ZNF704

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.18476873
2presynaptic membrane organization (GO:0097090)3.76639183
3cell migration in hindbrain (GO:0021535)3.59464406
4limb bud formation (GO:0060174)3.53519389
5postsynaptic membrane organization (GO:0001941)3.52590047
6central nervous system projection neuron axonogenesis (GO:0021952)3.46732289
7axonal fasciculation (GO:0007413)3.44374919
8neuron recognition (GO:0008038)3.36607166
9pyrimidine nucleobase catabolic process (GO:0006208)3.28773828
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26515963
11neurotransmitter-gated ion channel clustering (GO:0072578)3.11863850
12cerebral cortex radially oriented cell migration (GO:0021799)3.11513557
13neuron cell-cell adhesion (GO:0007158)3.10975654
14vocalization behavior (GO:0071625)3.07290545
15embryonic retina morphogenesis in camera-type eye (GO:0060059)3.06376524
16establishment of nucleus localization (GO:0040023)3.04054055
17positive regulation of dendritic spine morphogenesis (GO:0061003)3.00451656
18dendrite morphogenesis (GO:0048813)2.99696515
19cardiac chamber formation (GO:0003207)2.98348564
20layer formation in cerebral cortex (GO:0021819)2.96239908
21auditory behavior (GO:0031223)2.94358328
22negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88743224
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88478836
24central nervous system neuron axonogenesis (GO:0021955)2.87711190
25cardiac ventricle formation (GO:0003211)2.84627779
26sympathetic nervous system development (GO:0048485)2.84461715
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80583464
28dendritic spine morphogenesis (GO:0060997)2.76190226
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75892573
30neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.75322709
31myelination in peripheral nervous system (GO:0022011)2.67980139
32peripheral nervous system axon ensheathment (GO:0032292)2.67980139
33ionotropic glutamate receptor signaling pathway (GO:0035235)2.67669674
34nucleus localization (GO:0051647)2.66397276
35regulation of axon extension involved in axon guidance (GO:0048841)2.65240121
36appendage development (GO:0048736)2.65116008
37limb development (GO:0060173)2.65116008
38regulation of axon guidance (GO:1902667)2.62291849
39nucleobase catabolic process (GO:0046113)2.55532914
40cardiac myofibril assembly (GO:0055003)2.55267773
41positive regulation of synapse maturation (GO:0090129)2.54588365
42protein localization to synapse (GO:0035418)2.53012950
43cerebellar granule cell differentiation (GO:0021707)2.53008861
44apical protein localization (GO:0045176)2.51613713
45cell communication involved in cardiac conduction (GO:0086065)2.50197271
46response to auditory stimulus (GO:0010996)2.48943797
47regulation of sarcomere organization (GO:0060297)2.48834143
48cell communication by electrical coupling (GO:0010644)2.48137768
49spinal cord development (GO:0021510)2.47751699
50cellular sodium ion homeostasis (GO:0006883)2.46479868
51retinal ganglion cell axon guidance (GO:0031290)2.45818345
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44269485
53regulation of dendritic spine morphogenesis (GO:0061001)2.44233528
54mechanosensory behavior (GO:0007638)2.43141728
55regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42713766
56positive regulation of dendrite morphogenesis (GO:0050775)2.42347704
57neuromuscular synaptic transmission (GO:0007274)2.42109020
58membrane depolarization during action potential (GO:0086010)2.41393922
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.41253981
60axon ensheathment in central nervous system (GO:0032291)2.41154916
61central nervous system myelination (GO:0022010)2.41154916
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.39857808
63cranial nerve morphogenesis (GO:0021602)2.38399347
64glutamate receptor signaling pathway (GO:0007215)2.38054482
65synaptic vesicle docking involved in exocytosis (GO:0016081)2.35758812
66retina layer formation (GO:0010842)2.34785203
67synapse assembly (GO:0007416)2.34777106
68regulation of pigment cell differentiation (GO:0050932)2.31544871
69regulation of synapse maturation (GO:0090128)2.30988880
70cerebral cortex cell migration (GO:0021795)2.30104125
71transmission of nerve impulse (GO:0019226)2.29995884
72regulation of synapse assembly (GO:0051963)2.29433885
73positive regulation of dendrite development (GO:1900006)2.28517464
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28189932
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.28106386
76neuronal ion channel clustering (GO:0045161)2.28039804
77membrane assembly (GO:0071709)2.27771151
78positive regulation of dendritic spine development (GO:0060999)2.27306146
79establishment of mitochondrion localization (GO:0051654)2.26953277
80negative regulation of dendrite development (GO:2000171)2.23399661
81synaptic transmission, glutamatergic (GO:0035249)2.22540275
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21039181
83myofibril assembly (GO:0030239)2.20951232
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20429951
85axon extension (GO:0048675)2.20382945
86artery development (GO:0060840)2.19779712
87heart morphogenesis (GO:0003007)2.19645008
88regulation of dendrite morphogenesis (GO:0048814)2.19292279
89myotube differentiation (GO:0014902)2.19184978
90regulation of synapse structural plasticity (GO:0051823)2.18835679
91mitochondrion transport along microtubule (GO:0047497)2.16765663
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.16765663
93asymmetric protein localization (GO:0008105)2.16363604
94regulation of dendritic spine development (GO:0060998)2.14978762
95embryonic foregut morphogenesis (GO:0048617)2.14002855
96regulation of synapse organization (GO:0050807)2.13903944
97regulation of glutamate receptor signaling pathway (GO:1900449)2.13731558
98synapse organization (GO:0050808)2.13618437
99inner ear receptor stereocilium organization (GO:0060122)2.12057111
100gastrulation with mouth forming second (GO:0001702)2.11944720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59056795
2GBX2_23144817_ChIP-Seq_PC3_Human3.23039499
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.01487510
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51844185
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34843998
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.28133519
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26044990
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19372899
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01682361
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01291987
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.00298797
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99849417
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99849417
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95487484
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94147628
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.91987057
17* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90371585
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88401821
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.87601566
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86099131
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.85405350
22DROSHA_22980978_ChIP-Seq_HELA_Human1.80859546
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76486181
24AR_21572438_ChIP-Seq_LNCaP_Human1.75212331
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74329765
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73062755
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70531825
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69225983
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69206404
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68947296
31SMAD4_21799915_ChIP-Seq_A2780_Human1.68665806
32TAF15_26573619_Chip-Seq_HEK293_Human1.67613840
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63082191
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.62851502
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58093953
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.57758981
37REST_21632747_ChIP-Seq_MESCs_Mouse1.57420917
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.54946075
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54316034
40AHR_22903824_ChIP-Seq_MCF-7_Human1.51353324
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.50573932
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49661181
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49661181
44FUS_26573619_Chip-Seq_HEK293_Human1.49034164
45RNF2_27304074_Chip-Seq_NSC_Mouse1.48454617
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47110068
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46206170
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44873756
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43973368
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43672404
51P300_19829295_ChIP-Seq_ESCs_Human1.43505192
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43489078
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41282644
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.40781882
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40009287
56IGF1R_20145208_ChIP-Seq_DFB_Human1.39745072
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39294716
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38304335
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36399927
60STAT3_23295773_ChIP-Seq_U87_Human1.36115958
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34938831
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33653990
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32963180
64* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32744373
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.31055032
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30634804
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29857863
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29752361
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.29361316
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.29101265
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27998080
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27131854
73* TCF4_23295773_ChIP-Seq_U87_Human1.26489653
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.25680526
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25606478
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23769817
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21970621
78AR_19668381_ChIP-Seq_PC3_Human1.20873064
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19432743
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.18992488
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18591566
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17363088
83* AR_25329375_ChIP-Seq_VCAP_Human1.16999739
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16360716
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16202959
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15962187
87SOX9_26525672_Chip-Seq_HEART_Mouse1.15955310
88TP53_16413492_ChIP-PET_HCT116_Human1.14470627
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11908248
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.07340868
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06255181
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.05873894
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.04208189
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.03712300
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02806776
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.01926019
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01765465
98ER_23166858_ChIP-Seq_MCF-7_Human1.01424633
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.00729036
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00538334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.66930322
2MP0004270_analgesia2.67045245
3MP0004859_abnormal_synaptic_plasticity2.44825431
4MP0000778_abnormal_nervous_system2.31908835
5MP0003880_abnormal_central_pattern2.15304408
6MP0004145_abnormal_muscle_electrophysio2.00295461
7MP0005423_abnormal_somatic_nervous1.99764109
8MP0001486_abnormal_startle_reflex1.88523848
9MP0003635_abnormal_synaptic_transmissio1.84269384
10MP0005248_abnormal_Harderian_gland1.82044761
11MP0002735_abnormal_chemical_nociception1.74213610
12MP0002638_abnormal_pupillary_reflex1.73871052
13MP0002734_abnormal_mechanical_nocicepti1.72483349
14MP0005187_abnormal_penis_morphology1.65474137
15MP0000566_synostosis1.63681036
16MP0005409_darkened_coat_color1.62067648
17MP0003136_yellow_coat_color1.59918231
18MP0002063_abnormal_learning/memory/cond1.59833196
19MP0000534_abnormal_ureter_morphology1.54191589
20MP0005670_abnormal_white_adipose1.49990754
21MP0005171_absent_coat_pigmentation1.45467656
22MP0000955_abnormal_spinal_cord1.43691488
23MP0001346_abnormal_lacrimal_gland1.43434236
24MP0002184_abnormal_innervation1.41046114
25MP0000569_abnormal_digit_pigmentation1.40565139
26MP0009745_abnormal_behavioral_response1.36172649
27MP0002557_abnormal_social/conspecific_i1.35065031
28MP0005646_abnormal_pituitary_gland1.35015711
29MP0000631_abnormal_neuroendocrine_gland1.34547547
30MP0002272_abnormal_nervous_system1.34473758
31MP0002064_seizures1.34355140
32MP0001984_abnormal_olfaction1.33094595
33MP0002572_abnormal_emotion/affect_behav1.30421402
34MP0002249_abnormal_larynx_morphology1.29455493
35MP0009046_muscle_twitch1.29088675
36MP0000537_abnormal_urethra_morphology1.26215379
37MP0002697_abnormal_eye_size1.21966937
38MP0002882_abnormal_neuron_morphology1.21271445
39MP0006276_abnormal_autonomic_nervous1.20638176
40MP0004885_abnormal_endolymph1.18172147
41MP0001299_abnormal_eye_distance/1.14573034
42MP0002067_abnormal_sensory_capabilities1.14376159
43MP0005551_abnormal_eye_electrophysiolog1.12892425
44MP0009780_abnormal_chondrocyte_physiolo1.12889245
45MP0005386_behavior/neurological_phenoty1.12659836
46MP0004924_abnormal_behavior1.12659836
47MP0003861_abnormal_nervous_system1.11683322
48MP0002751_abnormal_autonomic_nervous1.11081450
49MP0001188_hyperpigmentation1.10172154
50MP0010368_abnormal_lymphatic_system1.09930238
51MP0003890_abnormal_embryonic-extraembry1.09287377
52MP0002909_abnormal_adrenal_gland1.08161621
53MP0005253_abnormal_eye_physiology1.08031111
54MP0002234_abnormal_pharynx_morphology1.07384687
55MP0001968_abnormal_touch/_nociception1.07089420
56MP0002152_abnormal_brain_morphology1.06055438
57MP0003937_abnormal_limbs/digits/tail_de1.04912558
58MP0002108_abnormal_muscle_morphology1.04137319
59MP0002233_abnormal_nose_morphology1.03583024
60MP0004084_abnormal_cardiac_muscle1.03391368
61MP0003385_abnormal_body_wall1.03176534
62MP0000751_myopathy1.02785994
63MP0001485_abnormal_pinna_reflex1.02625236
64MP0002009_preneoplasia1.02240933
65MP0002752_abnormal_somatic_nervous1.01934797
66MP0004215_abnormal_myocardial_fiber1.01354825
67MP0004742_abnormal_vestibular_system1.00771125
68MP0001177_atelectasis0.99798372
69MP0002102_abnormal_ear_morphology0.99383283
70MP0003122_maternal_imprinting0.98929810
71MP0001970_abnormal_pain_threshold0.98398585
72MP0003935_abnormal_craniofacial_develop0.97718188
73MP0004811_abnormal_neuron_physiology0.97489056
74MP0001501_abnormal_sleep_pattern0.97213602
75MP0002733_abnormal_thermal_nociception0.97151366
76MP0005503_abnormal_tendon_morphology0.95912948
77MP0002938_white_spotting0.94273437
78MP0001502_abnormal_circadian_rhythm0.93943605
79MP0002736_abnormal_nociception_after0.93637296
80MP0000049_abnormal_middle_ear0.93216702
81MP0003942_abnormal_urinary_system0.92410975
82MP0003938_abnormal_ear_development0.92315671
83MP0004043_abnormal_pH_regulation0.90518858
84MP0004085_abnormal_heartbeat0.90434642
85MP0003755_abnormal_palate_morphology0.89246091
86MP0003878_abnormal_ear_physiology0.89060636
87MP0005377_hearing/vestibular/ear_phenot0.89060636
88MP0010030_abnormal_orbit_morphology0.88107916
89MP0008569_lethality_at_weaning0.88047209
90MP0001286_abnormal_eye_development0.86884647
91MP0000026_abnormal_inner_ear0.86018594
92MP0003119_abnormal_digestive_system0.85677202
93MP0001879_abnormal_lymphatic_vessel0.85503070
94MP0000383_abnormal_hair_follicle0.84999717
95MP0002116_abnormal_craniofacial_bone0.83595429
96MP0000462_abnormal_digestive_system0.82892997
97MP0003567_abnormal_fetal_cardiomyocyte0.82847276
98MP0005195_abnormal_posterior_eye0.82487415
99MP0006138_congestive_heart_failure0.79470322
100MP0005391_vision/eye_phenotype0.79389049

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.02104787
2Cutaneous finger syndactyly (HP:0010554)3.01603764
3Genetic anticipation (HP:0003743)2.96307172
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.89145540
5Short 4th metacarpal (HP:0010044)2.86737542
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86737542
7Abnormality of the ischium (HP:0003174)2.84900430
8Focal motor seizures (HP:0011153)2.73750885
9Hepatoblastoma (HP:0002884)2.69357543
10Focal seizures (HP:0007359)2.66277302
11Progressive cerebellar ataxia (HP:0002073)2.60786843
12Cutaneous syndactyly (HP:0012725)2.59722295
13Neoplasm of the heart (HP:0100544)2.59534147
14Alacrima (HP:0000522)2.54433419
15Broad-based gait (HP:0002136)2.53284737
16Abnormality of the pubic bones (HP:0003172)2.48953545
17Drooling (HP:0002307)2.43453187
18Midline defect of the nose (HP:0004122)2.43349859
19Blue irides (HP:0000635)2.32517250
20Aplasia/Hypoplasia of the sternum (HP:0006714)2.32420702
21Hypoplastic ischia (HP:0003175)2.31831138
22Myokymia (HP:0002411)2.30613976
23Megalencephaly (HP:0001355)2.29992173
24Abnormality of the 4th metacarpal (HP:0010012)2.27312520
25Volvulus (HP:0002580)2.21607182
26Action tremor (HP:0002345)2.19209859
27Decreased lacrimation (HP:0000633)2.16921050
28Excessive salivation (HP:0003781)2.13024550
29Absent speech (HP:0001344)2.12706380
30Pheochromocytoma (HP:0002666)2.10648891
31Febrile seizures (HP:0002373)2.06960043
32Renal hypoplasia (HP:0000089)2.04127782
33Limited hip movement (HP:0008800)1.98280329
34Papillary thyroid carcinoma (HP:0002895)1.95338467
35Exotropia (HP:0000577)1.94629232
36Renovascular hypertension (HP:0100817)1.94243234
37Vitreoretinal degeneration (HP:0000655)1.92316575
38Bicornuate uterus (HP:0000813)1.88901994
39Gaze-evoked nystagmus (HP:0000640)1.88723311
40Abnormality of the aortic arch (HP:0012303)1.83987318
41Epileptic encephalopathy (HP:0200134)1.79762572
42Absent eyebrow (HP:0002223)1.78508688
43Tubulointerstitial nephritis (HP:0001970)1.76151815
44Heterotopia (HP:0002282)1.76050573
45Morphological abnormality of the middle ear (HP:0008609)1.75658436
46Laryngomalacia (HP:0001601)1.74079577
47Syncope (HP:0001279)1.71493855
48Abnormality of the calf musculature (HP:0001430)1.70830758
49Cupped ear (HP:0000378)1.69725884
50Astrocytoma (HP:0009592)1.69156664
51Abnormality of the astrocytes (HP:0100707)1.69156664
52Long clavicles (HP:0000890)1.68121986
53Vaginal atresia (HP:0000148)1.68035358
54Truncal obesity (HP:0001956)1.66599829
55High anterior hairline (HP:0009890)1.65987364
56Neoplasm of the oral cavity (HP:0100649)1.65415492
57Genital tract atresia (HP:0001827)1.65267837
58Bundle branch block (HP:0011710)1.65175681
59Protruding tongue (HP:0010808)1.64008778
60Thick eyebrow (HP:0000574)1.61844466
61Aplasia involving bones of the extremities (HP:0009825)1.61504391
62Aplasia involving bones of the upper limbs (HP:0009823)1.61504391
63Aplasia of the phalanges of the hand (HP:0009802)1.61504391
64Hip contracture (HP:0003273)1.61494973
65Oligodactyly (hands) (HP:0001180)1.59567645
66Macroorchidism (HP:0000053)1.58272320
67Obsessive-compulsive behavior (HP:0000722)1.57828242
68Tented upper lip vermilion (HP:0010804)1.57417547
69Atonic seizures (HP:0010819)1.57354225
70Abnormality of the lower motor neuron (HP:0002366)1.57136059
71Shawl scrotum (HP:0000049)1.56307698
72Prolonged QT interval (HP:0001657)1.55286307
73Sudden death (HP:0001699)1.54926780
74Gastroesophageal reflux (HP:0002020)1.54880385
75Urinary bladder sphincter dysfunction (HP:0002839)1.54575919
76Thickened helices (HP:0000391)1.50575803
77Bell-shaped thorax (HP:0001591)1.49910732
78Truncal ataxia (HP:0002078)1.47976105
79Lymphangioma (HP:0100764)1.47179561
80Neonatal short-limb short stature (HP:0008921)1.47172871
81Anophthalmia (HP:0000528)1.46816203
82Hypoplastic nipples (HP:0002557)1.45687461
83Bronchomalacia (HP:0002780)1.45668089
84Preaxial foot polydactyly (HP:0001841)1.45221179
85Omphalocele (HP:0001539)1.45199231
86Intestinal atresia (HP:0011100)1.44786660
87Wide anterior fontanel (HP:0000260)1.44491442
88Germ cell neoplasia (HP:0100728)1.44270505
89Hypoplasia of the iris (HP:0007676)1.43752125
90Glioma (HP:0009733)1.42543962
91Tracheomalacia (HP:0002779)1.42363489
92Epileptiform EEG discharges (HP:0011182)1.42351073
93Neuroendocrine neoplasm (HP:0100634)1.42284051
94Sacral dimple (HP:0000960)1.41767458
95Aqueductal stenosis (HP:0002410)1.41107934
96Impaired social interactions (HP:0000735)1.39603112
97Abnormal social behavior (HP:0012433)1.39603112
98Abnormality of the diencephalon (HP:0010662)1.39079062
99Atrial fibrillation (HP:0005110)1.37780109
100Gait imbalance (HP:0002141)1.37473591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.55739921
2CASK4.29421398
3LATS12.47133964
4AKT32.43057246
5TNIK2.38042204
6NTRK22.34956881
7MAP3K42.11563487
8EPHA42.03661857
9FRK2.02275518
10CAMK1G1.99185286
11NTRK31.85679200
12CAMK1D1.80778790
13PNCK1.72745904
14SGK21.71143372
15INSRR1.64675903
16MAPK131.62119602
17STK38L1.59263729
18PKN21.56775948
19SGK4941.56727353
20SGK2231.56727353
21OBSCN1.55739430
22FGFR21.55671961
23SIK21.52772096
24WNK31.39678238
25EPHA31.34028477
26DMPK1.31198821
27EPHB21.27431405
28RIPK11.19448670
29MAP2K71.16885086
30TYRO31.11537568
31STK391.11092988
32SGK31.06299953
33NTRK11.05867425
34EEF2K1.03847096
35ERBB21.02154799
36LATS21.00111475
37CDK120.99946370
38UHMK10.99110707
39MKNK20.98562447
40BCR0.98105712
41MINK10.96591692
42CAMK40.93015085
43MAP2K40.90333073
44PINK10.88190106
45PDGFRA0.87985743
46PIK3CA0.87400305
47CAMKK10.85428939
48RET0.85279100
49ICK0.84447077
50CCNB10.84016643
51BMPR1B0.83989182
52PRKD30.83547058
53CDK50.82567015
54BRD40.81934164
55MAP3K100.77973439
56DYRK20.76074805
57CAMK10.75730275
58ERBB30.75435372
59DDR20.75305485
60PHKG10.73811056
61PHKG20.73811056
62DAPK20.73735333
63WNK10.72559222
64MAPK150.72409261
65SGK10.71922327
66DYRK1A0.71342364
67FGFR10.69064975
68MARK20.67373665
69PRKAA10.67015735
70MAP4K20.66490576
71WEE10.65624349
72CDK30.65299857
73MET0.65283773
74PAK30.64570697
75PKN10.64469024
76FER0.63555799
77CSNK1G20.63529025
78PRKCG0.62471526
79MTOR0.61108806
80PDGFRB0.60164456
81CAMK2A0.59256084
82PRKCH0.54851764
83CSNK1A1L0.54673072
84MAPK100.53130545
85MAP3K70.53108401
86RPS6KA30.51777759
87CAMK2B0.51558501
88NLK0.51216578
89CSNK1G10.50527480
90CSNK1E0.49852844
91CSNK1D0.48398273
92PRKCE0.48216244
93DYRK1B0.47661033
94GSK3B0.47461438
95KSR10.45922217
96STK110.45873271
97PRKCZ0.45492066
98STK380.44163531
99ROCK10.44152696
100PRKAA20.44138748

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.93523344
2Glutamatergic synapse_Homo sapiens_hsa047242.06877901
3Circadian entrainment_Homo sapiens_hsa047131.99096456
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84952897
5Axon guidance_Homo sapiens_hsa043601.78552918
6Cocaine addiction_Homo sapiens_hsa050301.69301335
7Dilated cardiomyopathy_Homo sapiens_hsa054141.66250430
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63562149
9GABAergic synapse_Homo sapiens_hsa047271.62869307
10Dopaminergic synapse_Homo sapiens_hsa047281.61058470
11Taste transduction_Homo sapiens_hsa047421.60098623
12Amphetamine addiction_Homo sapiens_hsa050311.58932098
13Morphine addiction_Homo sapiens_hsa050321.56678341
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53095806
15Insulin secretion_Homo sapiens_hsa049111.52077276
16Circadian rhythm_Homo sapiens_hsa047101.51325566
17Cholinergic synapse_Homo sapiens_hsa047251.48614758
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43406637
19Basal cell carcinoma_Homo sapiens_hsa052171.43012331
20Renin secretion_Homo sapiens_hsa049241.40709630
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37860702
22Long-term potentiation_Homo sapiens_hsa047201.35792138
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33348242
24Hippo signaling pathway_Homo sapiens_hsa043901.31294779
25cAMP signaling pathway_Homo sapiens_hsa040241.30897717
26Hedgehog signaling pathway_Homo sapiens_hsa043401.30267926
27Melanogenesis_Homo sapiens_hsa049161.29290231
28Lysine degradation_Homo sapiens_hsa003101.23118662
29Adherens junction_Homo sapiens_hsa045201.22592133
30Gastric acid secretion_Homo sapiens_hsa049711.22466868
31Endometrial cancer_Homo sapiens_hsa052131.21643778
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21008338
33Salivary secretion_Homo sapiens_hsa049701.20909802
34Oxytocin signaling pathway_Homo sapiens_hsa049211.18306156
35Long-term depression_Homo sapiens_hsa047301.15211429
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14579530
37Calcium signaling pathway_Homo sapiens_hsa040201.14477768
38ErbB signaling pathway_Homo sapiens_hsa040121.12877298
39Dorso-ventral axis formation_Homo sapiens_hsa043201.11755133
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10952013
41Gap junction_Homo sapiens_hsa045401.08977344
42Tight junction_Homo sapiens_hsa045301.08658078
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.08573110
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07609400
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06730073
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04154875
47Estrogen signaling pathway_Homo sapiens_hsa049151.04127843
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03532340
49Glioma_Homo sapiens_hsa052141.02514033
50Wnt signaling pathway_Homo sapiens_hsa043100.99667042
51Pancreatic secretion_Homo sapiens_hsa049720.95685550
52Protein digestion and absorption_Homo sapiens_hsa049740.94858470
53Histidine metabolism_Homo sapiens_hsa003400.94618313
54Bile secretion_Homo sapiens_hsa049760.94607690
55Serotonergic synapse_Homo sapiens_hsa047260.93478229
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93044919
57Type II diabetes mellitus_Homo sapiens_hsa049300.91356803
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.90630263
59Colorectal cancer_Homo sapiens_hsa052100.90046788
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89740986
61Fatty acid biosynthesis_Homo sapiens_hsa000610.88242105
62TGF-beta signaling pathway_Homo sapiens_hsa043500.87629622
63Synaptic vesicle cycle_Homo sapiens_hsa047210.87502345
64Phototransduction_Homo sapiens_hsa047440.86917207
65Choline metabolism in cancer_Homo sapiens_hsa052310.86192533
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86066388
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84343762
68ECM-receptor interaction_Homo sapiens_hsa045120.82905596
69ABC transporters_Homo sapiens_hsa020100.81245815
70Notch signaling pathway_Homo sapiens_hsa043300.80388432
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80117677
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79000881
73Ovarian steroidogenesis_Homo sapiens_hsa049130.77798238
74GnRH signaling pathway_Homo sapiens_hsa049120.76405310
75MicroRNAs in cancer_Homo sapiens_hsa052060.75066065
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74373236
77AMPK signaling pathway_Homo sapiens_hsa041520.74235027
78Thyroid hormone synthesis_Homo sapiens_hsa049180.73358946
79Renal cell carcinoma_Homo sapiens_hsa052110.70456519
80Propanoate metabolism_Homo sapiens_hsa006400.69940495
81Prostate cancer_Homo sapiens_hsa052150.69567806
82Focal adhesion_Homo sapiens_hsa045100.69257041
83Rap1 signaling pathway_Homo sapiens_hsa040150.66718217
84Inositol phosphate metabolism_Homo sapiens_hsa005620.65894242
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64654029
86Cardiac muscle contraction_Homo sapiens_hsa042600.64047089
87Ras signaling pathway_Homo sapiens_hsa040140.60595181
88Glucagon signaling pathway_Homo sapiens_hsa049220.59875251
89Melanoma_Homo sapiens_hsa052180.59690971
90Olfactory transduction_Homo sapiens_hsa047400.59655629
91Alcoholism_Homo sapiens_hsa050340.55779867
92Prolactin signaling pathway_Homo sapiens_hsa049170.55756767
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.54349475
94Oocyte meiosis_Homo sapiens_hsa041140.54124493
95FoxO signaling pathway_Homo sapiens_hsa040680.53776983
96Insulin signaling pathway_Homo sapiens_hsa049100.53395621
97PPAR signaling pathway_Homo sapiens_hsa033200.52591751
98MAPK signaling pathway_Homo sapiens_hsa040100.52483685
99mTOR signaling pathway_Homo sapiens_hsa041500.51352303
100Pathways in cancer_Homo sapiens_hsa052000.50527665

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