ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.10201112
2	fucose catabolic process (GO:0019317)	4.20841007
3	L-fucose metabolic process (GO:0042354)	4.20841007
4	L-fucose catabolic process (GO:0042355)	4.20841007
5	DNA deamination (GO:0045006)	3.92850511
6	sulfation (GO:0051923)	3.90746290
7	kynurenine metabolic process (GO:0070189)	3.89634814
8	tryptophan catabolic process (GO:0006569)	3.82569325
9	indole-containing compound catabolic process (GO:0042436)	3.82569325
10	indolalkylamine catabolic process (GO:0046218)	3.82569325
11	gamma-aminobutyric acid transport (GO:0015812)	3.73298713
12	cellular response to ATP (GO:0071318)	3.65862158
13	negative regulation of mast cell activation (GO:0033004)	3.64935389
14	indolalkylamine metabolic process (GO:0006586)	3.59492206
15	negative regulation of telomere maintenance (GO:0032205)	3.46766267
16	kidney morphogenesis (GO:0060993)	3.42416118
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.34638140
18	response to pheromone (GO:0019236)	3.28401059
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.27737554
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23986781
21	neuronal action potential (GO:0019228)	3.21548575
22	tryptophan metabolic process (GO:0006568)	3.20929139
23	detection of light stimulus involved in visual perception (GO:0050908)	3.15127947
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.15127947
25	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.11794510
26	regulation of hippo signaling (GO:0035330)	3.07129754
27	somite development (GO:0061053)	3.06736685
28	platelet dense granule organization (GO:0060155)	3.06674886
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05394942
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05394942
31	NADH dehydrogenase complex assembly (GO:0010257)	3.05394942
32	regulation of posttranscriptional gene silencing (GO:0060147)	3.04231136
33	regulation of gene silencing by miRNA (GO:0060964)	3.04231136
34	regulation of gene silencing by RNA (GO:0060966)	3.04231136
35	reflex (GO:0060004)	3.03487559
36	primary amino compound metabolic process (GO:1901160)	3.02846898
37	indole-containing compound metabolic process (GO:0042430)	3.02193185
38	protein polyglutamylation (GO:0018095)	3.02106444
39	regulation of action potential (GO:0098900)	3.01597708
40	nephron epithelium morphogenesis (GO:0072088)	3.00226572
41	nephron tubule morphogenesis (GO:0072078)	3.00226572
42	piRNA metabolic process (GO:0034587)	2.99705501
43	peristalsis (GO:0030432)	2.94175877
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.93918588
45	cornea development in camera-type eye (GO:0061303)	2.93278384
46	serotonin metabolic process (GO:0042428)	2.92706465
47	nonmotile primary cilium assembly (GO:0035058)	2.87288289
48	regulation of mesoderm development (GO:2000380)	2.86106646
49	protein complex biogenesis (GO:0070271)	2.85919232
50	ubiquinone biosynthetic process (GO:0006744)	2.82486805
51	cellular ketone body metabolic process (GO:0046950)	2.80216695
52	epithelial cilium movement (GO:0003351)	2.78486830
53	spinal cord motor neuron differentiation (GO:0021522)	2.75879847
54	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.75246150
55	regulation of translation, ncRNA-mediated (GO:0045974)	2.75246150
56	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.75246150
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74715343
58	endoderm formation (GO:0001706)	2.74360307
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.73636904
60	protein-cofactor linkage (GO:0018065)	2.70118787
61	cellular biogenic amine catabolic process (GO:0042402)	2.70089474
62	amine catabolic process (GO:0009310)	2.70089474
63	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.69797845
64	ubiquinone metabolic process (GO:0006743)	2.66944959
65	positive regulation of fatty acid oxidation (GO:0046321)	2.65301760
66	reciprocal DNA recombination (GO:0035825)	2.64798400
67	reciprocal meiotic recombination (GO:0007131)	2.64798400
68	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.63637828
69	cell proliferation in forebrain (GO:0021846)	2.62350371
70	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.62064809
71	negative regulation of multicellular organism growth (GO:0040015)	2.61195088
72	protein import into peroxisome matrix (GO:0016558)	2.61099652
73	rhodopsin mediated signaling pathway (GO:0016056)	2.59747843
74	phasic smooth muscle contraction (GO:0014821)	2.59296260
75	neural tube formation (GO:0001841)	2.59054202
76	negative regulation of systemic arterial blood pressure (GO:0003085)	2.58848171
77	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.57608020
78	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.57608020
79	positive regulation of fatty acid transport (GO:2000193)	2.56521253
80	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.55747982
81	positive regulation of defense response to virus by host (GO:0002230)	2.55211726
82	behavioral response to ethanol (GO:0048149)	2.54596261
83	axoneme assembly (GO:0035082)	2.53920070
84	male meiosis I (GO:0007141)	2.53600094
85	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.52681483
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.51005490
87	regulation of telomere maintenance (GO:0032204)	2.50895934
88	pseudouridine synthesis (GO:0001522)	2.50304138
89	ketone body metabolic process (GO:1902224)	2.49186223
90	recombinational repair (GO:0000725)	2.47648111
91	head development (GO:0060322)	2.46751031
92	cilium morphogenesis (GO:0060271)	2.46479112
93	somite rostral/caudal axis specification (GO:0032525)	2.46460372
94	double-strand break repair via homologous recombination (GO:0000724)	2.44871386
95	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.44005031
96	regulation of hexokinase activity (GO:1903299)	2.43452914
97	regulation of glucokinase activity (GO:0033131)	2.43452914
98	renal tubule morphogenesis (GO:0061333)	2.41607978
99	DNA methylation involved in gamete generation (GO:0043046)	2.41429756
100	cellular response to exogenous dsRNA (GO:0071360)	2.41262172

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.14339845
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.49866557
3	VDR_22108803_ChIP-Seq_LS180_Human	3.42454927
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.87583828
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.84813038
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71328243
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.46523049
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40064042
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14767328
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13343199
11	EWS_26573619_Chip-Seq_HEK293_Human	2.11871209
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00502938
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99223265
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99216143
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.94600161
16	FUS_26573619_Chip-Seq_HEK293_Human	1.91434846
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.91344769
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85871921
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85838602
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.80308159
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77947016
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76777947
23	P300_19829295_ChIP-Seq_ESCs_Human	1.71624248
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71111511
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70265015
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.68736326
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67018305
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59331077
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.58139662
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57082098
31	STAT3_23295773_ChIP-Seq_U87_Human	1.52834827
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52707363
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.49741866
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.48625412
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48482786
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47349682
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47044423
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.47029842
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43965718
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43579511
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43013177
42	TCF4_23295773_ChIP-Seq_U87_Human	1.41854155
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39210711
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39210711
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38051202
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38051202
47	AR_25329375_ChIP-Seq_VCAP_Human	1.37942890
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37380813
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35425404
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34173098
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34134457
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.31706990
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31706990
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.31178470
55	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30596587
56	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29494497
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28017880
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27826015
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25785575
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23831407
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23246943
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22462274
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22462274
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22080868
65	NCOR_22424771_ChIP-Seq_293T_Human	1.20608365
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20178798
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19262470
68	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17110735
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16949228
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.15728109
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15086497
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13248283
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12718230
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11765539
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11347488
76	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10927341
77	TP53_16413492_ChIP-PET_HCT116_Human	1.10433989
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10041194
79	AR_20517297_ChIP-Seq_VCAP_Human	1.09501442
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08646495
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08567161
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08505358
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.07308269
84	DROSHA_22980978_ChIP-Seq_HELA_Human	1.07288910
85	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06820930
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05920089
87	* ERA_21632823_ChIP-Seq_H3396_Human	1.05859174
88	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.02219390
89	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02106535
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01264807
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00409487
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98717099
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98251273
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97496240
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96887847
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96218766
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95810361
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95585276
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94620466
100	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.93452619

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.98605301
2	MP0003646_muscle_fatigue	2.71776371
3	MP0002102_abnormal_ear_morphology	2.52015794
4	MP0008877_abnormal_DNA_methylation	2.39843602
5	MP0003283_abnormal_digestive_organ	2.35978128
6	MP0005551_abnormal_eye_electrophysiolog	2.33733946
7	MP0000569_abnormal_digit_pigmentation	2.33665825
8	MP0001968_abnormal_touch/_nociception	2.30100270
9	MP0009046_muscle_twitch	2.29699044
10	MP0001986_abnormal_taste_sensitivity	2.22323298
11	MP0002837_dystrophic_cardiac_calcinosis	2.06708775
12	MP0003136_yellow_coat_color	2.06304377
13	MP0005646_abnormal_pituitary_gland	2.04293973
14	MP0008872_abnormal_physiological_respon	2.03691536
15	MP0002876_abnormal_thyroid_physiology	2.02683119
16	MP0004147_increased_porphyrin_level	2.00155723
17	MP0006292_abnormal_olfactory_placode	1.99621756
18	MP0004133_heterotaxia	1.95682354
19	MP0004885_abnormal_endolymph	1.95386013
20	MP0002638_abnormal_pupillary_reflex	1.92559763
21	MP0009745_abnormal_behavioral_response	1.88667662
22	MP0002735_abnormal_chemical_nociception	1.84478986
23	MP0004043_abnormal_pH_regulation	1.80187428
24	MP0003011_delayed_dark_adaptation	1.79592811
25	MP0002653_abnormal_ependyma_morphology	1.79249640
26	MP0005645_abnormal_hypothalamus_physiol	1.77864920
27	MP0004142_abnormal_muscle_tone	1.76127696
28	MP0002736_abnormal_nociception_after	1.74269446
29	MP0001485_abnormal_pinna_reflex	1.71029546
30	MP0002160_abnormal_reproductive_system	1.68944133
31	MP0004145_abnormal_muscle_electrophysio	1.65546817
32	MP0002272_abnormal_nervous_system	1.65468887
33	MP0006072_abnormal_retinal_apoptosis	1.65085674
34	MP0000631_abnormal_neuroendocrine_gland	1.64500971
35	MP0003890_abnormal_embryonic-extraembry	1.61297067
36	MP0005253_abnormal_eye_physiology	1.60421080
37	MP0002938_white_spotting	1.59593982
38	MP0005174_abnormal_tail_pigmentation	1.59171630
39	MP0000427_abnormal_hair_cycle	1.54286409
40	MP0008875_abnormal_xenobiotic_pharmacok	1.49053445
41	MP0002733_abnormal_thermal_nociception	1.47789632
42	MP0004742_abnormal_vestibular_system	1.37012945
43	MP0002928_abnormal_bile_duct	1.36518562
44	MP0001501_abnormal_sleep_pattern	1.36137916
45	MP0005389_reproductive_system_phenotype	1.35451302
46	MP0005084_abnormal_gallbladder_morpholo	1.35367436
47	MP0000383_abnormal_hair_follicle	1.34080456
48	MP0002064_seizures	1.30368467
49	MP0004130_abnormal_muscle_cell	1.29250233
50	MP0001970_abnormal_pain_threshold	1.27987736
51	MP0001486_abnormal_startle_reflex	1.26750243
52	MP0004924_abnormal_behavior	1.23062490
53	MP0005386_behavior/neurological_phenoty	1.23062490
54	MP0002572_abnormal_emotion/affect_behav	1.22423228
55	MP0002234_abnormal_pharynx_morphology	1.21759321
56	MP0006276_abnormal_autonomic_nervous	1.21510993
57	MP0000049_abnormal_middle_ear	1.19939545
58	MP0002067_abnormal_sensory_capabilities	1.16013199
59	MP0002557_abnormal_social/conspecific_i	1.16001857
60	MP0003119_abnormal_digestive_system	1.15136071
61	MP0003787_abnormal_imprinting	1.07737323
62	MP0002734_abnormal_mechanical_nocicepti	1.06355540
63	MP0000372_irregular_coat_pigmentation	1.06272434
64	MP0003252_abnormal_bile_duct	1.06000731
65	MP0005195_abnormal_posterior_eye	1.05094466
66	MP0002751_abnormal_autonomic_nervous	1.03731717
67	MP0000230_abnormal_systemic_arterial	1.03556600
68	MP0002063_abnormal_learning/memory/cond	0.99106513
69	MP0003880_abnormal_central_pattern	0.98483782
70	MP0003635_abnormal_synaptic_transmissio	0.94620643
71	MP0003718_maternal_effect	0.94232561
72	MP0003137_abnormal_impulse_conducting	0.93304608
73	MP0000026_abnormal_inner_ear	0.91697399
74	MP0001502_abnormal_circadian_rhythm	0.91491744
75	MP0002095_abnormal_skin_pigmentation	0.90700651
76	MP0008995_early_reproductive_senescence	0.89305377
77	MP0003937_abnormal_limbs/digits/tail_de	0.88633123
78	MP0002752_abnormal_somatic_nervous	0.87696398
79	MP0001919_abnormal_reproductive_system	0.85230792
80	MP0002282_abnormal_trachea_morphology	0.84335225
81	MP0010386_abnormal_urinary_bladder	0.83799271
82	MP0008775_abnormal_heart_ventricle	0.82619190
83	MP0001905_abnormal_dopamine_level	0.82104037
84	MP0004215_abnormal_myocardial_fiber	0.81698817
85	MP0002277_abnormal_respiratory_mucosa	0.80837620
86	MP0003938_abnormal_ear_development	0.78866924
87	MP0005167_abnormal_blood-brain_barrier	0.78750035
88	MP0001984_abnormal_olfaction	0.77917239
89	MP0005448_abnormal_energy_balance	0.77382715
90	MP0002184_abnormal_innervation	0.76752521
91	MP0000778_abnormal_nervous_system	0.76020873
92	MP0009250_abnormal_appendicular_skeleto	0.75372842
93	MP0001963_abnormal_hearing_physiology	0.73122164
94	MP0001324_abnormal_eye_pigmentation	0.72808209
95	MP0003698_abnormal_male_reproductive	0.72718279
96	MP0002163_abnormal_gland_morphology	0.71055134
97	MP0001440_abnormal_grooming_behavior	0.70210082
98	MP0005171_absent_coat_pigmentation	0.70176580
99	MP0008961_abnormal_basal_metabolism	0.69793967
100	MP0000538_abnormal_urinary_bladder	0.69762235

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.67780849
2	Congenital stationary night blindness (HP:0007642)	4.28396273
3	Abnormality of midbrain morphology (HP:0002418)	4.26013617
4	Molar tooth sign on MRI (HP:0002419)	4.26013617
5	Genetic anticipation (HP:0003743)	4.19454747
6	Pancreatic fibrosis (HP:0100732)	4.15715277
7	True hermaphroditism (HP:0010459)	4.01724750
8	Pendular nystagmus (HP:0012043)	3.57394095
9	Nephronophthisis (HP:0000090)	3.53660289
10	Hyperventilation (HP:0002883)	3.45231770
11	Birth length less than 3rd percentile (HP:0003561)	3.44611171
12	Type II lissencephaly (HP:0007260)	3.41244379
13	Progressive cerebellar ataxia (HP:0002073)	3.26931783
14	Abnormality of alanine metabolism (HP:0010916)	3.08295583
15	Hyperalaninemia (HP:0003348)	3.08295583
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.08295583
17	Abnormality of the renal medulla (HP:0100957)	3.07312696
18	Abnormality of the renal cortex (HP:0011035)	3.05416190
19	Abolished electroretinogram (ERG) (HP:0000550)	2.94623826
20	Cystic liver disease (HP:0006706)	2.93439804
21	Attenuation of retinal blood vessels (HP:0007843)	2.90779597
22	Tubular atrophy (HP:0000092)	2.78506369
23	Gaze-evoked nystagmus (HP:0000640)	2.73837154
24	Keratoconus (HP:0000563)	2.72951298
25	Increased corneal curvature (HP:0100692)	2.72951298
26	Large for gestational age (HP:0001520)	2.72132637
27	Inability to walk (HP:0002540)	2.71813102
28	Patellar aplasia (HP:0006443)	2.70707239
29	Medial flaring of the eyebrow (HP:0010747)	2.68301014
30	Aplasia/Hypoplasia of the patella (HP:0006498)	2.65519898
31	Chronic hepatic failure (HP:0100626)	2.58620099
32	Furrowed tongue (HP:0000221)	2.49723519
33	Sclerocornea (HP:0000647)	2.48734015
34	Congenital, generalized hypertrichosis (HP:0004540)	2.48105338
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.42879973
36	Cerebellar dysplasia (HP:0007033)	2.41305834
37	Chorioretinal atrophy (HP:0000533)	2.39822715
38	Abnormal drinking behavior (HP:0030082)	2.39795767
39	Polydipsia (HP:0001959)	2.39795767
40	Concave nail (HP:0001598)	2.36813465
41	Decreased central vision (HP:0007663)	2.34499017
42	Protruding tongue (HP:0010808)	2.33656852
43	Clumsiness (HP:0002312)	2.30769367
44	Progressive inability to walk (HP:0002505)	2.29380354
45	Lissencephaly (HP:0001339)	2.27582880
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.26350797
47	Anencephaly (HP:0002323)	2.18706549
48	Abnormality of the renal collecting system (HP:0004742)	2.17340024
49	Abnormality of the pons (HP:0007361)	2.16925406
50	Broad-based gait (HP:0002136)	2.15536661
51	Gait imbalance (HP:0002141)	2.11593900
52	Male pseudohermaphroditism (HP:0000037)	2.10210136
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08514913
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08319232
55	Hemiparesis (HP:0001269)	2.06843176
56	Hypoplasia of the pons (HP:0012110)	2.06793397
57	Congenital primary aphakia (HP:0007707)	2.06402018
58	Severe muscular hypotonia (HP:0006829)	2.05864582
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05213402
60	Absent/shortened dynein arms (HP:0200106)	2.05213402
61	Abnormal biliary tract physiology (HP:0012439)	2.05049262
62	Bile duct proliferation (HP:0001408)	2.05049262
63	Congenital hepatic fibrosis (HP:0002612)	2.03154019
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99273561
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97707466
66	Congenital sensorineural hearing impairment (HP:0008527)	1.97392819
67	Renal cortical cysts (HP:0000803)	1.96249758
68	Microretrognathia (HP:0000308)	1.94697763
69	Agitation (HP:0000713)	1.94382808
70	Nephrogenic diabetes insipidus (HP:0009806)	1.92142866
71	Tachypnea (HP:0002789)	1.88783047
72	Duplicated collecting system (HP:0000081)	1.87464887
73	Decreased circulating renin level (HP:0003351)	1.86937364
74	Breast hypoplasia (HP:0003187)	1.86511248
75	Fair hair (HP:0002286)	1.84356326
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84340674
77	Retinal dysplasia (HP:0007973)	1.83678477
78	Polyuria (HP:0000103)	1.83407443
79	Mesangial abnormality (HP:0001966)	1.83233533
80	Postaxial foot polydactyly (HP:0001830)	1.81407469
81	3-Methylglutaconic aciduria (HP:0003535)	1.79883920
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.79120130
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79120130
84	Stomach cancer (HP:0012126)	1.79078256
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.77344417
86	Optic nerve hypoplasia (HP:0000609)	1.75440649
87	Bilateral microphthalmos (HP:0007633)	1.75360859
88	Genital tract atresia (HP:0001827)	1.75057641
89	Methylmalonic acidemia (HP:0002912)	1.74595820
90	Vaginal atresia (HP:0000148)	1.74172479
91	Absent thumb (HP:0009777)	1.72820525
92	Impaired smooth pursuit (HP:0007772)	1.71369266
93	Febrile seizures (HP:0002373)	1.70161127
94	Abnormal number of erythroid precursors (HP:0012131)	1.69449946
95	Pachygyria (HP:0001302)	1.68011189
96	Small hand (HP:0200055)	1.67452803
97	Rib fusion (HP:0000902)	1.66549151
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.66293270
99	Absent speech (HP:0001344)	1.65562689
100	Abnormality of DNA repair (HP:0003254)	1.63700888

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.53091727
2	BMPR1B	3.91376067
3	ADRBK2	3.81638204
4	ACVR1B	3.51559966
5	GRK1	3.23824205
6	WNK4	2.80221985
7	ZAK	2.76718142
8	TLK1	2.52038647
9	INSRR	2.46704491
10	PINK1	2.40538720
11	WNK3	2.12904692
12	MAP4K2	2.11602620
13	NUAK1	2.07715693
14	DAPK2	1.94931303
15	TAOK3	1.92370479
16	CASK	1.91440731
17	TGFBR1	1.72889616
18	MAPK13	1.70449005
19	MKNK2	1.50370922
20	ADRBK1	1.42484604
21	OXSR1	1.37832128
22	TXK	1.34037511
23	MAP3K4	1.32702090
24	MAPK15	1.17518162
25	PNCK	1.15080548
26	CAMKK2	1.09514770
27	MAPKAPK3	1.07831904
28	TIE1	1.03872376
29	TNIK	1.02390089
30	PTK2B	0.99016373
31	STK39	0.98849698
32	PIK3CA	0.98483822
33	KIT	0.96144614
34	PAK3	0.95607590
35	MAPKAPK5	0.91424145
36	PRKCG	0.87292556
37	DYRK2	0.81191223
38	NEK2	0.78963856
39	PRKCE	0.76228324
40	MKNK1	0.75270007
41	NTRK3	0.72084128
42	MAP2K7	0.70769815
43	VRK1	0.69959492
44	RPS6KA5	0.69801639
45	CAMK1D	0.68349447
46	TEC	0.67909014
47	MARK1	0.67809106
48	IKBKB	0.67615416
49	MAP2K6	0.65833809
50	WNK1	0.65056744
51	BRSK2	0.63589913
52	BCKDK	0.63506293
53	CSNK1G2	0.63142700
54	STK38L	0.61320795
55	IRAK1	0.60855451
56	TRPM7	0.59775836
57	STK11	0.59729971
58	CSNK1G1	0.59042555
59	AKT3	0.56812167
60	NME1	0.56772464
61	WEE1	0.56719027
62	CAMKK1	0.55238486
63	NTRK2	0.54534091
64	MUSK	0.53420513
65	CAMK2A	0.52602970
66	CAMK1	0.52409852
67	TRIM28	0.52185482
68	PRKCQ	0.51378040
69	CHUK	0.50952148
70	PKN1	0.50485083
71	CSNK1G3	0.50331571
72	OBSCN	0.49827679
73	PRKD2	0.47554211
74	RPS6KA6	0.47126964
75	PHKG2	0.46146500
76	PHKG1	0.46146500
77	CSNK1A1L	0.45812867
78	PRKACA	0.45807707
79	STK3	0.43791230
80	FGFR2	0.43530835
81	CHEK2	0.43025957
82	MAP2K1	0.42805885
83	CAMK1G	0.42536263
84	PRKAA1	0.41521606
85	FLT3	0.41487308
86	PRKAA2	0.40300718
87	ITK	0.39968446
88	CSNK1A1	0.39251632
89	TNK2	0.38876159
90	CSNK1D	0.38860438
91	PLK4	0.38284801
92	SGK2	0.37590674
93	ERBB2	0.35570778
94	PRKCI	0.34671315
95	MELK	0.33754957
96	PLK2	0.33649776
97	ATR	0.33465440
98	PRKCH	0.33392353
99	PRKCA	0.32948006
100	SIK2	0.31961744

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.04454952
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.66721095
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.58862674
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.52843408
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.50470361
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.40442991
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38946015
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.37602898
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37309798
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36867706
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18758228
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.11057462
13	Homologous recombination_Homo sapiens_hsa03440	2.05985746
14	Nicotine addiction_Homo sapiens_hsa05033	2.03970407
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00414405
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82021912
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.81294164
18	Butanoate metabolism_Homo sapiens_hsa00650	1.77751395
19	RNA polymerase_Homo sapiens_hsa03020	1.75249980
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.69251017
21	Sulfur relay system_Homo sapiens_hsa04122	1.68541991
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.60812919
23	Caffeine metabolism_Homo sapiens_hsa00232	1.60615928
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60277210
25	Taste transduction_Homo sapiens_hsa04742	1.56580158
26	Basal transcription factors_Homo sapiens_hsa03022	1.53093648
27	One carbon pool by folate_Homo sapiens_hsa00670	1.40084078
28	Morphine addiction_Homo sapiens_hsa05032	1.37881159
29	ABC transporters_Homo sapiens_hsa02010	1.32359043
30	Parkinsons disease_Homo sapiens_hsa05012	1.29815875
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29074527
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28355892
33	Olfactory transduction_Homo sapiens_hsa04740	1.27486551
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21714931
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17532832
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11876541
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09630896
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08269424
39	Insulin secretion_Homo sapiens_hsa04911	1.04214367
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03281603
41	Protein export_Homo sapiens_hsa03060	1.01926025
42	Serotonergic synapse_Homo sapiens_hsa04726	1.00586175
43	Glutamatergic synapse_Homo sapiens_hsa04724	0.99776187
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.96721464
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96604491
46	Peroxisome_Homo sapiens_hsa04146	0.96064503
47	Huntingtons disease_Homo sapiens_hsa05016	0.95327294
48	Retinol metabolism_Homo sapiens_hsa00830	0.94710083
49	GABAergic synapse_Homo sapiens_hsa04727	0.94543258
50	Circadian entrainment_Homo sapiens_hsa04713	0.93421176
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.92579818
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90643939
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89087632
54	RNA degradation_Homo sapiens_hsa03018	0.84454790
55	Alzheimers disease_Homo sapiens_hsa05010	0.84055526
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83445595
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83264399
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.82917134
59	Ribosome_Homo sapiens_hsa03010	0.81707162
60	Histidine metabolism_Homo sapiens_hsa00340	0.80058609
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75277032
62	Sulfur metabolism_Homo sapiens_hsa00920	0.73759657
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73509281
64	Propanoate metabolism_Homo sapiens_hsa00640	0.71464020
65	Salivary secretion_Homo sapiens_hsa04970	0.71223277
66	Regulation of autophagy_Homo sapiens_hsa04140	0.67225872
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66748842
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65598067
69	Purine metabolism_Homo sapiens_hsa00230	0.65470710
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.64451053
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62688940
72	Long-term depression_Homo sapiens_hsa04730	0.59562718
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59422680
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.59132519
75	Asthma_Homo sapiens_hsa05310	0.58838473
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56538814
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56001848
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54957667
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52255881
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.51047181
81	Mineral absorption_Homo sapiens_hsa04978	0.50151077
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49453255
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47638876
84	Metabolic pathways_Homo sapiens_hsa01100	0.47505387
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45463184
86	Cocaine addiction_Homo sapiens_hsa05030	0.44125608
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42151213
88	Cholinergic synapse_Homo sapiens_hsa04725	0.41051594
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.40112591
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.39693572
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37695413
92	Gastric acid secretion_Homo sapiens_hsa04971	0.33205014
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.32543776
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32068468
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31549851
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31541465
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30069820
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29567949
99	Melanoma_Homo sapiens_hsa05218	0.27547516
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26917821

ZNF70

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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