ZNF695

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.93829327
2CENP-A containing nucleosome assembly (GO:0034080)4.76258030
3DNA double-strand break processing (GO:0000729)4.36816628
4DNA replication checkpoint (GO:0000076)4.19492197
5histone exchange (GO:0043486)4.06381260
6kinetochore organization (GO:0051383)4.03984517
7replication fork processing (GO:0031297)3.92502806
8somatic diversification of immune receptors via somatic mutation (GO:0002566)3.91815053
9somatic hypermutation of immunoglobulin genes (GO:0016446)3.91815053
10DNA strand elongation involved in DNA replication (GO:0006271)3.91421043
11kinetochore assembly (GO:0051382)3.89459781
12DNA strand elongation (GO:0022616)3.83903019
13telomere maintenance via semi-conservative replication (GO:0032201)3.76445336
14DNA replication-independent nucleosome assembly (GO:0006336)3.74454352
15DNA replication-independent nucleosome organization (GO:0034724)3.74454352
16regulation of centriole replication (GO:0046599)3.65849373
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62916135
18regulation of mitotic spindle checkpoint (GO:1903504)3.62916135
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.62080207
20establishment of integrated proviral latency (GO:0075713)3.55332112
21DNA replication-dependent nucleosome organization (GO:0034723)3.54892337
22DNA replication-dependent nucleosome assembly (GO:0006335)3.54892337
23synapsis (GO:0007129)3.45882370
24mitotic recombination (GO:0006312)3.40520670
25metaphase plate congression (GO:0051310)3.38015468
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35976947
27DNA catabolic process, exonucleolytic (GO:0000738)3.34348994
28telomere maintenance via recombination (GO:0000722)3.33906184
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.33481540
30histone H2A acetylation (GO:0043968)3.32595530
31cornea development in camera-type eye (GO:0061303)3.32497325
32spindle checkpoint (GO:0031577)3.27760037
33DNA ligation (GO:0006266)3.25738294
34mitotic spindle checkpoint (GO:0071174)3.24697549
35protein localization to kinetochore (GO:0034501)3.23637276
36resolution of meiotic recombination intermediates (GO:0000712)3.22376943
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15968960
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15968960
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15968960
40negative regulation of mitotic sister chromatid separation (GO:2000816)3.15968960
41negative regulation of sister chromatid segregation (GO:0033046)3.15968960
42mitotic metaphase plate congression (GO:0007080)3.14170160
43histone mRNA metabolic process (GO:0008334)3.13350685
44recombinational repair (GO:0000725)3.12451626
45negative regulation of chromosome segregation (GO:0051985)3.10821499
46mitotic sister chromatid segregation (GO:0000070)3.10601511
47double-strand break repair via homologous recombination (GO:0000724)3.09880855
48regulation of centrosome cycle (GO:0046605)3.09051768
49postreplication repair (GO:0006301)3.07706822
50sister chromatid segregation (GO:0000819)3.07543701
51microtubule depolymerization (GO:0007019)3.06026692
52negative regulation of DNA recombination (GO:0045910)3.05920053
53protein K6-linked ubiquitination (GO:0085020)3.02179990
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.99620074
55mitotic G2/M transition checkpoint (GO:0044818)2.96969363
56mitotic spindle assembly checkpoint (GO:0007094)2.95326225
57regulation of DNA endoreduplication (GO:0032875)2.94989488
58purine nucleobase biosynthetic process (GO:0009113)2.94508216
59proteasome assembly (GO:0043248)2.93899824
60non-recombinational repair (GO:0000726)2.93315267
61double-strand break repair via nonhomologous end joining (GO:0006303)2.93315267
62spindle assembly checkpoint (GO:0071173)2.91374543
63nucleobase biosynthetic process (GO:0046112)2.90534219
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89146019
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.88334954
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88070601
67regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88070601
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87701399
69regulation of mitotic sister chromatid separation (GO:0010965)2.87237877
70regulation of mitotic sister chromatid segregation (GO:0033047)2.87237877
71regulation of sister chromatid segregation (GO:0033045)2.87237877
72regulation of centrosome duplication (GO:0010824)2.83883462
73telomere maintenance via telomere lengthening (GO:0010833)2.83097771
74regulation of double-strand break repair via homologous recombination (GO:0010569)2.82261741
75regulation of helicase activity (GO:0051095)2.82120392
76chaperone-mediated protein transport (GO:0072321)2.81972826
77mismatch repair (GO:0006298)2.80713132
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80106000
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78584238
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78584238
81regulation of chromosome segregation (GO:0051983)2.76728891
82centriole replication (GO:0007099)2.76367746
83translesion synthesis (GO:0019985)2.75870800
84mitotic sister chromatid cohesion (GO:0007064)2.75674304
85DNA replication initiation (GO:0006270)2.73072251
86regulation of timing of cell differentiation (GO:0048505)2.73009007
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72000092
88dorsal/ventral axis specification (GO:0009950)2.70963696
89protein neddylation (GO:0045116)2.69107448
90meiotic chromosome segregation (GO:0045132)2.66888898
91protein localization to chromosome, centromeric region (GO:0071459)2.64446466
92regulation of development, heterochronic (GO:0040034)2.63562435
93mitotic nuclear envelope disassembly (GO:0007077)2.63228491
94somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61800260
95isotype switching (GO:0045190)2.61800260
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61800260
97pseudouridine synthesis (GO:0001522)2.61181121
98DNA recombination (GO:0006310)2.60645800
99termination of RNA polymerase II transcription (GO:0006369)2.60188586
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59910820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09991935
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98835338
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92589555
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.21572848
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.17872706
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.16138153
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.12727281
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.96504590
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71143868
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63558324
11ZNF274_21170338_ChIP-Seq_K562_Hela2.58409271
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50295322
13ELK1_19687146_ChIP-ChIP_HELA_Human2.50278323
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.50052884
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27872418
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17647060
17FUS_26573619_Chip-Seq_HEK293_Human2.15453244
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13158164
19EWS_26573619_Chip-Seq_HEK293_Human2.13014645
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.05462204
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00675178
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91956751
23VDR_23849224_ChIP-Seq_CD4+_Human1.88861870
24MYC_18940864_ChIP-ChIP_HL60_Human1.86972529
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85887239
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.85088405
27VDR_22108803_ChIP-Seq_LS180_Human1.83461881
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81951083
29FOXP3_21729870_ChIP-Seq_TREG_Human1.76037783
30AR_21909140_ChIP-Seq_LNCAP_Human1.75042527
31IGF1R_20145208_ChIP-Seq_DFB_Human1.73143923
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71030322
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68643201
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67800701
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62341723
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.55898444
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55122911
38TAF15_26573619_Chip-Seq_HEK293_Human1.53659228
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.53396105
40P300_19829295_ChIP-Seq_ESCs_Human1.48658603
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47651499
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47520720
43TTF2_22483619_ChIP-Seq_HELA_Human1.43167541
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41662815
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41020048
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40794806
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.39796887
48IRF1_19129219_ChIP-ChIP_H3396_Human1.39513694
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35718788
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33750061
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33142844
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32035677
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31745245
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.29779249
55DCP1A_22483619_ChIP-Seq_HELA_Human1.28480769
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.28207720
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.26808452
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25852724
59GBX2_23144817_ChIP-Seq_PC3_Human1.25135667
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21868018
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21523581
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21021484
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19534621
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17314245
65GABP_19822575_ChIP-Seq_HepG2_Human1.12550626
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12155995
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10320273
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10085007
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09342290
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08928081
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08188486
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.03388658
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01783735
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01311483
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97191514
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96282996
77ER_23166858_ChIP-Seq_MCF-7_Human0.96131509
78XRN2_22483619_ChIP-Seq_HELA_Human0.95059843
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94809189
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94719525
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94167116
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93985890
83TP53_22573176_ChIP-Seq_HFKS_Human0.92541089
84CBP_20019798_ChIP-Seq_JUKART_Human0.92029072
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92029072
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91860999
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.90672055
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90044208
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89852397
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89672420
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89577244
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89306416
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87350531
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85422600
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84862588
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84481091
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84300660
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84300660
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.83810061
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82587504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.77277180
2MP0010094_abnormal_chromosome_stability3.68059208
3MP0008057_abnormal_DNA_replication3.48635620
4MP0008058_abnormal_DNA_repair3.40940863
5MP0008877_abnormal_DNA_methylation3.30148265
6MP0003693_abnormal_embryo_hatching3.14027332
7MP0002938_white_spotting2.68702300
8MP0003111_abnormal_nucleus_morphology2.63902086
9MP0002638_abnormal_pupillary_reflex2.62357122
10MP0008789_abnormal_olfactory_epithelium2.53885377
11MP0004957_abnormal_blastocyst_morpholog2.52531261
12MP0003077_abnormal_cell_cycle2.27221771
13MP0003718_maternal_effect2.17443462
14MP0005499_abnormal_olfactory_system2.09013691
15MP0005394_taste/olfaction_phenotype2.09013691
16MP0009697_abnormal_copulation1.99510850
17MP0003941_abnormal_skin_development1.96594313
18MP0003787_abnormal_imprinting1.94241281
19MP0001529_abnormal_vocalization1.86027522
20MP0002102_abnormal_ear_morphology1.84254351
21MP0008932_abnormal_embryonic_tissue1.82515606
22MP0001293_anophthalmia1.82153301
23MP0008007_abnormal_cellular_replicative1.73339744
24MP0003890_abnormal_embryonic-extraembry1.70897627
25MP0003121_genomic_imprinting1.69357157
26MP0006072_abnormal_retinal_apoptosis1.65976539
27MP0003937_abnormal_limbs/digits/tail_de1.60739649
28MP0002736_abnormal_nociception_after1.51671981
29MP0002234_abnormal_pharynx_morphology1.47512978
30MP0003567_abnormal_fetal_cardiomyocyte1.43720500
31MP0005253_abnormal_eye_physiology1.30015362
32MP0000631_abnormal_neuroendocrine_gland1.26554363
33MP0002697_abnormal_eye_size1.26362489
34MP0003786_premature_aging1.26176808
35MP0003136_yellow_coat_color1.25944514
36MP0005551_abnormal_eye_electrophysiolog1.24531728
37MP0003880_abnormal_central_pattern1.24231937
38MP0001929_abnormal_gametogenesis1.24225526
39MP0002210_abnormal_sex_determination1.23628772
40MP0005257_abnormal_intraocular_pressure1.22371403
41MP0000372_irregular_coat_pigmentation1.18219799
42MP0002751_abnormal_autonomic_nervous1.17919176
43MP0001286_abnormal_eye_development1.14337518
44MP0002233_abnormal_nose_morphology1.13174086
45MP0006035_abnormal_mitochondrial_morpho1.11518350
46MP0000049_abnormal_middle_ear1.11343482
47MP0002160_abnormal_reproductive_system1.08559187
48MP0001145_abnormal_male_reproductive1.07535282
49MP0000653_abnormal_sex_gland1.06294660
50MP0003119_abnormal_digestive_system1.05978588
51MP0004133_heterotaxia1.05869107
52MP0005084_abnormal_gallbladder_morpholo1.05656375
53MP0005391_vision/eye_phenotype1.01538638
54MP0001697_abnormal_embryo_size1.00093131
55MP0003755_abnormal_palate_morphology0.99794888
56MP0003698_abnormal_male_reproductive0.99269433
57MP0001968_abnormal_touch/_nociception0.98221285
58MP0000778_abnormal_nervous_system0.96000888
59MP0009672_abnormal_birth_weight0.94673934
60MP0002085_abnormal_embryonic_tissue0.94487015
61MP0004147_increased_porphyrin_level0.93141789
62MP0006276_abnormal_autonomic_nervous0.92078862
63MP0002084_abnormal_developmental_patter0.91781654
64MP0000647_abnormal_sebaceous_gland0.91289647
65MP0004197_abnormal_fetal_growth/weight/0.91210231
66MP0000383_abnormal_hair_follicle0.91094046
67MP0009703_decreased_birth_body0.90862466
68MP0003938_abnormal_ear_development0.90405632
69MP0008995_early_reproductive_senescence0.89379990
70MP0010030_abnormal_orbit_morphology0.86979094
71MP0001324_abnormal_eye_pigmentation0.85976480
72MP0009046_muscle_twitch0.85388821
73MP0001119_abnormal_female_reproductive0.84961937
74MP0001485_abnormal_pinna_reflex0.83862521
75MP0001984_abnormal_olfaction0.83207926
76MP0000427_abnormal_hair_cycle0.83183899
77MP0003186_abnormal_redox_activity0.82593198
78MP0005380_embryogenesis_phenotype0.81669788
79MP0001672_abnormal_embryogenesis/_devel0.81669788
80MP0005195_abnormal_posterior_eye0.81516675
81MP0001730_embryonic_growth_arrest0.81180283
82MP0000428_abnormal_craniofacial_morphol0.81079115
83MP0001764_abnormal_homeostasis0.80431010
84MP0000613_abnormal_salivary_gland0.80342445
85MP0005410_abnormal_fertilization0.79256272
86MP0003861_abnormal_nervous_system0.79113983
87MP0000569_abnormal_digit_pigmentation0.78059139
88MP0002111_abnormal_tail_morphology0.77823829
89MP0010307_abnormal_tumor_latency0.75520880
90MP0002282_abnormal_trachea_morphology0.74748477
91MP0004142_abnormal_muscle_tone0.74235097
92MP0000350_abnormal_cell_proliferation0.74143262
93MP0003195_calcinosis0.68196230
94MP0003935_abnormal_craniofacial_develop0.68007624
95MP0005389_reproductive_system_phenotype0.67974610
96MP0005187_abnormal_penis_morphology0.67879767
97MP0006036_abnormal_mitochondrial_physio0.67679857
98MP0002092_abnormal_eye_morphology0.66589825
99MP0005367_renal/urinary_system_phenotyp0.66379788
100MP0000516_abnormal_urinary_system0.66379788

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.82773647
2Chromsome breakage (HP:0040012)3.56324263
3Meckel diverticulum (HP:0002245)3.47389945
4Abnormality of the ileum (HP:0001549)3.36988354
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.36652237
6Colon cancer (HP:0003003)3.29080679
7Abnormality of chromosome stability (HP:0003220)3.22796371
8Abnormality of the labia minora (HP:0012880)3.14140192
9Hypoplasia of the fovea (HP:0007750)3.09123321
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.09123321
11Optic nerve hypoplasia (HP:0000609)2.87775985
12Abnormality of the preputium (HP:0100587)2.85243028
13Pancreatic cysts (HP:0001737)2.84221628
14Abnormality of the fovea (HP:0000493)2.74629232
15Intestinal atresia (HP:0011100)2.74167299
16Birth length less than 3rd percentile (HP:0003561)2.70533392
17Septo-optic dysplasia (HP:0100842)2.70028932
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.65498618
19Hyperglycinemia (HP:0002154)2.59591070
20Abnormal lung lobation (HP:0002101)2.58216854
21True hermaphroditism (HP:0010459)2.55593884
22Pancreatic fibrosis (HP:0100732)2.53901377
23Ependymoma (HP:0002888)2.52868201
24Acute necrotizing encephalopathy (HP:0006965)2.51515436
25Small intestinal stenosis (HP:0012848)2.50374410
26Duodenal stenosis (HP:0100867)2.50374410
27Pendular nystagmus (HP:0012043)2.46927555
28Acute encephalopathy (HP:0006846)2.46122352
29Abnormality of the duodenum (HP:0002246)2.42550807
30Volvulus (HP:0002580)2.29929509
31Sloping forehead (HP:0000340)2.27704961
32Molar tooth sign on MRI (HP:0002419)2.27317380
33Abnormality of midbrain morphology (HP:0002418)2.27317380
34Triphalangeal thumb (HP:0001199)2.26940217
35Medulloblastoma (HP:0002885)2.23624747
36Glioma (HP:0009733)2.17262932
37Nephronophthisis (HP:0000090)2.12215990
38Abnormality of the carotid arteries (HP:0005344)2.10735187
39Progressive macrocephaly (HP:0004481)2.10718935
40Increased CSF lactate (HP:0002490)2.09615790
41Rhabdomyosarcoma (HP:0002859)2.08308381
42Increased hepatocellular lipid droplets (HP:0006565)2.07802561
43Abnormal mitochondria in muscle tissue (HP:0008316)2.07588561
44Abnormality of serum amino acid levels (HP:0003112)2.06739343
45Methylmalonic acidemia (HP:0002912)2.04281621
46Ectopic kidney (HP:0000086)2.04051351
47Clubbing of toes (HP:0100760)2.03590422
48Biliary tract neoplasm (HP:0100574)2.02249947
49Nephroblastoma (Wilms tumor) (HP:0002667)2.00681444
50Hyperglycinuria (HP:0003108)1.99183216
51Absent radius (HP:0003974)1.97997729
52Hyperalaninemia (HP:0003348)1.97529161
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97529161
54Abnormality of alanine metabolism (HP:0010916)1.97529161
55Abnormality of the septum pellucidum (HP:0007375)1.94854082
56Absent forearm bone (HP:0003953)1.94233990
57Aplasia involving forearm bones (HP:0009822)1.94233990
58Mitochondrial inheritance (HP:0001427)1.94121931
59Stenosis of the external auditory canal (HP:0000402)1.93661532
60Hypoplasia of the pons (HP:0012110)1.93612054
61Patellar aplasia (HP:0006443)1.93329293
62Embryonal renal neoplasm (HP:0011794)1.93260896
63Reticulocytopenia (HP:0001896)1.92698575
64Hypoplastic pelvis (HP:0008839)1.92673614
65Bifid tongue (HP:0010297)1.92641573
66Small hand (HP:0200055)1.92351564
67Cerebral edema (HP:0002181)1.90544992
68Absent septum pellucidum (HP:0001331)1.90376243
69Astrocytoma (HP:0009592)1.89328947
70Abnormality of the astrocytes (HP:0100707)1.89328947
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.87995642
72Bilateral microphthalmos (HP:0007633)1.87742214
73Medial flaring of the eyebrow (HP:0010747)1.87015030
74Abnormality of glycine metabolism (HP:0010895)1.86846650
75Abnormality of serine family amino acid metabolism (HP:0010894)1.86846650
76Oligodactyly (hands) (HP:0001180)1.85994142
77Sclerocornea (HP:0000647)1.85464645
78Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85099253
79Anencephaly (HP:0002323)1.84909889
80Anophthalmia (HP:0000528)1.84714033
81Lipid accumulation in hepatocytes (HP:0006561)1.84049268
82Abnormality of the pons (HP:0007361)1.83996171
83Aplasia/Hypoplasia of the macula (HP:0008059)1.81975728
84Dandy-Walker malformation (HP:0001305)1.79725309
85Myelodysplasia (HP:0002863)1.79493577
86Neoplasm of the colon (HP:0100273)1.79237548
87Preaxial hand polydactyly (HP:0001177)1.77959306
88Aplasia/Hypoplasia of the patella (HP:0006498)1.77170318
89Pancreatic islet-cell hyperplasia (HP:0004510)1.76503970
90Gastrointestinal atresia (HP:0002589)1.76380658
91Optic nerve coloboma (HP:0000588)1.75365226
92Horseshoe kidney (HP:0000085)1.74735917
93Methylmalonic aciduria (HP:0012120)1.73309761
94Astigmatism (HP:0000483)1.72189576
95Type II lissencephaly (HP:0007260)1.70928481
96Abnormality of the renal medulla (HP:0100957)1.68825344
97Absent thumb (HP:0009777)1.67964933
98Hepatic necrosis (HP:0002605)1.67001581
99Genital tract atresia (HP:0001827)1.66105082
100Hepatocellular necrosis (HP:0001404)1.65703396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.63472804
2BUB13.16810592
3WEE13.01499208
4SRPK12.85966798
5ZAK2.81012814
6VRK22.59942309
7TTK2.40912624
8PLK42.40158418
9PBK2.27481565
10MAP4K22.27243310
11FRK2.24901647
12WNK32.24678961
13NUAK12.17259705
14BRSK22.15940117
15MKNK12.14186707
16PLK32.09970117
17MKNK22.03090181
18TRIM281.96517750
19MAPK131.86317710
20VRK11.86139402
21EIF2AK31.79259961
22NEK11.65632770
23TNIK1.63413665
24TSSK61.62330405
25MST41.59389529
26TAF11.55565767
27PLK11.54483152
28BMPR1B1.50143883
29STK38L1.49061014
30STK161.48146940
31INSRR1.42096451
32PNCK1.38426430
33ACVR1B1.37503149
34DYRK21.31016427
35BCR1.29299705
36EIF2AK11.26248499
37MAP3K41.23318721
38CHEK21.18521580
39ATR1.17892889
40CASK1.17623592
41NME11.17046342
42PLK21.13177700
43STK31.10937954
44LATS11.10547548
45DYRK31.08131662
46CSNK1G11.02840423
47NEK20.99828776
48BRSK10.95506025
49GRK10.93516722
50CSNK1G30.92465288
51AURKB0.88380102
52CSNK1G20.87224245
53ATM0.84605793
54ERBB30.80533928
55MAP2K70.79223571
56ADRBK20.78967433
57CSNK1A1L0.77357266
58OXSR10.75839012
59EIF2AK20.72779104
60CCNB10.69837047
61CHEK10.67965409
62CDK190.67700537
63PASK0.62301922
64STK240.60412149
65PTK2B0.58060586
66TLK10.58010272
67PRKCG0.56388878
68CDK70.54615513
69AURKA0.54418909
70STK390.54015256
71YES10.53644084
72CDK30.53197579
73TGFBR10.51568365
74CDK10.50906505
75PAK30.50249386
76EPHA40.48778196
77CSNK2A10.48405681
78ERBB40.46773747
79CSNK2A20.44719251
80RPS6KA40.44476511
81BCKDK0.44219768
82PRKCE0.43264872
83PINK10.42980218
84CSNK1E0.42925628
85IRAK20.42863680
86BRD40.41286558
87CDK20.40136743
88PRKCI0.40071901
89CSNK1A10.36927614
90PRKDC0.35552860
91FGFR20.34671813
92RPS6KA50.34198223
93PKN10.33947898
94CSNK1D0.33425443
95STK40.33407950
96CDK80.33016382
97MAPKAPK50.31462488
98MARK10.31165504
99FLT30.30991183
100PDK20.29981525

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.99488688
2DNA replication_Homo sapiens_hsa030303.74058441
3Homologous recombination_Homo sapiens_hsa034403.36975436
4Fanconi anemia pathway_Homo sapiens_hsa034603.13900912
5Non-homologous end-joining_Homo sapiens_hsa034502.86450861
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74653785
7Proteasome_Homo sapiens_hsa030502.62553230
8RNA polymerase_Homo sapiens_hsa030202.56168826
9Nucleotide excision repair_Homo sapiens_hsa034202.50732963
10Basal transcription factors_Homo sapiens_hsa030222.43736482
11Base excision repair_Homo sapiens_hsa034102.40595380
12Protein export_Homo sapiens_hsa030602.30609928
13RNA transport_Homo sapiens_hsa030132.13601867
14Cell cycle_Homo sapiens_hsa041102.06511740
15One carbon pool by folate_Homo sapiens_hsa006702.03498496
16Spliceosome_Homo sapiens_hsa030402.01139617
17Oxidative phosphorylation_Homo sapiens_hsa001901.98483465
18RNA degradation_Homo sapiens_hsa030181.91409039
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89216468
20Ribosome_Homo sapiens_hsa030101.86242934
21Propanoate metabolism_Homo sapiens_hsa006401.79640646
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78469420
23Parkinsons disease_Homo sapiens_hsa050121.78438549
24Steroid biosynthesis_Homo sapiens_hsa001001.60555246
25Pyrimidine metabolism_Homo sapiens_hsa002401.58625948
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58418698
27Huntingtons disease_Homo sapiens_hsa050161.49281593
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.47785831
29Selenocompound metabolism_Homo sapiens_hsa004501.45986269
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33865492
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28861144
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24959697
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19809384
34Purine metabolism_Homo sapiens_hsa002301.19606994
35Phototransduction_Homo sapiens_hsa047441.13660778
36Pyruvate metabolism_Homo sapiens_hsa006201.12748045
37Butanoate metabolism_Homo sapiens_hsa006501.11111880
38mRNA surveillance pathway_Homo sapiens_hsa030151.08758256
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.03509785
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02502574
41Oocyte meiosis_Homo sapiens_hsa041141.02246884
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02175210
43Alzheimers disease_Homo sapiens_hsa050100.99614068
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96397003
45Vitamin B6 metabolism_Homo sapiens_hsa007500.92508864
46p53 signaling pathway_Homo sapiens_hsa041150.88713520
47Fatty acid elongation_Homo sapiens_hsa000620.86066993
48Glutathione metabolism_Homo sapiens_hsa004800.84378030
49Folate biosynthesis_Homo sapiens_hsa007900.82604209
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81717185
51Nicotine addiction_Homo sapiens_hsa050330.72582193
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68652526
53Metabolic pathways_Homo sapiens_hsa011000.68551976
54Taste transduction_Homo sapiens_hsa047420.63882884
55TGF-beta signaling pathway_Homo sapiens_hsa043500.63309433
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62834008
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61709456
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60822374
59Tryptophan metabolism_Homo sapiens_hsa003800.60809296
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60047714
61Biosynthesis of amino acids_Homo sapiens_hsa012300.58776766
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57714661
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56529839
64Basal cell carcinoma_Homo sapiens_hsa052170.55670850
65Cardiac muscle contraction_Homo sapiens_hsa042600.55643557
66Carbon metabolism_Homo sapiens_hsa012000.55311135
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50742922
68Olfactory transduction_Homo sapiens_hsa047400.49814200
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.49487872
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48696572
71Retinol metabolism_Homo sapiens_hsa008300.48329510
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47049793
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46622311
74Lysine degradation_Homo sapiens_hsa003100.46278843
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46236403
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45011267
77Linoleic acid metabolism_Homo sapiens_hsa005910.44851936
78Peroxisome_Homo sapiens_hsa041460.43950775
79Vitamin digestion and absorption_Homo sapiens_hsa049770.43874387
80Hedgehog signaling pathway_Homo sapiens_hsa043400.42470707
81Hippo signaling pathway_Homo sapiens_hsa043900.42298414
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41573511
83Ether lipid metabolism_Homo sapiens_hsa005650.39321376
84Chemical carcinogenesis_Homo sapiens_hsa052040.39292502
85Fatty acid metabolism_Homo sapiens_hsa012120.38846951
86beta-Alanine metabolism_Homo sapiens_hsa004100.38425481
87Nitrogen metabolism_Homo sapiens_hsa009100.38137574
88Wnt signaling pathway_Homo sapiens_hsa043100.37821791
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37579898
90Alcoholism_Homo sapiens_hsa050340.37259292
91Caffeine metabolism_Homo sapiens_hsa002320.36145494
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35934889
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34879495
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34334714
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.34269951
96Regulation of autophagy_Homo sapiens_hsa041400.33891104
97Systemic lupus erythematosus_Homo sapiens_hsa053220.33289316
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33218528
99Arginine and proline metabolism_Homo sapiens_hsa003300.30386020
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25309535

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