ZNF700

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA catabolic process (GO:0016075)4.86389327
2positive regulation of gamma-delta T cell activation (GO:0046645)4.48191819
3neural tube formation (GO:0001841)4.29090591
4hepatocyte apoptotic process (GO:0097284)4.19562065
5regulation of telomere maintenance via telomerase (GO:0032210)3.84163585
6neutrophil activation involved in immune response (GO:0002283)3.81119676
7regulation of B cell receptor signaling pathway (GO:0050855)3.75458854
8fucose catabolic process (GO:0019317)3.71700748
9L-fucose metabolic process (GO:0042354)3.71700748
10L-fucose catabolic process (GO:0042355)3.71700748
11positive regulation of granulocyte differentiation (GO:0030854)3.61040501
12B cell receptor signaling pathway (GO:0050853)3.49589451
13regulation of B cell differentiation (GO:0045577)3.39241011
14positive regulation of B cell differentiation (GO:0045579)3.36045055
15monoubiquitinated protein deubiquitination (GO:0035520)3.34707296
16cellular extravasation (GO:0045123)3.34216674
17prenylation (GO:0097354)3.30692869
18protein prenylation (GO:0018342)3.30692869
19DNA double-strand break processing (GO:0000729)3.19702085
20positive regulation of histone H3-K4 methylation (GO:0051571)3.18522530
21spermatid nucleus differentiation (GO:0007289)3.18201497
22negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.09506723
23gonadal mesoderm development (GO:0007506)3.07077956
24mast cell degranulation (GO:0043303)3.06992192
25mast cell activation involved in immune response (GO:0002279)3.06992192
26regulation of telomere maintenance (GO:0032204)3.03929812
27single strand break repair (GO:0000012)3.01005370
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98257432
29regulation of gamma-delta T cell activation (GO:0046643)2.95341550
30regulation of chromatin silencing (GO:0031935)2.95175816
31mast cell activation (GO:0045576)2.91569297
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90587771
33neutrophil activation (GO:0042119)2.86869616
34histone mRNA catabolic process (GO:0071044)2.86783945
35DNA catabolic process, exonucleolytic (GO:0000738)2.81109073
36myeloid cell activation involved in immune response (GO:0002275)2.79664615
37immunoglobulin mediated immune response (GO:0016064)2.79129784
38negative regulation of B cell proliferation (GO:0030889)2.78930287
39antigen processing and presentation of endogenous antigen (GO:0019883)2.78499302
40regulation of gamma-delta T cell differentiation (GO:0045586)2.76561529
41definitive hemopoiesis (GO:0060216)2.74005955
42negative regulation of DNA-dependent DNA replication (GO:2000104)2.72770766
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72336064
44negative regulation of cell killing (GO:0031342)2.72336064
45ncRNA catabolic process (GO:0034661)2.70208368
46regulation of pigment cell differentiation (GO:0050932)2.69721426
47negative regulation of execution phase of apoptosis (GO:1900118)2.69415180
48leukocyte degranulation (GO:0043299)2.67741401
49glycosphingolipid biosynthetic process (GO:0006688)2.65460791
50regulation of alpha-beta T cell proliferation (GO:0046640)2.64996580
51negative thymic T cell selection (GO:0045060)2.62490930
52double-strand break repair via homologous recombination (GO:0000724)2.59747023
53recombinational repair (GO:0000725)2.59606981
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59346542
55megakaryocyte development (GO:0035855)2.57387238
56regulation of nuclear cell cycle DNA replication (GO:0033262)2.53917544
57negative T cell selection (GO:0043383)2.52528081
58neutrophil mediated immunity (GO:0002446)2.51926589
59regulation of B cell apoptotic process (GO:0002902)2.51769850
60regulation of MHC class II biosynthetic process (GO:0045346)2.51581752
61negative regulation of T cell mediated immunity (GO:0002710)2.51300035
62B cell mediated immunity (GO:0019724)2.50953708
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50404179
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49790467
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49790467
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.49790467
67macrophage activation involved in immune response (GO:0002281)2.49342978
68regulation of interferon-alpha production (GO:0032647)2.49159413
69microglial cell activation (GO:0001774)2.48910291
70positive regulation of interferon-alpha production (GO:0032727)2.47604452
71positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47477719
72negative regulation of phagocytosis (GO:0050765)2.46728326
73regulation of MHC class I biosynthetic process (GO:0045343)2.46296494
74negative regulation of lymphocyte mediated immunity (GO:0002707)2.44208601
75lymphoid progenitor cell differentiation (GO:0002320)2.44010875
76sister chromatid cohesion (GO:0007062)2.43137709
77regulation of interferon-beta production (GO:0032648)2.43086702
78detection of molecule of bacterial origin (GO:0032490)2.42847141
79dendritic cell migration (GO:0036336)2.42437057
80histone H4-K16 acetylation (GO:0043984)2.41344450
81positive regulation of histone methylation (GO:0031062)2.40977739
82positive regulation of interferon-beta production (GO:0032728)2.39449554
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.38826381
84histone H3-K9 modification (GO:0061647)2.38039007
85regulation of protein glycosylation (GO:0060049)2.37435480
86Golgi to endosome transport (GO:0006895)2.36915641
87detection of other organism (GO:0098543)2.34285039
88positive T cell selection (GO:0043368)2.33749994
89DNA topological change (GO:0006265)2.33744498
90detection of bacterium (GO:0016045)2.33339130
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32793842
92granulocyte activation (GO:0036230)2.32366299
93protein ADP-ribosylation (GO:0006471)2.32032627
94regulation of granulocyte differentiation (GO:0030852)2.31604566
95positive regulation of developmental pigmentation (GO:0048087)2.31209880
96histone H3-K9 methylation (GO:0051567)2.30574734
97histone H4-K8 acetylation (GO:0043982)2.30365608
98histone H4-K5 acetylation (GO:0043981)2.30365608
99negative regulation of immunoglobulin mediated immune response (GO:0002890)2.28745374
100negative regulation of B cell mediated immunity (GO:0002713)2.28745374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.82124525
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23309511
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.68386663
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50319591
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.49482824
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40711353
7* ZNF274_21170338_ChIP-Seq_K562_Hela2.33836197
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32136915
9ELK1_19687146_ChIP-ChIP_HELA_Human2.31514166
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20962547
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.13765382
12VDR_23849224_ChIP-Seq_CD4+_Human1.91625705
13E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88763346
14MYB_26560356_Chip-Seq_TH2_Human1.88498067
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.86884152
16FUS_26573619_Chip-Seq_HEK293_Human1.85478102
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.84514278
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79212173
19* SPI1_23547873_ChIP-Seq_NB4_Human1.78480044
20EWS_26573619_Chip-Seq_HEK293_Human1.76560158
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71038767
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70396280
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69558216
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62022528
25GATA3_26560356_Chip-Seq_TH2_Human1.59667946
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58578390
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.56727495
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56337924
29IGF1R_20145208_ChIP-Seq_DFB_Human1.55039951
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54638384
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50160238
32* MYB_26560356_Chip-Seq_TH1_Human1.48412350
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47647480
34IRF1_19129219_ChIP-ChIP_H3396_Human1.47352091
35ER_23166858_ChIP-Seq_MCF-7_Human1.46689611
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.45471134
37E2F7_22180533_ChIP-Seq_HELA_Human1.45070922
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.44623291
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44384588
40GATA1_22025678_ChIP-Seq_K562_Human1.43420476
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43231501
42CIITA_25753668_ChIP-Seq_RAJI_Human1.41358539
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40797902
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40322858
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39017700
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.36304673
47TAF15_26573619_Chip-Seq_HEK293_Human1.36303348
48GATA3_27048872_Chip-Seq_THYMUS_Human1.34108922
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33231406
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.31785570
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30672768
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.30205075
53SCL_19346495_ChIP-Seq_HPC-7_Human1.30189347
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28260074
55P300_19829295_ChIP-Seq_ESCs_Human1.24858634
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23280253
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22952456
58RUNX_20019798_ChIP-Seq_JUKART_Human1.22506412
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21653868
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21389581
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19192616
62CBP_20019798_ChIP-Seq_JUKART_Human1.19192616
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15685069
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15272525
65VDR_24787735_ChIP-Seq_THP-1_Human1.14939644
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14713241
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13749248
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.12306599
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12269937
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12229835
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10864129
72GATA3_26560356_Chip-Seq_TH1_Human1.08077683
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05038869
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04744928
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04485372
76STAT3_23295773_ChIP-Seq_U87_Human1.03452797
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03377941
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02942326
79TP53_22573176_ChIP-Seq_HFKS_Human1.02430272
80CDX2_22108803_ChIP-Seq_LS180_Human1.00306666
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.00099604
82MYC_18940864_ChIP-ChIP_HL60_Human1.00029023
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99720159
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99515217
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99404760
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.98899146
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98490045
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97988602
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97644558
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97535162
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97517025
92SMRT_27268052_Chip-Seq_Bcells_Human0.94846124
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93271133
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93202621
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92321134
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92174560
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89429232
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.89237125
99P53_22387025_ChIP-Seq_ESCs_Mouse0.88676960
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88576377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.37353634
2MP0002396_abnormal_hematopoietic_system3.88515206
3MP0001835_abnormal_antigen_presentation3.67531421
4MP0008877_abnormal_DNA_methylation2.93078649
5MP0008058_abnormal_DNA_repair2.92738758
6MP0003787_abnormal_imprinting2.50250887
7MP0005367_renal/urinary_system_phenotyp2.17814201
8MP0000516_abnormal_urinary_system2.17814201
9MP0003724_increased_susceptibility_to2.07223044
10MP0001800_abnormal_humoral_immune2.02415688
11MP0005075_abnormal_melanosome_morpholog2.01441878
12MP0005397_hematopoietic_system_phenotyp1.98627234
13MP0001545_abnormal_hematopoietic_system1.98627234
14MP0006292_abnormal_olfactory_placode1.98211945
15MP0003950_abnormal_plasma_membrane1.91885591
16MP0000569_abnormal_digit_pigmentation1.79075711
17MP0003252_abnormal_bile_duct1.75555617
18MP0002723_abnormal_immune_serum1.65077441
19MP0008007_abnormal_cellular_replicative1.64770600
20MP0004883_abnormal_blood_vessel1.60880927
21MP0002420_abnormal_adaptive_immunity1.60735053
22MP0000685_abnormal_immune_system1.58271200
23MP0001819_abnormal_immune_cell1.58142933
24MP0002452_abnormal_antigen_presenting1.57930501
25MP0002419_abnormal_innate_immunity1.55765879
26MP0002398_abnormal_bone_marrow1.54428819
27MP0009785_altered_susceptibility_to1.54396904
28MP0002837_dystrophic_cardiac_calcinosis1.52753888
29MP0005387_immune_system_phenotype1.52392136
30MP0001790_abnormal_immune_system1.52392136
31MP0005174_abnormal_tail_pigmentation1.50996208
32MP0000689_abnormal_spleen_morphology1.49718092
33MP0005671_abnormal_response_to1.49617231
34MP0000015_abnormal_ear_pigmentation1.47421223
35MP0005379_endocrine/exocrine_gland_phen1.46297272
36MP0002166_altered_tumor_susceptibility1.45695967
37MP0004808_abnormal_hematopoietic_stem1.45532977
38MP0002009_preneoplasia1.45076847
39MP0003763_abnormal_thymus_physiology1.43091615
40MP0000427_abnormal_hair_cycle1.36114353
41MP0003806_abnormal_nucleotide_metabolis1.36070276
42MP0000716_abnormal_immune_system1.35946094
43MP0001188_hyperpigmentation1.35522818
44MP0010094_abnormal_chromosome_stability1.34489117
45MP0003303_peritoneal_inflammation1.31058140
46MP0005025_abnormal_response_to1.29855446
47MP0002722_abnormal_immune_system1.28471177
48MP0000703_abnormal_thymus_morphology1.27183270
49MP0002405_respiratory_system_inflammati1.25339776
50MP0003195_calcinosis1.24423774
51MP0005266_abnormal_metabolism1.23964663
52MP0005000_abnormal_immune_tolerance1.23763323
53MP0002102_abnormal_ear_morphology1.20258388
54MP0010155_abnormal_intestine_physiology1.16338214
55MP0002429_abnormal_blood_cell1.16138281
56MP0009764_decreased_sensitivity_to1.13854995
57MP0003172_abnormal_lysosome_physiology1.12384828
58MP0005645_abnormal_hypothalamus_physiol1.12112289
59MP0006054_spinal_hemorrhage1.11132436
60MP0006082_CNS_inflammation1.10306893
61MP0009697_abnormal_copulation1.09309373
62MP0001853_heart_inflammation1.08572450
63MP0002138_abnormal_hepatobiliary_system1.07682554
64MP0009278_abnormal_bone_marrow1.02512231
65MP0005464_abnormal_platelet_physiology1.01959488
66MP0004147_increased_porphyrin_level1.00979537
67MP0003121_genomic_imprinting0.98897035
68MP0003183_abnormal_peptide_metabolism0.98719861
69MP0003656_abnormal_erythrocyte_physiolo0.98270650
70MP0003786_premature_aging0.97878846
71MP0008995_early_reproductive_senescence0.96831710
72MP0005376_homeostasis/metabolism_phenot0.93601823
73MP0004381_abnormal_hair_follicle0.93484096
74MP0003436_decreased_susceptibility_to0.92888055
75MP0006072_abnormal_retinal_apoptosis0.92236854
76MP0003191_abnormal_cellular_cholesterol0.91925889
77MP0002006_tumorigenesis0.90685061
78MP0004043_abnormal_pH_regulation0.89171205
79MP0008469_abnormal_protein_level0.88502626
80MP0001845_abnormal_inflammatory_respons0.87903001
81MP0005220_abnormal_exocrine_pancreas0.87734070
82MP0000372_irregular_coat_pigmentation0.85376168
83MP0005365_abnormal_bile_salt0.84954659
84MP0002127_abnormal_cardiovascular_syste0.84089640
85MP0006036_abnormal_mitochondrial_physio0.83092293
86MP0002148_abnormal_hypersensitivity_rea0.82613374
87MP0002095_abnormal_skin_pigmentation0.81521498
88MP0005310_abnormal_salivary_gland0.80791986
89MP0003866_abnormal_defecation0.78877423
90MP0005551_abnormal_eye_electrophysiolog0.78187724
91MP0002019_abnormal_tumor_incidence0.78119906
92MP0002132_abnormal_respiratory_system0.77865408
93MP0005410_abnormal_fertilization0.75184862
94MP0008775_abnormal_heart_ventricle0.74479390
95MP0005164_abnormal_response_to0.73740682
96MP0002928_abnormal_bile_duct0.73274838
97MP0009115_abnormal_fat_cell0.72382691
98MP0004264_abnormal_extraembryonic_tissu0.70777507
99MP0003221_abnormal_cardiomyocyte_apopto0.69391159
100MP0001929_abnormal_gametogenesis0.69075326

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)3.71469554
2Acute lymphatic leukemia (HP:0006721)3.38222861
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.34581733
4Clubbing of toes (HP:0100760)3.06123460
5Acute myeloid leukemia (HP:0004808)3.03902893
6Stomatitis (HP:0010280)3.03385624
7Chronic diarrhea (HP:0002028)2.97084035
8Abnormality of chromosome stability (HP:0003220)2.96198062
9Recurrent fungal infections (HP:0002841)2.95870937
10Recurrent cutaneous fungal infections (HP:0011370)2.93529630
11Chronic mucocutaneous candidiasis (HP:0002728)2.93529630
12Metaphyseal dysplasia (HP:0100255)2.67961608
13Thyroiditis (HP:0100646)2.61537742
14Abnormality of T cell physiology (HP:0011840)2.54928488
15Hematochezia (HP:0002573)2.52265914
16Recurrent gram-negative bacterial infections (HP:0005420)2.51576688
17Recurrent viral infections (HP:0004429)2.50464692
18Agammaglobulinemia (HP:0004432)2.49915444
19Optic neuritis (HP:0100653)2.49626762
20Retrobulbar optic neuritis (HP:0100654)2.49626762
21Abnormality of the preputium (HP:0100587)2.46012054
22Pancreatic cysts (HP:0001737)2.45757150
23Encephalitis (HP:0002383)2.43883284
24Viral hepatitis (HP:0006562)2.43394430
25Attenuation of retinal blood vessels (HP:0007843)2.42443147
26Abnormal rod and cone electroretinograms (HP:0008323)2.40347494
27Recurrent bacterial skin infections (HP:0005406)2.37647577
28Constricted visual fields (HP:0001133)2.36999693
29Neoplasm of the tracheobronchial system (HP:0100552)2.35947873
30Recurrent abscess formation (HP:0002722)2.33976492
31Meningitis (HP:0001287)2.33868418
32Alveolar cell carcinoma (HP:0006519)2.33138318
33Myositis (HP:0100614)2.32870615
34Medial flaring of the eyebrow (HP:0010747)2.31937771
35Nephronophthisis (HP:0000090)2.29857613
36Inflammation of the large intestine (HP:0002037)2.29803110
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.29532720
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25851450
39Widely spaced teeth (HP:0000687)2.23834301
40Biliary tract neoplasm (HP:0100574)2.21846935
41Recurrent skin infections (HP:0001581)2.19253973
42Myelodysplasia (HP:0002863)2.18663341
43Volvulus (HP:0002580)2.12605730
44Abnormality of T cells (HP:0002843)2.10910127
45Cutaneous melanoma (HP:0012056)2.10565227
46Orchitis (HP:0100796)2.07399535
47True hermaphroditism (HP:0010459)2.07291605
48Keratoconjunctivitis (HP:0001096)2.07207168
49Abnormality of the prostate (HP:0008775)2.07094602
50Gastrointestinal inflammation (HP:0004386)2.05696774
51Stomach cancer (HP:0012126)2.05053006
52Abnormality of B cell number (HP:0010975)2.04052650
53Colitis (HP:0002583)2.03480544
54Neonatal respiratory distress (HP:0002643)2.02867564
55Abnormality of the renal medulla (HP:0100957)2.00058755
56Acute hepatic failure (HP:0006554)1.99769283
57Pancreatic fibrosis (HP:0100732)1.99132210
58Keratoconjunctivitis sicca (HP:0001097)1.97579617
59Choroideremia (HP:0001139)1.96653936
60Pustule (HP:0200039)1.95052598
61Vasculitis (HP:0002633)1.94998078
62Hypochromic microcytic anemia (HP:0004840)1.93836570
63Meckel diverticulum (HP:0002245)1.93787683
64Pulmonary embolism (HP:0002204)1.93735358
65Abnormal biliary tract morphology (HP:0012440)1.93195994
66Gaze-evoked nystagmus (HP:0000640)1.92106452
67Abnormality of the ileum (HP:0001549)1.91923614
68Sloping forehead (HP:0000340)1.86677040
69Neoplasm of the adrenal cortex (HP:0100641)1.86281491
70Hypoplastic iliac wings (HP:0002866)1.83514179
71Chromsome breakage (HP:0040012)1.83429567
72Azoospermia (HP:0000027)1.81522964
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81389802
74Chest pain (HP:0100749)1.81382504
75Duplicated collecting system (HP:0000081)1.81326725
76Prolonged bleeding time (HP:0003010)1.80623318
77B lymphocytopenia (HP:0010976)1.77281257
78Tubular atrophy (HP:0000092)1.77235909
79Hemoptysis (HP:0002105)1.74739655
80Congenital stationary night blindness (HP:0007642)1.72396847
81Abnormality of male internal genitalia (HP:0000022)1.71669432
82Hypoproteinemia (HP:0003075)1.71417823
83Chronic obstructive pulmonary disease (HP:0006510)1.69012735
84Obstructive lung disease (HP:0006536)1.69012735
85Rhabdomyosarcoma (HP:0002859)1.68715929
86Basal cell carcinoma (HP:0002671)1.68679136
87Keratitis (HP:0000491)1.68069739
88Arterial thrombosis (HP:0004420)1.67997272
89IgM deficiency (HP:0002850)1.67945387
90Abnormality of the renal collecting system (HP:0004742)1.67265538
91Cutis marmorata (HP:0000965)1.65447550
92Neutropenia (HP:0001875)1.64034625
93Decreased central vision (HP:0007663)1.62696174
94Poikilocytosis (HP:0004447)1.62333387
95Abnormality of the renal cortex (HP:0011035)1.61755603
96Progressive external ophthalmoplegia (HP:0000590)1.61181328
97Limb hypertonia (HP:0002509)1.60765100
98Abnormality of T cell number (HP:0011839)1.59587690
99T lymphocytopenia (HP:0005403)1.58803279
100Mediastinal lymphadenopathy (HP:0100721)1.58746851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26048977
2MAP4K22.83290789
3MST42.72030154
4FLT32.59650032
5TAOK32.57162555
6KIT2.38876543
7RIPK42.23640577
8EIF2AK32.20497798
9MAP4K12.18448897
10TEC2.01966780
11NUAK12.01497334
12CSF1R1.98610978
13BMPR21.91619778
14STK31.90090769
15BRD41.89044558
16MKNK21.88641286
17TYK21.86590347
18ACVR1B1.78220441
19MAP3K21.72704541
20PINK11.66482302
21MKNK11.65206132
22TRIM281.62107973
23PIK3CG1.37449749
24BTK1.31317881
25ADRBK21.30407393
26CDK191.30079469
27OXSR11.24554810
28FGFR21.24455032
29MAP3K41.24231409
30ITK1.23734227
31BMPR1B1.19127451
32TXK1.18875917
33LYN1.14289144
34WNK31.11809537
35RPS6KA41.10826311
36SYK1.09146220
37ERBB31.05931862
38MARK31.05358881
39ZAK1.04678417
40CDK31.02933964
41PLK40.95839997
42STK100.95474597
43TNK20.94998776
44GRK70.92473838
45HCK0.92469962
46STK40.91744228
47PTK2B0.90279988
48FGFR30.88409589
49BLK0.87723113
50MAP2K30.87527195
51AKT30.87415231
52IKBKB0.86551750
53TAF10.85404097
54PIK3CA0.80336240
55LCK0.79488468
56SIK30.77641721
57MAP3K140.73340686
58IKBKE0.72154349
59IRAK40.70452123
60JAK30.68090103
61PRKCQ0.67253155
62EIF2AK20.66846621
63NEK20.66461104
64GRK60.65911638
65NLK0.64098130
66JAK10.63746163
67SGK20.63401495
68GRK10.62084337
69STK390.61597943
70MATK0.61260481
71SCYL20.60065499
72PRKCE0.59594795
73DYRK30.58852950
74PASK0.58512379
75JAK20.57212989
76RAF10.56149973
77KSR10.55851815
78CSK0.53275647
79BRSK20.53120786
80SGK30.50502320
81CDK60.50273540
82MAPK130.50270109
83ATR0.48582706
84PAK30.46387024
85FGR0.45281110
86YES10.44398216
87MAP3K60.44034728
88NEK90.41237305
89PLK30.40288012
90CDC70.39708994
91TRPM70.39553497
92SIK20.39295414
93EGFR0.38376872
94STK110.37392171
95NTRK30.36889597
96ATM0.35961885
97FES0.34770700
98SGK10.34515030
99ABL10.33711369
100KSR20.33048228

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.38232088
2Allograft rejection_Homo sapiens_hsa053302.97806415
3Graft-versus-host disease_Homo sapiens_hsa053322.89293929
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.83105377
5Autoimmune thyroid disease_Homo sapiens_hsa053202.79378221
6Type I diabetes mellitus_Homo sapiens_hsa049402.68135970
7Non-homologous end-joining_Homo sapiens_hsa034502.65466986
8Fanconi anemia pathway_Homo sapiens_hsa034602.54196009
9Staphylococcus aureus infection_Homo sapiens_hsa051502.39958920
10Leishmaniasis_Homo sapiens_hsa051402.14709852
11Homologous recombination_Homo sapiens_hsa034402.04978070
12Primary immunodeficiency_Homo sapiens_hsa053401.95775353
13Antigen processing and presentation_Homo sapiens_hsa046121.90982168
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72796291
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62623258
16Basal transcription factors_Homo sapiens_hsa030221.62108158
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58962472
18Mismatch repair_Homo sapiens_hsa034301.54561487
19Herpes simplex infection_Homo sapiens_hsa051681.52794974
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50431156
21Osteoclast differentiation_Homo sapiens_hsa043801.49053237
22Hematopoietic cell lineage_Homo sapiens_hsa046401.45472676
23Tuberculosis_Homo sapiens_hsa051521.39700421
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31899562
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31140265
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28855279
27Ether lipid metabolism_Homo sapiens_hsa005651.27701674
28Viral myocarditis_Homo sapiens_hsa054161.25683317
29B cell receptor signaling pathway_Homo sapiens_hsa046621.22854938
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22250175
31Regulation of autophagy_Homo sapiens_hsa041401.20975203
32Protein export_Homo sapiens_hsa030601.19998066
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.18284535
34RNA degradation_Homo sapiens_hsa030181.15591194
35DNA replication_Homo sapiens_hsa030301.09338688
36Toxoplasmosis_Homo sapiens_hsa051451.08565692
37Selenocompound metabolism_Homo sapiens_hsa004501.08233959
38Butanoate metabolism_Homo sapiens_hsa006501.08052244
39Nitrogen metabolism_Homo sapiens_hsa009101.06039611
40Base excision repair_Homo sapiens_hsa034101.04499869
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04104715
42p53 signaling pathway_Homo sapiens_hsa041151.01337589
43Rheumatoid arthritis_Homo sapiens_hsa053230.99543246
44Influenza A_Homo sapiens_hsa051640.99344849
45Measles_Homo sapiens_hsa051620.97950161
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97009076
47Linoleic acid metabolism_Homo sapiens_hsa005910.96521714
48One carbon pool by folate_Homo sapiens_hsa006700.94961207
49Legionellosis_Homo sapiens_hsa051340.92818731
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88698090
51Phototransduction_Homo sapiens_hsa047440.86123752
52T cell receptor signaling pathway_Homo sapiens_hsa046600.86115381
53Nucleotide excision repair_Homo sapiens_hsa034200.83406222
54Platelet activation_Homo sapiens_hsa046110.83302052
55Dorso-ventral axis formation_Homo sapiens_hsa043200.80718849
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80592361
57Inositol phosphate metabolism_Homo sapiens_hsa005620.77822384
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77230285
59RNA transport_Homo sapiens_hsa030130.75086821
60Acute myeloid leukemia_Homo sapiens_hsa052210.72871690
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.71758195
62Vitamin B6 metabolism_Homo sapiens_hsa007500.71156517
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70175267
64Sphingolipid metabolism_Homo sapiens_hsa006000.66861819
65Systemic lupus erythematosus_Homo sapiens_hsa053220.65980702
66Propanoate metabolism_Homo sapiens_hsa006400.65782607
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64865455
68mTOR signaling pathway_Homo sapiens_hsa041500.54954845
69Chemokine signaling pathway_Homo sapiens_hsa040620.54926630
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.54777305
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54459631
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54125897
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53567913
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52823326
75Epstein-Barr virus infection_Homo sapiens_hsa051690.52634219
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52244050
77Hepatitis B_Homo sapiens_hsa051610.50698867
78Viral carcinogenesis_Homo sapiens_hsa052030.50674062
79Caffeine metabolism_Homo sapiens_hsa002320.49390340
80Peroxisome_Homo sapiens_hsa041460.49290417
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48620973
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46224693
83TNF signaling pathway_Homo sapiens_hsa046680.46039071
84mRNA surveillance pathway_Homo sapiens_hsa030150.46030697
85Tryptophan metabolism_Homo sapiens_hsa003800.44958942
86Prolactin signaling pathway_Homo sapiens_hsa049170.44764929
87Arachidonic acid metabolism_Homo sapiens_hsa005900.44150265
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.43865178
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43614633
90Collecting duct acid secretion_Homo sapiens_hsa049660.42230202
91Spliceosome_Homo sapiens_hsa030400.40909756
92Other glycan degradation_Homo sapiens_hsa005110.37872865
93Olfactory transduction_Homo sapiens_hsa047400.37380770
94African trypanosomiasis_Homo sapiens_hsa051430.37161203
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36995035
96Hepatitis C_Homo sapiens_hsa051600.36634104
97Phagosome_Homo sapiens_hsa041450.36415740
98Retinol metabolism_Homo sapiens_hsa008300.33382896
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32714705
100ABC transporters_Homo sapiens_hsa020100.28996628

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