ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.77835677
2	piRNA metabolic process (GO:0034587)	4.64294709
3	DNA deamination (GO:0045006)	4.46089406
4	DNA methylation involved in gamete generation (GO:0043046)	4.10731055
5	negative regulation of telomere maintenance (GO:0032205)	4.08872499
6	L-fucose catabolic process (GO:0042355)	3.98145694
7	fucose catabolic process (GO:0019317)	3.98145694
8	L-fucose metabolic process (GO:0042354)	3.98145694
9	kynurenine metabolic process (GO:0070189)	3.82300615
10	preassembly of GPI anchor in ER membrane (GO:0016254)	3.77220096
11	indolalkylamine catabolic process (GO:0046218)	3.74054792
12	tryptophan catabolic process (GO:0006569)	3.74054792
13	indole-containing compound catabolic process (GO:0042436)	3.74054792
14	meiotic chromosome segregation (GO:0045132)	3.74040026
15	response to pheromone (GO:0019236)	3.72275872
16	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.65414337
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63912292
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.52970305
19	detection of light stimulus involved in visual perception (GO:0050908)	3.52970305
20	indolalkylamine metabolic process (GO:0006586)	3.50068151
21	protein complex biogenesis (GO:0070271)	3.40606198
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.40159427
23	NADH dehydrogenase complex assembly (GO:0010257)	3.40159427
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.40159427
25	reciprocal meiotic recombination (GO:0007131)	3.38761435
26	reciprocal DNA recombination (GO:0035825)	3.38761435
27	regulation of telomere maintenance (GO:0032204)	3.33219641
28	mannosylation (GO:0097502)	3.28596478
29	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.27672956
30	respiratory chain complex IV assembly (GO:0008535)	3.27261603
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.24595279
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21255754
33	tryptophan metabolic process (GO:0006568)	3.15201681
34	male meiosis I (GO:0007141)	3.12013327
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.09647905
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.09647905
37	recombinational repair (GO:0000725)	3.09377336
38	double-strand break repair via homologous recombination (GO:0000724)	3.09229381
39	sulfation (GO:0051923)	3.07277301
40	epithelial cilium movement (GO:0003351)	3.06567318
41	replication fork processing (GO:0031297)	3.06353960
42	male meiosis (GO:0007140)	3.05963376
43	regulation of hippo signaling (GO:0035330)	3.02204681
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01139689
45	cytochrome complex assembly (GO:0017004)	3.00399043
46	cornea development in camera-type eye (GO:0061303)	3.00028111
47	negative regulation of mast cell activation (GO:0033004)	2.97794999
48	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.96639362
49	neural tube formation (GO:0001841)	2.92228361
50	regulation of meiosis I (GO:0060631)	2.90837410
51	rRNA catabolic process (GO:0016075)	2.87177674
52	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86863160
53	axoneme assembly (GO:0035082)	2.85585354
54	synapsis (GO:0007129)	2.85075225
55	pseudouridine synthesis (GO:0001522)	2.84544427
56	photoreceptor cell maintenance (GO:0045494)	2.84078239
57	protein K11-linked deubiquitination (GO:0035871)	2.83836664
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.83143121
59	regulation of mitotic spindle checkpoint (GO:1903504)	2.83143121
60	cellular ketone body metabolic process (GO:0046950)	2.83010834
61	protein-cofactor linkage (GO:0018065)	2.80915898
62	ubiquinone biosynthetic process (GO:0006744)	2.80042298
63	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.79067692
64	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.79067692
65	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.78668705
66	regulation of translation, ncRNA-mediated (GO:0045974)	2.78668705
67	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.78668705
68	amino acid salvage (GO:0043102)	2.76850410
69	L-methionine salvage (GO:0071267)	2.76850410
70	L-methionine biosynthetic process (GO:0071265)	2.76850410
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.73292362
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69172586
73	cellular response to ATP (GO:0071318)	2.68859997
74	protein polyglutamylation (GO:0018095)	2.67719413
75	cellular response to exogenous dsRNA (GO:0071360)	2.65841915
76	behavioral response to ethanol (GO:0048149)	2.64770285
77	regulation of cilium movement (GO:0003352)	2.64528970
78	protein K6-linked ubiquitination (GO:0085020)	2.61614785
79	centriole replication (GO:0007099)	2.61421286
80	platelet dense granule organization (GO:0060155)	2.60787048
81	GPI anchor metabolic process (GO:0006505)	2.60103715
82	cilium morphogenesis (GO:0060271)	2.59632612
83	endoderm formation (GO:0001706)	2.59133804
84	ubiquinone metabolic process (GO:0006743)	2.58834608
85	methionine biosynthetic process (GO:0009086)	2.57743946
86	ketone body metabolic process (GO:1902224)	2.56754175
87	peptidyl-histidine modification (GO:0018202)	2.55744261
88	positive regulation of mitochondrial fission (GO:0090141)	2.55425504
89	oxidative demethylation (GO:0070989)	2.55261840
90	tRNA processing (GO:0008033)	2.53997700
91	positive regulation of defense response to virus by host (GO:0002230)	2.53604337
92	aromatic amino acid family catabolic process (GO:0009074)	2.50067752
93	indole-containing compound metabolic process (GO:0042430)	2.49897835
94	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.49343380
95	tRNA modification (GO:0006400)	2.47259061
96	cilium or flagellum-dependent cell motility (GO:0001539)	2.47176968
97	C-terminal protein lipidation (GO:0006501)	2.46836551
98	protein prenylation (GO:0018342)	2.44446553
99	prenylation (GO:0097354)	2.44446553
100	nephron tubule morphogenesis (GO:0072078)	2.43533621

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.45471339
2	VDR_22108803_ChIP-Seq_LS180_Human	3.04932079
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.04007122
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.01867405
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.79803050
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63075016
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51921975
8	EWS_26573619_Chip-Seq_HEK293_Human	2.48905997
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.43354730
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.38861987
11	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.37530970
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.35353736
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34050474
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28001609
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27994106
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24004730
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.05385621
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98424475
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97826966
20	EZH2_22144423_ChIP-Seq_EOC_Human	1.96691204
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92628681
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.87983808
23	P300_19829295_ChIP-Seq_ESCs_Human	1.85976218
24	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85948315
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85434629
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.76469078
27	* VDR_23849224_ChIP-Seq_CD4+_Human	1.75032544
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74888857
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74798171
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.74062933
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58041765
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55586122
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55320298
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.53564042
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53437387
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.53437387
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51598467
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49984369
39	STAT3_23295773_ChIP-Seq_U87_Human	1.48437438
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.46704939
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45736850
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41065209
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.41012092
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39385980
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35859478
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35640828
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.35409179
48	HOXB7_26014856_ChIP-Seq_BT474_Human	1.35406639
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33850896
50	TCF4_23295773_ChIP-Seq_U87_Human	1.33108647
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32954790
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32954790
53	AR_25329375_ChIP-Seq_VCAP_Human	1.29268430
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28217015
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27886016
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26293601
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26177217
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25706004
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25706004
60	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25032024
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23867222
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20762827
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.20652075
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.20447447
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20170346
66	AR_20517297_ChIP-Seq_VCAP_Human	1.19273752
67	NCOR_22424771_ChIP-Seq_293T_Human	1.19069203
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18147212
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17416376
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15536937
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14135008
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14135008
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13740138
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12780287
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12621924
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.11107319
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10712791
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10631246
79	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10061018
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09074061
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07409810
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07199077
83	ERA_21632823_ChIP-Seq_H3396_Human	1.07131389
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07048539
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03719344
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01174092
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00555727
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00362504
89	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.99942916
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99734782
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99388588
92	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98569739
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98525359
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98399354
95	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97391505
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96639128
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96147929
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95958914
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95766249
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94354101

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.04460227
2	MP0008877_abnormal_DNA_methylation	2.92794713
3	MP0003136_yellow_coat_color	2.84095149
4	MP0003195_calcinosis	2.81691333
5	MP0002837_dystrophic_cardiac_calcinosis	2.76386608
6	MP0005551_abnormal_eye_electrophysiolog	2.53478167
7	MP0004043_abnormal_pH_regulation	2.43918013
8	MP0008058_abnormal_DNA_repair	2.32008857
9	MP0002102_abnormal_ear_morphology	2.18999462
10	MP0000372_irregular_coat_pigmentation	2.12777695
11	MP0006072_abnormal_retinal_apoptosis	2.07378550
12	MP0000569_abnormal_digit_pigmentation	1.98317525
13	MP0002928_abnormal_bile_duct	1.97424406
14	MP0004133_heterotaxia	1.95535844
15	MP0000427_abnormal_hair_cycle	1.94592319
16	MP0008872_abnormal_physiological_respon	1.89135633
17	MP0005253_abnormal_eye_physiology	1.88109881
18	MP0001968_abnormal_touch/_nociception	1.84448088
19	MP0005646_abnormal_pituitary_gland	1.83875333
20	MP0002138_abnormal_hepatobiliary_system	1.83613496
21	MP0002653_abnormal_ependyma_morphology	1.78588102
22	MP0004142_abnormal_muscle_tone	1.76992715
23	MP0004147_increased_porphyrin_level	1.72600613
24	MP0002876_abnormal_thyroid_physiology	1.68589562
25	MP0001986_abnormal_taste_sensitivity	1.64976278
26	MP0006292_abnormal_olfactory_placode	1.64537282
27	MP0005171_absent_coat_pigmentation	1.61003716
28	MP0005084_abnormal_gallbladder_morpholo	1.59315207
29	MP0008875_abnormal_xenobiotic_pharmacok	1.58484356
30	MP0005645_abnormal_hypothalamus_physiol	1.57307992
31	MP0002736_abnormal_nociception_after	1.54411764
32	MP0003890_abnormal_embryonic-extraembry	1.54406523
33	MP0005174_abnormal_tail_pigmentation	1.53459644
34	MP0009046_muscle_twitch	1.49263071
35	MP0002160_abnormal_reproductive_system	1.45648499
36	MP0002938_white_spotting	1.45509307
37	MP0002638_abnormal_pupillary_reflex	1.45216293
38	MP0003718_maternal_effect	1.44680809
39	MP0006276_abnormal_autonomic_nervous	1.44414344
40	MP0010386_abnormal_urinary_bladder	1.42542325
41	MP0010094_abnormal_chromosome_stability	1.37912477
42	MP0000383_abnormal_hair_follicle	1.37325607
43	MP0002163_abnormal_gland_morphology	1.35147436
44	MP0005389_reproductive_system_phenotype	1.34491630
45	MP0003252_abnormal_bile_duct	1.32418350
46	MP0009745_abnormal_behavioral_response	1.31577489
47	MP0000631_abnormal_neuroendocrine_gland	1.29481794
48	MP0002277_abnormal_respiratory_mucosa	1.29279412
49	MP0008995_early_reproductive_senescence	1.28290482
50	MP0003786_premature_aging	1.27276437
51	MP0005075_abnormal_melanosome_morpholog	1.24384606
52	MP0001485_abnormal_pinna_reflex	1.23677958
53	MP0002272_abnormal_nervous_system	1.22200606
54	MP0003011_delayed_dark_adaptation	1.21326842
55	MP0002095_abnormal_skin_pigmentation	1.17701558
56	MP0003693_abnormal_embryo_hatching	1.16608089
57	MP0005220_abnormal_exocrine_pancreas	1.16145211
58	MP0004145_abnormal_muscle_electrophysio	1.14141207
59	MP0001919_abnormal_reproductive_system	1.12169026
60	MP0001764_abnormal_homeostasis	1.10461556
61	MP0002210_abnormal_sex_determination	1.10419759
62	MP0001501_abnormal_sleep_pattern	1.08303476
63	MP0001929_abnormal_gametogenesis	1.07574775
64	MP0004885_abnormal_endolymph	1.06642231
65	MP0003698_abnormal_male_reproductive	1.05187574
66	MP0006035_abnormal_mitochondrial_morpho	1.03446869
67	MP0001984_abnormal_olfaction	1.03324296
68	MP0005332_abnormal_amino_acid	1.02442630
69	MP0001324_abnormal_eye_pigmentation	1.00438015
70	MP0008057_abnormal_DNA_replication	0.98187436
71	MP0005195_abnormal_posterior_eye	0.98028616
72	MP0001486_abnormal_startle_reflex	0.96587630
73	MP0002557_abnormal_social/conspecific_i	0.94288218
74	MP0002735_abnormal_chemical_nociception	0.93645068
75	MP0003119_abnormal_digestive_system	0.93503243
76	MP0000653_abnormal_sex_gland	0.91497281
77	MP0005410_abnormal_fertilization	0.91491921
78	MP0008775_abnormal_heart_ventricle	0.91128192
79	MP0003937_abnormal_limbs/digits/tail_de	0.90330983
80	MP0008961_abnormal_basal_metabolism	0.90110145
81	MP0003943_abnormal_hepatobiliary_system	0.88618915
82	MP0002572_abnormal_emotion/affect_behav	0.86938116
83	MP0005083_abnormal_biliary_tract	0.86028378
84	MP0001661_extended_life_span	0.85991258
85	MP0003283_abnormal_digestive_organ	0.85168850
86	MP0001145_abnormal_male_reproductive	0.85073914
87	MP0001970_abnormal_pain_threshold	0.83543859
88	MP0000647_abnormal_sebaceous_gland	0.82422825
89	MP0000538_abnormal_urinary_bladder	0.82237792
90	MP0005379_endocrine/exocrine_gland_phen	0.82112647
91	MP0003137_abnormal_impulse_conducting	0.79043655
92	MP0005085_abnormal_gallbladder_physiolo	0.78499482
93	MP0001119_abnormal_female_reproductive	0.78053243
94	MP0000015_abnormal_ear_pigmentation	0.77997676
95	MP0000230_abnormal_systemic_arterial	0.77864422
96	MP0002751_abnormal_autonomic_nervous	0.77199884
97	MP0005386_behavior/neurological_phenoty	0.76722921
98	MP0004924_abnormal_behavior	0.76722921
99	MP0002733_abnormal_thermal_nociception	0.73903721
100	MP0006036_abnormal_mitochondrial_physio	0.73857362

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.48061628
2	Congenital stationary night blindness (HP:0007642)	3.95780784
3	Pancreatic fibrosis (HP:0100732)	3.66091493
4	Abnormality of midbrain morphology (HP:0002418)	3.65640632
5	Molar tooth sign on MRI (HP:0002419)	3.65640632
6	Abnormality of the renal cortex (HP:0011035)	3.45628030
7	Nephronophthisis (HP:0000090)	3.44652819
8	True hermaphroditism (HP:0010459)	3.33271634
9	Type II lissencephaly (HP:0007260)	3.25999060
10	Abnormality of the renal medulla (HP:0100957)	3.25659285
11	Attenuation of retinal blood vessels (HP:0007843)	2.90949468
12	Medial flaring of the eyebrow (HP:0010747)	2.81662612
13	Abnormality of alanine metabolism (HP:0010916)	2.77255634
14	Hyperalaninemia (HP:0003348)	2.77255634
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.77255634
16	Pendular nystagmus (HP:0012043)	2.74138141
17	Tubular atrophy (HP:0000092)	2.67914210
18	Abolished electroretinogram (ERG) (HP:0000550)	2.59224604
19	Decreased central vision (HP:0007663)	2.54487730
20	Cystic liver disease (HP:0006706)	2.50796876
21	Hyperventilation (HP:0002883)	2.49710399
22	Renal cortical cysts (HP:0000803)	2.46255994
23	Progressive inability to walk (HP:0002505)	2.44363338
24	Chronic hepatic failure (HP:0100626)	2.44314539
25	Cerebellar dysplasia (HP:0007033)	2.42165479
26	Abnormality of the pons (HP:0007361)	2.40581548
27	Lissencephaly (HP:0001339)	2.40446220
28	Patellar aplasia (HP:0006443)	2.39262333
29	Hypoplasia of the pons (HP:0012110)	2.34072623
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.33442855
31	Polydipsia (HP:0001959)	2.32935525
32	Abnormal drinking behavior (HP:0030082)	2.32935525
33	Increased CSF lactate (HP:0002490)	2.29689062
34	Aplasia/Hypoplasia of the patella (HP:0006498)	2.29673142
35	Congenital hepatic fibrosis (HP:0002612)	2.25955583
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.25639438
37	Mitochondrial inheritance (HP:0001427)	2.21373390
38	Gaze-evoked nystagmus (HP:0000640)	2.19676027
39	Lipid accumulation in hepatocytes (HP:0006561)	2.18898974
40	Acute necrotizing encephalopathy (HP:0006965)	2.18733802
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17402954
42	Methylmalonic acidemia (HP:0002912)	2.16377577
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15340035
44	Genetic anticipation (HP:0003743)	2.14238304
45	Gait imbalance (HP:0002141)	2.13260405
46	Nephrogenic diabetes insipidus (HP:0009806)	2.12646183
47	Congenital primary aphakia (HP:0007707)	2.11866256
48	Colon cancer (HP:0003003)	2.11025210
49	Sclerocornea (HP:0000647)	2.09946660
50	Concave nail (HP:0001598)	2.08168714
51	Methylmalonic aciduria (HP:0012120)	2.06217226
52	Inability to walk (HP:0002540)	2.04552328
53	Birth length less than 3rd percentile (HP:0003561)	2.04506605
54	Keratoconus (HP:0000563)	2.03498036
55	Increased corneal curvature (HP:0100692)	2.03498036
56	Abnormality of DNA repair (HP:0003254)	2.01182650
57	Hepatocellular necrosis (HP:0001404)	2.01121450
58	Acute encephalopathy (HP:0006846)	1.98770491
59	Polyuria (HP:0000103)	1.98684506
60	Abnormal biliary tract physiology (HP:0012439)	1.98404912
61	Bile duct proliferation (HP:0001408)	1.98404912
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97432591
63	Abnormality of the ileum (HP:0001549)	1.94740757
64	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94687284
65	Protruding tongue (HP:0010808)	1.94541853
66	Abnormality of the renal collecting system (HP:0004742)	1.94435627
67	Absent/shortened dynein arms (HP:0200106)	1.94312844
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94312844
69	Retinal dysplasia (HP:0007973)	1.92815506
70	Small hand (HP:0200055)	1.92718209
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92542373
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.92542373
73	Abnormal protein glycosylation (HP:0012346)	1.92542373
74	Abnormal glycosylation (HP:0012345)	1.92542373
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92359025
76	Hepatic necrosis (HP:0002605)	1.92153149
77	Meckel diverticulum (HP:0002245)	1.92152474
78	Decreased circulating renin level (HP:0003351)	1.91508920
79	Clumsiness (HP:0002312)	1.91480311
80	Tubulointerstitial nephritis (HP:0001970)	1.89730065
81	Absent thumb (HP:0009777)	1.89369000
82	Type I transferrin isoform profile (HP:0003642)	1.88886204
83	Optic disc pallor (HP:0000543)	1.86982739
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.86773595
85	Sloping forehead (HP:0000340)	1.86336641
86	Progressive macrocephaly (HP:0004481)	1.84573493
87	Anencephaly (HP:0002323)	1.84395305
88	Increased serum lactate (HP:0002151)	1.84362896
89	Enlarged kidneys (HP:0000105)	1.84161247
90	Chorioretinal atrophy (HP:0000533)	1.83484609
91	Congenital, generalized hypertrichosis (HP:0004540)	1.80794375
92	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.78318653
93	Furrowed tongue (HP:0000221)	1.77391386
94	Stomach cancer (HP:0012126)	1.77190489
95	Oligohydramnios (HP:0001562)	1.76659104
96	Chromsome breakage (HP:0040012)	1.75959224
97	Large for gestational age (HP:0001520)	1.75620023
98	Severe muscular hypotonia (HP:0006829)	1.74965715
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.74835218
100	Clubbing of toes (HP:0100760)	1.72875907

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.90848717
2	BMPR1B	3.63933073
3	ACVR1B	3.26714515
4	ZAK	3.16849846
5	ADRBK2	2.75771564
6	WNK4	2.57169092
7	TAOK3	2.45331115
8	GRK1	2.44829661
9	TLK1	2.35380291
10	NUAK1	2.24321842
11	WNK3	2.08550833
12	INSRR	2.05705052
13	PINK1	2.00125893
14	MAP4K2	1.91765638
15	MKNK2	1.68143029
16	STK39	1.65347064
17	OXSR1	1.63606052
18	TRIM28	1.55653038
19	BRSK2	1.49145353
20	MAPK13	1.45261986
21	MST4	1.44337240
22	MAP3K4	1.39700415
23	STK38L	1.28517701
24	PNCK	1.28478455
25	AKT3	1.21915868
26	ADRBK1	1.21470489
27	WEE1	1.20905032
28	CASK	1.17621152
29	MAPKAPK3	1.13861234
30	TGFBR1	1.07707464
31	MAPK15	1.06064038
32	BCKDK	1.02538845
33	PDK2	0.98938345
34	LMTK2	0.95990901
35	VRK1	0.95674772
36	DAPK2	0.93601540
37	MAP2K7	0.89042817
38	STK16	0.88956273
39	PIK3CA	0.87925568
40	PLK4	0.87539050
41	MUSK	0.87198691
42	SRPK1	0.86148567
43	MELK	0.81587299
44	TXK	0.81007868
45	NME1	0.80420560
46	ATR	0.80369846
47	CAMKK2	0.79369345
48	MAP2K6	0.76730183
49	DYRK2	0.73884940
50	FLT3	0.72517683
51	LATS1	0.67276719
52	BCR	0.66441488
53	PAK3	0.66140796
54	IKBKB	0.66130763
55	PRKCQ	0.65393193
56	PTK2B	0.65160552
57	PRKCE	0.65120819
58	PLK1	0.64623580
59	MKNK1	0.64168683
60	CSNK1A1L	0.62891127
61	MAP2K2	0.62338244
62	CDC7	0.62210408
63	TNIK	0.61129803
64	NEK2	0.59693124
65	CHEK2	0.59057599
66	STK3	0.58971599
67	STK11	0.57995946
68	PRKCG	0.56450337
69	RPS6KA5	0.56355366
70	EIF2AK3	0.55392255
71	TEC	0.53994945
72	SIK2	0.53805387
73	NLK	0.53124859
74	VRK2	0.52642983
75	TAF1	0.50492299
76	CSNK1G2	0.50252854
77	CSNK1G1	0.49034019
78	PLK3	0.48954713
79	ERBB3	0.48230878
80	PRKCI	0.46916682
81	ATM	0.46461789
82	CDK19	0.45556050
83	MARK3	0.44394482
84	PHKG2	0.42491335
85	PHKG1	0.42491335
86	CSNK1G3	0.42336305
87	GRK7	0.41905471
88	CDK8	0.40189779
89	KIT	0.39996250
90	TNK2	0.39858722
91	PRKACA	0.37255543
92	PLK2	0.37083601
93	CCNB1	0.35688143
94	CHUK	0.33688439
95	CAMK2A	0.32172897
96	PRKAA1	0.31867503
97	OBSCN	0.31220801
98	PIM1	0.28088555
99	MAPKAPK5	0.26881171
100	CSNK1A1	0.26639012

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.84370669
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.82004196
3	Homologous recombination_Homo sapiens_hsa03440	2.76177202
4	Phototransduction_Homo sapiens_hsa04744	2.62589370
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48329965
6	RNA polymerase_Homo sapiens_hsa03020	2.23484360
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.23306507
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.19689993
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05480013
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00115848
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99438983
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96311754
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95764268
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.91171129
15	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.84119007
16	One carbon pool by folate_Homo sapiens_hsa00670	1.80913491
17	Basal transcription factors_Homo sapiens_hsa03022	1.80010056
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79177874
19	Nicotine addiction_Homo sapiens_hsa05033	1.77782748
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.77437223
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.73690669
22	Butanoate metabolism_Homo sapiens_hsa00650	1.69075693
23	Protein export_Homo sapiens_hsa03060	1.63053726
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.59282164
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.51649702
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48257264
27	RNA degradation_Homo sapiens_hsa03018	1.45859951
28	Parkinsons disease_Homo sapiens_hsa05012	1.45828204
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44219360
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.43327391
31	Taste transduction_Homo sapiens_hsa04742	1.39552999
32	Propanoate metabolism_Homo sapiens_hsa00640	1.37432864
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33081649
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.32951806
35	Peroxisome_Homo sapiens_hsa04146	1.21930618
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19326531
37	Caffeine metabolism_Homo sapiens_hsa00232	1.19174898
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13973801
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13013205
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11447905
41	Sulfur relay system_Homo sapiens_hsa04122	1.10555654
42	Huntingtons disease_Homo sapiens_hsa05016	1.08085970
43	ABC transporters_Homo sapiens_hsa02010	1.06108062
44	Morphine addiction_Homo sapiens_hsa05032	1.04978173
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04523969
46	Regulation of autophagy_Homo sapiens_hsa04140	1.03653908
47	Olfactory transduction_Homo sapiens_hsa04740	1.00022709
48	Proteasome_Homo sapiens_hsa03050	0.98499148
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98003372
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.96713191
51	Purine metabolism_Homo sapiens_hsa00230	0.95980931
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90927607
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87894858
54	Retinol metabolism_Homo sapiens_hsa00830	0.86002602
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83413786
56	Mismatch repair_Homo sapiens_hsa03430	0.82854669
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82780677
58	Alzheimers disease_Homo sapiens_hsa05010	0.81240675
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79079101
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72494221
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71687512
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71402870
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70426276
64	RNA transport_Homo sapiens_hsa03013	0.69966324
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69565978
66	GABAergic synapse_Homo sapiens_hsa04727	0.68610322
67	Circadian rhythm_Homo sapiens_hsa04710	0.68003215
68	Metabolic pathways_Homo sapiens_hsa01100	0.67746579
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66392802
70	Base excision repair_Homo sapiens_hsa03410	0.62832526
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.61018808
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60767009
73	Sulfur metabolism_Homo sapiens_hsa00920	0.59556516
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58407433
75	Serotonergic synapse_Homo sapiens_hsa04726	0.56184649
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56027589
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55762870
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53625625
79	Histidine metabolism_Homo sapiens_hsa00340	0.52731832
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52505617
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.51715059
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50205521
83	Fatty acid degradation_Homo sapiens_hsa00071	0.50013661
84	Asthma_Homo sapiens_hsa05310	0.49174894
85	Circadian entrainment_Homo sapiens_hsa04713	0.47682970
86	Lysine degradation_Homo sapiens_hsa00310	0.47356158
87	Insulin secretion_Homo sapiens_hsa04911	0.47117027
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.44770714
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41744396
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40948386
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40454967
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38925189
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38659018
94	Salivary secretion_Homo sapiens_hsa04970	0.37982247
95	p53 signaling pathway_Homo sapiens_hsa04115	0.37266562
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37216091
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.36789157
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36594721
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.36392265
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34114137

ZNF7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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