ZNF706

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.23945769
2ATP synthesis coupled proton transport (GO:0015986)5.58912309
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.58912309
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.57036109
5respiratory electron transport chain (GO:0022904)5.16971125
6electron transport chain (GO:0022900)5.07355134
7protein complex biogenesis (GO:0070271)4.76702840
8proteasome assembly (GO:0043248)4.64501797
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60425926
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.60425926
11NADH dehydrogenase complex assembly (GO:0010257)4.60425926
12mitochondrial respiratory chain complex assembly (GO:0033108)4.41495578
13oxidative phosphorylation (GO:0006119)3.82446589
14respiratory chain complex IV assembly (GO:0008535)3.80536564
15protein neddylation (GO:0045116)3.80319363
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.72806816
17cytochrome complex assembly (GO:0017004)3.70310503
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69230321
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69230321
20hydrogen ion transmembrane transport (GO:1902600)3.59284588
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52251607
22chaperone-mediated protein transport (GO:0072321)3.50036288
23rRNA modification (GO:0000154)3.48266572
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47165302
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43980340
26platelet dense granule organization (GO:0060155)3.42777478
27cotranslational protein targeting to membrane (GO:0006613)3.42671703
28termination of RNA polymerase III transcription (GO:0006386)3.41677065
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.41677065
30protein targeting to ER (GO:0045047)3.39371313
31ribosomal small subunit assembly (GO:0000028)3.36624792
32DNA deamination (GO:0045006)3.34844531
33regulation of cellular amino acid metabolic process (GO:0006521)3.33817281
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32976541
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32054801
36protein localization to endoplasmic reticulum (GO:0070972)3.31749128
37ATP biosynthetic process (GO:0006754)3.29688013
38protein-cofactor linkage (GO:0018065)3.29522842
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28429877
40proton transport (GO:0015992)3.28388065
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24707223
42viral transcription (GO:0019083)3.23355156
43hydrogen transport (GO:0006818)3.23030920
44protein targeting to mitochondrion (GO:0006626)3.22941387
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22610570
46cullin deneddylation (GO:0010388)3.20476158
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19840928
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17469677
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17469677
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17464107
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17352379
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17352379
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17352379
54ribosomal large subunit biogenesis (GO:0042273)3.16741428
55translational termination (GO:0006415)3.15406172
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14577766
57pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06941477
58protein localization to mitochondrion (GO:0070585)3.06222262
59establishment of protein localization to mitochondrion (GO:0072655)3.03225175
60preassembly of GPI anchor in ER membrane (GO:0016254)3.03089766
61regulation of mitochondrial translation (GO:0070129)3.01516009
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.00121390
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00089201
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.00089201
65mannosylation (GO:0097502)2.99604232
66positive regulation of mitochondrial fission (GO:0090141)2.99364572
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99282651
68organelle disassembly (GO:1903008)2.96330726
69translation (GO:0006412)2.95305877
70purine nucleotide salvage (GO:0032261)2.93703516
71GPI anchor biosynthetic process (GO:0006506)2.93697484
72negative regulation of ligase activity (GO:0051352)2.93615174
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93615174
74aerobic respiration (GO:0009060)2.87472730
75GPI anchor metabolic process (GO:0006505)2.82798497
76C-terminal protein lipidation (GO:0006501)2.80531118
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80127634
78rRNA methylation (GO:0031167)2.79355952
79translational elongation (GO:0006414)2.77943100
80deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76497402
81protein deneddylation (GO:0000338)2.75194301
82pyrimidine nucleotide catabolic process (GO:0006244)2.74651052
83ATP hydrolysis coupled proton transport (GO:0015991)2.73616807
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.73616807
85deoxyribose phosphate biosynthetic process (GO:0046385)2.72102522
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.72102522
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71817134
88positive regulation of ligase activity (GO:0051351)2.69435596
89anterograde synaptic vesicle transport (GO:0048490)2.67593155
90GTP biosynthetic process (GO:0006183)2.66728649
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65407008
92ribonucleoprotein complex disassembly (GO:0032988)2.65058176
93ribonucleoside triphosphate biosynthetic process (GO:0009201)2.64997618
94purine-containing compound salvage (GO:0043101)2.64684318
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.61829905
96mitochondrial transport (GO:0006839)2.60600982
97peptidyl-histidine modification (GO:0018202)2.60512373
98regulation of cellular amine metabolic process (GO:0033238)2.59766916
99signal peptide processing (GO:0006465)2.59676412
100histone mRNA metabolic process (GO:0008334)2.58214419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.04630484
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.70882085
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.20333539
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.04658548
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75262526
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63802699
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57657944
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29735608
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23718730
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.22999978
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.12570718
12VDR_23849224_ChIP-Seq_CD4+_Human2.92609425
13ELK1_19687146_ChIP-ChIP_HELA_Human2.85447474
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67628033
15FOXP3_21729870_ChIP-Seq_TREG_Human2.44011982
16* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41228644
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33672364
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.31541691
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.29769701
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.16618846
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99237727
22DCP1A_22483619_ChIP-Seq_HELA_Human1.98876000
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87241512
24ZNF274_21170338_ChIP-Seq_K562_Hela1.85147030
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82512549
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74422875
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72708179
28GABP_19822575_ChIP-Seq_HepG2_Human1.70072408
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67621742
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66388299
31* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61534932
32EWS_26573619_Chip-Seq_HEK293_Human1.57196515
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54880794
34VDR_22108803_ChIP-Seq_LS180_Human1.54602135
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53600319
36MYC_18940864_ChIP-ChIP_HL60_Human1.53129878
37* TTF2_22483619_ChIP-Seq_HELA_Human1.51024697
38FUS_26573619_Chip-Seq_HEK293_Human1.47074944
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47000538
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44729270
41IGF1R_20145208_ChIP-Seq_DFB_Human1.40582674
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40339652
43TAF15_26573619_Chip-Seq_HEK293_Human1.40239305
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40111813
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39738475
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38444629
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38336952
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.34275763
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.32658385
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.31669364
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30677105
52XRN2_22483619_ChIP-Seq_HELA_Human1.28743640
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28261396
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22021938
55TP53_22573176_ChIP-Seq_HFKS_Human1.21341941
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21124436
57CIITA_25753668_ChIP-Seq_RAJI_Human1.18298704
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17185314
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16326405
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10157531
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08656390
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08391933
63KDM5A_27292631_Chip-Seq_BREAST_Human1.07482792
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06794408
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06533782
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06346525
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.06346525
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04652235
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03434501
70ER_23166858_ChIP-Seq_MCF-7_Human1.03059100
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.00369774
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00136399
73IRF1_19129219_ChIP-ChIP_H3396_Human0.99044691
74* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98359493
75P300_19829295_ChIP-Seq_ESCs_Human0.97745322
76MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96063703
77PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95872461
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95154161
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94465750
80AR_20517297_ChIP-Seq_VCAP_Human0.93684147
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93144043
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93109016
83ELF5_23300383_ChIP-Seq_T47D_Human0.92610670
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92601795
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92314988
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91575112
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91040936
88* ERG_20517297_ChIP-Seq_VCAP_Human0.90350812
89NCOR_22424771_ChIP-Seq_293T_Human0.90073662
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89562124
91CBP_20019798_ChIP-Seq_JUKART_Human0.89562124
92GATA3_26560356_Chip-Seq_TH2_Human0.88240668
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87631255
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86558709
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85534114
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84843104
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83986828
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83963626
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81789668
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80637511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.93261158
2MP0003880_abnormal_central_pattern2.86609548
3MP0004147_increased_porphyrin_level2.62285202
4MP0006036_abnormal_mitochondrial_physio2.34918038
5MP0005075_abnormal_melanosome_morpholog2.21252101
6MP0001529_abnormal_vocalization2.20764027
7MP0000372_irregular_coat_pigmentation2.18376723
8MP0003787_abnormal_imprinting2.13077957
9MP0008058_abnormal_DNA_repair2.10903887
10MP0009379_abnormal_foot_pigmentation2.07054935
11MP0003186_abnormal_redox_activity1.95324026
12MP0009046_muscle_twitch1.79864961
13MP0005671_abnormal_response_to1.79159964
14MP0005410_abnormal_fertilization1.67501326
15MP0008995_early_reproductive_senescence1.65616613
16MP0008877_abnormal_DNA_methylation1.64625694
17MP0003718_maternal_effect1.60214721
18MP0001968_abnormal_touch/_nociception1.60037239
19MP0002837_dystrophic_cardiac_calcinosis1.59587304
20MP0005646_abnormal_pituitary_gland1.59141351
21MP0002653_abnormal_ependyma_morphology1.56963626
22MP0005084_abnormal_gallbladder_morpholo1.56807477
23MP0001905_abnormal_dopamine_level1.56018480
24MP0008872_abnormal_physiological_respon1.55755126
25MP0002736_abnormal_nociception_after1.51668558
26MP0004142_abnormal_muscle_tone1.51224538
27MP0009697_abnormal_copulation1.50346077
28MP0002638_abnormal_pupillary_reflex1.49588430
29MP0005645_abnormal_hypothalamus_physiol1.46484228
30MP0002102_abnormal_ear_morphology1.46347094
31MP0001764_abnormal_homeostasis1.44995147
32MP0002095_abnormal_skin_pigmentation1.43951375
33MP0006035_abnormal_mitochondrial_morpho1.43385933
34MP0006072_abnormal_retinal_apoptosis1.41385389
35MP0001835_abnormal_antigen_presentation1.41205503
36MP0001853_heart_inflammation1.36407047
37MP0001984_abnormal_olfaction1.33119666
38MP0009745_abnormal_behavioral_response1.32807558
39MP0002272_abnormal_nervous_system1.30375440
40MP0001485_abnormal_pinna_reflex1.30334165
41MP0005367_renal/urinary_system_phenotyp1.29926704
42MP0000516_abnormal_urinary_system1.29926704
43MP0003786_premature_aging1.29693082
44MP0002138_abnormal_hepatobiliary_system1.27119492
45MP0008789_abnormal_olfactory_epithelium1.26919161
46MP0006292_abnormal_olfactory_placode1.22525149
47MP0005253_abnormal_eye_physiology1.21417531
48MP0005379_endocrine/exocrine_gland_phen1.20098995
49MP0005551_abnormal_eye_electrophysiolog1.19237964
50MP0009785_altered_susceptibility_to1.13788703
51MP0006276_abnormal_autonomic_nervous1.13087741
52MP0002148_abnormal_hypersensitivity_rea1.12596845
53MP0003136_yellow_coat_color1.10787646
54MP0005499_abnormal_olfactory_system1.04079961
55MP0005394_taste/olfaction_phenotype1.04079961
56MP0001486_abnormal_startle_reflex1.03855359
57MP0005636_abnormal_mineral_homeostasis1.03390066
58MP0003195_calcinosis1.03352528
59MP0003121_genomic_imprinting1.02859942
60MP0005174_abnormal_tail_pigmentation1.02408168
61MP0002163_abnormal_gland_morphology1.01052848
62MP0002928_abnormal_bile_duct1.00972109
63MP0002064_seizures0.99588330
64MP0005423_abnormal_somatic_nervous0.99061080
65MP0002822_catalepsy0.96358916
66MP0009764_decreased_sensitivity_to0.94571051
67MP0001501_abnormal_sleep_pattern0.93106877
68MP0005266_abnormal_metabolism0.91740957
69MP0005535_abnormal_body_temperature0.90787840
70MP0001929_abnormal_gametogenesis0.88870622
71MP0001800_abnormal_humoral_immune0.87532583
72MP0002572_abnormal_emotion/affect_behav0.86497966
73MP0002067_abnormal_sensory_capabilities0.86452050
74MP0002090_abnormal_vision0.84503282
75MP0000015_abnormal_ear_pigmentation0.84367047
76MP0002277_abnormal_respiratory_mucosa0.82251852
77MP0001970_abnormal_pain_threshold0.81274933
78MP0005332_abnormal_amino_acid0.80777204
79MP0005408_hypopigmentation0.80403329
80MP0003656_abnormal_erythrocyte_physiolo0.80335695
81MP0001727_abnormal_embryo_implantation0.79958581
82MP0002452_abnormal_antigen_presenting0.79411290
83MP0003698_abnormal_male_reproductive0.79243497
84MP0002938_white_spotting0.78743606
85MP0002723_abnormal_immune_serum0.77515693
86MP0002229_neurodegeneration0.77452923
87MP0004742_abnormal_vestibular_system0.75993196
88MP0002210_abnormal_sex_determination0.75952704
89MP0005000_abnormal_immune_tolerance0.75141589
90MP0002734_abnormal_mechanical_nocicepti0.75067555
91MP0001919_abnormal_reproductive_system0.74482576
92MP0004859_abnormal_synaptic_plasticity0.72622198
93MP0004885_abnormal_endolymph0.72601325
94MP0003011_delayed_dark_adaptation0.72154109
95MP0000631_abnormal_neuroendocrine_gland0.71985087
96MP0010386_abnormal_urinary_bladder0.71404098
97MP0009333_abnormal_splenocyte_physiolog0.71354282
98MP0002735_abnormal_chemical_nociception0.70766543
99MP0002557_abnormal_social/conspecific_i0.69421973
100MP0001819_abnormal_immune_cell0.69383825

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.21344985
2Mitochondrial inheritance (HP:0001427)4.97569566
3Abnormal mitochondria in muscle tissue (HP:0008316)4.73284142
4Hepatocellular necrosis (HP:0001404)4.62124804
5Progressive macrocephaly (HP:0004481)4.56496094
6Acute encephalopathy (HP:0006846)4.45211190
7Increased CSF lactate (HP:0002490)4.42093526
8Hepatic necrosis (HP:0002605)4.14087638
93-Methylglutaconic aciduria (HP:0003535)4.05306796
10Increased hepatocellular lipid droplets (HP:0006565)3.91840639
11Lipid accumulation in hepatocytes (HP:0006561)3.68373167
12Renal Fanconi syndrome (HP:0001994)3.52418275
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40325679
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40325679
15Increased intramyocellular lipid droplets (HP:0012240)3.21245216
16Cerebral edema (HP:0002181)3.14424917
17Lactic acidosis (HP:0003128)2.93590512
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92979284
19Increased serum lactate (HP:0002151)2.91756316
20Exertional dyspnea (HP:0002875)2.91307010
21Respiratory failure (HP:0002878)2.82300323
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75882492
23Increased muscle lipid content (HP:0009058)2.73729264
24Pancreatic cysts (HP:0001737)2.62804432
25Optic disc pallor (HP:0000543)2.58308351
26Abnormal number of erythroid precursors (HP:0012131)2.57689151
27Medial flaring of the eyebrow (HP:0010747)2.49173790
28Type I transferrin isoform profile (HP:0003642)2.47723591
29Exercise intolerance (HP:0003546)2.43615772
30Leukodystrophy (HP:0002415)2.42397877
31Myokymia (HP:0002411)2.41008554
32Emotional lability (HP:0000712)2.40868651
33Abnormality of cells of the erythroid lineage (HP:0012130)2.39046323
34Abnormality of midbrain morphology (HP:0002418)2.35500603
35Molar tooth sign on MRI (HP:0002419)2.35500603
36CNS demyelination (HP:0007305)2.35267815
37Pancreatic fibrosis (HP:0100732)2.28298183
38Congenital, generalized hypertrichosis (HP:0004540)2.28218246
39Methylmalonic acidemia (HP:0002912)2.27512550
40Lethargy (HP:0001254)2.26631068
41Gait imbalance (HP:0002141)2.24216372
42Methylmalonic aciduria (HP:0012120)2.23278479
43True hermaphroditism (HP:0010459)2.20003856
44Abnormal protein glycosylation (HP:0012346)2.19805630
45Abnormal glycosylation (HP:0012345)2.19805630
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19805630
47Abnormal protein N-linked glycosylation (HP:0012347)2.19805630
48Abnormality of the anterior horn cell (HP:0006802)2.18905194
49Degeneration of anterior horn cells (HP:0002398)2.18905194
50Microvesicular hepatic steatosis (HP:0001414)2.16498491
51Abnormality of renal resorption (HP:0011038)2.16315614
52Congenital primary aphakia (HP:0007707)2.14958830
53Focal motor seizures (HP:0011153)2.11926204
54Respiratory difficulties (HP:0002880)2.09932303
55Progressive microcephaly (HP:0000253)2.09645680
56Macrocytic anemia (HP:0001972)2.01076095
57Nephrogenic diabetes insipidus (HP:0009806)2.01009265
58Abnormality of urine glucose concentration (HP:0011016)1.93035025
59Glycosuria (HP:0003076)1.93035025
60Nephronophthisis (HP:0000090)1.92648641
61Atrophy/Degeneration involving motor neurons (HP:0007373)1.91420734
62Panhypogammaglobulinemia (HP:0003139)1.89151352
63Dicarboxylic aciduria (HP:0003215)1.88134319
64Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88134319
65Abnormal rod and cone electroretinograms (HP:0008323)1.81471839
66X-linked dominant inheritance (HP:0001423)1.79999005
67Hypothermia (HP:0002045)1.77903829
68Aplasia/hypoplasia of the uterus (HP:0008684)1.77804261
69Generalized aminoaciduria (HP:0002909)1.77325189
70Aplastic anemia (HP:0001915)1.74308243
71Delusions (HP:0000746)1.72889083
72Increased serum pyruvate (HP:0003542)1.68626581
73Severe combined immunodeficiency (HP:0004430)1.68224460
74Abnormality of the heme biosynthetic pathway (HP:0010472)1.67757654
75Gliosis (HP:0002171)1.66593024
76Neutropenia (HP:0001875)1.66384241
77Agammaglobulinemia (HP:0004432)1.65973123
78Cerebral hypomyelination (HP:0006808)1.65534130
79Severe visual impairment (HP:0001141)1.65199534
80Hyperglycinemia (HP:0002154)1.64861198
81Abnormality of the labia minora (HP:0012880)1.62918781
82Hyperphosphaturia (HP:0003109)1.62676657
83Reticulocytopenia (HP:0001896)1.61158623
84Amyotrophic lateral sclerosis (HP:0007354)1.60817231
85Abnormality of alanine metabolism (HP:0010916)1.60672010
86Hyperalaninemia (HP:0003348)1.60672010
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60672010
88Abolished electroretinogram (ERG) (HP:0000550)1.60646700
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60603980
90Congenital stationary night blindness (HP:0007642)1.59992024
91Abnormality of the renal medulla (HP:0100957)1.58596147
92Bile duct proliferation (HP:0001408)1.58040533
93Abnormal biliary tract physiology (HP:0012439)1.58040533
94Abnormality of the prostate (HP:0008775)1.57466138
95Abnormality of vitamin B metabolism (HP:0004340)1.56526217
96Constricted visual fields (HP:0001133)1.54822313
97Abnormality of B cell number (HP:0010975)1.54125193
98Delayed CNS myelination (HP:0002188)1.51869390
99B lymphocytopenia (HP:0010976)1.49659039
100Blindness (HP:0000618)1.49530682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.30605198
2TRIM283.10479499
3MST43.08376499
4MAP4K22.52576043
5NME22.36957055
6SIK32.26846133
7BCR2.26789859
8MAP3K122.22685250
9BMPR1B2.20843742
10BCKDK2.04364090
11BUB11.99021337
12TESK11.97273371
13SRPK11.90303119
14TXK1.84037206
15EIF2AK31.72011384
16STK161.68868828
17CDK81.65936512
18EIF2AK11.65900314
19ERBB31.65409018
20VRK11.56107775
21CSNK1G31.51060080
22LIMK11.47243406
23MAPK131.43379594
24CDK191.40969870
25BMPR21.39946482
26NUAK11.39411365
27PLK41.36836725
28CSNK1G21.35761242
29FRK1.35417537
30WNK31.26442946
31CCNB11.24358457
32PIM21.24344611
33DYRK21.18764737
34TAOK31.17809904
35TESK21.14612549
36CSNK1A1L1.13887624
37DAPK11.13731751
38MAP3K41.09767549
39CSNK1G11.07394246
40MINK11.06880746
41MAP2K71.05101344
42OXSR11.03892376
43TNIK1.00379067
44PLK20.99072146
45DAPK20.98875697
46IKBKB0.96925403
47ZAK0.91003028
48NEK10.83469146
49ADRBK20.81602834
50GRK10.79488523
51CAMKK20.78399952
52PINK10.76158019
53PASK0.75724685
54STK390.73192884
55NME10.73119870
56MAP4K10.73030206
57PLK30.70956931
58TEC0.68224385
59ABL20.67329539
60PBK0.63472773
61PHKG20.61633359
62PHKG10.61633359
63ILK0.61157517
64GRK70.61050701
65BRSK20.60260549
66RPS6KA40.60030111
67PRKCG0.58710044
68PIK3CA0.58418994
69TAOK20.57714371
70PKN10.57442415
71LYN0.56786778
72RIPK40.55239621
73TGFBR10.54424269
74CSNK1A10.53268128
75CSNK2A20.52488260
76IKBKE0.51726613
77SCYL20.51479311
78WEE10.51040178
79INSRR0.51025467
80CSNK2A10.49529764
81MATK0.49439589
82SYK0.48769521
83KDR0.47468793
84MKNK10.46028873
85RPS6KA50.45769937
86EIF2AK20.45739031
87MARK30.44521215
88KIT0.44389536
89EPHA40.43426289
90PRKCE0.42188776
91BRSK10.41487117
92PAK30.40781818
93DAPK30.40171466
94PRKCQ0.39716264
95DYRK30.39214718
96MARK10.39054376
97PDK20.38139969
98TBK10.38104172
99PLK10.37030503
100MKNK20.35658108

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.87029639
2Parkinsons disease_Homo sapiens_hsa050124.08550465
3Proteasome_Homo sapiens_hsa030504.08352526
4Protein export_Homo sapiens_hsa030604.05875504
5Ribosome_Homo sapiens_hsa030103.42668956
6Alzheimers disease_Homo sapiens_hsa050102.68902780
7Huntingtons disease_Homo sapiens_hsa050162.63795775
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48773117
9RNA polymerase_Homo sapiens_hsa030202.39896115
10Asthma_Homo sapiens_hsa053102.24508955
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15977042
12Homologous recombination_Homo sapiens_hsa034402.07479530
13Type I diabetes mellitus_Homo sapiens_hsa049401.86152227
14Collecting duct acid secretion_Homo sapiens_hsa049661.80697875
15Allograft rejection_Homo sapiens_hsa053301.80170281
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.74126079
17Cardiac muscle contraction_Homo sapiens_hsa042601.73050434
18Autoimmune thyroid disease_Homo sapiens_hsa053201.68645491
19Graft-versus-host disease_Homo sapiens_hsa053321.59447920
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55183986
21Mismatch repair_Homo sapiens_hsa034301.54171400
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41316022
23Rheumatoid arthritis_Homo sapiens_hsa053231.41134077
24RNA degradation_Homo sapiens_hsa030181.38052824
25Spliceosome_Homo sapiens_hsa030401.36777415
26Fatty acid elongation_Homo sapiens_hsa000621.36475891
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25103860
28Pyrimidine metabolism_Homo sapiens_hsa002401.24445645
29Phototransduction_Homo sapiens_hsa047441.19142972
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18026714
31Basal transcription factors_Homo sapiens_hsa030221.16979615
32Fanconi anemia pathway_Homo sapiens_hsa034601.15281746
33DNA replication_Homo sapiens_hsa030301.13789983
34Nucleotide excision repair_Homo sapiens_hsa034201.10336868
35Base excision repair_Homo sapiens_hsa034101.07752741
36Regulation of autophagy_Homo sapiens_hsa041401.06511776
37Antigen processing and presentation_Homo sapiens_hsa046121.05715090
38Primary immunodeficiency_Homo sapiens_hsa053401.03355054
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03268786
40Purine metabolism_Homo sapiens_hsa002300.96810072
41Butanoate metabolism_Homo sapiens_hsa006500.95485416
42Sulfur metabolism_Homo sapiens_hsa009200.93596959
43Peroxisome_Homo sapiens_hsa041460.92248974
44Propanoate metabolism_Homo sapiens_hsa006400.89857263
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86634364
46Nitrogen metabolism_Homo sapiens_hsa009100.85586421
47RNA transport_Homo sapiens_hsa030130.84268815
48Folate biosynthesis_Homo sapiens_hsa007900.83335171
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82533977
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.76867432
51Nicotine addiction_Homo sapiens_hsa050330.76267687
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71538519
53Glutathione metabolism_Homo sapiens_hsa004800.70540470
54Metabolic pathways_Homo sapiens_hsa011000.70140867
55Synaptic vesicle cycle_Homo sapiens_hsa047210.70096746
56Non-homologous end-joining_Homo sapiens_hsa034500.69189421
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66347177
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65328881
59One carbon pool by folate_Homo sapiens_hsa006700.61047926
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56847908
61Vibrio cholerae infection_Homo sapiens_hsa051100.55841271
62Sulfur relay system_Homo sapiens_hsa041220.54419894
63Epstein-Barr virus infection_Homo sapiens_hsa051690.54087730
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47924828
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.45048151
66Ether lipid metabolism_Homo sapiens_hsa005650.44692281
67GABAergic synapse_Homo sapiens_hsa047270.44304756
68Olfactory transduction_Homo sapiens_hsa047400.44263916
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.42582784
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42387214
71Legionellosis_Homo sapiens_hsa051340.41543211
72Hematopoietic cell lineage_Homo sapiens_hsa046400.37904892
73Viral myocarditis_Homo sapiens_hsa054160.37452978
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37312010
75Linoleic acid metabolism_Homo sapiens_hsa005910.36976473
76Herpes simplex infection_Homo sapiens_hsa051680.36704209
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35033707
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34979895
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.33263258
80Tryptophan metabolism_Homo sapiens_hsa003800.33258075
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32679536
82Chemical carcinogenesis_Homo sapiens_hsa052040.32208472
83Pyruvate metabolism_Homo sapiens_hsa006200.29715394
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27390356
85Arachidonic acid metabolism_Homo sapiens_hsa005900.27204262
86Oocyte meiosis_Homo sapiens_hsa041140.24878345
87Selenocompound metabolism_Homo sapiens_hsa004500.24482550
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24321862
89Morphine addiction_Homo sapiens_hsa050320.23835376
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22535566
91Taste transduction_Homo sapiens_hsa047420.21956452
92Carbon metabolism_Homo sapiens_hsa012000.21289440
93Mineral absorption_Homo sapiens_hsa049780.20461273
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19689362
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19673421
96Fatty acid metabolism_Homo sapiens_hsa012120.19551955
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19219891
98Phagosome_Homo sapiens_hsa041450.18915304
99Steroid biosynthesis_Homo sapiens_hsa001000.16723719
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16254293

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