ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	3.97160656
2	DNA double-strand break processing (GO:0000729)	3.72395189
3	protein K11-linked deubiquitination (GO:0035871)	3.68033161
4	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.66512510
5	regulation of mitotic spindle checkpoint (GO:1903504)	3.66512510
6	synapsis (GO:0007129)	3.47887272
7	rRNA methylation (GO:0031167)	3.46085306
8	centriole replication (GO:0007099)	3.41714021
9	proteasome assembly (GO:0043248)	3.33954597
10	neural tube formation (GO:0001841)	3.32189930
11	histone mRNA catabolic process (GO:0071044)	3.19844153
12	rRNA modification (GO:0000154)	3.07451970
13	double-strand break repair via homologous recombination (GO:0000724)	3.06849849
14	preassembly of GPI anchor in ER membrane (GO:0016254)	3.05406922
15	positive regulation of granulocyte differentiation (GO:0030854)	3.02387120
16	recombinational repair (GO:0000725)	3.02285414
17	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.00543319
18	regulation of meiosis I (GO:0060631)	2.99728428
19	cytidine deamination (GO:0009972)	2.95981219
20	cytidine metabolic process (GO:0046087)	2.95981219
21	cytidine catabolic process (GO:0006216)	2.95981219
22	regulation of centriole replication (GO:0046599)	2.92491199
23	regulation of B cell receptor signaling pathway (GO:0050855)	2.88047126
24	protein prenylation (GO:0018342)	2.87929505
25	prenylation (GO:0097354)	2.87929505
26	monoubiquitinated protein deubiquitination (GO:0035520)	2.87563053
27	regulation of DNA endoreduplication (GO:0032875)	2.85851686
28	DNA catabolic process, exonucleolytic (GO:0000738)	2.82814693
29	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.82017891
30	isotype switching (GO:0045190)	2.82017891
31	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.82017891
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.80608517
33	DNA demethylation (GO:0080111)	2.79899944
34	protein K6-linked ubiquitination (GO:0085020)	2.78955436
35	regulation of helicase activity (GO:0051095)	2.76576459
36	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74841560
37	L-fucose catabolic process (GO:0042355)	2.67993493
38	fucose catabolic process (GO:0019317)	2.67993493
39	L-fucose metabolic process (GO:0042354)	2.67993493
40	replication fork processing (GO:0031297)	2.65922344
41	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.64577852
42	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.61766401
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.61440843
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.61440843
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.60052858
46	cell wall macromolecule catabolic process (GO:0016998)	2.58810166
47	establishment of protein localization to Golgi (GO:0072600)	2.57793690
48	C-terminal protein lipidation (GO:0006501)	2.56745700
49	negative regulation of execution phase of apoptosis (GO:1900118)	2.52650955
50	platelet dense granule organization (GO:0060155)	2.50693135
51	attachment of spindle microtubules to kinetochore (GO:0008608)	2.50413639
52	positive regulation of gamma-delta T cell activation (GO:0046645)	2.50148197
53	histone mRNA metabolic process (GO:0008334)	2.46611727
54	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.46100212
55	adenosine metabolic process (GO:0046085)	2.44517440
56	DNA replication checkpoint (GO:0000076)	2.44086990
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42476614
58	mitotic sister chromatid cohesion (GO:0007064)	2.42157057
59	negative regulation of DNA recombination (GO:0045910)	2.41453443
60	double-strand break repair (GO:0006302)	2.39899266
61	S-adenosylmethionine metabolic process (GO:0046500)	2.38443034
62	C-terminal protein amino acid modification (GO:0018410)	2.38391531
63	neutrophil activation involved in immune response (GO:0002283)	2.38305358
64	mitotic G2/M transition checkpoint (GO:0044818)	2.38079325
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.36784974
66	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.36185517
67	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.36185517
68	regulation of translation, ncRNA-mediated (GO:0045974)	2.36185517
69	protein targeting to Golgi (GO:0000042)	2.34034082
70	piRNA metabolic process (GO:0034587)	2.33637544
71	tryptophan catabolic process (GO:0006569)	2.33107928
72	indole-containing compound catabolic process (GO:0042436)	2.33107928
73	indolalkylamine catabolic process (GO:0046218)	2.33107928
74	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.33069961
75	organelle disassembly (GO:1903008)	2.32755495
76	peptidyl-histidine modification (GO:0018202)	2.32563399
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.32369401
78	DNA dealkylation (GO:0035510)	2.31822231
79	male meiosis I (GO:0007141)	2.31272243
80	histamine secretion (GO:0001821)	2.31195447
81	mannosylation (GO:0097502)	2.30904184
82	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.29673080
83	indolalkylamine metabolic process (GO:0006586)	2.29437041
84	cellular response to interleukin-15 (GO:0071350)	2.29265095
85	neutrophil activation (GO:0042119)	2.29093812
86	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.28105809
87	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.28105809
88	DNA methylation involved in gamete generation (GO:0043046)	2.27844049
89	positive regulation of mRNA catabolic process (GO:0061014)	2.27401619
90	leukocyte degranulation (GO:0043299)	2.27084060
91	male meiosis (GO:0007140)	2.27081090
92	peptidyl-lysine trimethylation (GO:0018023)	2.24179621
93	hepatocyte apoptotic process (GO:0097284)	2.23364446
94	pyrimidine dimer repair (GO:0006290)	2.22970236
95	microtubule anchoring (GO:0034453)	2.22910783
96	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.22750796
97	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.22750796
98	keratinocyte development (GO:0003334)	2.22720001
99	organelle membrane fusion (GO:0090174)	2.22596528
100	photoreceptor cell maintenance (GO:0045494)	2.22207082

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.06306322
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.05656216
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01290668
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.99016303
5	* ELK1_19687146_ChIP-ChIP_HELA_Human	2.65923208
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55468997
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.45505917
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43205457
9	VDR_22108803_ChIP-Seq_LS180_Human	2.42191916
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.40763472
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.34199404
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.30679911
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29087762
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22992684
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19794764
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.16191569
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.03315708
18	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.95997964
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92961416
20	EWS_26573619_Chip-Seq_HEK293_Human	1.86726840
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.84274627
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.84171054
23	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.82922983
24	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.77162257
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.75796407
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71543394
27	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.69290197
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.69102476
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.65897142
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64927310
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.60358299
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.58526475
33	FUS_26573619_Chip-Seq_HEK293_Human	1.53448540
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48622799
35	P300_19829295_ChIP-Seq_ESCs_Human	1.46197902
36	GATA3_26560356_Chip-Seq_TH2_Human	1.44250504
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41965868
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.41791925
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38045905
40	MYB_26560356_Chip-Seq_TH2_Human	1.36492645
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36258018
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36165514
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32007171
44	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25702913
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25486857
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.24103813
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23983587
48	E2F7_22180533_ChIP-Seq_HELA_Human	1.23874402
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.23237008
50	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.23194590
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22736712
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22416732
53	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.22161138
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21506785
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.20515876
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19857424
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.19266161
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17930188
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17062790
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.16033706
61	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14590349
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13812139
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10561937
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10294558
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10078795
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10078795
67	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.09755192
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.08306622
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07755087
70	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.07320679
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05782731
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05782731
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.05734342
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.05690816
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04576141
76	MYB_26560356_Chip-Seq_TH1_Human	1.03825731
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.03285525
78	DCP1A_22483619_ChIP-Seq_HELA_Human	1.01451685
79	GATA3_27048872_Chip-Seq_THYMUS_Human	1.00899333
80	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.99984718
81	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.99850850
82	BCAT_22108803_ChIP-Seq_LS180_Human	0.99358670
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99083243
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.99083243
85	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98053600
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96468464
87	P300_18555785_Chip-Seq_ESCs_Mouse	0.95674460
88	GATA3_26560356_Chip-Seq_TH1_Human	0.94846181
89	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94616263
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94255002
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93810575
92	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93285283
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93247424
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92918429
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92215558
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91855820
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91562512
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.91536050
99	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.91300480
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90783185

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.37936717
2	MP0008877_abnormal_DNA_methylation	2.92732874
3	MP0008058_abnormal_DNA_repair	2.91804509
4	MP0003195_calcinosis	2.50598496
5	MP0000372_irregular_coat_pigmentation	2.50227550
6	MP0006054_spinal_hemorrhage	2.38372511
7	MP0005075_abnormal_melanosome_morpholog	2.31391798
8	MP0010094_abnormal_chromosome_stability	2.17846245
9	MP0001835_abnormal_antigen_presentation	1.88417192
10	MP0008995_early_reproductive_senescence	1.86663418
11	MP0003786_premature_aging	1.81817660
12	MP0000015_abnormal_ear_pigmentation	1.77757274
13	MP0003724_increased_susceptibility_to	1.71429031
14	MP0001800_abnormal_humoral_immune	1.70959448
15	MP0005671_abnormal_response_to	1.70420495
16	MP0003693_abnormal_embryo_hatching	1.69063845
17	MP0003763_abnormal_thymus_physiology	1.67810038
18	MP0000569_abnormal_digit_pigmentation	1.67319428
19	MP0009785_altered_susceptibility_to	1.66046665
20	MP0000427_abnormal_hair_cycle	1.64192929
21	MP0005408_hypopigmentation	1.63112435
22	MP0009697_abnormal_copulation	1.62083991
23	MP0004957_abnormal_blastocyst_morpholog	1.59922390
24	MP0002102_abnormal_ear_morphology	1.59666688
25	MP0004147_increased_porphyrin_level	1.56657754
26	MP0002132_abnormal_respiratory_system	1.56522655
27	MP0003718_maternal_effect	1.50629033
28	MP0002452_abnormal_antigen_presenting	1.44921238
29	MP0002148_abnormal_hypersensitivity_rea	1.43905650
30	MP0002723_abnormal_immune_serum	1.42115046
31	MP0005645_abnormal_hypothalamus_physiol	1.41984572
32	MP0002277_abnormal_respiratory_mucosa	1.39937807
33	MP0003787_abnormal_imprinting	1.39120510
34	MP0000689_abnormal_spleen_morphology	1.39101588
35	MP0002166_altered_tumor_susceptibility	1.38258600
36	MP0003950_abnormal_plasma_membrane	1.35245138
37	MP0002006_tumorigenesis	1.33906229
38	MP0002420_abnormal_adaptive_immunity	1.33089945
39	MP0001819_abnormal_immune_cell	1.31147593
40	MP0006035_abnormal_mitochondrial_morpho	1.31112522
41	MP0003890_abnormal_embryonic-extraembry	1.30715541
42	MP0002163_abnormal_gland_morphology	1.30526369
43	MP0006036_abnormal_mitochondrial_physio	1.29052417
44	MP0006072_abnormal_retinal_apoptosis	1.28378397
45	MP0002398_abnormal_bone_marrow	1.27824167
46	MP0008872_abnormal_physiological_respon	1.26470949
47	MP0005253_abnormal_eye_physiology	1.23497998
48	MP0005310_abnormal_salivary_gland	1.23364514
49	MP0005084_abnormal_gallbladder_morpholo	1.22566314
50	MP0005367_renal/urinary_system_phenotyp	1.22224331
51	MP0000516_abnormal_urinary_system	1.22224331
52	MP0002396_abnormal_hematopoietic_system	1.19766979
53	MP0002254_reproductive_system_inflammat	1.18063878
54	MP0005174_abnormal_tail_pigmentation	1.17439198
55	MP0003077_abnormal_cell_cycle	1.16777222
56	MP0005379_endocrine/exocrine_gland_phen	1.15796803
57	MP0002722_abnormal_immune_system	1.13399138
58	MP0003111_abnormal_nucleus_morphology	1.13273664
59	MP0005000_abnormal_immune_tolerance	1.12605761
60	MP0005551_abnormal_eye_electrophysiolog	1.12438090
61	MP0001929_abnormal_gametogenesis	1.10680083
62	MP0000716_abnormal_immune_system	1.10238952
63	MP0010307_abnormal_tumor_latency	1.09741455
64	MP0001986_abnormal_taste_sensitivity	1.09705139
65	MP0000703_abnormal_thymus_morphology	1.08827156
66	MP0002419_abnormal_innate_immunity	1.07430533
67	MP0001119_abnormal_female_reproductive	1.07313166
68	MP0003656_abnormal_erythrocyte_physiolo	1.06869757
69	MP0002095_abnormal_skin_pigmentation	1.04455478
70	MP0000371_diluted_coat_color	1.01558193
71	MP0005387_immune_system_phenotype	1.01517719
72	MP0001790_abnormal_immune_system	1.01517719
73	MP0003806_abnormal_nucleotide_metabolis	1.00791831
74	MP0002019_abnormal_tumor_incidence	1.00764540
75	MP0005025_abnormal_response_to	1.00402410
76	MP0010386_abnormal_urinary_bladder	0.98506705
77	MP0000685_abnormal_immune_system	0.96673995
78	MP0006082_CNS_inflammation	0.96344119
79	MP0002693_abnormal_pancreas_physiology	0.92969849
80	MP0002928_abnormal_bile_duct	0.92647910
81	MP0005389_reproductive_system_phenotype	0.92359100
82	MP0001764_abnormal_homeostasis	0.91552410
83	MP0002429_abnormal_blood_cell	0.91305730
84	MP0002210_abnormal_sex_determination	0.91253787
85	MP0001485_abnormal_pinna_reflex	0.90457552
86	MP0004484_altered_response_of	0.89253389
87	MP0004381_abnormal_hair_follicle	0.88708686
88	MP0009764_decreased_sensitivity_to	0.88052446
89	MP0001845_abnormal_inflammatory_respons	0.87755169
90	MP0002138_abnormal_hepatobiliary_system	0.87141657
91	MP0001919_abnormal_reproductive_system	0.86738780
92	MP0002405_respiratory_system_inflammati	0.86047853
93	MP0004264_abnormal_extraembryonic_tissu	0.83814287
94	MP0005410_abnormal_fertilization	0.83706051
95	MP0004133_heterotaxia	0.81548753
96	MP0000653_abnormal_sex_gland	0.81172200
97	MP0003221_abnormal_cardiomyocyte_apopto	0.78718017
98	MP0001145_abnormal_male_reproductive	0.78024090
99	MP0003567_abnormal_fetal_cardiomyocyte	0.77840566
100	MP0005397_hematopoietic_system_phenotyp	0.77581977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	3.08707439
2	Pancreatic cysts (HP:0001737)	3.05077836
3	Abnormality of T cell number (HP:0011839)	2.83956668
4	T lymphocytopenia (HP:0005403)	2.74656347
5	Abnormality of the renal cortex (HP:0011035)	2.68010603
6	Abnormality of chromosome stability (HP:0003220)	2.66843185
7	Hypothermia (HP:0002045)	2.63035837
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.57875094
9	Chromsome breakage (HP:0040012)	2.55920719
10	Methylmalonic acidemia (HP:0002912)	2.53091051
11	Thyroiditis (HP:0100646)	2.52052626
12	Eosinophilia (HP:0001880)	2.50283008
13	Severe combined immunodeficiency (HP:0004430)	2.47019810
14	Stomach cancer (HP:0012126)	2.44601875
15	IgG deficiency (HP:0004315)	2.39693068
16	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.35995541
17	Panhypogammaglobulinemia (HP:0003139)	2.35248682
18	Abnormality of midbrain morphology (HP:0002418)	2.33586727
19	Molar tooth sign on MRI (HP:0002419)	2.33586727
20	Abnormality of eosinophils (HP:0001879)	2.32763395
21	Abnormality of the renal medulla (HP:0100957)	2.28102219
22	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27828323
23	Abnormality of T cells (HP:0002843)	2.24071371
24	Nephronophthisis (HP:0000090)	2.22999236
25	Volvulus (HP:0002580)	2.14631678
26	Methylmalonic aciduria (HP:0012120)	2.13386295
27	Ependymoma (HP:0002888)	2.12946267
28	Abnormality of B cell number (HP:0010975)	2.12688539
29	Granulocytopenia (HP:0001913)	2.12230323
30	Attenuation of retinal blood vessels (HP:0007843)	2.11709313
31	Medial flaring of the eyebrow (HP:0010747)	2.09653902
32	Abnormality of the preputium (HP:0100587)	2.09611724
33	Pancreatic fibrosis (HP:0100732)	2.09522571
34	Colon cancer (HP:0003003)	2.08945735
35	Abnormal glycosylation (HP:0012345)	2.04689064
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04689064
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.04689064
38	Abnormal protein glycosylation (HP:0012346)	2.04689064
39	Abnormality of the ileum (HP:0001549)	2.04621834
40	Hematochezia (HP:0002573)	2.03002338
41	Renal cortical cysts (HP:0000803)	2.01147247
42	Abnormality of T cell physiology (HP:0011840)	2.00457802
43	Abnormality of vitamin B metabolism (HP:0004340)	2.00397397
44	Meckel diverticulum (HP:0002245)	2.00118976
45	Combined immunodeficiency (HP:0005387)	1.99562318
46	Aplastic anemia (HP:0001915)	1.98056408
47	Recurrent fungal infections (HP:0002841)	1.97053026
48	Prostate neoplasm (HP:0100787)	1.96571429
49	B lymphocytopenia (HP:0010976)	1.94119410
50	Abnormality of homocysteine metabolism (HP:0010919)	1.93839728
51	Homocystinuria (HP:0002156)	1.93839728
52	Abnormality of the prostate (HP:0008775)	1.92602958
53	Nephrogenic diabetes insipidus (HP:0009806)	1.92425516
54	Chronic diarrhea (HP:0002028)	1.91494967
55	Sloping forehead (HP:0000340)	1.91011773
56	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.90056978
57	Leukocytosis (HP:0001974)	1.89343885
58	Alveolar cell carcinoma (HP:0006519)	1.86441785
59	Neutropenia (HP:0001875)	1.86404464
60	Hypoplasia of the fovea (HP:0007750)	1.86228500
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.86228500
62	Increased CSF lactate (HP:0002490)	1.86157732
63	Chronic hepatic failure (HP:0100626)	1.85452640
64	True hermaphroditism (HP:0010459)	1.82502489
65	Myelodysplasia (HP:0002863)	1.81715912
66	Clubbing of toes (HP:0100760)	1.81624361
67	Progressive macrocephaly (HP:0004481)	1.81381227
68	3-Methylglutaconic aciduria (HP:0003535)	1.81238063
69	Breast carcinoma (HP:0003002)	1.77242222
70	Gaze-evoked nystagmus (HP:0000640)	1.77183089
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.76210857
72	Type I transferrin isoform profile (HP:0003642)	1.76048077
73	Abnormality of the pancreatic islet cells (HP:0006476)	1.76015864
74	Abnormality of endocrine pancreas physiology (HP:0012093)	1.76015864
75	Tubular atrophy (HP:0000092)	1.75703930
76	Congenital stationary night blindness (HP:0007642)	1.73067216
77	Duodenal stenosis (HP:0100867)	1.72806564
78	Small intestinal stenosis (HP:0012848)	1.72806564
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.71911381
80	Autoimmune hemolytic anemia (HP:0001890)	1.71578220
81	Congenital primary aphakia (HP:0007707)	1.71508693
82	Hypoplastic iliac wings (HP:0002866)	1.71096695
83	Abnormality of methionine metabolism (HP:0010901)	1.70944300
84	Neoplasm of the tracheobronchial system (HP:0100552)	1.69470458
85	Retrobulbar optic neuritis (HP:0100654)	1.68814521
86	Optic neuritis (HP:0100653)	1.68814521
87	Cellular immunodeficiency (HP:0005374)	1.67550918
88	Albinism (HP:0001022)	1.66693954
89	IgM deficiency (HP:0002850)	1.66607102
90	Hyperglycinemia (HP:0002154)	1.66399280
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.66001663
92	Abolished electroretinogram (ERG) (HP:0000550)	1.65585691
93	Tubulointerstitial nephritis (HP:0001970)	1.65320702
94	Hepatocellular necrosis (HP:0001404)	1.64205271
95	Progressive inability to walk (HP:0002505)	1.63276036
96	Bile duct proliferation (HP:0001408)	1.63263555
97	Abnormal biliary tract physiology (HP:0012439)	1.63263555
98	Ectropion (HP:0000656)	1.61416994
99	Astigmatism (HP:0000483)	1.61166608
100	Recurrent cutaneous fungal infections (HP:0011370)	1.61065048

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.54570611
2	MST4	3.60510156
3	NUAK1	3.43152118
4	TRIM28	2.75138434
5	BRSK2	2.59785277
6	BMPR1B	2.57772597
7	TAOK3	2.46638653
8	EIF2AK3	2.30659874
9	ACVR1B	2.28160895
10	PLK4	2.03657701
11	ZAK	2.00605713
12	EPHA3	1.97378510
13	BCR	1.84746530
14	EIF2AK1	1.83966683
15	WEE1	1.83485340
16	TXK	1.72230482
17	WNK3	1.68366203
18	TNIK	1.66271089
19	MAP3K12	1.58382883
20	NLK	1.55715391
21	LATS1	1.46108115
22	STK3	1.41859515
23	MKNK2	1.40786758
24	ADRBK2	1.31115670
25	TEC	1.30821168
26	BMPR2	1.30544106
27	STK38L	1.26422893
28	MARK3	1.25764339
29	ERBB3	1.23023538
30	PDK2	1.21508316
31	GRK1	1.14804724
32	SRPK1	1.11695925
33	PAK3	1.06325483
34	PINK1	1.05043638
35	PLK3	0.99915033
36	SIK3	0.98427507
37	AKT3	0.98373585
38	MAPK13	0.96407143
39	MAP3K4	0.95937221
40	VRK1	0.95261002
41	PLK2	0.92205569
42	IKBKB	0.90983278
43	CCNB1	0.90218397
44	STK10	0.89260944
45	DYRK3	0.84511618
46	BUB1	0.81878837
47	IRAK4	0.81123332
48	MKNK1	0.80785575
49	FER	0.80276364
50	EIF2AK2	0.78371942
51	IKBKE	0.75415754
52	TAF1	0.74364017
53	BRD4	0.72073459
54	VRK2	0.71149260
55	PBK	0.70797306
56	BTK	0.69960026
57	IRAK1	0.69623995
58	OXSR1	0.69378889
59	PRKCQ	0.68842084
60	MELK	0.68418830
61	PIK3CG	0.66997791
62	CSNK1G1	0.66837611
63	RIPK4	0.62638681
64	TLK1	0.62004245
65	TTK	0.61072636
66	MAP4K1	0.60822393
67	JAK1	0.60612904
68	TYK2	0.59727791
69	CLK1	0.58793329
70	SYK	0.58545997
71	ITK	0.55568790
72	ATR	0.54849366
73	STK39	0.54613027
74	YES1	0.53418339
75	LYN	0.52071312
76	RPS6KA4	0.51989888
77	MAP4K2	0.50965135
78	MAP3K14	0.50810539
79	INSRR	0.50345478
80	PIM1	0.49720642
81	MATK	0.47687088
82	ATM	0.47648810
83	PLK1	0.45462322
84	MAP3K2	0.43955608
85	CSNK1G3	0.43944770
86	CDC7	0.43678673
87	TSSK6	0.43059676
88	JAK3	0.42139285
89	BCKDK	0.42088316
90	STK24	0.41853885
91	EGFR	0.41286827
92	GRK6	0.40450711
93	ABL1	0.38509776
94	LCK	0.38416136
95	HCK	0.38414416
96	CSNK1G2	0.38057543
97	BLK	0.36411003
98	JAK2	0.36364550
99	PRKCE	0.35309842
100	CASK	0.34885338

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.82011430
2	Basal transcription factors_Homo sapiens_hsa03022	2.78031415
3	Homologous recombination_Homo sapiens_hsa03440	2.72706411
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.71710356
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.70665543
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70303915
7	Proteasome_Homo sapiens_hsa03050	2.51532354
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.36300262
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.25731713
10	RNA polymerase_Homo sapiens_hsa03020	2.05013614
11	Mismatch repair_Homo sapiens_hsa03430	1.96767658
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95637322
13	RNA degradation_Homo sapiens_hsa03018	1.85636305
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.83381928
15	Propanoate metabolism_Homo sapiens_hsa00640	1.80589641
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75875463
17	Regulation of autophagy_Homo sapiens_hsa04140	1.69254740
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.62007944
19	Phototransduction_Homo sapiens_hsa04744	1.61676463
20	RNA transport_Homo sapiens_hsa03013	1.57441673
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.49963468
22	One carbon pool by folate_Homo sapiens_hsa00670	1.41527543
23	p53 signaling pathway_Homo sapiens_hsa04115	1.40460178
24	Base excision repair_Homo sapiens_hsa03410	1.39186076
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35259147
26	Measles_Homo sapiens_hsa05162	1.35044320
27	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.34383746
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33352099
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.33103247
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.29889836
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.26419874
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26262993
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.25115727
34	Allograft rejection_Homo sapiens_hsa05330	1.23596375
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.23573670
36	Legionellosis_Homo sapiens_hsa05134	1.21127407
37	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.18158751
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14525224
39	Type I diabetes mellitus_Homo sapiens_hsa04940	1.12267039
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12039156
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.11727295
42	Herpes simplex infection_Homo sapiens_hsa05168	1.10903605
43	Asthma_Homo sapiens_hsa05310	1.07740784
44	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.03727311
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01823254
46	Cell cycle_Homo sapiens_hsa04110	0.96239898
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.95636026
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92313425
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.91882625
50	Butanoate metabolism_Homo sapiens_hsa00650	0.91805539
51	Spliceosome_Homo sapiens_hsa03040	0.90680046
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.87113436
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86066227
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84897382
55	DNA replication_Homo sapiens_hsa03030	0.84091135
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83698049
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.82221173
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82107520
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.81573118
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78982575
61	Peroxisome_Homo sapiens_hsa04146	0.78766239
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77408092
63	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.77080268
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73013350
65	Parkinsons disease_Homo sapiens_hsa05012	0.70959318
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.69581512
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68734654
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67635013
69	Sulfur metabolism_Homo sapiens_hsa00920	0.66825502
70	Purine metabolism_Homo sapiens_hsa00230	0.66025804
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.64288609
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.63214084
73	Influenza A_Homo sapiens_hsa05164	0.63008362
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62339821
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61013013
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60505993
77	Circadian rhythm_Homo sapiens_hsa04710	0.60502366
78	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57835721
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55825028
80	Olfactory transduction_Homo sapiens_hsa04740	0.55072182
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54807723
82	Huntingtons disease_Homo sapiens_hsa05016	0.53088850
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52798309
84	Caffeine metabolism_Homo sapiens_hsa00232	0.52435792
85	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.51843364
86	Leishmaniasis_Homo sapiens_hsa05140	0.51261872
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51064593
88	African trypanosomiasis_Homo sapiens_hsa05143	0.50296769
89	Mineral absorption_Homo sapiens_hsa04978	0.49448460
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48464713
91	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.48227796
92	Hepatitis B_Homo sapiens_hsa05161	0.47949344
93	TNF signaling pathway_Homo sapiens_hsa04668	0.46628946
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45320311
95	Fatty acid elongation_Homo sapiens_hsa00062	0.45186299
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43146036
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.42049468
98	Oocyte meiosis_Homo sapiens_hsa04114	0.40365996
99	Tuberculosis_Homo sapiens_hsa05152	0.40146056
100	Metabolic pathways_Homo sapiens_hsa01100	0.35097748

ZNF701

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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