactory bulb development (GO:0021772)3.28055818
30rRNA modification (GO:0000154)3.25874282
31positive regulation of DNA-dependent DNA replication (GO:2000105)3.24164645
32platelet dense granule organization (GO:0060155)3.23549808
33regulation of transforming growth factor beta2 production (GO:0032909)3.20643168
34mitochondrion localization (GO:0051646)3.17905194
35positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.16920730
36positive regulation of cell cycle G2/M phase transition (GO:1902751)3.16920730
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16793557
38nonmotile primary cilium assembly (GO:0035058)3.14127707
39negative regulation of protein localization to cell surface (GO:2000009)3.13226221
40dopamine biosynthetic process (GO:0042416)3.12036477
41establishment of mitochondrion localization (GO:0051654)3.09659872
42protein deneddylation (GO:0000338)3.06448883
43cullin deneddylation (GO:0010388)3.04516242
44aggressive behavior (GO:0002118)3.03307986
45outer ear morphogenesis (GO:0042473)3.01799619
46thyroid hormone metabolic process (GO:0042403)3.00834254
47centriole assembly (GO:0098534)3.00720544
48gene silencing by RNA (GO:0031047)3.00455998
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97969725
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.97243178
51mitochondrion transport along microtubule (GO:0047497)2.97243178
52arginine metabolic process (GO:0006525)2.97117183
53epithelial cilium movement (GO:0003351)2.95439743
54acrosome assembly (GO:0001675)2.92638459
55regulation of telomere maintenance (GO:0032204)2.90938458
56kidney morphogenesis (GO:0060993)2.89786891
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88653525
58appendage development (GO:0048736)2.86890999
59limb development (GO:0060173)2.86890999
60protein localization to microtubule cytoskeleton (GO:0072698)2.85607458
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83639137
62pyrimidine nucleobase catabolic process (GO:0006208)2.83093526
63cellular response to ATP (GO:0071318)2.78031953
64chromatin remodeling at centromere (GO:0031055)2.75991089
65protein neddylation (GO:0045116)2.75672526
66C4-dicarboxylate transport (GO:0015740)2.73291128
67negative regulation of leukocyte chemotaxis (GO:0002689)2.72969625
68histone H2A acetylation (GO:0043968)2.72641707
69CENP-A containing nucleosome assembly (GO:0034080)2.70557625
70regulation of receptor internalization (GO:0002090)2.69766962
71forebrain neuron differentiation (GO:0021879)2.69161378
72retinal ganglion cell axon guidance (GO:0031290)2.67927639
73regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.67516304
74peptidyl-arginine modification (GO:0018195)2.62409078
75transmission of nerve impulse (GO:0019226)2.61709733
76sex differentiation (GO:0007548)2.61476757
77regulation of cardioblast differentiation (GO:0051890)2.60893978
78branched-chain amino acid catabolic process (GO:0009083)2.59559810
79somite development (GO:0061053)2.58590767
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.57804979
81limb bud formation (GO:0060174)2.56948434
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56206349
83positive regulation of T cell apoptotic process (GO:0070234)2.55528560
84DNA damage response, detection of DNA damage (GO:0042769)2.54888735
85positive regulation of receptor-mediated endocytosis (GO:0048260)2.54406392
86positive regulation of multicellular organism growth (GO:0040018)2.54380053
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50985257
88L-fucose catabolic process (GO:0042355)2.50093214
89fucose catabolic process (GO:0019317)2.50093214
90L-fucose metabolic process (GO:0042354)2.50093214
91protein localization to cytoskeleton (GO:0044380)2.49637283
92DNA double-strand break processing (GO:0000729)2.48916404
93mannosylation (GO:0097502)2.48019580
94detection of light stimulus involved in visual perception (GO:0050908)2.47375241
95detection of light stimulus involved in sensory perception (GO:0050962)2.47375241
96replication fork processing (GO:0031297)2.46457947
97cilium morphogenesis (GO:0060271)2.46265052
98vascular smooth muscle contraction (GO:0014829)2.46216655
99protein polyglutamylation (GO:0018095)2.46076235
100nitric oxide mediated signal transduction (GO:0007263)2.45592057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.29907883
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.87594625
3IGF1R_20145208_ChIP-Seq_DFB_Human3.24627706
4EZH2_22144423_ChIP-Seq_EOC_Human2.98846580
5VDR_22108803_ChIP-Seq_LS180_Human2.64289987
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53630184
7GBX2_23144817_ChIP-Seq_PC3_Human2.51465012
8P300_19829295_ChIP-Seq_ESCs_Human2.48768244
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.42995306
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35324414
11EWS_26573619_Chip-Seq_HEK293_Human2.31905736
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22244043
13TAF15_26573619_Chip-Seq_HEK293_Human2.19556268
14FUS_26573619_Chip-Seq_HEK293_Human2.19148597
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14326539
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13647723
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12030853
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06508277
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05440279
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05114929
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.98433895
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89630268
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.81401390
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73687545
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70439300
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68923134
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68781278
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68607549
29MYC_18940864_ChIP-ChIP_HL60_Human1.67555184
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62061585
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59930120
32BCAT_22108803_ChIP-Seq_LS180_Human1.59465216
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59125456
34ER_23166858_ChIP-Seq_MCF-7_Human1.57310389
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57015795
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55508383
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.55276896
38ELK1_19687146_ChIP-ChIP_HELA_Human1.51724270
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46484403
40SMAD4_21799915_ChIP-Seq_A2780_Human1.44228451
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44145782
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42546046
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41328626
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41328626
45IRF1_19129219_ChIP-ChIP_H3396_Human1.40549562
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38632845
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.37458974
48AR_25329375_ChIP-Seq_VCAP_Human1.36825084
49CBP_20019798_ChIP-Seq_JUKART_Human1.36604848
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36604848
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36279391
52* STAT3_23295773_ChIP-Seq_U87_Human1.33848714
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31513591
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31411013
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29973458
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.29896971
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.29663251
58RUNX2_22187159_ChIP-Seq_PCA_Human1.27940755
59TP53_22573176_ChIP-Seq_HFKS_Human1.27105358
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26299850
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26205647
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.26013442
63TCF4_23295773_ChIP-Seq_U87_Human1.25587848
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.25006958
65RNF2_27304074_Chip-Seq_NSC_Mouse1.23565776
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.23060013
67AR_21572438_ChIP-Seq_LNCaP_Human1.19334327
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18811464
69P53_22387025_ChIP-Seq_ESCs_Mouse1.15502112
70P300_18555785_Chip-Seq_ESCs_Mouse1.14287079
71CDX2_22108803_ChIP-Seq_LS180_Human1.13412245
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13037181
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.12859191
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12381974
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12047027
76SOX2_19829295_ChIP-Seq_ESCs_Human1.11849416
77NANOG_19829295_ChIP-Seq_ESCs_Human1.11849416
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.11601884
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.10967276
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.10239096
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09362165
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09122649
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.08904943
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08522631
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.08202048
86TCF4_22108803_ChIP-Seq_LS180_Human1.06712988
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06518010
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04716401
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.04454331
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.04132765
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01778077
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01009196
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.00354983
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00193322
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.99267835
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99016182
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98672174
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98356982
99JUN_21703547_ChIP-Seq_K562_Human0.98026207
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97873679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.09273980
2MP0002876_abnormal_thyroid_physiology3.17692840
3MP0008877_abnormal_DNA_methylation2.87307514
4MP0002163_abnormal_gland_morphology2.83623844
5MP0006292_abnormal_olfactory_placode2.55498278
6MP0006276_abnormal_autonomic_nervous2.47715310
7MP0002736_abnormal_nociception_after2.28910872
8MP0003195_calcinosis2.24730674
9MP0001968_abnormal_touch/_nociception2.13517623
10MP0009053_abnormal_anal_canal2.09097444
11MP0010368_abnormal_lymphatic_system2.05234277
12MP0001529_abnormal_vocalization1.99592957
13MP0003136_yellow_coat_color1.97485853
14MP0002938_white_spotting1.91693147
15MP0005379_endocrine/exocrine_gland_phen1.87470244
16MP0008789_abnormal_olfactory_epithelium1.80795967
17MP0005367_renal/urinary_system_phenotyp1.75056767
18MP0000516_abnormal_urinary_system1.75056767
19MP0003787_abnormal_imprinting1.73878446
20MP0003693_abnormal_embryo_hatching1.71847820
21MP0002102_abnormal_ear_morphology1.66329457
22MP0005085_abnormal_gallbladder_physiolo1.65985456
23MP0000372_irregular_coat_pigmentation1.63200413
24MP0006072_abnormal_retinal_apoptosis1.62622588
25MP0005187_abnormal_penis_morphology1.61293487
26MP0005647_abnormal_sex_gland1.58509524
27MP0004885_abnormal_endolymph1.49951048
28MP0008995_early_reproductive_senescence1.49594192
29MP0003880_abnormal_central_pattern1.48842811
30MP0005499_abnormal_olfactory_system1.41215914
31MP0005394_taste/olfaction_phenotype1.41215914
32MP0005551_abnormal_eye_electrophysiolog1.40708881
33MP0003315_abnormal_perineum_morphology1.40089380
34MP0001293_anophthalmia1.39287898
35MP0002653_abnormal_ependyma_morphology1.38787944
36MP0005423_abnormal_somatic_nervous1.37864523
37MP0000778_abnormal_nervous_system1.37779413
38MP0004133_heterotaxia1.37176924
39MP0003121_genomic_imprinting1.32645806
40MP0003718_maternal_effect1.32027738
41MP0002751_abnormal_autonomic_nervous1.31418372
42MP0003119_abnormal_digestive_system1.29597511
43MP0003122_maternal_imprinting1.27754781
44MP0000049_abnormal_middle_ear1.22809660
45MP0005253_abnormal_eye_physiology1.20490718
46MP0002095_abnormal_skin_pigmentation1.19762520
47MP0000631_abnormal_neuroendocrine_gland1.18187968
48MP0005266_abnormal_metabolism1.17610774
49MP0008058_abnormal_DNA_repair1.16077718
50MP0000647_abnormal_sebaceous_gland1.15715876
51MP0001286_abnormal_eye_development1.12717552
52MP0001485_abnormal_pinna_reflex1.12511507
53MP0003890_abnormal_embryonic-extraembry1.11265954
54MP0001486_abnormal_startle_reflex1.09542079
55MP0000566_synostosis1.08435954
56MP0000427_abnormal_hair_cycle1.08047478
57MP0009697_abnormal_copulation1.04053478
58MP0000569_abnormal_digit_pigmentation1.02772638
59MP0000639_abnormal_adrenal_gland1.01240666
60MP0002234_abnormal_pharynx_morphology1.00905411
61MP0002233_abnormal_nose_morphology1.00825418
62MP0000537_abnormal_urethra_morphology0.99581659
63MP0003011_delayed_dark_adaptation0.99230991
64MP0002735_abnormal_chemical_nociception0.99040683
65MP0003755_abnormal_palate_morphology0.98853098
66MP0002272_abnormal_nervous_system0.98654382
67MP0001929_abnormal_gametogenesis0.97507996
68MP0001905_abnormal_dopamine_level0.97439164
69MP0001984_abnormal_olfaction0.96245673
70MP0002837_dystrophic_cardiac_calcinosis0.95893111
71MP0010030_abnormal_orbit_morphology0.95179222
72MP0002127_abnormal_cardiovascular_syste0.94843466
73MP0003942_abnormal_urinary_system0.93833330
74MP0001879_abnormal_lymphatic_vessel0.93776093
75MP0003567_abnormal_fetal_cardiomyocyte0.92686927
76MP0002734_abnormal_mechanical_nocicepti0.89659544
77MP0000026_abnormal_inner_ear0.88821276
78MP0001119_abnormal_female_reproductive0.88684370
79MP0002282_abnormal_trachea_morphology0.87857480
80MP0005084_abnormal_gallbladder_morpholo0.87781385
81MP0004270_analgesia0.87016806
82MP0002572_abnormal_emotion/affect_behav0.86322126
83MP0009745_abnormal_behavioral_response0.86027903
84MP0003183_abnormal_peptide_metabolism0.85799220
85MP0002277_abnormal_respiratory_mucosa0.84532324
86MP0004142_abnormal_muscle_tone0.83664367
87MP0002210_abnormal_sex_determination0.83522245
88MP0001756_abnormal_urination0.81701938
89MP0003943_abnormal_hepatobiliary_system0.81693057
90MP0005195_abnormal_posterior_eye0.79236067
91MP0008875_abnormal_xenobiotic_pharmacok0.78509125
92MP0004145_abnormal_muscle_electrophysio0.78102123
93MP0002067_abnormal_sensory_capabilities0.77272373
94MP0003937_abnormal_limbs/digits/tail_de0.76610773
95MP0005646_abnormal_pituitary_gland0.76236611
96MP0001963_abnormal_hearing_physiology0.75179196
97MP0002752_abnormal_somatic_nervous0.74968074
98MP0005174_abnormal_tail_pigmentation0.74563523
99MP0001346_abnormal_lacrimal_gland0.74098690
100MP0004924_abnormal_behavior0.72375656

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)9.21577136
2Degeneration of anterior horn cells (HP:0002398)9.21577136
3Abnormality of the lower motor neuron (HP:0002366)8.02681197
4Amyotrophic lateral sclerosis (HP:0007354)8.02159984
5Upper motor neuron abnormality (HP:0002127)6.49162051
6Conjunctival telangiectasia (HP:0000524)5.17211804
7Atrophy/Degeneration involving motor neurons (HP:0007373)5.15053526
8Abnormality of the vasculature of the conjunctiva (HP:0008054)4.25485663
9Impaired proprioception (HP:0010831)4.24611638
10Gaze-evoked nystagmus (HP:0000640)4.20726851
11True hermaphroditism (HP:0010459)3.75073899
12Abolished electroretinogram (ERG) (HP:0000550)3.53563437
13Intestinal atresia (HP:0011100)3.49673227
14Pancreatic fibrosis (HP:0100732)3.40985226
15Pancreatic cysts (HP:0001737)3.30837331
16Hyperglycinemia (HP:0002154)3.21970817
17Abnormality of the labia minora (HP:0012880)3.04648703
18Impaired vibratory sensation (HP:0002495)2.62776968
19Medial flaring of the eyebrow (HP:0010747)2.56628564
20Nephronophthisis (HP:0000090)2.51164514
21Septo-optic dysplasia (HP:0100842)2.46172081
22Volvulus (HP:0002580)2.44225396
23Molar tooth sign on MRI (HP:0002419)2.42525741
24Abnormality of midbrain morphology (HP:0002418)2.42525741
25Rib fusion (HP:0000902)2.42043263
26Abnormality of the renal medulla (HP:0100957)2.35290249
27Oculomotor apraxia (HP:0000657)2.31230688
28Abnormality of the motor neurons (HP:0002450)2.30745397
29Abnormal neuron morphology (HP:0012757)2.30745397
30Clonus (HP:0002169)2.28216302
31Hyperventilation (HP:0002883)2.26463305
32Cystic liver disease (HP:0006706)2.26027515
33Abnormality of ocular smooth pursuit (HP:0000617)2.25059912
34Acute encephalopathy (HP:0006846)2.17826101
35Gait imbalance (HP:0002141)2.15659605
36Congenital primary aphakia (HP:0007707)2.13672157
37Atonic seizures (HP:0010819)2.13277803
38Stenosis of the external auditory canal (HP:0000402)2.10353571
39Abnormality of macular pigmentation (HP:0008002)2.07989615
40Male pseudohermaphroditism (HP:0000037)2.07037610
41Gastrointestinal atresia (HP:0002589)2.06326240
42Nephrogenic diabetes insipidus (HP:0009806)2.04737257
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.03888455
44Abnormal lung lobation (HP:0002101)1.92996572
45Genital tract atresia (HP:0001827)1.92989755
46Renal hypoplasia (HP:0000089)1.91829705
47Sclerocornea (HP:0000647)1.89704068
48Vaginal atresia (HP:0000148)1.88087488
49Acute necrotizing encephalopathy (HP:0006965)1.85900199
50Preaxial hand polydactyly (HP:0001177)1.85763338
51Tubulointerstitial nephritis (HP:0001970)1.85157622
52Hyperglycinuria (HP:0003108)1.83352496
53Abnormality of serine family amino acid metabolism (HP:0010894)1.82928663
54Abnormality of glycine metabolism (HP:0010895)1.82928663
55Chorioretinal atrophy (HP:0000533)1.81923313
56Abnormality of serum amino acid levels (HP:0003112)1.80372827
57Rectovaginal fistula (HP:0000143)1.79987996
58Rectal fistula (HP:0100590)1.79987996
59Postaxial hand polydactyly (HP:0001162)1.79739276
60Methylmalonic acidemia (HP:0002912)1.79172319
61Postaxial foot polydactyly (HP:0001830)1.78357348
62Anophthalmia (HP:0000528)1.77740540
63Optic nerve hypoplasia (HP:0000609)1.77026224
64Mucosal telangiectasiae (HP:0100579)1.74918645
65Occipital encephalocele (HP:0002085)1.70234669
66Anencephaly (HP:0002323)1.69179018
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66458738
68Small hand (HP:0200055)1.65866587
69Hypergammaglobulinemia (HP:0010702)1.65552010
70Congenital hepatic fibrosis (HP:0002612)1.65351105
71Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63430765
72Short 1st metacarpal (HP:0010034)1.63430765
73Poor coordination (HP:0002370)1.61909528
74Limb ataxia (HP:0002070)1.61712899
75Urethral obstruction (HP:0000796)1.60096604
76Curly hair (HP:0002212)1.58789625
77Long clavicles (HP:0000890)1.58545476
78Colon cancer (HP:0003003)1.58252319
79Bile duct proliferation (HP:0001408)1.56066535
80Abnormal biliary tract physiology (HP:0012439)1.56066535
81Narrow forehead (HP:0000341)1.54133242
82Abnormality of the renal cortex (HP:0011035)1.53595221
83Abnormal hair whorl (HP:0010721)1.53334014
84Abnormality of the duodenum (HP:0002246)1.50808093
85Progressive macrocephaly (HP:0004481)1.50642433
86Aplasia/Hypoplasia of the lens (HP:0008063)1.49956013
87Lissencephaly (HP:0001339)1.49047814
88Abnormal mitochondria in muscle tissue (HP:0008316)1.48925578
89Dandy-Walker malformation (HP:0001305)1.48500082
90Oligodactyly (hands) (HP:0001180)1.48278049
91Congenital stationary night blindness (HP:0007642)1.46845487
92Cerebral edema (HP:0002181)1.46406454
93Multicystic kidney dysplasia (HP:0000003)1.46155414
94Partial duplication of the phalanx of hand (HP:0009999)1.45964598
95Supernumerary spleens (HP:0009799)1.45698161
96Abnormality of the 1st metacarpal (HP:0010009)1.44781529
97Methylmalonic aciduria (HP:0012120)1.43746693
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.43559439
99Mitochondrial inheritance (HP:0001427)1.43246542
100Split foot (HP:0001839)1.41949405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.18539454
2BCR3.68305419
3CASK3.48280555
4CDK62.90585642
5WNK32.73348380
6TNIK2.58007422
7MAP4K22.57928806
8STK38L2.48678326
9EPHB22.48111772
10FRK2.43564444
11ZAK2.36853704
12PAK31.95221107
13NUAK11.92167499
14NEK91.79041203
15MKNK21.70634069
16MAP3K41.68886700
17TRIM281.62572000
18BMPR1B1.61386831
19CDK41.60400233
20BCKDK1.56322594
21MAPK131.54086834
22PNCK1.50725191
23MARK11.49129389
24ADRBK21.48811229
25INSRR1.40014044
26VRK11.36095471
27MKNK11.35041857
28PLK21.32592669
29MAP2K71.30432958
30TAF11.28697778
31VRK21.24207527
32STK391.22420430
33GRK11.17262270
34DYRK21.12389224
35PLK41.11244897
36PLK31.10981197
37EPHA41.08607372
38WNK41.03511085
39SGK20.99300982
40OXSR10.96812876
41CSNK1G10.92522142
42CSNK1G20.90914668
43LIMK10.89343194
44CSNK1G30.86845330
45SGK2230.83432786
46SGK4940.83432786
47TIE10.81188808
48ACVR1B0.80949641
49PIK3CA0.79405594
50ERBB30.77728351
51BRSK20.75258578
52DYRK30.74876038
53PLK10.74418367
54PRKCE0.73975180
55PRKCG0.72963331
56PRKD20.71817907
57MATK0.71658030
58CSNK1A1L0.70666536
59FGFR20.69571166
60WEE10.67627154
61TAOK30.67106190
62STK240.64886974
63NTRK20.61396957
64MINK10.59786978
65LMTK20.58813023
66PBK0.57196955
67PKN10.51102180
68PHKG20.48019496
69PHKG10.48019496
70RPS6KA40.47810995
71ATM0.46654574
72SRPK10.44731056
73PAK60.43923151
74CAMKK20.41415506
75EPHA30.40754628
76STK30.40570405
77LATS10.40477119
78PRKACA0.39228125
79PRKCI0.39137903
80FGFR10.38988008
81ATR0.37928926
82CSNK1A10.37744200
83PRKCQ0.37283019
84BUB10.37209069
85PRKG10.37043433
86CDK30.35898437
87NEK60.35667017
88CAMK2A0.34677363
89SGK30.31195157
90CDC70.30287514
91PRKAA10.29648175
92CAMK2D0.29569927
93MAP2K40.29553437
94PRKACG0.29198963
95YES10.28657085
96ADRBK10.28567386
97CSNK1E0.27653232
98PRKCA0.27459763
99CHEK20.27401490
100AURKA0.26957701

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.03624909
2Basal transcription factors_Homo sapiens_hsa030222.94918385
3Propanoate metabolism_Homo sapiens_hsa006402.87938426
4RNA polymerase_Homo sapiens_hsa030202.72555762
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29582988
6Phototransduction_Homo sapiens_hsa047442.24978837
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18533262
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16442121
9Non-homologous end-joining_Homo sapiens_hsa034502.12631157
10Oxidative phosphorylation_Homo sapiens_hsa001901.99046129
11Steroid biosynthesis_Homo sapiens_hsa001001.92906616
12Parkinsons disease_Homo sapiens_hsa050121.92823518
13Peroxisome_Homo sapiens_hsa041461.92783529
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83314043
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78350650
16Fanconi anemia pathway_Homo sapiens_hsa034601.69743461
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57939529
18Vitamin B6 metabolism_Homo sapiens_hsa007501.57194421
19Nicotine addiction_Homo sapiens_hsa050331.56442235
20Butanoate metabolism_Homo sapiens_hsa006501.53218195
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51036982
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50366034
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.44888624
24Caffeine metabolism_Homo sapiens_hsa002321.42874518
25Nitrogen metabolism_Homo sapiens_hsa009101.41969242
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38427857
27RNA degradation_Homo sapiens_hsa030181.38189225
28Proteasome_Homo sapiens_hsa030501.36015971
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35844872
30Homologous recombination_Homo sapiens_hsa034401.31326319
31Linoleic acid metabolism_Homo sapiens_hsa005911.29682522
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28730861
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27906672
34Huntingtons disease_Homo sapiens_hsa050161.27295281
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26977412
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.26735002
37Taste transduction_Homo sapiens_hsa047421.24755704
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17859972
39Cardiac muscle contraction_Homo sapiens_hsa042601.14226517
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12971077
41Alzheimers disease_Homo sapiens_hsa050101.11770718
42Fat digestion and absorption_Homo sapiens_hsa049751.10761870
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.10650497
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07116619
45Selenocompound metabolism_Homo sapiens_hsa004501.05235746
46Retinol metabolism_Homo sapiens_hsa008301.04533195
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.02886701
48beta-Alanine metabolism_Homo sapiens_hsa004101.02227431
49Olfactory transduction_Homo sapiens_hsa047401.02055442
50Ether lipid metabolism_Homo sapiens_hsa005650.99537863
51Fatty acid elongation_Homo sapiens_hsa000620.97737563
52Chemical carcinogenesis_Homo sapiens_hsa052040.97666683
53Cell cycle_Homo sapiens_hsa041100.92618334
54Basal cell carcinoma_Homo sapiens_hsa052170.92012830
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87410347
56Tryptophan metabolism_Homo sapiens_hsa003800.87407817
57Hedgehog signaling pathway_Homo sapiens_hsa043400.85675544
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85586996
59Glutathione metabolism_Homo sapiens_hsa004800.81941976
60Arachidonic acid metabolism_Homo sapiens_hsa005900.81851396
61Regulation of autophagy_Homo sapiens_hsa041400.79712135
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71839518
63Metabolic pathways_Homo sapiens_hsa011000.68387906
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68377081
65Fatty acid degradation_Homo sapiens_hsa000710.68147016
66Purine metabolism_Homo sapiens_hsa002300.66969924
67TGF-beta signaling pathway_Homo sapiens_hsa043500.64398510
68Mismatch repair_Homo sapiens_hsa034300.63737788
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60577449
70Circadian entrainment_Homo sapiens_hsa047130.59496460
71Cocaine addiction_Homo sapiens_hsa050300.58856723
72Oocyte meiosis_Homo sapiens_hsa041140.57239180
73Nucleotide excision repair_Homo sapiens_hsa034200.57044922
74Pyrimidine metabolism_Homo sapiens_hsa002400.57035390
75Pyruvate metabolism_Homo sapiens_hsa006200.55543547
76Salivary secretion_Homo sapiens_hsa049700.55040465
77Glutamatergic synapse_Homo sapiens_hsa047240.53261507
78Insulin secretion_Homo sapiens_hsa049110.53084701
79Fatty acid metabolism_Homo sapiens_hsa012120.52873560
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48945109
81p53 signaling pathway_Homo sapiens_hsa041150.48842353
82Serotonergic synapse_Homo sapiens_hsa047260.48303826
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47431753
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46428950
85Histidine metabolism_Homo sapiens_hsa003400.45892847
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45586027
87Hippo signaling pathway_Homo sapiens_hsa043900.45364905
88Ribosome_Homo sapiens_hsa030100.44947094
89Axon guidance_Homo sapiens_hsa043600.43506706
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42839829
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42494840
92Dopaminergic synapse_Homo sapiens_hsa047280.40030871
93Glycerolipid metabolism_Homo sapiens_hsa005610.38496446
94Amphetamine addiction_Homo sapiens_hsa050310.36985707
95Morphine addiction_Homo sapiens_hsa050320.36306169
96RNA transport_Homo sapiens_hsa030130.34358750
97Sulfur metabolism_Homo sapiens_hsa009200.33719480
98Spliceosome_Homo sapiens_hsa030400.33253295
99GABAergic synapse_Homo sapiens_hsa047270.32703347
100One carbon pool by folate_Homo sapiens_hsa006700.32389713

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