ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K9 demethylation (GO:0033169)	7.74585298
2	high-density lipoprotein particle remodeling (GO:0034375)	5.50659131
3	multicellular organism reproduction (GO:0032504)	5.49531041
4	histone H3-K36 demethylation (GO:0070544)	5.18966261
5	positive regulation of catecholamine secretion (GO:0033605)	5.05924101
6	histone lysine demethylation (GO:0070076)	4.69394696
7	reverse cholesterol transport (GO:0043691)	4.62246305
8	histone demethylation (GO:0016577)	4.55846839
9	regulation of acrosome reaction (GO:0060046)	4.49937656
10	oocyte development (GO:0048599)	4.41906950
11	regulation of triglyceride catabolic process (GO:0010896)	4.25420319
12	protein demethylation (GO:0006482)	4.17733958
13	protein dealkylation (GO:0008214)	4.17733958
14	melanin biosynthetic process (GO:0042438)	4.11490881
15	single fertilization (GO:0007338)	4.10443779
16	epithelial cilium movement (GO:0003351)	3.95369313
17	very-low-density lipoprotein particle assembly (GO:0034379)	3.94760282
18	phospholipid efflux (GO:0033700)	3.93393784
19	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.93243078
20	glutamine family amino acid biosynthetic process (GO:0009084)	3.92503332
21	melanin metabolic process (GO:0006582)	3.82743150
22	binding of sperm to zona pellucida (GO:0007339)	3.78229388
23	N-terminal protein amino acid acetylation (GO:0006474)	3.75143299
24	male meiosis I (GO:0007141)	3.72256298
25	reproduction (GO:0000003)	3.71234437
26	negative regulation of Ras GTPase activity (GO:0034261)	3.70755398
27	regulation of Rac protein signal transduction (GO:0035020)	3.65524107
28	plasma lipoprotein particle assembly (GO:0034377)	3.54184719
29	protein kinase C signaling (GO:0070528)	3.46268370
30	myoblast migration (GO:0051451)	3.40231126
31	cilium movement (GO:0003341)	3.39754002
32	cellular response to zinc ion (GO:0071294)	3.38715455
33	secondary metabolite biosynthetic process (GO:0044550)	3.37068931
34	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.35487414
35	sperm-egg recognition (GO:0035036)	3.32727294
36	regulation of DNA endoreduplication (GO:0032875)	3.30787330
37	behavioral response to nicotine (GO:0035095)	3.30772293
38	cholesterol efflux (GO:0033344)	3.25474353
39	dicarboxylic acid catabolic process (GO:0043649)	3.22413332
40	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.22027564
41	ventricular system development (GO:0021591)	3.15400634
42	spermatid development (GO:0007286)	3.12785347
43	DNA double-strand break processing (GO:0000729)	3.11020776
44	plasma lipoprotein particle remodeling (GO:0034369)	3.09753276
45	protein-lipid complex remodeling (GO:0034368)	3.09753276
46	macromolecular complex remodeling (GO:0034367)	3.09753276
47	aggressive behavior (GO:0002118)	3.08720347
48	acrosome reaction (GO:0007340)	3.06448088
49	male meiosis (GO:0007140)	3.03759553
50	fertilization (GO:0009566)	3.03683208
51	pentose metabolic process (GO:0019321)	3.02605197
52	negative regulation of organelle assembly (GO:1902116)	3.02462837
53	central nervous system myelination (GO:0022010)	2.98844151
54	axon ensheathment in central nervous system (GO:0032291)	2.98844151
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97489557
56	motile cilium assembly (GO:0044458)	2.95815289
57	dopamine transport (GO:0015872)	2.95678351
58	rRNA modification (GO:0000154)	2.95030638
59	sleep (GO:0030431)	2.94926592
60	protein-lipid complex assembly (GO:0065005)	2.94014428
61	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.93974665
62	non-recombinational repair (GO:0000726)	2.91890086
63	double-strand break repair via nonhomologous end joining (GO:0006303)	2.91890086
64	regulation of penile erection (GO:0060405)	2.88465534
65	rRNA methylation (GO:0031167)	2.87940053
66	calcium ion-dependent exocytosis (GO:0017156)	2.87362553
67	positive regulation of prostaglandin secretion (GO:0032308)	2.84362058
68	parental behavior (GO:0060746)	2.82065344
69	transcription from mitochondrial promoter (GO:0006390)	2.81894994
70	positive regulation of digestive system process (GO:0060456)	2.81289283
71	mitotic chromosome condensation (GO:0007076)	2.80369082
72	positive regulation of histone H3-K4 methylation (GO:0051571)	2.79373504
73	regulation of exit from mitosis (GO:0007096)	2.79159093
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78035282
75	piRNA metabolic process (GO:0034587)	2.77339655
76	inositol phosphate catabolic process (GO:0071545)	2.77061715
77	synaptonemal complex organization (GO:0070193)	2.76801037
78	cell-cell recognition (GO:0009988)	2.76590806
79	regulation of female receptivity (GO:0045924)	2.76567078
80	intra-S DNA damage checkpoint (GO:0031573)	2.76465630
81	meiosis I (GO:0007127)	2.75929295
82	N-terminal protein amino acid modification (GO:0031365)	2.70383151
83	inositol phosphate dephosphorylation (GO:0046855)	2.66030299
84	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.66030299
85	regulation of cholesterol esterification (GO:0010872)	2.65645809
86	early endosome to late endosome transport (GO:0045022)	2.64857245
87	potassium ion export (GO:0071435)	2.62451750
88	chaperone-mediated protein complex assembly (GO:0051131)	2.61654297
89	activation of protein kinase B activity (GO:0032148)	2.61618418
90	regulation of neurotransmitter uptake (GO:0051580)	2.60694415
91	DNA replication-dependent nucleosome organization (GO:0034723)	2.60462128
92	DNA replication-dependent nucleosome assembly (GO:0006335)	2.60462128
93	synaptonemal complex assembly (GO:0007130)	2.58233412
94	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.56871123
95	regulation of female gonad development (GO:2000194)	2.55869672
96	regulation of lipoprotein metabolic process (GO:0050746)	2.54831464
97	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.53486476
98	retinal rod cell development (GO:0046548)	2.52909062
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	15.5729082
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	12.8971555

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.15592296
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.50177052
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.44777517
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.44641446
5	VDR_22108803_ChIP-Seq_LS180_Human	3.00440765
6	GATA1_22025678_ChIP-Seq_K562_Human	2.97908152
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.96133085
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.92977208
9	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.87379459
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.85985909
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77567583
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.71956893
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40226116
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.37650463
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01217940
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89312104
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81232688
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79858625
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.78218126
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75573882
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74705487
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67252481
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.63199715
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.58843876
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57467286
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57074507
27	E2F7_22180533_ChIP-Seq_HELA_Human	1.55356726
28	CBP_21632823_ChIP-Seq_H3396_Human	1.54996414
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.51893467
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51893467
31	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.51815714
32	P300_19829295_ChIP-Seq_ESCs_Human	1.50316256
33	RXR_22108803_ChIP-Seq_LS180_Human	1.49832333
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49492792
35	STAT3_23295773_ChIP-Seq_U87_Human	1.49108425
36	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46952331
37	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.46253658
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45775516
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.44104589
40	FUS_26573619_Chip-Seq_HEK293_Human	1.42887723
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42001987
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39500391
43	NCOR_22424771_ChIP-Seq_293T_Human	1.39063460
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36974407
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36467112
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.35222082
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.34824459
48	TCF4_23295773_ChIP-Seq_U87_Human	1.34810184
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32631754
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30639653
51	EWS_26573619_Chip-Seq_HEK293_Human	1.27549975
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24841833
53	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.24219232
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24197562
55	TBL1_22424771_ChIP-Seq_293T_Human	1.23846165
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23775541
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23075244
58	AR_25329375_ChIP-Seq_VCAP_Human	1.21597862
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21133798
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20919868
61	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19774248
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19759378
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18604236
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.18255126
65	GATA3_26560356_Chip-Seq_TH2_Human	1.17873662
66	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17721218
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17211493
68	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.14489794
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13548397
70	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.11525992
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10790825
72	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.10142741
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08324674
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.07493353
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06936471
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04363904
77	GATA3_26560356_Chip-Seq_TH1_Human	1.02804493
78	AR_21909140_ChIP-Seq_LNCAP_Human	1.01575214
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01281876
80	NFYB_21822215_ChIP-Seq_K562_Human	1.01189283
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00598591
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00560805
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00515030
84	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.98805643
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98322969
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98322969
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97579822
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96799114
89	TTF2_22483619_ChIP-Seq_HELA_Human	0.95885816
90	CDX2_22108803_ChIP-Seq_LS180_Human	0.94824617
91	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.93330522
92	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93301628
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.93001317
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92297514
95	JUN_21703547_ChIP-Seq_K562_Human	0.90408979
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.89988189
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.88337295
98	ELF5_23300383_ChIP-Seq_T47D_Human	0.88202289
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88066990
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87638694

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	7.03546394
2	MP0000372_irregular_coat_pigmentation	6.03381579
3	MP0003136_yellow_coat_color	5.05449834
4	MP0000015_abnormal_ear_pigmentation	2.99875978
5	MP0003693_abnormal_embryo_hatching	2.75305221
6	MP0003718_maternal_effect	2.37689147
7	MP0006292_abnormal_olfactory_placode	2.29829098
8	MP0005410_abnormal_fertilization	2.16597329
9	MP0010094_abnormal_chromosome_stability	2.12306648
10	MP0005360_urolithiasis	2.07948454
11	MP0000427_abnormal_hair_cycle	1.95680764
12	MP0006072_abnormal_retinal_apoptosis	1.95048416
13	MP0002160_abnormal_reproductive_system	1.89632237
14	MP0008057_abnormal_DNA_replication	1.86931047
15	MP0004147_increased_porphyrin_level	1.85862169
16	MP0002090_abnormal_vision	1.85369626
17	MP0002638_abnormal_pupillary_reflex	1.79647310
18	MP0003283_abnormal_digestive_organ	1.78865924
19	MP0002837_dystrophic_cardiac_calcinosis	1.76322497
20	MP0008058_abnormal_DNA_repair	1.74959552
21	MP0002938_white_spotting	1.70781826
22	MP0004043_abnormal_pH_regulation	1.67615879
23	MP0001929_abnormal_gametogenesis	1.65977821
24	MP0002095_abnormal_skin_pigmentation	1.63515524
25	MP0005174_abnormal_tail_pigmentation	1.62929485
26	MP0002102_abnormal_ear_morphology	1.57229070
27	MP0006036_abnormal_mitochondrial_physio	1.54551402
28	MP0010329_abnormal_lipoprotein_level	1.51193501
29	MP0003646_muscle_fatigue	1.49133879
30	MP0008877_abnormal_DNA_methylation	1.47042941
31	MP0008789_abnormal_olfactory_epithelium	1.39753050
32	MP0004381_abnormal_hair_follicle	1.39495863
33	MP0005645_abnormal_hypothalamus_physiol	1.36595201
34	MP0006276_abnormal_autonomic_nervous	1.34793272
35	MP0003787_abnormal_imprinting	1.32556509
36	MP0005171_absent_coat_pigmentation	1.31326634
37	MP0005075_abnormal_melanosome_morpholog	1.29136082
38	MP0005394_taste/olfaction_phenotype	1.26845853
39	MP0005499_abnormal_olfactory_system	1.26845853
40	MP0005389_reproductive_system_phenotype	1.18678316
41	MP0002210_abnormal_sex_determination	1.18552390
42	MP0002127_abnormal_cardiovascular_syste	1.16378016
43	MP0001502_abnormal_circadian_rhythm	1.14864447
44	MP0001293_anophthalmia	1.12635667
45	MP0005248_abnormal_Harderian_gland	1.11425633
46	MP0001529_abnormal_vocalization	1.09533733
47	MP0003077_abnormal_cell_cycle	1.09165166
48	MP0004233_abnormal_muscle_weight	1.08125286
49	MP0009046_muscle_twitch	1.06813859
50	MP0001968_abnormal_touch/_nociception	1.05347728
51	MP0002396_abnormal_hematopoietic_system	1.04624614
52	MP0003121_genomic_imprinting	1.04457474
53	MP0008961_abnormal_basal_metabolism	1.04052363
54	MP0001664_abnormal_digestion	1.01317653
55	MP0000749_muscle_degeneration	0.99997295
56	MP0001177_atelectasis	0.99345907
57	MP0010368_abnormal_lymphatic_system	0.98157209
58	MP0003699_abnormal_female_reproductive	0.97300595
59	MP0005551_abnormal_eye_electrophysiolog	0.96213761
60	MP0003878_abnormal_ear_physiology	0.95016259
61	MP0005377_hearing/vestibular/ear_phenot	0.95016259
62	MP0001944_abnormal_pancreas_morphology	0.94736662
63	MP0003698_abnormal_male_reproductive	0.94448092
64	MP0003890_abnormal_embryonic-extraembry	0.93398370
65	MP0001324_abnormal_eye_pigmentation	0.93150410
66	MP0005646_abnormal_pituitary_gland	0.92881146
67	MP0004145_abnormal_muscle_electrophysio	0.92524893
68	MP0000569_abnormal_digit_pigmentation	0.92413890
69	MP0003122_maternal_imprinting	0.92359324
70	MP0005253_abnormal_eye_physiology	0.91272146
71	MP0000653_abnormal_sex_gland	0.90279199
72	MP0000371_diluted_coat_color	0.87417286
73	MP0001905_abnormal_dopamine_level	0.86088034
74	MP0000462_abnormal_digestive_system	0.85808067
75	MP0002876_abnormal_thyroid_physiology	0.83861960
76	MP0002734_abnormal_mechanical_nocicepti	0.82596160
77	MP0004142_abnormal_muscle_tone	0.81749314
78	MP0003950_abnormal_plasma_membrane	0.81265201
79	MP0002693_abnormal_pancreas_physiology	0.81254489
80	MP0005408_hypopigmentation	0.81143600
81	MP0002272_abnormal_nervous_system	0.80159272
82	MP0003868_abnormal_feces_composition	0.78549537
83	MP0001986_abnormal_taste_sensitivity	0.77642426
84	MP0004215_abnormal_myocardial_fiber	0.71755937
85	MP0002069_abnormal_eating/drinking_beha	0.71310842
86	MP0002161_abnormal_fertility/fecundity	0.69984883
87	MP0003943_abnormal_hepatobiliary_system	0.69132907
88	MP0001145_abnormal_male_reproductive	0.68711866
89	MP0002751_abnormal_autonomic_nervous	0.65458164
90	MP0001119_abnormal_female_reproductive	0.64409110
91	MP0009379_abnormal_foot_pigmentation	0.63323102
92	MP0001919_abnormal_reproductive_system	0.62977885
93	MP0001730_embryonic_growth_arrest	0.62776544
94	MP0005332_abnormal_amino_acid	0.61555191
95	MP0005220_abnormal_exocrine_pancreas	0.59629843
96	MP0002557_abnormal_social/conspecific_i	0.58838321
97	MP0004270_analgesia	0.57160947
98	MP0002184_abnormal_innervation	0.55382500
99	MP0002233_abnormal_nose_morphology	0.54938982
100	MP0001984_abnormal_olfaction	0.54504745

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal atrophy (HP:0001105)	7.41317385
2	Premature ovarian failure (HP:0008209)	4.03771572
3	Median cleft lip (HP:0000161)	3.84634286
4	Hyperlipoproteinemia (HP:0010980)	3.80128843
5	Cerebellar dysplasia (HP:0007033)	3.58413968
6	Retinal dysplasia (HP:0007973)	3.51804607
7	Hyperglycinemia (HP:0002154)	3.44311797
8	Congenital sensorineural hearing impairment (HP:0008527)	3.37161163
9	Absent/shortened dynein arms (HP:0200106)	3.34621489
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.34621489
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.33919997
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.30458456
13	Pancreatic fibrosis (HP:0100732)	3.25015068
14	Hypobetalipoproteinemia (HP:0003563)	3.18772381
15	Volvulus (HP:0002580)	3.10004111
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.09483868
17	Rhinitis (HP:0012384)	3.03918772
18	Short tibia (HP:0005736)	3.00147237
19	Abnormal respiratory motile cilium physiology (HP:0012261)	2.91470046
20	Type II lissencephaly (HP:0007260)	2.88642644
21	Chronic hepatic failure (HP:0100626)	2.83041979
22	Abnormal ciliary motility (HP:0012262)	2.74318072
23	Nephronophthisis (HP:0000090)	2.67060805
24	Recurrent corneal erosions (HP:0000495)	2.62506339
25	White forelock (HP:0002211)	2.59869802
26	Albinism (HP:0001022)	2.58689963
27	Hypophosphatemic rickets (HP:0004912)	2.57897839
28	Renal Fanconi syndrome (HP:0001994)	2.54206748
29	Abnormality of endocrine pancreas physiology (HP:0012093)	2.42763194
30	Abnormality of the pancreatic islet cells (HP:0006476)	2.42763194
31	Patchy hypopigmentation of hair (HP:0011365)	2.42145246
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.39085367
33	Microglossia (HP:0000171)	2.37086060
34	Hypoplasia of the fovea (HP:0007750)	2.36790533
35	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.36790533
36	Congenital primary aphakia (HP:0007707)	2.36073153
37	True hermaphroditism (HP:0010459)	2.34333114
38	Severe visual impairment (HP:0001141)	2.33215346
39	Aplasia/Hypoplasia of the macula (HP:0008059)	2.26056881
40	Male infertility (HP:0003251)	2.25737876
41	Medial flaring of the eyebrow (HP:0010747)	2.24119220
42	Facial cleft (HP:0002006)	2.23987850
43	Abnormal auditory evoked potentials (HP:0006958)	2.23826494
44	Tubulointerstitial nephritis (HP:0001970)	2.23622231
45	Late onset (HP:0003584)	2.22393518
46	Genital tract atresia (HP:0001827)	2.21457384
47	Gait imbalance (HP:0002141)	2.17451654
48	Gastrointestinal atresia (HP:0002589)	2.16650002
49	Colon cancer (HP:0003003)	2.16501897
50	Abnormality of abdominal situs (HP:0011620)	2.15457588
51	Abdominal situs inversus (HP:0003363)	2.15457588
52	Pancreatic cysts (HP:0001737)	2.13959466
53	Pigmentary retinal degeneration (HP:0001146)	2.13038169
54	High anterior hairline (HP:0009890)	2.12229330
55	Glycosuria (HP:0003076)	2.12181220
56	Abnormality of urine glucose concentration (HP:0011016)	2.12181220
57	Abnormality of midbrain morphology (HP:0002418)	2.11546804
58	Molar tooth sign on MRI (HP:0002419)	2.11546804
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09962557
60	Limb hypertonia (HP:0002509)	2.08872959
61	Sensory axonal neuropathy (HP:0003390)	2.08296432
62	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.08266522
63	Abnormality of the renal medulla (HP:0100957)	2.08220884
64	Episodic fever (HP:0001954)	2.07087111
65	Tetany (HP:0001281)	2.06048733
66	Hypoplasia of the iris (HP:0007676)	2.04095836
67	Prolonged neonatal jaundice (HP:0006579)	2.02342080
68	Dyschromatopsia (HP:0007641)	2.01560391
69	Autoimmune thrombocytopenia (HP:0001973)	1.97595203
70	Chronic bronchitis (HP:0004469)	1.97180889
71	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97110900
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.97110900
73	Microretrognathia (HP:0000308)	1.96499529
74	Lipid accumulation in hepatocytes (HP:0006561)	1.96483953
75	Impulsivity (HP:0100710)	1.94349911
76	Nephrogenic diabetes insipidus (HP:0009806)	1.93722484
77	Intestinal atresia (HP:0011100)	1.92466859
78	Rectal prolapse (HP:0002035)	1.92046084
79	Malnutrition (HP:0004395)	1.91413983
80	Abnormal drinking behavior (HP:0030082)	1.91252984
81	Polydipsia (HP:0001959)	1.91252984
82	Truncal obesity (HP:0001956)	1.90787802
83	Ocular albinism (HP:0001107)	1.90002326
84	Orthostatic hypotension (HP:0001278)	1.89738425
85	Resting tremor (HP:0002322)	1.89245564
86	Increased hepatocellular lipid droplets (HP:0006565)	1.88840885
87	Gonadal dysgenesis (HP:0000133)	1.85415952
88	Short chin (HP:0000331)	1.84526027
89	Abnormality of the fovea (HP:0000493)	1.82629105
90	Abnormality of the incisor (HP:0000676)	1.82433623
91	Abnormality of the nasal septum (HP:0000419)	1.81853983
92	Postaxial foot polydactyly (HP:0001830)	1.81815040
93	Ectopic kidney (HP:0000086)	1.80551537
94	Vaginal atresia (HP:0000148)	1.77011986
95	Stage 5 chronic kidney disease (HP:0003774)	1.76558540
96	Adrenal hypoplasia (HP:0000835)	1.76065588
97	Atonic seizures (HP:0010819)	1.76023835
98	Enlarged kidneys (HP:0000105)	1.76009907
99	Male pseudohermaphroditism (HP:0000037)	1.75538290
100	Ketoacidosis (HP:0001993)	1.72752947

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	3.70998842
2	TNIK	3.40524115
3	MUSK	3.32543158
4	BMPR1B	3.24410189
5	STK38L	3.08157079
6	FRK	3.03125946
7	STK16	2.89999049
8	NLK	2.62462504
9	CDK3	2.57932200
10	MARK3	2.35207868
11	PINK1	2.25387937
12	ACVR1B	1.97436450
13	LATS1	1.96206213
14	EIF2AK3	1.93187684
15	ZAK	1.88685801
16	TAF1	1.81510041
17	NEK2	1.81412556
18	WEE1	1.80857912
19	WNK3	1.78089429
20	MKNK2	1.71178017
21	MYLK	1.60101199
22	NME2	1.50141349
23	RPS6KA4	1.45967047
24	CSNK1G2	1.44495169
25	FGFR2	1.41045347
26	DYRK3	1.35414503
27	BUB1	1.35266806
28	CSNK1G1	1.33944075
29	TESK2	1.33439870
30	MKNK1	1.31453214
31	CSNK1G3	1.27829648
32	TRIM28	1.26612958
33	VRK1	1.24742032
34	EIF2AK1	1.19015448
35	NUAK1	1.12530009
36	SRPK1	1.11642403
37	TLK1	1.06330097
38	LATS2	1.05130318
39	MATK	1.03601401
40	PLK4	1.02560292
41	OBSCN	0.99090024
42	MAP3K9	0.95330053
43	AURKB	0.90453770
44	PLK1	0.89923714
45	IRAK2	0.88539388
46	AURKA	0.86238444
47	GRK6	0.84574140
48	ATR	0.82800059
49	SGK2	0.80656005
50	CSNK1D	0.80590628
51	ERN1	0.77806422
52	PLK3	0.77763208
53	TAOK3	0.77704649
54	ATM	0.76660281
55	MELK	0.75984731
56	TEC	0.74885968
57	NEK6	0.72025852
58	STK38	0.69615023
59	RPS6KA5	0.66665009
60	ITK	0.65285921
61	DMPK	0.65097334
62	NTRK2	0.64393798
63	MAP2K7	0.64354382
64	STK3	0.62031505
65	TGFBR1	0.61969598
66	PRKD3	0.61399604
67	CDK12	0.60209572
68	SGK494	0.60062253
69	SGK223	0.60062253
70	FGR	0.57648071
71	STK39	0.57597060
72	CSNK1A1L	0.56370483
73	MOS	0.53983493
74	MAPK11	0.52632543
75	PLK2	0.50124382
76	CDK4	0.49593821
77	BCKDK	0.49069087
78	MAP3K2	0.47316464
79	CDK7	0.46953207
80	PDK1	0.45624107
81	CAMK4	0.45555910
82	GRK5	0.44524150
83	MAPK15	0.43881417
84	CSNK2A1	0.43776019
85	NTRK3	0.42413928
86	CSNK2A2	0.40528821
87	KIT	0.40039967
88	PAK2	0.39275556
89	BTK	0.38703474
90	PTK2B	0.37937106
91	MAPK12	0.37847498
92	CDC7	0.36577433
93	MAP2K2	0.35953809
94	CHEK1	0.35321911
95	RAF1	0.34222856
96	GRK1	0.33765488
97	PKN1	0.33176091
98	PIK3CA	0.33143267
99	CHEK2	0.32823880
100	PRKCH	0.32397075

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.81174824
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.37840682
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.31322984
4	Basal transcription factors_Homo sapiens_hsa03022	2.65786183
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.63926430
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.52913988
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.30284802
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29872716
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29688947
10	Fatty acid elongation_Homo sapiens_hsa00062	2.20919101
11	Folate biosynthesis_Homo sapiens_hsa00790	2.12800297
12	Sulfur metabolism_Homo sapiens_hsa00920	1.96243877
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.85389239
14	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79632957
15	RNA polymerase_Homo sapiens_hsa03020	1.76907287
16	mRNA surveillance pathway_Homo sapiens_hsa03015	1.74175719
17	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.74164636
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.68523353
19	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.60942097
20	Glutathione metabolism_Homo sapiens_hsa00480	1.60592472
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60036745
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.54648198
23	DNA replication_Homo sapiens_hsa03030	1.53658253
24	Olfactory transduction_Homo sapiens_hsa04740	1.52545850
25	Homologous recombination_Homo sapiens_hsa03440	1.50743189
26	Butanoate metabolism_Homo sapiens_hsa00650	1.50685696
27	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48565802
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.48034799
29	Oocyte meiosis_Homo sapiens_hsa04114	1.47578278
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46204005
31	Circadian rhythm_Homo sapiens_hsa04710	1.38950437
32	Purine metabolism_Homo sapiens_hsa00230	1.38225428
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.35714272
34	RNA transport_Homo sapiens_hsa03013	1.31232713
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27309159
36	Spliceosome_Homo sapiens_hsa03040	1.21493235
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.20135593
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.19898734
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13136901
40	Mismatch repair_Homo sapiens_hsa03430	1.12811760
41	Cell cycle_Homo sapiens_hsa04110	1.12650280
42	RNA degradation_Homo sapiens_hsa03018	1.10783411
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02880625
44	Phototransduction_Homo sapiens_hsa04744	1.01379041
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98116886
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96264404
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.94822803
48	One carbon pool by folate_Homo sapiens_hsa00670	0.94776936
49	Ribosome_Homo sapiens_hsa03010	0.94486973
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.92993377
51	Alcoholism_Homo sapiens_hsa05034	0.89908013
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86718652
53	Mineral absorption_Homo sapiens_hsa04978	0.77659316
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77004601
55	Taste transduction_Homo sapiens_hsa04742	0.76376260
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.74489908
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73998305
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72424610
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.70790015
60	Renin secretion_Homo sapiens_hsa04924	0.65183767
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.64010422
62	GABAergic synapse_Homo sapiens_hsa04727	0.62512291
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.61470312
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59661951
65	Retinol metabolism_Homo sapiens_hsa00830	0.59507618
66	ABC transporters_Homo sapiens_hsa02010	0.58897065
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.58481331
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57897930
69	Metabolic pathways_Homo sapiens_hsa01100	0.56566001
70	Insulin secretion_Homo sapiens_hsa04911	0.53323891
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53301237
72	Lysine degradation_Homo sapiens_hsa00310	0.52993171
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52734206
74	Regulation of autophagy_Homo sapiens_hsa04140	0.48029133
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47806352
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46929553
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44831644
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43550038
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38084810
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37613658
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.37127784
82	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.36588182
83	Propanoate metabolism_Homo sapiens_hsa00640	0.35793929
84	Prostate cancer_Homo sapiens_hsa05215	0.35534074
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.34479844
86	Circadian entrainment_Homo sapiens_hsa04713	0.32294500
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32223384
88	Parkinsons disease_Homo sapiens_hsa05012	0.31779414
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31614046
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.31015085
91	Tight junction_Homo sapiens_hsa04530	0.29970769
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29846677
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.28514559
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27883526
95	Bile secretion_Homo sapiens_hsa04976	0.27163219
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.26919403
97	Complement and coagulation cascades_Homo sapiens_hsa04610	0.24800822
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.24465381
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23792654
100	Protein export_Homo sapiens_hsa03060	0.22661599

ZNF705E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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