ZNF697

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of fever generation (GO:0031620)5.03119610
2positive regulation of heat generation (GO:0031652)4.82762085
3nuclear pore complex assembly (GO:0051292)4.52940446
4regulation of NFAT protein import into nucleus (GO:0051532)4.52810086
5regulation of vitamin D biosynthetic process (GO:0060556)3.95431913
6nuclear pore organization (GO:0006999)3.90364438
7pre-miRNA processing (GO:0031054)3.83268367
8regulation of cAMP-dependent protein kinase activity (GO:2000479)3.77795706
9protein localization to endosome (GO:0036010)3.68402054
10regulation of heat generation (GO:0031650)3.68055457
11substrate-dependent cell migration (GO:0006929)3.62778501
12cell adhesion mediated by integrin (GO:0033627)3.60969158
13pore complex assembly (GO:0046931)3.60384975
14cellular protein complex localization (GO:0034629)3.43090476
15protein localization to microtubule (GO:0035372)3.35395003
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34494304
17positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29732020
18paraxial mesoderm development (GO:0048339)3.25510586
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.24422581
20axon extension involved in axon guidance (GO:0048846)3.24422581
21osteoclast differentiation (GO:0030316)3.21655311
22axon extension (GO:0048675)3.20809160
23regulation of early endosome to late endosome transport (GO:2000641)3.16534731
24endodermal cell differentiation (GO:0035987)3.07686687
25cell migration involved in sprouting angiogenesis (GO:0002042)3.07472912
26glycosphingolipid catabolic process (GO:0046479)3.04939820
27oligosaccharide catabolic process (GO:0009313)3.01160756
28L-alpha-amino acid transmembrane transport (GO:1902475)2.96361570
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.95580618
30epithelial cell-cell adhesion (GO:0090136)2.94081973
31chondrocyte proliferation (GO:0035988)2.88489066
32protein complex localization (GO:0031503)2.86600791
33heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.86320809
34positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85228256
35ganglion development (GO:0061548)2.83981768
36positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.83495044
37regulation of RNA export from nucleus (GO:0046831)2.78787651
38skin morphogenesis (GO:0043589)2.78767375
39positive regulation of SMAD protein import into nucleus (GO:0060391)2.78232526
40positive regulation of catenin import into nucleus (GO:0035413)2.78080136
41wound healing, spreading of epidermal cells (GO:0035313)2.77327020
42neuron projection extension (GO:1990138)2.72005603
43regulation of membrane protein ectodomain proteolysis (GO:0051043)2.68169339
44glycolipid catabolic process (GO:0019377)2.65103047
45glial cell migration (GO:0008347)2.64097247
46chondrocyte development (GO:0002063)2.63552866
47embryonic process involved in female pregnancy (GO:0060136)2.59143578
48regulation of mononuclear cell migration (GO:0071675)2.57821980
49regulation of vitamin metabolic process (GO:0030656)2.57399692
50positive regulation of p38MAPK cascade (GO:1900745)2.56637772
51protein localization to kinetochore (GO:0034501)2.55511097
52mesodermal cell differentiation (GO:0048333)2.54559189
53monocyte chemotaxis (GO:0002548)2.54528631
54lymphangiogenesis (GO:0001946)2.52431541
55artery development (GO:0060840)2.52321972
56COPI coating of Golgi vesicle (GO:0048205)2.52275060
57Golgi transport vesicle coating (GO:0048200)2.52275060
58negative regulation of focal adhesion assembly (GO:0051895)2.52225469
59negative regulation of cell junction assembly (GO:1901889)2.52225469
60negative regulation of adherens junction organization (GO:1903392)2.52225469
61trophoblast giant cell differentiation (GO:0060707)2.51165456
62semaphorin-plexin signaling pathway (GO:0071526)2.48424159
63positive regulation vascular endothelial growth factor production (GO:0010575)2.48358436
64positive regulation of chemokine biosynthetic process (GO:0045080)2.47404843
65cellular copper ion homeostasis (GO:0006878)2.45643130
66regulation of nucleobase-containing compound transport (GO:0032239)2.45490229
67atrial septum morphogenesis (GO:0060413)2.41057728
68heterochromatin organization (GO:0070828)2.39860128
69regulation of vascular endothelial growth factor production (GO:0010574)2.39047124
70chondroitin sulfate biosynthetic process (GO:0030206)2.38871041
71hippo signaling (GO:0035329)2.38745857
72nodal signaling pathway (GO:0038092)2.35812448
73cellular response to nicotine (GO:0071316)2.35090935
74planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34607418
75neuron recognition (GO:0008038)2.33696590
76cellular response to nerve growth factor stimulus (GO:1990090)2.32875353
77response to nerve growth factor (GO:1990089)2.32875353
78mating behavior (GO:0007617)2.32500429
79anterior/posterior axis specification, embryo (GO:0008595)2.31844810
80cell migration in hindbrain (GO:0021535)2.30369802
81positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.28661861
82protein localization to chromosome, centromeric region (GO:0071459)2.27459124
83wound healing, spreading of cells (GO:0044319)2.26916022
84Notch signaling involved in heart development (GO:0061314)2.25756914
85activin receptor signaling pathway (GO:0032924)2.25001008
86response to lipoprotein particle (GO:0055094)2.24532700
87regulation of cell fate specification (GO:0042659)2.24080330
88gastrulation with mouth forming second (GO:0001702)2.23812490
89diaphragm development (GO:0060539)2.22583602
90craniofacial suture morphogenesis (GO:0097094)2.22578703
91negative regulation of histone methylation (GO:0031061)2.20907466
92embryonic foregut morphogenesis (GO:0048617)2.20625058
93adherens junction assembly (GO:0034333)2.20380958
94regulation of catenin import into nucleus (GO:0035412)2.19982916
95cell surface receptor signaling pathway involved in heart development (GO:0061311)2.17932554
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16829041
97regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.15991638
98nerve growth factor signaling pathway (GO:0038180)2.15038143
99negative regulation of NF-kappaB import into nucleus (GO:0042347)2.14952222
100developmental cell growth (GO:0048588)2.14707546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1WT1_19549856_ChIP-ChIP_CCG9911_Human4.02063603
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.74800917
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.73598045
4SALL4_18804426_ChIP-ChIP_MESCs_Mouse3.14143912
5TCF3_18467660_ChIP-ChIP_MESCs_Mouse3.12388756
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.98498269
7HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.70522132
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60470825
9CLOCK_20551151_ChIP-Seq_293T_Human2.47783761
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33400577
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15770890
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14248987
13SALL4_18804426_ChIP-ChIP_XEN_Mouse1.98222851
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.92670080
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91013089
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90868071
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90868071
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90868071
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.86647131
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85475128
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81580658
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.80007580
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76314568
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73747116
25AR_21909140_ChIP-Seq_LNCAP_Human1.68671353
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66768032
27NFIB_24661679_ChIP-Seq_LUNG_Mouse1.65195528
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64322699
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64203777
30* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63222700
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59664389
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58380858
33E2F7_22180533_ChIP-Seq_HELA_Human1.57947269
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56992902
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53714995
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53213907
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51753860
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.46558877
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46205435
40BRD4_25478319_ChIP-Seq_HGPS_Human1.45584873
41SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43630742
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43162456
43* UBF1/2_26484160_Chip-Seq_HMECs_Human1.41903567
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40963204
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.40356211
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40220222
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40220222
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40119427
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38334025
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36424344
51* KDM2B_26808549_Chip-Seq_K562_Human1.36282125
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33855652
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33655230
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33655230
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33221533
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.31312418
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28149491
58PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26130450
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25639676
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.24546436
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23383062
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22390348
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22388008
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.21785340
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20696471
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17831002
67TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17712151
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17100497
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15540770
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15445458
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13916825
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13238318
73TP53_18474530_ChIP-ChIP_U2OS_Human1.12054153
74TFEB_21752829_ChIP-Seq_HELA_Human1.10424318
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08323058
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07274890
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06715078
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.06242606
79REST_19997604_ChIP-ChIP_NEURONS_Mouse1.04531793
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04071477
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.03570313
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.03311983
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03227947
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02035582
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.01384424
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01381451
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01151000
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99666504
89CJUN_26792858_Chip-Seq_BT549_Human0.99529107
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99187717
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98704378
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97289461
93ZNF263_19887448_ChIP-Seq_K562_Human0.93438001
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.93008057
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92892954
96NANOG_16518401_ChIP-PET_MESCs_Mouse0.92604224
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91579256
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91284225
99EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91284225
100VDR_24787735_ChIP-Seq_THP-1_Human0.90554383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.40110128
2MP0005257_abnormal_intraocular_pressure3.30728579
3MP0010352_gastrointestinal_tract_polyps3.07453837
4MP0003705_abnormal_hypodermis_morpholog3.04101044
5MP0004272_abnormal_basement_membrane3.00746475
6MP0004510_myositis2.70430699
7MP0002877_abnormal_melanocyte_morpholog2.61740616
8MP0003890_abnormal_embryonic-extraembry2.46963790
9MP0003303_peritoneal_inflammation2.43186409
10MP0005058_abnormal_lysosome_morphology2.11252835
11MP0003941_abnormal_skin_development2.00524386
12MP0003566_abnormal_cell_adhesion1.96525251
13MP0003091_abnormal_cell_migration1.91022657
14MP0000537_abnormal_urethra_morphology1.87361921
15MP0005171_absent_coat_pigmentation1.81894478
16MP0009840_abnormal_foam_cell1.81871770
17MP0006054_spinal_hemorrhage1.77561777
18MP0004233_abnormal_muscle_weight1.74306873
19MP0005197_abnormal_uvea_morphology1.72066705
20MP0001915_intracranial_hemorrhage1.71465259
21MP0005076_abnormal_cell_differentiation1.67649752
22MP0005623_abnormal_meninges_morphology1.64426268
23MP0002254_reproductive_system_inflammat1.61002645
24MP0000371_diluted_coat_color1.60557312
25MP0009053_abnormal_anal_canal1.55452926
26MP0005451_abnormal_body_composition1.55242858
27MP0010368_abnormal_lymphatic_system1.54593925
28MP0002697_abnormal_eye_size1.53504637
29MP0003221_abnormal_cardiomyocyte_apopto1.53151268
30MP0003950_abnormal_plasma_membrane1.50447190
31MP0001299_abnormal_eye_distance/1.49207377
32MP0003828_pulmonary_edema1.44509423
33MP0002822_catalepsy1.37068053
34MP0009672_abnormal_birth_weight1.36986190
35MP0003172_abnormal_lysosome_physiology1.36315180
36MP0010307_abnormal_tumor_latency1.35892550
37MP0003385_abnormal_body_wall1.34720851
38MP0000569_abnormal_digit_pigmentation1.33112894
39MP0005408_hypopigmentation1.30773138
40MP0008004_abnormal_stomach_pH1.28295261
41MP0005409_darkened_coat_color1.28186225
42MP0003937_abnormal_limbs/digits/tail_de1.27551487
43MP0003123_paternal_imprinting1.26544886
44MP0001730_embryonic_growth_arrest1.23963992
45MP0000343_altered_response_to1.22851328
46MP0010030_abnormal_orbit_morphology1.21970320
47MP0002998_abnormal_bone_remodeling1.21667470
48MP0000428_abnormal_craniofacial_morphol1.19907812
49MP0000767_abnormal_smooth_muscle1.18984498
50MP0003279_aneurysm1.16340925
51MP0001849_ear_inflammation1.16318982
52MP0003453_abnormal_keratinocyte_physiol1.14922565
53MP0002084_abnormal_developmental_patter1.14388127
54MP0009250_abnormal_appendicular_skeleto1.12999708
55MP0002089_abnormal_postnatal_growth/wei1.12851469
56MP0002092_abnormal_eye_morphology1.12843531
57MP0003567_abnormal_fetal_cardiomyocyte1.12661982
58MP0003448_altered_tumor_morphology1.12131340
59MP0005380_embryogenesis_phenotype1.11575208
60MP0001672_abnormal_embryogenesis/_devel1.11575208
61MP0009278_abnormal_bone_marrow1.09293785
62MP0003634_abnormal_glial_cell1.08689745
63MP0009384_cardiac_valve_regurgitation1.07115708
64MP0000733_abnormal_muscle_development1.06635571
65MP0002896_abnormal_bone_mineralization1.06087773
66MP0005248_abnormal_Harderian_gland1.05958975
67MP0009697_abnormal_copulation1.04687471
68MP0002088_abnormal_embryonic_growth/wei1.04490731
69MP0005167_abnormal_blood-brain_barrier1.04186684
70MP0003984_embryonic_growth_retardation1.03668666
71MP0002086_abnormal_extraembryonic_tissu1.03003089
72MP0002085_abnormal_embryonic_tissue1.02782162
73MP0001186_pigmentation_phenotype1.02736460
74MP0008932_abnormal_embryonic_tissue1.01247173
75MP0002925_abnormal_cardiovascular_devel0.99016271
76MP0004270_analgesia0.98473701
77MP0000534_abnormal_ureter_morphology0.97815036
78MP0000778_abnormal_nervous_system0.94939868
79MP0000432_abnormal_head_morphology0.94007157
80MP0000750_abnormal_muscle_regeneration0.93815736
81MP0003935_abnormal_craniofacial_develop0.93520669
82MP0002090_abnormal_vision0.91808621
83MP0002075_abnormal_coat/hair_pigmentati0.89987530
84MP0003942_abnormal_urinary_system0.89476119
85MP0004957_abnormal_blastocyst_morpholog0.88591140
86MP0000604_amyloidosis0.87978558
87MP0003300_gastrointestinal_ulcer0.87976417
88MP0003119_abnormal_digestive_system0.87564685
89MP0009703_decreased_birth_body0.86556148
90MP0004858_abnormal_nervous_system0.86219400
91MP0004197_abnormal_fetal_growth/weight/0.86136900
92MP0002139_abnormal_hepatobiliary_system0.84519002
93MP0001324_abnormal_eye_pigmentation0.83784456
94MP0002332_abnormal_exercise_endurance0.83661840
95MP0004185_abnormal_adipocyte_glucose0.82917289
96MP0001697_abnormal_embryo_size0.79342508
97MP0001614_abnormal_blood_vessel0.79087957
98MP0008057_abnormal_DNA_replication0.78423672
99MP0005193_abnormal_anterior_eye0.77250153
100MP0002080_prenatal_lethality0.75714458

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)5.37668446
2Premature rupture of membranes (HP:0001788)3.22905298
3Abnormality of glycolipid metabolism (HP:0010969)3.21330880
4Abnormality of liposaccharide metabolism (HP:0010968)3.21330880
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.21330880
6Neurofibrillary tangles (HP:0002185)3.06120124
7Myocardial infarction (HP:0001658)2.92992135
8Protrusio acetabuli (HP:0003179)2.77322817
9Disinhibition (HP:0000734)2.67342456
10Spinal cord lesions (HP:0100561)2.65214919
11Syringomyelia (HP:0003396)2.65214919
12Cerebral inclusion bodies (HP:0100314)2.59307361
13Spinal rigidity (HP:0003306)2.42701093
14Insidious onset (HP:0003587)2.42158618
15Termporal pattern (HP:0011008)2.42158618
16Ankle contracture (HP:0006466)2.38857759
17Apathy (HP:0000741)2.35988857
18Upper limb muscle weakness (HP:0003484)2.32447259
19Shoulder girdle muscle weakness (HP:0003547)2.23459967
20Spastic diplegia (HP:0001264)2.22484204
21Skull defect (HP:0001362)2.22365537
22Inappropriate behavior (HP:0000719)2.20957297
23Diminished motivation (HP:0000745)2.19089078
24Progressive sensorineural hearing impairment (HP:0000408)2.12424912
25Large earlobe (HP:0009748)2.10128574
26Arnold-Chiari malformation (HP:0002308)2.06794707
27Increased cerebral lipofuscin (HP:0011813)2.05396671
28Genu recurvatum (HP:0002816)1.99706168
29Hepatoblastoma (HP:0002884)1.98172775
30Long palpebral fissure (HP:0000637)1.98024054
31Lower limb amyotrophy (HP:0007210)1.97748082
32Upper motor neuron abnormality (HP:0002127)1.97403960
33Abnormality of the lumbar spine (HP:0100712)1.96801937
34Vertebral compression fractures (HP:0002953)1.96685950
35Drooling (HP:0002307)1.95569350
36Hand muscle atrophy (HP:0009130)1.94369627
37Uterine leiomyosarcoma (HP:0002891)1.94361339
38Leiomyosarcoma (HP:0100243)1.94361339
39Esophageal varix (HP:0002040)1.91139633
40Skin nodule (HP:0200036)1.90602753
41Persistence of primary teeth (HP:0006335)1.89043731
42Peripheral hypomyelination (HP:0007182)1.87953985
43Tetraparesis (HP:0002273)1.87845144
44Vertebral arch anomaly (HP:0008438)1.84839446
45Hyperacusis (HP:0010780)1.83626769
46Relative macrocephaly (HP:0004482)1.83468036
47Loss of speech (HP:0002371)1.82961052
48Hammertoe (HP:0001765)1.82342646
49Nuclear cataract (HP:0100018)1.79786233
50Abnormality of dentin (HP:0010299)1.79614901
51Overgrowth (HP:0001548)1.78950524
52Pulmonic stenosis (HP:0001642)1.77803061
53Papillary thyroid carcinoma (HP:0002895)1.76168463
54Abnormality of the distal phalanx of the thumb (HP:0009617)1.76048302
55Asymmetry of the thorax (HP:0001555)1.75567101
56Hypopigmentation of the fundus (HP:0007894)1.74046989
57Hypoventilation (HP:0002791)1.73535792
58Upper limb amyotrophy (HP:0009129)1.72974520
59Distal upper limb amyotrophy (HP:0007149)1.72974520
60Myelomeningocele (HP:0002475)1.71968205
61Excessive salivation (HP:0003781)1.71003635
62Bladder carcinoma (HP:0002862)1.69962017
63Bladder neoplasm (HP:0009725)1.69962017
64Pelvic girdle muscle weakness (HP:0003749)1.69876497
65Achilles tendon contracture (HP:0001771)1.69817689
66Transitional cell carcinoma of the bladder (HP:0006740)1.69281615
67Mitral valve prolapse (HP:0001634)1.69256867
68Shallow orbits (HP:0000586)1.69017263
69Abnormality of the hip-girdle musculature (HP:0001445)1.66895738
70Abnormality of the musculature of the pelvis (HP:0001469)1.66895738
71Short nail (HP:0001799)1.65367170
72Disproportionate tall stature (HP:0001519)1.65259994
73Long toe (HP:0010511)1.64133295
74Distal lower limb amyotrophy (HP:0008944)1.62942076
75Abnormal ossification of hand bones (HP:0005921)1.62657819
76Pathologic fracture (HP:0002756)1.62055140
77Vacuolated lymphocytes (HP:0001922)1.61323382
78Buphthalmos (HP:0000557)1.60504341
79Gastrointestinal carcinoma (HP:0002672)1.60301852
80Malignant gastrointestinal tract tumors (HP:0006749)1.60301852
81Mutism (HP:0002300)1.59736193
82Ulnar bowing (HP:0003031)1.59611587
83Cubitus valgus (HP:0002967)1.59566674
84Abnormality of carpal bone ossification (HP:0006257)1.58254397
85Arterial tortuosity (HP:0005116)1.58017452
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57733797
87Insomnia (HP:0100785)1.55761869
88Renal cell carcinoma (HP:0005584)1.55644747
89Thoracolumbar scoliosis (HP:0002944)1.53373624
90Flat acetabular roof (HP:0003180)1.53229549
91Supranuclear gaze palsy (HP:0000605)1.52364066
92Natal tooth (HP:0000695)1.52359239
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.52138627
94Short 4th metacarpal (HP:0010044)1.52138627
95Renal duplication (HP:0000075)1.52121224
96Limb-girdle muscle weakness (HP:0003325)1.52062625
97Metaphyseal irregularity (HP:0003025)1.51649067
98Freckling (HP:0001480)1.51281798
99Bladder diverticulum (HP:0000015)1.51007347
100Thin bony cortex (HP:0002753)1.48963345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.38772698
2LATS23.26296351
3DDR22.81420128
4PDGFRA2.63954902
5ERBB42.59611303
6CASK2.48020748
7ICK2.43968323
8MARK12.31162396
9BRD42.19364535
10MKNK22.12736818
11NTRK11.79588727
12CAMK1G1.71519349
13TTN1.64045416
14MAP3K91.61879932
15MAP3K61.61155392
16MKNK11.60338053
17DYRK31.56646163
18PAK41.56113987
19STK241.55907482
20CAMK1D1.55173421
21BRAF1.54409939
22KSR11.53275205
23TSSK61.51030411
24AKT31.45984992
25TYRO31.38286641
26CDK121.36548415
27PNCK1.36282479
28TAF11.33975170
29TTK1.33279749
30TAOK21.29598188
31NEK91.29263796
32MAP3K41.26846155
33EIF2AK31.24570673
34WEE11.23392667
35SRPK11.23302983
36PTK21.20240511
37TIE11.20211228
38RIPK11.19053581
39MAP2K71.16956647
40CLK11.13698967
41MATK1.05259907
42TNIK1.04831819
43FGR1.03281629
44LATS11.02686041
45NME20.95942492
46MAP3K140.95763846
47PRPF4B0.94587069
48LIMK10.93781217
49EPHB20.92096080
50PDGFRB0.91511298
51MOS0.91289498
52BCR0.89866621
53KSR20.89664491
54EEF2K0.88575589
55DMPK0.88435331
56RPS6KA20.88335521
57IRAK20.88154828
58STK38L0.86116578
59STK30.85774767
60GRK70.83935187
61BRSK20.78471589
62SGK30.77632379
63MTOR0.77332245
64MAP3K50.76014379
65CDK150.74091825
66CDK180.73119092
67TRIM280.70005075
68WNK30.69903911
69SGK20.69111938
70ERBB30.68587493
71ABL20.66835383
72CSNK1G20.66350083
73CSNK1A1L0.65943373
74CDK140.64844361
75TAOK10.64745450
76CDK11A0.64740907
77GSK3A0.63973265
78ALK0.63780741
79DYRK20.59939298
80PAK20.57608147
81CDK60.55853573
82MAP2K40.52591426
83MAP3K80.51813824
84BMPR20.51539095
85TGFBR20.47751279
86WNK10.47307864
87CDC42BPA0.46468091
88CHEK20.45470518
89PRKD30.45177315
90MAP3K100.44883489
91FGFR10.44313058
92SGK2230.42497447
93SGK4940.42497447
94CSNK1G10.39439236
95YES10.38165162
96PIM20.37116675
97CSNK1G30.37040090
98ROCK20.35083425
99PBK0.34288916
100CHUK0.31227531

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.52743181
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.72143456
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07709429
4Prion diseases_Homo sapiens_hsa050201.86148341
5Steroid biosynthesis_Homo sapiens_hsa001001.83796486
6Bladder cancer_Homo sapiens_hsa052191.77757803
7Salmonella infection_Homo sapiens_hsa051321.71574937
8Lysosome_Homo sapiens_hsa041421.66958026
9Adherens junction_Homo sapiens_hsa045201.63650353
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60029311
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.53644750
12Amoebiasis_Homo sapiens_hsa051461.52705514
13TNF signaling pathway_Homo sapiens_hsa046681.49542764
14Legionellosis_Homo sapiens_hsa051341.44982883
15Other glycan degradation_Homo sapiens_hsa005111.42940097
16MicroRNAs in cancer_Homo sapiens_hsa052061.39720061
17Proteoglycans in cancer_Homo sapiens_hsa052051.36251987
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33754657
19TGF-beta signaling pathway_Homo sapiens_hsa043501.33567773
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29043711
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.23533401
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23465734
23Focal adhesion_Homo sapiens_hsa045101.21812140
24Prolactin signaling pathway_Homo sapiens_hsa049171.19734835
25Endometrial cancer_Homo sapiens_hsa052131.19634536
26Renal cell carcinoma_Homo sapiens_hsa052111.19454959
27Rheumatoid arthritis_Homo sapiens_hsa053231.19258630
28ECM-receptor interaction_Homo sapiens_hsa045121.19045498
29Chronic myeloid leukemia_Homo sapiens_hsa052201.17420121
30Malaria_Homo sapiens_hsa051441.16480271
31ErbB signaling pathway_Homo sapiens_hsa040121.14453850
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13996182
33Thyroid cancer_Homo sapiens_hsa052161.12770045
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11566453
35Prostate cancer_Homo sapiens_hsa052151.11398329
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.10673690
37Pertussis_Homo sapiens_hsa051331.10292659
38Vibrio cholerae infection_Homo sapiens_hsa051101.10132671
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07695858
40Shigellosis_Homo sapiens_hsa051311.06508820
41Type II diabetes mellitus_Homo sapiens_hsa049301.04215243
42Small cell lung cancer_Homo sapiens_hsa052221.04198892
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02401023
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01654727
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00754765
46Hippo signaling pathway_Homo sapiens_hsa043900.99469430
47Sphingolipid metabolism_Homo sapiens_hsa006000.97666744
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95297824
49Gap junction_Homo sapiens_hsa045400.95186867
50Phagosome_Homo sapiens_hsa041450.94518210
51Colorectal cancer_Homo sapiens_hsa052100.91402940
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91186015
53Melanoma_Homo sapiens_hsa052180.87957284
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86380608
55Osteoclast differentiation_Homo sapiens_hsa043800.85165535
56Axon guidance_Homo sapiens_hsa043600.83479388
57Hepatitis B_Homo sapiens_hsa051610.83247579
58Estrogen signaling pathway_Homo sapiens_hsa049150.82834056
59Pancreatic cancer_Homo sapiens_hsa052120.82035588
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81893242
61Rap1 signaling pathway_Homo sapiens_hsa040150.81076698
62Glioma_Homo sapiens_hsa052140.78915945
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78842997
64Dilated cardiomyopathy_Homo sapiens_hsa054140.78756764
65Cocaine addiction_Homo sapiens_hsa050300.75625008
66Pathways in cancer_Homo sapiens_hsa052000.74963293
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.73199153
68Insulin signaling pathway_Homo sapiens_hsa049100.71670353
69mTOR signaling pathway_Homo sapiens_hsa041500.71304479
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70219551
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70165007
72VEGF signaling pathway_Homo sapiens_hsa043700.69627298
73Apoptosis_Homo sapiens_hsa042100.69340624
74p53 signaling pathway_Homo sapiens_hsa041150.69198439
75MAPK signaling pathway_Homo sapiens_hsa040100.68212522
76Tight junction_Homo sapiens_hsa045300.67675866
77Fatty acid biosynthesis_Homo sapiens_hsa000610.67187939
78mRNA surveillance pathway_Homo sapiens_hsa030150.66901298
79Cell cycle_Homo sapiens_hsa041100.66884019
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.66720924
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66158806
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65913921
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64996389
84Wnt signaling pathway_Homo sapiens_hsa043100.63945195
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62962433
86Viral carcinogenesis_Homo sapiens_hsa052030.62925843
87Tuberculosis_Homo sapiens_hsa051520.62862113
88Basal cell carcinoma_Homo sapiens_hsa052170.62647454
89GnRH signaling pathway_Homo sapiens_hsa049120.61664568
90Melanogenesis_Homo sapiens_hsa049160.60418077
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60378795
92Notch signaling pathway_Homo sapiens_hsa043300.60329275
93Hepatitis C_Homo sapiens_hsa051600.59391146
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57856688
95Acute myeloid leukemia_Homo sapiens_hsa052210.55553267
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54894459
97Selenocompound metabolism_Homo sapiens_hsa004500.54596257
98Influenza A_Homo sapiens_hsa051640.54136652
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52836205
100FoxO signaling pathway_Homo sapiens_hsa040680.52477035

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